Receptor
PDB id Resolution Class Description Source Keywords
2w97 2.29 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF EIF4E BOUND TO GLYCEROL AND EIF4G1 PEPT HOMO SAPIENS PROTEIN BIOSYNTHESIS INITIATION FACTOR TRANSLATION REGULATTRANSLATION
Ref.: CRYSTALLIZATION OF EIF4E COMPLEXED WITH EIF4GI PEPT GLYCEROL REVEALS DISTINCT STRUCTURAL DIFFERENCES AR CAP-BINDING SITE. CELL CYCLE V. 8 1905 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:1222;
B:1220;
 Invalid;
Invalid;
 none;
none;
 submit data
92.094 C3 H8 O3 C(C(C...
MGO A:1218;
 Valid;
 none;
 Kd ~ 9 nM
537.227 C12 H20 N4 O14 P3 C[n+]...
PGE A:1219;
 Invalid;
 none;
 submit data
150.173 C6 H14 O4 C(COC...
SO4 A:1220;
A:1221;
B:1218;
B:1219;
 Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
 submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2W97 2.29 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF EIF4E BOUND TO GLYCEROL AND EIF4G1 PEPT HOMO SAPIENS PROTEIN BIOSYNTHESIS INITIATION FACTOR TRANSLATION REGULATTRANSLATION
Ref.: CRYSTALLIZATION OF EIF4E COMPLEXED WITH EIF4GI PEPT GLYCEROL REVEALS DISTINCT STRUCTURAL DIFFERENCES AR CAP-BINDING SITE. CELL CYCLE V. 8 1905 2009
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 308 families.
1 2W97 Kd ~ 9 nM MGO C12 H20 N4 O14 P3 C[n+]1cn(c....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 266 families.
1 2W97 Kd ~ 9 nM MGO C12 H20 N4 O14 P3 C[n+]1cn(c....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 220 families.
1 2W97 Kd ~ 9 nM MGO C12 H20 N4 O14 P3 C[n+]1cn(c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: MGO; Similar ligands found: 34
No: Ligand ECFP6 Tc MDL keys Tc
1 MGO 1 1
2 MGP 0.619565 0.901235
3 6G0 0.612903 0.901235
4 QBQ 0.541667 0.851852
5 CZF 0.5 0.873418
6 GTP 0.5 0.864198
7 ATP 0.474227 0.860759
8 HEJ 0.474227 0.860759
9 5FA 0.469388 0.860759
10 AQP 0.469388 0.860759
11 G7M 0.46875 0.888889
12 GTG 0.468468 0.879518
13 JSQ 0.46 0.819277
14 HFD 0.46 0.819277
15 GTA 0.45614 0.879518
16 7DT 0.454545 0.848101
17 ITT 0.44898 0.835443
18 GP3 0.445545 0.843373
19 GDP 0.441176 0.864198
20 B4P 0.428571 0.8375
21 AP5 0.428571 0.8375
22 GSP 0.420561 0.823529
23 BA3 0.418367 0.8375
24 ADP 0.414141 0.860759
25 A2D 0.412371 0.8375
26 G1R 0.411215 0.853659
27 GNH 0.409524 0.853659
28 6AD 0.409524 0.833333
29 IDP 0.407767 0.8625
30 25L 0.40708 0.85
31 6YZ 0.401869 0.839506
32 GAV 0.4 0.833333
33 01G 0.4 0.786517
34 RGT 0.4 0.829268
Similar Ligands (3D)
Ligand no: 1; Ligand: MGO; Similar ligands found: 6
No: Ligand Similarity coefficient
1 MGT 0.9906
2 M7G 0.9132
3 ACP 0.9077
4 ANP 0.8925
5 GNP 0.8726
6 ADP BEF 0.8672
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2W97; Ligand: MGO; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2w97.bio1) has 15 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback