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Receptor
PDB id Resolution Class Description Source Keywords
2ZV2 2.4 Å EC: 2.7.11.17 CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENT PROT KINASE 2, BETA, CAMKK2 KINASE DOMAIN IN COMPLEX WITH STO-60 HOMO SAPIENS CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 2 BETA CAMKK2 E.C.2.7.11.17 PHOSPHORYLATION AMPKK METABOLISM BINDING KINASE CALMODULIN-BINDING NUCLEOTIDE-BINDING PHOSPHOPROTEIN SERINE/THREONINE-PROTEIN KINASE TRANSFERASSTRUCTURAL GENOMICS NPPSFA NATIONAL PROJECT ON PROTEIN STAND FUNCTIONAL ANALYSES RIKEN STRUCTURAL GENOMICS/PROTEOMIINITIATIVE RSGI TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: CRYSTAL STRUCTURE OF THE CA2+/CALMODULIN-DEPENDENT KINASE KINASE IN COMPLEX WITH THE INHIBITOR STO-609 J.BIOL.CHEM. V. 286 22570 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
609 A:501;
Valid;
none;
submit data
314.294 C19 H10 N2 O3 c1ccc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2ZV2 2.4 Å EC: 2.7.11.17 CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENT PROT KINASE 2, BETA, CAMKK2 KINASE DOMAIN IN COMPLEX WITH STO-60 HOMO SAPIENS CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 2 BETA CAMKK2 E.C.2.7.11.17 PHOSPHORYLATION AMPKK METABOLISM BINDING KINASE CALMODULIN-BINDING NUCLEOTIDE-BINDING PHOSPHOPROTEIN SERINE/THREONINE-PROTEIN KINASE TRANSFERASSTRUCTURAL GENOMICS NPPSFA NATIONAL PROJECT ON PROTEIN STAND FUNCTIONAL ANALYSES RIKEN STRUCTURAL GENOMICS/PROTEOMIINITIATIVE RSGI TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: CRYSTAL STRUCTURE OF THE CA2+/CALMODULIN-DEPENDENT KINASE KINASE IN COMPLEX WITH THE INHIBITOR STO-609 J.BIOL.CHEM. V. 286 22570 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 2ZV2 - 609 C19 H10 N2 O3 c1ccc2c(c1....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2ZV2 - 609 C19 H10 N2 O3 c1ccc2c(c1....
2 6CMJ ic50 = 5 nM F6J C24 H22 N2 O2 CC(C)Cc1cc....
50% Homology Family (420)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 3IGO - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 3NCG - BK1 C19 H19 N5 CC(C)n1c2c....
3 3MWU - BK3 C22 H24 N6 c1ccc2c(c1....
4 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
5 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
6 6FCK ic50 = 0.031 uM D4Z C20 H22 N4 O c1ccc(cc1)....
7 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
8 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
9 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
10 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
11 5OQ7 ic50 = 0.8743 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
12 5F4N ic50 = 2.2 nM 5UY C17 H19 N7 O3 COC(=O)c1c....
13 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
14 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
15 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
16 5OP5 ic50 = 0.4964 uM 3FE C17 H15 N5 O c1cc(cc(c1....
17 3NLB ic50 = 35 nM 5BE C21 H28 N6 O Cc1c(c([nH....
18 3JVR Ki = 1.89 uM AGX C16 H13 Cl2 N3 O2 C[C@@H](c1....
19 2WMX ic50 = 0.86 uM ZY6 C17 H19 N5 O c1ccc(cc1)....
20 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
21 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
22 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
23 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
24 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
25 5OP7 - A1K C19 H21 Cl N6 O3 CNc1c2c(c[....
26 5OOP - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
27 5OPR ic50 = 5.8506 uM A3E C21 H26 N6 O CC(C)n1cc(....
28 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
29 5OQ5 ic50 = 0.052 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
30 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
31 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
32 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
33 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
34 5OQ8 ic50 = 4.0577 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
35 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
36 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
37 5OPS ic50 = 1.9827 uM A3Q C14 H9 N3 O c1cc(cc(c1....
38 3JVS Ki = 0.146 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
39 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
40 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
41 2C3L Ki = 0.026 uM IDZ C14 H10 N4 c1ccc2c(c1....
42 5OP2 ic50 = 0.5543 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
43 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
44 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
45 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
46 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
47 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 C[C@@]12[C....
48 5OOR - STU C28 H26 N4 O3 C[C@@]12[C....
49 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
50 4RVK ic50 = 13.5 nM 3XK C19 H13 N5 O CC(=O)Nc1c....
51 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
52 6FC8 ic50 = 0.012 uM D4Q C19 H19 F N4 O S c1cc(cc(c1....
53 3LFN Ki = 3160 nM A27 C23 H21 N3 O2 CCCC(=O)Nc....
54 3PY1 Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
55 2A4L ic50 = 0.4 uM RRC C19 H26 N6 O CC[C@H](CO....
56 1Y8Y ic50 = 2 uM CT7 C13 H11 Cl N4 O2 S CS(=O)(=O)....
57 6GUH Kd = 26 nM FB8 C18 H21 N5 O2 S Cc1ncc(n1C....
58 1OIR ic50 = 0.032 uM HDY C23 H26 N6 O2 Cc1c(n2ccc....
59 1PXJ - CK2 C9 H10 N4 S Cc1c(sc(n1....
60 2VTO ic50 = 0.14 uM LZ8 C17 H13 F N4 O2 c1ccc(cc1)....
61 2BTR ic50 = 95 nM U73 C13 H15 N3 O S CC(C)C1=CN....
62 2VTA ic50 = 185 uM LZ1 C7 H6 N2 c1ccc2c(c1....
63 3EZR - EZR C26 H27 N7 O CN1CCN(CC1....
64 3ULI ic50 = 0.07 uM 1N3 C21 H25 Br N6 O2 COc1ccc(cc....
65 2DS1 ic50 = 6.4 nM 1CD C22 H21 N5 O3 C[C@@H]1C[....
66 5FP5 - 1Y6 C7 H5 F O2 c1cc(ccc1C....
67 2VTH ic50 = 120 uM LZ2 C10 H9 N O3 S c1cc2c(ccc....
68 1KE5 ic50 = 560 nM LS1 C16 H15 N3 O3 S CNS(=O)(=O....
69 3FZ1 - B98 C13 H15 N3 O2 S COc1ccc2c(....
70 1WCC ic50 = 350 uM CIG C4 H4 Cl N3 c1c(nc(cn1....
71 1PXO Ki = 2 nM CK7 C14 H12 N6 O2 S Cc1c(sc(n1....
72 1H00 ic50 = 38 uM FAP C21 H23 F2 N5 O2 CN(C)C[C@@....
73 2R3R - 6SC C18 H14 Br N5 c1ccc(cc1)....
74 1B39 Kd = 0.12 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
75 3PXF Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
76 3TI1 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
77 2R3G ic50 = 800 nM SC9 C18 H14 F N5 c1ccc(c(c1....
78 2C69 ic50 = 26 uM CT8 C17 H14 Br N6 c1cc(cc(c1....
79 2VTM ic50 ~ 1 mM LZM C7 H4 N4 c1cnc2c(cn....
