Receptor
PDB id Resolution Class Description Source Keywords
3FU3 2 Å EC: 3.3.2.6 LEUKOTRIENE A4 HYDROLASE IN COMPLEX WITH FRAGMENT 4-(2- AMINO-1,3-THIAZOL-4-YL)PHENOL HOMO SAPIENS LEUKOTRIENE A4 HYDROLASE LTA4H FRAGMENT CRYSTALLOGRAPHY FRAGMENTS OF LIFE FOL ALTERNATIVE SPLICING CYTOPLASM HYDROLASE LEUKOTRIENE BIOSYNTHESIS METAL-BINDING METALLOPROTEASE MULTIFUNCTIONAL ENZYME POLYMORPHISM PROTEASE ZINC
Ref.: DISCOVERY OF LEUKOTRIENE A4 HYDROLASE INHIBITORS USING METABOLOMICS BIASED FRAGMENT CRYSTALLOGRAPHY. J.MED.CHEM. V. 52 4694 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
92G A:710;
A:720;
 Valid;
Valid;
 none;
none;
 ic50 = 1443 uM
192.238 C9 H8 N2 O S c1cc(...
ACT A:801;
A:802;
 Invalid;
Invalid;
 none;
none;
 submit data
59.044 C2 H3 O2 CC(=O...
IMD A:803;
A:804;
 Invalid;
Invalid;
 none;
none;
 submit data
69.085 C3 H5 N2 c1c[n...
YB A:702;
 Invalid;
 none;
 submit data
173.04 Yb [Yb+3...
ZN A:701;
 Part of Protein;
 none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2VJ8 1.8 Å EC: 3.3.2.6 COMPLEX OF HUMAN LEUKOTRIENE A4 HYDROLASE WITH A HYDROXAMIC INHIBITOR HOMO SAPIENS HYDROXAMIC ACID LEUKOTRIENE HYDROLASE ZINC PROTEASE HYDRMETALLOPROTEASE
Ref.: CRYSTAL STRUCTURES OF LEUKOTRIENE A4 HYDROLASE IN C WITH CAPTOPRIL AND TWO COMPETITIVE TIGHT-BINDING IN FASEB J. V. 16 1648 2002
Members (48)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3FTW - 11X C12 H12 N2 c1ccc(cc1)....
2 3FUK ic50 = 966 uM 58Z C16 H20 N2 O3 c1cc2c(cc[....
3 3FU6 ic50 = 106 uM 80G C11 H11 N S c1cc(sc1)c....
4 6END ic50 = 0.133 uM BGK C13 H8 N2 O2 S c1cc2c(nc1....
5 3FUI ic50 = 0.157 uM 812 C18 H22 N2 O c1ccc(cc1)....
6 3FU5 ic50 = 75.2 uM 492 C9 H9 N S2 c1cc(sc1)c....
7 2R59 Ki = 6.5 nM PH0 C27 H31 N2 O5 P c1ccc(cc1)....
8 5N3W ic50 = 0.5 uM 8KW C15 H16 O3 COc1cc(cc(....
9 3CHP ic50 = 5400 nM 4BO C17 H18 N2 O4 c1ccc(cc1)....
10 4L2L Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
11 1HS6 - BES C16 H24 N2 O4 CC(C)C[C@@....
12 6ENB - PRO GLY PRO n/a n/a
13 3B7T - ARG ALA ARG n/a n/a
14 3B7R Ki = 20 nM BIR C21 H27 N2 O5 P C[C@@H](C(....
15 3FUN ic50 = 0.189 uM 798 C22 H21 N O2 S c1cc(ccc1c....
16 3FTX - BES C16 H24 N2 O4 CC(C)C[C@@....
17 5NI4 - DJ3 C20 H30 O3 CCCCC/C=CC....
18 3CHR ic50 = 61 nM 4BS C17 H20 N2 O2 c1ccc(cc1)....
19 3B7S - ARG SER ARG n/a n/a
20 2VJ8 Ki = 0.002 uM HA2 C22 H28 N2 O5 c1ccc(cc1)....
21 3FUH - BES C16 H24 N2 O4 CC(C)C[C@@....
22 5AEN ic50 = 0.06 uM DP8 C16 H19 N O2 CN(C)CCOc1....
23 4MS6 - 28T C13 H20 N2 O4 C1C[C@H](N....
24 3FUE ic50 = 1510 uM 11S C8 H6 Cl N c1cc2c(cc[....
25 3FH8 ic50 = 180 nM 27P C19 H23 N O c1ccc(cc1)....
26 5BPP ic50 = 15.86 uM A4Z C12 H17 N O3 CCCCOc1ccc....
27 3FTZ - 848 C12 H12 N2 O c1ccc(c(c1....
28 5NI6 - DJ3 C20 H30 O3 CCCCC/C=CC....
29 3FTV ic50 = 1667 uM 11X C12 H12 N2 c1ccc(cc1)....
30 3CHQ ic50 = 20 nM 4BQ C18 H20 N2 O4 c1ccc(cc1)....
