Receptor
PDB id Resolution Class Description Source Keywords
2xj2 2.2 Å EC: 2.7.11.1 PROTEIN KINASE PIM-1 IN COMPLEX WITH SMALL MOLECULE INHIBITOR HOMO SAPIENS TRANSFERASE PHOSPHORYLATION PROTEIN KINASE FOLD
Ref.: CRYSTALLOGRAPHIC FRAGMENT SCREEN IDENTIFIES CINNAMI DERIVATIVES AS STARTING POINTS FOR POTENT PIM-1 INH ACTA CRYSTALLOGR.,SECT.D V. 67 156 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
985 A:1001;
Valid;
none;
Kd = 66 nM
338.404 C19 H22 N4 O2 C[N@]...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3VBQ 1.85 Å EC: 2.7.11.1 EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROP ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHID ESIGN HOMO SAPIENS PIM1 ROSSMANN FOLD TRANSFERASE-TRANSFERASE INHIBITOR COMPL
Ref.: IMPLICATIONS OF PROMISCUOUS PIM-1 KINASE FRAGMENT I HYDROPHOBIC INTERACTIONS FOR FRAGMENT-BASED DRUG DE J.MED.CHEM. V. 55 2641 2012
Members (44)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 129 families.
1 4ALW ic50 = 27 nM HY7 C16 H17 Br N4 O2 CN1CCN(CC1....
2 3BGZ Ki = 0.55 uM VX3 C21 H15 N O2 c1ccc(cc1)....
3 2XIZ - XIZ C8 H7 N O2 c1cnccc1C=....
4 1YXU - AMP C10 H14 N5 O7 P c1nc(c2c(n....
5 1XWS - BI1 C25 H24 N4 O2 CN(C)CCCn1....
6 3R04 ic50 = 0.12 uM UNQ C19 H20 N4 O3 c1cc2c(cc1....
7 1YI3 ic50 = 4 uM LY2 C19 H17 N O3 c1ccc(cc1)....
8 2XJ2 Kd = 66 nM 985 C19 H22 N4 O2 C[N@]1CCCN....
9 2C3I Kd = 25 nM IYZ C18 H18 N4 O CC(=O)c1cc....
10 3VBW ic50 = 6 uM 0FN C10 H5 N O2 c1ccc2c(c1....
11 1YI4 - ADN C10 H13 N5 O4 c1nc(c2c(n....
12 3F2A ic50 = 57 nM 985 C19 H22 N4 O2 C[N@]1CCCN....
13 3R00 ic50 = 8.5 uM UNJ C9 H5 Br O3 c1cc2c(cc1....
14 3A99 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
15 3C4E ic50 ~ 100 uM C4E C13 H11 N3 c1ccc(cc1)....
16 3MA3 ic50 = 60 nM 01I C16 H8 O6 c1cc2c(cc(....
17 2XIX - XIX C2 H5 N5 c1([nH]nc(....
18 2J2I ic50 = 0.2 uM LY4 C28 H28 N4 O3 CN(C)C[C@@....
19 3VBX ic50 = 17 uM 0FO C9 H5 Br O3 c1cc2c(cc1....
20 3VBQ ic50 = 470 pM 0F5 C20 H23 N5 O2 S c1cc(cc(c1....
21 2OI4 ic50 = 2.5 nM JM1 C23 H12 F N3 O3 Ru c1ccc2c(c1....
22 2OBJ ic50 = 0.05 uM VRV C18 H11 Br N2 O2 c1ccc(cc1)....
23 3WE8 - RUI C18 H7 N2 O2 Ru c1cc2c3c4c....
24 2O3P ic50 = 1.1 uM QUE C15 H10 O7 c1cc(c(cc1....
25 3VBY ic50 = 28 uM 0FR C13 H9 N O2 c1ccc2c(c1....
26 3BWF ic50 = 0.6 nM DWC C23 H9 N3 O4 Os c1cc2c3c(c....
27 2XIY - XIY C8 H8 N2 O c1ccc2c(c1....
28 4BZO ic50 = 0.013 uM 676 C22 H22 F N5 O2 c1ccc(cc1)....
29 4A7C ic50 = 0.006 uM E46 C18 H19 F3 N6 O c1cc(cc(c1....
30 3BGQ Ki = 11 nM VX2 C18 H18 F3 N5 c1cc(cc(c1....
31 3R02 ic50 = 0.001 uM UNM C15 H17 Br N2 O3 c1c2cc(oc2....
32 4K18 Ki = 1.1 nM 1OB C21 H14 F N5 O2 c1cc(ccc1C....
33 4K0Y Ki = 15 nM 1OA C18 H18 F N5 O2 c1cc(ccc1N....
34 4DTK ic50 < 0.004 uM 7LI C18 H23 N3 O3 S CC(C)Oc1cc....
35 2BIK - BI1 C25 H24 N4 O2 CN(C)CCCn1....
36 4BZN ic50 = 1.441 uM UGX C18 H23 N3 O2 S CC(C)(C)CN....
37 3VBV ic50 = 10 uM 0FK C10 H8 N2 O2 c1cc2ccc(n....
38 3UIX ic50 = 0.151 uM Q17 C17 H18 N4 O c1ccc2c(c1....
39 1YXV - LI6 C10 H9 N O3 CN1c2ccccc....
40 3UMW ic50 = 3 nM 596 C22 H22 N4 O3 COc1ccc2c(....
41 1YHS ic50 = 0.01 uM STU C28 H26 N4 O3 C[C@@]12[C....
42 2XJ1 Kd = 28 nM XJ1 C19 H22 N4 O2 c1cc(cc(c1....
43 2O64 Kd = 0.34 uM MYU C15 H10 O8 c1cc(c(cc1....
44 4AS0 - RPS C20 H19 N2 O3 Ru S3 c1c2c(cc3c....
70% Homology Family (52)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 94 families.
1 4ALW ic50 = 27 nM HY7 C16 H17 Br N4 O2 CN1CCN(CC1....
2 3BGZ Ki = 0.55 uM VX3 C21 H15 N O2 c1ccc(cc1)....
3 2XIZ - XIZ C8 H7 N O2 c1cnccc1C=....
4 1YXU - AMP C10 H14 N5 O7 P c1nc(c2c(n....
5 1XWS - BI1 C25 H24 N4 O2 CN(C)CCCn1....
6 3R04 ic50 = 0.12 uM UNQ C19 H20 N4 O3 c1cc2c(cc1....
7 1YI3 ic50 = 4 uM LY2 C19 H17 N O3 c1ccc(cc1)....
8 2XJ2 Kd = 66 nM 985 C19 H22 N4 O2 C[N@]1CCCN....
9 2C3I Kd = 25 nM IYZ C18 H18 N4 O CC(=O)c1cc....
10 3VBW ic50 = 6 uM 0FN C10 H5 N O2 c1ccc2c(c1....
11 1YI4 - ADN C10 H13 N5 O4 c1nc(c2c(n....
12 3F2A ic50 = 57 nM 985 C19 H22 N4 O2 C[N@]1CCCN....
13 3R00 ic50 = 8.5 uM UNJ C9 H5 Br O3 c1cc2c(cc1....
14 3A99 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
15 3C4E ic50 ~ 100 uM C4E C13 H11 N3 c1ccc(cc1)....
16 3MA3 ic50 = 60 nM 01I C16 H8 O6 c1cc2c(cc(....
17 2XIX - XIX C2 H5 N5 c1([nH]nc(....
18 2J2I ic50 = 0.2 uM LY4 C28 H28 N4 O3 CN(C)C[C@@....
19 3VBX ic50 = 17 uM 0FO C9 H5 Br O3 c1cc2c(cc1....
20 3VBQ ic50 = 470 pM 0F5 C20 H23 N5 O2 S c1cc(cc(c1....
21 2OI4 ic50 = 2.5 nM JM1 C23 H12 F N3 O3 Ru c1ccc2c(c1....
22 2OBJ ic50 = 0.05 uM VRV C18 H11 Br N2 O2 c1ccc(cc1)....
23 3WE8 - RUI C18 H7 N2 O2 Ru c1cc2c3c4c....
24 2O3P ic50 = 1.1 uM QUE C15 H10 O7 c1cc(c(cc1....
25 3VBY ic50 = 28 uM 0FR C13 H9 N O2 c1ccc2c(c1....
26 3BWF ic50 = 0.6 nM DWC C23 H9 N3 O4 Os c1cc2c3c(c....
27 2XIY - XIY C8 H8 N2 O c1ccc2c(c1....
28 4BZO ic50 = 0.013 uM 676 C22 H22 F N5 O2 c1ccc(cc1)....
29 4A7C ic50 = 0.006 uM E46 C18 H19 F3 N6 O c1cc(cc(c1....
30 3BGQ Ki = 11 nM VX2 C18 H18 F3 N5 c1cc(cc(c1....
31 3R02 ic50 = 0.001 uM UNM C15 H17 Br N2 O3 c1c2cc(oc2....
32 4K18 Ki = 1.1 nM 1OB C21 H14 F N5 O2 c1cc(ccc1C....
33 4K0Y Ki = 15 nM 1OA C18 H18 F N5 O2 c1cc(ccc1N....
34 4DTK ic50 < 0.004 uM 7LI C18 H23 N3 O3 S CC(C)Oc1cc....
35 2BIK - BI1 C25 H24 N4 O2 CN(C)CCCn1....
36 4BZN ic50 = 1.441 uM UGX C18 H23 N3 O2 S CC(C)(C)CN....
37 3VBV ic50 = 10 uM 0FK C10 H8 N2 O2 c1cc2ccc(n....
38 3UIX ic50 = 0.151 uM Q17 C17 H18 N4 O c1ccc2c(c1....
39 1YXV - LI6 C10 H9 N O3 CN1c2ccccc....
40 3UMW ic50 = 3 nM 596 C22 H22 N4 O3 COc1ccc2c(....
41 1YHS ic50 = 0.01 uM STU C28 H26 N4 O3 C[C@@]12[C....
