Receptor
PDB id Resolution Class Description Source Keywords
3GYU 2.4 Å NON-ENZYME: TRANSCRIPT_TRANSLATE NUCLEAR RECEPTOR DAF-12 FROM PARASITIC NEMATODE STRONGYLOIDE STERCORALIS IN COMPLEX WITH ITS PHYSIOLOGICAL LIGAND DAFACHD ELTA 7 STRONGYLOIDES STERCORALIS NUCLEAR RECEPTOR LIGAND BINDING DOMAIN DAFACHRONIC ACID SNEMATODE STRONGYLOIDES STERCORALIS DNA-BINDING METAL-BINNUCLEUS RECEPTOR TRANSCRIPTION TRANSCRIPTION REGULATIONZINC-FINGER
Ref.: IDENTIFICATION OF THE NUCLEAR RECEPTOR DAF-12 AS A THERAPEUTIC TARGET IN PARASITIC NEMATODES. PROC.NATL.ACAD.SCI.USA V. 106 9138 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DL7 A:200;
 Valid;
 none;
 submit data
414.621 C27 H42 O3 C[C@H...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3GYT 2.4 Å NON-ENZYME: TRANSCRIPT_TRANSLATE NUCLEAR RECEPTOR DAF-12 FROM PARASITIC NEMATODE STRONGYLOIDES STERCORALIS IN COMPLEX WITH ITS PHYSIOLOGICALL IGAND DAFACHRONIC ACID DELTA 4 STRONGYLOIDES STERCORALIS NUCLEAR RECEPTOR LIGAND BINDING DOMAIN DAFACHRONIC ACID SRC1 NEMATODE STRONGYLOIDES STERCORALIS DNA-BINDING METAL-BINDING NUCLEUS RECEPTOR TRANSCRIPTION TRANSCRIPTION REGULATION ZINC ZINC-FINGER
Ref.: IDENTIFICATION OF THE NUCLEAR RECEPTOR DAF-12 AS A THERAPEUTIC TARGET IN PARASITIC NEMATODES. PROC.NATL.ACAD.SCI.USA V. 106 9138 2009
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 308 families.
1 3GYU - DL7 C27 H42 O3 C[C@H](CCC....
2 3GYT - DL4 C27 H42 O3 C[C@H](CCC....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 266 families.
1 3GYU - DL7 C27 H42 O3 C[C@H](CCC....
2 3GYT - DL4 C27 H42 O3 C[C@H](CCC....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 220 families.
1 3GYU - DL7 C27 H42 O3 C[C@H](CCC....
2 3GYT - DL4 C27 H42 O3 C[C@H](CCC....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: DL7; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 DL7 1 1
2 D7S 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: DL7; Similar ligands found: 12
No: Ligand Similarity coefficient
1 XCA 0.9430
2 CLR 0.9388
3 K2B 0.9365
4 HC3 0.9343
5 DL4 0.9311
6 HCD 0.9138
7 ERG 0.9134
8 5JK 0.9103
9 HCR 0.9045
10 0T9 0.8993
11 LAN 0.8805
12 98H 0.8653
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3GYT; Ligand: DL4; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3gyt.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback