Receptor
PDB id Resolution Class Description Source Keywords
3GL6 1.9 Å EC: 1.14.11.- CRYSTAL STRUCTURE OF JARID1A-PHD3 COMPLEXED WITH H3(1-9) K4ME3 PEPTIDE HOMO SAPIENS PHD FINGERH3(1-9)K4ME3 PEPTIDE LEUKEMIA ALTERNATIVE SPLICING CHROMATIN REGULATOR DEVELOPMENTAL PROTEIN DIOXYGENASE IRON METAL-BINDING NUCLEUS OXIDOREDUCTASE PHOSPHOPROTEIN POLYMORPHISM TRANSCRIPTION TRANSCRIPTION REGULATION ZINC ZINC-FINGER CHROMOSOMAL PROTEIN DNA- BINDING NUCLEOSOME CORE
Ref.: HAEMATOPOIETIC MALIGNANCIES CAUSED BY DYSREGULATION OF A CHROMATIN-BINDING PHD FINGER. NATURE V. 459 847 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA ARG THR M3L GLN THR ALA ARG LYS B:1;
Valid;
none;
Kd = 0.75 uM
732.905 n/a O=C(N...
ZN A:1;
A:2;
A:3;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3GL6 1.9 Å EC: 1.14.11.- CRYSTAL STRUCTURE OF JARID1A-PHD3 COMPLEXED WITH H3(1-9) K4ME3 PEPTIDE HOMO SAPIENS PHD FINGERH3(1-9)K4ME3 PEPTIDE LEUKEMIA ALTERNATIVE SPLICING CHROMATIN REGULATOR DEVELOPMENTAL PROTEIN DIOXYGENASE IRON METAL-BINDING NUCLEUS OXIDOREDUCTASE PHOSPHOPROTEIN POLYMORPHISM TRANSCRIPTION TRANSCRIPTION REGULATION ZINC ZINC-FINGER CHROMOSOMAL PROTEIN DNA- BINDING NUCLEOSOME CORE
Ref.: HAEMATOPOIETIC MALIGNANCIES CAUSED BY DYSREGULATION OF A CHROMATIN-BINDING PHD FINGER. NATURE V. 459 847 2009
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 26 families.
1 3GL6 Kd = 0.75 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 18 families.
1 3GL6 Kd = 0.75 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 17 families.
1 3GL6 Kd = 0.75 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA ARG THR M3L GLN THR ALA ARG LYS; Similar ligands found: 74
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA ARG THR M3L GLN THR ALA ARG LYS 1 1
2 ALA ARG THR M3L GLN THR ALA 0.853933 1
3 ALA ARG THR M3L GLN THR ALA ARG LYS SER 0.853933 1
4 ALA ARG THR M3L GLN THR ALA 2MR LYS 0.853933 1
5 ALA ARG THR MLZ GLN THR ALA ARG LYS TYR 0.804348 0.885246
6 ALA ARG THR M3L GLN THR ALA ARG 0.734694 0.983871
7 ALA ARG THR M3L GLN THR ALA ALA LYS ALA 0.701923 0.983871
8 ALA ARG THR ALY GLN THR ALA 0.690722 0.852459
9 ALA ARG THR MLY GLN THR ALA 0.683673 0.967213
10 ALA ARG THR MLY GLN THR ALA ARG LYS TYR 0.683673 0.967213
11 ALA ARG THR LYS GLN THR ALA ARG LYS SER 0.67 0.819672
12 ALA ARG THR LYS GLN THR ALA ARG 0.647059 0.819672
13 ALA ARG THR LYS GLN THR ALA ARG LYS 0.647059 0.819672
14 ALA ARG THR M3L GLN THR ALA DA2 LYS 0.619835 1
15 ALA DA2 THR M3L GLN THR ALA ARG ALA 0.617391 1
16 ALA ARG THR MLY GLN THR ALA ARG LYS 0.616822 0.967213
17 ALA ARG THR MLY GLN 0.606061 0.935484
18 ALA ARG M3L SER 0.602151 0.919355
19 ALA ARG THR MLY GLN THR ALA ARG MLY SER 0.594059 0.95082
20 ALA ARG THR 4WQ GLN THR ALA ARG LYS SER 0.591837 0.854839
21 ALA ARG THR MLY GLN THR ALA ARG LYS SER 0.587629 0.758065
