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Receptor
PDB id Resolution Class Description Source Keywords
3CF6 2.2 Å NON-ENZYME: OTHER STRUCTURE OF EPAC2 IN COMPLEX WITH CYCLIC-AMP AND RAP MUS MUSCULUS EPAC RAPGEF4 RAP RAP1B CAMP SP-CAMPS GEF GUNANINE NUCEXCHANGE FACTOR G-PROTEIN GTP-BINDING NUCLEOTIDE-BINDINGSIGNALING PROTEIN REGULATOR-GTP-BINDING PROTEIN COMPLEX SIPROTEIN-GTP-BINDING PROTEIN COMPLEX
Ref.: STRUCTURE OF EPAC2 IN COMPLEX WITH A CYCLIC AMP ANA RAP1B NATURE V. 455 124 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 R:168;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
SP1 E:2;
E:3;
Valid;
Valid;
none;
none;
submit data
345.272 C10 H12 N5 O5 P S c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3CF6 2.2 Å NON-ENZYME: OTHER STRUCTURE OF EPAC2 IN COMPLEX WITH CYCLIC-AMP AND RAP MUS MUSCULUS EPAC RAPGEF4 RAP RAP1B CAMP SP-CAMPS GEF GUNANINE NUCEXCHANGE FACTOR G-PROTEIN GTP-BINDING NUCLEOTIDE-BINDINGSIGNALING PROTEIN REGULATOR-GTP-BINDING PROTEIN COMPLEX SIPROTEIN-GTP-BINDING PROTEIN COMPLEX
Ref.: STRUCTURE OF EPAC2 IN COMPLEX WITH A CYCLIC AMP ANA RAP1B NATURE V. 455 124 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
70% Homology Family (34)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 250 families.
1 5WFO - 5UU C19 H16 Cl F N2 c1cc(ccc1N....
2 6FA3 Kd = 0.038 uM D1Z C30 H36 N4 O5 CN(C)Cc1cc....
3 5WFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
4 5O2T Kd = 3.9 nM GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
5 5WPM - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
6 5WFR - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
7 5UFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
8 6AMB - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
9 6FA1 - D2Z C20 H25 N2 O4 C[NH+](C)C....
10 5UFE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
11 5WFP - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
12 5WHB - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
13 5WPL - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
14 5XCO - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
15 1NVU - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
16 5WHE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
17 3KUC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
18 1C1Y - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
19 5TAR - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
20 4DXA - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
21 4HDO - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
22 5E95 Kd = 15.7 nM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
23 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
24 6FA4 Kd = 0.051 uM D1W C23 H25 N3 O3 CN(C)Cc1cc....
25 2C5L - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
26 4K81 - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
27 1LFD - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
28 4KVG - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
29 1WQ1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
30 3DDC - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
31 3KUD - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
32 4URZ Kd = 3 mM VJP C11 H14 N2 O3 S c1cc(ccc1N....
33 4URX Kd = 1.3 mM HXY C11 H14 Br N c1cc(ccc1C....
34 4URY Kd = 6 mM RV1 C10 H12 N2 O3 S c1cc(ccc1N....
50% Homology Family (47)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 204 families.
1 3QBT - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
2 5WFO - 5UU C19 H16 Cl F N2 c1cc(ccc1N....
3 6FA3 Kd = 0.038 uM D1Z C30 H36 N4 O5 CN(C)Cc1cc....
4 5WFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
5 5O2T Kd = 3.9 nM GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
6 5WPM - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
7 5WFR - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
8 5UFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
9 6AMB - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
10 6FA1 - D2Z C20 H25 N2 O4 C[NH+](C)C....
11 5UFE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
12 5WFP - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
13 5WHB - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
14 5WPL - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
15 5XCO - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
16 1NVU - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
17 5WHE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
18 3KUC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
19 1C1Y - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
20 5TAR - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
21 4DXA - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
22 4HDO - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
23 3MJH - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
24 5E95 Kd = 15.7 nM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
25 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
26 2CJW Kd = 2.5 uM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
27 6FA4 Kd = 0.051 uM D1W C23 H25 N3 O3 CN(C)Cc1cc....
