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Receptor
PDB id Resolution Class Description Source Keywords
2ZIF 2.4 Å EC: 7.-.-.- CRYSTAL STRUCTURE OF TTHA0409, PUTATIVE DNA MODIFICATION MET FROM THERMUS THERMOPHILUS HB8- COMPLEXED WITH S-ADENOSYL-L- THERMUS THERMOPHILUS MODIFICATION METHYLASE METHYLTRANSFERASE S-ADENOSYLMETHIONTHERMUS THERMOPHILUS STRUCTURAL GENOMICS NPPSFA NATIONALON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES RIKEN STRUCTGENOMICS/PROTEOMICS INITIATIVE RSGI TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF A PUTATIVE DNA METHYLASE TTHA0 THERMUS THERMOPHILUS HB8 PROTEINS V. 73 259 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAM A:298;
B:298;
Valid;
Valid;
none;
none;
Kd = 43 uM
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2ZIF 2.4 Å EC: 7.-.-.- CRYSTAL STRUCTURE OF TTHA0409, PUTATIVE DNA MODIFICATION MET FROM THERMUS THERMOPHILUS HB8- COMPLEXED WITH S-ADENOSYL-L- THERMUS THERMOPHILUS MODIFICATION METHYLASE METHYLTRANSFERASE S-ADENOSYLMETHIONTHERMUS THERMOPHILUS STRUCTURAL GENOMICS NPPSFA NATIONALON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES RIKEN STRUCTGENOMICS/PROTEOMICS INITIATIVE RSGI TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF A PUTATIVE DNA METHYLASE TTHA0 THERMUS THERMOPHILUS HB8 PROTEINS V. 73 259 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 293 families.
1 2ZIF Kd = 43 uM SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 250 families.
1 2ZIF Kd = 43 uM SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 204 families.
1 2ZIF Kd = 43 uM SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2ZIF; Ligand: SAM; Similar sites found with APoc: 704
This union binding pocket(no: 1) in the query (biounit: 2zif.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 5C2N NAG None
2 1ZK7 FAD 1.3468
3 5X68 FAD 1.3468
4 3U31 NAD 1.37931
5 4J7U YTZ 1.38889
6 4J7U NAP 1.38889
7 4NBU NAI 1.6
8 4YAC NAI 1.6835
9 3ICT FAD 1.6835
10 3ICS FAD 1.6835
11 1WD4 AHR 1.6835
12 3ICR FAD 1.6835
13 5EB4 FAD 1.6835
14 5N0J FAD 1.6835
15 5XLX SAH 1.77305
16 5T2U NAP 2.01613
17 4DCM SAM 2.0202
18 3G2O SAM 2.0202
19 3GF4 UPG 2.0202
20 3GF4 FAD 2.0202
21 5XNC MTA 2.0202
22 6GAS FAD 2.0202
23 2CDU FAD 2.0202
24 1WVG APR 2.0202
25 3LZW NAP 2.0202
26 3LZW FAD 2.0202
27 4MOP 2H5 2.0202
28 5XWV NDP 2.0202
29 1REO FAD 2.0202
30 5XWV 8H6 2.0202
31 3NTD FAD 2.0202
32 2QA1 FAD 2.0202
33 5TS5 FAD 2.0202
34 3IHG FAD 2.0202