80 4ERW - STU C28 H26 N4 O3 C[C@@]12[C....
81 1E1V Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
82 2VV9 ic50 = 0.017 uM IM9 C23 H29 N7 O2 Cc1ncc(n1C....
83 5IEV - R0N C18 H23 F3 N4 O3 S C[C@H]([C@....
84 4D1X - ESJ C11 H8 N2 O3 S2 c1cc2c(cc1....
85 5MHQ - 8QT C19 H27 N7 O CC[C@@H]([....
86 2BTS ic50 = 20 nM U32 C12 H15 N3 O2 S2 CC(C)c1cnc....
87 1URW ic50 < 0.003 uM I1P C21 H24 N8 O2 S CN(C)CCCNS....
88 5FP6 - MFZ C11 H7 Cl2 N O c1cc(c2c(c....
89 1CKP - PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
90 1KE6 ic50 = 5.7 nM LS2 C17 H15 N5 O3 S2 CNS(=O)(=O....
91 2C6K ic50 = 0.73 uM DT2 C17 H21 N7 O2 S c1cc(ccc1N....
92 2R3Q - 5SC C19 H16 Br N5 O Cc1ccccc1c....
93 1OIT ic50 < 0.003 uM HDT C17 H14 N6 O2 S c1ccn2c(c1....
94 3NS9 ic50 = 0.003 uM NS9 C20 H27 N5 O3 CC(C)c1cnn....
95 1H01 ic50 = 22 uM FAL C21 H23 Cl2 N5 O2 CN(C)C[C@H....
96 2EXM - ZIP C10 H13 N5 CC(=CCNc1c....
97 4BGH ic50 = 4 nM 3I6 C13 H16 Br N5 O3 S C[C@H](CO)....
98 2R3F ic50 = 500 nM SC8 C18 H13 Cl2 N5 c1cc(c(c(c....
99 1GII - 1PU C17 H16 N4 O2 c1ccnc(c1)....
100 2R64 ic50 = 0.03 uM 740 C23 H27 N5 O3 S c1cc(ccc1C....
101 5A14 - LQ5 C24 H26 F3 N7 O2 CN1CCN(CC1....
102 2C6L ic50 = 0.27 uM DT4 C17 H22 N8 O2 S c1cc(ccc1N....
103 2W06 - FRV C18 H20 N6 O2 S Cc1ncc(n1C....
104 4EZ7 - STU C28 H26 N4 O3 C[C@@]12[C....
105 5D1J ic50 = 48 nM 56H C17 H24 N4 O2 S2 CC(C)(C)c1....
106 5IEY - 6AE C14 H19 N5 O3 S C[C@H]([C@....
107 2VTT ic50 = 0.044 uM LZD C16 H17 F2 N5 O2 c1cc(c(c(c....
108 2VU3 ic50 = 0.047 uM LZE C16 H17 Cl2 N5 O2 c1cc(c(c(c....
109 2B54 - D05 C20 H15 Cl3 N4 O3 CCc1c2c(n(....
110 1GZ8 - MBP C10 H13 N5 O2 CC(C)C(=O)....
111 3PY0 ic50 = 0.13 uM SU9 C13 H11 N3 O2 COc1ccc2c(....
112 2VTR ic50 = 1.5 uM LZB C10 H10 Cl N5 CC(C)Nc1cc....
113 1E1X Ki = 1.3 uM NW1 C11 H17 N5 O2 C1CCC(CC1)....
114 3UNJ ic50 = 11 uM 0BX C17 H14 N4 O2 c1ccc(cc1)....
115 2A0C - CK9 C19 H26 N6 O2 CC[C@H](CO....
116 3TIY - TIY C11 H8 O5 c1c2c(c(c(....
117 2R3I ic50 = 1000 nM SCF C18 H14 F N5 c1ccc(c(c1....
118 1VYZ ic50 = 290 nM N5B C13 H13 N3 O c1ccc(cc1)....
119 3WBL ic50 = 23 uM PDY C20 H26 N6 O CCOc1ccc(c....
120 4RJ3 ic50 = 93 nM 3QS C22 H28 N6 O COC1CCN(CC....
121 2VTN ic50 = 0.85 uM LZ7 C12 H11 F N4 O2 CC(=O)Nc1c....
122 1AQ1 - STU C28 H26 N4 O3 C[C@@]12[C....
123 2C6M ic50 = 0.35 uM DT5 C17 H20 N6 O3 S c1cc(ccc1N....
124 2R3L ic50 = 100 nM SCW C18 H14 Br N5 c1ccc(cc1)....
125 1H08 - BYP BWP n/a n/a
126 1B38 Kd = 0.254 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
127 2B52 ic50 = 8 nM D42 C21 H23 N7 O2 S Cc1c(sc(n1....
128 1PXL - CK4 C16 H13 F3 N4 S Cc1c(sc(n1....
129 3S2P ic50 = 0.068 uM PMU C17 H22 N4 O3 CC(C)c1cc(....
130 2R3O ic50 = 600 nM 2SC C19 H17 N5 O c1ccc(cc1)....
131 3IGG ic50 = 95 nM EFQ C16 H19 N3 O3 COc1ccc(cc....
132 1R78 ic50 = 3 nM FMD C20 H20 F N3 O4 C[C@H]([C@....
133 2FVD Ki = 0.003 uM LIA C18 H21 F2 N5 O4 S COc1ccc(c(....
134 2VTL ic50 = 97 uM LZ5 C10 H9 N3 O c1ccc(cc1)....
135 1KE9 ic50 = 660 nM LS5 C16 H15 N5 O3 S c1ccc2c(c1....
136 1PYE ic50 = 0.32 uM PM1 C21 H13 F2 N3 O2 c1ccc(cc1)....
137 4EZ3 - 0S0 C11 H10 N4 O4 S c1cc(ccc1/....
138 1H07 ic50 = 3 uM MFP C24 H27 Br N6 O2 Cc1ccc(c(c....
139 2B53 ic50 = 0.6 uM D23 C19 H19 F3 N4 CC(C)(C)Nc....
140 6GUK Kd = 725 nM FC8 C19 H24 Cl N7 CCn1cnc2c1....
141 2DUV ic50 = 0.087 uM 371 C19 H17 N O7 S Cc1cc2c(c(....
142 4D1Z - WG8 C13 H10 N2 O3 S c1cc2ccc(n....
143 4ACM Ki = 210 nM 7YG C20 H23 N7 O3 S CN(C)CCNS(....
144 2C5Y ic50 = 0.25 uM MTW C19 H15 N7 O2 c1cc(cc(c1....
145 2R3K ic50 = 100 nM SCQ C18 H14 Br N5 c1ccc(cc1)....
146 2V0D - C53 C9 H7 N3 O S [H]/N=C1/N....
147 2W1H ic50 = 0.052 uM L0F C17 H13 N5 O c1ccc(cc1)....
148 1Y91 ic50 = 0.059 uM CT9 C23 H33 N7 O2 S CC(C)c1cnn....
149 4FII - ARG PRO LYS PRO LEU VAL ASP PRO n/a n/a
150 4NJD ic50 = 0.79 uM NJD C21 H20 N8 O COc1nc(nc(....
