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Receptor
PDB id Resolution Class Description Source Keywords
3GL6 1.9 Å EC: 1.14.11.- CRYSTAL STRUCTURE OF JARID1A-PHD3 COMPLEXED WITH H3(1-9) K4ME3 PEPTIDE HOMO SAPIENS PHD FINGERH3(1-9)K4ME3 PEPTIDE LEUKEMIA ALTERNATIVE SPLICING CHROMATIN REGULATOR DEVELOPMENTAL PROTEIN DIOXYGENASE IRON METAL-BINDING NUCLEUS OXIDOREDUCTASE PHOSPHOPROTEIN POLYMORPHISM TRANSCRIPTION TRANSCRIPTION REGULATION ZINC ZINC-FINGER CHROMOSOMAL PROTEIN DNA- BINDING NUCLEOSOME CORE
Ref.: HAEMATOPOIETIC MALIGNANCIES CAUSED BY DYSREGULATION OF A CHROMATIN-BINDING PHD FINGER. NATURE V. 459 847 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA ARG THR M3L GLN THR ALA ARG LYS B:1;
Valid;
none;
Kd = 0.75 uM
732.905 n/a O=C(N...
ZN A:1;
A:2;
A:3;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3GL6 1.9 Å EC: 1.14.11.- CRYSTAL STRUCTURE OF JARID1A-PHD3 COMPLEXED WITH H3(1-9) K4ME3 PEPTIDE HOMO SAPIENS PHD FINGERH3(1-9)K4ME3 PEPTIDE LEUKEMIA ALTERNATIVE SPLICING CHROMATIN REGULATOR DEVELOPMENTAL PROTEIN DIOXYGENASE IRON METAL-BINDING NUCLEUS OXIDOREDUCTASE PHOSPHOPROTEIN POLYMORPHISM TRANSCRIPTION TRANSCRIPTION REGULATION ZINC ZINC-FINGER CHROMOSOMAL PROTEIN DNA- BINDING NUCLEOSOME CORE
Ref.: HAEMATOPOIETIC MALIGNANCIES CAUSED BY DYSREGULATION OF A CHROMATIN-BINDING PHD FINGER. NATURE V. 459 847 2009
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 31 families.
1 3GL6 Kd = 0.75 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 19 families.
1 3GL6 Kd = 0.75 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 17 families.
1 3GL6 Kd = 0.75 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA ARG THR M3L GLN THR ALA ARG LYS; Similar ligands found: 80
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA ARG THR M3L GLN THR ALA ARG LYS 1 1
2 ALA ARG THR M3L GLN THR ALA ARG LYS SER 1 1
3 ALA ARG THR M3L GLN THR ALA 0.852273 1
4 ALA ARG THR M3L GLN THR ALA 2MR LYS 0.852273 1
5 ALA ARG THR MLZ GLN THR ALA ARG LYS TYR 0.804348 0.885246
6 ALA ARG THR MLY GLN THR ALA ARG LYS 0.804348 0.95082
7 ALA ARG THR M3L GLN THR ALA ARG 0.72449 0.983871
8 ALA ARG THR ALY GLN THR ALA 0.697917 0.852459
9 ALA ARG THR MLY GLN THR ALA ARG LYS TYR 0.683673 0.967213
10 ALA ARG THR MLY GLN THR ALA 0.683673 0.967213
11 ALA ARG THR M3L GLN THR ALA ALA LYS ALA 0.679245 0.983871
12 ARG ARG ARG GLU THR GLN VAL 0.635417 0.806452
13 ALA ARG THR LYS GLN THR ALA ARG LYS 0.634615 0.819672
14 ALA DA2 THR M3L GLN THR ALA ARG ALA 0.614035 1
15 ALA ARG THR LYS GLN THR ALA ARG 0.612245 0.803279
16 ALA ARG THR MLZ GLN THR ALA ARG LYS 0.611111 0.901639
17 ALA ARG M3L SER 0.608696 0.919355
18 ALA ARG THR M3L GLN THR ALA DA2 LYS 0.601626 1
19 ALA ARG THR MLY GLN 0.6 0.935484
20 ALA ARG THR 4WQ GLN THR ALA ARG LYS SER 0.597938 0.854839
21 ALA ARG THR MLY GLN THR ALA ARG MLY SER 0.594059 0.95082
22 ALA ARG THR MLY GLN THR ALA ARG LYS SER 0.587629 0.758065
23 ALA GLN THR ALA ARG ALY SER THR 0.576577 0.83871
24 GLN THR ALA ARG M3L SER 0.572727 0.983871
