Receptor
PDB id Resolution Class Description Source Keywords
2adu 1.9 Å EC: 3.4.11.18 HUMAN METHIONINE AMINOPEPTIDASE COMPLEX WITH 4-ARYL-1,2,3-TR INHIBITOR HOMO SAPIENS HYDROLASE AMINOPEPTIDASE METAL BINDING PROTEASE
Ref.: 4-ARYL-1,2,3-TRIAZOLE: A NOVEL TEMPLATE FOR A REVER METHIONINE AMINOPEPTIDASE 2 INHIBITOR, OPTIMIZED TO ANGIOGENESIS IN VIVO J.MED.CHEM. V. 48 5644 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CO A:501;
A:502;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
58.933 Co [Co+2...
R20 A:906;
 Valid;
 none;
 Ki = 18 nM
159.188 C9 H9 N3 Cc1cc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
7A16 1.9 Å EC: 3.4.11.18 CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN CO AN INHIBITOR GSK2229238A (COMPOUND 43) HOMO SAPIENS METHIONINE AMINOPEPTIDASE-2 HYDROLASE
Ref.: STRUCTURE-BASED OPTIMISATION OF ORALLY ACTIVE & REV METAP-2 INHIBITORS MAINTAINING A TIGHT 'MOLECULAR B BIOORG.MED.CHEM.LETT. V. 30 27533 2020
Members (26)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 2GA2 ic50 = 3 uM A19 C13 H9 Br Cl N O4 S c1cc(ccc1S....
2 2ADU Ki = 18 nM R20 C9 H9 N3 Cc1cccc(c1....
3 7A14 ic50 = 0.00000001 M QVB C18 H16 Cl F N2 O2 CC(C)Oc1cc....
4 6QEI - HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
5 6QEF ic50 = 0.06 uM HZW C18 H16 Cl F N2 O3 c1ccc(cc1)....
6 6QEJ - HZT C14 H13 F N4 O2 S2 c1cc(sc1)S....
7 6QEH - HZQ C9 H6 Cl N O c1cc2c(ccc....
8 7A12 ic50 = 0.00000001 M QVK C15 H11 Cl N2 O c1ccc(cc1)....
9 7A16 ic50 = 0.00000001 M HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
10 1R58 - AO5 C15 H22 Cl N3 O3 S CC(C)SCC[C....
11 5JHU - 6KO C18 H19 N5 O3 COc1ccccc1....
12 1YW9 ic50 = 0.019 uM A84 C22 H25 F N2 O4 S CN(C)CC=C/....
13 2EA2 ic50 = 0.016 uM F77 C16 H16 F N O4 S CCc1ccc(c(....
14 7A15 ic50 = 0.00000001 M QV5 C22 H24 Cl F N4 O2 CC(C)Oc1cc....
15 6QEG ic50 = 0.05 uM K4K C17 H18 N2 O3 S c1ccc(cc1)....
16 5LYX ic50 = 0.038 uM 7BF C19 H18 N6 O c1cc2cnccc....
17 5JI6 ic50 = 0.011 uM 6KN C14 H10 F3 N3 Cc1cnccc1c....
18 5JFR ic50 = 5 nM 6KP C16 H11 F N6 Cc1c(cc2c(....
19 5LYW ic50 = 0.7 uM 7BH C17 H19 N5 O Cc1ccccc1O....
20 1R5H ic50 = 0.17 uM AO2 C17 H27 N3 O2 Cc1ccc(cc1....
21 1YW7 ic50 = 1.4 uM A41 C14 H13 N O4 S Cc1ccc(c(c....
22 7A13 - QW5 C16 H13 Cl N2 O2 COc1cccc(c....
23 2EA4 ic50 = 0.046 uM F79 C17 H19 F N2 O5 S CCc1ccc(c(....
24 1R5G - AO1 C19 H26 N2 O2 S CCSCC[C@@H....
25 6QED ic50 = 0.015 uM HZK C21 H19 Cl F N3 O4 c1cc2c(cc1....
26 2OAZ Ki = 2 nM I96 C16 H18 N4 S2 CC(C)c1ccc....
70% Homology Family (29)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2GA2 ic50 = 3 uM A19 C13 H9 Br Cl N O4 S c1cc(ccc1S....
2 2ADU Ki = 18 nM R20 C9 H9 N3 Cc1cccc(c1....
3 7A14 ic50 = 0.00000001 M QVB C18 H16 Cl F N2 O2 CC(C)Oc1cc....
4 6QEI - HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
5 6QEF ic50 = 0.06 uM HZW C18 H16 Cl F N2 O3 c1ccc(cc1)....
6 6QEJ - HZT C14 H13 F N4 O2 S2 c1cc(sc1)S....
7 6QEH - HZQ C9 H6 Cl N O c1cc2c(ccc....
8 7A12 ic50 = 0.00000001 M QVK C15 H11 Cl N2 O c1ccc(cc1)....
9 7A16 ic50 = 0.00000001 M HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
10 1R58 - AO5 C15 H22 Cl N3 O3 S CC(C)SCC[C....
11 5JHU - 6KO C18 H19 N5 O3 COc1ccccc1....
