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Receptor
PDB id Resolution Class Description Source Keywords
2ZSC 1.3 Å NON-ENZYME: BINDING TAMAVIDIN2, NOVEL AVIDIN-LIKE BIOTIN-BINDING PROTEINS FROM A MUSHROOM PLEUROTUS CORNUCOPIAE BIOTIN BINDING PROTEIN AVIDIN-LIKE STRUCTURE
Ref.: TAMAVIDINS--NOVEL AVIDIN-LIKE BIOTIN-BINDING PROTEI THE TAMOGITAKE MUSHROOM FEBS J. V. 276 1383 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BTN A:301;
B:301;
Valid;
Valid;
none;
none;
submit data
244.311 C10 H16 N2 O3 S C1[C@...
GOL A:1810;
A:1811;
A:1812;
A:1813;
B:1810;
B:1811;
B:1812;
B:1813;
B:3287;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
MG A:501;
B:201;
B:401;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2ZSC 1.3 Å NON-ENZYME: BINDING TAMAVIDIN2, NOVEL AVIDIN-LIKE BIOTIN-BINDING PROTEINS FROM A MUSHROOM PLEUROTUS CORNUCOPIAE BIOTIN BINDING PROTEIN AVIDIN-LIKE STRUCTURE
Ref.: TAMAVIDINS--NOVEL AVIDIN-LIKE BIOTIN-BINDING PROTEI THE TAMOGITAKE MUSHROOM FEBS J. V. 276 1383 2009
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 2ZSC - BTN C10 H16 N2 O3 S C1[C@H]2[C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 2ZSC - BTN C10 H16 N2 O3 S C1[C@H]2[C....
50% Homology Family (115)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 2G5L - FME ASP VAL GLU ALA TRP LEU n/a n/a
2 3WZO - ZOE C16 H27 N3 O5 S C1[C@H]2[C....
3 2RTM - IMI C10 H17 N3 O2 S C1[C@H]2[C....
4 4Y59 Kd = 5.8 uM T21 C14 H8 F3 N O2 c1cc(cc(c1....
5 1NQM - BTN C10 H16 N2 O3 S C1[C@H]2[C....
6 1VWQ - HIS PRO GLN GLY PRO PRO CYS LYS NH2 LEA n/a n/a
7 1NC9 - IMI C10 H17 N3 O2 S C1[C@H]2[C....
8 2RTI - GLL C4 H6 N4 O2 C12C(NC(=O....
9 5B5G Kd = 5.6 uM 6FX C14 H10 N2 O4 COC(=O)c1c....
10 4Y5D Kd = 1.2 uM MT6 C15 H11 N O4 COC(=O)c1c....
11 1SRJ - NAB C17 H12 N2 O3 c1ccc2c(c1....
12 4CPF - LH3 C32 H34 N4 O6 S COC(=O)c1c....
13 1NDJ - BTN C10 H16 N2 O3 S C1[C@H]2[C....
14 2IZL Kd = 1 uM IMI C10 H17 N3 O2 S C1[C@H]2[C....
15 2RTJ - GLL C4 H6 N4 O2 C12C(NC(=O....
16 1SWR Kd = 0.12 uM BTN C10 H16 N2 O3 S C1[C@H]2[C....
17 1SWE - BTN C10 H16 N2 O3 S C1[C@H]2[C....
18 1SRF - MTB C17 H18 N2 O3 CC(C)(C)c1....
19 2RTO - IMI C10 H17 N3 O2 S C1[C@H]2[C....
20 1SWT - BTN C10 H16 N2 O3 S C1[C@H]2[C....
21 1SWP Ka = 100000000 M^-1 BTN C10 H16 N2 O3 S C1[C@H]2[C....
22 1VWG - ACE CYS HIS PRO GLN GLY PRO PRO CYS NH2 n/a n/a
23 2RTF - BTN C10 H16 N2 O3 S C1[C@H]2[C....
24 1VWC - ACE CYS HIS PRO GLN PHE CYS NH2 n/a n/a
25 1STS Ki = 10 uM PHE CYS HIS PRO GLN ASN THR NH2 n/a n/a
26 2IZI - BTN C10 H16 N2 O3 S C1[C@H]2[C....
27 1VWN Kd ~ 1500 nM ACE CYS HIS PRO GLN PHE CYS NH2 n/a n/a
28 2IZF - BTN C10 H16 N2 O3 S C1[C@H]2[C....
29 1SWD - BTN C10 H16 N2 O3 S C1[C@H]2[C....
30 1LCW - SHM C11 H18 N2 O3 S C1[C@H]2[C....
31 1RXK - BNI C16 H20 N4 O4 S c1cc(ccc1N....
32 1SRG Ki = 5 uM MHB C14 H12 N2 O3 Cc1cc(ccc1....
33 1I9H - BNI C16 H20 N4 O4 S c1cc(ccc1N....
34 1VWR - HIS PRO GLN GLY PRO PRO CYS LYS NH2 LEA n/a n/a
35 2IZH - BTN C10 H16 N2 O3 S C1[C@H]2[C....
36 2RTP - IMI C10 H17 N3 O2 S C1[C@H]2[C....
37 1SLD Kd = 270 nM ACE CYS HIS PRO GLN PHE CYS NH2 n/a n/a
38 1KL3 Kd = 1.37 uM ASN TRP SER HIS PRO GLN PHE GLU LYS n/a n/a
39 1DF8 Kd = 0.2 nM BTN C10 H16 N2 O3 S C1[C@H]2[C....
40 3T6F - BTN C10 H16 N2 O3 S C1[C@H]2[C....
41 1VWO - ACE CYS HIS PRO GLN GLY PRO PRO CYS NH2 n/a n/a
42 1VWK - HIS PRO GLN GLY PRO PRO CYS LYS NH2 LEA n/a n/a
43 1SLG Kd = 125 uM PHE SER HIS PRO GLN ASN THR n/a n/a
44 2RTQ - IMI C10 H17 N3 O2 S C1[C@H]2[C....
45 1N43 - BTN C10 H16 N2 O3 S C1[C@H]2[C....
46 3WZN - BTN C10 H16 N2 O3 S C1[C@H]2[C....
47 1VWD - ACE CYS HIS PRO GLN PHE CYS NH2 n/a n/a
48 2Y3F - BTN C10 H16 N2 O3 S C1[C@H]2[C....
49 1VWL Kd = 2.33 uM HIS PRO GLN GLY PRO PRO CYS LYS NH2 LEA n/a n/a
50 1VWA - PHE SER HIS PRO GLN ASN THR n/a n/a
51 2IZG - BTN C10 H16 N2 O3 S C1[C@H]2[C....
52 3MG5 - BTN C10 H16 N2 O3 S C1[C@H]2[C....
53 1SRI Ki = 0.83 uM DMB C15 H14 N2 O3 Cc1cc(cc(c....
54 1KL5 Kd = 1 uM ASN TRP SER HIS PRO GLN PHE GLU LYS n/a n/a
55 1VWH - ACE CYS HIS PRO GLN GLY PRO PRO CYS NH2 n/a n/a
56 1PTS - PHE SER HIS PRO GLN ASN THR n/a n/a
57 1MK5 - BTN C10 H16 N2 O3 S C1[C@H]2[C....
58 1LUQ - BTN C10 H16 N2 O3 S C1[C@H]2[C....
59 1VWB - ACE CYS HIS PRO GLN PHE CYS NH2 n/a n/a
60 2IZK - GLL C4 H6 N4 O2 C12C(NC(=O....
61 1VWE - ACE CYS HIS PRO GLN PHE CYS NH2 n/a n/a
62 2RTN - IMI C10 H17 N3 O2 S C1[C@H]2[C....
63 1MEP - BTN C10 H16 N2 O3 S C1[C@H]2[C....
64 3WYP - BTN C10 H16 N2 O3 S C1[C@H]2[C....
65 2RTL - IMI C10 H17 N3 O2 S C1[C@H]2[C....
66 1N9M - BTN C10 H16 N2 O3 S C1[C@H]2[C....
67 1VWI - HIS PRO GLN GLY PRO PRO CYS LYS NH2 LEA n/a n/a
68 2IZJ - BTN C10 H16 N2 O3 S C1[C@H]2[C....
69 1STR Ki = 17 uM ACE CYS HIS PRO GLN ASN THR NH2 n/a n/a
70 1VWP - ACE CYS HIS PRO GLN GLY PRO PRO CYS NH2 n/a n/a
71 1VWJ - HIS PRO GLN GLY PRO PRO CYS LYS NH2 LEA n/a n/a
72 1LCV - SNR C9 H14 N2 O3 S C1[C@H]2[C....
73 1RSU Kd = 72 uM SER ASN TRP SER HIS PRO GLN PHE GLU LYS n/a n/a
74 2RTH - GLL C4 H6 N4 O2 C12C(NC(=O....
75 5B5F Kd = 5.6 uM 6F3 C14 H12 N2 O4 S CNS(=O)(=O....
