Receptor
PDB id Resolution Class Description Source Keywords
2yc0 2.15 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLU HOMO SAPIENS OXIDOREDUCTASE DIOXYGENASE METAL-BINDING TRANSCRIPTION HLOOP-HELIX-BETA DSBH FACIAL TRIAD ASPARAGINYL/ASPARTYL HYDROXYLASE TRANSCRIPTION AND EPIGENETIC REGULATION SIGNADEVELOPMENT CELL STRUCTURE ANKYRIN REPEAT DOMAIN ARD BEHYDROXYLATION TRANSCRIPTION ACTIVATOR/INHIBITOR PHOSPHORYS-NITROSYLATION
Ref.: THE ONCOMETABOLITE 2-HYDROXYGLUTARATE INHIBITS HISTONE LYSINE DEMETHYLASES. EMBO REP. V. 12 463 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
2HG A:601;
Valid;
none;
ic50 = 1500 uM
148.114 C5 H8 O5 C(CC(...
FE2 A:501;
Part of Protein;
none;
submit data
55.845 Fe [Fe+2...
GOL A:602;
A:603;
A:604;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SO4 A:901;
A:902;
A:904;
A:905;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WA4 2.5 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA WITH N,3-DIHYDROXYBENZAMIDE HOMO SAPIENS HYDROXYLASE DIOXYGENASE TRANSCRIPTION OXIDOREDUCTASE TRANSCRIPTION ACTIVATOR/INHIBITOR HYPOXIA
Ref.: STRUCTURAL BASIS FOR BINDING OF CYCLIC 2-OXOGLUTARATE ANALOGUES TO FACTOR-INHIBITING HYPOXIA-INDUCIBLE FACTOR. BIOORG.MED.CHEM.LETT. V. 20 6125 2010
Members (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2W0X ic50 = 625 uM PD2 C7 H5 N O4 c1cnc(cc1C....
2 1MZF - AKG C5 H6 O5 C(CC(=O)O)....
3 2WA3 ic50 = 1 mM A29 C8 H6 O4 c1cc(cc(c1....
4 2CGN - SIN C4 H6 O4 C(CC(=O)O)....
5 2WA4 ic50 = 18 uM 069 C7 H7 N O3 c1cc(cc(c1....
6 4AI8 ic50 > 100 uM DZA C6 H12 N2 O3 CN(C)NC(=O....
7 1MZE - TAR C4 H6 O6 [C@H]([C@@....
8 2YDE ic50 = 189 uM S2G C5 H8 O5 C(CC(=O)O)....
9 2YC0 ic50 = 1500 uM 2HG C5 H8 O5 C(CC(=O)O)....
70% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2W0X ic50 = 625 uM PD2 C7 H5 N O4 c1cnc(cc1C....
2 1MZF - AKG C5 H6 O5 C(CC(=O)O)....
3 2WA3 ic50 = 1 mM A29 C8 H6 O4 c1cc(cc(c1....
4 2CGN - SIN C4 H6 O4 C(CC(=O)O)....
5 2WA4 ic50 = 18 uM 069 C7 H7 N O3 c1cc(cc(c1....
6 4AI8 ic50 > 100 uM DZA C6 H12 N2 O3 CN(C)NC(=O....
7 1MZE - TAR C4 H6 O6 [C@H]([C@@....
8 2YDE ic50 = 189 uM S2G C5 H8 O5 C(CC(=O)O)....
9 2YC0 ic50 = 1500 uM 2HG C5 H8 O5 C(CC(=O)O)....
50% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2W0X ic50 = 625 uM PD2 C7 H5 N O4 c1cnc(cc1C....
2 1MZF - AKG C5 H6 O5 C(CC(=O)O)....
3 2WA3 ic50 = 1 mM A29 C8 H6 O4 c1cc(cc(c1....
4 2CGN - SIN C4 H6 O4 C(CC(=O)O)....
5 2WA4 ic50 = 18 uM 069 C7 H7 N O3 c1cc(cc(c1....
6 4AI8 ic50 > 100 uM DZA C6 H12 N2 O3 CN(C)NC(=O....
7 1MZE - TAR C4 H6 O6 [C@H]([C@@....
8 2YDE ic50 = 189 uM S2G C5 H8 O5 C(CC(=O)O)....