42 2XJ1 Kd = 28 nM XJ1 C19 H22 N4 O2 c1cc(cc(c1....
43 2O64 Kd = 0.34 uM MYU C15 H10 O8 c1cc(c(cc1....
44 4AS0 - RPS C20 H19 N2 O3 Ru S3 c1c2c(cc3c....
45 4MBI - 26K C13 H17 N7 CN(C)CCNc1....
46 3VBT ic50 = 37 uM 0F9 C9 H7 Cl N2 O c1cc(c(cc1....
47 2O63 Kd = 0.78 uM MYC C15 H10 O8 c1c(cc(c(c....
48 1YXX - LI7 C14 H10 N2 O2 c1ccc2c(c1....
49 3VC4 ic50 = 24 nM 0FS C11 H6 F3 N O2 S c1cc(cc(c1....
50 4K1B Ki = 0.003 nM 1OC C26 H24 F2 N8 O c1ccc(c(c1....
51 4N70 Ki = 0.001 nM 2HX C23 H22 F3 N5 O2 C[C@H]1CN(....
52 4N6Z Ki = 16 nM 2HW C15 H19 N7 O c1cncc(c1N....
50% Homology Family (52)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 68 families.
1 4ALW ic50 = 27 nM HY7 C16 H17 Br N4 O2 CN1CCN(CC1....
2 3BGZ Ki = 0.55 uM VX3 C21 H15 N O2 c1ccc(cc1)....
3 2XIZ - XIZ C8 H7 N O2 c1cnccc1C=....
4 1YXU - AMP C10 H14 N5 O7 P c1nc(c2c(n....
5 1XWS - BI1 C25 H24 N4 O2 CN(C)CCCn1....
6 3R04 ic50 = 0.12 uM UNQ C19 H20 N4 O3 c1cc2c(cc1....
7 1YI3 ic50 = 4 uM LY2 C19 H17 N O3 c1ccc(cc1)....
8 2XJ2 Kd = 66 nM 985 C19 H22 N4 O2 C[N@]1CCCN....
9 2C3I Kd = 25 nM IYZ C18 H18 N4 O CC(=O)c1cc....
10 3VBW ic50 = 6 uM 0FN C10 H5 N O2 c1ccc2c(c1....
11 1YI4 - ADN C10 H13 N5 O4 c1nc(c2c(n....
12 3F2A ic50 = 57 nM 985 C19 H22 N4 O2 C[N@]1CCCN....
13 3R00 ic50 = 8.5 uM UNJ C9 H5 Br O3 c1cc2c(cc1....
14 3A99 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
15 3C4E ic50 ~ 100 uM C4E C13 H11 N3 c1ccc(cc1)....
16 3MA3 ic50 = 60 nM 01I C16 H8 O6 c1cc2c(cc(....
17 2XIX - XIX C2 H5 N5 c1([nH]nc(....
18 2J2I ic50 = 0.2 uM LY4 C28 H28 N4 O3 CN(C)C[C@@....
19 3VBX ic50 = 17 uM 0FO C9 H5 Br O3 c1cc2c(cc1....
20 3VBQ ic50 = 470 pM 0F5 C20 H23 N5 O2 S c1cc(cc(c1....
21 2OI4 ic50 = 2.5 nM JM1 C23 H12 F N3 O3 Ru c1ccc2c(c1....
22 2OBJ ic50 = 0.05 uM VRV C18 H11 Br N2 O2 c1ccc(cc1)....
23 3WE8 - RUI C18 H7 N2 O2 Ru c1cc2c3c4c....
24 2O3P ic50 = 1.1 uM QUE C15 H10 O7 c1cc(c(cc1....
25 3VBY ic50 = 28 uM 0FR C13 H9 N O2 c1ccc2c(c1....
26 3BWF ic50 = 0.6 nM DWC C23 H9 N3 O4 Os c1cc2c3c(c....
27 2XIY - XIY C8 H8 N2 O c1ccc2c(c1....
28 4BZO ic50 = 0.013 uM 676 C22 H22 F N5 O2 c1ccc(cc1)....
29 4A7C ic50 = 0.006 uM E46 C18 H19 F3 N6 O c1cc(cc(c1....
30 3BGQ Ki = 11 nM VX2 C18 H18 F3 N5 c1cc(cc(c1....
31 3R02 ic50 = 0.001 uM UNM C15 H17 Br N2 O3 c1c2cc(oc2....
32 4K18 Ki = 1.1 nM 1OB C21 H14 F N5 O2 c1cc(ccc1C....
33 4K0Y Ki = 15 nM 1OA C18 H18 F N5 O2 c1cc(ccc1N....
34 4DTK ic50 < 0.004 uM 7LI C18 H23 N3 O3 S CC(C)Oc1cc....
35 2BIK - BI1 C25 H24 N4 O2 CN(C)CCCn1....
36 4BZN ic50 = 1.441 uM UGX C18 H23 N3 O2 S CC(C)(C)CN....
37 3VBV ic50 = 10 uM 0FK C10 H8 N2 O2 c1cc2ccc(n....
38 3UIX ic50 = 0.151 uM Q17 C17 H18 N4 O c1ccc2c(c1....