76 2F01 Kd ~ 0.1 pM BTN C10 H16 N2 O3 S C1[C@H]2[C....
77 1VWM - ACE CYS HIS PRO GLN PHE CYS NH2 n/a n/a
78 2GH7 Kd ~ 0.1 pM BTN C10 H16 N2 O3 S C1[C@H]2[C....
79 4JNJ - BTN C10 H16 N2 O3 S C1[C@H]2[C....
80 2JGS Kd = 10 fM BTN C10 H16 N2 O3 S C1[C@H]2[C....
81 3SZJ - BTN C10 H16 N2 O3 S C1[C@H]2[C....
82 3T2W Kd = 0.00000145 M BTN C10 H16 N2 O3 S C1[C@H]2[C....
83 3RDQ Kd = 0.49 nM DTB C10 H18 N2 O3 C[C@H]1[C@....
84 3RDO Kd = 0.14 nM BTN C10 H16 N2 O3 S C1[C@H]2[C....
85 3RDM Kd = 0.14 nM BTN C10 H16 N2 O3 S C1[C@H]2[C....
86 2OF8 - BNI C16 H20 N4 O4 S c1cc(ccc1N....
87 2FHL - BNI C16 H20 N4 O4 S c1cc(ccc1N....
88 2OFB - BNI C16 H20 N4 O4 S c1cc(ccc1N....
89 3X00 Kd = 0.83 nM ZOF ZOF EDN n/a n/a
90 2A5C Kd = 24 uM 8DA C10 H15 N5 O4 C1[C@H]([C....
91 3VGW Ka = 200000 M^-1 NVZ C12 H18 N2 O4 S CC(=O)N1[C....
92 1IJ8 - BNI C16 H20 N4 O4 S c1cc(ccc1N....
93 3VHI Ka = 2300000 M^-1 VHI C18 H22 N2 O5 S c1ccc(cc1)....
94 2A8G Kd = 205 uM GNG C10 H13 N5 O4 c1nc2c(n1[....
95 4I60 Kd = 1.87 uM B1R C20 H16 N2 O2 Ru S C1[C@H]2[C....
96 5IRW - D9P C26 H26 N2 O2 C[C@H]1[C@....
97 5F2B - 9RU C31 H41 Cl2 N5 O2 Ru S Cc1cc(c(c(....
98 4OKA - 5IR C18 H26 Ir N5 O4 S2 c1cc(ccc1N....
99 6AUL - BTN C10 H16 N2 O3 S C1[C@H]2[C....
100 4GJV - 0OD C21 H32 Cl3 N3 O2 Rh S CC12=C3([R....
101 6ESU Ki = 249.3 mM 6IR C18 H27 N5 O4 S2 c1cc(ccc1N....
102 4GJS - 0OD C21 H32 Cl3 N3 O2 Rh S CC12=C3([R....
103 2WPU Kd < 60 nM KYT C24 H39 Cl N5 O2 Ru S CC1=[CH]2C....
104 3PK2 - 4IR C28 H45 Cl Ir N5 O4 S2 C[CH]12[CH....
105 6ESS - 4IR C28 H45 Cl Ir N5 O4 S2 C[CH]12[CH....
106 2ZSC - BTN C10 H16 N2 O3 S C1[C@H]2[C....
107 3EW2 - BTN C10 H16 N2 O3 S C1[C@H]2[C....
108 5N99 Kd = 61.3 uM ASN GLN DPR TRP GLN n/a n/a
109 4GGZ Kd = 0.066 nM BTN C10 H16 N2 O3 S C1[C@H]2[C....
110 2UYW - BTN C10 H16 N2 O3 S C1[C@H]2[C....
111 2UZ2 - BTN C10 H16 N2 O3 S C1[C@H]2[C....
112 1SWG Kd = 43.9 nM BTN C10 H16 N2 O3 S C1[C@H]2[C....
113 4GD9 - BTN C10 H16 N2 O3 S C1[C@H]2[C....
114 4BCS Kd = 103 nM BTN C10 H16 N2 O3 S C1[C@H]2[C....