28 2C5L - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
29 4K81 - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
30 1LFD - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
31 4KVG - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
32 3TNF - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
33 1ZC4 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
34 1ZC3 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
35 2A9K - NAD C21 H27 N7 O14 P2 c1cc(c[n+]....
36 2A78 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
37 1WQ1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
38 3TKL - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
39 3DDC - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
40 3KUD - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
41 1TU3 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
42 1UAD Ka = 7260000 M^-1 GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
43 5O74 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
44 3SFV - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
45 4URZ Kd = 3 mM VJP C11 H14 N2 O3 S c1cc(ccc1N....
46 4URX Kd = 1.3 mM HXY C11 H14 Br N c1cc(ccc1C....
47 4URY Kd = 6 mM RV1 C10 H12 N2 O3 S c1cc(ccc1N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SP1; Similar ligands found: 85
No: Ligand ECFP6 Tc MDL keys Tc
1 RP1 1 1
2 SP1 1 1
3 CMP 0.757143 0.928571
4 2BA 0.757143 0.915493
5 1YD 0.580645 0.844156
6 4BW 0.580645 0.844156
7 Y3J 0.542857 0.702703
8 5AD 0.529412 0.722222
9 QQX 0.519481 0.90411
10 RAB 0.514286 0.77027
11 ADN 0.514286 0.77027
12 XYA 0.514286 0.77027
13 5CD 0.513889 0.756757
14 1SY 0.509615 0.844156
15 CC5 0.5 0.791667
16 4UR 0.5 0.844156
17 5N5 0.5 0.746667
18 A4D 0.493151 0.77027
19 MTA 0.480519 0.75
20 75G 0.476744 0.932432
21 EP4 0.473684 0.708861
22 1OR 0.472527 0.759036
23 M2T 0.467532 0.7125
24 DTA 0.467532 0.810811
25 7D7 0.458333 0.72
26 ACK 0.45679 0.835616
27 3AD 0.453333 0.780822
28 SRA 0.451219 0.918919
29 1YC 0.45098 0.818182
30 3DH 0.45 0.75
31 3AM 0.444444 0.851351
32 J7C 0.440476 0.703704
33 AMP 0.439024 0.864865
34 A 0.439024 0.864865
35 LMS 0.439024 0.804878
36 ZAS 0.439024 0.721519
37 QQY 0.439024 0.890411
38 6RE 0.433735 0.695122
39 2AM 0.432099 0.84
40 NEC 0.428571 0.679487
41 AOC 0.428571 0.75
42 DSH 0.428571 0.703704
43 A3G 0.428571 0.730769
44 6SX 0.425287 0.885714
45 A2D 0.423529 0.866667
46 A3N 0.423529 0.717949
47 ABM 0.423529 0.842105
48 EEM 0.419355 0.651163
49 GJV 0.418605 0.686747
50 S4M 0.418605 0.647727
51 OVE 0.416667 0.88
52 6SZ 0.41573 0.915493
53 ADX 0.41573 0.82716
54 7CH 0.413793 0.914286
55 A12 0.413793 0.810127
56 A3P 0.413793 0.864865
57 BA3 0.413793 0.866667
58 AP2 0.413793 0.810127
59 MAO 0.413793 0.697674
60 SFG 0.411111 0.705128
61 50T 0.411111 0.831169
62 5X8 0.411111 0.74026
63 S7M 0.410526 0.670588
64 AP5 0.409091 0.866667
65 5AS 0.409091 0.758621
66 ADP 0.409091 0.842105
67 B4P 0.409091 0.866667
68 APC 0.406593 0.810127
69 5F1 0.405063 0.688312
70 AT4 0.404494 0.881579
71 SON 0.404494 0.810127
72 A3S 0.404494 0.74026
73 A7D 0.404494 0.753247
74 AN2 0.404494 0.831169
75 7D5 0.402439 0.805195
76 AD9 0.402174 0.820513
77 SA8 0.402174 0.666667
78 SAP 0.402174 0.894737
79 AGS 0.402174 0.894737
80 AU1 0.4 0.820513
81 N6R 0.4 0.853333
82 CA0 0.4 0.820513
83 MHZ 0.4 0.659091
84 N6S 0.4 0.853333
85 M33 0.4 0.831169
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found with APoc: 404
This union binding pocket(no: 1) in the query (biounit: 3cf6.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 3PP0 03Q 1.79641
2 4FL3 ANP 1.79641
3 6C0T EE4 2.01729
4 2OJW ADP 2.08333
5 2WSI FAD 2.28758
6 3LXK MI1 2.44648
7 3NYQ MCA 2.57426
8 4GLL NAD 2.67062
9 3VHE 42Q 2.99401
10 5DX9 T6P 2.99401
11 5UIU 8CG 2.99401
12 6CQF F97 3.0303
13 5A5W GUO 3.16206
14 4DPL NAP 3.34262
15 5UWA 8ND 3.44828
16 3BJU ATP 3.45489
17 4YZC STU 3.59281
18 5L13 6ZE 3.59281
19 1T7Q COA 3.59281
20 1T7Q 152 3.59281
21 4GAH 0ET 3.59281
22 4EIL FOL 3.59281
23 6FK3 PPI 3.59281
24 3H86 AP5 3.59281
25 4B0T ADP 3.65112
26 2AG4 OLA 3.65854
27 2AG4 LP3 3.65854
28 3ETH ATP 3.66197
29 2WOX NDP 3.68098
30 1U5R ATP 3.73563
31 5IUW NAD 3.82294
32 2V1O COA 3.97351
33 5UR0 NAD 4.01146
34 4KS7 X4Z 4.19162
35 5OMY 9YE 4.19162
36 3PE2 E1B 4.19162
37 4NV7 COA 4.19162
38 6G0X RAM GLC GLA NAG NDG NAG 4.19162
39 3ALN ANP 4.19162
40 4OTH DRN 4.19162
41 4PNI KQQ 4.19162
42 1XJD STU 4.19162
43 4U0I 0LI 4.19162
44 1BYG STU 4.19162
45 3QWB NDP 4.19162
46 4XDA RIB 4.19162
47 4XDA ADP 4.19162
48 4UAL 3FV 4.19162
49 4L9I 8PR 4.19162
50 4JK3 NAD 4.19162
51 3ZGJ RMN 4.19162
52 3G5D 1N1 4.1958
53 5EXK MET 4.22961
54 1XCL SAH 4.25532
55 1PN4 HDC 4.28571
56 1MVN PCO 4.30622
57 6GNO XDI 4.44444
58 4Y24 TD2 4.54545
59 1MDC PLM 4.54545
60 5JFS 6K0 4.54545
61 5A3T MMK 4.7817
62 4L3L 5FI 4.79042
63 3GQI ACP 4.79042
64 1H8S AIC 4.79042
65 1L2T ATP 4.79042
66 5I60 67W 4.79042
67 5FQK 6NT 4.79042
68 5DY5 5GR 4.79042
69 5KBZ 3B2 4.79042
70 2GMH FAD 4.79042
71 1ODM ASV 4.79042
72 3RHJ NAP 4.79042
