Receptor
PDB id Resolution Class Description Source Keywords
3MWU 1.98 Å EC: 2.7.11.17 ACTIVATED CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM CRYPTOSPOR PARVUM (CPCDPK1) IN COMPLEX WITH BUMPED KINASE INHIBITOR RM CRYPTOSPORIDIUM PARVUM SERINE/THREONINE PROTEIN KINASE TRANSFERASE CALCIUM-BINDINBINDING CALMODULIN BUMPED KINASE INHIBITOR BKI STRUCTURGENOMICS MEDICAL STRUCTURAL GENOMICS OF PATHOGENIC PROTOZOTRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: DISCOVERY OF POTENT AND SELECTIVE INHIBITORS OF CALCIUM-DEPENDENT PROTEIN KINASE 1 (CDPK1) FROM C. AND T. GONDII. ACS MED CHEM LETT V. 1 331 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BK3 A:561;
Valid;
none;
submit data
372.466 C22 H24 N6 c1ccc...
CA A:551;
A:552;
A:553;
A:554;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3IGO 2.25 Å EC: 2.7.11.17 CRYSTAL STRUCTURE OF CRYPTOSPORIDIUM PARVUM CDPK1, CGD3_920 CRYPTOSPORIDIUM PARVUM PARASITE KINASE CDPK STRUCTURAL GENOMICS STRUCTURAL GENOCONSORTIUM SGC ATP-BINDING NUCLEOTIDE-BINDING SERINE/THPROTEIN KINASE TRANSFERASE
Ref.: STRUCTURES OF APICOMPLEXAN CALCIUM-DEPENDENT PROTEI REVEAL MECHANISM OF ACTIVATION BY CALCIUM. NAT.STRUCT.MOL.BIOL. V. 17 596 2010
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 3IGO - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 3NCG - BK1 C19 H19 N5 CC(C)n1c2c....
3 3MWU - BK3 C22 H24 N6 c1ccc2c(c1....
70% Homology Family (21)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 3IGO - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 3NCG - BK1 C19 H19 N5 CC(C)n1c2c....
3 3MWU - BK3 C22 H24 N6 c1ccc2c(c1....
4 4ONA ic50 = 0.002 uM UW1 C19 H23 N5 O2 CCOc1ccc2c....
5 4JBV ic50 = 0.003 uM V68 C26 H32 N6 O CC(C)COc1c....
6 3NYV - DTQ C16 H15 N3 O3 COc1cc2c(c....
7 3T3U Ki = 0.0025 uM BK6 C22 H24 N6 O COc1ccc2cc....
8 3KU2 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
9 4M84 ic50 = 0.049 uM 21E C17 H19 N5 O CC(C)(C)n1....
10 3HX4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
11 3UPX Ki = 0.0075 uM B6A C20 H22 N4 O c1ccc(cc1)....
12 3SXF Ki = 0.0025 uM BK5 C20 H21 N5 O CCOc1ccc2c....
13 3T3V Ki = 0.003 uM BK4 C19 H19 N5 O CC(C)n1c2c....
14 3I7B ic50 = 0.066 uM BK1 C19 H19 N5 CC(C)n1c2c....
15 3V5P Ki = 0.011 uM C88 C19 H24 N6 O Cc1cc(ccc1....
16 3V51 - I76 C25 H22 Cl N5 O CC(C)n1c2c....
17 3UPZ - B5A C11 H16 N6 c1c2c(ncnc....
18 3I7C ic50 = 0.018 uM BK2 C19 H19 N5 CC(C)(C)n1....
19 3V5T - UW9 C24 H30 N6 O CCOc1ccc2c....
20 3N51 - BK3 C22 H24 N6 c1ccc2c(c1....
21 3HZT - J60 C22 H27 Cl N4 O2 CCN(CC)CCN....
50% Homology Family (21)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3IGO - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 3NCG - BK1 C19 H19 N5 CC(C)n1c2c....
3 3MWU - BK3 C22 H24 N6 c1ccc2c(c1....
4 4ONA ic50 = 0.002 uM UW1 C19 H23 N5 O2 CCOc1ccc2c....
5 4JBV ic50 = 0.003 uM V68 C26 H32 N6 O CC(C)COc1c....
6 3NYV - DTQ C16 H15 N3 O3 COc1cc2c(c....
7 3T3U Ki = 0.0025 uM BK6 C22 H24 N6 O COc1ccc2cc....
8 3KU2 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
9 4M84 ic50 = 0.049 uM 21E C17 H19 N5 O CC(C)(C)n1....
10 3HX4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
11 3UPX Ki = 0.0075 uM B6A C20 H22 N4 O c1ccc(cc1)....
12 3SXF Ki = 0.0025 uM BK5 C20 H21 N5 O CCOc1ccc2c....
13 3T3V Ki = 0.003 uM BK4 C19 H19 N5 O CC(C)n1c2c....
14 3I7B ic50 = 0.066 uM BK1 C19 H19 N5 CC(C)n1c2c....
15 3V5P Ki = 0.011 uM C88 C19 H24 N6 O Cc1cc(ccc1....
16 3V51 - I76 C25 H22 Cl N5 O CC(C)n1c2c....
17 3UPZ - B5A C11 H16 N6 c1c2c(ncnc....
18 3I7C ic50 = 0.018 uM BK2 C19 H19 N5 CC(C)(C)n1....
19 3V5T - UW9 C24 H30 N6 O CCOc1ccc2c....
20 3N51 - BK3 C22 H24 N6 c1ccc2c(c1....
21 3HZT - J60 C22 H27 Cl N4 O2 CCN(CC)CCN....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: BK3; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 BK3 1 1
2 BK1 0.545455 0.75
3 BK6 0.424528 0.844828
4 C88 0.407767 0.803279
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3IGO; Ligand: ANP; Similar sites found: 340
This union binding pocket(no: 1) in the query (biounit: 3igo.bio1) has 23 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1IOW PHY 0.002648 0.43163 1.30719
2 1IOW ADP 0.002648 0.43163 1.30719
3 2VPQ ANP 0.0001597 0.46797 1.33038
4 5C1P DAL DAL 0.006112 0.40479 1.63399
5 5C1P ADP 0.001152 0.40389 1.63399
6 2VQD AP2 0.0005501 0.43989 1.72414
7 1EHI ADP 0.002376 0.40966 1.85676
8 2HGS ADP 0.002154 0.42058 1.89873
9 2PUL ACP 0.000004229 0.50189 2.01511
10 3OV6 MK0 0.007979 0.40686 2.01511
11 3D91 REM 0.01906 0.41389 2.05279
12 3KAL ADP 0.01066 0.40382 2.05761
13 5X1M THG 0.01137 0.40139 2.1097
14 2IF8 ADP 0.0001976 0.40555 2.20386
15 2IO8 ADP 0.0006109 0.44542 2.26337
16 3DNT ATP 0.006828 0.40117 2.27273
17 3TM0 B31 0.001389 0.44263 2.28137
18 3TM0 ANP 0.001293 0.44263 2.28137
19 4CYI ATP 0.0001479 0.46167 2.28311
20 3WO0 ALA 0.005591 0.42078 2.34043
21 4NZN 2OU 0.004184 0.43164 2.42424
22 4NZN ANP 0.004184 0.43164 2.42424
23 4C5N ACP 0.009279 0.40647 2.53623
24 2V58 LZJ 0.0005639 0.47206 2.67261
25 3UDZ ADP 0.0000004248 0.55858 2.6749
26 3W0O ADP 0.003273 0.42232 2.86533
27 3W0O HY0 0.003273 0.42232 2.86533
28 5DQ8 FLF 0.006761 0.40135 2.91667
29 4ZS4 ATP 0.00001606 0.49751 2.9316
30 5GZ9 ANP 0.00000002708 0.62605 2.95082
31 4ITU NAI 0.01133 0.40381 2.97398
32 1PK8 ATP 0.00003728 0.49872 3.08057
33 3PDT ADP 0.000004204 0.49822 3.27273