115 4EKV Kd = 0.00000145 M BTN C10 H16 N2 O3 S C1[C@H]2[C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: BTN; Similar ligands found: 17
No: Ligand ECFP6 Tc MDL keys Tc
1 BTQ 1 1
2 BTN 1 1
3 SHM 0.884615 1
4 SNR 0.807692 1
5 BH7 0.734375 0.921569
6 IMI 0.644068 0.803922
7 BTI 0.62069 0.914894
8 B1R 0.6 0.632353
9 BYT 0.581081 0.87037
10 BNI 0.554054 0.656716
11 41M 0.554054 0.830189
12 B9P 0.5 0.796296
13 ZOF 0.493333 0.833333
14 LUV 0.476744 0.745763
15 NVZ 0.457143 0.75
16 LH3 0.455556 0.666667
17 BSO 0.454545 0.79661
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2ZSC; Ligand: BTN; Similar sites found with APoc: 160
This union binding pocket(no: 1) in the query (biounit: 2zsc.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 2GOO NDG None
2 2P7Q GG6 None
3 5IXH OTP None
4 3BY8 MLT None
5 3T50 FMN None
6 1P0Z FLC None
7 1OGX EQU 0.763359
8 1SNY NAP 1.41844
9 6GG9 FMN 1.41844
10 5L4S 6KX 1.57233
11 5L4S NAP 1.57233
12 1QY1 PRZ 2.12766
13 6EOZ 58K 2.12766
14 6EOZ AKG 2.12766
15 5A96 GTP 2.12766
16 3GM5 CIT 2.12766
17 3G5S FAD 2.12766
18 3RGA ILD 2.12766
19 1RP0 AHZ 2.12766
20 3RGA LSB 2.12766
21 5TFZ 7BC 2.12766
22 1QIN GIP 2.83688
23 1V7R CIT 2.83688
24 4J7U NAP 2.83688
25 4J7U YTZ 2.83688
26 1Z6Z NAP 2.83688
27 5EVY SAL 2.83688
28 2A1L PCW 2.83688
29 4CUB GAL NAG 2.83688
30 4R38 RBF 2.85714
31 1KGI T4A 3.14961
32 5VKI THR NGA GAL NAG 3.5461
33 5O9W AKG 3.5461
34 4WOE 3S5 3.5461
35 2ABS ACP 3.5461
36 6MPT C30 3.5461
37 1UNB AKG 3.5461
38 3VPB ADP 3.5461
39 1UNB PN1 3.5461
40 4AF5 CIT 4.25532
41 4CCK OGA 4.25532
42 2IID FAD 4.25532
43 2IID PHE 4.25532
44 2OBF SAH 4.25532
45 2OBF F83 4.25532
46 4CCN OGA 4.25532
47 4Y3O OGA 4.25532
48 3P7N FMN 4.25532
49 5EO8 TFU 4.25532
50 4CCO OGA 4.25532
51 1VA6 P2S 4.25532
52 4RYV ZEA 4.25532
53 5GP0 GPP 4.25532
54 5XWV 8H6 4.25532
55 1V1A KDG 4.25532
56 4BVM VCA 4.51128
57 4BVM PLM 4.51128
58 4N14 WR7 4.96454
59 3HZL 6PC 4.96454
60 5EOB 5QQ 4.96454
61 5KD6 LBU 4.96454
62 5KD6 6C7 4.96454
63 4GN8 ASO 4.96454
64 3FPF TNA 4.96454
65 4L3L 5FI 4.96454
66 3FPF MTA 4.96454
67 4AZW ATP 4.96454
68 1V8B NAD 4.96454
69 4M26 AKG 4.96454
70 2PVN P63 4.96454
71 4J25 OGA 5.67376
72 2JIG PD2 5.67376
73 3KV4 OGA 5.67376
74 1QD1 FON 5.67376
75 5EFW FMN 5.67376
76 1NOW IFG 5.67376
77 5WQP NCA 5.67376
78 1GZ6 NAI 5.67376
79 5XSJ XYP 5.67376
80 4D42 NAP 5.67376
81 4D42 W0I 5.67376
82 3FW4 CAQ 5.67376
83 6BFH KAN 5.67376
84 2GJ5 VD3 6.38298
85 2HZQ STR 6.38298
86 3RI1 3RH 6.38298
87 5M67 NAD 6.38298
88 5TQZ GLC 6.38298
89 5M67 3D1 6.38298
90 1U3U NAD 6.38298
91 1U3U BNF 6.38298
92 5M67 ADE 6.38298
93 2F2G HMH 6.38298
94 4XCB AKG 6.38298
95 6BU0 IHP 6.87023
96 2DUR MAN MAN 7.0922
97 4CNO 9PY 7.0922
98 5ML3 DL3 7.80142
99 1E8G FAD 7.80142
100 2RDQ AKG 7.80142
101 3KV5 OGA 7.80142
102 1J6W MET 7.80142
103 5DKK FMN 7.80142