9 2YC0 ic50 = 1500 uM 2HG C5 H8 O5 C(CC(=O)O)....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 2HG; Similar ligands found: 12
No: Ligand ECFP6 Tc MDL keys Tc
1 2HG 1 1
2 S2G 1 1
3 DMR 0.461538 0.809524
4 MLT 0.461538 0.809524
5 LMR 0.461538 0.809524
6 2RH 0.444444 0.652174
7 DGY 0.44 0.666667
8 GGL 0.433333 0.653846
9 DGL 0.433333 0.653846
10 GLU 0.433333 0.653846
11 HOC 0.411765 0.62963
12 HCT 0.40625 0.8
Similar Binding Sites
Pocket no: 1; Query (leader) PDB : 2WA4; Ligand: 069; Similar sites found: 849
This union binding pocket (no: 1) in the query (biounit: 2wa4.bio1) has 18 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 2WA4 069 8.872e-20 1
2 3P3N AKG 1.332e-15 0.73427
3 2Y0I AKG 1.776e-15 0.73183
4 1H2M OGA 2.776e-15 0.7269
5 2XUM OGA 2.776e-15 0.72687
6 1H2K OGA 3.22e-15 0.7253
7 4B7E OGA 2.82e-14 0.72045
8 3D8C AKG 8.105e-15 0.68564
9 1UNB AKG 4.012e-08 0.62586
10 3NNF AKG 1.068e-06 0.4719
11 1BUC FAD 0.0004909 0.46973
12 3NKT 1HN 0.0001812 0.46777
13 4Q0P 0MK 0.008519 0.46101
14 1X09 IPE 0.001461 0.45591
15 1RM0 NAI 0.001448 0.45421
16 9LDB NAD 0.0005065 0.45025
17 9LDB OXM 0.0005824 0.44787
18 4AXD ANP 0.0009295 0.44732
19 3KT7 AKG 1.821e-06 0.44573
20 4CCO OGA 1.343e-06 0.44539
21 1Q0H FOM 0.002191 0.44471
22 4LIT AKG 8.927e-07 0.44469
23 4CCN OGA 1.924e-06 0.44289
24 2XK9 XK9 0.000745 0.44028
25 1SB8 NAD 0.003729 0.43778
26 4FR3 0V4 0.00186 0.43775
27 3AXB FAD 0.002449 0.43753
28 1E7S NAP 0.001228 0.43671
29 3IIS PID 0.007111 0.43636
30 2CSN CKI 0.0007982 0.43548
31 1T26 GBD 0.01185 0.43514
32 1NX4 AKG 7.982e-06 0.43473
33 4NTD FAD 0.002242 0.43446
34 4LH5 LF0 0.005038 0.43396
35 2WQP WQP 0.001119 0.43342
36 1OIK AKG 9.339e-05 0.43143
37 1FIQ MTE 0.002216 0.43082
38 2YGO PCF 0.0009714 0.43029
39 3GE7 AFQ 0.001688 0.42972
40 2F01 BTQ 0.01291 0.42917
41 1D6H COA 0.004419 0.42903
42 3Q9T FAY 0.003129 0.42859
43 2IZZ NAD 0.001511 0.42836
44 3WBF API 0.002759 0.42831
45 1O9D GLN 0.001587 0.42753
46 3RO7 TDR 0.001618 0.4272
47 2NX1 RP5 0.001531 0.42642
48 1LCP PLU 0.003937 0.42571
49 1P4C FMN 0.009036 0.42549
50 4BJZ FAD 0.0102 0.42472
51 2P8B NSK 0.02653 0.42464
52 3UXL CFI 0.004193 0.4246
53 4JTA NAP 0.01558 0.42438
54 1IYE PGU 0.00952 0.42375
55 1YBH FAD 0.01939 0.42342
56 3ZV6 NAD 0.005789 0.42316
57 4GLJ RHB 0.005496 0.42306
58 4NDA NIY 0.001186 0.42293
59 4CS4 ANP 0.005278 0.42272
60 1EP2 FMN 0.002616 0.42225
61 3IPQ 965 0.002873 0.42214
62 2UZ2 BTN 0.001028 0.42077
63 2NXW TPP 0.00431 0.42051
64 2ZX7 ZX7 0.002713 0.42008
65 2CKM AA7 0.00698 0.41979
66 2EWM NAD 0.00279 0.41961
67 2JF9 OHT 0.001473 0.41939
68 4UAL 3FV 0.001508 0.419
69 2F3R G5P 0.009477 0.41892
70 3TI8 LNV 0.006583 0.41878
71 2XZ3 MAL 0.002197 0.4186
72 2VQ5 LDP 0.0003811 0.41845
73 1C3V NDP 0.002735 0.41834
74 2IMP NAI 0.02155 0.4181
75 3JYN NDP 0.00432 0.41789
76 1Y9Q MED 5.064e-05 0.41759
77 2Q28 ADP 0.001651 0.41753
78 1KDK DHT 0.00189 0.41734
79 2P2V CSF 0.01292 0.41729
80 1REO FAD 0.005961 0.41722
81 4MP8 MLI 0.00523 0.41713
82 2Q2V NAD 0.00458 0.41688
83 3IBH GSH 0.001133 0.4168
84 1X54 4AD 0.002208 0.41668
85 3IOI 1GW 0.005031 0.41655
86 1WVG CXY 0.001753 0.41654
87 2YFT DQR 0.0004594 0.41654
88 2DTX BMA 0.004774 0.41616
89 4E1N TQX 0.01815 0.4159
90 4NVP 7CH 0.006135 0.41554
91 4KQI NIO 0.003254 0.41541
92 1NUS APC 0.004252 0.41541
93 3GM5 CIT 3.258e-05 0.4153
94 4GZP G39 0.007096 0.41527
95 3PFG TLO 0.007672 0.41498
96 4NE2 ADP 0.006902 0.41463
97 4BG1 OGA 0.001309 0.41449
98 1Z45 NAD 0.0035 0.41418
99 2YBQ UP2 0.006198 0.41416
100 3K37 BCZ 0.00854 0.41413
101 4QCK ASD 0.002065 0.41387
102 2IXB NAD 0.005502 0.4137
103 3HB5 E2B 0.01662 0.41336
104 4IVG ANP 0.00249 0.4128