34 1M0W ANP 0.0009778 0.41249 3.29218
35 3SHR CMP 0.0006835 0.40041 3.34448
36 4OYA 1VE 0.02555 0.40909 3.40426
37 3ORQ ADP 0.002062 0.41653 3.44828
38 2BKK ADP 0.0002945 0.42351 3.5503
39 5MW8 ATP 0.0000001295 0.59756 3.60934
40 1I7L ATP 0.00008713 0.48109 3.8835
41 5ML3 DL3 0.0127 0.40489 4.02685
42 1GSA ADP 0.00008177 0.48016 4.11392
43 3V4S ADP 0.006942 0.41437 4.13437
44 3V4S ATP 0.004202 0.40663 4.13437
45 3VOT ADP 0.0004052 0.41861 4.23529
46 5EQY 5RA 0.003344 0.43893 4.48878
47 5IQD RIO 0.0002115 0.48401 4.59016
48 5IQD GNP 0.0001972 0.48401 4.59016
49 4U98 ACP 0.0003609 0.43438 4.73251
50 5A5W GUO 0.005722 0.4235 4.74308
51 4AXD ANP 0.0000003023 0.61036 4.82456
52 4ANW O92 0.001005 0.44741 4.93827
53 5W2I ADP 0.001301 0.43158 5.05837
54 5W2I I3P 0.001301 0.43158 5.05837
55 3TDV GDP 0.0000009494 0.53764 5.22876
56 2PYW ADP 0.000002655 0.53346 5.2381
57 3I0O ADP 0.00001772 0.46218 5.30973
58 1IA9 ANP 0.00002885 0.48649 5.35714
59 3WVR AMP 0.0002411 0.43204 5.36913
60 5C4L SIS 0.00002529 0.51539 5.60748
61 5C4L 4XR 0.0001042 0.4887 5.60748
62 4X6F 3XU 0.01619 0.40217 5.71429
63 4OCJ NDG 0.0001883 0.48624 5.80475
64 4OCV ANP 0.0001579 0.46125 6.0686
65 4N9I PCG 0.02573 0.40073 6.19048
66 1ZTH ADP 0.0000004198 0.51267 6.20155
67 1ZP9 ATP 0.000001891 0.50888 6.20155
68 2GQS ADP 0.001882 0.40582 6.32911
69 2GC0 PAN 0.002391 0.40369 6.91489
70 4GYI ADP 0.0001453 0.43678 7.0529
71 3AKK ADP 0.0004584 0.43942 7.07692
72 5VZ0 ADP 0.000303 0.4352 7.40741
73 5K2M ADP 0.0002319 0.46316 7.54717
74 2AQX ATP 0.002735 0.41442 7.95848
75 1W6P NDG GAL 0.0123 0.41962 8.20895
76 3K5I ADP 0.001613 0.42114 8.43672
77 3K5I AIR 0.005897 0.41387 8.43672
78 5CKW ANP 0.00003249 0.45443 8.64745
79 5NCY 8TK 0.008433 0.40452 8.84774
80 4OUC 5ID 0.000006138 0.49121 8.96359
81 1AUX AGS 0.00003487 0.47649 9.00322
82 3RE4 TO1 0.000006342 0.47316 9.30233
83 2YW2 ATP 0.001636 0.42019 9.46502
84 5I35 ANP 0.000002013 0.51772 9.66921
85 3ETH ATP 0.001743 0.42258 10.4225
86 1TQP ATP 0.00001818 0.50978 10.6383
87 4O1P ANP 0.0000005085 0.54735 10.6996
88 5U98 1KX 0.03494 0.40009 10.8303
89 3VPB ADP 0.00008054 0.48454 11.3475
90 3VPC ADP 0.0003424 0.45206 11.3475
91 3VPD ANP 0.001806 0.42194 11.7438
92 4XYM A12 0.002288 0.41065 13.4783
93 4LRJ ANP 0.0000002898 0.54868 13.6095
94 4XH0 ADP 0.0000001262 0.4913 13.6476
95 3Q60 ATP 0.000001663 0.51834 14.8248
96 4IX4 ADP 0.0000261 0.49321 14.8571
97 4AZW ATP 0.001696 0.4197 15.0743
98 4OAV ACP 0.00000221 0.51562 15.4321
99 4O4F ATP 0.001834 0.42699 15.7258
100 4O4F IHP 0.002004 0.42699 15.7258
101 1W2D ADP 0.0006181 0.40825 16.6038
102 1W2D 4IP 0.007112 0.40637 16.6038
103 4Q5H ANP 0.00002667 0.48372 18.4211
104 3OCP CMP 0.0006269 0.40329 18.705
105 3VHE 42Q 0.00000009167 0.61907 21.4485
106 3PVW QRX 0.000000009475 0.65387 21.8107
107 4FL3 ANP 0.00000004198 0.61508 21.8107
108 5UKL SIX 0.000001039 0.56923 21.8107
109 4Y93 746 0.000006807 0.53002 22.1973
110 4L9I 8PR 0.000002098 0.51959 22.2222
111 2PZI AXX 0.0001557 0.4344 22.2222
112 1OPK P16 0.000003142 0.55469 24.4856
113 2H8H H8H 0.000002207 0.52216 24.8971
114 4NFN 2KC 0.000001183 0.52353 24.9191
115 5DMZ ADP 0.000000001204 0.6486 25.2055
116 3VRY B43 0.0000002419 0.59145 25.7709
117 3GNI ATP 0.0000007545 0.55461 26.7352
118 1Y57 MPZ 0.0000623 0.48511 26.7699
119 5W4W 9WG 0.00000001194 0.65972 26.8882
120 4KBA 1QM 0.0000001339 0.60731 26.8882
121 4WNK 453 0.0000002873 0.59763 26.9547
122 4WOV 3SM 0.0002027 0.43096 27.1293
123 2RIO ADP 0.00000001417 0.59713 27.1889
124 5T8O 76Z 0.000001762 0.54032 27.2206
125 4G17 0VN 0.000006779 0.4836 27.8788
126 5LPZ ADP 0.000005703 0.50662 28.012
127 4WW7 AMP 0.00009116 0.47601 28.3525
128 4E93 GUI 0.000005998 0.54434 28.382
129 3UIM ANP 0.000006953 0.504 28.5276
130 4F9C 0SX 0.00000008374 0.56781 28.5319
131 4Y0X ADP 0.000001155 0.52101 28.8
132 2JLD AG1 0.0000001203 0.6204 29.0476
133 3TTI KBI 0.000000002845 0.67892 29.7414
134 4JR7 GNP 0.0000001338 0.56795 29.9465
135 4DC2 ADE 0.0000001834 0.46829 30.0505
136 4IJP 1EH 0.00000263 0.53351 30.1676
137 4P5Z Q7M 0.000001358 0.58138 30.4709
138 5C03 AGS 0.00003975 0.47546 30.7018
139 3E8N ATP 0.0000001302 0.63673 30.7918
140 3E8N VRA 0.003071 0.46793 30.7918
141 3C1X CKK 0.0002074 0.46113 30.8311
142 4OH4 ANP 0.00001216 0.49437 30.9309
143 5EOB 5QQ 0.00000002207 0.68388 31.0345
144 2R5T ANP 0.0000000007558 0.68779 31.0992
145 3LXK MI1 0.0000001179 0.60968 31.1927
146 5LI1 ANP 0.000000001528 0.67506 31.3559
147 5LPB ADP 0.000004622 0.4809 31.4189
148 4U0I 0LI 0.000003819 0.55102 31.4286
149 3KRL KRL 0.00003755 0.49206 31.6418
150 3PP0 03Q 0.0000001979 0.59765 31.6568
151 5LI9 ACP 0.0000000002761 0.6825 31.7143
152 2CSN CKI 0.000000002731 0.67689 31.9865
153 5HCY 60D 0.00000008095 0.64446 32.0242
154 4BKJ STI 0.00003853 0.49811 32.0635
155 4YZC STU 0.000000001745 0.70765 32.0988
156 3V8S 0HD 0.00000002547 0.58499 32.1951
157 4WB7 ATP 0.00000075 0.58933 32.3457
158 4NM5 ADP 0.001359 0.45961 32.3607
159 5USZ SKE 0.000008331 0.53052 32.526
160 4E1Z 0MX 0.000001671 0.55099 32.646
161 3KMW ATP 0.0009395 0.41869 32.8413
162 4IDT T28 0.000001526 0.52061 32.8652
163 3ZRM ZRM 0.000001837 0.52658 32.8841
164 4BTK DTQ 0.000008275 0.5017 32.9377
165 1VJY 460 0.000000003018 0.68808 33.0033
166 5HVJ ANP 0.0000001638 0.47213 33.0159
167 2F2U M77 0.00000005262 0.54101 33.0846
168 5HES 032 0.0000003783 0.57529 33.2248
169 5M06 ADP 0.000001898 0.50624 33.6957
170 4CLI 5P8 0.00003084 0.52795 33.945
171 4ITH RCM 0.002289 0.41765 34.0136
172 5UIU 8CG 0.0000007124 0.58059 34.0557
173 4GJ3 0XP 0.00000009024 0.6216 34.106
174 3F7Z 34O 0.0000009252 0.53817 34.8571
175 4CRL C1I 0.000002678 0.56144 34.9754
176 4YMJ 4EJ 0.000004291 0.45249 35.1974
177 5NKB 8ZT 0.0000005702 0.60308 35.2941
178 5MY8 RXZ 0.0000009997 0.56533 35.5091
179 3LXN MI1 0.000000004534 0.64509 35.5346
180 4ASE AV9 0.0000002754 0.59391 35.694
181 5MJA 7O3 0.0000001272 0.5488 35.7377
182 2XVD AS6 0.000001118 0.57003 35.7616
183 4WHZ 3NL 0.000001276 0.59601 35.8442
184 1U5R ATP 0.00000006361 0.56985 35.9195
185 1Q8Y ADP 0.000000003162 0.65202 35.9249
186 1Q8Y ADE 0.00000002172 0.5398 35.9249
187 4UAL 3FV 0.00000001691 0.60261 36.0382
188 2PVF ACP 0.0000001552 0.55757 36.2275
189 5AWM ANP 0.000001699 0.49158 36.2944
190 2X2M X2M 0.000000008275 0.64448 36.3057
191 3ORK AGS 0.0000002186 0.59331 36.3344
192 4Y85 499 0.001096 0.41408 36.4458
193 5U6C 7YS 0.00007183 0.48032 36.5079
194 5FBN 5WF 0.000002262 0.56645 36.5314
195 3SXS PP2 0.00000008355 0.59331 36.5672
196 4I94 ANP 0.00002104 0.477 36.6667
197 5TA6 79D 0.000001964 0.55739 36.8715
198 3MVH WFE 0.0000004289 0.59011 37.1345
199 3KRR DQX 0.0000001742 0.65207 37.2881
200 4WB6 ATP 0.00000001292 0.64813 37.4286
201 4G31 0WH 0.0000006125 0.58948 37.4582
202 2QCS ANP 0.00000001376 0.64697 37.7143
203 5EKO N17 0.000325 0.45503 37.7358
204 5LXC 7AA 0.0000000005924 0.63321 37.7451
205 5KO1 6UY 0.00002905 0.47095 37.8092
206 4K33 ACP 0.0000001859 0.57172 37.8462
207 5JKG 6LF 0.0000001547 0.62328 37.9421
208 5VCV 1N1 0.0000002267 0.59006 37.9421
209 3FHI ANP 0.00000002402 0.63666 38
210 1RE8 BD2 0.0000005438 0.61008 38
211 3IDB ANP 0.000001954 0.54815 38
212 3PTG 932 0.000003353 0.47731 38.0165
213 4N70 2HX 0.0000008322 0.60448 38.1098
214 3GQI ACP 0.0000007327 0.54053 38.3436
215 3GC8 B45 0.0000004502 0.57214 38.3784
216 1XJD STU 0.0000001058 0.58223 38.5507
217 2OFV 242 0.000004667 0.55432 38.6282
218 4XV1 904 0.00000001807 0.65643 38.6986
219 2B9I ADP 0.0000002128 0.56253 38.8102
220 2B9F ADP 0.0000002177 0.56143 38.8102
221 2B9J ADP 0.0000001454 0.56012 38.8102