104 5IXG OTP 8.51064
105 4WES HCA 8.51064
106 3THR C2F 8.51064
107 1N9L FMN 9.17431
108 5JSP DQY 9.21986
109 5BU3 4W9 9.21986
110 4L2I NAD 9.21986
111 4L2I FAD 9.21986
112 3JUC PCA 9.21986
113 1REQ DCA 9.21986
114 1VYF OLA 9.62963
115 1O4T OXL 9.77444
116 1RP7 TZD 9.92908
117 3AYI FAD 9.92908
118 1JBW ACQ 9.92908
119 4GCZ FMN 9.92908
120 5AIG VPR 10.4
121 3N9O OGA 10.6383
122 3N9P OGA 10.6383
123 4J36 FAD 10.6383
124 3N9Q OGA 10.6383
125 4HIA FMN 10.7955
126 5TBM 79A 11.3043
127 5JWP AKG 11.3475
128 1QH8 HCA 11.3475
129 3P3N AKG 11.3475
130 1H2M OGA 11.3475
131 2XUM OGA 11.3475
132 2Y0I AKG 11.3475
133 5C5T AKG 12.0567
134 4EU7 COA 12.0567
135 4EU7 CIT 12.0567
136 5HWK BEZ 12.766
137 5BVB DOG 12.8788
138 4WO4 JLS 13
139 3HUJ AGH 13.1313
140 1ZB6 GST 13.4752
141 1ZB6 DIN 13.4752
142 4FFG LBS 13.4752
143 4R78 AMP 13.4752
144 3G08 FEE 14.1414
145 3QUZ QUV 14.1414
146 3RUG DB6 14.1414
147 4RLT FSE 14.1844
148 1IND EOT 14.1844
149 4YZ5 SLT 14.1844
150 4IJP 1EH 14.1844
151 3RWP ABQ 14.8936
152 2QL9 CIT 15.4639
153 5A1T OXM 15.6028
154 3X27 TRP 15.6028
155 2BMR 3NT 15.6028
156 4R3U 3KK 16.3121
157 4R3U 3HC 16.3121
158 5UIU 8CG 18.4397
159 5HV0 AKG 21.9858
160 3ECN IBM 22.695
Pocket No.: 2; Query (leader) PDB : 2ZSC; Ligand: BTN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2zsc.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2ZSC; Ligand: BTN; Similar sites found with APoc: 55
This union binding pocket(no: 3) in the query (biounit: 2zsc.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 1KW6 BPY 1.41844
2 6GNO XDI 1.48148
3 1SJD NPG 2.12766
4 3AVR OGA 2.83688
5 3O2K DST 2.83688
6 5XJD 87L 2.83688
7 5OO5 UUA 3.22581
8 2GU8 796 3.5461
9 5WQJ 7N3 3.5461
10 6FXR AKG 3.5461
11 5SVV FMN 3.64964
12 2XK9 XK9 4.25532
13 4OIV XX9 4.25532
14 2E9L PLM 4.25532
15 2E9L BGC 4.25532
16 1Q19 SSC 4.25532
17 4WUJ FMN 4.25532
18 4OCJ NDG 4.25532
19 1EWJ BLM 4.7619
20 3UXL CFI 4.96454
21 1EWF PC1 4.96454
22 5I0U DCY 4.96454
23 3MTX PGT 4.96454
24 5NXX 3Q7 4.96454
25 5N9T 8QQ 4.96454
26 5YF9 NIO 5.67376
27 6F6D AKG 5.67376
28 2AK3 AMP 5.67376
29 5WYZ 7VF 6.38298
30 5D6T NGA 6.38298
31 5I60 67W 6.38298
32 1OX5 1PR 6.38298
33 3DAK ANP 6.38298
34 4BXF AKG 6.38298
35 4ZJS 4P0 7.0922
36 4D06 NAR 7.0922
37 4H6B 10X 7.0922
38 3B1Q NOS 7.0922
39 1I7M PUT 7.46269
40 5Y4K AKR 7.80142
41 4B1M FRU FRU 8.51064
42 5F33 PGH 8.51064
43 3DU4 KAP 8.51064
44 5INJ 6C7 9.92908
45 4J36 1HR 10.6383
46 5DZ2 212 10.6383
47 5Y6Q FAD 11.3475
48 4AVV CD 11.3475
49 4AVV GHE 11.3475
50 1U6R IOM 11.3475
51 3PVW QRX 12.0567
52 5UKL SIX 12.0567
53 2P1C GG3 12.766
54 5Y02 HBX 14.9533
55 4C2V YJA 20.4545
Pocket No.: 4; Query (leader) PDB : 2ZSC; Ligand: BTN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2zsc.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
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