Receptor
PDB id Resolution Class Description Source Keywords
2yc0 2.15 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLU HOMO SAPIENS OXIDOREDUCTASE DIOXYGENASE METAL-BINDING TRANSCRIPTION HLOOP-HELIX-BETA DSBH FACIAL TRIAD ASPARAGINYL/ASPARTYL HYDROXYLASE TRANSCRIPTION AND EPIGENETIC REGULATION SIGNADEVELOPMENT CELL STRUCTURE ANKYRIN REPEAT DOMAIN ARD BEHYDROXYLATION TRANSCRIPTION ACTIVATOR/INHIBITOR PHOSPHORYS-NITROSYLATION
Ref.: THE ONCOMETABOLITE 2-HYDROXYGLUTARATE INHIBITS HISTONE LYSINE DEMETHYLASES. EMBO REP. V. 12 463 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data Chemaxon Viewer Molecular Weight (Da) Formula SMILES
2HG A:601;
Valid;
none;
ic50 = 1500 uM 148.114 C5 H8 O5 C(CC(...
FE2 A:501;
Part of Protein;
none;
submit data 55.845 Fe [Fe+2...
GOL A:602;
A:603;
A:604;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data 92.094 C3 H8 O3 C(C(C...
SO4 A:901;
A:902;
A:904;
A:905;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data 96.063 O4 S [O-]S...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WA4 2.5 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA WITH N,3-DIHYDROXYBENZAMIDE HOMO SAPIENS HYDROXYLASE DIOXYGENASE TRANSCRIPTION OXIDOREDUCTASE TRANSCRIPTION ACTIVATOR/INHIBITOR HYPOXIA
Ref.: STRUCTURAL BASIS FOR BINDING OF CYCLIC 2-OXOGLUTARATE ANALOGUES TO FACTOR-INHIBITING HYPOXIA-INDUCIBLE FACTOR. BIOORG.MED.CHEM.LETT. V. 20 6125 2010
Members (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2W0X ic50 = 625 uM PD2 C7 H5 N O4 c1cnc(cc1C....
2 1MZF - AKG C5 H6 O5 O=C([O-])C....
3 2WA3 ic50 = 1 mM A29 C8 H6 O4 c1cc(cc(c1....
4 2CGN - SIN C4 H6 O4 O=C([O-])C....
5 2WA4 ic50 = 18 uM 069 C7 H7 N O3 c1cc(cc(c1....
6 4AI8 ic50 > 100 uM DZA C6 H12 N2 O3 CN(C)NC(=O....
7 1MZE - TAR C4 H6 O6 O=C([O-])C....
8 2YDE ic50 = 189 uM S2G C5 H8 O5 C(CC(=O)O)....
9 2YC0 ic50 = 1500 uM 2HG C5 H8 O5 C(CC(=O)O)....