Receptor
PDB id Resolution Class Description Source Keywords
3D2U 2.21 Å NON-ENZYME: OTHER STRUCTURE OF UL18, A PEPTIDE-BINDING VIRAL MHC MIMIC, BOUND INHIBITORY RECEPTOR HUMAN HERPESVIRUS 5 MHC CLASS I HOMOLOG DISEASE MUTATION GLYCATION GLYCOPROTEIMMUNE RESPONSE IMMUNOGLOBULIN DOMAIN MHC I PYRROLIDONE CARBOXYLIC ACID SECRETED MEMBRANE PHOSPHOPROTEIN RECEPTTRANSMEMBRANE IMMUNE SYSTEM
Ref.: STRUCTURE OF UL18, A PEPTIDE-BINDING VIRAL MHC MIMI TO A HOST INHIBITORY RECEPTOR PROC.NATL.ACAD.SCI.USA V. 105 10095 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA LEU PRO HIS ALA ILE LEU ARG LEU C:1;
G:1;
Valid;
Valid;
none;
none;
submit data
1004.27 n/a O=C([...
BMA A:813;
Invalid;
none;
submit data
180.156 C6 H12 O6 C([C@...
FUC A:814;
Invalid;
none;
submit data
164.156 C6 H12 O5 C[C@H...
MAN A:812;
Invalid;
none;
submit data
180.156 C6 H12 O6 C([C@...
NAG A:861;
A:871;
A:891;
E:810;
E:861;
E:871;
E:891;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
NAG NAG A:810;
A:831;
E:831;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
408.404 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3D2U 2.21 Å NON-ENZYME: OTHER STRUCTURE OF UL18, A PEPTIDE-BINDING VIRAL MHC MIMIC, BOUND INHIBITORY RECEPTOR HUMAN HERPESVIRUS 5 MHC CLASS I HOMOLOG DISEASE MUTATION GLYCATION GLYCOPROTEIMMUNE RESPONSE IMMUNOGLOBULIN DOMAIN MHC I PYRROLIDONE CARBOXYLIC ACID SECRETED MEMBRANE PHOSPHOPROTEIN RECEPTTRANSMEMBRANE IMMUNE SYSTEM
Ref.: STRUCTURE OF UL18, A PEPTIDE-BINDING VIRAL MHC MIMI TO A HOST INHIBITORY RECEPTOR PROC.NATL.ACAD.SCI.USA V. 105 10095 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 3D2U - ALA LEU PRO HIS ALA ILE LEU ARG LEU n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 3D2U - ALA LEU PRO HIS ALA ILE LEU ARG LEU n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 3D2U - ALA LEU PRO HIS ALA ILE LEU ARG LEU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA LEU PRO HIS ALA ILE LEU ARG LEU; Similar ligands found: 139
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA LEU PRO HIS ALA ILE LEU ARG LEU 1 1
2 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.662162 0.969231
3 SER HIS PRO ARG PRO ILE ARG VAL 0.598639 0.913043
4 LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.586957 0.859375
5 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.545455 0.857143
6 HIS HIS ALA SER PRO ARG LYS 0.542484 0.852941
7 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.537975 0.895522
8 ILE LEU LYS GLU PRO VAL HIS GLY VAL 0.525 0.890625
9 ASN ARG PRO ILE LEU SER LEU 0.524138 0.842857
10 ASP ARG VAL TYR ILE HIS PRO PHE 0.520468 0.875
11 ALA MET ALA PRO ARG THR LEU LEU LEU 0.52027 0.794521
12 LEU PRO PHE GLU ARG ALA THR ILE MET 0.514793 0.810811
13 SER PRO LYS ARG ILE ALA 0.514085 0.865672
14 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.513699 0.852941
15 GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 0.513514 0.876923
16 GLU LEU PRO PRO VAL LYS ILE HIS CYS 0.508982 0.863636
17 ARG PRO LYS ARG ILE ALA 0.507042 0.90625
18 LYS ARG ARG ARG HIS PRO SER GLY 0.506667 0.814286
19 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.503311 0.855072
20 SER ARG ASP HIS SER ARG THR PRO MET 0.50303 0.813333
21 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.5 0.898551
22 5JP PRO LYS ARG ILE ALA 0.5 0.84058
23 HIS LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.5 0.848485
24 HIS LYS ILE LEU HIS ARG LEU LEU GLN GLU 0.496855 0.861538
25 LYS ARG ARG ARG HIS PRO SER 0.496644 0.850746
26 ALA LYS ARG HIS ARG LYS VAL LEU ARG ASP 0.493243 0.833333
27 DTY ILE ARG LEU LPD 0.493243 0.867647
28 LYS PRO ILE VAL VAL LEU HIS GLY TYR 0.491018 0.814286
29 ARG LEU TYR HIS SEP LEU PRO ALA 0.491018 0.772152
30 TYR PRO LYS ARG ILE ALA 0.490196 0.882353
31 ALA LYS ARG HIS ARG MLY VAL LEU ARG ASP 0.489933 0.828571
32 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.487179 0.847222
33 ALA ARG SER HIS SEP TYR PRO ALA 0.482143 0.7375
34 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.477987 0.924242
35 ARG ALA HIS SEP SER PRO ALA SER LEU GLN 0.477987 0.76
36 ARG HIS ARG MLY VAL LEU ARG ASP ASN 0.477419 0.816901
37 LYS PRO VAL LEU ARG THR ALA 0.473333 0.852941
38 GLU ARG THR ILE PRO ILE THR ARG GLU 0.473333 0.828571
39 HIS SER ILE THR TYR LEU LEU PRO VAL 0.473054 0.77027
40 VAL MET ALA PRO ARG THR LEU PHE LEU 0.46988 0.797297
41 ILE SER PRO ARG THR LEU ASP ALA TRP 0.469613 0.837838
42 LYS ILE LEU HIS ARG LEU LEU GLN ASP SER 0.469512 0.823529
43 ALA TRP ARG HIS PRO GLN PHE GLY GLY 0.468927 0.867647
44 GLY HIS ARG PRO 0.467626 0.90625
45 ARG SER HIS SEP SER PRO ALA SER LEU GLN 0.465517 0.802632
46 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.465409 0.863636
47 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.464706 0.8
48 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.463687 0.7375
49 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.462025 0.805556
50 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.461078 0.819444
51 ILE LEU MET GLU HIS ILE HIS LYS LEU 0.461039 0.710145
52 BOC HIS PRO PHE ALA LOV ILE HIS 0.460227 0.780822
53 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.460123 0.816901
54 LEU PRO PHE ASP ARG THR THR ILE MET 0.458824 0.8
55 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.458599 0.909091
56 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.458101 0.8
57 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.457516 0.838235
58 3BY PRO LYS ARG ILE ALA 0.456954 0.867647
59 LYS TYR TYR SER ILE ILE PRO HIS SER ILE 0.45679 0.746667
60 TYR TYR SER ILE ILE PRO HIS SER ILE 0.45679 0.746667
61 LEU PRO PHE GLU ARG ALA THR VAL MET 0.454023 0.797297
62 ILE LEU ALA LYS PHE LEU HIS ARG LEU 0.453416 0.830769
63 PRO PRO LYS ARG ILE ALA 0.453333 0.936508
64 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.452381 0.760563
65 GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS 0.451087 0.847222
66 ARG ARG ALA SEP ALA PRO LEU PRO 0.449367 0.783784
67 SER THR GLY GLY VAL M3L LYS PRO HIS ARG 0.448649 0.792208
68 LEU PRO PRO GLU GLU ARG LEU ILE 0.447368 0.9375
69 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.443709 0.794118
70 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.443038 0.880597
71 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.441558 0.808824
72 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.440994 0.77027
73 ALA ARG MLZ SER ALA PRO ALA THR 0.440789 0.791667
74 ALA ASN SER ARG ALY PRO THR SER ILE ILE 0.440476 0.808219
75 SER PRO ARG LEU PRO LEU LEU GLU SER 0.439189 0.904762
76 PRO HIS PRO PHE HIS STA VAL ILE HIS LYS 0.438503 0.788732
77 GLY ALA ARG ALA HIS SER SER 0.4375 0.732394
78 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.437126 0.763158
79 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.436709 0.742424
80 LYS PRO HIS SER ASP 0.436242 0.742857
81 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.435028 0.897059
82 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.433333 0.885714
83 SER LEU SER ARG THR PRO ALA ASP GLY ARG 0.432927 0.788732
84 SER GLU ILE GLU PHE ALA ARG LEU 0.432258 0.671429