31 3FUL ic50 = 199 uM 52D C18 H20 N2 O2 c1cc(ccc1C....
32 3FTS ic50 = 212 uM STL C14 H12 O3 c1cc(ccc1C....
33 3FHE - 28P C20 H25 N O3 C[N@@](CCC....
34 6ENC ic50 = 0.019 uM BGW C20 H20 N2 O3 S c1ccc2c(c1....
35 3FUM ic50 = 170 uM 80A C18 H22 N2 O2 c1cc(ccc1[....
36 3B7U - KEL C14 H18 N2 O5 C[C@@H](C(....
37 3FTY ic50 = 619 uM 3IP C12 H12 N2 O c1ccc(cc1)....
38 3FTU ic50 = 247 uM RE2 C14 H14 O3 c1cc(ccc1C....
39 3FH7 Kd = 25 nM 25P C21 H23 Cl N O4 c1cc(ccc1O....
40 3FUJ ic50 = 234 uM 00G C14 H14 N2 O c1ccn(c1)C....
41 3FU0 ic50 = 5308 uM 22F C12 H8 F N O c1cc(ccc1C....
42 3FH5 ic50 = 87 nM 24P C18 H21 N O c1ccc(cc1)....
43 3CHO ic50 = 280 nM 4BG C15 H16 N2 O2 c1ccc(cc1)....
44 3FUD ic50 > 2000 uM 692 C12 H13 N S CNCc1ccccc....
45 3FU3 ic50 = 1443 uM 92G C9 H8 N2 O S c1cc(ccc1c....
46 4MKT Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
47 5NI2 - DJ3 C20 H30 O3 CCCCC/C=CC....
48 1GW6 - BES C16 H24 N2 O4 CC(C)C[C@@....
70% Homology Family (49)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 3FTW - 11X C12 H12 N2 c1ccc(cc1)....
2 3FUK ic50 = 966 uM 58Z C16 H20 N2 O3 c1cc2c(cc[....
3 3FU6 ic50 = 106 uM 80G C11 H11 N S c1cc(sc1)c....
4 6END ic50 = 0.133 uM BGK C13 H8 N2 O2 S c1cc2c(nc1....
5 3FUI ic50 = 0.157 uM 812 C18 H22 N2 O c1ccc(cc1)....
6 3FU5 ic50 = 75.2 uM 492 C9 H9 N S2 c1cc(sc1)c....
7 2R59 Ki = 6.5 nM PH0 C27 H31 N2 O5 P c1ccc(cc1)....
8 5N3W ic50 = 0.5 uM 8KW C15 H16 O3 COc1cc(cc(....
9 3CHP ic50 = 5400 nM 4BO C17 H18 N2 O4 c1ccc(cc1)....
10 4L2L Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
11 1HS6 - BES C16 H24 N2 O4 CC(C)C[C@@....
12 6ENB - PRO GLY PRO n/a n/a
13 3B7T - ARG ALA ARG n/a n/a
14 3B7R Ki = 20 nM BIR C21 H27 N2 O5 P C[C@@H](C(....
15 3FUN ic50 = 0.189 uM 798 C22 H21 N O2 S c1cc(ccc1c....
16 3FTX - BES C16 H24 N2 O4 CC(C)C[C@@....
17 5NI4 - DJ3 C20 H30 O3 CCCCC/C=CC....
18 3CHR ic50 = 61 nM 4BS C17 H20 N2 O2 c1ccc(cc1)....
19 3B7S - ARG SER ARG n/a n/a
20 2VJ8 Ki = 0.002 uM HA2 C22 H28 N2 O5 c1ccc(cc1)....
21 3FUH - BES C16 H24 N2 O4 CC(C)C[C@@....
22 5AEN ic50 = 0.06 uM DP8 C16 H19 N O2 CN(C)CCOc1....
23 4MS6 - 28T C13 H20 N2 O4 C1C[C@H](N....
24 3FUE ic50 = 1510 uM 11S C8 H6 Cl N c1cc2c(cc[....
25 3FH8 ic50 = 180 nM 27P C19 H23 N O c1ccc(cc1)....
26 5BPP ic50 = 15.86 uM A4Z C12 H17 N O3 CCCCOc1ccc....
27 3FTZ - 848 C12 H12 N2 O c1ccc(c(c1....
28 5NI6 - DJ3 C20 H30 O3 CCCCC/C=CC....
29 3FTV ic50 = 1667 uM 11X C12 H12 N2 c1ccc(cc1)....
30 3CHQ ic50 = 20 nM 4BQ C18 H20 N2 O4 c1ccc(cc1)....
31 3FUL ic50 = 199 uM 52D C18 H20 N2 O2 c1cc(ccc1C....
32 3FTS ic50 = 212 uM STL C14 H12 O3 c1cc(ccc1C....
33 3FHE - 28P C20 H25 N O3 C[N@@](CCC....
34 6ENC ic50 = 0.019 uM BGW C20 H20 N2 O3 S c1ccc2c(c1....