73 2IV2 MGD 4.79042
74 6GZD LCI 4.79042
75 5A6N U7E 4.79042
76 1LLU NAD 4.79042
77 5FP4 YC8 4.79042
78 1TED MYR 4.83461
79 2HI4 BHF 4.84848
80 4MZQ 1VU 4.86111
81 3E2M E2M 4.86486
82 2YAK OSV 4.91228
83 5UR6 8KM 4.97238
84 4ORM 2V6 4.98753
85 4ORM FMN 4.98753
86 4ORM ORO 4.98753
87 4GO7 THR 5
88 6EHH 2GE 5.11364
89 5KZD RCJ 5.11945
90 5UR1 YY9 5.14469
91 3KRL KRL 5.37313
92 2JDR L20 5.38922
93 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 5.38922
94 3C2O NTM 5.38922
95 5DRB 5FJ 5.38922
96 6B5G CQY 5.38922
97 5TO8 7FM 5.38922
98 3OIX FMN 5.38922
99 2JIG PD2 5.38922
100 4NZN 2OU 5.38922
101 4NZN ANP 5.38922
102 6FNU FAD 5.38922
103 3VC1 SAH 5.38922
104 6B5G NAD 5.38922
105 3VC1 GST 5.38922
106 5UCD NAP 5.38922
107 4LH0 GLV 5.38922
108 5EFQ ADP 5.38922
109 3HAZ NAD 5.38922
110 1JG3 VAL TYR PRO IAS HIS ALA 5.38922
111 4PXL NAD 5.38922
112 3RFA SAM 5.38922
113 4QTB 38Z 5.38922
114 2YW2 ATP 5.38922
115 5MKG C2E 5.38922
116 1RY2 AMP 5.38922
117 4U0S ADP 5.38922
118 2I4I AMP 5.38922
119 1ELI PYC 5.39846
120 5M06 ADP 5.43478
121 5JSP DQY 5.47264
122 1TT8 PHB 5.4878
123 4IEN COA 5.52147
124 4QAC KK3 5.52995
125 4NW6 2NS 5.57276
126 1I1E DM2 5.6196
127 6FYV 3NG 5.63798
128 1H5Q NAP 5.66038
129 4K39 SAM 5.67568
130 4K37 SAM 5.67568
131 4PVD NDP 5.84795
132 1MI3 NAD 5.90062
133 4LRJ ANP 5.91716
134 4K3H 1OM 5.9322
135 1OFU GDP 5.9375
136 2ET1 GLV 5.97015
137 4GJ3 0XP 5.98802
138 3LXN MI1 5.98802
139 4BNU 9KQ 5.98802
140 1QPR PPC 5.98802
141 3ITJ FAD 5.98802
142 4IZY 1J2 5.98802
143 4O9S 2RY 5.98802
144 1RE8 BD2 5.98802
145 2Z48 NGA 5.98802
146 3EYA FAD 5.98802
147 6C6O ENG 5.98802
148 2ABS ACP 5.98802
149 4MP8 MLI 5.98802
150 4MP8 NAD 5.98802
151 4UX9 ANP 5.98802
152 1ZB6 GST 5.98802
153 4URF NAD 5.98802
154 6GQM F8H 5.98802
155 2Z49 AMG 5.98802
156 4J7H TLO 5.98802
157 1ERB ETR 6.01093
158 5BVE 4VG 6.09418
159 3A6T 8OG 6.20155
160 4WOP CTP 6.22222
161 3VZS NAP 6.22568
162 3VZS CAA 6.22568
163 5OVL NAP 6.33333
164 4KBA 1QM 6.34441
165 5T7I LAT NAG GAL 6.45161
166 1W8S FBP 6.46388
167 2YKL NLD 6.58683
168 4N70 2HX 6.58683
169 3BZ3 YAM 6.58683
170 2Y4O DLL 6.58683
171 3UDZ ADP 6.58683
172 2R5T ANP 6.58683
173 6FL8 ADP 6.58683
174 6FL8 TIY 6.58683
175 2GMV UN8 6.58683
176 2V58 LZJ 6.58683
177 1PZ0 NAP 6.58683
178 5U6C 7YS 6.58683
179 1NHX FTB 6.58683
180 3IX9 MTX 6.58683
181 5ZCT ANP 6.58683
182 1IA9 ANP 6.58683
183 2CHG ANP 6.58683
184 2Y6O 1N1 6.58683
185 4JBI NDP 6.58683
186 3OV6 MK0 6.58683
187 3LU1 NAD 6.59341
188 4NBW NAD 6.61479
189 4ZLU 4PW 6.71141