105 4C58 824 0.001261 0.41255
106 1BGQ RDC 0.003906 0.41232
107 3FXU TSU 0.007874 0.41231
108 1UXG FUM 0.008983 0.41217
109 2V7T SAH 0.003289 0.41187
110 1IIM TTP 0.04055 0.41174
111 1K97 CIR 0.03366 0.41155
112 3K7M FAD 0.01635 0.41137
113 3TN7 NJP 0.005833 0.41135
114 1OGZ EQU 0.001855 0.41127
115 2QTR NXX 0.004582 0.41118
116 2CJE DUN 0.002143 0.41116
117 4OB6 S2T 0.005032 0.41108
118 2PTZ PAH 0.001008 0.4109
119 3GX0 GDS 0.001421 0.41066
120 3OND NAD 0.01356 0.4106
121 4PNI KQQ 0.003932 0.41059
122 1FMC CHO 0.007636 0.4105
123 4KS1 2H8 0.01093 0.40972
124 1LTH NAD 0.02958 0.40967
125 2Q1S NAI 0.01171 0.40948
126 1MVN PCO 0.01705 0.40939
127 1V35 NAI 0.0127 0.409
128 4G87 UD1 0.009237 0.40892
129 2HXT EHM 0.001129 0.4089
130 3MPI FAD 0.03282 0.40881
131 3I3X U22 0.0188 0.40877
132 2AQJ FAD 0.009637 0.40874
133 1RHC F42 0.0058 0.40865
134 1M83 ATP 0.01034 0.40859
135 4OJ8 2TQ 0.002224 0.40836
136 1HDR NAD 0.006012 0.40804
137 1HV9 UD1 0.009843 0.4078
138 2J8Z NAP 0.004701 0.40758
139 1XLI GLT 0.002736 0.4072
140 1GEX PLP 0.003108 0.40719
141 1R37 NAD 0.006877 0.40715
142 4N02 FNR 0.01896 0.40701
143 4P53 NAI 0.004915 0.40684
144 1Y52 BTN 0.002453 0.40678
145 2D37 FMN 0.005984 0.40665
146 2D0V PQQ 0.002844 0.40657
147 4LSJ LSJ 0.004599 0.40627
148 2YVF FAD 0.0272 0.40622
149 1H6W SER 0.0165 0.40612
150 4NES UD1 0.002239 0.40593
151 1QF5 GDP 0.01879 0.40551
152 2E2R 2OH 0.007576 0.40549
153 1FP2 HMO 0.004828 0.40546
154 2RHW C0E 0.03285 0.40523
155 3ZEI AWH 0.005958 0.40519
156 3PVT 3HC 0.01107 0.40515
157 2GSD NAD 0.007729 0.40514
158 2VLH PM9 0.003531 0.4051
159 4HZX G39 0.01114 0.40504
160 1R6D DAU 0.02206 0.40501
161 1I52 CTP 0.00724 0.40486
162 3ZY6 GFB 0.003593 0.40482
163 3PJU C2E 0.004044 0.40481
164 4C1K PEP 0.0003253 0.40475
165 4PLG NAI 0.0114 0.40464
166 3U4C NDP 0.00743 0.40442
167 2NLI LAC 0.02581 0.40438
168 1OYB HBA 0.005158 0.40436
169 2ET1 GLV 0.008751 0.40435
170 1HKU NAD 0.01161 0.40431
171 1YOE RIB 0.008969 0.40392
172 1RM4 NDP 0.02449 0.40385
173 2F2U M77 0.001062 0.40381
174 1EB9 HBA 0.002592 0.40359
175 4MWV BCZ 0.02488 0.40356
176 2RL1 UD1 0.00489 0.4035
177 2V6O FAD 0.04574 0.40343
178 1VKO NAD 0.03168 0.40333
179 1RYD NDP 0.01332 0.40301
180 4Q3R XA2 0.004775 0.403
181 3SJ7 NDP 0.008109 0.40292
182 3VPD ANP 0.004059 0.40282
183 2HGS ADP 0.004063 0.40281
184 1AUX AGS 0.002335 0.40281
185 2B82 ADN 0.004075 0.40276
186 3O2K QRP 0.0002272 0.40252
187 2GSQ GBI 0.006405 0.40239
188 2BNF UTP 0.008854 0.40212
189 3ZZL TRP 0.02071 0.40198
190 2YNM ADP 0.003806 0.40185
191 4M37 SAH 0.003956 0.40122
192 1GS5 ANP 0.01212 0.40121
193 2B5W NAP 0.013 0.40117
194 4QN6 LNV 0.01227 0.40099
195 3P0K FAD 0.005124 0.40091
196 4CMF PXG 0.02414 0.40091
197 2YNM PMR 0.007006 0.40088
198 3D3W NAP 0.01242 0.40078
199 3O55 FAD 0.005168 0.40077
200 3QUR ADP 0.009241 0.40068
201 4K5S FAD 0.02038 0.40045
202 2GYI HYA 0.009451 0.4003
203 2YC5 6BC 0.01288 0.40015
204 3K3G MMU 0.004038 0.39983
205 1TOI HCI 0.007471 0.3998
206 4HR0 PLM 0.004895 0.39976
207 1C0I BE2 0.02341 0.39975
208 1WVG APR 0.007491 0.39975
209 4R33 SAH 0.01063 0.39966
210 3ZS7 ATP 0.004933 0.39963
211 2VJJ RAM 0.02712 0.39959
212 3ZHO FMN 0.02846 0.3995
213 1B7Y FYA 0.006918 0.39945
214 1CSI CMX 0.01434 0.39945
215 2QF7 AGS 0.002905 0.39935
216 2DWO ADP 0.01185 0.39909
217 1LL2 UPG 0.004509 0.39909
218 3IL6 B83 0.002091 0.39899
219 3T31 DCQ 0.02933 0.39894
220 2VMQ PLP 0.006494 0.3988
221 1G0N NDP 0.01797 0.39876
222 2BJK NAD 0.03054 0.39858
223 3OYZ ACO 0.01515 0.39848
224 2BJF DXC 0.01238 0.39834
225 2RGH FAD 0.01736 0.39831
226 4D7M TDC 0.008172 0.39829
227 1FIQ FAD 0.01452 0.39805