25 THR ARG ARG GLU THR GLN LEU 0.557692 0.822581
26 ALA ARG 9AT 0.552941 0.754098
27 GLN THR ALA ARG M3L SER THR GLY 0.538462 0.983871
28 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.536364 0.822581
29 ALA ARG THR ALA ALA THR ALA ARG LYS SER 0.535354 0.770492
30 LYS GLN THR ALA ARG M3L SER THR GLY 0.522523 0.983871
31 GLY ARG PHE GLN VAL THR 0.522124 0.707692
32 GLN LEU ALA THR M3L ALA ALA ARG LYS SER 0.517857 0.983607
33 ASN ARG LEU LEU LEU THR GLY 0.515152 0.790323
34 PRO ALA THR ILE MET MET GLN ARG GLY ASN 0.513514 0.8125
35 ALA ALA LEU THR ARG ALA 0.509615 0.786885
36 GLU ALA GLN THR ARG LEU 0.495575 0.790323
37 ALA MET ARG VAL 0.494845 0.725806
38 ALA ARG THR MLY GLN THR ALA ARG TYR 0.491935 0.867647
39 ALA ARG M3L SER THR GLY GLY ALY 0.491803 0.953125
40 ACE GLN THR ALA ARG PRK SER THR 0.487179 0.78125
41 ALA 2MR THR MLY GLN THR ALA ALA 0.486239 0.967213
42 THR ALA ARG M3L SER THR 0.474747 0.919355
43 ACE GLU ALA GLN THR ARG LEU 0.473684 0.806452
44 ACE GLN THR ALA ARG KCR SER THR 0.471074 0.793651
45 PHE ALA GLY LEU ARG GLN ALA VAL THR GLN 0.470085 0.777778
46 LYS ALA ALA ARG M3L SER ALA 0.46087 0.951613
47 PRO PRO LYS LYS LYS ARG LYS VAL 0.46 0.704918
48 ACE GLN THR ALA ARG BTK SER THR 0.457627 0.809524
49 ILE LYS ARG SER MLZ LYS ASN SER LEU ALA 0.457143 0.83871
50 LEU GLY GLY ALA LYS GLN ARG GLY ASP VAL 0.456897 0.730159
51 ALA ARG THR GLU LEU TYR ARG SER LEU 0.453125 0.73913
52 SAC ARG GLY THR GLN THR GLU 0.452991 0.765625
53 GLU THR VAL ARG PHE GLN SER ASP 0.446154 0.727273
54 ACE ALA ARG THR LYS GLN 0.444444 0.786885
55 THR M3L GLN 0.443299 0.868852
56 ALA ILE ARG SER 0.441176 0.698413
57 THR ILE MET MET GLN ARG GLY 0.439655 0.8
58 ILE LYS ARG SER LYS LYS ASN SER LEU ALA 0.436893 0.741935
59 ALA THR ARG ASN PHE SER GLY 0.430894 0.716418
60 GLN ARG ALA THR LYS MET NH2 0.429752 0.854839
61 LYS GLN THR SER VAL 0.428571 0.650794
62 ILE GLN GLN SER ILE GLU ARG ILE 0.42735 0.75
63 THR ALA ARG M3L SER THR GLY GLY LYS ALA 0.424779 0.870968
64 ALA ARG LYS SEP THR GLY GLY LYS 0.421875 0.764706
65 ARG GLU ARG SER PRO THR ARG 0.421053 0.680556
66 PRO ALA ALA LYS ARG VAL LYS LEU ASP 0.419048 0.704918
67 GLU ARG THR ILE PRO ILE THR ARG GLU 0.417323 0.746479
68 SER SER ARG LYS GLU TYR TYR ALA 0.416667 0.657143
69 ALA ASN SER ARG TRP ALY THR SER ILE ILE 0.416107 0.706667
70 ALA GLN ASP ILE TYR ARG ALA SER TYR 0.414286 0.680556
71 ALA ARG LYS ILE ASP ASN LEU ASP 0.412698 0.753846
72 ALA ARG ALA ALA ALA ALA ALA ALA ALA 0.412371 0.66129
73 ARG ARG ALA THR LYS MET NH2 0.411765 0.854839
74 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.410959 0.68
75 ALA ASN SER ARG TRP GLN THR SER ILE ILE 0.410959 0.644737
76 ASP PHE M3L THR ASP 0.40678 0.80303
77 ALA THR VAL ARG THR TYR SER CYS 0.404762 0.685714
78 ALA ARG M3L SER CYS GLY GLY LYS 08P 0.402878 0.869565
79 LYS ARG ARG LYS SEP VAL 0.401786 0.720588
80 ALA PRO ALA LEU ARG VAL VAL LYS 0.401786 0.725806
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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