Receptor
PDB id Resolution Class Description Source Keywords
3M6W 1.3 Å EC: 2.1.1.- MULTI-SITE-SPECIFIC 16S RRNA METHYLTRANSFERASE RSMF FROM THE THERMOPHILUS IN SPACE GROUP P21212 IN COMPLEX WITH S-ADENOSM ETHIONINE THERMUS THERMOPHILUS RRNA METHYLTRANSFERASE 5-METHYLCYTIDINE RSMF ADOMET MULTSPECIFIC METHYLTRANSFERASE TRANSFERASE
Ref.: MULTI-SITE-SPECIFIC 16S RRNA METHYLTRANSFERASE RSMF THERMUS THERMOPHILUS. RNA V. 16 1584 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:466;
Invalid;
none;
submit data
35.453 Cl [Cl-]
SAM A:465;
Valid;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3M6W 1.3 Å EC: 2.1.1.- MULTI-SITE-SPECIFIC 16S RRNA METHYLTRANSFERASE RSMF FROM THE THERMOPHILUS IN SPACE GROUP P21212 IN COMPLEX WITH S-ADENOSM ETHIONINE THERMUS THERMOPHILUS RRNA METHYLTRANSFERASE 5-METHYLCYTIDINE RSMF ADOMET MULTSPECIFIC METHYLTRANSFERASE TRANSFERASE
Ref.: MULTI-SITE-SPECIFIC 16S RRNA METHYLTRANSFERASE RSMF THERMUS THERMOPHILUS. RNA V. 16 1584 2010
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 57 families.
1 3M6V - SAM C15 H22 N6 O5 S C[S@@+](CC....
2 3M6W - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 50 families.
1 3M6V - SAM C15 H22 N6 O5 S C[S@@+](CC....
2 3M6W - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 44 families.
1 3M6V - SAM C15 H22 N6 O5 S C[S@@+](CC....
2 3M6W - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 192
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 XYA 0.565789 0.773333
9 ADN 0.565789 0.773333
10 RAB 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 AMP MG 0.511364 0.710843
25 5AL 0.510417 0.743902
26 VMS 0.510204 0.673913
27 54H 0.510204 0.673913
28 0UM 0.51 0.857143
29 A 0.505747 0.707317
30 AMP 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 DAL AMP 0.50505 0.765432
34 NVA LMS 0.504951 0.725275
35 K15 0.5 0.883117
36 6RE 0.5 0.78481
37 5AD 0.5 0.75
38 SSA 0.5 0.684783
39 SON 0.5 0.746988
40 SRP 0.5 0.746988
41 LSS 0.49505 0.706522
42 CA0 0.494624 0.714286
43 A12 0.494505 0.705882
44 AP2 0.494505 0.705882
45 ME8 0.490385 0.841463
46 5CA 0.49 0.684783
47 TSB 0.49 0.681319
48 53H 0.49 0.666667
49 ACP 0.489362 0.694118
50 5AS 0.48913 0.648936
51 ADP 0.48913 0.690476
52 A2D 0.488889 0.690476
53 J7C 0.488889 0.772152
54 ZAS 0.488636 0.769231
55 8QN 0.485149 0.743902
56 GAP 0.484536 0.73494
57 AN2 0.483871 0.682353
58 A3S 0.483871 0.813333
59 A7D 0.483871 0.851351
60 GJV 0.483516 0.775
61 SRA 0.483146 0.694118
62 LAD 0.480769 0.752941
63 KAA 0.480769 0.698925
64 GSU 0.480769 0.722222
65 AMO 0.480392 0.746988
66 DSZ 0.480392 0.703297
67 52H 0.48 0.666667
68 ADP MG 0.478723 0.702381
69 M33 0.478723 0.722892
70 MAO 0.478261 0.82716
71 BA3 0.478261 0.690476
72 AOC 0.477778 0.776316
73 DSH 0.477778 0.842105
74 NEC 0.477778 0.75
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 Y3J 0.47561 0.706667
78 G5A 0.474227 0.684783
79 A3T 0.473684 0.8
80 ADP BEF 0.473684 0.686047
81 BEF ADP 0.473684 0.686047
82 B4P 0.473118 0.690476
83 AP5 0.473118 0.690476
84 A3N 0.472527 0.766234
85 KB1 0.471698 0.833333
86 LEU LMS 0.471154 0.706522
87 APC 0.46875 0.705882
88 PRX 0.46875 0.73494
89 PAJ 0.466019 0.712644
90 4AD 0.466019 0.759036
91 RBY 0.463918 0.72619
92 ADP PO3 0.463918 0.728395
93 ADV 0.463918 0.72619
94 ADX 0.463158 0.666667
95 MHZ 0.463158 0.82716
96 AU1 0.463158 0.674419
97 YAP 0.462963 0.738095
98 TXA 0.462264 0.72619
99 NB8 0.462264 0.72093