39 1YXV - LI6 C10 H9 N O3 CN1c2ccccc....
40 3UMW ic50 = 3 nM 596 C22 H22 N4 O3 COc1ccc2c(....
41 1YHS ic50 = 0.01 uM STU C28 H26 N4 O3 C[C@@]12[C....
42 2XJ1 Kd = 28 nM XJ1 C19 H22 N4 O2 c1cc(cc(c1....
43 2O64 Kd = 0.34 uM MYU C15 H10 O8 c1cc(c(cc1....
44 4AS0 - RPS C20 H19 N2 O3 Ru S3 c1c2c(cc3c....
45 4MBI - 26K C13 H17 N7 CN(C)CCNc1....
46 3VBT ic50 = 37 uM 0F9 C9 H7 Cl N2 O c1cc(c(cc1....
47 2O63 Kd = 0.78 uM MYC C15 H10 O8 c1c(cc(c(c....
48 1YXX - LI7 C14 H10 N2 O2 c1ccc2c(c1....
49 3VC4 ic50 = 24 nM 0FS C11 H6 F3 N O2 S c1cc(cc(c1....
50 4K1B Ki = 0.003 nM 1OC C26 H24 F2 N8 O c1ccc(c(c1....
51 4N70 Ki = 0.001 nM 2HX C23 H22 F3 N5 O2 C[C@H]1CN(....
52 4N6Z Ki = 16 nM 2HW C15 H19 N7 O c1cncc(c1N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 985; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 985 1 1
2 XJ1 0.453608 0.618182
Similar Binding Sites
Pocket no: 1; Query (leader) PDB : 3VBQ; Ligand: 0F5; Similar sites found: 435
This union binding pocket (no: 1) in the query (biounit: 3vbq.bio1) has 37 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 3VBQ 0F5 2.106e-20 1
2 2JDR GLY 1.13e-11 0.71986
3 1RE8 BD2 1.062e-11 0.71329
4 3MVH GLY 7.717e-10 0.6454
5 2BPM 529 7.604e-09 0.60752
6 2GU8 796 8.124e-08 0.58262
7 2JLD AG1 3.212e-09 0.57233
8 3RWP ABQ 3.73e-07 0.55417
9 2PVN P63 7.134e-09 0.54464
10 2XMY CDK 7.523e-07 0.54163
11 4JDI ARG 2.122e-07 0.53793
12 3IOK 1P6 4.561e-07 0.53371
13 3THB 3TA 7.383e-08 0.5334
14 3FHI ANP 2.095e-08 0.52491
15 2YAK OSV 1.834e-08 0.52439
16 3AT4 CCK 2.289e-07 0.5214
17 4N70 2HX 1.937e-12 0.51772
18 3E8N ATP 1.686e-06 0.51659
19 3IDB ANP 4.215e-09 0.5148
20 4NW6 2NS 9.889e-08 0.51438
21 4F4P 0SB 1.392e-06 0.51327
22 4NM5 ADP 1.64e-06 0.51075
23 3TKI S25 3.838e-09 0.50596
24 1XKK FMM 3.383e-07 0.50529
25 2QCS ANP 4.228e-08 0.50362
26 4BKY 82B 4.867e-09 0.50151
27 4GJ3 0XP 1.075e-07 0.50097
28 2XB7 GUI 1.294e-06 0.49916
29 3LXK MI1 3.59e-07 0.49517
30 4GW8 3RA 1.035e-11 0.49103
31 1XJD STU 2.049e-09 0.49074
32 2Z7R STU 9.825e-09 0.49054
33 4MXO DB8 8.999e-06 0.49054
34 4BHN BH9 2.776e-08 0.48738
35 4K1B 1OC 8.223e-11 0.48733
36 3F7Z 34O 2.051e-09 0.48718
37 4OTH DRN 3.746e-09 0.48646
38 4QTC 38Z 1.506e-07 0.48624
39 3BZ3 YAM 1.086e-05 0.48622
40 4WHZ 3NL 3.776e-05 0.48575
41 2WTV ZZL 2.91e-05 0.48508
42 1OUK 084 0.0001505 0.48412
43 2YAB AMP 6.925e-09 0.48305
44 4MQ1 2C3 1.894e-08 0.48165
45 4N6Z 2HW 3.678e-12 0.48058
46 4FL3 ANP 6.282e-08 0.4789
47 4E93 GUI 1.481e-05 0.4771
48 3LXN MI1 3.273e-08 0.4766
49 4JR7 GNP 3.676e-09 0.47631
50 3BQC EMO 3.525e-08 0.47572
51 2J90 IZA 1.39e-08 0.47414
52 1PHK ATP 1.321e-08 0.47359
53 2EVA ADN 1.074e-06 0.47253
54 4FG8 ATP 1.377e-07 0.47102
55 3RI1 3RH 2.493e-07 0.46933
56 4F65 0S9 2.474e-05 0.46925
57 3DLS ADP 2.827e-09 0.46831
58 1PME SB2 3.911e-05 0.46638
59 3V8T 477 2.644e-05 0.46518
60 2WU6 DKI 1.363e-07 0.46231