35 3FUM ic50 = 170 uM 80A C18 H22 N2 O2 c1cc(ccc1[....
36 3B7U - KEL C14 H18 N2 O5 C[C@@H](C(....
37 3FTY ic50 = 619 uM 3IP C12 H12 N2 O c1ccc(cc1)....
38 3FTU ic50 = 247 uM RE2 C14 H14 O3 c1cc(ccc1C....
39 3FH7 Kd = 25 nM 25P C21 H23 Cl N O4 c1cc(ccc1O....
40 3FUJ ic50 = 234 uM 00G C14 H14 N2 O c1ccn(c1)C....
41 3FU0 ic50 = 5308 uM 22F C12 H8 F N O c1cc(ccc1C....
42 3FH5 ic50 = 87 nM 24P C18 H21 N O c1ccc(cc1)....
43 3CHO ic50 = 280 nM 4BG C15 H16 N2 O2 c1ccc(cc1)....
44 3FUD ic50 > 2000 uM 692 C12 H13 N S CNCc1ccccc....
45 3FU3 ic50 = 1443 uM 92G C9 H8 N2 O S c1cc(ccc1c....
46 4MKT Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
47 5NI2 - DJ3 C20 H30 O3 CCCCC/C=CC....
48 1GW6 - BES C16 H24 N2 O4 CC(C)C[C@@....
49 4GAA - BES C16 H24 N2 O4 CC(C)C[C@@....
50% Homology Family (50)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3FTW - 11X C12 H12 N2 c1ccc(cc1)....
2 3FUK ic50 = 966 uM 58Z C16 H20 N2 O3 c1cc2c(cc[....
3 3FU6 ic50 = 106 uM 80G C11 H11 N S c1cc(sc1)c....
4 6END ic50 = 0.133 uM BGK C13 H8 N2 O2 S c1cc2c(nc1....
5 3FUI ic50 = 0.157 uM 812 C18 H22 N2 O c1ccc(cc1)....
6 3FU5 ic50 = 75.2 uM 492 C9 H9 N S2 c1cc(sc1)c....
7 2R59 Ki = 6.5 nM PH0 C27 H31 N2 O5 P c1ccc(cc1)....
8 5N3W ic50 = 0.5 uM 8KW C15 H16 O3 COc1cc(cc(....
9 3CHP ic50 = 5400 nM 4BO C17 H18 N2 O4 c1ccc(cc1)....
10 4L2L Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
11 1HS6 - BES C16 H24 N2 O4 CC(C)C[C@@....
12 6ENB - PRO GLY PRO n/a n/a
13 3B7T - ARG ALA ARG n/a n/a
14 3B7R Ki = 20 nM BIR C21 H27 N2 O5 P C[C@@H](C(....
15 3FUN ic50 = 0.189 uM 798 C22 H21 N O2 S c1cc(ccc1c....
16 3FTX - BES C16 H24 N2 O4 CC(C)C[C@@....
17 5NI4 - DJ3 C20 H30 O3 CCCCC/C=CC....
18 3CHR ic50 = 61 nM 4BS C17 H20 N2 O2 c1ccc(cc1)....
19 3B7S - ARG SER ARG n/a n/a
20 2VJ8 Ki = 0.002 uM HA2 C22 H28 N2 O5 c1ccc(cc1)....
21 3FUH - BES C16 H24 N2 O4 CC(C)C[C@@....
22 5AEN ic50 = 0.06 uM DP8 C16 H19 N O2 CN(C)CCOc1....
23 4MS6 - 28T C13 H20 N2 O4 C1C[C@H](N....
24 3FUE ic50 = 1510 uM 11S C8 H6 Cl N c1cc2c(cc[....
25 3FH8 ic50 = 180 nM 27P C19 H23 N O c1ccc(cc1)....
26 5BPP ic50 = 15.86 uM A4Z C12 H17 N O3 CCCCOc1ccc....
27 3FTZ - 848 C12 H12 N2 O c1ccc(c(c1....
28 5NI6 - DJ3 C20 H30 O3 CCCCC/C=CC....
29 3FTV ic50 = 1667 uM 11X C12 H12 N2 c1ccc(cc1)....
30 3CHQ ic50 = 20 nM 4BQ C18 H20 N2 O4 c1ccc(cc1)....
31 3FUL ic50 = 199 uM 52D C18 H20 N2 O2 c1cc(ccc1C....
32 3FTS ic50 = 212 uM STL C14 H12 O3 c1cc(ccc1C....
33 3FHE - 28P C20 H25 N O3 C[N@@](CCC....
34 6ENC ic50 = 0.019 uM BGW C20 H20 N2 O3 S c1ccc2c(c1....
35 3FUM ic50 = 170 uM 80A C18 H22 N2 O2 c1cc(ccc1[....
36 3B7U - KEL C14 H18 N2 O5 C[C@@H](C(....
37 3FTY ic50 = 619 uM 3IP C12 H12 N2 O c1ccc(cc1)....
38 3FTU ic50 = 247 uM RE2 C14 H14 O3 c1cc(ccc1C....