222 2B9H ADP 0.0000003869 0.56001 38.8102
223 3TXO 07U 0.00000009217 0.55747 38.8102
224 3ALN ANP 0.000001577 0.54165 38.8379
225 3HMO STU 0.0000002274 0.55019 38.8889
226 1CM8 ANP 0.00002302 0.47299 38.9646
227 5CEO 50D 0.00004736 0.47096 39
228 4OTH DRN 0.00000002543 0.62415 39.0029
229 2WU6 DKI 0.0000003244 0.58084 39.1076
230 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.00000007949 0.66077 39.1813
231 2JDR L20 0.00000007949 0.66077 39.1813
232 4JDI ANP 0.000000005239 0.6432 39.3064
233 1OUK 084 0.0000001555 0.68264 39.3443
234 3SRV S19 0.000000116 0.56116 39.3502
235 3FC2 IBI 0.002299 0.4601 39.403
236 2GU8 796 0.00000003986 0.67336 39.4659
237 3PLS ANP 0.00000003599 0.58182 39.5973
238 5JFS 6K0 0.000000578 0.60121 39.6104
239 3CY2 MB9 0.0000008315 0.5637 39.8089
240 4IZY 1J2 0.00000007262 0.59687 39.8374
241 4AG8 AXI 0.0000002534 0.61011 39.8734
242 4LOO SB4 0.0000001818 0.56505 39.8892
243 4F4P 0SB 0.00000405 0.58359 39.9267
244 1BYG STU 0.00000003326 0.56978 39.9281
245 3RI1 3RH 0.000001127 0.56545 39.9361
246 5JGA 6KC 0.00000002768 0.64613 40
247 3E7O 35F 0.0000006035 0.5878 40
248 2OO8 RAJ 0.0001573 0.46613 40.0631
249 3NW7 LGV 0.000001281 0.59318 40.0651
250 5UR1 YY9 0.00000004134 0.65594 40.1929
251 2Y6O 1N1 0.000001252 0.55362 40.2062
252 5BYZ 4WE 0.0000002533 0.60215 40.2299
253 4M69 ANP 0.0000001008 0.59101 40.2827
254 2PVN P63 0.0000001535 0.60713 40.3409
255 1U59 STU 0.0000004243 0.55141 40.4181
256 5X8I SQZ 0.000000006999 0.61754 40.4624
257 1K3A ACP 0.000004281 0.49255 40.4682
258 3DLS ADP 0.000006049 0.49249 40.597
259 4RFM 3P6 0.000226 0.49333 40.6015
260 2WQN ADP 0.000000008159 0.58029 40.6452
261 4CQE CQE 0.0000005635 0.56807 40.6475
262 4UX9 ANP 0.000000004013 0.64776 40.6593
263 4U44 3D9 0.000002247 0.52168 40.6627
264 4QTB 38Z 0.00000004097 0.6318 40.7895
265 5LVP ATP 0.000000002735 0.59925 40.836
266 3BU5 ATP 0.0000002938 0.55471 40.8497
267 3H9R TAK 0.00001874 0.44636 40.9091
268 5VC5 96M 0.0000005045 0.58266 41.1765
269 4Y8D 49J 0.0000001261 0.56892 41.1765
270 4YLL 4E3 0.00000000412 0.66033 41.2742
271 3GC0 AMP 0.00003739 0.4632 41.3374
272 3QCQ 3Q0 0.0000003086 0.65773 41.3462
273 3EKK GS2 0.0000001096 0.62808 41.3681
274 4H3Q ANP 0.00000001417 0.63785 41.4365
275 3PE2 E1B 0.000002372 0.58103 41.543
276 4X7Q 3YR 0.000001113 0.53356 41.6667
277 4H3P ANP 0.0000000719 0.5792 41.7127
278 5HX8 66P 0.000001367 0.56189 41.7219
279 2YAB AMP 0.00000002094 0.61113 41.8283
280 4XLI 1N1 0.0000001462 0.55638 42.1642
281 4EWH T77 0.00000007786 0.6174 42.1818