12 1YW9 ic50 = 0.019 uM A84 C22 H25 F N2 O4 S CN(C)CC=C/....
13 2EA2 ic50 = 0.016 uM F77 C16 H16 F N O4 S CCc1ccc(c(....
14 7A15 ic50 = 0.00000001 M QV5 C22 H24 Cl F N4 O2 CC(C)Oc1cc....
15 6QEG ic50 = 0.05 uM K4K C17 H18 N2 O3 S c1ccc(cc1)....
16 5LYX ic50 = 0.038 uM 7BF C19 H18 N6 O c1cc2cnccc....
17 5JI6 ic50 = 0.011 uM 6KN C14 H10 F3 N3 Cc1cnccc1c....
18 5JFR ic50 = 5 nM 6KP C16 H11 F N6 Cc1c(cc2c(....
19 5LYW ic50 = 0.7 uM 7BH C17 H19 N5 O Cc1ccccc1O....
20 1R5H ic50 = 0.17 uM AO2 C17 H27 N3 O2 Cc1ccc(cc1....
21 1YW7 ic50 = 1.4 uM A41 C14 H13 N O4 S Cc1ccc(c(c....
22 7A13 - QW5 C16 H13 Cl N2 O2 COc1cccc(c....
23 2EA4 ic50 = 0.046 uM F79 C17 H19 F N2 O5 S CCc1ccc(c(....
24 1R5G - AO1 C19 H26 N2 O2 S CCSCC[C@@H....
25 6QED ic50 = 0.015 uM HZK C21 H19 Cl F N3 O4 c1cc2c(cc1....
26 2OAZ Ki = 2 nM I96 C16 H18 N4 S2 CC(C)c1ccc....
27 1KQ9 - MET C5 H11 N O2 S CSCC[C@@H]....
28 1KQ0 - MED C5 H11 N O2 S CSCC[C@H](....
29 1QZY ic50 ~ 800 nM TDE C18 H32 N2 O7 CC(C)(C)C=....
50% Homology Family (29)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2GA2 ic50 = 3 uM A19 C13 H9 Br Cl N O4 S c1cc(ccc1S....
2 2ADU Ki = 18 nM R20 C9 H9 N3 Cc1cccc(c1....
3 7A14 ic50 = 0.00000001 M QVB C18 H16 Cl F N2 O2 CC(C)Oc1cc....
4 6QEI - HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
5 6QEF ic50 = 0.06 uM HZW C18 H16 Cl F N2 O3 c1ccc(cc1)....
6 6QEJ - HZT C14 H13 F N4 O2 S2 c1cc(sc1)S....
7 6QEH - HZQ C9 H6 Cl N O c1cc2c(ccc....
8 7A12 ic50 = 0.00000001 M QVK C15 H11 Cl N2 O c1ccc(cc1)....
9 7A16 ic50 = 0.00000001 M HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
10 1R58 - AO5 C15 H22 Cl N3 O3 S CC(C)SCC[C....
11 5JHU - 6KO C18 H19 N5 O3 COc1ccccc1....
12 1YW9 ic50 = 0.019 uM A84 C22 H25 F N2 O4 S CN(C)CC=C/....
13 2EA2 ic50 = 0.016 uM F77 C16 H16 F N O4 S CCc1ccc(c(....
14 7A15 ic50 = 0.00000001 M QV5 C22 H24 Cl F N4 O2 CC(C)Oc1cc....
15 6QEG ic50 = 0.05 uM K4K C17 H18 N2 O3 S c1ccc(cc1)....
16 5LYX ic50 = 0.038 uM 7BF C19 H18 N6 O c1cc2cnccc....
17 5JI6 ic50 = 0.011 uM 6KN C14 H10 F3 N3 Cc1cnccc1c....
18 5JFR ic50 = 5 nM 6KP C16 H11 F N6 Cc1c(cc2c(....
19 5LYW ic50 = 0.7 uM 7BH C17 H19 N5 O Cc1ccccc1O....
20 1R5H ic50 = 0.17 uM AO2 C17 H27 N3 O2 Cc1ccc(cc1....
21 1YW7 ic50 = 1.4 uM A41 C14 H13 N O4 S Cc1ccc(c(c....
22 7A13 - QW5 C16 H13 Cl N2 O2 COc1cccc(c....
23 2EA4 ic50 = 0.046 uM F79 C17 H19 F N2 O5 S CCc1ccc(c(....
24 1R5G - AO1 C19 H26 N2 O2 S CCSCC[C@@H....
25 6QED ic50 = 0.015 uM HZK C21 H19 Cl F N3 O4 c1cc2c(cc1....
26 2OAZ Ki = 2 nM I96 C16 H18 N4 S2 CC(C)c1ccc....
27 1KQ9 - MET C5 H11 N O2 S CSCC[C@@H]....
28 1KQ0 - MED C5 H11 N O2 S CSCC[C@H](....
29 1QZY ic50 ~ 800 nM TDE C18 H32 N2 O7 CC(C)(C)C=....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: R20; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 R20 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: R20; Similar ligands found: 1113
No: Ligand Similarity coefficient
1 L5V 0.9987
2 6TZ 0.9971
3 HQJ 0.9963
4 XDK 0.9830
5 ONR 0.9735
6 M1Z 0.9733
7 M3H 0.9720
8 PIM 0.9708
9 4V2 0.9696
10 4PN 0.9693
11 PIY 0.9691
12 L22 0.9688
13 GZ2 0.9653
14 MPV 0.9644
15 N3W 0.9638
16 IWT 0.9633
17 BNL 0.9606
18 52C 0.9604
19 2F6 0.9603
20 PO6 0.9601
21 0F9 0.9591
22 0BP 0.9590
23 TT4 0.9585
24 A29 0.9584
25 J9Q 0.9575
26 97T 0.9563
27 NCT 0.9552
28 BZE 0.9550
29 HX4 0.9549
30 7VP 0.9544
31 CH9 0.9527
32 795 0.9526
33 7MU 0.9523
34 MSR 0.9522
35 D3G 0.9519
36 PPY 0.9508
37 492 0.9502
38 BPY 0.9498
39 069 0.9494
40 GVG 0.9493
41 CPZ 0.9491
42 HJH 0.9490
43 HIS 0.9486
44 ALE 0.9484
45 4XF 0.9479
46 0W1 0.9472
47 X48 0.9470
48 SNU 0.9465
49 T2D 0.9464
50 2HC 0.9459
51 EWG 0.9459
52 TZF 0.9458
53 J9T 0.9458
54 BP7 0.9451
55 P80 0.9451
56 TCA 0.9447
57 1A7 0.9441
58 R2P 0.9441
59 DHI 0.9440
60 AY4 0.9440
61 A5E 0.9437
62 BZ2 0.9425
63 JG8 0.9422
64 JRB 0.9421
65 46P 0.9419
66 AOT 0.9418
67 LNR 0.9414
68 L99 0.9412
69 61M 0.9410
70 PJW 0.9410
71 45L 0.9403
72 36Y 0.9403
73 C1M 0.9403
74 M45 0.9402
75 AX3 0.9401
76 JF6 0.9396
77 HCI 0.9395
78 6FZ 0.9393
79 TIH 0.9390
80 ICB 0.9385
81 363 0.9385
82 M5H 0.9384
83 4WL 0.9382
84 N2Z 0.9381
85 9CA 0.9380
86 4ZA 0.9380
87 1IT 0.9379
88 XYH 0.9377
89 KTA 0.9374
90 QUS 0.9369
91 ESX 0.9368
92 9FL 0.9367
93 K34 0.9367
94 KW8 0.9364
95 VXX 0.9361
96 5F5 0.9360
97 0HN 0.9359
98 2ZM 0.9358
99 KTW 0.9356
100 HA5 0.9356
101 AKG 0.9355
102 S2G 0.9353
103 LEL 0.9352
104 3NY 0.9350
105 1WC 0.9350
106 0HO 0.9346
107 VM1 0.9345
108 4P5 0.9344
109 3A9 0.9337
110 2AL 0.9337
111 1F1 0.9334
112 RKV 0.9332
113 CXH 0.9332
114 TZM 0.9331
115 D2G 0.9325
116 OGA 0.9322
117 PHU 0.9320
118 8NX 0.9318
119 YTX 0.9316
120 CFI 0.9316
121 XIZ 0.9311
122 6NT 0.9310
123 VNL 0.9308
124 463 0.9306
125 3C4 0.9306
126 6NI 0.9303
127 ABI 0.9303
128 2HG 0.9300
129 J9N 0.9300
130 15N 0.9299
131 0JD 0.9299
132 EXD 0.9298
133 ISZ 0.9298
134 GF4 0.9297
135 6Q3 0.9296
136 4BL 0.9294
137 0NX 0.9293
138 S2P 0.9290
139 SLS 0.9288
140 GO2 0.9288
141 DHB 0.9286
142 8WO 0.9284
143 X11 0.9282
144 2HU 0.9280
145 6RQ 0.9280
146 INO 0.9280
147 60L 0.9279
148 HIC 0.9279
149 FK8 0.9278
150 1L5 0.9276
151 4BY 0.9275
152 CK2 0.9273
153 ESI 0.9272
154 12T 0.9272
155 5NI 0.9272
156 1Z6 0.9271
157 263 0.9270
158 CHB 0.9270
159 PAC 0.9270
160 JAW 0.9269
161 IHB 0.9269
162 7O4 0.9267
163 K97 0.9265
164 2HO 0.9265
165 M3E 0.9262
166 GLN 0.9261
167 1XA 0.9261
168 F4E 0.9260
169 TYL 0.9259
170 MYJ 0.9257
171 3ZB 0.9255
172 E1T 0.9255
173 NYL 0.9255
174 BHO 0.9254
175 M4T 0.9253
176 CXP 0.9253
177 94W 0.9252
178 3PF 0.9250
179 LL1 0.9249
180 B4O 0.9249
