Receptor
PDB id Resolution Class Description Source Keywords
3D2U 2.21 Å NON-ENZYME: OTHER STRUCTURE OF UL18, A PEPTIDE-BINDING VIRAL MHC MIMIC, BOUND INHIBITORY RECEPTOR HUMAN HERPESVIRUS 5 MHC CLASS I HOMOLOG DISEASE MUTATION GLYCATION GLYCOPROTEIMMUNE RESPONSE IMMUNOGLOBULIN DOMAIN MHC I PYRROLIDONE CARBOXYLIC ACID SECRETED MEMBRANE PHOSPHOPROTEIN RECEPTTRANSMEMBRANE IMMUNE SYSTEM
Ref.: STRUCTURE OF UL18, A PEPTIDE-BINDING VIRAL MHC MIMI TO A HOST INHIBITORY RECEPTOR PROC.NATL.ACAD.SCI.USA V. 105 10095 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA LEU PRO HIS ALA ILE LEU ARG LEU C:1;
G:1;
Valid;
Valid;
none;
none;
submit data
1004.27 n/a O=C([...
BMA A:813;
Invalid;
none;
submit data
180.156 C6 H12 O6 C([C@...
FUC A:814;
Invalid;
none;
submit data
164.156 C6 H12 O5 C[C@H...
MAN A:812;
Invalid;
none;
submit data
180.156 C6 H12 O6 C([C@...
NAG A:861;
A:871;
A:891;
E:810;
E:861;
E:871;
E:891;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
NAG NAG A:810;
A:831;
E:831;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
408.404 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3D2U 2.21 Å NON-ENZYME: OTHER STRUCTURE OF UL18, A PEPTIDE-BINDING VIRAL MHC MIMIC, BOUND INHIBITORY RECEPTOR HUMAN HERPESVIRUS 5 MHC CLASS I HOMOLOG DISEASE MUTATION GLYCATION GLYCOPROTEIMMUNE RESPONSE IMMUNOGLOBULIN DOMAIN MHC I PYRROLIDONE CARBOXYLIC ACID SECRETED MEMBRANE PHOSPHOPROTEIN RECEPTTRANSMEMBRANE IMMUNE SYSTEM
Ref.: STRUCTURE OF UL18, A PEPTIDE-BINDING VIRAL MHC MIMI TO A HOST INHIBITORY RECEPTOR PROC.NATL.ACAD.SCI.USA V. 105 10095 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 3D2U - ALA LEU PRO HIS ALA ILE LEU ARG LEU n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 3D2U - ALA LEU PRO HIS ALA ILE LEU ARG LEU n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 3D2U - ALA LEU PRO HIS ALA ILE LEU ARG LEU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA LEU PRO HIS ALA ILE LEU ARG LEU; Similar ligands found: 158
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA LEU PRO HIS ALA ILE LEU ARG LEU 1 1
2 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.696552 0.969231
3 SER HIS PRO ARG PRO ILE ARG VAL 0.586667 0.913043
4 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.564935 0.857143
5 HIS HIS ALA SER PRO ARG LYS 0.558442 0.852941
6 ALA ILE LEU HIS ARG LEU LEU GLN 0.548611 0.828125
7 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.54375 0.895522
8 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.540541 0.907692
9 ASN ARG PRO ILE LEU SER LEU 0.537931 0.842857
10 ALA ASN SER ARG HIS PRO THR SER ILE ILE 0.532468 0.885714
11 ALA MET ALA PRO ARG THR LEU LEU LEU 0.530201 0.794521
12 LEU PRO PHE GLU ARG ALA THR ILE MET 0.526627 0.810811
13 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.522293 0.938462
14 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.519737 0.842857
15 ALA PHE ARG ILE PRO LEU THR ARG 0.518987 0.857143
16 ARG PRO LYS ARG ILE ALA 0.517241 0.90625
17 GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 0.513158 0.876923
18 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.510067 0.852941
19 ILE LEU LYS GLU PRO VAL HIS GLY VAL 0.509202 0.90625
20 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.508475 0.898551
21 LYS ARG ARG ARG HIS PRO SER GLY 0.506494 0.814286
22 SER ARG ASP HIS SER ARG THR PRO MET 0.505952 0.813333
23 ARG LEU TYR HIS SEP LEU PRO ALA 0.502959 0.772152
24 LYS ARG ARG ARG HIS PRO SER 0.5 0.850746
25 HIS LYS ILE LEU HIS ARG LEU LEU GLN GLU 0.5 0.861538
26 HIS LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.496815 0.830769
27 TYR PRO LYS ARG ILE ALA 0.496774 0.882353
28 LYS PRO VAL LEU ARG THR ALA 0.493421 0.852941
29 DTY ILE ARG LEU LPD 0.493243 0.867647
30 PHE LEU PRO HIS ALY TYR ASP VAL LYS LEU 0.491429 0.777778
31 GLU LEU PRO PRO VAL LYS ILE HIS CYS 0.491329 0.878788
32 LYS ILE LEU HIS ARG LEU LEU GLN ASP SER 0.490909 0.823529
