Receptor
PDB id Resolution Class Description Source Keywords
3AXY 2.4 Å NON-ENZYME: OTHER STRUCTURE OF FLORIGEN ACTIVATION COMPLEX CONSISTING OF RICE HD3A, 14-3-3 PROTEIN GF14 AND RICE FD HOMOLOG OSFD1 ORYZA SATIVA JAPONICA GROUP PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 14-3-3 PROTEIN BZPROTEIN FLORAL INDUCTION TRANSCRIPTIONAL ACTIVATOR SIGNAPROTEIN DNA BINDING PHOSPHORYLATION NUCLEUS SIGNALING PPROTEIN BINDING COMPLEX
Ref.: 14-3-3 PROTEINS ACT AS INTRACELLULAR RECEPTORS FOR FLORIGEN NATURE V. 476 332 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LEU GLN ARG VAL LEU SEP ALA PRO PHE E:189;
F:189;
K:189;
L:189;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
867.919 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3AXY 2.4 Å NON-ENZYME: OTHER STRUCTURE OF FLORIGEN ACTIVATION COMPLEX CONSISTING OF RICE HD3A, 14-3-3 PROTEIN GF14 AND RICE FD HOMOLOG OSFD1 ORYZA SATIVA JAPONICA GROUP PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 14-3-3 PROTEIN BZPROTEIN FLORAL INDUCTION TRANSCRIPTIONAL ACTIVATOR SIGNAPROTEIN DNA BINDING PHOSPHORYLATION NUCLEUS SIGNALING PPROTEIN BINDING COMPLEX
Ref.: 14-3-3 PROTEINS ACT AS INTRACELLULAR RECEPTORS FOR FLORIGEN NATURE V. 476 332 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LEU GLN ARG VAL LEU SEP ALA PRO PHE; Similar ligands found: 167
No: Ligand ECFP6 Tc MDL keys Tc
1 LEU GLN ARG VAL LEU SEP ALA PRO PHE 1 1
2 ARG SEP PRO VAL PHE SER 0.606897 0.943662
3 ARG ARG ALA SEP ALA PRO LEU PRO 0.576389 0.930556
4 VAL MET ALA PRO ARG THR LEU PHE LEU 0.557692 0.794872
5 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.549669 0.835616
6 ARG THR PRO SEP LEU PRO THR 0.545455 0.891892
7 ALA PHE ARG ILE PRO LEU THR ARG 0.535948 0.826667
8 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.530488 0.729412
9 ARG THR PHE SER PRO THR TYR GLY LEU 0.528302 0.797468
10 ARG LEU TYR HIS SEP LEU PRO ALA 0.527607 0.860759
11 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.522581 0.851351
12 ARG PHE PRO LEU THR PHE GLY TRP 0.514793 0.7625
13 DPN PRO ARG 0.503876 0.771429
14 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.5 0.943662
15 ARG VAL ALA SEP PRO THR SER GLY VAL 0.496774 0.891892
16 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.496644 0.819444
17 ALA MET ALA PRO ARG THR LEU LEU LEU 0.496644 0.769231
18 ARG TYR PRO LEU THR PHE GLY TRP 0.494318 0.743902
19 ARG THR PRO SEP LEU PRO GLY D4K 0.494186 0.85
20 LEU PRO PHE GLU ARG ALA THR VAL MET 0.494048 0.772152
21 GLN ARG SER THR SEP THR PRO ASN VAL HIS 0.49359 0.866667
22 PHE ASN ARG PRO VAL 0.493056 0.808219
23 TRP ASP ILE PRO PHE 0.492424 0.722222
24 TRP MET ASP PHE ASP ASP ASP ILE PRO PHE 0.492424 0.722222
25 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.490446 0.821918
26 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.490196 0.808219
27 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.487654 0.776316
28 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.486188 0.765432
29 TYR MET ASP PHE ASP ASP ASP ILE PRO PHE 0.483871 0.704225
30 DPN PRO DAR DTH NH2 0.482014 0.780822
31 DPN PRO DAR ILE NH2 0.482014 0.788732
32 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.480519 0.797297
33 LYS PRO VAL LEU ARG THR ALA 0.48 0.797297
34 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.48 0.848101
35 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.478495 0.746988
36 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.47651 0.773333
37 VAL PRO LEU ARG PRO MET THR TYR 0.475309 0.765432
38 ACE ARG THR PRO SEP LEU PRO THR PIP 0.474026 0.894737
39 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.473988 0.766234
40 ARG PRO MET THR PHE LYS GLY ALA LEU 0.471264 0.78481
41 DPN PRO DAR CYS NH2 0.471014 0.736111
42 ACE PRO ALA PRO PHE 0.46875 0.684932
43 ARG GLY PRO GLY CYS ALA PHE VAL THR ILE 0.467836 0.815789
44 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.464968 0.753247
45 LEU LEU PHE GLY LYS PRO VAL TYR VAL 0.462963 0.6625
46 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.462428 0.772152
47 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.459119 0.766234
48 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.458333 0.688312
49 ARG THR TYR SEP GLY PRO MET ASN LYS VAL 0.456522 0.831325
50 LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.45625 0.679487
51 LEU LEU PHE GLY TYR PRO VAL TYR VAL 0.45625 0.679487
52 PRO LYS ARG PRO THR THR LEU ASN LEU PHE 0.454023 0.792208
53 ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 0.453488 0.802632
54 LYS PRO PHE PTR VAL ASN VAL NH2 0.453416 0.75
55 ASN ARG PRO ILE LEU SER LEU 0.453333 0.813333
56 LYS PRO PHE PTR VAL ASN VAL GLU PHE 0.452941 0.7625
57 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.448718 0.7625
58 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.448485 0.773333
59 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.447674 0.743902
60 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.447514 0.769231
61 VAL ORN LEU DPN PRO VAL ORN LEU DPN PRO 0.447368 0.702703
62 LEU PRO PHE ASP ARG THR THR ILE MET 0.447059 0.775
63 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.446809 0.769231
64 TYR PRO LYS ARG ILE ALA 0.44586 0.753247
65 LEU PRO PHE GLU ARG ALA THR ILE MET 0.445714 0.7625
66 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.445122 0.776316
67 ARG VAL ALA SER PRO THR SER GLY VAL 0.444444 0.810811
68 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.443787 0.813333
69 CYS THR PRO SER ARG 0.443662 0.783784
70 ALA DAL PRO PHE NIT 0.442857 0.654321
71 TYR LEU ALA PRO GLY PRO VAL THR ALA 0.442308 0.730769
72 ALA ARG SER HIS SEP TYR PRO ALA 0.44186 0.825
73 LYS PRO ILE VAL VAL LEU HIS GLY TYR 0.44186 0.666667
74 ACE ARG THR PRO SEP LEU PRO GLY D3Q 0.44086 0.8625
75 HIS PRO PHE 0.440298 0.64
76 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.44 0.740741
77 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.43956 0.756098
78 ACE ARG THR PRO SEP LEU PRO GLY D3W 0.43956 0.851852
79 SER ASP ILE LEU PHE PRO ALA ASP SER 0.43871 0.77027
80 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.436709 0.644737
81 ACE ARG THR PRO SEP LEU PRO GLY D4H 0.436464 0.896104
82 MET CYS PRO ARG MET THR ALA VAL MET 0.435583 0.769231
83 DHI PRO PHE HIS LEU LEU VAL TYR 0.435294 0.6625
84 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.435294 0.688312
85 ARG PRO LYS ARG ILE ALA 0.433333 0.791667
86 ALA CYS SEP PRO GLN PHE GLY 0.433121 0.821918
87 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.432584 0.743902
88 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.432258 0.833333
89 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.431953 0.763158
90 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.431373 0.824324
91 LYS PRO SEP GLN GLU LEU 0.429577 0.873239
92 ARG GLN ALA SEP LEU SER ILE SER VAL 0.429487 0.743243
93 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.429412 0.815789
94 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.429412 0.716049
95 ARG PRO GLY ASN PHE LEU GLN SER ARG LEU 0.429379 0.826667
96 ARG ARG LEU ILE PHE NH2 0.428571 0.647887
97 ARG PRO MET THR TYR LYS GLY ALA LEU 0.427778 0.756098
98 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.427778 0.753086
99 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.427746 0.717949
100 LEU PRO SER PHE GLU THR ALA LEU 0.427673 0.77027
101 LEU PHE GLY TYR PRO VAL TYR VAL 0.427673 0.679487
102 PTR LEU ARG VAL ALA 0.427586 0.743243
103 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.426966 0.8
104 PHE PRO THR LYS ASP VAL ALA LEU 0.426829 0.746667
105 PHE PRO ARG 0.426471 0.742857
106 SER ALA PRO ASP THR ARG PRO ALA 0.425806 0.789474
107 GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS 0.425532 0.75
108 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.42515 0.647059
109 THR PRO PRO SER PRO PHE 0.42446 0.72973
110 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.423529 0.662651
111 0G6 0.423358 0.72
112 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.42268 0.73494
113 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.42236 0.75
114 ILE GLY PRO GLY ARG ALA PHE TYR VAL 0.421965 0.746835
115 ILE SER PRO ARG THR LEU ASP ALA TRP 0.421622 0.7875
116 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.421384 0.797297
117 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.421384 0.74359
118 GLN ALA SER TPO PRO ARG NIT 0.421053 0.785714
119 PTR VAL PRO MET LEU 0.421053 0.769231
120 ILE PRO ALA TYR GLY VAL LEU THR ILE 0.420732 0.705128
121 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.420382 0.74026
122 PHE ALA PRO GLY ASN TYR PRO ALA LEU 0.419162 0.691358
123 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.418478 0.710843
124 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.418478 0.782051
125 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.418079 0.828947
126 GLY PHE ARG PRO 0.417266 0.774648
127 LEU ASN PHE PRO ILE SER PRO 0.417219 0.74026
128 ARG ALA HIS SEP SER PRO ALA SER LEU GLN 0.417178 0.842105
129 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.417178 0.628205
130 TYR SEP PRO THR SEP PRO SER 0.416107 0.792208
131 ACE ARG THR PRO SEP LEU PRO GLY D3K 0.415789 0.821429
132 SER THR SEP PRO THR PHE ASN LYS 0.415205 0.802632
133 ARG TYR GLY PHE VAL ALA ASN PHE 0.415094 0.6
134 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.4125 0.61039
135 TYR LEU GLU PRO ALA PRO VAL THR ALA 0.4125 0.717949
136 SER PRO LYS ARG ILE ALA 0.412162 0.794521
137 ASN LEU VAL PRO MET VAL ALA ALA VAL 0.411765 0.662338
138 ASN LEU VAL PRO MET VAL ALA VAL VAL 0.411765 0.662338
139 PHE ALA PRO GLY ASN TYI PRO ALA LEU 0.411765 0.651163
140 ALA ARG MLZ SER ALA PRO ALA THR 0.411392 0.792208
141 LEU SER SER PRO VAL THR LYS SER PHE 0.411043 0.756757
142 1IP CYS PHE SER LYS PRO ARG 0.410714 0.802632
143 ALA THR PRO PHE GLN GLU 0.410448 0.708333
144 ASN LEU VAL PRO GLN VAL ALA THR VAL 0.410256 0.706667
145 TYR LEU GLY GLY PRO ASP PHE PRO THR ILE 0.409091 0.691358
146 GLU ASP GLU ASP PHE GLU ILE LEU SEP LEU 0.408537 0.708333
147 ALA ASN SER ARG HIS PRO THR SER ILE ILE 0.408537 0.782051
148 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.407895 0.767123
149 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.407216 0.722892
150 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.407186 0.658228
151 LEU PRO PHE GLU LYS SER THR VAL MET 0.406977 0.721519
152 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.40678 0.7875
153 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.406417 0.789474
154 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.405882 0.813333
155 ILE GLY PRO GLY ARG ALA PHE TYR THR 0.405714 0.746835
156 ARG PRO LYS PRO LEU VAL ASP PRO 0.405405 0.777778
157 ASN LEU VAL PRO SER VAL ALA THR VAL 0.405229 0.733333
158 SER HIS PRO ARG PRO ILE ARG VAL 0.403614 0.805195
159 DTY ILE ARG LEU LPD 0.402597 0.763158
160 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.402367 0.6
161 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.402367 0.726027
162 SER TYR SEP PRO THR SEP PRO SEP TYR SER 0.401274 0.766234
163 GLU ARG GLU SEP GLU PHE ASP ILE GLU ASP 0.401198 0.780822
164 ARG ALA ILE SEP LEU PRO 0.4 0.859155
165 LYS LEU THR PRO LEU CYS VAL THR LEU 0.4 0.72
166 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.4 0.6625
167 ALA PRO SER PTR VAL ASN VAL GLN ASN 0.4 0.820513
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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