100 A3G 0.461538 0.802632
101 VRT 0.459184 0.842105
102 ATP MG 0.459184 0.702381
103 YSA 0.458716 0.684783
104 XAH 0.458716 0.715909
105 50T 0.458333 0.682353
106 ATP 0.458333 0.690476
107 7D7 0.45679 0.723684
108 ANP MG 0.455446 0.678161
109 KH3 0.455357 0.871795
110 ACQ 0.454545 0.694118
111 AQP 0.453608 0.690476
112 5FA 0.453608 0.690476
113 AR6 0.453608 0.710843
114 APR 0.453608 0.710843
115 NSS 0.451923 0.703297
116 FA5 0.449541 0.746988
117 AGS 0.44898 0.678161
118 SAP 0.44898 0.678161
119 A5D 0.44898 0.789474
120 AD9 0.44898 0.674419
121 PTJ 0.448598 0.72093
122 YLB 0.448276 0.758621
123 YLP 0.447368 0.738636
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 TYR AMP 0.445455 0.746988
128 MYR AMP 0.444444 0.776471
129 3AM 0.444444 0.674699
130 OAD 0.443396 0.73494
131 2VA 0.443299 0.779221
132 OOB 0.442308 0.722892
133 S8M 0.442308 0.831169
134 ADP VO4 0.441176 0.702381
135 VO4 ADP 0.441176 0.702381
136 ANP 0.44 0.674419
137 TAT 0.44 0.686047
138 WAQ 0.439252 0.75
139 ARG AMP 0.438596 0.727273
140 YLC 0.435897 0.755814
141 AAT 0.435644 0.797468
142 3OD 0.435185 0.73494
143 1ZZ 0.435185 0.755814
144 NVA 2AD 0.434343 0.815789
145 DLL 0.433962 0.722892
146 00A 0.433962 0.689655
147 7MD 0.433628 0.715909
148 ATF 0.431373 0.666667
149 SO8 0.43 0.792208
150 3UK 0.429907 0.714286
151 A6D 0.429907 0.72619
152 5SV 0.428571 0.741176
153 AMP DBH 0.428571 0.714286
154 WSA 0.42735 0.692308
155 TYM 0.42735 0.746988
156 9SN 0.427273 0.681818
157 AHZ 0.426087 0.755814
158 A A 0.425926 0.710843
159 3NZ 0.425926 0.807692
160 P5A 0.425926 0.691489
161 PR8 0.425926 0.744186
162 A1R 0.424528 0.709302
163 2A5 0.424242 0.674419
164 7MC 0.423729 0.719101
165 7D5 0.422222 0.658824
166 FYA 0.422018 0.722892
167 JB6 0.422018 0.709302
168 AYB 0.421488 0.75
169 PLP AAD 0.419355 0.764045
170 A22 0.419048 0.682353
171 MAP 0.419048 0.659091
172 2AM 0.417582 0.666667
173 TAD 0.417391 0.712644
174 A3P 0.416667 0.686747
175 ADP BMA 0.416667 0.714286
176 25A 0.415094 0.690476
177 YLA 0.413223 0.719101
178 ADQ 0.411215 0.694118
179 48N 0.410256 0.72093
180 0XU 0.41 0.824324
181 NAD IBO 0.406504 0.717647
182 7D3 0.40625 0.643678
183 PAP 0.405941 0.678571
184 OVE 0.404255 0.662791
185 4UV 0.403509 0.697674
186 ALF ADP 3PG 0.403361 0.712644
187 AF3 ADP 3PG 0.403361 0.712644
188 LA8 ALF 3PG 0.403361 0.712644
189 3AD 0.402299 0.783784
190 CMP 0.402062 0.691358
191 2BA 0.402062 0.682927
192 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3M6W; Ligand: SAM; Similar sites found: 509
This union binding pocket(no: 1) in the query (biounit: 3m6w.bio2) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1BTN I3P 0.00002642 0.59171 None
2 1UO4 PIH 0.004722 0.45199 None
3 1UO5 PIH 0.01403 0.43615 None
4 2E1A MSE 0.002984 0.41337 None
5 1ZJ6 G3D 0.0001951 0.44749 1.06952
6 3S1S SAH 0.000001686 0.58019 1.07759
7 4M5P MLA 0.007725 0.44093 1.2285
8 4M5P 23W 0.004752 0.43536 1.2285
9 1UW1 ADP 0.0027 0.42634 1.25
10 1H16 PYR 0.01904 0.40672 1.2931
11 2BLE 5GP 0.01872 0.40903 1.3624
12 1TUF AZ1 0.00225 0.41272 1.38249
13 3L6R MLI 0.001918 0.44623 1.44509
14 3NNF AKG 0.0146 0.40046 1.45349
15 2O66 FLC 0.008889 0.40445 1.48148
16 1GPJ CIT 0.0007209 0.45774 1.48515
17 3C6K SPD 0.005109 0.43653 1.50862
18 4C2G ALA ALA ALA ALA 0.000183 0.46119 1.56951
19 2EJU SAH 0.0001649 0.4803 1.5873
20 1MUU NAD 0.01401 0.40468 1.6055
21 3E5P PPI 0.01823 0.42606 1.61725