39 3FH7 Kd = 25 nM 25P C21 H23 Cl N O4 c1cc(ccc1O....
40 3FUJ ic50 = 234 uM 00G C14 H14 N2 O c1ccn(c1)C....
41 3FU0 ic50 = 5308 uM 22F C12 H8 F N O c1cc(ccc1C....
42 3FH5 ic50 = 87 nM 24P C18 H21 N O c1ccc(cc1)....
43 3CHO ic50 = 280 nM 4BG C15 H16 N2 O2 c1ccc(cc1)....
44 3FUD ic50 > 2000 uM 692 C12 H13 N S CNCc1ccccc....
45 3FU3 ic50 = 1443 uM 92G C9 H8 N2 O S c1cc(ccc1c....
46 4MKT Ki = 2.3 uM 1V6 C16 H14 N2 S c1ccc(cc1)....
47 5NI2 - DJ3 C20 H30 O3 CCCCC/C=CC....
48 1GW6 - BES C16 H24 N2 O4 CC(C)C[C@@....
49 4GAA - BES C16 H24 N2 O4 CC(C)C[C@@....
50 2XQ0 - BES C16 H24 N2 O4 CC(C)C[C@@....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 92G; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 92G 1 1
2 1V6 0.48 0.756757
3 JUT 0.456522 0.682927
Similar Ligands (3D)
Ligand no: 1; Ligand: 92G; Similar ligands found: 849
No: Ligand Similarity coefficient
1 6ZX 0.9767
2 HX4 0.9720
3 MSR 0.9709
4 A5E 0.9695
5 IWT 0.9666
6 GVY 0.9659
7 CPZ 0.9653
8 36Y 0.9651
9 6SD 0.9646
10 PH3 0.9630
11 7VP 0.9627
12 FZM 0.9616
13 SNU 0.9614
14 0NX 0.9605
15 BP7 0.9602
16 P81 0.9590
17 C53 0.9587
18 XDK 0.9582
19 1A7 0.9579
20 50C 0.9578
21 YZM 0.9571
22 JAH 0.9567
23 GT4 0.9549
24 HC4 0.9544
25 5O6 0.9536
26 X48 0.9533
27 RA7 0.9532
28 80G 0.9529
29 F4K 0.9527
30 5LA 0.9523
31 C1M 0.9519
32 SWX 0.9513
33 BNL 0.9512
34 2QC 0.9506
35 1Z6 0.9501
36 HNH 0.9499
37 TZF 0.9493
38 ENO 0.9492
39 PPY 0.9492
40 E3X 0.9485
41 L03 0.9478
42 1L5 0.9474
43 L22 0.9462
44 XCG 0.9456
45 EN1 0.9446
46 N9J 0.9445
47 F4E 0.9445
48 KTJ 0.9442
49 D3G 0.9429
50 TT4 0.9425
51 4BY 0.9424
52 4HB 0.9413
53 TMG 0.9412
54 4LV 0.9412
55 J9N 0.9411
56 28A 0.9409
57 EQW 0.9408
58 6FB 0.9407
59 ESX 0.9405
60 M6H 0.9392
61 0BP 0.9386
62 4LW 0.9384
63 BPY 0.9383
64 K80 0.9377
65 GB5 0.9374
66 6KT 0.9373
67 HNL 0.9373
68 CK2 0.9373
69 LVD 0.9373
70 XIZ 0.9369
71 36M 0.9365
72 HNK 0.9363
73 TYC 0.9362
74 IPO 0.9362
75 C82 0.9361
76 PO6 0.9359
77 FMQ 0.9358
78 UNJ 0.9356
79 AWE 0.9355
80 PIM 0.9344
81 ODK 0.9338
82 363 0.9336
83 BZ2 0.9335
84 A5H 0.9329
85 CH9 0.9327
86 HXY 0.9325
87 OTR 0.9324
88 4V2 0.9322
89 4BX 0.9318
90 Y3L 0.9315
91 S0D 0.9312
92 TYR 0.9311
93 BZE 0.9305
94 6TZ 0.9304
95 4BF 0.9303
96 0K7 0.9302
97 3ZB 0.9297
98 TCA 0.9296
99 X0U 0.9294
100 2PK 0.9293
101 3VS 0.9293
102 3YP 0.9290
103 SOJ 0.9289
104 H4E 0.9289
105 I3E 0.9289
106 QIV 0.9286
107 HCI 0.9286
108 795 0.9286
109 DPN 0.9285
110 DTY 0.9284
111 G14 0.9280
112 ZZA 0.9279
113 PJW 0.9279
114 AMR 0.9274
115 PFF 0.9267
116 KMY 0.9263
117 4XF 0.9262
118 PIY 0.9261
119 FHC 0.9261
120 2PV 0.9261
121 GO2 0.9259
122 61M 0.9258
123 5OO 0.9258
124 ALE 0.9251
125 54E 0.9250
126 CK1 0.9249
127 PUE 0.9246
128 ERZ 0.9246
129 4FF 0.9243
130 9FG 0.9241
131 HPP 0.9240
132 ICB 0.9240
133 9FH 0.9240
134 M3H 0.9239
135 PCS 0.9237
136 M3E 0.9236
137 J6W 0.9236
138 1KN 0.9232
139 LJ3 0.9230
140 VC3 0.9230
141 LR8 0.9228
142 TB8 0.9228
143 B1J 0.9227
144 R20 0.9226
145 AOT 0.9224
146 MPV 0.9223
147 TRP 0.9222
148 4I8 0.9220
149 EYJ 0.9218
150 NFA 0.9215
151 S0W 0.9215
152 4WL 0.9214
153 3VQ 0.9211
154 P7Y 0.9210
155 DHC 0.9210
156 833 0.9210
157 PQM 0.9209
158 EYV 0.9207
159 TYL 0.9206
160 HQJ 0.9205
161 6P3 0.9202
162 M45 0.9202
163 PPT 0.9200
164 R2P 0.9200
165 8D6 0.9199
166 BQ2 0.9198
167 KDG 0.9195
168 TIH 0.9191
169 2P3 0.9190
170 PHI 0.9189
171 1F1 0.9184
172 6FZ 0.9182
173 PRL 0.9181
174 Z70 0.9181
175 KLE 0.9176
176 PQS 0.9174
177 GB4 0.9172
178 TJM 0.9170
179 CFA 0.9169
180 QME 0.9167
181 OQC 0.9165
182 492 0.9164
183 TOH 0.9163
184 BVS 0.9162
185 JAW 0.9161
186 A29 0.9159
187 2ZM 0.9158
188 6NI 0.9156
189 L5V 0.9155
190 7MW 0.9153
191 GZ2 0.9152
192 4VY 0.9151
193 JMG 0.9150
194 2F6 0.9150
195 6N4 0.9149
196 S1D 0.9148
197 JSX 0.9147
198 SQ4 0.9145
199 NCT 0.9145
200 6NT 0.9143
201 L13 0.9143
202 FCD 0.9143
203 VBC 0.9143
204 1XS 0.9141
205 HIC 0.9141
206 SV4 0.9139
207 4ZA 0.9138
208 GVG 0.9138
209 X6W 0.9138
210 AVA 0.9137
211 0HN 0.9137
212 FF2 0.9135
213 JRB 0.9135
214 HFA 0.9134
215 DIR 0.9131
216 2HC 0.9130
217 5H6 0.9128
218 94W 0.9128
219 F90 0.9124
220 4FP 0.9123
221 1SF 0.9123
222 LZ5 0.9123
223 4P5 0.9121
224 ANN 0.9118
225 LQ2 0.9118
226 PHE 0.9118
227 52C 0.9116
228 MMS 0.9115
229 3A9 0.9115
230 2FX 0.9114
231 P80 0.9114
232 FTV 0.9114
233 KYN 0.9113
234 3NY 0.9113
235 RQD 0.9111
236 3VW 0.9109
237 T2D 0.9106
238 56D 0.9105
239 DDU 0.9105
240 THU 0.9104
241 SQ7 0.9101
242 KLS 0.9101
243 JCZ 0.9100
244 9FL 0.9090
245 HL4 0.9090
246 LNR 0.9090
247 TYE 0.9088
248 1VK 0.9088
249 LL1 0.9087
250 J9Q 0.9086
251 QBS 0.9086
252 MUK 0.9084
253 A6Z 0.9081
254 ODO 0.9079
255 DAH 0.9079
256 2D2 0.9079
257 0HO 0.9078
258 GNW 0.9077
259 D2G 0.9074
260 7MX 0.9074
261 28B 0.9073
262 9R5 0.9073
263 ESI 0.9072
264 9ZE 0.9072
265 BVA 0.9072
266 HHH 0.9072
267 5FL 0.9072
268 HDH 0.9071
269 ESP 0.9071
270 DUR 0.9070
271 BZJ 0.9070
272 A7Q 0.9069
273 FYR 0.9067
274 EGR 0.9066
275 428 0.9066
276 MXD 0.9065
277 Y4L 0.9065
278 JF6 0.9065
279 MPK 0.9063
280 XI7 0.9063
281 27K 0.9062
282 D1Y 0.9061
283 W29 0.9060
284 RUY 0.9060
285 97T 0.9060
286 MP5 0.9059
287 6HO 0.9058
288 0LO 0.9058
289 HWD 0.9057
290 AKG 0.9056
291 EAT 0.9055
292 A7H 0.9054
293 ZEC 0.9053
294 9UL 0.9051
295 X11 0.9051
296 EVF 0.9051
297 HIS 0.9050
298 0SY 0.9050
299 15N 0.9049
300 5F8 0.9047
301 IYR 0.9046
302 URO 0.9046
303 LSQ 0.9045
304 A4N 0.9044
305 BGU 0.9044
306 PNZ 0.9042
307 PBN 0.9042
308 BRH 0.9041
309 E0O 0.9041
310 46P 0.9037
311 NFM 0.9036
312 LO1 0.9035
313 3R4 0.9035
314 4JQ 0.9034
315 N3W 0.9033
316 WVV 0.9030
317 BP3 0.9030