190 4ZLU ADP 6.71141
191 4BG4 ADP 6.74157
192 2WU6 DKI 6.82415
193 5MJA 7O3 6.88525
194 3VPC ADP 7.0922
195 5L8L ADP 7.18563
196 4ZA2 NAD 7.18563
197 4NBT NAD 7.18563
198 3RWP ABQ 7.18563
199 4A0M NAD 7.18563
200 1OLM VTQ 7.18563
201 2QUN FUD 7.18563
202 2II3 CAO 7.18563
203 2RG0 CTT 7.18563
204 2GVJ DGB 7.18563
205 1YB5 NAP 7.18563
206 2DBZ NAP 7.18563
207 1O9J NAD 7.18563
208 5GLN XYS 7.18563
209 5YU3 PRO 7.26744
210 5YU3 NAD 7.26744
211 4IPH 1FJ 7.31707
212 3CW9 01A 7.34127
213 4K49 HFQ 7.35294
214 5OVK NDP 7.42188
215 4XV1 904 7.53425
216 2JLD AG1 7.78443
217 4ITH RCM 7.78443
218 4X3R 686 7.78443
219 2RKV COA 7.78443
220 6MVU K4V 7.78443
221 1W5F G2P 7.78443
222 3GNI ATP 7.78443
223 3IUY AMP 7.78443
224 5AOV NAP 7.78443
225 5HCY 60D 7.85498
226 4E1Z 0MX 7.90378
227 1MEX RAC 7.98122
228 5XQW 8EU 8.05687
229 5TKJ ALA VAL GLY ILE GLY ALA VAL PHE 8.1448
230 5IVE 6E8 8.18182
231 3K5I ADP 8.38323
232 5IH9 6BF 8.38323
233 2RIO ADP 8.38323
234 5HES 032 8.38323
235 3K5I AIR 8.38323
236 1H2B NAJ 8.38323
237 6EWZ APC 8.38323
238 5XDT ZI7 8.38323
239 3RIY NAD 8.38323
240 1V8B NAD 8.38323
241 1Q23 FUA 8.38323
242 2E27 AB0 8.40336
243 4CQM NAP 8.42912
244 3A16 PXO 8.57909
245 4Q9N NAI 8.72483
246 3ABI NAD 8.76712
247 5EPO NAP 8.77863
248 5XVG 8FX 8.98204
249 6A1G 9OL 8.98204
250 1XMV ADP 8.98204
251 4A4X JUP 8.98204
252 3C6K MTA 8.98204
253 3C6K SPD 8.98204
254 4FE2 AIR 8.98204
255 3G6K FAD 8.98204
256 3G6K POP 8.98204
257 4RF2 NAP 8.98204
258 1S7G NAD 8.98204
259 1U59 STU 8.98204
260 2XCG XCG 9.03846
261 3MVH WFE 9.06433
262 3PVW QRX 9.45946
263 1OBD ATP 9.47712
264 1NB9 RBF 9.52381
265 1NB9 ADP 9.52381
266 4CLI 5P8 9.58084
267 4I9A NCN 9.58084
268 1VL8 NAP 9.58084
269 2PYW ADP 9.58084
270 1I8T FAD 9.58084
271 1XLI GLT 9.58084
272 6FCX FAD 9.58084
273 2OFV 242 9.58084
274 4QDF 30Q 9.58084
275 5A89 FMN 9.61539
276 5A89 ADP 9.61539
277 2E56 MYR 9.72222
278 1N07 FMN 9.81595
279 1ZPT FAD 9.86842
280 5CAE SIN 9.87342
281 5CAE COA 9.87342
282 5DQ8 FLF 10
283 1GT4 UNA 10.0629
284 3AB4 THR 10.1124
285 4ZSI GLP 10.1796
286 6MPT C30 10.1796
287 5H9Y BGC BGC BGC BGC 10.1796
288 1VDC FAD 10.1796
289 2WQN ADP 10.1796
290 2JG1 ANP 10.1796
291 2VPQ ANP 10.1796
292 2BNE U5P 10.1796
293 6BXI ANP 10.1796
294 1KGI T4A 10.2362
295 3HCH RSM 10.274
296 4WVW SLT 10.4167
297 3AJH BL3 10.4839
298 5N5S NAP 10.7784
299 5C03 AGS 10.7784
300 4R1S NAP 10.7784
301 2A19 ANP 10.7784
302 1V59 NAD 10.7784
303 4WO4 JLS 11
304 5WL1 D3D 11.1111
305 5WL1 CUY 11.1111
306 3OFK SAH 11.1111
307 2FB3 5AD 11.1765
