Receptor
PDB id Resolution Class Description Source Keywords
3AXY 2.4 Å NON-ENZYME: OTHER STRUCTURE OF FLORIGEN ACTIVATION COMPLEX CONSISTING OF RICE HD3A, 14-3-3 PROTEIN GF14 AND RICE FD HOMOLOG OSFD1 ORYZA SATIVA JAPONICA GROUP PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 14-3-3 PROTEIN BZPROTEIN FLORAL INDUCTION TRANSCRIPTIONAL ACTIVATOR SIGNAPROTEIN DNA BINDING PHOSPHORYLATION NUCLEUS SIGNALING PPROTEIN BINDING COMPLEX
Ref.: 14-3-3 PROTEINS ACT AS INTRACELLULAR RECEPTORS FOR FLORIGEN NATURE V. 476 332 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LEU GLN ARG VAL LEU SEP ALA PRO PHE E:189;
F:189;
K:189;
L:189;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
867.919 n/a [P+](...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3AXY 2.4 Å NON-ENZYME: OTHER STRUCTURE OF FLORIGEN ACTIVATION COMPLEX CONSISTING OF RICE HD3A, 14-3-3 PROTEIN GF14 AND RICE FD HOMOLOG OSFD1 ORYZA SATIVA JAPONICA GROUP PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 14-3-3 PROTEIN BZPROTEIN FLORAL INDUCTION TRANSCRIPTIONAL ACTIVATOR SIGNAPROTEIN DNA BINDING PHOSPHORYLATION NUCLEUS SIGNALING PPROTEIN BINDING COMPLEX
Ref.: 14-3-3 PROTEINS ACT AS INTRACELLULAR RECEPTORS FOR FLORIGEN NATURE V. 476 332 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LEU GLN ARG VAL LEU SEP ALA PRO PHE; Similar ligands found: 171
No: Ligand ECFP6 Tc MDL keys Tc
1 LEU GLN ARG VAL LEU SEP ALA PRO PHE 1 1
2 ARG SEP PRO VAL PHE SER 0.622378 0.943662
3 ARG ARG ALA SEP ALA PRO LEU PRO 0.58042 0.930556
4 VAL MET ALA PRO ARG THR LEU PHE LEU 0.554839 0.794872
5 ARG THR PRO SEP LEU PRO THR 0.552448 0.891892
6 ARG LEU TYR HIS SEP LEU PRO ALA 0.54717 0.860759
7 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.540373 0.729412
8 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.526316 0.835616
9 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.525974 0.851351
10 ARG PHE PRO LEU THR PHE GLY TRP 0.520958 0.7625
11 ASP ARG VAL TYR ILE HIS PRO PHE 0.511765 0.731707
12 GLN ARG SER THR SEP THR PRO ASN VAL HIS 0.506494 0.866667
13 LEU PRO PHE GLU ARG ALA THR VAL MET 0.506024 0.772152
14 ARG THR PRO SEP LEU PRO THR 49F 0.503106 0.835443
15 ARG TYR PRO LEU THR PHE GLY TRP 0.50289 0.743902
16 ARG SER HIS SEP SER PRO ALA SER LEU GLN 0.5 0.87013
17 ARG VAL ALA SEP PRO THR SER GLY VAL 0.496774 0.891892
18 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.496732 0.783784
19 PHE ASN ARG PRO VAL 0.496454 0.808219
20 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.494048 0.766234
21 DPN PRO ARG 0.492188 0.771429
22 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.49162 0.765432
23 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.490798 0.776316
24 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.487013 0.943662
25 ARG SER ALA SEP GLU PRO SER LEU 0.484076 0.905405
26 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.483696 0.746988
27 LYS PRO VAL LEU ARG THR ALA 0.482993 0.797297
28 TRP MET ASP PHE ASP ASP ASP ILE PRO PHE 0.481203 0.694444
29 TRP ASP ILE PRO PHE 0.481203 0.694444
30 SER SER PHE TYR PRO SEP ALA GLU GLY 0.480519 0.75641
31 DPN PRO DAR ILE NH2 0.478261 0.788732
32 DPN PRO DAR DTH NH2 0.478261 0.791667
33 ACE ARG THR PRO SEP LEU PRO THR 60H 0.47561 0.907895
34 ACE ARG THR PRO SEP LEU PRO THR PIP 0.474026 0.894737
35 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.471591 0.848101
36 ALA MET ALA PRO ARG THR LEU LEU LEU 0.470199 0.769231
37 VAL PRO LEU ARG PRO MET THR TYR 0.469136 0.765432
38 LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.46875 0.666667
39 LEU LEU PHE GLY TYR PRO VAL TYR VAL 0.46875 0.666667
40 PHE ALA PRO GLY PHE PHE PRO TYR LEU 0.467949 0.683544
41 ARG PRO MET THR PHE LYS GLY ALA LEU 0.467836 0.78481
42 DHI PRO PHE HIS LEU LEU VAL TYR 0.467456 0.65
43 LYS PRO PHE PTR VAL ASN VAL GLU PHE 0.467066 0.75
44 ARG THR TYR SEP GLY PRO MET ASN LYS VAL 0.467033 0.831325