151 4JDK - ARG ARG ARG ARG SER TRP TYR n/a n/a
152 5XVG Ki = 0.009 uM 8FX C20 H22 Cl N7 O C[C@@H]1CN....
153 2ZV2 - 609 C19 H10 N2 O3 c1ccc2c(c1....
154 4ONA ic50 = 0.002 uM UW1 C19 H23 N5 O2 CCOc1ccc2c....
155 4JBV ic50 = 0.003 uM V68 C26 H32 N6 O CC(C)COc1c....
156 3NYV - DTQ C16 H15 N3 O3 COc1cc2c(c....
157 3T3U Ki = 0.0025 uM BK6 C22 H24 N6 O COc1ccc2cc....
158 3KU2 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
159 4M84 ic50 = 0.049 uM 21E C17 H19 N5 O CC(C)(C)n1....
160 3HX4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
161 3UPX Ki = 0.0075 uM B6A C20 H22 N4 O c1ccc(cc1)....
162 3SXF Ki = 0.0025 uM BK5 C20 H21 N5 O CCOc1ccc2c....
163 3T3V Ki = 0.003 uM BK4 C19 H19 N5 O CC(C)n1c2c....
164 3I7B ic50 = 0.066 uM BK1 C19 H19 N5 CC(C)n1c2c....
165 3V5P Ki = 0.011 uM C88 C19 H24 N6 O Cc1cc(ccc1....
166 3V51 - I76 C25 H22 Cl N5 O CC(C)n1c2c....
167 3UPZ - B5A C11 H16 N6 c1c2c(ncnc....
168 3I7C ic50 = 0.018 uM BK2 C19 H19 N5 CC(C)(C)n1....
169 3V5T - UW9 C24 H30 N6 O CCOc1ccc2c....
170 3N51 - BK3 C22 H24 N6 c1ccc2c(c1....
171 5OTO - AQW C24 H23 Cl2 N3 CCc1ccccc1....
172 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
173 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
174 6EII - B5W C22 H23 Cl N c1ccc(cc1)....
175 5CU0 - 54R C18 H21 Cl N2 O CC(=O)NCCC....
176 5H8E ic50 < 0.003 uM 5Y3 C21 H25 N9 O CC(=O)Nc1c....
177 5OWH - B0K C10 H9 Br4 N3 c1nc2c(n1C....
178 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
179 5MOE Kd = 500 uM OQC C11 H10 Cl N O c1cc(c(cc1....
180 5OUE - AVZ C18 H19 Cl N3 c1ccc(cc1)....
181 5MOD Kd = 300 uM 86L C10 H14 Cl N O CC(C)Oc1cc....
182 5OWL - B0K C10 H9 Br4 N3 c1nc2c(n1C....
183 5CU3 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
184 5OTR - AU8 C13 H12 Cl2 N c1ccc(cc1)....
185 4KWP Ki = 0.04 uM EXX C12 H10 Br4 N2 O3 c1nc2c(n1[....
186 5OSL - A9K C13 H12 Cl N O c1ccc(c(c1....
187 5N9N Ki = 0.4 nM KC5 C20 H15 Cl2 N O4 COc1ccc(cc....
188 5CSP Kd = 58 uM 54G C8 H8 O3 Cc1ccc(c(c....
189 5CTP - 54R C18 H21 Cl N2 O CC(=O)NCCC....
190 5MOW - BR9 C5 H6 Br N3 c1c(cnc(c1....
191 4UB7 Ki = 2.5 nM 3G5 C16 H8 Br2 O5 c1cc(ccc1C....
192 5MMF - JMB C16 H19 Cl N CCC[NH2+]C....
193 5OTH - AQ8 C25 H26 Cl N3 O CCc1ccccc1....
194 1PJK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
195 3NSZ - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
196 5OTI - AOK C25 H26 Cl N3 CCc1ccccc1....
197 3AXW - TID C9 H7 N3 O2 S c1cc(ccc1c....
198 5MO6 - KXZ C19 H21 Cl N2 O3 c1ccc(cc1)....
199 2PVR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
200 3C13 - EMO C15 H10 O5 Cc1cc2c(c(....
201 5CS6 Kd = 630 uM K82 C10 H14 Cl N O CCCOc1ccc(....
202 3PE2 Ki = 0.175 nM E1B C20 H12 N4 O2 C#Cc1cccc(....
203 5CT0 - 54P C16 H18 Cl N O c1ccc(cc1)....
204 5CU6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
205 5M4C - 7EY C16 H14 N2 O2 S2 Cc1ccc(cc1....
206 5MO7 - YRA C16 H17 Cl N2 O c1ccc(cc1)....
207 5N9L Ki = 15 nM 8QH C20 H15 Cl2 N O3 Cc1ccc(cc1....
208 5OT5 - AWK C25 H26 Cl N3 CCc1ccccc1....
209 3OWK ic50 = 1.5 uM 18E C16 H11 Cl N2 O Cc1cnc(c2c....
210 5MMR - H83 C17 H21 Cl N2 c1ccc(cc1)....
211 5MPJ - J2P C15 H17 Cl N CC[NH2+]Cc....
212 5OQU - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
213 6GIH - EZN C15 H13 Cl N2 c1cc(c2cc[....
214 5CSV - GAB C7 H7 N O2 c1cc(cc(c1....
215 5MOT - HBD C7 H7 N O2 c1cc(ccc1C....
216 3R0T ic50 = 0.91 nM FU9 C22 H16 F3 N5 O2 c1cc(cc(c1....
217 3PE1 Ki = 0.38 nM 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
218 3JUH - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
219 5CLP - 42J C8 H9 Cl2 N c1cc(c(cc1....
220 5ORH Kd = 41 uM A4N C14 H14 Cl N Cc1ccccc1c....
221 3H30 Ki = 29.2 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
222 2ZJW ic50 = 0.04 uM REF C14 H6 O8 c1c2c-3c(c....
223 5OSZ - AHK C24 H25 Cl N3 CCc1ccccc1....
224 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
225 5OT6 - AJK C19 H20 Cl N2 c1ccc(cc1)....
226 6EHK - AUW C24 H23 Cl2 N3 CCc1ccccc1....
227 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
228 5OS8 - J27 C14 H14 Cl F N Cc1cc(ccc1....
229 5OTY - AUW C24 H23 Cl2 N3 CCc1ccccc1....
230 5OTD - AOW C24 H24 Cl N4 O2 CCc1ccccc1....
231 6GMD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
232 5CVF - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
233 5CX9 - 551 C20 H23 Cl N2 O3 COC(=O)CC(....
234 5OUL - AWE C13 H11 Cl F N c1cc(cc(c1....
235 3SHE - I85 C24 H22 F3 N5 O2 c1cc(cc(c1....
236 5IZJ - 6J9 C10 H13 N5 c1c[nH]c2c....
237 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 [H]/N=C(N)....
238 5IZF Kd = 1.7 nM 6J9 AZ1 DAR ACA DAR NH2 n/a n/a
239 2VZ6 - FEF C20 H19 N3 O4 c1ccc2c(c1....
240 2Z7R ic50 = 3 nM STU C28 H26 N4 O3 C[C@@]12[C....
241 4J8M ic50 = 48 nM CJ5 C26 H25 F3 N8 O c1cc(cc(c1....
242 5ORO - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
243 5OS4 Kd = 1665 uM A8H C14 H15 N O2 c1ccc(cc1)....
244 6HJJ ic50 = 1.7 uM G7T C26 H24 F4 N6 O2 Cc1cc(ccc1....
245 5ORS - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
246 5ORL - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
247 5DR9 - 5E2 C16 H9 Br Cl N O2 c1cc(cc(c1....
248 4DEA ic50 = 256 nM NHI C18 H14 N4 O4 c1cc(ccc1C....
249 5DN3 Kd = 3.77 uM 5DN C16 H9 Br F N O2 c1cc(cc(c1....
250 5ORP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
251 4DEE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
252 5OSE Kd = 681 uM A98 C6 H9 N3 O2 S2 CCSc1nnc(s....
253 5DNR - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
254 3UOD Kd = 49 nM 0C3 C18 H13 F3 N4 O2 c1ccc(c(c1....
255 3EFW - AK8 C25 H21 F3 N6 O2 Cc1cc(ccc1....
256 5DT0 - SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
257 3UO4 Kd = 299 nM 0C0 C23 H18 N4 O2 c1ccc(cc1)....
258 3UP2 Kd = 40 nM 0C8 C18 H13 F3 N4 O3 c1ccc(c(c1....
259 5ORX ic50 = 308 uM A6H C11 H8 Cl2 N2 O c1cc(c(c(c....
260 5ORN - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
261 5OS5 ic50 = 108 uM A8K C12 H10 O2 S c1cc(ccc1O....
262 5DR2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
263 3DJ5 - AK5 C21 H20 Br N5 O3 S COc1ccc(cc....
264 3UOL ic50 = 3.1 nM 0C7 C17 H13 Cl N8 c1ccc(c(c1....
265 3D14 ic50 = 22 nM AK1 C19 H15 F3 N6 O S2 c1cc(cc(c1....
266 5OSD - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
267 5OS2 Kd = 1821 uM A7K C13 H21 N2 O c1ccc(c(c1....
268 4BN1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
269 2NP8 ic50 = 42 nM CC3 C21 H18 F3 N5 O c1cc(cc(c1....
270 5ORR ic50 = 899 uM A5Q C9 H6 F3 N3 S c1cc(ccc1c....
271 4JBQ - VX6 C23 H28 N8 O S Cc1cc([nH]....
272 5OS3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
273 5DRD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
274 5DPV - SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
275 5ORZ ic50 = 245 uM A6W C10 H9 N O2 S2 COC(=O)c1c....
276 4UYN ic50 = 2 nM Y3M C25 H22 N4 O4 S CCOC(=O)c1....
277 5DT3 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
278 2WTV Ki = 1.8 nM ZZL C25 H15 Cl F2 N4 O2 c1cc(c(c(c....
279 6HJK ic50 = 25 nM G7W C25 H20 F4 N6 O2 CC(C)n1c2c....
280 3O50 - LJE C24 H17 F3 N4 O2 Cc1cc(ccc1....
281 2J4Z ic50 = 65 nM 626 C23 H24 N6 O2 S CN1CCN(CC1....
282 3LAU ic50 = 0.044 uM OFI C17 H17 N3 O2 CCCC(=O)Nc....
283 3DAJ ic50 = 2.9 uM FXG C22 H29 N7 O2 CCCCNC(=O)....
284 4JBO ic50 = 24 nM WPH C31 H32 N6 O3 CN(C)CCOc1....
285 5ORW Kd = 796 uM A6E C13 H16 F N O2 S c1cc(ccc1O....
286 2C6D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
287 5OS0 Kd = 2792 uM A6Z C12 H15 Cl N3 c1cc(cc(c1....
288 3K5U ic50 = 309 nM PFQ C20 H17 N3 O2 c1ccc(cc1)....
289 4KS7 - X4Z C25 H28 N8 O S Cc1nc2ccsc....
290 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
291 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
292 2OXY - K17 C7 H2 Br4 N2 c1[nH]c2c(....
293 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
294 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
295 1ZOE Ki = 0.04 uM K25 C9 H7 Br4 N3 CN(C)c1[nH....
296 2PVL Ki = 0.024 uM P55 C18 H20 N8 CCN1CCN(CC....
297 1LP4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
298 2PVN Ki = 0.00035 uM P63 C20 H16 N8 O CC(=O)Nc1c....
299 3KXG - K6X C7 H Br5 N2 c12c(c(c(c....
300 3BE9 Ki = 24 nM P04 C19 H21 N7 O c1cc2cc(c1....
301 2OXX - K22 C7 H2 Br4 N2 S c12c(c(c(c....
302 3KXM - K74 C11 H9 Br4 N3 O S CNC(=O)CSc....
303 1LR4 - BEN C7 H8 N2 [H]/N=C(c1....
304 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
305 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 C[N@@]1CCn....
306 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
307 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
308 3EH9 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
309 1IG1 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
310 5AUW ic50 = 8.9 uM QUE C15 H10 O7 c1cc(c(cc1....
311 5AV2 - KMP C15 H10 O6 c1cc(ccc1C....
312 5AUU ic50 = 21 uM LU2 C15 H10 O6 c1cc(c(cc1....
313 3EHA - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
314 5AV3 - KMP C15 H10 O6 c1cc(ccc1C....
315 5AUT Kd = 6.7 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
316 5AV0 ic50 = 280 uM 47X C15 H10 O5 c1cc(c(cc1....
317 1JKK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
318 3F5U - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
319 5AV4 - GEN C15 H10 O5 c1cc(ccc1C....
320 5AUX ic50 = 10 uM KMP C15 H10 O6 c1cc(ccc1C....
321 5AUV ic50 = 31 uM AGI C15 H10 O5 c1cc(ccc1C....
322 2XK6 - EQH C18 H21 N3 O2 S c1csc(c1C2....
323 2W5A - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
324 5M55 ic50 = 0.24 uM 7GG C17 H20 N6 CCN(CC)/C=....
325 2XNM ic50 = 0.16 uM WGZ C27 H27 F3 N4 O3 S C[C@H](c1c....
326 2XKF ic50 = 0.87 uM BX1 C19 H24 N4 O5 COc1cc(cc(....
327 2JAV ic50 ~ 8 uM 5Z5 C17 H16 Cl N3 O2 Cc1c([nH]c....
328 5M53 ic50 = 0.62 uM 7GJ C21 H26 N6 O2 CN(C)C(=O)....
329 2XK8 ic50 = 2.4 uM 5R1 C21 H21 N3 O6 COc1cc(ccc....
330 2WQO - VGK C21 H20 N2 O5 COc1cc(cc(....
331 2XKE ic50 = 4.2 uM WI2 C17 H20 N4 O3 COc1cccc(c....
332 2XNN - 430 C21 H16 F3 N3 O2 S C[C@H](c1c....
333 2XK7 ic50 = 1.5 uM 30E C21 H28 N4 O5 CC[C@H]1C[....