22 1WRA PC 0.006285 0.42278 1.62338
23 4LWP SAH 0.0003372 0.46637 1.63043
24 3JDW ORN 0.001571 0.40469 1.65485
25 2VDJ HSE 0.002448 0.44899 1.66113
26 4A6D SAM 0.0006083 0.42584 1.69972
27 1O9U ADZ 0.0004559 0.49338 1.71429
28 4WBD CIT 0.004873 0.43484 1.72414
29 1YBH FAD 0.001964 0.43353 1.72414
30 1X87 NAD 0.003677 0.42707 1.72414
31 4O8A 2OP 0.01114 0.42483 1.72414
32 4KRG SAH 0.002861 0.42263 1.72414
33 3L24 GOA 0.0161 0.41689 1.72414
34 2CKM AA7 0.005994 0.4165 1.72414
35 4OE4 NAD 0.003809 0.41231 1.72414
36 4RPM HXC 0.04463 0.40854 1.72414
37 2YYJ FAD 0.03783 0.40594 1.72414
38 2YYJ 4HP 0.03783 0.40594 1.72414
39 1SC6 NAD 0.01002 0.41792 1.73267
40 2BO4 FLC 0.01378 0.40721 1.76322
41 4HA6 FAD 0.001696 0.44019 1.77165
42 3FPZ AHZ 0.00358 0.44901 1.84049
43 4DCM SAM 0.00005806 0.49542 1.86667
44 1F8F NAD 0.01592 0.40069 1.88679
45 4USQ FAD 0.002985 0.42077 1.93906
46 4N4J HG1 0.01337 0.4013 1.93966
47 1UXG FUM 0.001119 0.44197 1.94175
48 1UXG NAD 0.001119 0.44197 1.94175
49 3U1T MLI 0.007161 0.42019 1.94175
50 2P69 PLP 0.001625 0.43565 1.96078
51 4KCF AKM 0.008056 0.41835 1.98238
52 4KCF FMN 0.0007648 0.40686 1.98238
53 2OYS FMN 0.0006132 0.42777 2.06612
54 3B1F NAD 0.0008853 0.42396 2.06897
55 1U2Z SAH 0.0021 0.43823 2.07852
56 1UKW FAD 0.004593 0.41695 2.11082
57 2G5C NAD 0.01456 0.40779 2.13523
58 2FZW NAD 0.009768 0.42974 2.14477
59 1XOC VAL ASP SER LYS ASN THR SER SER TRP 0.001131 0.44401 2.15517
60 1UWK URO 0.005515 0.44379 2.15517
61 1V5F TPP 0.017 0.43956 2.15517
62 1V5F FAD 0.017 0.43956 2.15517
63 2YIV YIV 0.004212 0.43784 2.15517
64 4PIO AVI 0.01054 0.41804 2.16718
65 4PIO SAH 0.01113 0.41804 2.16718
66 2YCD GTB 0.002569 0.40604 2.17391
67 2C5S AMP 0.006464 0.4001 2.17918
68 1E7S NAP 0.004639 0.41098 2.18069
69 1NW5 SAM 0.0003922 0.46562 2.19436
70 1XVV CCQ 0.01132 0.40367 2.20588
71 4LIT AKG 0.00766 0.40719 2.2113
72 1TOI HCI 0.004271 0.40841 2.27273
73 4C6F NCD 0.003135 0.40752 2.29008
74 4C6F DOR 0.003135 0.40752 2.29008
75 1Y42 TYR 0.007402 0.40261 2.29592
76 3RHZ UDP 0.002421 0.40242 2.35988
77 1R27 MGD 0.0002225 0.46676 2.37069
78 1V7W NDG 0.001079 0.40019 2.37069
79 1V7W NAG 0.001079 0.40019 2.37069
80 3S5W FAD 0.0177 0.40495 2.37581
81 1U3U BNF 0.01931 0.41424 2.40642
82 1D1T NAD 0.007436 0.4241 2.41287
83 2OBF F83 0.009322 0.42984 2.42215
84 3SIX GDP 0.002803 0.40463 2.42424
85 4K5S FAD 0.001002 0.43767 2.42537
86 4K5S PM0 0.002598 0.43741 2.42537
87 1T57 FMN 0.01174 0.40229 2.42718
88 2DPM SAM 0.00001543 0.53384 2.46479
89 2F2U M77 0.0019 0.41584 2.48756
90 1SAY PYR 0.009792 0.42071 2.49307
91 1YS4 NAP 0.0004121 0.43598 2.54237
92 3TA2 ATP 0.005225 0.41083 2.54237
93 1JA9 NDP 0.01775 0.41488 2.55474
94 2C4I BTN 0.000829 0.41438 2.58303
95 1GJW GLC 0.001847 0.44698 2.58621
96 1RZM E4P 0.01487 0.4057 2.66272
97 1RZM PEP 0.006899 0.40387 2.66272
98 1QZZ SAM 0.0003547 0.43241 2.6738
99 4GKV NAD 0.01779 0.40823 2.67857
100 1XX4 BAM 0.007914 0.40396 2.68199
101 4G28 0W8 0.0007431 0.43719 2.68456
102 3CQ5 PMP 0.001381 0.42658 2.71003
103 9LDT OXM 0.009018 0.43745 2.71084
104 9LDB NAD 0.003299 0.41533 2.71084
105 1V35 NAI 0.007046 0.41372 2.73556
106 4DQ2 BTX 0.0009856 0.43231 2.7439
107 3JWH SAH 0.004698 0.40245 2.76498
108 1TIW TFB 0.001306 0.43935 2.80172
109 1TIW FAD 0.001306 0.43935 2.80172
110 4EDF UPG 0.04174 0.40152 2.80172
111 3QOX SAH 0.001039 0.45227 2.8169