61 4P5Z Q7M 6.66e-05 0.46188
62 4I5C C5I 1.257e-07 0.46092
63 2B9F ADP 2.203e-07 0.46055
64 3LQ8 88Z 7.348e-05 0.46033
65 1V0O INR 1.099e-07 0.46012
66 3PVW QRX 1.401e-06 0.45978
67 4IWD 1JC 1.343e-05 0.45712
68 3SXF BK5 1.069e-05 0.45658
69 4NWM 2P5 9.431e-05 0.45642
70 4OTI MI1 7.191e-08 0.45604
71 4JX7 1N6 3.281e-10 0.45601
72 4BTK DTQ 1.855e-07 0.45559
73 4E6D 0NU 2.286e-07 0.4555
74 1VJY 460 1.531e-06 0.45365
75 2NRY STU 3.936e-08 0.45354
76 3ORK AGS 4.121e-06 0.45275
77 3EQR T74 1.113e-06 0.45241
78 2B9I ADP 2.442e-07 0.452
79 4EQC XR1 1.531e-05 0.4517
80 3KF4 B90 0.0001012 0.45166
81 3SG8 TOY 2.238e-05 0.45074
82 4LFI GNP 3.153e-07 0.44924
83 3CXW 7CP 3.319e-10 0.4482
84 4QTB 38Z 7.85e-06 0.44753
85 2X4Z X4Z 1.157e-05 0.44744
86 3SLS ANP 7.713e-07 0.44647
87 2VAG V25 7.617e-08 0.44516
88 4OAC ADP 2.096e-07 0.44464
89 4AG8 AXI 3.001e-05 0.44428
90 4MWH ATP 1.992e-07 0.44413
91 2XNM WGZ 6.411e-06 0.4437
92 3EYG MI1 4.513e-07 0.44365
93 2OFV 242 6.982e-05 0.44358
94 4E6Q 0NV 3.778e-07 0.44297
95 4OH4 ANP 1.493e-07 0.44297
96 3BI6 396 9.034e-07 0.44227
97 4IVD 15T 7.836e-07 0.44196
98 2PVF ACP 1.568e-07 0.44104
99 3E5A VX6 1.036e-05 0.44076
100 4F99 ADP 2.25e-07 0.44059
101 3KRL KRL 1.268e-05 0.43822
102 4IX4 ADP 1.154e-06 0.43744
103 1XR1 ANP 5.067e-09 0.43666
104 4IZY 1J2 2.271e-06 0.43663
105 4E4N 0NL 6.219e-07 0.43648
106 1Y57 MPZ 8.385e-07 0.43602
107 4ANW O92 3.748e-05 0.43587
108 2B9H ADP 5.761e-07 0.43414
109 3EKK GS2 2.212e-06 0.43386
110 4H3Q ANP 1.826e-06 0.43248
111 3VHE 42Q 2.358e-05 0.43241
112 2B9J ADP 7.95e-07 0.43185
113 4F9A ADP 2.847e-07 0.4313
114 3PP0 03Q 4.241e-06 0.43115
115 3E7O 35F 1.137e-05 0.43112
116 2RIO ADP 9.223e-07 0.43106
117 3ALN ANP 1.065e-06 0.42991
118 4MKC 4MK 1.342e-06 0.42932
119 3M2W L8I 8.813e-08 0.42924
120 3C0I 3AM 1.812e-07 0.42916
121 4IJP 1EH 1.466e-06 0.42806
122 4QPM ADP 2.819e-06 0.42778
123 4C4F 7CE 4.443e-07 0.42761
124 3PLS ANP 9.184e-07 0.42678
125 4EUU BX7 1.415e-05 0.42645
126 3IGO ANP 5.616e-06 0.42626
127 4M69 ANP 1.026e-05 0.42615
128 1U59 STU 4.114e-08 0.42581
129 4CFU 2WC 1.119e-07 0.42542
130 1U5R ATP 3.249e-07 0.42535
131 4C2V YJA 0.0001106 0.42521
132 3O0G 3O0 9.136e-08 0.42486
133 3CY2 MB9 1.727e-10 0.42448
134 3TZM 085 4.195e-07 0.42421
135 2R5T ANP 6.471e-07 0.42377
136 1Q8Y ADP 5.01e-06 0.4236
137 3R0T FU9 8.351e-08 0.42353
138 2V7O DRN 2.424e-08 0.4233
139 1CM8 ANP 4.257e-07 0.42286
140 3PE1 3NG 1.723e-08 0.42244
141 3SRV S19 2.067e-07 0.42221
142 3W0O ADP 8.636e-05 0.42199
143 1UNH IXM 6.71e-07 0.42149
144 3PE2 E1B 6.013e-08 0.42129
145 4MK0 29X 1.791e-05 0.42049
146 2OIC STU 1.959e-07 0.42015
147 4L3L 5FI 7.047e-06 0.41992
148 4AOI 4K0 3.075e-06 0.41992
149 3EYH IZA 1.879e-06 0.41969
150 4OUC 5ID 2.24e-07 0.41935
151 4CD0 AWJ 4.472e-06 0.4186
152 2XVD AS6 5.013e-05 0.41857
153 2CSN CKI 0.001531 0.41756