228 1OLS TDP 0.009096 0.39803
229 3BK2 U5P 0.01084 0.39796
230 4BKU 1S5 0.009182 0.39787
231 2CFU 1DB 0.001716 0.39779
232 1SJD NPG 0.006237 0.39767
233 4CG8 G8S 0.0234 0.39701
234 2PTR 2SA 0.03274 0.3969
235 2IUW AKG 0.0002643 0.39673
236 2BII MTV 0.007372 0.39669
237 1NN5 ANP 0.01269 0.3966
238 4L1F FAD 0.01173 0.39659
239 4C12 ADP 0.0316 0.39594
240 3WE0 FAD 0.02356 0.39592
241 2HMT NAI 0.02899 0.39583
242 2YB9 HA0 0.01132 0.39579
243 2H8Z 8CM 0.02123 0.39578
244 1YFX 4AA 0.0007514 0.39576
245 1Z44 FMN 0.00113 0.3957
246 1TFZ 869 0.004905 0.39562
247 2I7C AAT 0.01679 0.3955
248 1OAA OAA 0.01928 0.39536
249 4AF0 IMP 0.03291 0.3952
250 1M7Y PPG 0.008068 0.39519
251 1RKD ADP 0.01827 0.39518
252 1ECC PCP 0.008121 0.39508
253 1VF1 GSH 0.004423 0.39506
254 1WVC CTP 0.04425 0.39494
255 4QDC ASD 0.006706 0.3946
256 1Q7E MET 0.01895 0.39454
257 1L1Q 9DA 0.005278 0.39444
258 4USQ FAD 0.01551 0.39443
259 1CX9 NHP 0.009339 0.39443
260 1QJC PNS 0.04803 0.3944
261 2NP9 YE1 0.01338 0.39435
262 3IAE D7K 0.01689 0.39419
263 1PGP 6PG 0.0219 0.39418
264 4L6C 0BT 0.008625 0.39408
265 3MB5 SAM 0.03578 0.39365
266 4IZC 1GZ 0.02608 0.3936
267 3TCT 3MI 0.02539 0.39359
268 3MBG FAD 0.008146 0.39327
269 4B4D FAD 0.007318 0.39317
270 1N1G BCP 0.04709 0.39306
271 1HEX NAD 0.01229 0.39293
272 2XD9 XD9 0.02218 0.39287
273 1EJE FMN 0.007551 0.39266
274 1FP1 SAH 0.01976 0.39264
275 4J7H TRH 0.00444 0.39264
276 1A27 NAP 0.01479 0.39262
277 1OWB NAD 0.01725 0.39258
278 2H6B 3C4 0.01495 0.39244
279 4IOK ADP 0.00955 0.39239
280 3LPF Z77 0.008637 0.3923
281 1UJ2 C5P 0.01277 0.39229
282 4L1F COS 0.005272 0.39225
283 2QQ0 TMP 0.01532 0.39202
284 2C1Q BTN 0.03242 0.39201
285 1Z41 FMN 0.001572 0.39189
286 1JUV NDP 0.01326 0.39164
287 2PT9 2MH 0.02116 0.39145
288 1H2B NAJ 0.01854 0.39134
289 4AT0 FAD 0.04078 0.39122
290 3QQA TCH 0.005699 0.39101
291 2Z9V PXM 0.0003635 0.39094
292 2YPO PHE 0.009385 0.39093
293 3I51 45C 0.01044 0.39091
294 3UER BTU 0.003681 0.3908
295 1G41 ADP 0.04929 0.39076
296 1GEE NAD 0.01649 0.39075
297 1KBJ FMN 0.01078 0.39037
298 3B20 NAD 0.007729 0.39034
299 4KWI 1TJ 0.03737 0.39031
300 4RJK PYR 0.02897 0.39022
301 1GRO ICT 0.04311 0.39019
302 8CAT NDP 0.007846 0.39009
303 2YHW BM3 0.01599 0.3899
304 1LVL FAD 0.03118 0.38989
305 1KTC NGA 0.0009853 0.38988
306 1GSA GSH 0.02632 0.38984
307 4HZD COA 0.01823 0.3897
308 2HV8 GTP 0.01126 0.38965
309 3SFI 3SF 0.01772 0.38951
310 4B7J G39 0.01779 0.38945
311 3EM1 TYD 0.01086 0.38939
312 1Z48 FMN 0.001904 0.38938
313 2RH4 EMO 0.03746 0.38938
314 1B63 ANP 0.01145 0.38937
315 3V91 UPG 0.008208 0.38936
316 3FC2 IBI 0.001813 0.38925
317 1L8N GCW 0.00933 0.38919
318 3ZLM ANP 0.005598 0.38897
319 2ORV 4TA 0.01179 0.38889
320 2BKA NDP 0.01716 0.38869
321 1TOX NAD 0.009639 0.38866
322 1XVA SAM 0.006626 0.3886
323 1QPB TPP 0.01202 0.38856
324 4EKV BTN 0.02835 0.38852
325 2FWP ICR 0.02501 0.38851
326 4INB 1F6 0.02525 0.38834
327 3RFV NAI 0.02088 0.38801
328 2FFC U5P 0.006889 0.38798
329 4W6Z 8ID 0.02583 0.38794
330 3HAZ FAD 0.02107 0.38784
331 3WQM B29 0.01014 0.38782
332 1JQI CAA 0.01141 0.3877
333 4OE4 NAD 0.02295 0.38762
334 2GIU FBR 0.01273 0.3876
335 1RBO CAP 0.01276 0.38756
336 2PVQ GSH 0.006131 0.38753
337 4A3R CIT 0.01412 0.38751
338 1TYU GLA 0.02827 0.38748
339 1F1V DHY 0.001772 0.38742
340 2XEG CI9 0.01713 0.3873
341 4A8H PUW 0.01865 0.38727
342 1C7S CBS 0.004736 0.38723
343 1HQL GLA 0.0002934 0.38711
344 3KO8 NAD 0.02554 0.38697
345 3CKZ ZMR 0.03482 0.38692
346 2ZYF AKG 0.001515 0.38681
347 3DDC GNP 0.01337 0.38679
348 4B8V NDG 0.01765 0.38679
349 1RZY 5AS 0.007437 0.38675
350 4IXW IXW 0.003143 0.3867
351 2NVK FAD 0.04134 0.38667
352 3WO0 ADP 0.0261 0.38659
