Receptor
PDB id Resolution Class Description Source Keywords
2xm9 2.5 Å EC: 2.7.11.1 STRUCTURE OF A SMALL MOLECULE INHIBITOR WITH THE KINASE DOMA CHK2 HOMO SAPIENS TRANSFERASE CANCER
Ref.: STRUCTURE-BASED DESIGN OF POTENT AND SELECTIVE 2-(QUINAZOLIN-2-YL)PHENOL INHIBITORS OF CHECKPOINT KI J.MED.CHEM. V. 54 580 2011
Ligand Information
Ligand Validity Binding Data Ligand Warnings Chemaxon Viewer Molecular Weight (Da) Formula SMILES
NO3 Invalid - none 62.005
N O3
[N+](=O)([O-])[O-]
LWH Valid ic50 = 0.009 uM none 372.423
C21 H20 N6 O
c1ccc2c(c1)c(nc(n2)c3cc(ccc3O)c4ccn[nH]4)N[C@H]5CCNC5
90% Homology Family

The Class containing this family consists of a total of 69 families.

Leader:    2XK9     STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 (CHK2) IN COMPLEX INHIBITOR PV1533
No: PDB id Binding Data Representative ligand
1 2YCQ ic50 = 0.14 nM UPX
2 2YIT ic50 = 0.29 nM YIT
3 2W0J ic50 = 240 nM ZAT
4 2W7X ic50 = 138 nM D1A
5 4A9U - A9U
6 2XK9 ic50 = 0.03 nM XK9
7 2YCS ic50 = 1.36 nM NXP
8 2YCF ic50 = 0.7 nM YCF
9 2WTI ic50 = 0.092 uM WTI
10 2YIR ic50 = 0.17 nM YIR
11 2XBJ ic50 = 0.86 uM XBJ
12 2XM9 ic50 = 0.009 uM LWH
13 2YCR ic50 = 69.6 nM HCW
14 2YIQ ic50 = 12.67 nM YIQ
15 2WTJ ic50 = 0.7 uM WTJ
16 2CN5 - ADP
More Information
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