154 4MBI 26K 1.135e-09 0.41751
155 3UIM ANP 5.778e-07 0.41704
156 4NST ADP 1.717e-06 0.41696
157 3HMO STU 9.35e-07 0.4166
158 3GQI ACP 9.413e-07 0.41658
159 4H1M 0YJ 0.000171 0.41647
160 3JPV 1DR 5.093e-11 0.41527
161 4Q5H ANP 2.577e-06 0.41523
162 4E5W 0NT 3.343e-06 0.41457
163 4OA2 ADP 1.458e-06 0.41426
164 4U0I 0LI 0.001792 0.41413
165 3GGF GVD 3.721e-08 0.414
166 1TQP ATP 1.549e-05 0.41399
167 4E1Z 0MX 1.394e-05 0.41394
168 4IDT T28 2.32e-06 0.41303
169 4U44 3D9 2.819e-06 0.41298
170 4OCJ NDG 0.0003997 0.41269
171 3V8S 0HD 2.813e-07 0.41228
172 3GNI ATP 5.773e-06 0.41201
173 4BCN T9N 1.619e-07 0.41171
174 4FVQ ATP 3.097e-06 0.41163
175 3TDV GDP 5.707e-06 0.41162
176 4O1P ANP 5.117e-06 0.41152
177 3TXO 07U 1.047e-07 0.41149
178 3VRY B43 8.875e-05 0.41105
179 4IVC 1J6 7.11e-06 0.41073
180 3TM0 ANP 0.0004377 0.4106
181 2H8H H8H 3.502e-06 0.41029
182 4OAV ACP 3.98e-06 0.40984
183 4ASE AV9 3.307e-05 0.40904
184 4IVB 1J5 4.356e-06 0.40796
185 3FHR P4O 9.399e-06 0.40767
186 2ZV2 609 2.901e-07 0.40732
187 1Q8Y ADE 4.22e-06 0.40709
188 3RE4 TO1 5.552e-06 0.40491
189 1BYG STU 2.604e-06 0.40475
190 4I94 ANP 7.195e-06 0.40423
191 2X2M X2M 2.7e-05 0.40413
192 3NW7 LGV 0.001034 0.40412
193 4BBF O19 3.31e-06 0.40251
194 3HAV ATP 4.619e-05 0.40195
195 4F9C 0SX 1.842e-06 0.40061
196 4NFN 2KC 2.994e-07 0.40058
197 4JQE ANP 1.322e-06 0.40036
198 4CTB KVC 6.386e-06 0.4002
199 4CQE CQE 1.127e-05 0.40002
200 2VZ6 FEF 6.962e-07 0.399
201 3BRB ADP 5.899e-06 0.39885
202 3A8W ATP 1.155e-05 0.39839
203 4KS7 X4Z 4.617e-05 0.39831
204 3ZRM ZRM 2.6e-06 0.39743
205 1OPK P16 1.604e-05 0.39686
206 2V58 LZJ 0.004587 0.39646
207 2QU6 857 3.375e-05 0.39632
208 4BCM T7Z 1.97e-06 0.39396
209 3LKM AMP 0.0001095 0.39378
210 2OID ANP 5.279e-06 0.39368
211 3A7H ATP 7.7e-06 0.39367
212 3KN5 ANP 1.338e-06 0.3936
213 3T7A ADP 0.002634 0.39348
214 4K77 1Q4 5.318e-06 0.39314
215 4F9B 0SY 4.949e-07 0.39281
216 4FOB 0US 3.458e-05 0.39196
217 1ZY5 ANP 1.497e-06 0.39176
218 1ZP9 ATP 1.214e-05 0.39117
219 4CMT GWH 4.921e-05 0.39104
220 4DCE 0JF 4.51e-05 0.39091
221 2WXG ZZN 0.0005267 0.39026
222 3TTI KBI 5.662e-05 0.38999
223 4E4L 0NH 1.33e-05 0.38989
224 4CCU AWF 1.332e-05 0.38921
225 3KAL ADP 0.009087 0.3891
226 3DAK ANP 5.179e-06 0.38894
227 4PU5 ANP 0.0002016 0.38735
228 1ZTH ADP 5.444e-06 0.38607
229 4H3P ANP 1.183e-05 0.38604
230 4OCV ANP 8.841e-05 0.38598
231 2A19 ANP 9.71e-07 0.38586
232 4EWH T77 4.075e-05 0.38501
233 1PK8 ATP 0.0005915 0.38486
234 4KWP EXX 9.633e-08 0.38426
235 3BE2 RAJ 0.000175 0.384
236 4GRB 0XG 2.787e-07 0.38391
237 1IA9 ANP 0.0001774 0.38355
238 3DNT ATP 0.0002855 0.38351
239 4UXQ 0LI 0.001042 0.38315
240 3QUP LUN 3.392e-05 0.3826
241 3SXS PP2 9.845e-05 0.38211
242 4LRJ ANP 1.59e-05 0.38173
243 3ZBF VGH 1.507e-05 0.38155
244 3OWL 19E 1.562e-08 0.38147
245 4CYI ATP 6.785e-05 0.38127
246 4C2W ANP 5.986e-06 0.38043