35 4IV9 FAD 2.0202
36 3MCT SAH 2.0202
37 1KYZ SAH 2.0202
38 1KYZ FER 2.0202
39 3NTA FAD 2.0202
40 4RSL FAD 2.0202
41 3NT6 FAD 2.0202
42 5DNK SAH 2.0202
43 3MAG SAH 2.0202
44 5GWX SAR 2.11268
45 5GWX SAM 2.11268
46 4ITU NAI 2.23048
47 4ITU 1HS 2.23048
48 5DM1 5D7 2.24719
49 5DM1 SAH 2.24719
50 5DLY 5D7 2.25564
51 5DLY SAH 2.25564
52 2DTX BMA 2.27273
53 2ART LPA AMP 2.29008
54 3A28 NAD 2.32558
55 2P41 SAH 2.3569
56 1BZL FAD 2.3569
57 2EG5 SAH 2.3569
58 4RPL 3UC 2.3569
59 4RPL FAD 2.3569
60 6ECT SAM 2.3569
61 1BZL GCG 2.3569
62 2RGO FAD 2.3569
63 4E70 N7I 2.3569
64 1RPN NDP 2.3569
65 2EFJ SAH 2.3569
66 2IVD FAD 2.3569
67 3SSO SAH 2.3569
68 1RJD SAM 2.3569
69 1PS9 FAD 2.3569
70 2IID PHE 2.3569
71 2IID FAD 2.3569
72 1H82 GZZ 2.3569
73 3LXD FAD 2.3569
74 1H82 FAD 2.3569
75 6AIN FAD 2.3569
76 5J60 FAD 2.3569
77 2AWN ADP 2.3569
78 1KOL NAD 2.3569
79 2WET FAD 2.3569
80 4FN4 NAD 2.3622
81 6B92 SAH 2.38095
82 2VDV SAM 2.43902
83 3GU3 SAH 2.46479
84 5KVA SAM 2.51799
85 3EVG SAH 2.54545
86 3A4T SFG 2.55474
87 4X7Y SAH 2.55474
88 2F6U CIT 2.5641
89 2UYQ SAM 2.58065
90 2JBH 5GP 2.66667
91 3FPF TNA 2.6936
92 3FPF MTA 2.6936
93 6ECW SAH 2.6936
94 3L9W GSH 2.6936
95 3L9W AMP 2.6936
96 1GET FAD 2.6936
97 1GET NAP 2.6936
98 6IS0 SAH 2.6936
99 6DEN TP9 2.6936
100 6DEN FAD 2.6936
101 6DEN G8A 2.6936
102 5TWB FAD 2.6936
103 6ECU SAH 2.6936
104 2C5A NAD 2.6936
105 2C5A GDC 2.6936
106 4NTD FAD 2.6936
107 3LST SAH 2.6936
108 4TM3 FAD 2.6936
109 5JAQ NAI 2.6936
110 3CTY FAD 2.6936
111 2Q7V FAD 2.6936
112 4EUE NAI 2.6936
113 1RSG FAD 2.6936
114 5KOX RFP 2.6936
115 5KOX FAD 2.6936
116 1SB8 NAD 2.6936
117 1SB8 UD2 2.6936
118 3GMB FAD 2.6936
119 3AKI AH8 2.6936
120 3T31 DCQ 2.6936
121 3T31 FAD 2.6936
122 5HXI FAD 2.6936
123 5X30 HCS 2.6936
124 4NTC FAD 2.6936
125 1Q0S SAH 2.7027
126 5FTW SAH 2.73438
127 1XTP SAI 2.75591
128 4YAG NAI 2.76817
129 2PK3 A2R 2.80374
130 1NJR XYL 2.8169
131 3EWP APR 2.82486
132 1YC5 NCA 2.84553
133 3ZV6 4HB 2.84698
134 3ZV6 NAD 2.84698
135 1LSS NAD 2.85714
136 1XG5 NAP 2.86738
137 2B4Q NAP 2.89855
138 4YMH SAH 2.91667
139 5FA5 MTA 2.92308
140 4HXY NDP 2.96804
141 4GQB 0XU 2.98273
142 2VZ0 NAP 2.98507
143 2VZ0 D64 2.98507
144 5CUQ NSC 2.99625
145 3RFV 15L 2.99625
146 3RFV NAI 2.99625
147 3CBG SAH 3.01724
148 2O07 MTA 3.0303
149 2O07 SPD 3.0303
150 4YUW S4M 3.0303
151 4YUW 4JU 3.0303
152 2Q28 ADP 3.0303
153 1V59 FAD 3.0303
154 2HQM FAD 3.0303
155 1FP1 SAH 3.0303
156 5FUB SAH 3.0303
157 3S5W FAD 3.0303
