Receptor
PDB id Resolution Class Description Source Keywords
2ZX3 2.1 Å NON-ENZYME: OTHER RHAMNOSE-BINDING LECTIN CSL3 ONCORHYNCHUS KETA LECTIN RHAMNOSE INNATE IMMUNITY IMMUNE SYSTEM SUGAR BINDING PROTEIN
Ref.: STRUCTURE OF RHAMNOSE-BINDING LECTIN CSL3: UNIQUE PSEUDO-TETRAMERIC ARCHITECTURE OF A PATTERN RECOGNITION PROTEIN J.MOL.BIOL. V. 391 390 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BGC GLA A:196;
A:198;
B:198;
B:200;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
342.297 n/a O1C(O...
PO4 B:196;
B:197;
Invalid;
Invalid;
none;
none;
submit data
94.971 O4 P [O-]P...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2ZX2 1.8 Å NON-ENZYME: OTHER RHAMNOSE-BINDING LECTIN CSL3 ONCORHYNCHUS KETA LECTIN RHAMNOSE INNATE IMMUNITY IMMUNE SYSTEM SUGAR BINDING PROTEIN
Ref.: STRUCTURE OF RHAMNOSE-BINDING LECTIN CSL3: UNIQUE PSEUDO-TETRAMERIC ARCHITECTURE OF A PATTERN RECOGNITION PROTEIN J.MOL.BIOL. V. 391 390 2009
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 2ZX3 - BGC GLA n/a n/a
2 2ZX2 - RAM C6 H12 O5 C[C@H]1[C@....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 2ZX3 - BGC GLA n/a n/a
2 2ZX2 - RAM C6 H12 O5 C[C@H]1[C@....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 2ZX3 - BGC GLA n/a n/a
2 2ZX2 - RAM C6 H12 O5 C[C@H]1[C@....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: BGC GLA; Similar ligands found: 183
No: Ligand ECFP6 Tc MDL keys Tc
1 MLB 1 1
2 BMA GLA 1 1
3 GLA GLC 1 1
4 GLA BMA 1 1
5 MAN BMA 1 1
6 BGC GLA 1 1
7 GAL GAL 1 1
8 LAK 1 1
9 GLA BGC 1 1
10 GLC GLC GLC GLC BGC 0.953488 1
11 GLC GLC GLC GLC GLC BGC 0.953488 1
12 MAN MAN MAN 0.953488 1
13 GLC GLC GLC 0.953488 1
14 AHR AHR 0.75 0.857143
15 FUB AHR 0.75 0.857143
16 MAN MAN BMA MAN 0.732143 1
17 MAN MAN MAN MAN 0.732143 1
18 FUB AHR AHR 0.702128 0.857143
19 AHR AHR AHR 0.702128 0.857143
20 GLC GLC GLC GLC GLC GLC 0.684211 1
21 GLC GLC GLC GLC 0.678571 1
22 MAN MMA 0.66 0.942857
23 GLC GLC GLC BGC 0.633333 1
24 M5S 0.606557 1
25 MAN BMA MAN MAN MAN 0.606557 1
26 MAN MAN MAN BMA MAN 0.575758 1
27 BMA BMA GLA BMA BMA 0.546875 1
28 MAN MMA MAN 0.540984 0.942857
29 FRU GLC GLA 0.515625 0.891892
30 RAF 0.515625 0.891892
31 MAN 0.511628 0.848485
32 WOO 0.511628 0.848485
33 GAL 0.511628 0.848485
34 BMA 0.511628 0.848485
35 GLC 0.511628 0.848485
36 ALL 0.511628 0.848485
37 GLA 0.511628 0.848485
38 GXL 0.511628 0.848485
39 GIV 0.511628 0.848485
40 BGC 0.511628 0.848485
41 MAN MAN MAN BMA MAN MAN MAN 0.5 0.942857
42 MAN H1M MAN 0.492537 0.868421
43 BMA BMA MAN 0.491228 0.970588
44 NGB 0.485294 0.622642
45 4CQ 0.483871 0.970588
46 WZ2 0.477612 0.868421
47 GAL GLC 0.472727 1
48 LAT 0.472727 1
49 BGC GLC 0.472727 1
50 MAL 0.472727 1
51 LBT 0.472727 1
52 CBI 0.472727 1
53 GLA GLA 0.472727 1
54 B2G 0.472727 1
55 BGC GAL 0.472727 1
56 BMA GAL 0.472727 1
57 GLC BGC 0.472727 1
58 GLA GAL 0.472727 1
59 N9S 0.472727 1
60 BMA BMA 0.472727 1
61 MAL MAL 0.472727 0.970588
62 BGC BMA 0.472727 1
63 GAL BGC 0.472727 1
64 GLC GAL 0.472727 1
65 CBK 0.472727 1
66 MAB 0.472727 1
67 NAG MAN BMA 0.472222 0.733333
68 NAG MAN MAN 0.472222 0.733333
69 RGG 0.471698 0.882353
70 SUC GLA 0.471429 0.891892
71 WZ3 0.463768 0.916667
72 DEG 0.462963 0.769231
73 BMA BMA BMA BMA BMA BMA MAN 0.459016 0.970588
74 MAN BMA BMA BMA BMA BMA 0.459016 0.970588
75 NOJ BGC 0.459016 0.727273
76 DMJ MAN 0.459016 0.727273
77 IFM MAN 0.451613 0.744186
78 G6P 0.45098 0.674419
79 BG6 0.45098 0.674419
80 A6P 0.45098 0.674419
81 M6P 0.45098 0.674419
82 BGP 0.45098 0.674419
83 M6D 0.45098 0.674419
84 EBQ 0.446429 0.837838
85 MAN GLC 0.446429 1
86 M3M 0.446429 1
87 EBG 0.446429 0.837838
88 LB2 0.446429 1
89 CTR 0.440678 1
90 B4G 0.440678 1
91 GLC GAL GAL 0.440678 1
92 CT3 0.440678 1
93 MAN MAN BMA BMA BMA BMA 0.440678 1
94 GLC GLC GLC GLC GLC 0.440678 1
95 GLC GLC GLC GLC GLC GLC GLC GLC 0.440678 1
96 GLC GLC BGC GLC GLC GLC GLC 0.440678 1
97 BGC GLC GLC GLC GLC 0.440678 1
98 MT7 0.440678 1
99 MAN BMA BMA BMA BMA 0.440678 1
100 GLC BGC BGC 0.440678 1
101 CEY 0.440678 1
102 BMA BMA BMA 0.440678 1
103 BMA BMA BMA BMA BMA 0.440678 1
104 CTT 0.440678 1
105 DXI 0.440678 1
106 MLR 0.440678 1
107 GLC BGC GLC 0.440678 1
108 GLC BGC BGC BGC BGC BGC 0.440678 1
109 CEX 0.440678 1
110 BGC GLC GLC 0.440678 1
111 GLC GLC GLC GLC GLC GLC GLC 0.440678 1
112 GLC BGC BGC BGC BGC 0.440678 1
113 MTT 0.440678 1
114 CE6 0.440678 1
115 BGC GLC GLC GLC GLC GLC GLC 0.440678 1
116 BMA MAN BMA 0.440678 1
117 BGC BGC BGC BGC BGC BGC 0.440678 1
118 CE5 0.440678 1
119 MAN BMA BMA 0.440678 1
120 GAL GAL GAL 0.440678 1
121 BMA BMA BMA BMA BMA BMA 0.440678 1
122 GLA GAL GLC 0.440678 1
123 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.440678 1
124 GLC GLC BGC 0.440678 1
125 BGC BGC BGC GLC 0.440678 1
126 BGC GLC GLC GLC 0.440678 1
127 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.440678 1
128 CE8 0.440678 1
129 1GN ACY GAL ACY 1GN BGC GAL BGC 0.439024 0.6875
130 ACY 1GN GAL 1GN BGC ACY GAL BGC 0.439024 0.6875
131 JZR 0.438596 0.714286
132 GLC HEX 0.438596 0.714286
133 BHG 0.438596 0.714286
134 HEX GLC 0.438596 0.714286
135 TRE 0.4375 1
136 NAG BMA MAN MAN MAN MAN 0.4375 0.733333
137 KGM 0.431034 0.738095
138 B7G 0.431034 0.738095
139 GAL GAL SO4 0.430769 0.702128
140 GLC BGC BGC BGC XYS BGC XYS XYS 0.43038 0.916667
141 MBG 0.428571 0.857143
142 MMA 0.428571 0.857143
143 GYP 0.428571 0.857143
144 2M4 0.428571 1
145 BGC BGC 0.428571 1
146 MAN MAN 0.428571 1