282 5DRB 5FJ 0.0000006405 0.60685 42.268
283 3G5D 1N1 0.0000008364 0.61206 42.3077
284 5BVE 4VG 0.000000003265 0.73079 42.3823
285 4NST ADP 0.0000006416 0.54354 42.735
286 5N87 N66 0.0000001797 0.6167 42.8115
287 3OFM 4B0 0.0000002165 0.53424 42.8571
288 5DBX ANP 0.000000005492 0.58309 42.9878
289 4I6H 1C8 0.0000131 0.49169 43.1818
290 5TO8 7FM 0.000003569 0.56432 43.2624
291 2HK5 1BM 0.000001215 0.54683 43.3333
292 5EFQ ADP 0.0000006403 0.54377 43.5159
293 4TWP AXI 0.0000004713 0.61143 43.5424
294 4EUU BX7 0.000001594 0.55905 43.8871
295 3SLS ANP 0.000000632 0.566 44.0789
296 5DH3 5BS 0.000006917 0.51558 44.127
297 4AT3 LTI 0.00005723 0.49829 44.1472
298 4YZN 4K5 0.0000000342 0.6218 44.2509
299 4NW6 2NS 0.00000001222 0.66161 44.2724
300 5IH9 6BF 0.000001934 0.57119 44.4776
301 2Z7R STU 0.000000000763 0.68762 44.5483
302 5H2U 1N1 0.000002574 0.51848 44.5693
303 4D2S DYK 0.000002347 0.49003 44.7183
304 5AX9 4KT 0.00001777 0.48012 44.8052
305 5DA3 58V 0.00000283 0.48006 44.9057
306 5DEY 59T 0.00000007118 0.65898 45.1178
307 4QMN DB8 0.00000004127 0.64487 45.1613
308 3DAK ANP 0.0000002659 0.53683 45.1724
309 4BFM ANP 0.000000000407 0.68841 45.2096
310 4BHN BH9 0.000001741 0.54087 45.2096
311 2J7T 274 0.00001018 0.53068 45.3642
312 4USF 6UI 0.0001304 0.47371 45.7237
313 3TKI S25 0.000004156 0.57747 45.8204
314 2X4Z X4Z 0.00000001864 0.658 45.9459
315 2HY0 306 0.000004223 0.48539 45.9627
316 4WNP 3RJ 0.0000006738 0.51526 45.993
317 5HQ0 LZ9 0.0000001316 0.58623 46.0265
318 2F57 23D 0.000002814 0.50237 46.0568
319 5UOX 8GY 0.000003919 0.53297 46.1255
320 4KS7 X4Z 0.00000005 0.61489 46.2329
321 3GGF GVD 0.000004588 0.49414 46.5116
322 1ZY5 ANP 0.0001329 0.44886 46.5347
323 4AUA 4AU 0.0000165 0.48404 46.9055
324 4CSV STI 0.00001146 0.51593 46.9091
325 2BPM 529 0.000000147 0.63886 47.5728
326 3BZ3 YAM 0.000008465 0.56545 48.1884
327 2A19 ANP 0.0000006553 0.51074 48.2394
328 4AU8 Z3R 0.00001269 0.46515 48.3108
329 2XK9 XK9 0.0000001278 0.62321 48.4472
330 4CFU 2WC 0.0000008193 0.51974 48.5149
331 1UNH IXM 0.0000005175 0.51569 48.6301
332 3O0G 3O0 0.000005793 0.49716 48.6301
333 3M2W L8I 0.00000003318 0.56061 48.8294
334 4BCQ TJF 0.00003071 0.45135 48.8372
335 4BCM T7Z 0.00001599 0.44544 48.8372
336 4BCN T9N 0.000008434 0.47746 49
337 2XMY CDK 0.00000007751 0.66979 49.3289
338 4L3L 5FI 0.0000002939 0.59721 49.3421
339 5LMK 6ZK 0.00008624 0.44834 49.4949
340 3C0G 3AM 0.0000001837 0.5347 49.8576
341 3FHR P4O 0.000007308 0.50774 50
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