181 URO 0.9247
182 4LW 0.9245
183 6QF 0.9245
184 QSB 0.9242
185 G3E 0.9241
186 ZME 0.9239
187 9ZE 0.9239
188 A9P 0.9239
189 AN3 0.9238
190 CWJ 0.9238
191 344 0.9236
192 XQI 0.9236
193 K80 0.9236
194 ANC 0.9234
195 AVA 0.9234
196 3C5 0.9232
197 J5I 0.9230
198 93K 0.9230
199 173 0.9227
200 F31 0.9226
201 PHE 0.9226
202 92G 0.9226
203 C53 0.9224
204 D48 0.9223
205 9FE 0.9223
206 P9P 0.9223
207 KJU 0.9223
208 SE2 0.9222
209 36E 0.9221
210 C82 0.9220
211 EN1 0.9219
212 FHB 0.9219
213 P7Y 0.9219
214 0LO 0.9218
215 CK1 0.9218
216 HHI 0.9218
217 9TW 0.9217
218 7BC 0.9217
219 GAB 0.9216
220 5GU 0.9216
221 ESP 0.9216
222 4NC 0.9215
223 JDN 0.9212
224 HNL 0.9212
225 NIZ 0.9211
226 KTJ 0.9209
227 9UL 0.9206
228 NNO 0.9206
229 4LV 0.9206
230 4A3 0.9205
231 ES2 0.9202
232 92P 0.9196
233 NF3 0.9196
234 UNJ 0.9196
235 8OZ 0.9191
236 FBM 0.9189
237 RA7 0.9188
238 GZL 0.9188
239 268 0.9188
240 EYV 0.9187
241 428 0.9186
242 Z5P 0.9184
243 YZM 0.9184
244 NFA 0.9181
245 5VL 0.9179
246 FUD 0.9174
247 I1E 0.9174
248 BCU 0.9173
249 5F8 0.9170
250 78Y 0.9169
251 SAF 0.9169
252 OMD 0.9169
253 H4E 0.9166
254 X0W 0.9166
255 C2Y 0.9165
256 2O6 0.9164
257 N2I 0.9164
258 J6W 0.9164
259 E35 0.9163
260 8NB 0.9162
261 XIY 0.9162
262 HSO 0.9161
263 5XC 0.9161
264 5FL 0.9160
265 DE5 0.9159
266 1X4 0.9158
267 4FH 0.9157
268 PZI 0.9156
269 5TZ 0.9155
270 1VK 0.9155
271 X0V 0.9155
272 OVV 0.9153
273 ASC 0.9151
274 GLU 0.9151
275 8ZE 0.9150
276 PRZ 0.9150
277 HGA 0.9147
278 15E 0.9147
279 R1P 0.9146
280 N7I 0.9145
281 DIR 0.9143
282 3HM 0.9143
283 HDH 0.9142
284 JP2 0.9140
285 3HP 0.9140
286 EOL 0.9139
287 JLZ 0.9139
288 HNH 0.9137
289 DHC 0.9136
290 F9P 0.9136
291 AVI 0.9132
292 X0U 0.9131
293 G14 0.9131
294 7UZ 0.9130
295 DGL 0.9129
296 2IT 0.9129
297 DGN 0.9128
298 CIY 0.9128
299 JA8 0.9128
300 7ZL 0.9128
301 3HB 0.9128
302 2LY 0.9124
303 XX2 0.9123
304 MXD 0.9123
305 L14 0.9123
306 DNF 0.9123
307 HFA 0.9123
308 5QY 0.9122
309 X6P 0.9121
310 JB8 0.9120
311 3QM 0.9119
312 XCG 0.9118
313 3AB 0.9116
314 92K 0.9115
315 GDE 0.9114
316 3OC 0.9114
317 QMP 0.9113
318 EDR 0.9113
319 SHI 0.9113
320 HNK 0.9111
321 PRO GLY 0.9110
322 6J9 0.9110
323 GVY 0.9109
324 FHC 0.9109
325 RUY 0.9109
326 OVM 0.9108
327 E7S 0.9108
328 PH3 0.9108
329 DHK 0.9108
330 3YP 0.9106
331 BQ2 0.9104
332 30G 0.9104
333 TSR 0.9103
334 7OD 0.9103
335 SSC 0.9102
336 JFJ 0.9102
337 4JQ 0.9102
338 3QV 0.9101
339 LJ3 0.9101
340 TMG 0.9101
341 HC4 0.9101
342 IOS 0.9095
343 L03 0.9094
344 B40 0.9094
345 1M2 0.9094
346 PRA 0.9093
347 ONL 0.9092
348 A3M 0.9092
349 7WR 0.9091
350 WCE 0.9091
351 3BZ 0.9091
352 4SX 0.9090
353 U7E 0.9088
354 1P8 0.9088
355 5LD 0.9086
356 HPS 0.9086
357 8XL 0.9086
358 2BG 0.9086
359 GJZ 0.9086
360 R9Y 0.9084
361 PEY 0.9083
362 KDG 0.9083
363 OW4 0.9083
364 GOJ 0.9082
365 N9J 0.9081
366 4ME 0.9081
367 DHY 0.9081
368 4MU 0.9079
369 KMH 0.9078
370 8U3 0.9077
371 XDE 0.9077
372 L13 0.9077
373 SKM 0.9076
374 M4E 0.9075
375 F16 0.9075
376 QSH 0.9074
377 NMJ 0.9074
378 6KT 0.9073
379 8WT 0.9073
380 5OB 0.9073
381 AHN 0.9072
382 3BU 0.9072
383 IAC 0.9072
384 TPA 0.9071
385 LT2 0.9070
386 FEH 0.9069
387 FF2 0.9069
388 HL5 0.9069
389 V2Z 0.9068
390 9PL 0.9066
391 ZYR 0.9065
392 PUE 0.9064
393 DIN 0.9064
394 CFA 0.9063
395 2FQ 0.9062
396 FBB 0.9061
397 4I8 0.9058
398 3NT 0.9056
399 KYA 0.9055
400 ZZA 0.9055
401 2UZ 0.9052
402 9R5 0.9051
403 F2W 0.9048
404 14W 0.9048
405 B2T 0.9048
406 JCZ 0.9048
407 BZ3 0.9045
408 6DP 0.9043
409 4CS 0.9043
410 S7A 0.9042
411 GGL 0.9042
412 5DL 0.9040
413 56D 0.9040
414 MAJ 0.9039
415 0A9 0.9039
416 HG3 0.9039
417 SQ4 0.9037
418 EV0 0.9037
419 0N7 0.9036
420 ANN 0.9036
421 PKU 0.9036
422 HF2 0.9035
423 AJY 0.9034
424 ENO 0.9034
425 BNF 0.9033
426 SHA 0.9033
427 TU0 0.9032
428 TYE 0.9031
429 K2T 0.9030
430 ET2 0.9029
431 HSX 0.9028
432 EVF 0.9028
433 HQD 0.9028
434 4YO 0.9028
435 HBO 0.9027
436 AMQ 0.9026
437 3MB 0.9024
438 4FF 0.9024
439 SYV 0.9024
440 LQ2 0.9022
441 I3E 0.9020
442 HDL 0.9020
443 NDG 0.9020
444 AOS 0.9018
445 TAG 0.9016
446 GNM 0.9016
447 FIX 0.9016
448 6MW 0.9015
449 36M 0.9012
450 SOV 0.9012
451 LPK 0.9012
452 DEW 0.9011
453 CXF 0.9011
454 A5H 0.9010
455 53C 0.9010
456 TWO 0.9009
457 4NB 0.9009
458 PD2 0.9009
459 3AL 0.9009
460 M3P 0.9008
461 717 0.9008
462 4AV 0.9007
463 9ON 0.9006
464 DMD 0.9006
465 MNP 0.9006
466 7R4 0.9005
467 VGD 0.9004
468 SSB 0.9003
469 DAH 0.9003
470 PNZ 0.9003
471 3ID 0.9002
472 AJV 0.9002
473 BEA 0.9001
474 CLW 0.9001
475 6HO 0.9001
476 F69 0.9000
477 STT 0.8999
478 N8Y 0.8999
479 RAT 0.8998
480 5LA 0.8998
481 264 0.8998
482 SZ7 0.8998
483 FDR 0.8996
484 692 0.8995
485 BRT 0.8994
486 36R 0.8994
487 DPN 0.8993
488 49F 0.8993
489 ORO 0.8993
490 2D2 0.8992
491 AL0 0.8990
492 OTR 0.8990
493 ODK 0.8989
494 EGR 0.8988
495 1AL 0.8987
496 SDD 0.8987
497 E5X 0.8987
498 4HM 0.8987
499 E4P 0.8985
500 TB8 0.8985
501 D1X 0.8985
502 A7W 0.8984
503 GJP 0.8983
504 DZA 0.8983
505 258 0.8982
506 5GT 0.8980
507 5RO 0.8980
508 1HN 0.8979
509 SMN 0.8979
510 2QC 0.8978
511 LDP 0.8978
512 505 0.8976
513 PBN 0.8976
514 BZJ 0.8974
515 5TY 0.8974
516 HHH 0.8973
517 8HC 0.8972
518 F4K 0.8972
519 FTV 0.8972
520 DRG 0.8971
521 REL 0.8970
522 MQN 0.8970
523 HL4 0.8970
524 ICO 0.8970
525 8GC 0.8968
526 URC 0.8968
527 5E5 0.8967
528 PHB 0.8966
529 55D 0.8965
530 QY9 0.8965
531 AS3 0.8964
532 4NM 0.8964
533 N91 0.8961
534 2HQ 0.8960
535 TYR 0.8959
536 0FK 0.8957
537 39O 0.8957
538 7UC 0.8956
539 TGX 0.8956
540 4RU 0.8955
541 3VX 0.8953
542 GCO 0.8953
543 FGZ 0.8953
544 EKZ 0.8952
545 BGU 0.8951
546 FZM 0.8950
547 6FB 0.8949
548 ABF 0.8949
549 8W9 0.8948
550 3R4 0.8948
551 F12 0.8947
552 H7Y 0.8947
553 FER 0.8946
554 SRO 0.8946
555 OOG 0.8945
556 4FA 0.8945
557 DHS 0.8943
558 ZXD 0.8941
559 M6Z 0.8941
560 51R 0.8941
561 UN1 0.8940
562 FBW 0.8938
563 W29 0.8937
564 GLO 0.8936
565 2FT 0.8936
566 4BZ 0.8936
567 SOR 0.8935
568 C0H 0.8933
569 SEP 0.8933
570 V1T 0.8932
571 DI6 0.8932
572 3VQ 0.8931
573 PAB 0.8931
574 LFQ 0.8930
575 D1G 0.8930
576 X6W 0.8930
577 NPO 0.8930
578 JR2 0.8928
579 PPT 0.8928
580 TSS 0.8928
581 OKG 0.8927
582 AMR 0.8927
583 5HN 0.8926
584 N2M 0.8925
585 MRW 0.8925
586 XAZ 0.8925
587 IFP 0.8925
588 HPP 0.8924
589 OVP 0.8924
590 YPN 0.8924
591 3PG 0.8924
592 DXP 0.8923
593 0TU 0.8923
594 1BN 0.8923
595 SNO 0.8922
596 AMH 0.8922
597 RNO 0.8922
598 MEQ 0.8921
599 OK7 0.8921
600 7MW 0.8921
601 P81 0.8921
602 PDC 0.8921
603 33S 0.8920
604 DQU 0.8920
605 NAG 0.8920
606 DOR 0.8920
607 49O 0.8920
608 PQK 0.8918
609 XRS 0.8917
610 S60 0.8917
611 URS 0.8916
612 C9E 0.8916
613 DAL DAL 0.8915
614 3HG 0.8914
615 KDV 0.8914
616 28A 0.8912
617 GWM 0.8911
618 B85 0.8911
619 UFV 0.8911
620 8G0 0.8911
621 LSQ 0.8909
622 A13 0.8909
623 4JT 0.8908
624 MPK 0.8908
625 ONH 0.8907
626 1Y6 0.8906
627 2BX 0.8906
628 NDH 0.8905
629 LFC 0.8904
630 6XI 0.8904
631 DC5 0.8903
632 ALA ALA 0.8902
633 FCD 0.8902
634 E3X 0.8902
635 LYS 0.8902
636 LVD 0.8900
637 1QP 0.8899
638 AZ9 0.8899
639 4AA 0.8899
640 Q06 0.8898
641 M2K 0.8898
642 ODO 0.8898
643 5XB 0.8897
644 SYC 0.8896
645 COU 0.8896
646 MMJ 0.8895
647 H42 0.8895
648 OXC 0.8895
649 TIU 0.8894
650 K7M 0.8893
651 PBZ 0.8893
652 BIK 0.8892
653 HBD 0.8892
654 FQX 0.8891
655 5JQ 0.8891
656 259 0.8889
657 SKF 0.8888
658 GUA 0.8888
659 PJL 0.8887
660 03V 0.8886
661 ES5 0.8886
662 FA1 0.8885
663 PBA 0.8884
664 5RN 0.8884
665 EA1 0.8884
666 SQ7 0.8883
667 QIV 0.8882
668 Y3L 0.8882
669 6ME 0.8880
670 4MA 0.8880
671 42J 0.8879
672 RSO 0.8879
673 4XS 0.8877
674 AEH 0.8876
675 JB5 0.8876
676 27B 0.8876
677 BQ5 0.8875
678 QWN 0.8873
679 34D 0.8868
680 EUG 0.8867
681 AUV 0.8866
682 A5P 0.8866
683 44V 0.8866
684 RNS 0.8865
685 4VY 0.8865
686 DA4 0.8865
687 3HA 0.8865
688 OCH 0.8864
689 AW5 0.8863
690 DOB 0.8863
691 BDP 0.8863
692 BEZ 0.8863
693 PFF 0.8862
694 KUF 0.8860
695 4XV 0.8860
696 7QS 0.8860
697 1KP 0.8859
698 AX7 0.8858
699 2FX 0.8858
700 WUB 0.8858
701 BHA 0.8858
702 7Q1 0.8857
703 DTY 0.8856
704 AA 0.8856
705 80G 0.8855
706 FA0 0.8855
707 X1R 0.8854
708 7I2 0.8854
709 4TU 0.8854
710 3VW 0.8854
711 QXW 0.8853
712 49P 0.8853
713 4HB 0.8851
714 0XT 0.8850
715 PEA 0.8850
716 GTQ 0.8850
717 BPU 0.8849
718 DBH 0.8849
719 2AQ 0.8848
720 28N 0.8848
721 9AP 0.8848
722 B62 0.8847
723 APG 0.8846
724 FAN 0.8845
725 JTH 0.8845
726 ANF 0.8844
727 DHM 0.8844
728 8TX 0.8844
729 5VM 0.8843
730 ABV 0.8842
731 JZA 0.8842
732 BRH 0.8840
733 RJY 0.8839
734 MAH 0.8838
735 4M0 0.8838
736 TOH 0.8837
737 OTW 0.8837
738 3J8 0.8836
739 8GL 0.8836
740 Q4G 0.8835
741 RP3 0.8835
742 RD4 0.8835
743 N0Z 0.8835
744 OW7 0.8835
745 F9Y 0.8835
746 RNT 0.8834
747 4FS 0.8833
748 LYL 0.8833
749 NIR 0.8832
750 GV9 0.8831
751 EMZ 0.8831
752 IQQ 0.8831
753 SME 0.8830
754 0FR 0.8828
755 3Y7 0.8828
756 XQ0 0.8827
757 IOP 0.8827
758 ITE 0.8827
759 152 0.8826
760 S0E 0.8826
761 DDU 0.8826
762 LTL 0.8826
763 AC6 0.8826
764 68A 0.8825
765 APS 0.8825
766 5JL 0.8822
767 86J 0.8820
768 L5D 0.8819
769 M5E 0.8818
770 Q02 0.8818
771 2FY 0.8817
772 MR1 0.8817
773 KT7 0.8816
774 YOF 0.8815
775 DHR 0.8811
776 MLT 0.8811
777 LDR 0.8810
778 V55 0.8810
779 XCZ 0.8810
780 DE3 0.8810
781 P72 0.8809
782 KOJ 0.8809
783 B55 0.8808
784 TTL 0.8808
785 FBU 0.8808
786 CC5 0.8807
787 MD6 0.8806
788 9RW 0.8806
789 6SD 0.8805
790 IV2 0.8803
791 GLY GLY 0.8803
792 BEN 0.8801
793 OA1 0.8800
794 JAH 0.8800
795 3M0 0.8800
796 QMS 0.8798
797 75K 0.8797
798 2D3 0.8797
799 DPT 0.8797
800 FP1 0.8797
801 AMS 0.8797
802 CIT 0.8796
803 1GP 0.8795
804 IYR 0.8795
805 4HC 0.8795
806 E0O 0.8794
807 CN0 0.8794
808 XM0 0.8794
809 CKA 0.8793
810 9BF 0.8793
811 BY5 0.8793
812 PBC 0.8793
813 XI7 0.8792
814 YRL 0.8792
815 AEG 0.8791
816 LMR 0.8791
817 54X 0.8790
818 PSE 0.8789
819 Q03 0.8789
820 MVN 0.8788
821 MUA 0.8787
822 GHM 0.8787
823 SW7 0.8787
824 0W8 0.8785
825 G3P 0.8785
826 BZQ 0.8785
827 K3Q 0.8784
828 293 0.8784
829 LTN 0.8784
830 TSU 0.8784
831 XYL 0.8783
832 KYN 0.8783
833 GCU 0.8783
834 TRP 0.8782
835 TCR 0.8781
836 DTR 0.8780
837 SG2 0.8780
838 SN4 0.8780
839 THA 0.8780
840 2AK 0.8779
841 HRM 0.8779
842 DXK 0.8779
843 MMS 0.8778
844 HHA 0.8778
845 0SY 0.8777
846 44W 0.8776
847 5CU 0.8775
848 2JK 0.8774
849 209 0.8772
850 ORN 0.8770
851 5RP 0.8770
852 3FH 0.8768
853 MS9 0.8767
854 G3H 0.8766
855 I3A 0.8766
856 826 0.8762
857 6OT 0.8762
858 RMN 0.8761
859 3F0 0.8761
860 SD4 0.8759
861 GRO 0.8759
862 GOE 0.8758
863 4BF 0.8758
864 HJ7 0.8757
865 FBF 0.8757
866 Q04 0.8757
867 BGC 0.8756
868 YIE 0.8755
869 JWS 0.8754
870 MJ2 0.8754
871 SYM 0.8753
872 ZYQ 0.8753
873 UFO 0.8752
874 OQC 0.8751
875 MZM 0.8751
876 PH2 0.8751
877 BTY 0.8750
878 5M0 0.8750
879 5QX 0.8748
880 VBC 0.8747
881 JSX 0.8746
882 TIA 0.8745
883 4A5 0.8745
884 S7J 0.8744
885 PMF 0.8742
886 3AE 0.8741
887 K5W 0.8741
888 SYA 0.8740
889 F0J 0.8740
890 XHP 0.8740
891 G12 0.8740
892 7MX 0.8739
893 CSN 0.8738
894 JMG 0.8737
895 MXN 0.8736
896 S1D 0.8734
897 0FO 0.8733
898 549 0.8733
899 PGH 0.8733
900 KMY 0.8733
901 4Z4 0.8732
902 HQ9 0.8732
903 NLQ 0.8729
904 2B4 0.8729
905 5RG 0.8729
906 I2E 0.8728
907 THU 0.8727
908 FQI 0.8727
909 PHI 0.8726
910 1KN 0.8724
911 0P6 0.8724
912 HHR 0.8722
913 NCA 0.8722
914 OAA 0.8722
915 DNC 0.8721
916 TJM 0.8721
917 BVA 0.8720
918 2MI 0.8720
919 NLE 0.8719
920 13P 0.8718
921 Z82 0.8718
922 M6N 0.8717
923 LAO 0.8717
924 B1J 0.8716
925 FWD 0.8714
926 HJ8 0.8714
927 K48 0.8713
928 E7Z 0.8712
929 FBS 0.8711
930 NPA 0.8711
931 4J8 0.8710
932 RM1 0.8708
933 5NU 0.8708
934 261 0.8707
935 NVU 0.8707
936 3OM 0.8706
937 MQB 0.8705
938 P4L 0.8704
939 7VS 0.8704
940 5B2 0.8703
941 3CR 0.8703
942 DK1 0.8702
943 SWX 0.8702
944 WOE 0.8702
945 23J 0.8701
946 BPN 0.8700
947 9RH 0.8700
948 HNE 0.8700
949 5OO 0.8700