353 1FX8 BOG 0.02823 0.38637
354 1FW1 GSH 0.006597 0.38637
355 2VEZ ACO 0.02327 0.38613
356 2Y7G AAE 0.00671 0.3861
357 4MOB COA 0.03345 0.3861
358 2NU8 COA 0.01399 0.38603
359 1KBI FMN 0.01559 0.38585
360 1OD6 PNS 0.03705 0.3858
361 3HAZ NAD 0.02201 0.38578
362 2HGS GSH 0.007921 0.38574
363 1LC8 33P 0.01883 0.38568
364 3ICC NAP 0.02388 0.38568
365 2YGN PCF 0.006893 0.38567
366 4FUA PGH 0.01893 0.3856
367 4ARF IP8 0.004064 0.38515
368 3PNL ADP 0.01199 0.38508
369 1JIL 485 0.009533 0.38491
370 1QCA FUA 0.019 0.3848
371 4BX7 B4F 0.01665 0.38474
372 3B1F NAD 0.01092 0.38471
373 1WXI AMP 0.03117 0.38463
374 3P9C SAH 0.02188 0.38453
375 4DQ2 BTX 0.01851 0.3845
376 1RY2 AMP 0.01475 0.38432
377 1NHK CMP 0.004473 0.38419
378 1D3V ABH 0.01726 0.38414
379 3MTW M3R 0.007601 0.38412
380 4IMG NGF 0.008849 0.38397
381 1ZK7 FAD 0.04336 0.38393
382 1EP2 FAD 0.01149 0.38388
383 1H9G COA 0.01926 0.38383
384 4PVV HO4 0.04156 0.38373
385 3W54 RNB 0.002773 0.38354
386 1A8R GTP 0.01179 0.38347
387 3LST SAH 0.006046 0.38337
388 1YBQ BDH 0.03801 0.38329
389 2BNE U5P 0.0266 0.38317
390 2DDH FAD 0.03172 0.38317
391 2G86 UMP 0.04311 0.38307
392 1T0S BML 0.02025 0.38298
393 4BMO FMN 0.01856 0.38292
394 3QO8 SSA 0.03694 0.38273
395 3M0J OAF 0.03473 0.38272
396 1E4E PHY 0.002579 0.38242
397 3WKX FUB 0.001235 0.38237
398 3DG6 MUC 0.004615 0.38231
399 3GEG NAD 0.025 0.38224
400 3H9E NAD 0.02157 0.38191
401 2XBN PMP 0.01974 0.38188
402 3DLA NXX 0.01976 0.38186
403 4NES UDP 0.006925 0.38184
404 4M3B 2B2 0.0163 0.3818
405 3MCT SAH 0.01633 0.38177
406 2FYU FDN 0.00885 0.38171
407 2VBQ BSJ 0.0302 0.3816
408 1Z42 FMN 0.01033 0.3815
409 1MG1 MAL 0.01253 0.38149
410 1NJR XYL 0.02423 0.38139
411 3TKA SAM 0.01502 0.38138
412 1F7L COA 0.03629 0.38137
413 1Z45 UPG 0.01044 0.38133
414 1T57 FMN 0.0151 0.38128
415 1NZY BCA 0.01516 0.38122
416 1PL6 572 0.03131 0.38097
417 4C6F NCD 0.006727 0.38087
418 1E4E ADP 0.0123 0.38079
419 3B1J NAD 0.02513 0.38076
420 1VJT NAD 0.01083 0.38073
421 2HW1 ANP 0.01086 0.38069
422 3QXC ATP 0.01582 0.38052
423 1MK1 APR 0.01589 0.38045
424 3SVL FMN 0.006999 0.38044
425 1B4P GPS 0.03018 0.38033
426 1WKL ATP 0.01349 0.38029
427 1GAD NAD 0.01976 0.38027
428 2GDZ NAD 0.03274 0.3802
429 3BAZ NAP 0.01985 0.38019
430 3DAG FEG 0.02397 0.38012
431 2HVW DDN 0.007422 0.38001
432 2J7T 274 0.01834 0.37984
433 1F74 NAY 0.007368 0.37973
434 3CQD ATP 0.0386 0.37971
435 3I8P 840 0.01319 0.37965
436 4I71 AGV 0.01495 0.37959
437 2YCD GTB 0.005844 0.37949
438 3JQ3 ADP 0.006676 0.37943
439 2J51 DKI 0.00513 0.3794
440 4MPN PV0 0.02099 0.37926
441 1HDG NAD 0.01905 0.37921
442 1KBI PYR 0.02318 0.37917
443 2C7G FAD 0.04249 0.37914
444 1V1A KDG 0.01722 0.37912
445 1QDS PGA 0.003751 0.37885
446 4NPT 017 0.002229 0.37883
447 1X8X TYR 0.003234 0.37883
448 1JA9 PYQ 0.01954 0.37879
449 2JBH 5GP 0.006139 0.37864
450 1GSL FUC 0.007858 0.37839
451 1DSS NAD 0.02214 0.37836
452 1KWK GAL 0.01269 0.37819
453 4LXH C1E 0.01452 0.3781
454 4OJ8 AKG 0.01458 0.37803
455 1Z4V DAN 0.03456 0.37798
456 1I0Z NAI 0.02283 0.37785
457 1R6W 164 0.001487 0.37771
458 4ME6 ADP 0.002477 0.37753
459 4KXV TDP 0.04672 0.37745
460 2BTO GTP 0.04536 0.37742
461 3WAS BGC 0.02938 0.37739
462 1F3F D4D 0.03596 0.3773
463 3MMR ABH 0.02263 0.37719
464 3ZRR PXG 0.01541 0.37714
465 4COQ SAN 0.001047 0.37711
466 4LKK SIA 0.0301 0.37697
467 1Y13 BIO 0.002578 0.37693
468 3U5S FAD 0.01765 0.37688
469 1V1A ADP 0.02329 0.3767
470 1XIU REA 0.004517 0.37667
471 2WL9 MBD 0.01396 0.37667
472 3H22 B53 0.008426 0.37665
473 1XVV CCQ 0.04625 0.37651
474 1ZGA HMK 0.006355 0.37647
475 2VAR KDF 0.008067 0.37646
476 2VAR KDG 0.008067 0.37646
477 4P87 4NP 0.02251 0.37643