334 1Z5M ic50 = 30 nM LI8 C23 H31 Br N8 O3 CC(C)(C(=O....
335 5HKM ic50 = 0.013 uM 61Y C16 H15 N7 CCc1cc(nc(....
336 3QD0 ic50 = 0.00000001 M 3Q4 C24 H26 N8 O C[C@@H]1CC....
337 3ORZ - BI4 C27 H26 N4 O2 C[N@]1CCC[....
338 5LVN Kd = 20 uM ADN C10 H13 N5 O4 c1nc(c2c(n....
339 2XCH ic50 = 374 nM CKG C22 H25 N7 O c1c2c(nc(n....
340 4AW0 - MJF C18 H15 Cl O5 c1ccc(cc1)....
341 3OTU - BI4 C27 H26 N4 O2 C[N@]1CCC[....
342 3QCX ic50 = 0.00000001 M 3Q2 C16 H19 N7 O C[C@@H]1CO....
343 1UU3 ic50 = 0.75 uM LY4 C28 H28 N4 O3 CN(C)C[C@@....
344 5LVL Kd = 1.25 uM 537 C14 H8 N2 O c1ccc2c(c1....
345 3QC4 ic50 = 0.002 uM MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
346 3QCY ic50 = 0.00000001 M 3Q3 C22 H22 N8 O2 c1ccc(cc1)....
347 1UU8 ic50 = 9 uM BI1 C25 H24 N4 O2 CN(C)CCCn1....
348 4CT1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
349 4A07 - AZ7 C17 H13 Cl3 N2 O2 c1cc(ccc1[....
350 2X39 ic50 = 30 nM X39 C19 H21 Cl N6 O c1cc(ccc1C....
351 3E87 - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
352 4QNA ic50 = 0.023 uM X11 C9 H9 N5 O c1ccc(c(c1....
353 4QMO ic50 = 0.019 uM 34L C13 H8 N4 O S c1cc2c(c3c....
354 4QMW ic50 = 0.086 uM KS1 C17 H17 N7 c1c[nH]c2c....
355 3A7H - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
356 4QML - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
357 4QO9 ic50 = 0.16 uM 627 C26 H30 N6 O3 CN1CCN(CC1....
358 4QMQ ic50 = 0.26 uM 34U C24 H27 N5 O2 COCCOc1ccc....
359 4EL9 - AFE C21 H20 O10 C[C@H]1[C@....
360 5D9L ic50 = 0.024 uM 583 C15 H12 N2 O2 c1cc(ccc1c....
361 2XK9 ic50 = 0.03 nM XK9 C18 H17 N7 O4 C/C(=NNC(=....
362 2YCS ic50 = 1.36 nM NXP C18 H18 N6 O C/C(=NNC(=....
363 2WTI ic50 = 0.092 uM WTI C18 H15 N3 O3 S c1cc(ccc1c....
364 2YIR ic50 = 0.17 nM YIR C20 H19 N7 O3 [H]/N=C(N)....
365 2XBJ ic50 = 0.86 uM XBJ C23 H27 F N4 O4 CC(C)([C@@....
366 2XM9 ic50 = 0.009 uM LWH C21 H20 N6 O c1ccc2c(c1....
367 2YIQ ic50 = 12.67 nM YIQ C20 H19 N7 O C/C(=NNC(=....
368 2CN5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
369 3HZT - J60 C22 H27 Cl N4 O2 CCN(CC)CCN....
370 4FG8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
371 5L2S - 6ZV C27 H32 F2 N8 CCN1CCN(CC....
372 4AUA ic50 = 7.2 uM 4AU C12 H9 N3 O c1ccc2c(c1....
373 5K00 ic50 = 7.1 nM 6PV C32 H34 N6 O4 COc1cccc(c....
374 5MAG - 7KC C25 H30 N8 O S Cc1nc2ccsc....
375 5IHC ic50 = 0.013 uM 6BB C20 H21 F N4 O c1ccc(c(c1....
376 6BUU - GLY ARG PRO ARG THR THR ZXW PHE ALA GLU n/a n/a
377 3QKM ic50 = 0.038 uM SM9 C31 H43 N5 O4 S CCOCCN(C[C....
378 3CQU ic50 = 151 nM CQU C15 H13 N7 Cc1[nH]c(n....
379 2WEI ic50 = 3.4 nM VGG C17 H21 N5 Cc1cccc(c1....
380 3C0G - 3AM C10 H14 N5 O7 P c1nc(c2c(n....
381 3MFR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
382 4OTI ic50 = 43 nM MI1 C16 H20 N6 O C[C@@H]1CC....
383 3OFM - 4B0 C9 H7 Br4 N3 O C(Cn1c2c(c....
384 5YF9 - NIO C6 H5 N O2 c1cc(cnc1)....
385 5ONI - 9YE C23 H25 N O3 CC(C)n1c2c....
386 3WF7 ic50 = 206 nM FS9 C18 H17 F3 N6 O c1cc(cc(c1....
387 4L3J - 5FI C19 H21 F3 N6 CCc1cncnc1....
388 3WF6 ic50 = 33 nM FZ9 C18 H16 N6 c1ccc2c(c1....
389 4AU8 ic50 = 551 nM Z3R C11 H8 N2 O2 S3 c1ccc2c(c1....
390 6B16 Ki = 32 nM C7Y C19 H20 N8 C[C@@H](c1....
391 5DFP Ki = 22 nM 59U C28 H32 Cl N7 O CCN1c2c(cn....
392 3FXZ ic50 = 130 nM FLL C30 H18 Cl F N5 O4 Ru c1ccc(cc1)....
393 5IME Ki = 4.6 nM 6BZ C22 H22 Cl N7 O2 CC1=NC=CN(....
394 4ZY6 Ki = 5 nM 4T6 C18 H17 Cl N8 c1cc2c(c(c....
395 3Q53 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
396 4EQC ic50 = 0.008 uM XR1 C29 H28 Cl N7 O S CCN1c2c(cn....
397 5JZJ - AN2 C10 H16 N6 O9 P2 c1nc(c2c(n....
398 5AX9 ic50 = 8 nM 4KT C24 H24 N4 O3 COc1ccc(cc....
399 2J7T - 274 C28 H30 Cl N5 O4 S Cc1c([nH]c....
400 4JQE - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
401 4MWH - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
402 4LFI - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
403 3GGF - GVD C22 H19 N7 c1ccc2c(c1....
404 4U44 ic50 = 0.008 uM 3D9 C17 H13 N5 c1ccc(cc1)....
405 3DAK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
406 1QL6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
407 1PHK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
408 3M2W ic50 < 0.003 uM L8I C23 H21 F N4 O CN1CC2(C1)....
409 3BHY - 7CP C18 H18 Cl2 N4 O Cn1c2c(ccc....
410 2J90 - IZA C18 H16 F N3 O CC(C)(C)c1....
411 5VJA - DUK C14 H12 Cl N5 O2 S C[C@H](C(=....
412 5A6N ic50 = 2.1 uM U7E C7 H7 N5 O2 S c1cc(cc(c1....
413 6CMJ ic50 = 5 nM F6J C24 H22 N2 O2 CC(C)Cc1cc....
414 2VN9 - GVD C22 H19 N7 c1ccc2c(c1....
