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Receptor
PDB id Resolution Class Description Source Keywords
2ZX2 1.8 Å NON-ENZYME: OTHER RHAMNOSE-BINDING LECTIN CSL3 ONCORHYNCHUS KETA LECTIN RHAMNOSE INNATE IMMUNITY IMMUNE SYSTEM SUGAR BINDPROTEIN
Ref.: STRUCTURE OF RHAMNOSE-BINDING LECTIN CSL3: UNIQUE PSEUDO-TETRAMERIC ARCHITECTURE OF A PATTERN RECOGNI PROTEIN J.MOL.BIOL. V. 391 390 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PO4 A:196;
A:197;
B:196;
B:197;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
94.971 O4 P [O-]P...
RAM A:198;
B:198;
B:199;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
164.156 C6 H12 O5 C[C@H...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2ZX2 1.8 Å NON-ENZYME: OTHER RHAMNOSE-BINDING LECTIN CSL3 ONCORHYNCHUS KETA LECTIN RHAMNOSE INNATE IMMUNITY IMMUNE SYSTEM SUGAR BINDPROTEIN
Ref.: STRUCTURE OF RHAMNOSE-BINDING LECTIN CSL3: UNIQUE PSEUDO-TETRAMERIC ARCHITECTURE OF A PATTERN RECOGNI PROTEIN J.MOL.BIOL. V. 391 390 2009
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 2ZX3 - BGC GLA n/a n/a
2 2ZX2 - RAM C6 H12 O5 C[C@H]1[C@....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 2ZX3 - BGC GLA n/a n/a
2 2ZX2 - RAM C6 H12 O5 C[C@H]1[C@....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 2ZX3 - BGC GLA n/a n/a
2 2ZX2 - RAM C6 H12 O5 C[C@H]1[C@....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: RAM; Similar ligands found: 9
No: Ligand ECFP6 Tc MDL keys Tc
1 FCB 1 1
2 FUC 1 1
3 FCA 1 1
4 XXR 1 1
5 G6D 1 1
6 RAM 1 1
7 RM4 1 1
8 FUL 1 1
9 FUF 0.424242 0.846154
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2ZX2; Ligand: RAM; Similar sites found with APoc: 319
This union binding pocket(no: 1) in the query (biounit: 2zx2.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 4RR7 A3S None
2 1IXE COA None
3 1YZG GDP None
4 1ZUI SKM None
5 1ZJ6 G3D None
6 1F2U ATP None
7 4BQS K2Q None
8 4BQS ADP None
9 1R4A GNP None
10 1UPT GTP None
11 3QKT ANP None
12 1AKY AP5 None
13 5O74 GDP None
14 4TTQ ATP None
15 3WB0 FEG None
16 2F9L GDP None
17 2PYY GLU None
18 4BFW ZVW None
19 1QPR PPC None
20 1S8F GDP None
21 4XTX 590 None
22 3BF1 ADP None
23 1O3Y GTP None
24 1Z0F GDP None
25 1LSS NAD None
26 2ZEJ GDP None
27 1XFF GLU 1.02564
28 1NJF AGS 1.02564
29 1RRC ADP 1.02564
