Receptor
PDB id Resolution Class Description Source Keywords
2g5u 1.8 Å NON-ENZYME: TRANSPORT HUMAN TRANSTHYRETIN (TTR) COMPLEXED WITH HYDROXYLATED POLYCH BIPHENYL-4,4'-DIHYDROXY-3,3',5,5'-TETRACHLOROBIPHENYL HOMO SAPIENS TTR AMYLOID TRANSTHYRETIN HORMONE-GROWTH FACTOR COMPLEX
Ref.: HYDROXYLATED POLYCHLORINATED BIPHENYLS SELECTIVELY TRANSTHYRETIN IN BLOOD AND INHIBIT AMYLOIDOGENESIS: RATIONALIZING RODENT PCB TOXICITY CHEM.BIOL. V. 11 1719 2004
Ligand Information
Ligand Validity Binding Data Ligand Warnings Chemaxon Viewer Molecular Weight (Da) Formula SMILES
PCQ Valid Kd = 3.2 nM none 323.987
C12 H6 Cl4 O2
c1c(cc(c(c1Cl)O)Cl)c2cc(c(c(c2)Cl)O)Cl
90% Homology Family

The Class containing this family consists of a total of 164 families.

Leader:    2G5U     HUMAN TRANSTHYRETIN (TTR) COMPLEXED WITH HYDROXYLATED POLYCH BIPHENYL-4,4'-DIHYDROXY-3,3',5,5'-TETRACHLOROBIPHENYL
No: PDB id Binding Data Representative ligand
1 1TLM - MIL
2 2QGD - MR5
3 2B16 - DNF
4 4ABV ic50 = 0.85 uM FT2
5 3ESO - DZ2
6 3GLZ - 1BD
7 2G9K - NE1
8 2FLM - 6CA
9 3IMU - IW4
10 4ABU ic50 = 0.52 uM FT1
11 2G5U Kd = 3.2 nM PCQ
12 3NEX - G24
13 4DER ic50 = 10.3 uM AGI
14 3CN3 - LJ4
15 3GS4 - 7BD
16 3IPB ic50 = 0.2 uM JZD
17 1THA - T33
18 1F86 - T44
19 1TYR Kd = 0.1 uM REA
20 1DVY - BPD
21 4AC2 - 43F
22 3NEE - B72
23 3GS7 - 8BD
24 4DEU ic50 = 12.39 uM NAR
25 3IMR - IW1
26 3KGU Kd = 1.2 uM GEN
27 3ESP - DZ3
28 1BM7 Kd = 30 nM FLF
29 1DVU - DBF
30 3TCT Kd = 2 nM 3MI
31 2FBR - 44C
32 1U21 Kd = 5 nM P2C
33 2QGC - MR4
34 2B77 - 3CA
35 2F7I - 26C
36 1E4H Kd = 3.9 nM PBR
37 3CN4 - LJ5
38 3IMV - IW5
39 2GAB - NE2
40 3CN0 - LJ1
41 3GS0 - 6BD
42 1DVX - DIF
43 3M1O - CJZ
44 3FCB ic50 = 4.9 uM IFB
45 1DVT - FLP
46 2ROX - T44
47 3IMS - IW2
48 4DET ic50 = 8.26 uM KMP
49 3FC8 ic50 = 4.1 uM IFA
50 3D2T Kd = 1100 nM 1FL
51 1E5A Kd = 23 nM TBP
52 3KGT Kd = 3.1 uM GEN
53 3CFT Kd = 64 uM 5NS
54 1ETA - T44
55 3IMW - IW6
56 1THC - FL9
57 2QGE - MR6
58 3IPE ic50 = 0.15 uM JZE
59 1TZ8 - DES
60 4ABW - 42M
61 1Z7J - T4A
62 2B15 - DNF
63 3CN1 - LJ2
64 2F8I - 205
65 1DVZ Kd = 78 nM OFL
66 2B9A - FBC
67 3CFQ - DIF
68 1DVS - STL
69 3NEO - G24
70 3IMT - IW3
71 2ROY - P28
72 1TT6 - DES
73 3ESN - DZ1
74 3B56 - DIU
75 3NG5 - KDH
76 1Y1D - FHI
77 3CN2 - LJ3
78 4DES ic50 = 12.16 uM 57D
79 1ETB - T44
80 2B14 - DNF
81 4ABQ - 4V2
82 3NES - B72
83 3CFN Kd = 4.3 uM 2AN
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