415 4EJN ic50 = 0.005 uM 0R4 C33 H26 F N7 O2 CC(=O)Nc1c....
416 4WNO ic50 = 160 nM 3RF C20 H19 N7 c1ccc2c(c1....
417 4WNP ic50 = 8 nM 3RJ C22 H20 N8 c1ccc2c(c1....
418 5CI7 ic50 = 120 nM 51W C18 H24 I N7 O c1cc(cc(c1....
419 2V7O - DRN C25 H23 N5 O2 S [H]/N=C(/N....
420 3AQV - TAK C24 H25 N5 O c1cc(ccc1c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 609; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 609 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2ZV2; Ligand: 609; Similar sites found with APoc: 538
This union binding pocket(no: 1) in the query (biounit: 2zv2.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 5VLQ ANP 1.34228
2 3I6B KDO 1.66667
3 3DNT ATP 1.67785
4 2Q4H AMP 1.67785
5 4M26 AKG 1.67785
6 2GQR ADP 1.68776
7 2GQS ADP 1.68776
8 6FL8 ADP 2.01342
9 6FL8 TIY 2.01342
10 3UDZ ADP 2.01342
11 1ZBQ NAD 2.01342
12 4YZ5 SLT 2.01342
13 1P0F NAP 2.01342
14 3CQD ATP 2.01342
15 2GMH FAD 2.01342
16 3P7G MAN 2.05479
17 3K5I ADP 2.23325
18 3K5I AIR 2.23325
19 4KM2 TOP 2.23464
20 1E3W NAD 2.29885
21 4PZ6 GMP 2.34899
22 4MV1 ADP 2.34899
23 4GKV NAD 2.34899
24 2ZYI STE 2.34899
25 3BBD SAH 2.34899
26 2YW2 ATP 2.34899
27 2CDU FAD 2.34899
28 6C8R EQV 2.34899
29 5FI3 NAP 2.34899
30 4CNG SAH 2.35294
31 4ZGP ADP 2.38908
32 4IEN GDP 2.45399
33 3JSX FAD 2.5641
34 3JSX CC2 2.5641
35 3KAL ADP 2.68456
36 1I7L ATP 2.68456
37 5OLK DTP 2.68456
38 4GLW 0XT 2.68456
39 1XHC FAD 2.68456
40 5O98 NAP 2.68456
41 4HA6 FAD 2.68456
42 4O9S 2RY 2.7907
43 1NE6 SP1 2.82686
44 5CUO COA 2.9703
45 5VZ0 ADP 3.02013
46 5TT6 ATP 3.02013
47 1IOW ADP 3.02013
48 1IOW PHY 3.02013
49 4ZS4 ATP 3.02013
50 5TT5 NAD 3.02013
51 4D04 FAD 3.02013
52 4D04 NAP 3.02013
53 1LDN NAD 3.02013
54 5VSM MET 3.02013
55 5ZEC NAP 3.02013
56 5VSM 5AD 3.02013
57 1RYI FAD 3.02013
58 3OVR 5SP 3.07018
59 2QX0 PH2 3.14465
60 2PHN GDP 3.14961
61 4AF5 CIT 3.15789
62 1XKQ NDP 3.21429
63 4JGP PYR 3.22581
64 3SIG AR6 3.2491
65 3PDT ADP 3.27273
66 3RG9 WRA 3.33333
67 1T36 ADP 3.3557
68 4OCV ANP 3.3557
69 2QK4 ATP 3.3557
70 4UWH JXM 3.3557
71 1AUX AGS 3.3557
72 4U98 ACP 3.3557
73 3CGD NAD 3.3557
74 2CFM AMP 3.3557
75 5J60 FAD 3.3557
76 1PK8 ATP 3.3557
77 3VOT ADP 3.52941
78 4FE2 ADP 3.52941
79 2YRX AMP 3.69128
80 1IA9 ANP 3.69128
81 2R7K ACP 3.69128
82 2R7K AMZ 3.69128
83 5A04 BGC 3.69128
84 1CKM GTP 3.69128
85 6EL3 NAP 3.69128
86 1GPE FAD 3.69128
87 4MOP 2H5 3.69128
88 1GZ6 NAI 3.69128
89 3F3E LEU 3.69128
90 5WBF LAC 3.7037
91 1IY8 NAD 3.74532
92 1W2D 4IP 3.77358
93 1W2D ADP 3.77358
94 3D04 SAK 3.77358
95 2BL9 CP6 3.78151
96 2AQX ATP 3.80623
97 3B6C SDN 3.84615
98 3VPD ANP 3.91459
99 6E2B PT7 3.94737
100 4C5N PXL 3.98551
101 4C5N ACP 3.98551
102 2PYW ADP 4.02685
103 2IF8 ADP 4.02685
104 3WO0 ADP 4.02685
105 3WO0 ALA 4.02685
106 4N14 WR7 4.02685
107 3ORQ ADP 4.02685
108 4EIL NDP 4.02685
109 3TY5 ATP 4.02685
110 5KTI TRE 6X6 4.02685
111 3TY5 ADP 4.02685
112 2NPX FAD 4.02685
113 5AHW CMP 4.08163
114 6E8I PTR 4.14201
115 4OUJ LBT 4.23453
116 3LQV ADE 4.34783
117 3W0O ADP 4.36242
118 3W0O HY0 4.36242
119 4LH7 1X8 4.36242
120 3I0O ADP 4.36242
121 5ZCT ANP 4.36242
122 5DXT 5H5 4.36242
123 3V4S ATP 4.36242
124 3V4S ADP 4.36242
125 5TDF ADP 4.36242
126 3AKK ADP 4.36242
127 4CQM NAP 4.36242
128 3HRD FAD 4.39189
129 1MID LAP 4.3956
130 1UZD CAP 4.47761
131 5O96 SAM 4.4898
132 6CGD AKN 4.59016
133 6CGD GNP 4.59016
134 5I35 ANP 4.69799
135 2IO8 ADP 4.69799
136 3HAV ATP 4.69799
137 1E4E ADP 4.69799
138 5OES ADP 4.69799
139 2VPQ ANP 4.69799
140 2HGS ADP 4.69799
141 5IGI ZIT 4.69799
142 5IGI GMP 4.69799
143 2V58 LZJ 4.69799
144 2QF7 AGS 4.69799
145 4W6Z 8ID 4.69799
146 4NJH 2K8 4.69799
147 1IHU AF3 4.69799
148 1IHU ADP 4.69799
149 4NJH SAM 4.69799
150 1GZ4 ATP 4.69799
151 1D2N ANP 4.77941
152 1FFU FAD 4.90798
153 3TM0 B31 4.94297
154 3TM0 ANP 4.94297
155 2RIF AMP 4.96454
156 4XBA 5GP 5
157 1TZD ADP 5.03356
158 4R78 AMP 5.03356
159 4X3R 686 5.03356
160 5IM3 DTP 5.03356
161 1ZX5 LFR 5.03356
162 2J9C ATP 5.04202
163 4K49 HFQ 5.14706
164 4O4F IHP 5.24194
165 4O4F ATP 5.24194