318 36E 0.9029
319 BBY 0.9029
320 C0H 0.9029
321 5TT 0.9029
322 78Y 0.9028
323 S0E 0.9025
324 QUS 0.9019
325 2JX 0.9019
326 GF4 0.9018
327 8XL 0.9018
328 RNO 0.9017
329 5VU 0.9015
330 M1T 0.9015
331 K7H 0.9014
332 HHI 0.9013
333 L15 0.9013
334 FHV 0.9012
335 JDN 0.9010
336 GJP 0.9010
337 OHJ 0.9009
338 CWJ 0.9009
339 ABI 0.9007
340 D8Q 0.9007
341 4RU 0.9006
342 7OD 0.9005
343 DE5 0.9002
344 4BL 0.9001
345 KTW 0.9001
346 YPN 0.9000
347 OOG 0.8999
348 PRA 0.8999
349 0UL 0.8999
350 A4T 0.8999
351 EQA 0.8998
352 0OY 0.8998
353 BPW 0.8998
354 5VL 0.8995
355 MS9 0.8994
356 68A 0.8994
357 7R4 0.8993
358 1WC 0.8992
359 DHY 0.8992
360 I2E 0.8991
361 1M2 0.8990
362 N2Z 0.8989
363 0JD 0.8989
364 EUE 0.8988
365 A9B 0.8986
366 XIY 0.8984
367 ISZ 0.8981
368 TZM 0.8977
369 PLP 0.8977
370 AUV 0.8976
371 SNO 0.8976
372 HNT 0.8975
373 DHI 0.8974
374 SQV 0.8974
375 BHO 0.8971
376 2FY 0.8970
377 CFI 0.8970
378 2BG 0.8969
379 IS2 0.8969
380 B40 0.8969
381 HX8 0.8969
382 OGA 0.8968
383 4FA 0.8967
384 4AU 0.8966
385 JB8 0.8966
386 5AD 0.8965
387 AAN 0.8965
388 AJG 0.8962
389 HRM 0.8960
390 HJH 0.8960
391 7O4 0.8960
392 NYL 0.8960
393 MMJ 0.8960
394 OLU 0.8958
395 CXH 0.8957
396 JA5 0.8956
397 K48 0.8956
398 SHI 0.8955
399 TGX 0.8954
400 Q06 0.8953
401 FDR 0.8953
402 GCO 0.8952
403 TI7 0.8948
404 4YO 0.8948
405 5NI 0.8947
406 ZRK 0.8946
407 S2P 0.8946
408 JGB 0.8946
409 AVX 0.8945
410 3C5 0.8945
411 A51 0.8942
412 JPQ 0.8939
413 LFQ 0.8938
414 YRL 0.8938
415 4G2 0.8937
416 8NB 0.8937
417 V1T 0.8936
418 0FR 0.8935
419 4FE 0.8932
420 URI 0.8932
421 NIZ 0.8931
422 MJ5 0.8931
423 DC5 0.8929
424 1ZC 0.8928
425 AHN 0.8928
426 NE2 0.8927
427 N2I 0.8926
428 NK5 0.8925
429 B2T 0.8924
430 5F5 0.8924
431 4Z3 0.8924
432 E7S 0.8921
433 5GT 0.8921
434 173 0.8921
435 IAC 0.8920
436 AEG 0.8919
437 26P 0.8918
438 FBC 0.8917
439 Q4G 0.8917
440 J1K 0.8913
441 GZQ 0.8912
442 IOP 0.8912
443 AN3 0.8911
444 SN4 0.8910
445 5E5 0.8910
446 ARG 0.8909
447 JBZ 0.8908
448 R9J 0.8907
449 3VX 0.8907
450 E4P 0.8906
451 268 0.8905
452 A7N 0.8904
453 S2G 0.8904
454 1XA 0.8903
455 GWM 0.8902
456 U4J 0.8901
457 KF5 0.8899
458 2HG 0.8897
459 CC5 0.8897
460 OA1 0.8895
461 2JM 0.8894
462 6H2 0.8894
463 HH6 0.8893
464 ONR 0.8892
465 60L 0.8891
466 N91 0.8890
467 K34 0.8890
468 F06 0.8889
469 S0F 0.8888
470 PBA 0.8887
471 4ZD 0.8887
472 4NB 0.8886
473 6HX 0.8886
474 ES2 0.8885
475 M1Z 0.8882
476 2K8 0.8882
477 DCZ 0.8880
478 KWB 0.8880
479 SOR 0.8879
480 HHS 0.8878
481 2B4 0.8877
482 M5H 0.8876
483 15E 0.8876
484 4CF 0.8875
485 CS2 0.8874
486 P9E 0.8871
487 HNM 0.8870
488 657 0.8868
489 613 0.8866
490 RSV 0.8862
491 3QO 0.8861
492 6MW 0.8860
493 YE6 0.8859
494 GOE 0.8859
495 IOS 0.8858
496 8YH 0.8857
497 ZME 0.8857
498 9NB 0.8857
499 258 0.8855
500 FWD 0.8855
501 5GV 0.8855
502 X6P 0.8852