478 2VQ5 HBA 0.006323 0.37639
479 4E13 NAD 0.02087 0.37596
480 5FIT AP2 0.01272 0.37595
481 3IB8 AMP 0.002685 0.37574
482 3RHZ UDP 0.0099 0.37567
483 2EFJ 37T 0.002656 0.37556
484 1CTU ZEB 0.01923 0.37548
485 3NFZ 3NF 0.003056 0.37548
486 2R14 FMN 0.04295 0.37546
487 3OZG SSI 0.009295 0.37536
488 2TPL HPP 0.01521 0.37529
489 3CKJ CIT 0.02671 0.37522
490 1B55 4IP 0.007402 0.37521
491 1B9I PXG 0.02444 0.37507
492 3B96 FAD 0.0473 0.37496
493 1O0S NAI 0.02461 0.37495
494 1H65 GDP 0.01989 0.37492
495 3EE4 MYR 0.006449 0.37491
496 1EZV SMA 0.02755 0.3747
497 2E1Z B4P 0.02764 0.37465
498 1RQH PYR 0.001085 0.37464
499 4IEN GDP 0.03906 0.37456
500 1UCN ADP 0.01063 0.37452
501 4F4S EFO 0.02094 0.37408
502 4C25 13P 0.0435 0.37399
503 4J7H TLO 0.02124 0.37385
504 3NGU ADP 0.01259 0.37377
505 2RHQ GAX 0.01682 0.37367
506 3FED BIX 0.01682 0.37367
507 2Q9U FMN 0.02157 0.37359
508 2J5S KTA 0.004829 0.37356
509 3OIG IMJ 0.03241 0.37352
510 1MZV AMP 0.003469 0.37341
511 4PRX ADP 0.0363 0.37306
512 1K27 MTM 0.04771 0.373
513 1A27 EST 0.006937 0.37296
514 1WHT BZS 0.001682 0.37288
515 1VQ2 DDN 0.01767 0.37287
516 2HVW DCP 0.008072 0.37285
517 9LDT NAD 0.03713 0.37268
518 4M2K PLP 0.008275 0.37263
519 3S6T OAN 0.01235 0.37237
520 1EYE PMM 0.01203 0.37217
521 3CF6 SP1 0.0415 0.37217
522 4F2O QUS 0.008095 0.37213
523 2AG8 NAP 0.02666 0.37191
524 2C81 PMP 0.01647 0.37184
525 4JP3 CIT 0.003414 0.37183
526 3E4O SIN 0.002139 0.37181
527 1SOW NAD 0.0497 0.37166
528 4DEC UDP 0.005279 0.37154
529 1ZS6 ADP 0.0006276 0.37149
530 3ZOD FMN 0.04708 0.37132
531 2AQJ TRP 0.009269 0.37127
532 1K6M AGS 0.0196 0.37121
533 4DL8 UMP 0.02502 0.37116
534 1Q11 TYE 0.002486 0.37097
535 3UH0 TSB 0.02542 0.37091
536 2AMV BIN 0.003076 0.37078
537 3QP4 HL0 0.008422 0.37073
538 3BL6 FMC 0.02293 0.37069
539 3VTF UPG 0.02911 0.37046
540 3PL8 G3F 0.03236 0.37039
541 1SNY NAP 0.04405 0.36975
542 4M5P FMN 0.02445 0.36964
543 4NAO AKG 7.862e-05 0.36955
544 4LHM AZZ 0.002638 0.36949
545 2J0W ADP 0.02199 0.36936
546 1P9B IMO 0.02798 0.36933
547 3V1V GST 0.01951 0.36914
548 2WM1 13P 0.007193 0.36912
549 1I2L DCS 0.02243 0.36904
550 2Q37 3AL 0.003288 0.36883
551 2Z1U ATP 0.02577 0.36879
552 4L7I SAM 0.01998 0.36876
553 3P7I P7I 0.001909 0.36854
554 4Q3S X7A 0.04368 0.36844
555 3BW2 FMN 0.04772 0.36838
556 4AIG FLX 0.01597 0.36837
557 4KCT PYR 0.002175 0.36829
558 3KJI ADP 0.02061 0.36827
559 1GV0 NAD 0.04832 0.36816
560 1POC GEL 0.02706 0.36799
561 1V2X SAM 0.02105 0.36793
562 1AUA BOG 0.008138 0.36776
563 2D2I NAP 0.0456 0.36771
564 3T2W BTN 0.007423 0.36767
565 1E5F PLP 0.01596 0.36764
566 2BMR 3NT 0.02483 0.3674
567 1BWV CAP 0.03159 0.36733
568 4WBD ADP 0.002461 0.36724
569 1W7J ADP 0.02535 0.36706
570 1HYE NAP 0.04767 0.36696
571 2ZO9 MLI 0.002577 0.36695
572 3O03 GCO 0.007856 0.36689
573 4BCS BTN 0.0226 0.3668
574 4I9A NCN 0.04257 0.36659
575 4HZO COA 0.009698 0.36647
576 1GVF PGH 0.009577 0.36646
577 4CKL SM8 0.04132 0.36629
578 4LMB CYS 0.02353 0.36615
579 3O7B SAH 0.02752 0.36574
580 3DX5 DHB 0.005793 0.36571
581 1Z45 GAL 0.005718 0.36569
582 4BT5 23B 0.00495 0.36556
583 4B9E FAH 0.02804 0.36543
584 1V03 BGC 0.006224 0.36542
585 2OI2 DP6 0.01462 0.36532
586 2WCV FUC 0.004272 0.36495
587 1YOA FAD 0.04075 0.36487
588 4AQL TXC 0.02564 0.36478
589 3CL7 HYN 0.04536 0.36473
590 3UIE ADX 0.0207 0.36466
591 2ZJ3 G6P 0.01358 0.36465
592 2VAR AMP 0.01069 0.36461
593 2CJH AKG 0.01282 0.36461
594 1QW9 KHP 0.03535 0.36457
595 1VPT SAM 0.03792 0.36432
596 1A59 COA 0.02642 0.36429
597 3BLI ACO 0.02648 0.36426
598 1MXI SAH 0.03404 0.36425
599 2IYG FMN 0.02111 0.36422
600 2QQF A1R 0.0426 0.36413
601 1ECM TSA 0.007623 0.36412