166 5M45 AMP 5.35714
167 5YK1 ANP 5.36913
168 5G5G FAD 5.66038
169 5EQY 5RA 5.7047
170 1Z2P ACP 5.7047
171 1Z2P I3S 5.7047
172 5C1P DAL DAL 5.7047
173 5C1P ADP 5.7047
174 1GSA ADP 5.7047
175 1PSC EBP 5.7047
176 4CC6 L5Y 5.7047
177 5KBF CMP 5.7047
178 1A99 PUT 5.7047
179 5BNS 4VM 5.7047
180 4OCJ NDG 6.04027
181 1KJ8 GAR 6.04027
182 1KJ8 ATP 6.04027
183 5FI4 5XV 6.04027
184 6C8X BVR 6.06061
185 5CSD ACD 6.28931
186 5MW8 ATP 6.37584
187 2Q7D ANP 6.37584
188 3VSV XYS 6.37584
189 3NJ4 NAD 6.37584
190 2CFC NAD 6.4
191 3BP1 GUN 6.55172
192 3ETH ATP 6.71141
193 2Q7V FAD 6.71141
194 2GOO NDG 6.86275
195 4AZW ATP 7.04698
196 2ZXI FAD 7.04698
197 3VPB ADP 7.0922
198 3VPC ADP 7.0922
199 4LRJ ANP 7.10059
200 1IR2 CAP 7.14286
201 5G6U YJM 7.27969
202 5KJZ PCG 7.33333
203 5COU ATP 7.35294
204 3WVR AMP 7.38255
205 3ICT FAD 7.38255
206 1EHI ADP 7.38255
207 4X3H ARG ILE PRO SER TYR ARG TYR ARG TYR 7.59494
208 1DKU AP2 7.71812
209 6CI9 NAP 7.72201
210 3O5N BR0 8.03571
211 6AC9 ANP 8.05369
212 5C4L 4XR 8.05369
213 4DFU QUE 8.05369
214 5C4L SIS 8.05369
215 1YBH FAD 8.05369
216 1TQP ATP 8.15603
217 5LXT ACP 8.38926
218 3TII ANP 8.38926
219 4R38 RBF 8.57143
220 4O1P ANP 8.72483
221 4PU5 ANP 8.72483
222 3IAA TYD 8.72483
223 3RSC TYD 8.72483
224 1I1N SAH 8.84956
225 1HFE CYS 8.94309
226 4IX4 ADP 9.0604
227 4NZN ANP 9.0604
228 4NZN 2OU 9.0604
229 6C1S EFV 9.0604
230 5FJN FAD 9.39597
231 5FJN BE2 9.39597
232 1MGP PLM 9.39597
233 1VPV PLM 9.39597
234 3ZLR X0B 9.49367
235 4GYI ADP 9.73154
236 2VQD AP2 9.73154
237 2ZL7 FUC GAL NGA 9.73154
238 5TWJ SAM 9.87654
239 2BKK ADP 10.0592
240 2PUL ACP 10.0671
241 4RDL FUC GAL NDG FUC 10.0671
242 4NFE BEN 10.1266
243 1ONI BEZ 10.1449
244 1M0W ANP 10.4027
245 5FS0 5JC 10.4265
246 4CS9 AMP 10.582
247 2WAT COA 10.6557
248 4I94 ANP 10.7383
249 2BMB PMM 10.7383
250 1ZTH ADP 10.8527
251 1ZP9 ATP 10.8527
252 6G34 5ID 11.0738
253 4OUC 5ID 11.0738
254 4YHQ G10 11.1111
255 3RE4 TO1 11.2403
256 4XZ3 ACP 11.4094
257 1N62 FAD 11.4583
258 4Q5H ANP 11.8421
259 4FOU C2E 11.9658
260 5WS9 AMP 12.0805
261 5GZ9 ANP 12.4161
262 4ZOH FAD 12.5
263 1M26 GAL A2G 12.782
264 2V2V V12 12.9151
265 3OCP CMP 12.9496
266 3X01 AMP 13.2316
267 5DMZ ADP 14.094
268 4CYI ATP 14.7651
269 3Q60 ATP 14.7651
270 4B1L FRU 15.1515
271 3UOY FAD 15.4362
272 3UOY NAP 15.4362
273 1VL8 NAP 15.4362
274 4G17 0VN 15.7576
275 2Z49 AMG 16.443
276 2Z48 A2G 16.443
277 4XH0 ADP 16.7785
278 5DZT AMP 16.7785
279 2CSN CKI 16.835
280 4WW7 AMP 17.1123
281 3GD4 FAD 18.7919
282 3GD4 NAD 18.7919
283 5CKW ANP 19.1275
284 1CBK ROI 19.375
285 3TDV GDP 19.4631
286 5AE9 OKO 19.4631
287 6EZ6 C5Z 19.4631
288 4XYM A12 20.4348
289 3ALN ANP 20.4698
290 4WOV 3SM 20.4698
291 3VHE 42Q 20.8054
292 4AG8 AXI 20.8054
293 4ASE AV9 20.8054
294 3PP0 03Q 20.8054
295 3KRL KRL 20.8054
296 5USZ SKE 21.4533
297 5C03 AGS 21.4765
298 3E8N ATP 21.7009
299 3E8N VRA 21.7009
300 4OAV ACP 22.1477
301 6GQM F8H 23.1544
302 4U0I 0LI 23.4921
303 5QIN J2V 23.8255
304 4Y0X ADP 23.8255
305 2PZI AXX 23.8255
306 5MY8 RXZ 24.8322
307 3UIM ANP 25.1678
308 3LXN MI1 25.5034
309 4OH4 ANP 25.5034
310 5LPZ ADP 25.5034
311 4GJ3 0XP 25.5034
312 5NKB 8ZT 25.5034
313 5LPB ADP 25.6757
314 1TMM HHR 25.9494
315 1TMM APC 25.9494
316 4E1Z 0MX 26.1168
317 2QLU ADE 26.5101
318 4CLI 5P8 26.8456
319 4P5Z Q7M 26.8456
320 2Y6O 1N1 27.1478
321 4BTK DTQ 27.1812
322 6ES0 BW8 27.1812
323 4NFN 2KC 27.1812
324 5HES 032 27.5168
325 5U6C 7YS 27.5168
326 4JR7 GNP 27.5168
327 3GNI ATP 27.5168
328 1VJY 460 27.5168
329 5EOB 5QQ 27.8523
330 1JPA ANP 27.8523
331 5OMY 9YE 27.8772
332 4Y93 746 28.1879
333 5K2M ADP 28.3019
334 5T8O 76Z 28.3668
335 3LXK MI1 28.5235
336 6GZD LCI 28.5235
337 4FL3 ANP 28.5235
338 3C1X CKK 28.5235
339 5HCY 60D 28.8591
340 5UIU 8CG 29.1946
341 5DRB 5FJ 29.2096
342 1U59 STU 29.8658
343 5WNL STU 29.8658
344 3SLS ANP 30.2013
345 5JKG 6LF 30.2013
346 4CRL C1I 30.5369
347 4K33 ACP 30.5369
348 5VCV 1N1 31.2081
349 5FBN 5WF 31.3653
350 6BFN DL1 31.5436
351 2PVF ACP 31.5436
352 5UR1 YY9 31.5436
353 3GQI ACP 31.5436