950 GLC 0.8700
951 54G 0.8700
952 AZM 0.8699
953 CWS 0.8699
954 Q24 0.8699
955 GP9 0.8698
956 R9S 0.8698
957 MOK 0.8698
958 ZRK 0.8696
959 BSA 0.8696
960 XFE 0.8696
961 JF1 0.8695
962 3Z8 0.8695
963 ZEC 0.8694
964 MNN 0.8694
965 4HP 0.8694
966 H5B 0.8692
967 ERZ 0.8692
968 ROI 0.8692
969 BAM 0.8691
970 Q71 0.8690
971 XRG 0.8688
972 ADA 0.8688
973 M78 0.8686
974 6R8 0.8686
975 GTR 0.8685
976 AAN 0.8683
977 DX3 0.8683
978 XXG 0.8682
979 H70 0.8681
980 535 0.8679
981 XRX 0.8679
982 P84 0.8678
983 AEF 0.8678
984 2PG 0.8677
985 6PC 0.8677
986 RCV 0.8674
987 M0Q 0.8674
988 B2J 0.8671
989 PRL 0.8670
990 CLU 0.8670
991 IQ5 0.8670
992 CWM 0.8670
993 APZ 0.8670
994 OCZ 0.8669
995 2GD 0.8669
996 SAN 0.8669
997 AVJ 0.8669
998 FCR 0.8668
999 2GQ 0.8668
1000 PLP 0.8667
1001 PQ0 0.8667
1002 CLZ 0.8666
1003 CTL 0.8665
1004 QIC 0.8665
1005 LZ5 0.8665
1006 UNU 0.8664
1007 DNA 0.8663
1008 M1H 0.8663
1009 S0D 0.8663
1010 AG2 0.8662
1011 EQW 0.8662
1012 8CM 0.8661
1013 270 0.8661
1014 I4B 0.8661
1015 CWD 0.8661
1016 AQO 0.8660
1017 4G2 0.8660
1018 2K8 0.8660
1019 1DJ 0.8660
1020 NIO 0.8660
1021 2KU 0.8659
1022 0VT 0.8659
1023 FE DB1 0.8659
1024 NGO 0.8658
1025 Q88 0.8658
1026 NIY 0.8658
1027 LR5 0.8657
1028 3VS 0.8657
1029 RP5 0.8657
1030 P9E 0.8656
1031 SR1 0.8655
1032 6C8 0.8654
1033 1P7 0.8654
1034 SQV 0.8653
1035 CNI 0.8653
1036 6VD 0.8653
1037 DEE 0.8652
1038 7WG 0.8651
1039 0K7 0.8651
1040 HHS 0.8651
1041 ASO 0.8650
1042 174 0.8649
1043 M4S 0.8648
1044 OEG 0.8647
1045 NOJ 0.8647
1046 CCU 0.8647
1047 CTV 0.8642
1048 NLA 0.8641
1049 GYE 0.8640
1050 RVE 0.8640
1051 FOT 0.8640
1052 KBB 0.8640
1053 II4 0.8639
1054 SX1 0.8639
1055 FLC 0.8638
1056 091 0.8637
1057 ES0 0.8635
1058 DYA 0.8635
1059 OKM 0.8635
1060 M5K 0.8633
1061 6ZX 0.8632
1062 KKN 0.8630
1063 GBN 0.8627
1064 GNV 0.8627
1065 ICT 0.8627
1066 PEP 0.8627
1067 AJ2 0.8624
1068 12Q 0.8624
1069 0OC 0.8624
1070 5MK 0.8622
1071 BL0 0.8621
1072 8D6 0.8619
1073 7N0 0.8615
1074 0GZ 0.8615
1075 4FP 0.8614
1076 COI 0.8613
1077 AZ8 0.8612
1078 2LT 0.8612
1079 2UB 0.8608
1080 JBK 0.8607
1081 4FE 0.8606
1082 XBT 0.8606
1083 6L6 0.8605
1084 JF2 0.8604
1085 2CZ 0.8603
1086 P92 0.8602
1087 DUR 0.8602
1088 MWP 0.8602
1089 4KL 0.8600
1090 TTY 0.8596
1091 TOF 0.8591
1092 4JC 0.8591
1093 5WV 0.8590
1094 A1Y 0.8584
1095 NBG 0.8579
1096 S3C 0.8578
1097 BWD 0.8569
1098 DRL 0.8564
1099 4NZ 0.8561
1100 THM 0.8561
1101 ARG 0.8557
1102 XXP 0.8555
1103 3SL 0.8549
1104 6CS 0.8547
1105 9SE 0.8545
1106 15L 0.8544
1107 ZZZ 0.8538
1108 AAS 0.8537
1109 BTM 0.8534
1110 Q6T 0.8527
1111 OTD 0.8527
1112 ACA 0.8522
1113 JYB 0.8512
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 7A16; Ligand: HZE; Similar sites found with APoc: 2
This union binding pocket(no: 1) in the query (biounit: 7a16.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 3L24 GOA 2.42588
2 3L24 GOA 2.42588
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