45 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.463855 0.675325
46 LEU LEU PHE GLY LYS PRO VAL TYR VAL 0.463415 0.658228
47 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.463087 0.773333
48 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.462428 0.772152
49 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.462025 0.7625
50 TYR LEU ALA PRO GLY PRO VAL THR ALA 0.461039 0.717949
51 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.461039 0.797297
52 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.458824 0.743902
53 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.458599 0.753247
54 LEU PRO PHE ASP ARG THR THR ILE MET 0.458333 0.775
55 LEU SER SER PRO VAL THR LYS SER PHE 0.458065 0.756757
56 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.457627 0.756098
57 TYR MET ASP PHE ASP ASP ASP ILE PRO PHE 0.456693 0.676056
58 DPN PRO DAR CYS NH2 0.456522 0.746479
59 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.455696 0.766234
60 LYS PRO ILE VAL VAL LEU HIS GLY TYR 0.455621 0.654321
61 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.45509 0.703704
62 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.454545 0.763158
63 LEU PRO PHE GLU ARG ALA THR ILE MET 0.454023 0.7625
64 VAL ORN LEU DPN PRO VAL ORN LEU DPN PRO 0.453947 0.675676
65 ARG PRO GLY ASN PHE LEU GLN SER SER PRO 0.453488 0.815789
66 LYS PRO PHE PTR VAL ASN VAL NH2 0.453416 0.7375
67 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.451613 0.769231
68 ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 0.450292 0.815789
69 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.449438 0.769231
70 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.448485 0.647059
71 ALA ARG SER HIS SEP TYR PRO ALA 0.447059 0.825
72 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.445087 0.740741
73 ARG VAL ALA SER PRO THR SER GLY VAL 0.444444 0.810811
74 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.444444 0.717949
75 ASN ARG PRO ILE LEU SER LEU 0.443709 0.813333
76 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.443182 0.7875
77 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.443114 0.813333
78 LEU PHE GLY TYR PRO VAL TYR VAL 0.443038 0.666667
79 TYR PRO LYS ARG ILE ALA 0.442308 0.753247
80 ACE PRO ALA PRO PHE 0.442029 0.684932
81 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.441718 0.776316
82 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.440678 0.782051
83 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.440476 0.675325
84 PHE PRO THR LYS ASP VAL ALA LEU 0.440252 0.72
85 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.440252 0.794872
86 PHE ALA PRO GLY ASN TYR PRO ALA LEU 0.439024 0.691358
87 SER ASP ILE LEU PHE PRO ALA ASP SER 0.43871 0.756757
88 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.437909 0.727273
89 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.4375 0.628205
90 PHE PRO ARG 0.43609 0.742857
91 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.435897 0.644737
92 ARG PRO LYS ARG ILE ALA 0.435374 0.791667
93 TYR SEP PRO THR SEP PRO SER 0.435374 0.779221
94 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.435028 0.753086
95 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.435028 0.753086
96 GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS 0.434783 0.75
97 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.434555 0.73494
98 LEU PRO PHE GLU LYS SER THR VAL MET 0.434524 0.708861
99 TYR LEU GLU PRO ALA PRO VAL THR ALA 0.433121 0.705128
100 ALA CYS SEP PRO GLN PHE GLY 0.433121 0.821918
101 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.432749 0.662651
102 PHE ALA PRO GLY ASN TYI PRO ALA LEU 0.431138 0.651163
103 PTR LEU ARG VAL ALA 0.430556 0.743243
104 ARG PRO MET THR TYR LYS GLY ALA LEU 0.429379 0.756098
105 SER THR SEP PRO THR PHE ASN LYS 0.428571 0.802632
106 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.427711 0.773333
107 PTR VAL PRO MET LEU 0.427632 0.75641
108 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.426752 0.753247
109 LYS PRO SEP GLN GLU LEU 0.426573 0.873239
110 ALA DAL PRO PHE NIT 0.426573 0.641975
111 CYS THR PRO SER ARG 0.426573 0.783784
112 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.426035 0.65
113 ARG ARG LEU ILE PHE NH2 0.425532 0.647887
114 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.424242 0.64557
115 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.424242 0.789474
116 LYS LEU THR PRO LEU CYS VAL THR LEU 0.423841 0.706667
117 ARG ALA HIS SEP SER PRO ALA SER LEU GLN 0.423313 0.828947
118 ARG GLN ALA SEP LEU SER ILE SER VAL 0.423077 0.743243
119 PRO LYS ARG PRO THR THR LEU ASN LEU PHE 0.422857 0.792208
120 SER PRO LYS ARG ILE ALA 0.422819 0.808219
121 ARG ARG GLN ARG SEP ALA PRO 0.422535 0.835616
122 ILE SER PRO ARG THR LEU ASP ALA TRP 0.421622 0.7875
123 GLN ALA SER TPO PRO ARG NIT 0.421053 0.785714
124 SER HIS SEP SER PRO ALA SER LEU GLN 0.421053 0.818182
125 ARG PRO LYS PRO LEU VAL ASP PRO 0.42069 0.777778
126 ARG TYR GLY PHE VAL ALA ASN PHE 0.420382 0.6
127 GLY PHE ARG PRO 0.42029 0.774648
128 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.419355 0.833333
129 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.418079 0.828947
130 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.417112 0.722892
131 MET VAL TRP GLY PRO ASP PRO LEU TYR VAL 0.416216 0.635294
132 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.416185 0.658537
133 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.415663 0.712329
134 DTY ILE ARG LEU LPD 0.415584 0.763158
135 TYR LEU GLY GLY PRO ASP PHE PRO THR ILE 0.414773 0.679012
136 ARG PRO GLY ASN PHE LEU GLN SER ARG LEU 0.414773 0.84
137 TYR LEU GLU PRO GLY PRO VAL THR ALA 0.414634 0.705128
138 GLU ASP GLU ASP PHE GLU ILE LEU SEP LEU 0.414634 0.694444
139 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.413043 0.789474
140 SER TYR SEP PRO THR SEP PRO SEP TYR SER 0.412903 0.753247
141 SER ALA PRO ASP THR ARG PRO ALA 0.412903 0.789474
142 LYS VAL LEU PHE LEU ASP GLY 0.412587 0.605634
143 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.4125 0.797297
144 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.409836 0.710843
145 ILE PRO ALA TYR GLY VAL LEU THR ILE 0.409639 0.692308
146 TYR HIS SEP VAL VAL ARG TYR ALA 0.409639 0.75
147 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.408805 0.61039
148 TYR LEU GLU PRO GLY PRO VAL THR VAL 0.408537 0.705128
149 LYS MET ASP SEP PHE LEU ASP MET GLN LEU 0.407407 0.688312
150 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.407186 0.6
151 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.405714 0.6625
152 GLY SER ASP PRO PHE LYS 0.405405 0.702703
153 ILE THR ASP GLN VAL PRO PHE SER VAL 0.404762 0.76
154 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.404624 0.654762
155 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.403509 0.65
156 LEU PRO PHE ASP LYS THR THR ILE MET 0.403509 0.675
157 THR PRO PRO SER PRO PHE 0.402778 0.716216
158 SER SER GLY LYS VAL PRO LEU SER 0.402685 0.72973
159 SIN ALA ALA PRO PHE NIT 0.402597 0.658537
160 ARG ABA VAL ILE PHE ALA ASN ILE 0.402597 0.648649
161 LEU ASN PHE PRO ILE SER PRO 0.402597 0.74026
162 GLN ASN GLY PTR VAL ASN PRO THR TYR 0.402439 0.7625
163 THR LYS PRO ARG 0.401515 0.732394
164 ASN LEU VAL PRO GLN VAL ALA THR VAL 0.401274 0.706667
165 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.401163 0.815789
166 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.40113 0.675
167 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.40113 0.7875
168 GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.4 0.697368
169 ASN LEU VAL PRO MET VAL ALA VAL VAL 0.4 0.671053
170 ALA THR PRO PHE GLN GLU 0.4 0.694444
171 ASN LEU VAL PRO MET VAL ALA ALA VAL 0.4 0.671053
Similar Binding Sites (Proteins are less than 50% similar to leader)
Feedback