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Receptor
PDB id Resolution Class Description Source Keywords
3JUC 1.2 Å EC: 2.3.2.4 HUMAN GAMMA-GLUTAMYLAMINE CYCLOTRANSFERASE COMPLEX WITH 5- OXOPROLINE HOMO SAPIENS CYCLOTRANSFERASE GAMMA-GLUTAMYLAMINE CYCLOTRANSFERASE GAMMA-GLUTAMYL-EPSILON-LYSINE EPSILON-(GAMMA-GLUTAMYL)- LYSINE OXOPROLINE 5-OXO-L-PROLINE CYCLOTRANSFERASE FOLDTRANSFERASE
Ref.: IDENTIFICATION AND CHARACTERIZATION OF {GAMMA}-GLUTAMYLAMINE CYCLOTRANSFERASE: AN ENZYME RESPONSIBLE FOR {GAMMA}-GLUTAMYL-{EPSILON}-LYSINE CATABOLISM J.BIOL.CHEM. V. 285 9642 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NO3 A:154;
A:155;
Invalid;
Invalid;
none;
none;
submit data
62.005 N O3 [N+](...
PCA A:1001;
Valid;
none;
submit data
129.114 C5 H7 N O3 C1CC(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3JUC 1.2 Å EC: 2.3.2.4 HUMAN GAMMA-GLUTAMYLAMINE CYCLOTRANSFERASE COMPLEX WITH 5- OXOPROLINE HOMO SAPIENS CYCLOTRANSFERASE GAMMA-GLUTAMYLAMINE CYCLOTRANSFERASE GAMMA-GLUTAMYL-EPSILON-LYSINE EPSILON-(GAMMA-GLUTAMYL)- LYSINE OXOPROLINE 5-OXO-L-PROLINE CYCLOTRANSFERASE FOLDTRANSFERASE
Ref.: IDENTIFICATION AND CHARACTERIZATION OF {GAMMA}-GLUTAMYLAMINE CYCLOTRANSFERASE: AN ENZYME RESPONSIBLE FOR {GAMMA}-GLUTAMYL-{EPSILON}-LYSINE CATABOLISM J.BIOL.CHEM. V. 285 9642 2010
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3JUC - PCA C5 H7 N O3 C1CC(=O)N[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3JUC - PCA C5 H7 N O3 C1CC(=O)N[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3JUC - PCA C5 H7 N O3 C1CC(=O)N[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PCA; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 PCA 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3JUC; Ligand: PCA; Similar sites found with APoc: 296
This union binding pocket(no: 1) in the query (biounit: 3juc.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 1MJH ATP None
2 1G16 GDP None
3 4CO3 ATP None
4 4MN7 SME None
5 1D4O NAP None
6 1JAY NAP None
7 2HMT NAI None
8 3I59 N6R None
9 3I54 CMP None
10 1DJL NAP None
11 2PN6 GLN None
12 3I59 N6S None
13 3R5W F42 None
14 1LK7 DER None
15 4PL9 ADP None
16 1RLJ FMN None
17 2WPU KYT None
18 1VL0 NAI None
19 5NM7 GLY None
20 4BX7 B4F None
21 4K6B GLU None
22 1IA9 ANP 1.30719
23 3MB5 SAM 1.30719
24 3HGM ATP 1.36054
25 4FE2 AIR 1.56863
26 1NM5 NAD 1.96078
27 5F7R GLC GLC 1.96078
28 4EDK GTP 1.96078
29 5BSH PRO 1.96078
30 1QMG APX 2.61438
31 4WUP 3UF 2.61438
32 4R6W PC 2.61438
33 1G3M A3P 2.61438
34 1G3M PCQ 2.61438
35 2C94 TSF 2.61438
36 5KKB BMA NAG MAN MAN MAN MAN MAN MAN MAN 2.61438
37 3QV1 NAD 2.61438
38 1V8B NAD 2.61438
39 1EQ2 NAP 2.61438
40 2Q1W NAD 3.26797
41 5A96 GTP 3.26797