33 ALA LYS ARG HIS ARG LYS VAL LEU ARG ASP 0.490066 0.84127
34 ILE SER PRO ARG THR LEU ASP ALA TRP 0.488889 0.837838
35 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.484472 0.924242
36 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.484076 0.893939
37 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.483444 0.828571
38 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.483146 0.7375
39 ILE PRO LEU THR GLU GLU ALA GLU LEU 0.482993 0.753623
40 ARG HIS ARG MLY VAL LEU ARG ASP ASN 0.481013 0.816901
41 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.480769 0.909091
42 LYS PRO ILE VAL VAL LEU HIS GLY TYR 0.479532 0.828571
43 ALA ARG SER HIS SEP TYR PRO ALA 0.479532 0.7375
44 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.476744 0.837838
45 VAL MET ALA PRO ARG THR LEU PHE LEU 0.47619 0.797297
46 HIS SER ILE THR TYR LEU LEU PRO VAL 0.47619 0.783784
47 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.475 0.863636
48 ARG ALA HIS SEP SER PRO ALA SER LEU GLN 0.475 0.773333
49 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.472527 0.826667
50 LEU PRO PHE GLU ARG ALA THR VAL MET 0.471264 0.797297
51 ALA ARG MLZ SER ALA PRO ALA THR 0.470968 0.77027
52 BOC HIS PRO PHE ALA LOV ILE HIS 0.468927 0.794521
53 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.46875 0.805556
54 ARG ARG ALA SEP ALA PRO LEU PRO 0.468354 0.783784
55 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.468208 0.814286
56 LEU PRO PHE ASP ARG THR THR ILE MET 0.467836 0.8
57 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.467456 0.819444
58 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.464516 0.838235
59 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.464052 0.794118
60 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.461538 0.8
61 3BY PRO LYS ARG ILE ALA 0.461039 0.867647
62 MET CYS PRO ARG MET THR ALA VAL MET 0.457317 0.794521
63 GLU ARG THR ILE PRO ILE THR ARG GLU 0.456954 0.826087
64 LEU PRO PRO GLU GLU ARG LEU ILE 0.454545 0.9375
65 LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.454545 0.765625
66 TYR TYR SER ILE ILE PRO HIS SER ILE 0.453988 0.76
67 LYS TYR TYR SER ILE ILE PRO HIS SER ILE 0.453988 0.76
68 GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS 0.452128 0.847222
69 PRO PRO LYS ARG ILE ALA 0.451613 0.936508
70 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.450331 0.848485
71 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.45 0.808824
72 LEU GLN ARG VAL LEU SEP ALA PRO PHE 0.448485 0.773333
73 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.447853 0.77027
74 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.447205 0.880597
75 ALA ASN SER ARG ALY PRO THR SER ILE ILE 0.447059 0.808219
76 SER THR GLY GLY VAL M3L LYS PRO HIS ARG 0.446809 0.792208
77 ILE LEU MET GLU HIS ILE HIS LYS LEU 0.44586 0.73913
78 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.445652 0.885714
79 ILE LEU ALA LYS PHE LEU HIS ARG LEU 0.445122 0.830769
80 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.445087 0.774648
81 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.443787 0.763158
82 SER PRO ARG LEU PRO LEU LEU GLU SER 0.442953 0.904762
83 SER LEU SER ARG THR PRO ALA ASP GLY ARG 0.442424 0.788732
84 SER GLU ILE GLU PHE ALA ARG LEU 0.43949 0.671429
85 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.439024 0.797101
86 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.4375 0.828571
87 SER PRO LYS ARG ILE ALA 0.436242 0.850746
88 GLY ALA ARG ALA HIS SER SER 0.435374 0.732394
89 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.435028 0.813333
90 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.434783 0.786667
91 TYR TYR SER ILE ALA PRO HIS SER ILE 0.434524 0.736842
92 ARG PHE PRO LEU THR PHE GLY TRP 0.434066 0.835616
93 ARG PRO MET THR PHE LYS GLY ALA LEU 0.434066 0.786667
94 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.433155 0.815789