247 4EHZ JAK 6.398e-06 0.37993
248 4FK6 0UJ 3.941e-05 0.37986
249 4ORK GDP 3.489e-05 0.37916
250 3VPB ADP 0.00226 0.37887
251 4X2J 3WN 1.643e-05 0.37832
252 4X2K 3WO 1.643e-05 0.37832
253 4AZW ATP 0.0001198 0.37804
254 3GC8 B45 0.0001049 0.37797
255 2P2H 994 1.714e-05 0.37792
256 4F0F ACP 1.56e-05 0.37756
257 2P2I 608 0.0002518 0.37731
258 2VN9 GVD 5.379e-07 0.37683
259 4KNB 1RU 0.0001129 0.37674
260 4CLI 5P8 2.619e-05 0.37673
261 4CCB OFG 2.105e-05 0.37585
262 4BFM ANP 9.292e-05 0.37532
263 4G16 0VM 2.322e-05 0.37517
264 4EI4 0Q2 2.37e-05 0.37408
265 4GYI ADP 3.611e-05 0.37249
266 2BKK ADP 4.399e-05 0.37228
267 4PMT 31Y 0.0001046 0.37215
268 1I7L ATP 0.0001632 0.37153
269 3BU5 ATP 9.547e-06 0.37131
270 2Y6O 1N1 0.0002681 0.37052
271 4I6H 1C8 0.0001123 0.37046
272 3FI3 JK2 0.002747 0.37002
273 4CTC J99 6.907e-05 0.36969
274 3OFM 4B0 8.018e-09 0.36952
275 3ZOS 0LI 0.0119 0.36942
276 2PUL ACP 0.0002014 0.36911
277 3C0G 3AM 9.515e-08 0.36867
278 2HK5 1BM 0.0001244 0.36833
279 2PYW ADP 0.0001144 0.36802
280 2IO8 ADP 0.001332 0.36625
281 3AKK ADP 0.0001664 0.36599
282 1Z2P ACP 0.006832 0.36428
283 3GC0 AMP 2.477e-05 0.36371
284 4DC2 ADE 3.194e-07 0.36289
285 3OWK 18E 3.252e-08 0.3624
286 4CLJ 5P8 0.000176 0.36215
287 4KBA 1QM 0.0001229 0.36147
288 3C1X CKK 0.00134 0.36111
289 3PDT ADP 0.0004799 0.36098
290 4O4F ATP 0.003918 0.36078
291 4CMO YPW 9.971e-05 0.36068
292 2Q7D ANP 0.002756 0.36056
293 4CKR DI1 0.001268 0.36039
294 3PTG 932 3.063e-06 0.35915
295 1MQB ANP 2.18e-05 0.35848
296 4LOO SB4 0.0005057 0.35821
297 4TW9 386 0.0002622 0.3582
298 2OO8 RAJ 0.002244 0.35809
299 3TPV ADE 0.001568 0.3575
300 3HZT J60 1.193e-05 0.35716
301 3UDZ ADP 0.0005965 0.35684
302 4BCQ TJF 1.425e-05 0.35672
303 2WEI VGG 0.0001059 0.356
304 4G17 0VN 0.0002387 0.35549
305 3UZP 0CK 4.955e-05 0.35541
306 4CMU IV7 0.0001052 0.35534
307 4BBE 3O4 1.282e-05 0.35482
308 3RGF BAX 0.002356 0.35462
309 4FOC 0UU 0.0001942 0.35461
310 1IOW ADP 0.01831 0.35445
311 3UYT 0CK 0.0001378 0.35421
312 3C0H AMP 2.073e-07 0.35411
313 2NRU T12 0.0002622 0.35389
314 4AU8 Z3R 2.908e-05 0.35374
315 3Q60 ATP 0.0003166 0.35369
316 4C58 824 0.02895 0.3533
317 4O2B ACP 0.002039 0.35323
318 1EHI ADP 0.001612 0.35271
319 2YW2 ATP 0.001322 0.35249
320 3U6H 03X 0.0208 0.35112
321 3ETH ATP 0.003829 0.3505
322 3VPC ADP 0.002751 0.35032
323 4PMM 31V 0.000888 0.35027
324 4TWC 37J 0.0006871 0.34974
325 2WQN ADP 6.737e-05 0.34894
326 4FHD EEM 0.02256 0.34858
327 2VPQ ANP 0.006293 0.34831
328 4NJH 2K8 0.02027 0.34814
329 1K3A ACP 4.793e-05 0.34711
330 3EFK MT4 0.004763 0.34694
331 3RYC GTP 0.01524 0.34608
332 3WVR AMP 0.001708 0.34541
333 3V4S ATP 0.0407 0.34537
334 2O2U 738 2.566e-05 0.34491
335 3VOT ADP 0.0008182 0.34459
336 2VQD AP2 0.005757 0.34397
337 4KBC 1QJ 7.478e-06 0.3439
338 4DRX GTP 0.01775 0.34327
339 2AQX ATP 0.005009 0.34313
340 2ZM3 575 0.0002414 0.34287