112 1UZN NAP 0.001977 0.40121 2.83401
113 3PNL ADP 0.002699 0.40642 2.8436
114 4B7E OGA 0.005139 0.41452 2.86533
115 3P3N AKG 0.01285 0.4029 2.86533
116 3F3E LEU 0.002983 0.42425 2.89017
117 1HEX NAD 0.001586 0.42308 2.89855
118 1KBJ FMN 0.0005755 0.43619 2.91262
119 1A8S PPI 0.002061 0.41199 2.9304
120 4NTD FAD 0.001068 0.44276 2.94118
121 2YVF NAD 0.00325 0.44199 2.94118
122 2YVF FAD 0.003125 0.44199 2.94118
123 1Z42 HBA 0.004781 0.46891 2.95858
124 1Z44 NPO 0.04407 0.40885 2.95858
125 1KTC NGA 0.001017 0.43782 2.96296
126 2WCI GSH 0.001482 0.43734 2.96296
127 3MTW M3R 0.00171 0.4034 2.97767
128 4KRI SAH 0.001495 0.44134 3.00231
129 3OIG IMJ 0.001745 0.42845 3.00752
130 3G2O SAM 0.0002202 0.45404 3.01003
131 3CEV ARG 0.003624 0.41004 3.01003
132 4WVH ASP HIS ASP ALA HIS ALA 0.001095 0.43055 3.01724
133 3WE0 FAD 0.005517 0.41982 3.01724
134 1HSJ GLC 0.03142 0.41696 3.01724
135 4QVH COA 0.005915 0.40102 3.01724
136 2HW1 ANP 0.001353 0.4154 3.02013
137 2QCX PF1 0.01012 0.40205 3.04183
138 1F74 NAY 0.001263 0.40799 3.07167
139 2YBQ UP2 0.003689 0.41955 3.08219
140 2AOT SAH 0.006446 0.4048 3.08219
141 4TQG NDP 0.006161 0.42414 3.09598
142 1U7Z PMT 0.006583 0.40639 3.09735
143 1PEA ACM 0.001068 0.46603 3.11688
144 4I9A NCN 0.004539 0.40742 3.125
145 5MPT SAH 0.002037 0.44881 3.1401
146 1RYI GOA 0.003816 0.46682 3.14136
147 1TV5 ORO 0.001579 0.40125 3.16027
148 2DFV NAD 0.003927 0.43192 3.17003
149 4O1M NAD 0.002967 0.41574 3.1746
150 4HZD COA 0.002343 0.42601 3.19149
151 5THY SAH 0.001299 0.45016 3.20988
152 3GTD MLI 0.002255 0.42964 3.23276
153 3LZW FAD 0.01622 0.41427 3.23276
154 3LZW NAP 0.03148 0.41395 3.23276
155 2GSD NAD 0.0003004 0.46041 3.23383
156 1DLJ NAI 0.03725 0.40548 3.23383
157 1DLJ UGA 0.03725 0.40548 3.23383
158 3PNA CMP 0.0007982 0.43597 3.24675
159 2WA2 SAM 0.0001506 0.47965 3.26087
160 3F81 STT 0.001749 0.46458 3.27869
161 3O7B SAH 0.0005655 0.40691 3.27869
162 2J7T 274 0.004588 0.40724 3.31126
163 2Z9V PXM 0.003171 0.41766 3.31633
164 3ELW GP3 0.0002881 0.50389 3.33333
165 3ELW SAM 0.0002732 0.50389 3.33333
166 2FOI JPA 0.003017 0.40816 3.34572
167 1SOW NAD 0.02307 0.4006 3.35366
168 3T7S SAM 0.008507 0.40341 3.35821
169 2ZIF SAM 0.00007089 0.49914 3.367
170 2NZ2 ASP 0.006308 0.40546 3.38983
171 4IOK XPO 0.001995 0.41294 3.39893
172 4IOK ADP 0.002703 0.41294 3.39893
173 4N7C AEF 0.007451 0.41941 3.40909
174 3LKZ SFG 0.0001135 0.48992 3.42679
175 1OTH PAO 0.00178 0.42683 3.42679
176 2R42 FPS 0.0005256 0.4281 3.44828
177 3A1I UNU 0.001961 0.41532 3.44828
178 1ZED PNP 0.009192 0.41525 3.44828
179 1T8U UAP SGN IDS SGN 0.005792 0.41408 3.44828
180 1V59 FAD 0.02712 0.40941 3.44828
181 3QDT A2G GAL 0.000482 0.48238 3.4965
182 3QDY A2G GAL 0.0006662 0.47573 3.4965
183 3QDY CBS 0.008666 0.41642 3.4965
184 4POO SAM 0.00002241 0.53081 3.5
185 1OLS TDP 0.003721 0.42756 3.5
186 1Y2W NAG 0.0102 0.40732 3.52113
187 3DG6 MUC 0.002425 0.40242 3.54223
188 3VYW SAM 0.000002862 0.5113 3.57143
189 2P41 SAH 0.0002273 0.47404 3.60656
190 2DWU DGL 0.006045 0.40125 3.62319
191 4OYA 1VE 0.00907 0.43945 3.66379
192 1WDA BAG 0.003453 0.41087 3.66379
193 1NVU GTP 0.01839 0.40666 3.66379
194 3DXY SAM 0.0006396 0.43848 3.66972
195 1Q3P GLU ALA GLN THR ARG LEU 0.00235 0.41747 3.66972
196 3SHR CMP 0.001974 0.4152 3.67893
197 4LO6 SIA GAL 0.01166 0.41362 3.68421
198 3FPF MTA 0.0000928 0.5243 3.69128
199 4E28 9MZ 0.006476 0.41598 3.69231