22 ALA GLN THR ALA ARG ALY SER THR 0.571429 0.83871
23 ALA ARG THR MLZ GLN THR ALA ARG LYS 0.5625 0.887097
24 GLN THR ALA ARG M3L SER THR GLY 0.538462 0.983871
25 ACE GLN THR ALA ARG KCR SER THR 0.537815 0.809524
26 THR ARG ARG GLU THR GLN LEU 0.528302 0.822581
27 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.527273 0.822581
28 GLN LEU ALA THR M3L ALA ALA ARG LYS SER 0.516393 1
29 ALA 2MR THR MLY GLN THR ALA ALA 0.512821 0.951613
30 ALA ALA LEU THR ARG ALA 0.504762 0.786885
31 PRO ALA THR ILE MET MET GLN ARG GLY ASN 0.504425 0.8125
32 LYS GLN THR ALA ARG M3L SER THR GLY 0.5 0.983871
33 ARG ARG ARG GLU THR GLN VAL 0.495146 0.774194
34 ALA ARG THR MLY GLN THR ALA ARG TYR 0.491935 0.867647
35 ALA ARG M3L SER THR GLY GLY ALY 0.491803 0.953125
36 GLU ALA GLN THR ARG LEU 0.491071 0.790323
37 ALA MET ARG VAL 0.479592 0.725806
38 PHE ALA GLY LEU ARG GLN ALA VAL THR GLN 0.465517 0.777778
39 ACE ALA ARG THR LYS GLN 0.462264 0.786885
40 THR ALA ARG M3L SER THR GLY GLY LYS ALA 0.460938 0.983871
41 ALA ARG THR GLU LEU TYR ARG SER LEU 0.456693 0.73913
42 LYS ALA ALA ARG ALY SER ALA PRO ALA 0.456311 0.790323
43 LEU GLY GLY ALA LYS GLN ARG GLY ASP VAL 0.45614 0.730159
44 THR ALA ARG M3L SER THR 0.455446 0.919355
45 GLY ARG PHE GLN VAL THR 0.455357 0.646154
46 LYS GLN THR SER VAL 0.453608 0.650794
47 LYS ALA ALA ARG M3L SER ALA 0.452174 0.951613
48 ILE LYS ARG SER MLZ LYS ASN SER LEU ALA 0.447619 0.83871
49 GLU THR VAL ARG PHE GLN SER ASP 0.44697 0.742424
50 ALA THR ARG ASN PHE SER GLY 0.439024 0.716418
51 ALA ASN SER ARG TRP ALY THR SER ILE ILE 0.43662 0.68
52 GLN ARG ALA THR LYS MET NH2 0.435897 0.854839
53 ILE LYS ARG SER LYS LYS ASN SER LEU ALA 0.435644 0.741935
54 THR M3L GLN 0.434343 0.868852
55 SAC ARG GLY THR GLN THR GLU 0.433333 0.765625
56 ASP PHE M3L THR ASP 0.42735 0.787879
57 ALA ILE ARG SER 0.427184 0.698413
58 GLU ARG THR ILE PRO ILE THR ARG GLU 0.426357 0.75
59 ALA ARG LYS SEP THR GLY GLY LYS 0.420635 0.764706
60 SER SER ARG LYS GLU TYR TYR ALA 0.418803 0.657143
61 ALA THR VAL ARG THR TYR SER CYS 0.416 0.685714
62 GLN ARG SER THR SEP THR 0.415254 0.735294
63 ALA PRO ALA LEU ARG VAL VAL LYS 0.412844 0.725806
64 ARG GLU ARG SER PRO THR ARG 0.412281 0.680556
65 THR ILE MET MET GLN ARG GLY 0.411765 0.8
66 ILE GLN GLN SER ILE GLU ARG ILE 0.411765 0.75
67 ALA ARG LYS ILE ASP ASN LEU ASP 0.41129 0.753846
68 ALA ARG M3L SER CYS GLY GLY LYS 08P 0.408759 0.869565
69 ALA ARG TPO LYS 0.407407 0.731343
70 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.405797 0.69863
71 PRO ALA ALA LYS ARG VAL LYS LEU ASP 0.403846 0.704918
72 LYS ARG ARG LYS SEP VAL 0.40367 0.720588
73 ALA ARG ALA ALA ALA ALA ALA ALA ALA 0.402062 0.66129
74 ALA LYS ALA SER GLN ALA ALA 0.401869 0.66129
Similar Binding Sites (Proteins are less than 50% similar to leader)
Feedback