85 SER HIS SEP SER PRO ALA SER LEU GLN 0.430233 0.75
86 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.428571 0.7
87 TYR TYR SER ILE ALA PRO HIS SER ILE 0.428571 0.723684
88 VAL TYR ILE HIS PRO PHE 0.427711 0.785714
89 LEU GLN ARG VAL LEU SEP ALA PRO PHE 0.427711 0.773333
90 DPN PRO DAR ILE NH2 0.427586 0.875
91 GLU LEU PRO LEU VAL LYS ILE 0.426667 0.796875
92 GLY HIS ARG PRO NH2 0.426573 0.875
93 HIS ALA TPO PRO PRO LYS LYS GLU ALA ASP 0.426136 0.72973
94 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.425287 0.77027
95 SER SER ILE GLU PHE ALA ARG LEU 0.424051 0.661972
96 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.424051 0.828571
97 ALA ILE HIS 0.424 0.68254
98 ALA LYS PHE ARG HIS ASP 0.422819 0.776119
99 PHE ASN GLU LEU SER HIS LEU 0.421429 0.666667
100 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.421053 0.810811
101 LYS GLY GLY ALA ALY ARG HIS ARG LYS VAL 0.421053 0.80597
102 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.420382 0.828571
103 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.420213 0.794872
104 ASP ALA GLU PHE ARG HIS ASP 0.42 0.761194
105 ACE ARG THR PRO SEP LEU PRO THR PIP 0.419753 0.734177
106 BOC HIS PRO PHE HIS LOV ILE HIS 0.418994 0.780822
107 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.418605 0.791667
108 PRO LYS LEU GLU PRO TRP LYS HIS PRO 0.418478 0.808824
109 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.418182 0.786667
110 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.418079 0.813333
111 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.417989 0.813333
112 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.416185 0.794118
113 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.41573 0.794521
114 SER HIS SEP SER PRO ALA SER LEU 0.415663 0.746667
115 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.413978 0.869565
116 PRO ARG ARG PRO VAL ILE MET ARG ARG 0.41358 0.852941
117 ALA ALA ARG KCR SER ALA PRO ALA 0.41358 0.8
118 HIS VAL GLY PRO ILE ALA 0.413333 0.875
119 SER ASP ILE LEU PHE PRO ALA ASP SER 0.4125 0.732394
120 HIS ALA GLY PRO ILE ALA 0.412162 0.846154
121 ARG PRO MET THR PHE LYS GLY ALA LEU 0.411111 0.786667
122 SER ALA GLU PRO VAL PRO LEU GLN LEU 0.410256 0.757143
123 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.410112 0.772152
124 DHI PRO PHE HIS LEU LEU VAL TYR 0.410112 0.785714
125 LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL 0.409396 0.890625
126 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.409357 0.782609
127 VAL PRO LEU ARG PRO MET THR TYR 0.409357 0.789474
128 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.409326 0.78481
129 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.408284 0.732394
130 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.406593 0.885714
131 ARG PRO MET THR TYR LYS GLY ALA LEU 0.406593 0.779221
132 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.406452 0.788732
133 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.406061 0.855072
134 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.405882 0.739726
135 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.405714 0.794118
136 ARG PHE PRO LEU THR PHE GLY TRP 0.404372 0.835616
137 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.403061 0.78481
138 PRO HIS PRO PHE HIS LAV ILE HIS LYS 0.401099 0.818182
139 ACE ARG THR PRO SEP LEU PRO THR 60H 0.4 0.746835
Similar Binding Sites (Proteins are less than 50% similar to leader)
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