341 2OXY K17 1.65e-07 0.34274
342 4EYM 0RX 0.001348 0.34183
343 3WAR NIO 7.16e-09 0.34078
344 2RFN AM7 0.00248 0.34017
345 4PMP 31W 0.0007778 0.34007
346 4CNH 3U9 5.326e-05 0.33954
347 1WBP ADP 3.246e-05 0.3391
348 3H9R TAK 0.0003002 0.33831
349 4F1M ACP 0.0003775 0.33766
350 3V4S ADP 0.0456 0.33762
351 4HNF 16W 6.072e-05 0.33744
352 4BKJ STI 0.007883 0.33453
353 2CFM AMP 0.001341 0.33357
354 4UWH JXM 0.002032 0.33319
355 3ORQ ADP 0.01 0.33281
356 3MB6 01I 7.153e-07 0.33157
357 3TY5 ADP 0.003006 0.33069
358 3PN1 IVH 0.002599 0.32922
359 1W2D 4IP 0.02763 0.32917
360 2PZI AXX 0.001114 0.32873
361 3KMW ATP 0.004966 0.32806
362 4CC5 L5V 0.00199 0.32791
363 4X0M 3WA 3.504e-05 0.32787
364 4RLL E91 9.862e-06 0.327
365 4K38 SAM 0.01617 0.32545
366 2WEL K88 2.081e-05 0.32504
367 4DEH 0JK 0.002041 0.32484
368 1CKN GTP 0.003577 0.32438
369 4K39 SAM 0.01714 0.32331
370 4F1O ACP 0.001252 0.32271
371 1CKM GTP 0.006123 0.3226
372 1S68 AMP 0.003246 0.32239
373 3I0O ADP 0.004494 0.32238
374 3KDJ A8S 0.02342 0.32127
375 3TY5 ATP 0.001862 0.32113
376 2GQS C2R 0.007917 0.32039
377 4JPS 1LT 0.006231 0.31991
378 4P5E N6P 0.02811 0.31885
379 4K37 SAM 0.01658 0.31867
380 3TII ANP 0.004523 0.31767
381 4AZT LY2 0.00891 0.31682
382 3JRS A8S 0.02943 0.31603
383 1GT4 UNA 0.02202 0.31396
384 4OCT AKG 0.02013 0.31373
385 3PFF ADP 0.0222 0.31218
386 4LH7 1X8 0.000895 0.31147
387 3AQV TAK 0.004952 0.31117
388 3ZEU AGS 0.04874 0.31112
389 1PMO PLR 0.04913 0.30945
390 3ZEU ADP 0.03353 0.30939
391 2QK4 ATP 0.003265 0.30936
392 2IF8 ADP 0.001392 0.30911
393 2QLU ADE 0.0004071 0.30671
394 4ITH RCM 0.04502 0.30612
395 3AHW 2AM 0.01966 0.3056
396 4AVB CMP 0.03755 0.30533
397 3OCP CMP 0.006719 0.30478
398 2GQR ADP 0.03492 0.30432
399 4DFU QUE 0.003432 0.30306
400 3NMV PYV 0.0219 0.30149
401 4AUA 4AU 0.0007734 0.29973
402 3GXZ NAG 0.04422 0.29951
403 3SLS 77D 0.03567 0.29844
404 2ZBA ZBA 0.01377 0.29829
405 2X24 X24 0.04633 0.29778
406 2VK2 GZL 0.03052 0.29628
407 4J25 OGA 0.0246 0.29545
408 1T74 DHT 0.04022 0.29487
409 4IRX INS 0.04824 0.29462
410 4GLW 0XT 0.007489 0.2921
411 1TZD ADP 0.00592 0.29171
412 4PZ6 GMP 0.003865 0.29048
413 1ZDQ MSM 0.02967 0.29029
414 3ZJX BOG 0.002592 0.28947
415 4G31 0WH 0.0006222 0.28894
416 3JQ9 AX1 0.04845 0.28857
417 2P7Q GG6 0.02591 0.28608
418 1Z03 OCH 0.04136 0.28601
419 1JPA ANP 0.001176 0.2857
420 1OAU SER 0.03508 0.28518
421 2E40 LGC 0.04312 0.28405
422 1A4K FRA 0.02034 0.28364
423 1LOP SIN 0.02855 0.27956
424 3QBC B55 0.02889 0.27803
425 3M8T 4NZ 0.04416 0.27782
426 3T0W DIW 0.04033 0.27657
427 4B1L FRU 0.0105 0.27529
428 3R4S SLB 0.01443 0.26985
429 2ZL7 FUC 0.04872 0.26965
430 2QL9 CIT 0.04645 0.26815
431 3W9F I3P 0.01923 0.26726
432 4NST AF3 4.742e-07 0.26429
433 1HFU NAG 0.01236 0.26227
434 3MBC NAP 0.0422 0.25934
435 1PVC ILE 0.005065 0.25851
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