42 1RPN NDP 3.26797
43 1J49 NAD 3.26797
44 1HKU NAD 3.26797
45 3H9E NAD 3.26797
46 1J0D 5PA 3.26797
47 3KCC CMP 3.26797
48 5WX3 COA 3.26797
49 3JZ4 NAP 3.26797
50 1CF2 NAP 3.26797
51 1LQA NDP 3.26797
52 4P6G 2FZ 3.53982
53 4M69 ANP 3.92157
54 2WPF FAD 3.92157
55 2WPF WPF 3.92157
56 3RS8 APR 3.92157
57 3VPH NAD 3.92157
58 3VPH OXM 3.92157
59 5FB3 NDP 3.92157
60 1YY5 FAD 3.92157
61 2QZS ADP 3.92157
62 2QZS 250 3.92157
63 2QZS GLC 3.92157
64 5WS9 AMP 3.92157
65 1V59 FAD 3.92157
66 4WB6 ATP 3.92157
67 2WZM NA7 3.92157
68 2JHP SAH 3.92157
69 3ZLB ANP 3.92157
70 2CDU ADP 3.92157
71 1RQL VSO 3.92157
72 2X06 NAD 3.92157
73 4G1V FAD 3.92157
74 3OJF NDP 3.92157
75 3OJF IMJ 3.92157
76 2C91 NAP 3.92157
77 6FDF SAH 3.92157
78 4MCC 21X 4.47154
79 4F2Q QUS 4.57516
80 4XDZ NDP 4.57516
81 5E4R NAP 4.57516
82 2VVL FAD 4.57516
83 4WOP CTP 4.57516
84 2ZIF SAM 4.57516
85 2VVM FAD 4.57516
86 2F59 INI 4.57516
87 3GD4 FAD 4.57516
88 4Z87 5GP 4.57516
89 5MW4 5JU 4.57516
90 2IXB NAD 4.57516
91 2IXB A2G 4.57516
92 3GD4 NAD 4.57516
93 3ZKK XYP XYP XYP XYP 4.57516
94 5LYH 7B8 4.57516
95 3FHI ANP 4.57516
96 4XYM COA 4.57516
97 3GDN FAD 4.57516
98 2C29 NAP 4.57516
99 2XZ9 PYR 4.57516
100 2PEZ DAT 4.57516
101 3AKK ADP 4.57516
102 1M4I COA 5.22876
103 1M4I KAN 5.22876
104 1T9D PYD 5.22876
105 1T9D FAD 5.22876
106 1T9D 1MM 5.22876
107 1T9D P25 5.22876
108 1M4I PAP 5.22876
109 4UTG ANP 5.22876
110 4J7H TRH 5.22876
111 5VN0 NAI 5.22876
112 2Q0L FAD 5.22876
113 4KQ6 DLZ 5.22876
114 3FV1 DYH 5.22876
115 4LY9 1YY 5.22876
116 4OOE NDP 5.22876
117 3ETG GTP 5.22876
118 1T9D P22 5.22876
119 3ETG NDP 5.22876
120 3ETG GLU 5.22876
121 3KDN CAP 5.22876
122 5WKC TP9 5.22876
123 5WKC AUJ 5.22876
124 5WKC FAD 5.22876
125 1GQ2 NAP 5.22876
126 3IA4 NDP 5.22876
127 6B5K TYD 5.22876
128 4E5N NAD 5.22876
129 5H86 BCO 5.22876
130 5BO9 CSF 5.22876
131 2I0K FAD 5.22876
132 5HWK BEZ 5.88235
133 5KF9 NAG 5.88235
134 5KF9 COA 5.88235
135 4AT0 FAD 5.88235
136 2NVK FAD 5.88235
137 2GQS C2R 5.88235
138 1D8C GLV 5.88235
139 1HSK FAD 5.88235
140 4RFM 3P6 5.88235
141 4C3Y ANB 5.88235
142 2QZZ EMF 5.88235
143 2QZZ NAP 5.88235
144 4OOP DUP 5.88235
145 4C3Y FAD 5.88235
146 4EDF UPG 5.88235
147 1NE6 SP1 5.88235
148 4QYS PLP SEP 5.88235
149 4FJU NAI 5.88235
150 2PTM CMP 5.88235
151 4UP3 NDP 5.88235
152 5KJZ PCG 6
153 1MO9 KPC 6.53595
154 1MO9 FAD 6.53595
155 5CMK GLU 6.53595
156 4HA9 NDP 6.53595
157 5I60 67W 6.53595
158 1FFU CDP 6.53595
159 5NC1 NAG 6.53595
160 4KQW NAP 6.53595
161 5NA1 FAD 6.53595
162 1P7T PYR 6.53595
163 3QVV A3P 6.53595
164 4F07 FAD 6.53595
165 3QVV 3QV 6.53595
166 5UY8 AMZ 6.53595
167 2B6N ALA PRO THR 6.53595
168 2GRU NAD 6.53595
169 6F5W KG1 6.53595
170 3CIP ATP 6.53595
171 2EIX FAD 6.53595