602 2P69 PLP 0.002927 0.3641
603 1VE3 SAM 0.04291 0.36401
604 2TOH HBI 0.03084 0.3639
605 4WX0 HXD 0.01604 0.36375
606 1TH8 ADP 0.01523 0.36357
607 4WNB 4BN 0.03563 0.3635
608 1D2S DHT 0.007164 0.36343
609 4UOH ADP 0.003707 0.36324
610 4G28 0W8 0.01154 0.36322
611 1GJW MAL 0.006715 0.36307
612 2BR9 ARG 0.02083 0.36279
613 1FDJ 2FP 0.0291 0.36275
614 4W97 UCA 0.04639 0.3627
615 4IS0 GDS 0.007132 0.36266
616 1Y42 TYR 0.004273 0.36266
617 1UOU CMU 0.01625 0.3625
618 1MOQ GLP 0.02187 0.36248
619 3A2B PLP 0.04264 0.36238
620 4LFL TG6 0.01628 0.36232
621 2YCJ C2F 0.01489 0.36231
622 1NF8 ISC 0.01047 0.36229
623 1VR0 3SL 0.009407 0.36226
624 1XX4 BAM 0.004837 0.36213
625 1UBY DMA 0.03462 0.36202
626 3SUC ATP 0.03557 0.36158
627 6FIV 3TL 0.03141 0.36152
628 3QP6 HL6 0.01689 0.36113
629 1E2S CSN 0.02011 0.36109
630 4KOA NDP 0.0323 0.36107
631 2EFJ SAH 0.04199 0.36081
632 1P9B GDP 0.04275 0.36051
633 2ZSC BTN 0.02457 0.36049
634 1FDJ 13P 0.03356 0.36046
635 1R5A GTS 0.007544 0.36044
636 3HT5 PMP 0.02637 0.36011
637 1JK4 CYS 0.01338 0.36007
638 4E28 0MZ 0.01091 0.35974
639 4BI7 PGA 0.01087 0.35944
640 2OZE AGS 0.03665 0.35904
641 2YDW WSH 0.0208 0.35891
642 2QCX PF1 0.002699 0.35888
643 4G10 GSH 0.005871 0.35878
644 3ACC 5GP 0.02446 0.3582
645 4P4T GDP 0.04999 0.35794
646 2CE7 ADP 0.03172 0.35741
647 4KCT FDP 0.0229 0.35737
648 2PJL 047 0.04944 0.35622
649 2C5S AMP 0.00919 0.35614
650 2IMP LAC 0.03489 0.3561
651 3ZF8 GDP 0.02403 0.356
652 4M5P 23W 0.003722 0.35593
653 3F3E LEU 0.01899 0.35587
654 2JFV FLC 0.002296 0.3558
655 2NZU BG6 0.01096 0.35564
656 2E1A MSE 0.01257 0.35561
657 2YIV NBN 0.000605 0.35557
658 3SCH TB6 0.001818 0.35547
659 1UAY ADN 0.01963 0.35479
660 1UZN NAP 0.02725 0.3546
661 4G8N G8M 0.02075 0.35425
662 3UST FAD 0.04972 0.35412
663 1H16 PYR 0.00368 0.35386
664 3UEC ALA 0.01088 0.35374
665 2V5K OXM 0.01748 0.35343
666 3DDN HPV 0.008138 0.35337
667 1WDA BAG 0.01738 0.35329
668 3O2K DST 0.002171 0.35294
669 2VPR TDC 0.04169 0.35292
670 1OGD RIP 0.005046 0.35287
671 4AMV F6R 0.02536 0.35271
672 3CBG FER 0.0003796 0.35264
673 4M5S GLY 0.04283 0.35253
674 2VWT PYR 0.00102 0.35249
675 4LNL PLG 0.03321 0.35241
676 1C7R PA5 0.009374 0.3522
677 4CIB 7UZ 0.002554 0.35195
678 2UX9 FMN 0.003059 0.35177
679 1A5V Y3 0.01667 0.35153
680 1ZGA SAH 0.01503 0.35125
681 2WQ5 MIY 0.00954 0.35107
682 3UIE ANP 0.03319 0.35106
683 4FGC PQ0 0.005933 0.35106
684 2F7C CCU 0.003798 0.35089
685 4JEJ 1GP 0.02449 0.35084
686 1GU3 BGC 0.02578 0.35067
687 1QB7 ADE 0.03376 0.35065
688 4C2G ALA 0.006469 0.35063
689 1PX8 XYP 0.009413 0.35008
690 3IHB GLU 0.006721 0.34993
691 1QPB PYM 0.009412 0.34966
692 4KGM ATP 0.01536 0.34912
693 3V1U HXC 0.0193 0.34905
694 2FUE M1P 0.007821 0.349
695 2W1A TSA 0.01848 0.34868
696 1ULE GLA 0.009577 0.3485
697 2PYU IMP 0.0119 0.3478
698 1II5 GLU 0.01489 0.34744
699 2WCI GSH 0.008353 0.34718
700 3QDV NDG 0.003521 0.34703
701 1ZZ7 S0H 0.0165 0.34667
702 3QDX CBS 0.003835 0.34648
703 4E28 9MZ 0.01131 0.34646
704 1O9U ADZ 5.639e-05 0.34623
705 4G4S LDZ 0.02778 0.34604
706 2WOR 2AN 0.004131 0.34603
707 2G36 TRP 0.02799 0.34567
708 2AZ3 CDP 0.008865 0.34556
709 2Q8M AMP 0.04392 0.34499
710 4HON AKG 0.03369 0.34481
711 1FMB HYB 0.04894 0.34461
712 1Y2W NAG 0.01646 0.34442
713 2ZJF BSU 0.04091 0.34437
714 3PLN U5P 0.02387 0.34429
715 1B5E DCM 0.03554 0.34408
716 2QF7 COA 0.02201 0.34373
717 3BHO B4P 5.598e-05 0.34347
718 1H8P PC 0.006917 0.34346
719 1U3I GSH 0.0181 0.34297
720 3QV9 QV7 0.0163 0.3427
721 1C1L GAL 0.002811 0.34246
722 4HON ALA 0.03975 0.34233
723 1I0Z OXM 0.003038 0.34225
724 1RZM E4P 0.002167 0.34197
725 1KC7 PPR 0.02278 0.34176
726 3LM9 ADP 0.02288 0.341