147 AMG 0.428571 0.857143
148 HSJ 0.423729 0.738095
149 BNG 0.423729 0.738095
150 BOG 0.423729 0.738095
151 SER MAN 0.423729 0.775
152 G1P 0.423077 0.697674
153 GL1 0.423077 0.697674
154 M1P 0.423077 0.697674
155 XGP 0.423077 0.697674
156 BGC BGC XYS BGC 0.418919 0.942857
157 GAL FUC 0.416667 0.941176
158 6SA 0.414894 0.733333
159 GAL BGC NAG GAL 0.413333 0.733333
160 GAL BGC BGC XYS 0.410959 0.942857
161 BGC BGC BGC ASO BGC BGC ASO 0.409836 1
162 BGC BGC BGC 0.409836 1
163 GLC BGC BGC BGC BGC BGC BGC 0.409836 1
164 BGC BGC BGC GLC BGC BGC 0.409836 1
165 BGC BGC BGC BGC BGC 0.409836 1
166 GLA EGA 0.409836 0.942857
167 GLC BGC BGC BGC 0.409836 1
168 DGD 0.409639 0.733333
169 BMA NAG MAN MAN MAN MAN MAN MAN MAN 0.409091 0.733333
170 GLC GLC BGC XYS BGC XYS 0.407895 0.942857
171 MAN MAN NAG MAN NAG 0.406977 0.6875
172 NAG NAG BMA MAN MAN 0.406977 0.6875
173 T6P 0.40678 0.767442
174 EDG AHR 0.40678 0.617021
175 BMA MAN MAN 0.40625 1
176 GLA GAL BGC 0.40625 1
177 GLA GAL GAL 0.40625 1
178 IAB 0.404494 0.733333
179 MAN MAN BMA 0.403226 1
180 BGC BGC XYS BGC XYS BGC XYS 0.402597 0.942857
181 GLC BGC BGC XYS BGC XYS XYS 0.402597 0.942857
182 BGC BGC BGC XYS BGC XYS XYS 0.402597 0.942857
183 GLC GLC XYS XYS 0.4 0.914286
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2ZX2; Ligand: RAM; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2zx2.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2ZX2; Ligand: RAM; Similar sites found: 100
This union binding pocket(no: 2) in the query (biounit: 2zx2.bio1) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1IXE COA 0.009883 0.42588 None
2 1ZUI SKM 0.03861 0.41451 None
3 2PYY GLU 0.0139 0.40664 None
4 1F2U ATP 0.03144 0.40654 None
5 3QKT ANP 0.03347 0.40418 None
6 1YZG GDP 0.02037 0.40211 None
7 4BUZ OCZ 0.04883 0.40187 None
8 4BUZ OAD 0.04883 0.40187 None
9 4BUZ NAD 0.04244 0.40187 None
10 1ZJ6 G3D 0.0208 0.40152 None
11 1R4A GNP 0.03964 0.40136 None
12 1RRC ADP 0.01008 0.40574 1.02564
13 2EW5 Y12 0.003443 0.4524 1.10497
14 1MR3 G3D 0.005463 0.43221 1.10497
15 2JG1 ANP 0.01467 0.4178 1.53846
16 3A4M ADP 0.01277 0.40656 1.53846
17 1U7Z PMT 0.04772 0.40039 1.53846
18 4S3R 7SA 0.006825 0.45503 2.05128
19 5KUT GDP 0.006546 0.42813 2.1164
20 2CXG GLC GLC 0.004752 0.42439 2.5641
21 1A59 COA 0.0176 0.41284 2.5641
22 2FAV APR 0.03359 0.40219 2.77778
23 4NBI D3Y 0.02715 0.40811 3.04878
24 2NYR SVR 0.03814 0.44235 3.07692
25 1WVC CTP 0.01171 0.43272 3.07692
26 1N0U SO1 0.01418 0.41586 3.07692
27 2ZE7 AMP 0.02239 0.41288 3.07692
28 4C4A SAH 0.03058 0.40356 3.07692
29 2ZE7 DST 0.04682 0.40044 3.07692
30 1CT9 GLN 0.0182 0.40007 3.07692
31 4OI4 ATP 0.02272 0.40667 3.47826
32 4JSR 1NQ 0.03601 0.42854 3.58974
33 2OFW ADX 0.03205 0.41972 3.58974
34 1CSI OAA 0.04294 0.4152 3.58974
35 4QM7 GTP 0.01444 0.40668 4.09357
36 4B0T ADP 0.01652 0.42007 4.10256
37 1VB3 KPA 0.01043 0.4075 4.10256
38 4B74 1LH 0.03063 0.40232 4.10256
39 4YEF 4CQ 0.01688 0.42938 4.49438
40 3UIE ANP 0.004594 0.44005 4.61538
41 3G5S GSH 0.007228 0.41956 4.61538
42 1ME8 RVP 0.04581 0.40886 4.61538
43 5IXJ THR 0.02893 0.40814 4.61538
44 2IV2 2MD 0.04384 0.40534 4.61538
45 2PL3 ADP 0.01509 0.40373 4.61538
46 3QF7 ANP 0.02914 0.40089 4.61538
47 5F90 GLA GAL 0.005497 0.40448 5.12821
48 5F90 GLA GAL BGC 5VQ 0.005613 0.4042 5.12821
49 3ZFD ANP 0.0212 0.40391 5.12821
50 1UJ2 ADP 0.0402 0.40385 5.12821
51 1UJ2 C5P 0.04291 0.40209 5.12821
52 5F90 LMR 0.003897 0.40112 5.12821
53 3NBC LAT 0.01025 0.40173 5.40541
54 1OS1 ATP 0.003729 0.46251 5.64103
55 1OS1 PYR 0.003953 0.46251 5.64103
56 1M7G ADP 0.01554 0.42922 5.64103
57 1M7G ADX 0.01973 0.42582 5.64103
58 3JQ9 NAP 0.04346 0.40152 5.64103
59 2PEZ DAT 0.02186 0.42414 6.14525
60 3HRD MCN 0.03766 0.40387 6.15385
61 1S8G DAO 0.01563 0.40271 6.61157
62 4D86 ADP 0.01734 0.41662 6.66667
63 2CKM AA7 0.04492 0.41391 6.66667
64 1XKV ATP 0.01387 0.41299 6.66667
65 3H0L ADP 0.009188 0.41231 6.66667
66 2D2I NAP 0.02284 0.41123 6.66667
67 3PT9 SAH 0.01833 0.40791 6.66667
68 1KY3 GDP 0.022 0.40289 7.14286
69 1XMV ADP 0.007036 0.42726 7.17949
70 2VF7 ADP 0.01755 0.40661 7.17949
71 4J3L AJ5 0.03308 0.40091 7.17949
72 2ZR9 DTP 0.004411 0.43581 7.69231
73 4OB6 S2T 0.01305 0.41192 7.69231
74 1OE0 TTP 0.03596 0.40556 7.69231
75 3N9R TD3 0.01438 0.40134 7.69231
76 5EP2 AZU 0.001495 0.46971 7.8125
77 4N4J HG1 0.02711 0.41562 8.20513
78 3X0D SAH 0.03265 0.40206 8.20513
79 1VHT BA3 0.01955 0.403 8.71795
80 4JWH SAH 0.03855 0.40251 8.71795
81 2BFR ADP 0.02328 0.40895 9.375
82 1FZQ GDP 0.01954 0.40065 9.39227
83 3O0Q TTP 0.03663 0.4325 9.74359
84 3O0Q ADN 0.03746 0.4325 9.74359
85 2Z48 NGA 0.001813 0.42302 9.74359
86 2Z48 A2G 0.005114 0.41126 9.74359
87 3QV1 NAD 0.03078 0.40536 9.74359
88 4MKG AP5 0.04033 0.41635 10.2564
89 2FH5 GTP 0.02493 0.4075 10.2703
90 1W0J ADP 0.01181 0.41985 10.7692
91 2V7Q ATP 0.01264 0.41615 10.7692
92 1W0J ADP BEF 0.02736 0.40219 10.7692
93 2JLR ANP 0.02643 0.40027 10.7692
94 3ZIA ATP 0.007706 0.42581 11.2821
95 3ZIA ADP 0.01119 0.42147 11.2821
96 2QG6 NMN 0.01717 0.42167 12.8205
97 5MDH NAD 0.04188 0.40471 13.3333
98 4J5R A1R 0.02858 0.40735 17.1233
99 3FYH ADP 0.002703 0.46087 17.4359
100 2GDJ ANP 0.003947 0.43366 17.4359
Pocket No.: 3; Query (leader) PDB : 2ZX2; Ligand: RAM; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2zx2.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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