Receptor
PDB id Resolution Class Description Source Keywords
2yc0 2.15 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLU HOMO SAPIENS OXIDOREDUCTASE DIOXYGENASE METAL-BINDING TRANSCRIPTION HLOOP-HELIX-BETA DSBH FACIAL TRIAD ASPARAGINYL/ASPARTYL HYDROXYLASE TRANSCRIPTION AND EPIGENETIC REGULATION SIGNADEVELOPMENT CELL STRUCTURE ANKYRIN REPEAT DOMAIN ARD BEHYDROXYLATION TRANSCRIPTION ACTIVATOR/INHIBITOR PHOSPHORYS-NITROSYLATION
Ref.: THE ONCOMETABOLITE 2-HYDROXYGLUTARATE INHIBITS HISTONE LYSINE DEMETHYLASES. EMBO REP. V. 12 463 2011
Ligand Information
Ligand Validity Binding Data Ligand Warnings Chemaxon Viewer Molecular Weight (Da) Formula SMILES
2HG Valid ic50 = 1500 uM none 148.114
C5 H8 O5
C(CC(=O)O)[C@H](C(=O)O)O
GOL Invalid - none 92.094
C3 H8 O3
C(C(CO)O)O
SO4 Invalid - none 96.063
O4 S
[O-]S(=O)(=O)[O-]
FE2 Part of Protein - none 55.845
Fe
[Fe+2]
90% Homology Family

The Class containing this family consists of a total of 7 families.

Leader:    2WA4     FACTOR INHIBITING HIF-1 ALPHA WITH N,3-DIHYDROXYBENZAMIDE
No: PDB id Binding Data Representative ligand
1 2W0X ic50 = 625 uM PD2
2 1MZF - AKG
3 2WA3 ic50 = 1 mM A29
4 2CGN - SIN
5 2WA4 ic50 = 18 uM 069
6 4AI8 ic50 > 100 uM DZA
7 1MZE - TAR
8 2YDE ic50 = 189 uM S2G
9 2YC0 ic50 = 1500 uM 2HG
More Information
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