727 3UCJ AZM 0.04966 0.34083
728 1UW1 ADP 0.04332 0.34005
729 4ASL GAL 0.01913 0.33993
730 4USS GSH 0.02016 0.33949
731 1GJW GLC 0.004039 0.3393
732 4EXO PYR 0.003248 0.33927
733 4DEW LU2 0.04691 0.33909
734 2HW1 FRU 0.01576 0.33854
735 2DWO F6P 0.03025 0.33836
736 1VBH PEP 0.02903 0.33831
737 2VDJ HSE 0.001448 0.33789
738 1IS3 LAT 0.008829 0.33786
739 1M1B SPV 0.02738 0.33773
740 3ZTV ADN 0.01979 0.33767
741 1HK8 DGT 0.003749 0.33758
742 1RZM PEP 0.01197 0.33729
743 4KSY 1SY 0.03187 0.33703
744 2ZE3 AKG 0.03545 0.33695
745 1GPJ GMC 0.01504 0.33689
746 1T10 F6P 0.003874 0.33664
747 3W8S GSH 0.02914 0.33622
748 4IS0 1R4 0.01315 0.33612
749 3OCZ SRA 0.03782 0.33548
750 2QLX RM4 0.003566 0.33534
751 2PFC PLM 0.01672 0.33473
752 1YFZ IMP 0.01003 0.33464
753 1H16 COA 0.04546 0.33427
754 3RK0 AMP 0.04555 0.33424
755 2Q8H TF4 0.0001729 0.33405
756 2PNZ 5GP 0.01409 0.33395
757 2BOI MFU 0.02422 0.33361
758 4GJY OGA 0.0001695 0.33258
759 2YLD CMO 0.01409 0.33241
760 4IHQ ADP 0.02412 0.33097
761 1PEA ACM 0.02431 0.33028
762 1P9B HDA 0.03362 0.33026
763 2Q3M MLA 0.001445 0.3302
764 4AF5 CIT 0.01503 0.32981
765 2R00 OEG 0.006036 0.32972
766 1H2B OCA 0.03375 0.32935
767 1FBL HTA 0.02947 0.32932
768 4M51 BEZ 0.01598 0.32832
769 1NOW IFG 0.02621 0.32822
770 3MCT 3MC 0.02532 0.32756
771 3TFC PEP 0.03232 0.32677
772 3L24 GOA 0.005067 0.32617
773 3QDT A2G 0.03028 0.3261
774 3QDY CBS 0.01527 0.32603
775 3GTD MLI 0.01025 0.32592
776 1DXY COI 0.01089 0.32462
777 4N1T 2GD 0.03328 0.32416
778 2DKH 3HB 0.00408 0.32354
779 3PAK MAN 0.02647 0.3232
780 1R37 ETX 0.04893 0.32224
781 1JZN BGC 0.005488 0.32172
782 1SOW OXL 0.01629 0.32125
783 3S1W FLC 0.01231 0.32091
784 1WTC ACP 0.01499 0.32066
785 3QDX A2G 0.02028 0.32041
786 2WKQ FMN 0.03903 0.32039
787 3QDW NDG 0.03412 0.31982
788 2GC0 PAN 0.01634 0.31962
789 1B4B ARG 0.007377 0.31958
790 1G8S MET 0.03582 0.319
791 3ZGE ASP 0.008246 0.31873
792 1V7R CIT 0.004289 0.31846
793 3PMD 11A 0.04457 0.31824
794 3CL5 SIO 0.01033 0.31794
795 3CBG 4FE 0.006196 0.31772
796 3WCS NAG 0.004897 0.31672
797 9LDT OXM 0.00858 0.31639
798 2PR5 FMN 0.0447 0.31611
799 3QDY A2G 0.02833 0.31533
800 3UDG TMP 0.008584 0.31525
801 1QO0 BMD 0.01726 0.3152
802 2Z6D FMN 0.04832 0.31465
803 3QDV A2G 0.0354 0.31421
804 1B74 DGN 0.01997 0.31415
805 1NF8 BOG 0.04512 0.314
806 1JAC AMG 0.005169 0.31394
807 3QDW A2G 0.01887 0.31379
808 1Z44 NPO 0.007982 0.31373
809 1BTN I3P 0.00557 0.31309
810 4WBD CIT 0.03816 0.313
811 2OHV NHL 0.04831 0.31278
812 3R51 MMA 0.02499 0.31266
813 1NH8 AMP 0.03675 0.31262
814 3P7N FMN 0.04999 0.31209
815 1SC3 MLI 0.0449 0.31198
816 2V5E SCR 0.01579 0.31166
817 1KO0 DLY 0.03381 0.31163
818 1H0C AOA 0.004471 0.31146
819 1GPJ CIT 0.0276 0.30981
820 2ASF CIT 0.004219 0.30976
821 2XI7 XI7 0.0119 0.30949
822 3F81 STT 0.01302 0.30911
823 1N5S ADL 0.04902 0.30808
824 2FGQ MLT 0.04672 0.30787
825 1QH9 LAC 0.03105 0.30704
826 3VPD CIT 0.009389 0.30684
827 4G0A G 0.002091 0.30596
828 3F8C HT1 0.04691 0.30408
829 2YIV YIV 0.04028 0.30406
830 4LO6 SIA 0.04889 0.30368
831 4OCT AKG 0.01419 0.30352
832 4B16 NAG 0.0005019 0.30086
833 2XRH NIO 0.03137 0.29909
834 2YD6 FLC 0.001121 0.29769
835 1J3R 6PG 0.04125 0.29728
836 2YBP 2HG 0.02013 0.29712
837 2X2T GAL 0.02778 0.29706
838 2BZ1 TAU 0.009223 0.29612
839 3VPD BUA 0.04318 0.29479
840 3TKA CTN 0.003721 0.29109
841 3UBW 6SP 0.002093 0.29067
842 1FUR MLT 0.01691 0.29064
843 2PXJ OGA 0.04935 0.28671
844 4BMB LAT 0.03281 0.28569
845 3OPT AKG 0.01516 0.28534
846 2Q8E OGA 0.0435 0.28492
847 4DEC 3PG 0.03277 0.28483
848 2PNC CLU 0.02019 0.27557
849 3QRC SCR 0.01145 0.26785
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