95 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.432927 0.855072
96 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.432749 0.810811
97 ARG PRO MET THR TYR LYS GLY ALA LEU 0.431694 0.779221
98 SER SER ILE GLU PHE ALA ARG LEU 0.43125 0.661972
99 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.431034 0.791667
100 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.430168 0.772152
101 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.428571 0.897059
102 BOC HIS PRO PHE HIS LOV ILE HIS 0.427778 0.794521
103 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.427746 0.77027
104 LYS PRO HIS SER ASP 0.427632 0.757143
105 GLY HIS ARG PRO NH2 0.427586 0.875
106 HIS ALA TPO PRO PRO LYS LYS GLU ALA ASP 0.426966 0.756757
107 VAL PRO LEU ARG PRO MET THR TYR 0.426901 0.789474
108 DPN PRO DAR ILE NH2 0.425676 0.875
109 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.425532 0.869565
110 ILE GLU GLU ALA LEU GLN ILE ILE HIS SER 0.425 0.731343
111 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.424084 0.794872
112 5JP PRO LYS ARG ILE ALA 0.423611 0.785714
113 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.423313 0.728571
114 PRO ARG ARG PRO VAL ILE MET ARG ARG 0.423313 0.852941
115 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.42236 0.772727
116 ALA LYS PHE ARG HIS ASP 0.422078 0.776119
117 ARG THR PRO SEP LEU PRO THR 0.421384 0.773333
118 ALA ALA ARG KCR SER ALA PRO ALA 0.420732 0.8
119 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.41875 0.828571
120 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.418367 0.813333
121 ARG TYR PRO LEU THR PHE GLY TRP 0.417989 0.813333
122 ALA ILE HIS 0.417323 0.698413
123 ARG THR PHE SER PRO THR TYR GLY LEU 0.417143 0.776316
124 PRO HIS PRO PHE HIS LAV ILE HIS LYS 0.416667 0.848485
125 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.41573 0.714286
126 ALA LYS ARG HIS ARG MLY VAL LEU ARG ASP 0.415663 0.823529
127 PHE ASN GLU LEU SER HIS LEU 0.415493 0.681159
128 ACE ARG THR PRO SEP LEU PRO THR PIP 0.414634 0.734177
129 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.414141 0.792208
130 GLY HIS ARG PRO 0.413793 0.875
131 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.413265 0.78481
132 ARG VAL ALA SER PRO THR SER GLY VAL 0.4125 0.788732
133 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.412371 0.813333
134 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.411765 0.753425
135 SER ALA GLU PRO VAL PRO LEU GLN LEU 0.411392 0.757143
136 ALA LYS ARG HIS ARG MLZ VAL LEU ARG ASP 0.411043 0.779412
137 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.410714 0.869565
138 ASP ARG VAL TYR ILE HIS PRO PHE 0.410596 0.797101
139 ARG ARG ARG GLU ARG SER PRO THR ARG 0.409938 0.774648
140 CYS THR PRO SER ARG 0.409396 0.760563
141 HIS ALA GLY PRO ILE ALA 0.409396 0.876923
142 VAL PRO LEU THR GLU ASP ALA GLU LEU 0.407643 0.714286
143 GLU LEU PRO LEU VAL LYS ILE 0.407643 0.828125
144 VAL TYR PRO IAS HIS ALA 0.407407 0.763889
145 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.407035 0.78481
146 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.40678 0.808824
147 LEU PRO SER PHE GLU THR ALA LEU 0.406061 0.722222
148 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.405556 0.794521
149 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.405405 0.885714
150 ACE GLN GLU ARG GLU VAL PRO CYS 0.403846 0.863636
151 SER ALA PRO ASP THR ARG PRO ALA 0.403727 0.791667
152 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.403509 0.746479
153 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.403061 0.792208
154 LEU ASP PRO ARG 0.401361 0.876923
155 HIS VAL GLY PRO ILE ALA 0.401316 0.90625
156 ILE PRO ALA TYR GLY VAL LEU THR ILE 0.4 0.75
157 ACE PRO LEU HIS SER TPO ALA NH2 0.4 0.730769
158 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.4 0.690141
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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