354 3RI1 3RH 31.5436
355 5OKT 9XK 31.8792
356 4KBA 1QM 31.8792
357 5W4W 9WG 31.8792
358 6GIN IR2 32.5503
359 5VC5 96M 32.872
360 3H9R TAK 32.8859
361 5MJA 7O3 33.557
362 5CEO 50D 33.6667
363 4IDT T28 33.8926
364 5Y80 IRE 33.8926
365 2XVD AS6 33.8926
366 4Y8D 49J 33.8926
367 3PLS ANP 33.8926
368 6A1G 9OL 33.8926
369 4YZC STU 34.2282
370 5KO1 6UY 34.2756
371 4UXL 5P8 34.5638
372 4F9C 0SX 34.5638
373 5JFS 6K0 34.5638
374 5AWM ANP 34.8993
375 3GC0 AMP 34.8993
376 5WO4 B7V 35.2349
377 6C7Y ADP 35.2349
378 4NST ADP 35.2349
379 3KMW ATP 35.4244
380 1OPK P16 35.5705
381 3FHR P4O 35.5705
382 4XV1 904 35.5705
383 1Q8Y ADE 35.5705
384 2WQN ADP 35.5705
385 5EFQ ADP 35.5705
386 1Q8Y ADP 35.5705
387 4IJP 1EH 35.5705
388 4Y85 499 35.5705
389 6FYL 3NG 35.5705
390 5Y86 HRM 35.906
391 6F3G CJN 35.906
392 3NW7 LGV 35.906
393 5ZTN CUR 35.906
394 1CM8 ANP 35.906
395 5EKO N17 35.906
396 4CQE CQE 35.906
397 1K3A ACP 36.1204
398 4EUU BX7 36.2416
399 5TO8 7FM 36.5248
400 4UX9 ANP 36.5772
401 4L9I 8PR 36.5772
402 4PNI KQQ 36.5772
403 4E93 GUI 36.5772
404 5LI9 ACP 36.9128
405 2RIO ADP 36.9128
406 5HVJ ANP 36.9128
407 5LI1 ANP 36.9128
408 2X2M X2M 37.2483
409 5JGA 6KC 37.2483
410 2OO8 RAJ 37.2483
411 4EWH T77 37.4545
412 5TA6 79D 37.5839
413 4IZY 1J2 37.5839
414 3FC2 IBI 37.5839
415 1OUK 084 37.9195
416 4LOO SB4 37.9195
417 4BHN BH9 38.255
418 4DC2 ADE 38.255
419 2A19 ANP 38.3803
420 3BZ3 YAM 38.4058
421 5HQ0 LZ9 38.4106
422 6GU6 1QK 38.4106
423 5DBX ANP 38.5906
424 2OFV 242 38.6282
425 6E2O S0L 38.6441
426 4A4X JUP 38.7097
427 4TWP AXI 39.1144
428 3SXS PP2 39.1791
429 1V0O INR 39.5833
430 3SRV S19 39.7112
431 4G31 0WH 39.7993
432 1BYG STU 39.9281
433 5DH3 5BS 39.9329
434 5M06 ADP 39.9329
435 1U5R ATP 40.2685
436 4F4P 0SB 40.293
437 6GWR FEW 40.3175
438 2HK5 1BM 40.604
439 3VRY B43 40.604
440 3ZRM ZRM 40.604
441 4NM5 ADP 40.604
442 3F7Z 34O 40.604
443 2JLD AG1 40.604
444 4ITH RCM 40.8163
445 1O9U ADZ 41.2752
446 5N87 N66 41.6107
447 4X7Q 3YR 41.6107
448 4RFM 3P6 42.1053
449 3ORK AGS 42.2819
450 4M69 ANP 42.6175
451 2R5T ANP 42.953
452 5H2U 1N1 43.4457
453 4OTH DRN 43.6242
454 4L3L 5FI 43.6242
455 6CZ3 FLJ 43.9394
456 3CY2 MB9 43.9597
457 2WU6 DKI 44.2953
458 4N70 2HX 44.2953
459 2F57 23D 44.2953
460 5UPK ANP 44.2953
461 3BU5 ATP 44.2953
462 3EKK GS2 44.2953
463 6CQF F97 44.4444
464 4AT3 LTI 44.4816
465 1IR3 ANP 44.6309
466 4YMJ 4EJ 44.6309
467 4QMN DB8 44.8387
468 1UNH IXM 44.863
469 3O0G 3O0 44.863
470 6C0T EE4 44.9664
471 2JDR L20 44.9664
472 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 44.9664
473 6G33 5ID 44.9664
474 5X8I SQZ 44.9664
475 2H8H H8H 44.9664
476 1Y57 MPZ 44.9664
477 4WNK 453 44.9664
478 3RWP ABQ 45.302
479 3TXO 07U 45.302
480 4UAL 3FV 45.302
481 5LVP ATP 45.6376
482 1ZY5 ANP 45.6376
483 6BXI ANP 45.6376
484 4I6H 1C8 45.6376
485 3PVW QRX 45.6376
486 3MVH WFE 45.6376
487 5UKL SIX 45.6376
488 4YZN 4K5 45.6446
489 4NW6 2NS 45.9732
490 6FYV 3NG 45.9732
491 4USF 6UI 45.9732
492 3G5D 1N1 46.1538
493 2B9J ADP 46.6443
494 2B9I ADP 46.6443
495 2B9H ADP 46.6443
496 2B9F ADP 46.9799
497 4WB6 ATP 46.9799
498 5IH9 6BF 46.9799
499 5EH0 5NW 47.2868
500 1XJD STU 47.3154
501 3TKI S25 47.3154
502 2HY0 306 47.3154
503 4BFM ANP 47.3154
504 4WB7 ATP 47.3154
505 4C2V YJA 47.3684
506 5EYK 5U5 47.4638
507 4CSV STI 47.6364
508 2QCS ANP 47.651
509 6GUE FB8 47.651
510 4CFU 2WC 47.651
511 4BCN T9N 47.651
512 4BCM T7Z 47.651
513 4BCQ TJF 47.651
514 3KN5 ANP 47.651
515 5LMK 6ZK 47.651
516 5LXM ADP 47.7032
517 2GU8 796 47.9866
518 2XMY CDK 47.9866
519 3IDB ANP 47.9866
520 1RE8 BD2 47.9866
521 3DLS ADP 48.3221
522 3FHI ANP 48.3221
523 4H3P ANP 48.3221
524 4H3Q ANP 48.3221
525 4QTB 38Z 48.3221
526 5BVE 4VG 48.3221
527 4C2W ANP 48.3871
528 5ODT ADP 48.4099
529 5G1X ADP 48.4211
530 5L8L ADP 48.4211
531 3TTI KBI 48.6577
532 4WHZ 3NL 48.6577
533 3E7O 35F 48.6577
534 3PTG 932 48.9933
535 3GC8 B45 48.9933
536 2BPM 529 49.3289
537 5DEY 59T 49.4949
538 3V8S 0HD 49.6644
539 2YAB AMP 50
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