200 4W6Z ETF 0.005526 0.4399 3.7464
201 4TMK T5A 0.003704 0.41471 3.75587
202 4B16 NAG 0.003434 0.45914 3.7594
203 1A5Z NAD 0.009441 0.40663 3.76176
204 1C0I FAD 0.0004012 0.46715 3.85675
205 1C0I BE2 0.0004012 0.46715 3.85675
206 1WVC CTP 0.009149 0.43364 3.861
207 2XVE FAD 0.007996 0.42573 3.87931
208 1V6A TRE 0.003034 0.44479 3.91566
209 3ICC NAP 0.001327 0.43169 3.92157
210 3EVF GTA 0.0002749 0.5014 3.97112
211 3EVF SAH 0.0002495 0.49967 3.97112
212 4B9E FAH 0.001203 0.45545 3.98671
213 2Q3M MLA 0.009787 0.42761 3.98773
214 3EVG SAH 0.0001647 0.48032 4
215 1Y7P RIP 0.006203 0.42987 4.03587
216 2A92 NAI 0.01596 0.40827 4.04984
217 3HVJ 705 0.00003435 0.54252 4.0724
218 2PX8 SAH 0.0002046 0.4761 4.08922
219 4JLV ADP 0.04187 0.40625 4.08922
220 4MIG G3F 0.03821 0.4042 4.09483
221 1B9I PXG 0.00139 0.41866 4.12371
222 1YHM AHD 0.004684 0.41623 4.14365
223 2C7G ODP 0.003064 0.43861 4.16667
224 2C7G FAD 0.01254 0.41422 4.16667
225 2W3L DRO 0.02249 0.40966 4.16667
226 4NEC SAH 0.008715 0.4027 4.16667
227 3ZPG 5GP 0.03152 0.40233 4.18848
228 3VPH OXM 0.01286 0.41611 4.19355
229 3VPH NAD 0.02051 0.40417 4.19355
230 1GV0 NAD 0.01886 0.40244 4.19355
231 3BY8 MLT 0.01147 0.41085 4.22535
232 3S9K CIT 0.03306 0.4266 4.23729
233 1KOL NAD 0.004933 0.43727 4.27136
234 2PP3 LGT 0.0005442 0.42573 4.27136
235 1LSS NAD 0.01141 0.40119 4.28571
236 1MVN PCO 0.02183 0.40462 4.30622
237 4RJK PYR 0.005479 0.43243 4.31034
238 2PT9 2MH 0.0006435 0.47731 4.36137
239 2PT9 S4M 0.0003551 0.47731 4.36137
240 3IL6 B83 0.001227 0.41495 4.36137
241 1Z3C SA8 0.01283 0.41038 4.36242
242 1Y1A GSH 0.01439 0.43733 4.37158
243 2PNZ UDP 0.002378 0.41345 4.41767
244 1O5I NAD 0.006496 0.41056 4.41767
245 2DVZ GLU 0.001519 0.41955 4.4586
246 5ULP KB1 0.006104 0.41136 4.47761
247 2PAR TMP 0.0114 0.40681 4.47761
248 4R33 SAH 0.008258 0.40261 4.52381
249 4R33 TRP 0.008258 0.40261 4.52381
250 1A8R GTP 0.001451 0.41235 4.52489
251 3AHC TPP 0.005795 0.40476 4.52586
252 1KPH SAH 0.01313 0.40005 4.52962
253 1CKM GTP 0.005886 0.40171 4.54545
254 2ZL4 ALA ALA ALA ALA 0.02339 0.40014 4.59184
255 3L9W GSH 0.008744 0.41697 4.60048
256 3L9W AMP 0.01057 0.41562 4.60048
257 3BXO SAM 0.006648 0.40035 4.60251
258 3VPD ANP 0.001343 0.41552 4.62633
259 4JWX 1N4 0.000925 0.43949 4.64286
260 1XCL SAH 0.0002552 0.49366 4.68085
261 1I1Q TRP 0.003645 0.40994 4.6875
262 3ZGE ASP 0.01676 0.40935 4.74138
263 4C3Y FAD 0.03058 0.40348 4.74138
264 2RCN GDP 0.004654 0.40096 4.7486
265 3FS8 TDR 0.01244 0.42396 4.7619
266 3FS8 ACO 0.01662 0.41939 4.7619
267 1DXY COI 0.002143 0.46023 4.8048
268 3QWI NAP 0.01099 0.41718 4.81482
269 3QWI CUE 0.01798 0.41489 4.81482
270 2HVW DDN 0.0008263 0.40995 4.8913
271 3RO7 TDR 0.002077 0.4187 4.90566
272 4NAO AKG 0.002747 0.43914 4.90798
273 1NML CIT 0.003346 0.41671 4.90798
274 2DTX BMA 0.001397 0.43933 4.92424
275 2I7C AAT 0.0004947 0.48142 4.947
276 1G0N NDP 0.01604 0.41452 4.947
277 1G0N PHH 0.02091 0.41166 4.947
278 2C31 TZD 0.001675 0.46005 4.9569
279 2C31 ADP 0.001618 0.46005 4.9569
280 3OND ADN 0.005249 0.42423 4.9569
281 3OND NAD 0.01845 0.41936 4.9569
282 2QIA U20 0.01907 0.40496 4.96183
283 2VQ5 LDP 0.00306 0.45259 4.97512
284 2VQ5 HBA 0.001904 0.44638 4.97512
285 1SAZ ACP 0.0369 0.40447 4.98688
286 3Q3C NAD 0.01038 0.41541 5.01672
287 1SC3 MLI 0.003106 0.4441 5.05618
288 4N49 SAM 0.00002066 0.52573 5.14019