503 N1E 0.8852
504 N8Z 0.8850
505 NAG 0.8849
506 6L6 0.8849
507 F16 0.8847
508 3D8 0.8847
509 BSA 0.8846
510 1PS 0.8845
511 MAJ 0.8845
512 650 0.8844
513 JF8 0.8843
514 FPL 0.8843
515 2BX 0.8842
516 AMH 0.8842
517 PBZ 0.8842
518 L99 0.8841
519 FBM 0.8840
520 8OB 0.8838
521 FC2 0.8837
522 TIA 0.8836
523 AU8 0.8835
524 4HP 0.8834
525 5C1 0.8834
526 H4B 0.8834
527 K7M 0.8833
528 A9P 0.8832
529 LDP 0.8832
530 VXX 0.8832
531 MR6 0.8831
532 EXD 0.8831
533 AJ1 0.8830
534 11X 0.8829
535 PH2 0.8829
536 CWD 0.8828
537 68B 0.8828
538 SKF 0.8827
539 30G 0.8826
540 GOJ 0.8825
541 B21 0.8823
542 BNF 0.8823
543 8V8 0.8822
544 YIP 0.8821
545 8CC 0.8821
546 SB7 0.8820
547 CTN 0.8820
548 BIO 0.8819
549 HA5 0.8819
550 AES 0.8819
551 C2M 0.8819
552 CH8 0.8818
553 QBP 0.8818
554 PHB 0.8818
555 S60 0.8818
556 LJ4 0.8818
557 26C 0.8817
558 3QV 0.8816
559 F02 0.8816
560 0F9 0.8815
561 A5Q 0.8813
562 XYP XIF 0.8813
563 XIF XYP 0.8812
564 DEZ 0.8812
565 12T 0.8811
566 UN1 0.8811
567 FER 0.8810
568 2WU 0.8810
569 5GU 0.8809
570 8WO 0.8809
571 069 0.8809
572 5TY 0.8809
573 1X4 0.8809
574 1BN 0.8806
575 HBI 0.8806
576 HSO 0.8806
577 AMS 0.8805
578 KP2 0.8805
579 3QM 0.8805
580 72D 0.8805
581 UA5 0.8805
582 RKN 0.8804
583 4TU 0.8803
584 IQQ 0.8801
585 9JT 0.8800
586 4GU 0.8799
587 L5D 0.8796
588 FBF 0.8796
589 I1E 0.8795
590 THM 0.8795
591 TR4 0.8795
592 SX2 0.8795
593 WCU 0.8793
594 88L 0.8793
595 AEF 0.8792
596 5B2 0.8792
597 BX4 0.8791
598 MZR 0.8790
599 A7K 0.8789
600 E1T 0.8789
601 8ZE 0.8789
602 GGB 0.8788
603 B2Y 0.8788
604 6J9 0.8788
605 977 0.8786
606 BWD 0.8784
607 GLN 0.8782
608 XRS 0.8782
609 FUD 0.8781
610 NPO 0.8780
611 HBD 0.8779
612 IWD 0.8779
613 M78 0.8778
614 GJK 0.8778
615 K4V 0.8777
616 9CA 0.8777
617 MD6 0.8775
618 RP3 0.8775
619 Q04 0.8775
620 7ZL 0.8774
621 GJZ 0.8774
622 5WZ 0.8771
623 BP6 0.8771
624 E5X 0.8770
625 2UB 0.8770
626 DGN 0.8770
627 8OZ 0.8769
628 PHU 0.8769
629 F9P 0.8768
630 3Y7 0.8765
631 TSU 0.8764
632 ZSP 0.8761
633 CSN 0.8761
634 3C4 0.8759
635 LGT 0.8759
636 S7J 0.8759
637 7UZ 0.8758
638 8NX 0.8756
639 4NS 0.8755
640 V2Z 0.8754
641 N4E 0.8754
642 4MP 0.8754
643 S98 0.8754
644 3AE 0.8753
645 L1T 0.8753
646 8UY 0.8752
647 5F1 0.8752
648 5RP 0.8750
649 6J5 0.8750
650 QMP 0.8748
651 PYU 0.8747
652 6C8 0.8746
653 P2L 0.8746
654 1A5 0.8744
655 N0Z 0.8744
656 9BF 0.8743
657 6FG 0.8743
658 MTL 0.8741
659 BIK 0.8741
660 8U3 0.8741
661 AMQ 0.8741
662 5S9 0.8740
663 4Z9 0.8740
664 47V 0.8740
665 7FU 0.8739
666 H2B 0.8739
667 DGL 0.8739
668 YIE 0.8737
669 4AB 0.8737
670 RKV 0.8737
671 B4O 0.8736
672 7MU 0.8736
673 PAC 0.8734
674 1IT 0.8734
675 STX 0.8732
676 LT1 0.8732
677 92P 0.8732
678 2LT 0.8731
679 0XR 0.8730
680 N2Y 0.8730
681 C4E 0.8729
682 7EH 0.8729
683 4CN 0.8729
684 0OK 0.8728
685 ZHA 0.8727
686 GO8 0.8727
687 VM1 0.8726
688 PIQ 0.8726
689 DHB 0.8725
690 45L 0.8725
691 37E 0.8724
692 L14 0.8724
693 GLU 0.8723
694 4NZ 0.8723
695 0ON 0.8723
696 H75 0.8723
697 6C5 0.8723
698 DE3 0.8722
699 4NP 0.8722
700 E9S 0.8720
701 WOE 0.8719
702 6C4 0.8717
703 4JC 0.8717
704 ITE 0.8715
705 D9Z 0.8715
706 XRX 0.8715
707 EWG 0.8712
708 8OE 0.8712
709 D1G 0.8711
710 F18 0.8707
711 LR5 0.8704
712 AOY 0.8702
713 XDN XYP 0.8702
714 K82 0.8701
715 3PG 0.8701
716 AZM 0.8699
717 M4S 0.8698
718 6C9 0.8696
719 9W5 0.8696
720 FQX 0.8695
721 89J 0.8694
722 0DF 0.8694
723 PLR 0.8693
724 5DS 0.8691
725 49O 0.8690
726 MOK 0.8690
727 JLZ 0.8690
728 2O6 0.8689
729 WA1 0.8689
730 1FE 0.8689
731 1ER 0.8689
732 152 0.8688
733 THA 0.8688
734 2HU 0.8687
735 SW7 0.8687
736 F2W 0.8685
737 TCR 0.8684
738 TAG 0.8684
739 SAF 0.8683
740 3AD 0.8682
741 DRG 0.8682
742 MIL 0.8681
743 SHA 0.8680
744 BTM 0.8679
745 4J8 0.8676
746 22L 0.8675
747 2GD 0.8674
748 344 0.8674
749 B85 0.8674
750 42J 0.8673
751 MQN 0.8672
752 CIY 0.8671
753 NE1 0.8670
754 M4N 0.8670
755 4NM 0.8670
756 OKG 0.8669
757 42R 0.8666
758 4MB 0.8666
759 FCW 0.8666
760 5TO 0.8666
761 GLO 0.8665
762 SSC 0.8664
763 SLS 0.8664
764 U13 0.8662
765 K97 0.8661
766 GXD 0.8661
767 GVA 0.8660
768 DVQ 0.8660
769 B86 0.8657
770 KBZ 0.8656
771 54X 0.8655
772 RVE 0.8653
773 PNP 0.8653
774 CP6 0.8652
775 F69 0.8652
776 259 0.8650
777 86L 0.8649
778 BHS 0.8647
779 A3M 0.8646
780 API 0.8646
781 HG3 0.8645
782 1OS 0.8645
783 NF3 0.8644
784 8W9 0.8644
785 LDC 0.8643
786 MAH 0.8641
787 SSB 0.8637
788 0DN 0.8635
789 6RQ 0.8633
790 7L4 0.8633
791 N9M 0.8630
792 ANC 0.8630
793 JG8 0.8630
794 3SU 0.8629
795 72E 0.8629
796 WV7 0.8628
797 4EU 0.8627
798 3D1 0.8626
799 4CM 0.8624
800 PBQ 0.8623
801 PCQ 0.8623
802 64Z 0.8620
803 5AE 0.8620
804 C2Y 0.8619
805 P7V 0.8619
806 SD4 0.8617
807 H70 0.8616
808 DXK 0.8616
809 DBE 0.8615
810 TU0 0.8614
811 N2M 0.8613
812 A98 0.8611
813 HJ7 0.8611
814 4NR 0.8611
815 LOT 0.8611
816 0TU 0.8607
817 Z5P 0.8607
818 0OL 0.8605
819 HSX 0.8605
820 KDV 0.8605
821 PMP 0.8604
822 Q0K 0.8604
823 1HN 0.8603
824 6QF 0.8602
825 RP5 0.8598
826 7KE 0.8597
827 0OO 0.8597
828 FBS 0.8597
829 AM4 0.8594
830 BQ5 0.8593
831 1EB 0.8593
832 N7I 0.8592
833 PKU 0.8589
834 8WT 0.8589
835 1CY 0.8584
836 CUW 0.8581
837 DHM 0.8578
838 TVZ 0.8575
839 92O 0.8571
840 54F 0.8566
841 1KP 0.8559
842 SJK 0.8556
843 ADN 0.8550
844 3W8 0.8548
845 OCZ 0.8547
846 YI6 0.8546
847 R9Y 0.8540
848 ARJ 0.8539
849 VGD 0.8521
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2VJ8; Ligand: HA2; Similar sites found with APoc: 1
This union binding pocket(no: 1) in the query (biounit: 2vj8.bio1) has 40 residues
No: Leader PDB Ligand Sequence Similarity
1 6Q4R HJ5 24.5499
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