172 5KBF CMP 6.53595
173 1GY8 NAD 6.53595
174 4A22 TD4 6.53595
175 2GCG NDP 6.53595
176 5K8S CMP 6.75676
177 4MUV PCG 7.04225
178 4TM3 FAD 7.18954
179 1M5B BN1 7.18954
180 1VDC FAD 7.18954
181 1RM0 D6P 7.18954
182 4KGD FAD 7.18954
183 4KGD TDP 7.18954
184 3EB9 FLC 7.18954
185 4JDR FAD 7.18954
186 2P4Y C03 7.18954
187 1Q20 PLO 7.18954
188 1Q20 A3P 7.18954
189 4RSL FAD 7.18954
190 3OEN GLU 7.18954
191 3RG9 WRA 7.18954
192 2IVN ANP 7.18954
193 3TDC 0EU 7.18954
194 1EJB INJ 7.18954
195 5BW4 SAM 7.18954
196 4BLW SAH 7.18954
197 3RG9 NDP 7.18954
198 4WNP 3RJ 7.18954
199 5T9F TYR 7.18954
200 5T9F NAP 7.18954
201 2Q7V FAD 7.18954
202 1RC0 KT5 7.18954
203 1LDN NAD 7.18954
204 2Q28 TPP 7.18954
205 2G86 UMP 7.84314
206 2BHZ MAL 7.84314
207 1H9A NAP 7.84314
208 2X1L ADN 7.84314
209 1CX4 CMP 7.84314
210 6ECU SAH 7.84314
211 4AVB CMP 7.84314
212 5UPK GNP 8.33333
213 1P31 EPU 8.49673
214 6HKE MLT 8.49673
215 4XB2 NDP 8.49673
216 1P3D UMA 8.49673
217 4XB2 HSE 8.49673
218 3I6I NDP 8.49673
219 4M52 FAD 8.49673
220 5BJX UDP 8.49673
221 5BJX NAD 8.49673
222 6HKE LMR 8.49673
223 5Y9D FAD 8.49673
224 2A8X FAD 8.49673
225 4XOI GTP 8.49673
226 3OTI TYD 8.49673
227 5A04 NDP 8.49673
228 5A04 BGC 8.49673
229 4X1T UDP 9.15033
230 2IXE ATP 9.15033
231 5J60 FAD 9.15033
232 1NE7 AGP 9.15033
233 3A4T SFG 9.15033
234 2ZSC BTN 9.21986
235 2IHU TP9 9.80392
236 2YVJ FAD 9.80392
237 2YVJ NAI 9.80392
238 2PZM NAD 9.80392
239 2PZM UDP 9.80392
240 3KJS NAP 9.80392
241 3KJS DQ1 9.80392
242 5MQ6 NDP 9.80392
243 4WB7 ATP 9.80392
244 3GFS FMN 9.80392
245 1KRH FAD 9.80392
246 5FI3 NAP 9.80392
247 1YBH P22 10.4575
248 5H81 NAP 10.4575
249 3MQ2 SAH 10.4575
250 4PNE SAH 10.4575
251 3NOJ PYR 11.1111
252 4FBL SPD 11.1111
253 5ODQ 9SB 11.7647
254 5U5G NAP 11.7647
255 2W2X GSP 11.7647
256 2E1A MSE 12
257 4XQC 13D 12.4183
258 4XQC NAD 12.4183
259 1WDK NAD 12.4183
260 5ZZ6 NAD 12.4183
261 5NUF NAD 12.4183
262 5NUE NAD 12.4183
263 3LAD FAD 13.0719
264 5VJE GOS 13.0719
265 1Q19 SSC 13.0719
266 3SQP FAD 13.7255
267 2C6Q NDP 13.7255
268 1KYV RBF 14.3791
269 5Z21 NAI 15.0327
270 6ECW SAH 15.0327
271 3TKA SAM 15.6863
272 4J56 FAD 15.7895
273 3ZSN MIV 16.3399
274 4YRY FAD 16.3399
275 3EUT DCR 16.9935
276 1KOR ARG 17.6471
277 1KOR ANP 17.6471
278 4B63 FAD 17.6471
279 4B63 NAP 17.6471
280 4B63 ORN 17.6471
281 2ZXI FAD 17.6471
282 1KOR SIN 17.6471
283 3IBH GSH 17.6471
284 3S5W FAD 18.3007
285 1YKJ PHB 18.9542
286 4CYD CMP 19.0476
287 4JB1 FAD 19.6078
288 4JB1 NAP 19.6078
289 4DHY GLC 19.6078
290 6A3J NAI 20.2614
291 5W3K 9TY 20.915
292 5W3K NDP 20.915
293 2VQD AP2 21.5686
294 3WMX NAD 24.8366
295 5DX8 SFG 26.3158
296 4K39 SAM 44.4444
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