289 2NLI LAC 0.01112 0.41266 5.16304
290 2NLI FMN 0.01112 0.41266 5.16304
291 3PT9 SAH 0.000003932 0.55308 5.17241
292 2NS1 ADP 0.004233 0.41434 5.17241
293 1QH9 LAC 0.01353 0.40191 5.17241
294 1YY5 FAD 0.0398 0.40026 5.17241
295 3V1U NAD 0.00181 0.41782 5.19481
296 4USS GSH 0.0009156 0.43967 5.23077
297 3WBF NAP 0.001741 0.42304 5.2459
298 3WBF API 0.004603 0.41234 5.2459
299 1CBF SAH 0.001672 0.40375 5.26316
300 1MV8 NAD 0.009022 0.41361 5.27523
301 3VSE SAH 0.001346 0.42225 5.27638
302 2VHW NAI 0.003274 0.44585 5.30504
303 1C3V NDP 0.004323 0.41088 5.30612
304 3GCZ SAM 0.00006174 0.49944 5.31915
305 1EDO NAP 0.01274 0.41295 5.32787
306 1ULE GLA GAL NAG 0.0008075 0.47178 5.33333
307 2AMV BIN 0.001297 0.45048 5.34442
308 1GSA GSH 0.006114 0.41616 5.37975
309 1GSA ADP 0.01918 0.40149 5.37975
310 1FIQ SAL 0.002478 0.42136 5.38793
311 1FIQ FAD 0.004224 0.41497 5.38793
312 1FIQ MTE 0.005841 0.40463 5.38793
313 1I0Z OXM 0.006201 0.43743 5.40541
314 1OAA OAA 0.004797 0.42223 5.40541
315 1E6E FAD 0.0259 0.40239 5.46875
316 3UEC ALA ARG TPO LYS 0.003837 0.43254 5.47945
317 3A27 SAM 0.001325 0.42118 5.51471
318 4F8L GAL 0.004009 0.46572 5.51724
319 3DDC GNP 0.003429 0.40758 5.52147
320 1P1C SAH 0.0009581 0.45388 5.52764
321 1WVG APR 0.00147 0.42116 5.57103
322 1V8B NAD 0.006526 0.4314 5.60345
323 1GTE FAD 0.01632 0.42987 5.60345
324 3LM9 ADP 0.0004785 0.43307 5.62914
325 2OFD NGA 0.00538 0.41951 5.6338
326 2OFE NAG 0.01264 0.40321 5.6338
327 2XDQ MGX 0.01952 0.41272 5.65217
328 2YX1 SFG 0.0002035 0.4648 5.65476
329 1YOA FMN 0.003016 0.47244 5.66038
330 1FP2 SAH 0.0003838 0.43118 5.68182
331 1JGS SAL 0.009092 0.4464 5.7971
332 3Q9T FAY 0.002552 0.42799 5.81897
333 3DAG FEG 0.001217 0.42419 5.86592
334 3KMT SAH 0.001835 0.40677 5.88235
335 4ITU NAI 0.02319 0.4016 5.94796
336 4ITU 1HS 0.03471 0.4016 5.94796
337 3R35 4CO 0.002709 0.41858 5.96026
338 4Q3F TLA 0.008292 0.40311 5.98291
339 4JCA CIT 0.003959 0.45595 5.98802
340 1II5 GLU 0.0001346 0.40103 6.00858
341 2DKH 3HB 0.006808 0.41236 6.03448
342 2DKH FAD 0.008714 0.40172 6.03448
343 3TKA SAM 0.000001799 0.57384 6.05187
344 3TKA CTN 0.03147 0.42178 6.05187
345 1QAN SAH 0.0000009961 0.58813 6.14754
346 3K3G MMU 0.005351 0.41103 6.17647
347 2DTJ THR 0.0003748 0.44277 6.17978
348 1RYD GLC 0.003147 0.42972 6.20155
349 3ZF8 GDP 0.004491 0.40156 6.22951
350 3TFC PEP 0.003528 0.41577 6.23377
351 1QF5 RPL 0.001154 0.4507 6.2645
352 1QF5 GDP 0.001154 0.4507 6.2645
353 1A59 CIT 0.007498 0.41928 6.34921
354 4HXY NDP 0.02117 0.40124 6.39269
355 4HKP TKW 0.007907 0.41015 6.41026
356 1DL7 NCH 0.03938 0.41155 6.42202
357 1I9G SAM 0.00001662 0.53002 6.42857
358 1I2B USQ 0.02275 0.40285 6.43564
359 1I2B UPG 0.02275 0.40285 6.43564
360 1I2B NAD 0.02275 0.40285 6.43564
361 4KIB SAH 0.002605 0.42444 6.44258
362 2A14 SAH 0.004976 0.41936 6.46388
363 3WO0 ALA 0.003885 0.41867 6.46552
364 3WO0 ADP 0.003885 0.41867 6.46552
365 3CQD ATP 0.0004042 0.45799 6.47249
366 3GE7 AFQ 0.00003653 0.49263 6.47668
367 2YC5 6BC 0.00793 0.40556 6.57895
368 2X61 CH 0.0136 0.40054 6.58915
369 1R18 SAH 0.0002103 0.48209 6.60793
370 3BHO B4P 0.002348 0.46767 6.73077
371 2Y7P SAL 0.003268 0.41713 6.88073
372 2ZWS PLM 0.0001262 0.54713 6.89655
373 3GGO NAI 0.02176 0.4108 6.89655
374 1VDC FAD 0.002436 0.43765 6.90691
375 3RGG AIR 0.000633 0.40513 6.91824
376 3Q87 SAM 0.0002455 0.481 7.05882
377 3TCT 3MI 0.002568 0.44014 7.08661
378 1B74 DGN 0.00437 0.43708 7.08661
379 3RFV 15L 0.006957 0.41888 7.11611
380 3RFV NAI 0.01096 0.41103 7.11611
381 1T26 GBD 0.008359 0.4392 7.14286
382 2QQF A1R 0.0005347 0.43737 7.14286
383 1T26 NAI 0.02586 0.40796 7.14286
384 1SS4 GSH 0.002042 0.49342 7.18954
385 1SS4 CIT 0.03111 0.44593 7.18954
386 1M5B BN1 0.003912 0.43578 7.22433
387 1B8U NAD 0.001585 0.41293 7.29483
388 1B8U OAA 0.005976 0.40679 7.29483
389 3MD0 GDP 0.002876 0.414 7.32394
390 3H2B SAH 0.0008539 0.45037 7.38916
391 3EW2 BTN 0.003625 0.41003 7.40741
392 1OFH ADP 0.01582 0.41142 7.47126
393 2Q1A 2KT 0.004082 0.42477 7.50853
394 1OMZ UD2 0.01231 0.40593 7.50853
395 1GAD NAD 0.001723 0.4202 7.57576
396 1WGC SIA GAL BGC 0.04392 0.40158 7.60234
397 2ALG HP6 0.002714 0.40452 7.6087
398 2ALG DAO 0.002714 0.40452 7.6087
399 2Q8H TF4 0.0002068 0.51032 7.61671
400 1OGD RIP 0.002963 0.41886 7.63359
401 2FWP ICR 0.002473 0.42511 7.65027
402 2VAR KDG 0.001193 0.41837 7.66773
403 2VAR KDF 0.001835 0.41145 7.66773
404 3NUG NAD 0.008287 0.42063 7.69231
405 1Q0S SAH 0.0000352 0.52177 7.72201
406 1ECC PCP 0.002059 0.41244 7.75862
407 3LTW HLZ 0.00316 0.42964 7.85714
408 1DL5 SAH 0.00002035 0.53679 7.88644
409 2IMP NAI 0.01937 0.41756 7.97414
410 3CF6 SP1 0.0008646 0.41374 7.97414
411 1Q3Q ANP 0.01413 0.41278 7.97414
412 2JBH 5GP 0.005464 0.40299 8
413 4PLG OXM 0.0001247 0.47783 8.08383
414 1QO0 BMD 0.003204 0.42938 8.16327
415 3A2Q ACA ACA 0.001086 0.41258 8.18966
416 3QV9 QV7 0.006951 0.40897 8.18966
417 3D3W NAP 0.00808 0.40057 8.19672
418 1NF8 BOG 0.001958 0.44583 8.21256
419 3SQG COM 0.00964 0.43594 8.24373
420 1NU4 MLA 0.005569 0.40266 8.24742
421 3MQ2 SAH 0.005895 0.4086 8.25688
422 1G8S MET 0.006426 0.41613 8.26087
423 3P0K FAD 0.002049 0.41075 8.27068
424 3A25 SAM 0.003682 0.41977 8.30565
425 1O68 KIV 0.001897 0.42677 8.36364
426 1FBL HTA 0.0002765 0.44781 8.37838
427 3LST SAH 0.0002225 0.44537 8.40517
428 4KQI RBZ 0.007621 0.40153 8.42697
429 4KQI NIO 0.007621 0.40153 8.42697
430 3SJ0 DXC 0.0159 0.40437 8.4507
431 1TDF NAP 0.002361 0.45312 8.5443
432 1TDF FAD 0.00167 0.44333 8.5443
433 1DQX BMP 0.003919 0.42233 8.61423
434 2HNK SAH 0.0006379 0.45814 8.62069
435 3K56 IS3 0.0008248 0.40968 8.64662
436 1G55 SAH 0.000003219 0.51771 8.74636
437 2RGO FAD 0.01572 0.41395 8.83621
438 1XE7 GUN 0.01519 0.41815 8.86699
439 3GEG NAD 0.003272 0.41133 8.90688
440 1LTH NAD 0.001356 0.45143 9.09091
441 2VBQ BSJ 0.003212 0.41954 9.09091
442 3PFG SAM 0.00008401 0.48839 9.12547
443 3PFG TLO 0.01271 0.42137 9.12547
444 1B5E DCM 0.001858 0.42149 9.34959
445 1JG3 ADN 0.00005378 0.41582 9.3617
446 4P9Z NMI PTR 02K ASN NH2 0.004364 0.412 9.40171
447 3MAG 3MA 0.005314 0.44934 9.44625
448 1PL6 572 0.009663 0.41867 9.48276
449 1PL6 NAD 0.005994 0.41394 9.48276
450 3CH5 GDP 0.001645 0.4132 9.61539
451 3C1O NAP 0.0002109 0.45043 9.65732
452 2PWY SAH 0.000003041 0.56845 9.68992
453 1T0S BML 0.01089 0.41827 9.69697
454 4COQ SAN 0.006621 0.41556 9.7166
455 1H2B NAJ 0.0208 0.40388 9.7493
456 3MCT SAH 0.0009873 0.42033 9.76431
457 1N07 FMN 0.01562 0.40871 9.81595
458 1N07 ADP 0.008073 0.40628 9.81595
459 1LNX URI 0.003003 0.41862 9.87654
460 2V5E SCR 0.007417 0.44184 9.90099
461 2GJ3 FAD 0.003233 0.415 10
462 4BLW SAH 0.00002653 0.53144 10.0346
463 4BLW AMP 0.00005236 0.52938 10.0346
464 4BMO FMN 0.002411 0.41323 10.084
465 1KYZ SAH 0.006182 0.40768 10.137