308 1OS7 TAU 11.3074
309 1OS7 AKG 11.3074
310 3EKK GS2 11.3772
311 2I6A 5I5 11.5942
312 4IMG NGF 11.976
313 1OUK 084 11.976
314 3AD8 PYC 11.976
315 3AD8 FAD 11.976
316 1Q0H NDP 11.976
317 1Q0H FOM 11.976
318 4K33 ACP 11.976
319 2DKH FAD 11.976
320 1QF5 GDP 11.976
321 1QF5 RPL 11.976
322 2IO8 ADP 11.976
323 2C29 NAP 11.976
324 1N62 MCN 12.0482
325 2R75 01G 12.1302
326 4GKV NAD 12.5
327 3VPB ADP 12.5
328 1ZY5 ANP 12.5749
329 1RJW ETF 12.5749
330 3N3T C2E 12.5749
331 5G1X ADP 12.6984
332 3H0L ADP 12.766
333 4R38 RBF 12.8571
334 4UXL 5P8 13.1737
335 1C5C TK4 13.1737
336 4O1P ANP 13.1737
337 3FW9 SLX 13.1737
338 5TA6 79D 13.7725
339 3FC2 IBI 13.7725
340 5JFL NAD 13.7725
341 4XYM A12 13.7725
342 3T50 FMN 14.0625
343 3DAK ANP 14.1379
344 4Y0X ADP 14.3713
345 5MU6 MYA 14.3713
346 5MU6 KFK 14.3713
347 3TWO NDP 14.3713
348 4MO4 ACP 14.3713
349 3LOO B4P 14.3713
350 3VQ2 LP4 LP5 MYR DAO 14.5833
351 4OOE FOM 14.604
352 4OOE NDP 14.604
353 6BTN E8M 14.8515
354 2ZJ1 ARJ 14.9701
355 2ZJ1 NAD 14.9701
356 5LI1 ANP 14.9701
357 4ZUL UN1 14.9701
358 2Q37 3AL 14.9701
359 5LI9 ACP 14.9701
360 4B7X NAP 14.9701
361 5UMY TNN 15
362 2QTR NXX 15.3439
363 4C2W ANP 15.3846
364 5MW8 ATP 15.5689
365 1Q72 COC 15.6951
366 5LXM ADP 15.7895
367 3G08 FEE 16.1616
368 2PVF ACP 16.1677
369 3RI1 3RH 16.7665
370 2CYE COA 17.2932
371 5MST FUM 17.3653
372 3KAL ADP 17.9641
373 3TCT 3MI 18.1102
374 4YZN 4K5 18.5629
375 2QK4 ATP 18.5629
376 5C3R AKG 18.5629
377 5C3R HMU 18.5629
378 2WET FAD 19.1617
379 1IR3 ANP 19.1617
380 3V8S 0HD 19.1617
381 5N87 N66 19.1617
382 1F74 NAY 19.7605
383 4F9C 0SX 20.1389
384 5HQ0 LZ9 20.2381
385 1IIU RTL 20.3593
386 5EIN NAP 20.3704
387 4H3P ANP 20.8333
388 4Q5H ANP 21.0526
389 4K4D HFQ 21.1679
390 4N9I PCG 21.4286
391 5HZ9 5M8 21.4815
392 5TH5 7C5 21.5569
393 4RF7 ARG 21.5569
394 2GQS C2R 23.9521
395 2GQS ADP 23.9521
396 4F7E 0SH 24.4898
397 3SAO DBH 26.25
398 4K38 SAM 27.7778
399 5WO4 B7V 32.9341
400 4NAT 2W5 35.625
401 4NAT ADP 35.625
402 5OO5 UUA 38.7097
403 5ODT ADP 47.8261
404 5UPK ANP 48.503
Pocket No.: 2; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 3cf6.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found with APoc: 83
This union binding pocket(no: 3) in the query (biounit: 3cf6.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 4AG8 AXI 3.59281
2 6GWR FEW 4.19162
3 4L77 CNL 4.79042
4 6AMI TRP 4.79042
5 4URS C2E 5.31915
6 5HGZ MLA 5.34979
7 1Q19 SSC 5.38922
8 1D8C GLV 5.38922
9 1OFZ FUC 5.38922
10 1P7T PYR 5.38922
11 4COQ SAN 5.66802