30 4YMU ATP 1.02564
31 5NWD 9C8 1.04712
32 2EW5 Y12 1.10497
33 1MR3 G3D 1.10497
34 1G0H IPD 1.53846
35 2JG1 ANP 1.53846
36 3A4M ADP 1.53846
37 1U7Z PMT 1.53846
38 2C9O ADP 1.53846
39 5XKT GNP 1.53846
40 3E70 GDP 1.53846
41 3MD0 GDP 1.53846
42 2BME GNP 1.6129
43 1Z0K GTP 1.74419
44 3HU3 AGS 2.05128
45 4S3R 7SA 2.05128
46 5FJN BE2 2.05128
47 5J6D 6H5 2.05128
48 2A92 NAI 2.05128
49 5TSH ANP 2.05128
50 5TSH ADP 2.05128
51 3COB ADP 2.05128
52 5KUT GDP 2.1164
53 1DR1 NAP 2.1164
54 1DR1 HBI 2.1164
55 2QQ0 TMP 2.17391
56 2QQ0 ADP 2.17391
57 2QQ0 ANP 2.17391
58 2QQ0 THM 2.17391
59 5WYZ 7VF 2.5641
60 1A59 COA 2.5641
61 2CXG GLC GLC 2.5641
62 1T90 NAD 2.5641
63 4QOS ADP 2.5641
64 1F6B GDP 2.5641
65 3MAG SAH 2.5641
66 4IQY AR6 2.5641
67 2BNE U5P 2.5641
68 2I0K FAD 2.5641
69 5LD5 NAD 2.5641
70 5VBC SAH 2.5641
71 2NCD ADP 2.5641
72 5UR0 NAD 2.5641
73 5VAC SAH 2.5641
74 2BNF UTP 2.5641
75 5VA6 SAH 2.5641
76 4NBI D3Y 3.04878
77 6EQS BV8 3.07692
78 1WVC CTP 3.07692
79 4L1F FAD 3.07692
80 4IEE AGS 3.07692
81 1CT9 GLN 3.07692
82 1KOL NAD 3.07692
83 1TQ4 GDP 3.07692
84 5HCN GCP 3.07692
85 4NE2 ADP 3.07692
86 4NE2 SH2 3.07692
87 2ZE7 DST 3.07692
88 1ZIN AP5 3.07692
89 2ZE7 AMP 3.07692
90 4EN4 ATP 3.07692
91 4EN4 GT0 3.07692
92 4EN4 GT1 3.07692
93 4A22 TD4 3.07692
94 5MW8 ATP 3.07692
95 2H7C SIA 3.07692
96 1MJT ITU 3.07692
97 4D81 ADP 3.07692
98 4UTG ANP 3.07692
99 3DZD ADP 3.07692
100 4C4A SAH 3.07692
101 2C6Q IMP 3.07692
102 3ZS9 ADP ALF 3.07692
103 4UA3 COA 3.09278
104 3H86 AP5 3.125
105 5UQW GDP 3.1746
106 5FUW QBT 3.2967
107 4OI4 ATP 3.47826
108 2GJ8 ALF GDP 3.48837
109 2OFW ADX 3.58974
110 1AJ8 COA 3.58974
111 1CSI OAA 3.58974
112 1CSI CMX 3.58974
113 6F5W KG1 3.58974
114 4JSR 1NQ 3.58974
115 5BYK A3P 3.58974
116 5BYK OAQ 3.58974
117 2ABS ACP 3.58974
118 2ORV 4TA 3.58974
119 4XCZ T3Q 3.58974
120 4XCZ FON 3.58974
121 1W4R TTP 3.58974
122 5ZBR ANP 3.58974
123 6DA9 FMN 3.58974
124 3L4S 3PG 3.58974
125 4IXH IMP 3.58974
126 2D7D ADP 3.58974
127 3L4S NAD 3.58974
128 5L3V GDP 3.58974
129 2IXE ATP 3.58974
130 5LLB 6YZ 3.58974
131 3RFA SAM 3.58974
132 5LYH 7B8 3.62694
133 4QM7 GTP 4.09357
134 4B74 1LH 4.10256
135 1SVM ATP 4.10256
136 4B0T ADP 4.10256
137 1KQF MGD 4.10256
138 4TL6 ANP 4.10256
139 3QVV A3P 4.10256
140 4ONQ SFG 4.10256
141 1EXF GLY 4.10256
142 4POW OP1 4.10256
143 1OZH HE3 4.10256
144 6EL3 NAP 4.10256
145 4GIM PSU 4.10256
146 3BXF 13P 4.31373
147 1I1D 16G 4.34783
148 5Z2M GTP 4.54545
149 1KO8 6PG 4.57143
150 3UIE ANP 4.61538
151 2PL3 ADP 4.61538
152 5CPS GLC GLC GLC GLC GLC GLC GLC GLC 4.61538
153 5CPS GLC GLC GLC GLC GLC GLC GLC GLC GLC 4.61538
154 3G5S GSH 4.61538
155 3NRR D16 4.61538
156 3NRR NAP 4.61538
157 6CQW HI6 4.61538
158 6AM8 PLT 4.61538
159 1HDG NAD 4.61538
160 5EHZ 5NZ 4.61538
161 6G14 G4P 4.61538
162 3QF7 ANP 4.61538
163 1RJ9 GCP 4.61538
164 5BW4 SAM 4.61538
165 6AMI TRP 4.61538
166 4B5W PYR 4.61538
167 6CUZ FEV 4.61538
168 2BJK NAD 4.61538
169 3FSY SCA 4.61538
170 3G5N PB2 5.12821
171 5AHM IMP 5.12821
172 5Z69 AGS 5.12821
173 1PHP ADP 5.12821
174 3PFD FDA 5.12821
175 3G5D 1N1 5.12821
176 3BOS CDP 5.12821
177 1VA6 P2S 5.12821
178 1VA6 ADP 5.12821
179 1UM0 FMN 5.12821
180 1UJ2 ADP 5.12821
181 1UJ2 C5P 5.12821
182 3ZFD ANP 5.12821
183 5F90 LMR 5.12821
184 3ZQ6 ADP ALF 5.12821
185 1RC0 KT5 5.12821
186 5F90 GLA GAL BGC 5VQ 5.12821
187 5F90 GLA GAL 5.12821
188 2VBU CDP 5.14706
189 4V0K GDP 5.32544
190 4XF6 LIP 5.49451
191 4XF6 INS 5.49451
192 4XF6 ADP 5.49451
193 4MKF AP5 5.52995
194 1OS1 PYR 5.64103
195 1OS1 ATP 5.64103
196 2VB6 ADP BEF 5.64103
197 1X6V ADP 5.64103
198 1M7G ADP 5.64103
199 4Z87 5GP 5.64103
200 1M7G ADX 5.64103
201 4TVD BGC 5.64103
202 1XHC FAD 5.64103
203 2HF9 GSP 5.64103
204 1PN4 HDC 5.64103
205 5EYG NAP 5.64103
206 2B4R NAD 5.64103
207 2B4R AES 5.64103
208 5EXT ADP 5.76923
209 2PEZ GGZ 6.14525
210 2PEZ DAT 6.14525
211 2V3V MGD 6.15385
212 1S5P LYS GLY GLY ALA ALY ARG HIS ARG 6.15385
213 3DC4 ADP 6.15385
214 4JWF SAH 6.15385
215 1T36 ADP 6.15385
216 1RPN GDP 6.15385
217 2CJF RP4 6.36943
218 2HV8 GTP 6.39535
219 5WS9 AMP 6.66667
220 1XKV ATP 6.66667
221 4D86 ADP 6.66667
222 2D2I NAP 6.66667
223 2CKM AA7 6.66667
224 2P8U COA 6.66667
225 3B20 NAD 6.66667
226 3PT9 SAH 6.66667
227 3H0L ADP 6.66667
228 1KY3 GDP 7.14286
229 1XMV ADP 7.17949
230 5X9D 80F 7.17949
231 4BUY F37 7.17949
232 2J4K U5P 7.17949
233 2Q2Y MKR 7.17949
234 2Q2Y ADP 7.17949
235 4J3L AJ5 7.17949
236 1DL5 SAH 7.17949
237 3T7V SAM 7.17949
238 2NXE SAM 7.17949
239 1QPG MAP 7.17949
240 3WXM GTP 7.17949
241 4PX9 ADP 7.53425
242 2ZR9 DTP 7.69231
243 1OE0 TTP 7.69231
244 3C56 PH4 7.69231
245 1XP8 AGS 7.69231
246 3N9R TD3 7.69231
247 4KYQ FLC 7.69231
248 5EP2 AZU 7.8125
249 4V15 PLP 8.20513
250 5Y6N ADP 8.20513
251 3X0D SAH 8.20513
252 3WLE NAD 8.20513
253 4N4J HG1 8.20513
254 2XAU ADP 8.20513
255 4FRZ ADP 8.20513
256 1Z6T ADP 8.20513
257 3G6K FAD 8.71795
258 3G6K POP 8.71795
259 1VHT BA3 8.71795
260 4JWH SAH 8.71795
261 3EWP APR 9.03955
262 4C3Y ANB 9.23077
263 5C9P FUC 9.23077
264 1BW9 NAD 9.23077
265 1FZQ GDP 9.39227
266 3O0Q ADN 9.74359
267 3O0Q GDP 9.74359
268 3O0Q TTP 9.74359
269 3QV1 NAD 9.74359
270 2Z49 AMG 9.74359
271 4LC1 GDP 9.74359
272 1FNN ADP 9.74359
273 5XNC MTA 9.74359
274 4HAT GNP 9.74359
275 6CIT GNP 9.74359
276 5UWH GNP 9.74359
277 5UWO GNP 9.74359
278 5UWW GNP 9.74359
279 5UWR GNP 9.74359
280 5UWI GNP 9.74359
281 5DIF GNP 9.74359
282 1YTM ATP 10.2564
283 4GYS MLI 10.2564
284 4MKG AP5 10.2564
285 1SVK ALF GDP 10.2564
286 2FH5 GTP 10.2703
287 1W0J ADP 10.7692
288 2CK3 ANP 10.7692
289 2V7Q ATP 10.7692
290 2JLR ANP 10.7692
291 1W0J ADP BEF 10.7692
292 2CK3 ADP 10.7692
293 3TCT 3MI 11.0236
294 3ZIA ATP 11.2821
295 3ZIA ADP 11.2821
296 5L3S GNP 11.2821
297 2J0W ASP 11.2821
298 4RRG A3T 11.3475
299 3PD2 A3S 11.5646
300 2QG6 NMN 12.8205
301 1RM4 NDP 12.8205
302 3KTA AP5 13.1868
303 5UGH 8AJ 13.3333
304 1XEX ATP 13.7363
305 1TT8 PHB 14.0244
306 1OFU GDP 14.2857
307 2WYA HMG 14.8718
308 4ZNL BEF ADP 15.3846
309 3B1J NAD 16
310 4J5R A1R 17.1233
311 3FYH ADP 17.4359
312 2GDJ ANP 17.4359
313 4HI0 GDP 17.4359
314 1LBZ FBP 17.4359
315 2ANM CDO 17.9487
316 5ZB0 ADP 20
317 5ZB0 TYD 20
318 2CE7 ADP 22.0513
319 4GLL NAD 26.1538
Pocket No.: 2; Query (leader) PDB : 2ZX2; Ligand: RAM; Similar sites found with APoc: 41
This union binding pocket(no: 2) in the query (biounit: 2zx2.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 2ZQO NGA None
2 4BUZ OAD None
3 4BUZ NAD None
4 4BUZ OCZ None
5 2BW7 APC 1.02564
6 5CB3 APR 1.63934
7 6A0S HSE 2.05128
8 6A0S NDP 2.05128
9 1GQG DCD 2.5641
10 2FAV APR 2.77778
11 1N0U SO1 3.07692
12 4C5N PXL 3.58974
13 4C5N ACP 3.58974
14 6B92 SAH 3.58974
15 3C88 ARG ARG GLY CYS NH2 4.10256
16 1VB3 KPA 4.10256
17 5X5U NAD 4.10256
18 1ME8 RVP 4.61538
19 2IV2 2MD 4.61538
20 4RUS NAG 4.61538
21 3KJS NAP 5.12821
22 3NBC LAT 5.40541
23 3JQ9 NAP 5.64103
24 3HRD MCN 6.15385
25 3EWR APR 6.54762
26 1S8G DAO 6.61157
27 1S7G NAD 7.17949
28 3GAY P6T 8.20513
29 2AWN ADP 8.71795
30 1F76 ORO 8.71795
31 2P8O BVA 9.16031
32 3OVR 5SP 9.23077
33 2BFR ADP 9.375
34 2Z48 NGA 9.74359
35 2Z48 A2G 9.74359
36 2C3H GLC GLC 13.2653
37 5MDH NAD 13.3333
38 5TCI 79V 16.4103
39 5AE2 FYC 17.4359
40 5AE2 FAD 17.4359
41 1B4P GPS 20.5128
Pocket No.: 3; Query (leader) PDB : 2ZX2; Ligand: RAM; Similar sites found with APoc: 82
This union binding pocket(no: 3) in the query (biounit: 2zx2.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 3BF1 PAU None
2 1L6O SER LEU LYS LEU MET THR THR VAL None
3 2ART LPA AMP None
4 1G16 GDP None
5 3H8V ATP None
6 3GDH SAH None
7 1YRB GDP 1.53846
8 1OS7 AKG 2.05128
9 1OS7 TAU 2.05128
10 6GAR FAD 2.5641
11 5VAH SAH 2.5641
12 1CX9 NHP 3.07692
13 1YKJ FAD 3.07692
14 3TMK T5A 3.07692
15 1NN5 2DT 3.07692
16 1NN5 ANP 3.07692
17 1H2B NAJ 3.07692
18 4C2X NHW 3.07692
19 2I7C AAT 3.07692
20 5O2T GSP 3.5503
21 4P53 NAI 3.58974
22 1LVK MNT BEF 3.58974
23 2VG1 FPP 3.58974
24 1GZ4 ATP 3.58974
25 2WK9 PLP 3.58974
26 5FVJ ACO 3.61446
27 4WZA ADP 4.10256
28 2XTN GTP 4.10256
29 4LTN NAI 4.10256
30 3FV1 DYH 4.10256
31 4YBN FAD 4.10256
32 5L3R GCP 4.10256
33 5ZXD ATP 4.61538
34 2CHG ANP 4.61538
35 4RUS NDG 4.61538
36 5OWC AYZ 4.91803
37 1Q9I TEO 5.12821
38 1Q9I FAD 5.12821
39 3NC9 TR3 5.12821
40 4RDH AMP 5.12821
41 1F28 UMP 5.12821
42 2UZI GTP 5.26316
43 1M4I PAP 5.52486
44 1M4I KAN 5.52486
45 1M4I COA 5.52486
46 6B4K ANP 5.64103
47 1NV8 SAM 5.64103
48 1ON3 MCA 5.64103
49 4NCN GTP 5.64103
50 5BN3 ADP 5.64103
51 1OXV ANP 6.15385
52 5HM3 649 6.15385
53 2YNC YNC 6.15385
54 3ZLB ANP 6.15385
55 1XVA SAM 6.15385
56 4P5E N6P 6.57895
57 1DQS NAD 6.66667
58 1P72 ADP 7.17949
59 1Y8Q ATP 7.17949
60 2RDT 2RD 7.17949
61 5AK0 8V1 7.69231
62 5HMY LNY 7.69231
63 4MSG 2C6 8.71795
64 1Y3A GDP 9.74359
65 6CRK GDP 9.74359
66 3VPH NAD 9.74359
67 5UWS GNP 9.74359
68 5UWT GNP 9.74359
69 4QRH 0O2 9.74359
70 5UWQ GNP 9.74359
71 5UWP GNP 9.74359
72 5DHF GNP 9.74359
73 3KJQ B94 9.7561
74 2ODE ALF GDP 10.2564
75 1N46 PFA 10.2564
76 3WR7 COA 10.5882
77 4R57 ACO 10.7955
78 2BIF ANP 13.8462
79 1Z2P I3S 14.359
80 1Z2P ACP 14.359
81 2WTX UDP 18.9744
82 6APL C5P 21.0256
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