466 1G60 SAM 0.0004006 0.46521 10.3846
467 1L3I SAH 0.00005755 0.5158 10.4167
468 2HMT NAI 0.006386 0.4144 10.4167
469 1WUR 8DG 0.003076 0.40436 10.4545
470 1IY8 NAD 0.02173 0.4007 10.4869
471 1JN2 SFP 0.01281 0.45222 10.5485
472 2XVM SAH 0.002118 0.4207 10.5528
473 1F3L SAH 0.0002169 0.48147 10.5919
474 4R6W PC 0.004898 0.45137 10.8527
475 4R6W SAH 0.002173 0.4495 10.8527
476 1QD0 RR6 0.001972 0.41029 10.9375
477 3QP6 HL6 0.001407 0.41091 10.9434
478 2Y6P CTP 0.0004894 0.43834 11.1111
479 1H9G COA MYR 0.001459 0.42288 11.1111
480 2CSN CKI 0.001359 0.42242 11.4478
481 3FXU TSU 0.001544 0.41871 11.4754
482 2Q37 3AL 0.0008645 0.44723 11.6022
483 4FN4 NAD 0.007498 0.42143 11.811
484 3OU2 SAH 0.0001113 0.42346 11.9266
485 3P2E SAH 0.003289 0.42579 12
486 3C3Y SAH 0.0003916 0.46565 12.2363
487 2J8Z NAP 0.005104 0.4055 12.7119
488 1VE3 SAM 0.002085 0.43087 12.7753
489 2O07 MTA 0.007962 0.41754 12.8289
490 2O07 SPD 0.009059 0.41754 12.8289
491 3GM5 CIT 0.003218 0.4293 13.2075
492 1SBZ FMN 0.003326 0.41649 13.7056
493 2VDV SAM 0.0008092 0.44956 14.2276
494 1H2M OGA 0.001996 0.43839 15.3846
495 1QJC PNS 0.001427 0.45095 15.8228
496 4OBW SAM 0.001434 0.41973 15.9533
497 1YAG ATP 0.002459 0.40963 16
498 4DMG SAM 0.001421 0.44327 16.285
499 3H86 AP5 0.01966 0.40442 16.6667
500 3DZ6 M8E 0.009631 0.40098 17.9104
501 1EJE FMN 0.0008615 0.40144 18.2292
502 1HDR NAD 0.005674 0.42371 18.8525
503 3MB5 SAM 0.00001101 0.54282 19.2157
504 1H8G CHT 0.03945 0.41151 21.0526
505 4GQB 0XU 0.0000646 0.50962 22.7273
506 1X1T NAD 0.01713 0.41666 23.0769
507 1I1N SAH 0.0006256 0.46922 24.7788
508 4CCN OGA 0.006391 0.41623 25.7143
509 1SQF SAM 0.0000000005602 0.72558 27.2727
510 4GYW UDP 0.003244 0.4169 50
Pocket No.: 2; Query (leader) PDB : 3M6W; Ligand: SAM; Similar sites found: 38
This union binding pocket(no: 2) in the query (biounit: 3m6w.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3C6K MTA 0.005109 0.43653 1.50862
2 4UCI SAM 0.0005545 0.45883 1.92771
3 1UWK NAD 0.005515 0.44379 2.15517
4 5M67 NAD 0.01745 0.42136 2.15517
5 5M67 ADE 0.02087 0.41746 2.15517
6 5M67 3D1 0.02092 0.4174 2.15517
7 5E1M PRO PRO LYS ARG ILE ALA 0.007032 0.42761 2.48963
8 5E1M SAH 0.007032 0.42761 2.48963
9 5JJR SAH 0.00008757 0.46878 2.80172
10 5L53 NAP 0.007096 0.41231 3.08642
11 5E9W SAH 0.002687 0.41638 3.20513
12 5THZ SAH 0.00001181 0.54143 3.20988
13 5E72 SAM 0.000002201 0.57243 3.75723
14 4XUC SAM 0.0002634 0.49585 4.12844
15 4XUC 43G 0.0002634 0.49585 4.12844
16 3NJ4 AFX 0.04116 0.42937 4.13793
17 3NJ4 NAD 0.04192 0.42893 4.13793
18 5JGL SAM 0.008229 0.40212 4.15225
19 4ZGR NGA GAL 0.01976 0.40005 4.45344
20 5CUQ NSC 0.00004884 0.52774 4.49438
21 5MW4 5JU 0.0005126 0.48941 4.79042
22 5L4S 6KX 0.03015 0.40015 5.34591
23 5L4S NAP 0.03015 0.40015 5.34591
24 4PNE SAH 0.007292 0.4134 5.62914
25 5N5D SAM 0.001962 0.43406 5.75221
26 5ITV NAI 0.005843 0.42783 6.66667
27 3GGO ENO 0.02176 0.4108 6.89655
28 5BW4 SAM 0.00413 0.41551 7.11611
29 5DX1 SFG 0.00009231 0.5044 9.45559
30 5DWQ SFG 0.0003194 0.47763 9.45559
31 5DX0 SFG 0.0004438 0.47282 9.45559
32 5DX8 SFG 0.0002381 0.42387 9.45559
33 5DXA SFG 0.0002986 0.42084 9.45559
34 5E5U MLI 0.002188 0.46213 11.0553
35 5KVA SAM 0.00023 0.48032 13.3094
36 5FA8 SAM 0.0005484 0.41529 13.6646
37 5E8J SAH 0.004543 0.41557 18.1818
38 5FA5 MTA 0.001123 0.43845 25
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