12 3V66 D3A 5.88235
13 1RM0 NAI 5.98802
14 5WS9 OXL 5.98802
15 3KVY URA 6.14887
16 5W4W 9WG 6.34441
17 1JPA ANP 6.41026
18 1NX4 AKG 6.58683
19 4OJ8 AKG 6.58683
20 4AT0 FAD 6.66667
21 4CP8 MLI 6.98152
22 2PZI AXX 7.18563
23 4AGS GSH 7.18563
24 5WKR NAR 7.18563
25 4WOE 3S5 7.18563
26 4CRL C1I 7.18563
27 2PVN P63 7.38636
28 1UU1 PMP HSA 7.46269
29 3A76 SPD 7.78443
30 4LIK CIT 7.78443
31 4LAE 1VM 7.78443
32 4LAE NAP 7.78443
33 4IP7 FLC 7.78443
34 4Q86 AMP 7.78443
35 3E7S AT2 8.38323
36 3HQP OXL 8.98204
37 2JBH 5GP 8.98204
38 3NOJ PYR 9.2437
39 2J5V PCA 9.26431
40 2WLG SOP 9.30233
41 3ITA AIC 9.58084
42 2O3Z AI7 9.5941
43 6C0B MLI 9.61539
44 4LWM MHO 9.67742
45 2X34 UQ8 9.94475
46 2X32 OTP 10.0559
47 1DQN IMU 10.4348
48 1I1N SAH 10.6195
49 1VPM COA 10.6509
50 1BZY IMU 11.3772
51 6AR9 3L4 11.7647
52 5N53 8NB 11.976
53 5OFW 9TW 11.976
54 1T3Q MCN 12.5749
55 2XKO AKG 13.0631
56 2XHK AKG 13.0631
57 5NM7 GLY 13.7725
58 2G50 PYR 13.7725
59 2YC5 6BC 14.3713
60 4V1F BQ1 15.1163
61 3LA3 2FT 15.2263
62 3KCC CMP 17.3077
63 4NVP 7CH 17.7034
64 4AVB CMP 17.9641
65 3SHR CMP 18.3946
66 2PTM CMP 19.697
67 1NE6 SP1 19.788
68 5KBF CMP 22.9236
69 1CX4 CMP 23.2787
70 5IFK HPA 25.1497
71 3I54 CMP 26.9076
72 3OF1 CMP 27.2358
73 3I59 N6R 27.3092
74 3I59 N6S 27.3092
75 3OCP CMP 28.0576
76 5KJZ PCG 28.6667
77 5H5O PCG 30.2326
78 4OFG PCG 31.25
79 5C8W PCG 31.4685
80 5BV6 35G 34.8684
81 3PNA CMP 36.3636
82 4KU7 PCG 36.6013
83 5JAX 6J7 41.4815
Pocket No.: 4; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 3cf6.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found with APoc: 21
This union binding pocket(no: 5) in the query (biounit: 3cf6.bio2) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 3NYQ AMP 2.57426
2 4ASE AV9 3.59281
3 3MJY IJZ 3.59281
4 3MJY FMN 3.59281
5 3DHV DAL AMP 3.59281
6 6FW2 MTE 4.79042
7 4O0L NDP 4.79042
8 5DEY 59T 5.38721
9 4RVU NDP 5.42169
10 4P5Z Q7M 5.54017
11 4WHZ 3NL 5.98802
12 2HGS ADP 6.58683
13 3HMO STU 7.18563
14 2GC0 PAN 7.44681
15 3SLS ANP 7.56579
16 1TUF AZ1 7.8341
17 2ZAT NAP 8.98204
18 4Z87 GDP 8.98204
19 4WQ2 3SU 9.82659
20 5MY8 RXZ 12.5749
21 3NW7 LGV 13.1737
Pocket No.: 6; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found with APoc: 5
This union binding pocket(no: 6) in the query (biounit: 3cf6.bio2) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 4IA6 EIC 6.42978
2 6F7X MFU 8.88889
3 2BS5 BGC GAL FUC 8.88889
4 3ZW0 FUC 10.3448
5 2J73 GLC GLC GLC 12.6214
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