158 3P9C SAH 3.0303
159 2YY7 NAD 3.0303
160 6F7L FAD 3.0303
161 1NAA ABL 3.0303
162 3WMX NAD 3.0303
163 1NAA 6FA 3.0303
164 3GDN HBX 3.0303
165 3GDN FAD 3.0303
166 3QJ4 FAD 3.0303
167 1YY5 FAD 3.0303
168 1V59 NAD 3.0303
169 1R6D NAD 3.0303
170 3K7M FAD 3.0303
171 5TUF FAD 3.0303
172 3RKR NAP 3.05344
173 3O7W SAM 3.06122
174 1JQD SAH 3.08219
175 2AOT SAH 3.08219
176 1JQD HSM 3.08219
177 2PS1 ORO 3.09735
178 4X60 SFG 3.10078
179 4X60 3XV 3.10078
180 3BMQ NAP 3.125
181 3FRH SAH 3.16206
182 2CFC NAD 3.2
183 3U4C NDP 3.20285
184 3SJU NDP 3.22581
185 2WA2 SAM 3.26087
186 1EDO NAP 3.27869
187 3FUU ADN 3.32103
188 1BC5 SAH 3.34572
189 2HNK SAH 3.34728
190 1DL5 SAH 3.367
191 3M6W SAM 3.367
192 6D6Y SAH 3.367
193 6FDF SAH 3.367
194 5ERG SAM 3.367
195 3C6K SPD 3.367
196 3C6K MTA 3.367
197 5E9W SAH 3.367
198 2WPF FAD 3.367
199 2WPF WPF 3.367
200 2RAB NAD 3.367
201 2RAB FAD 3.367
202 3HDY GDU 3.367
203 3HDY FDA 3.367
204 3HDY FAD 3.367
205 1ELI PYC 3.367
206 4JDR FAD 3.367
207 6C8R EQV 3.367
208 3TKY SAH 3.367
209 5Z75 NAD 3.367
210 2R4J FAD 3.367
211 2R4J 13P 3.367
212 4K5S PM0 3.367
213 4K5S FAD 3.367
214 2Z3Y F2N 3.367
215 5EEH P9P 3.367
216 5EEH SAH 3.367
217 5BJX NAD 3.367
218 5BJX UDP 3.367
219 6BWL NAD 3.367
220 2JB2 PHE 3.367
221 2JB2 FAD 3.367
222 4FWE FAD 3.367
223 2FR1 NDP 3.367
224 6C8R SAH 3.367
225 5O4J SAH 3.367
226 5O4J 9KH 3.367
227 4USR FAD 3.367
228 5MBX FAD 3.367
229 5MBX SP5 3.367
230 2YYY NAP 3.367
231 1D1T NAD 3.367
232 4EIP FAD 3.367
233 2GDZ NAD 3.37079
234 1TL2 NDG 3.38983
235 1JG3 ADN 3.40426
236 1XCL SAH 3.40426
237 4OBW SAM 3.50195
238 5N5D SAM 3.53982
239 3GCZ SAM 3.5461
240 4ZCC FAD 3.57143
241 4ZCC NAI 3.57143
242 1BDB NAD 3.61011
243 5W7M SAH 3.7037
244 3X0D SAH 3.7037
245 2C31 TZD 3.7037
246 2C31 ADP 3.7037
247 5MPT SAH 3.7037
248 5X62 SAH 3.7037
249 6C5B SAH 3.7037
250 3FPZ AHZ 3.7037
251 1Y8Q ATP 3.7037
252 2GV8 FAD 3.7037
253 5ZYN FAD 3.7037
254 1VQW FAD 3.7037
255 2GVC FAD 3.7037
256 2BRY FAD 3.7037
257 5FWA J7C 3.7037
258 3V1U NAD 3.7037
259 4MIG G3F 3.7037
260 2PX8 SAH 3.71747
261 1UAY ADN 3.71901
262 5ULP KB1 3.73134
263 4QTU SAM 3.84615
264 5YJI 8WO 3.87324
265 5YJI SAH 3.87324
266 1P1C SAH 4.0201
267 1MO9 FAD 4.0404
268 1ORR NAD 4.0404
269 1MO9 KPC 4.0404
270 1FP2 SAH 4.0404
271 2C7G FAD 4.0404
272 2C7G ODP 4.0404
273 1XDS SAM 4.0404
274 5T67 JHZ 4.0404
275 1QZZ SAM 4.0404
276 1FP2 HMO 4.0404
277 4HA6 FAD 4.0404
278 5W7R 9Z7 4.0404
279 4GUS FAD 4.0404
280 5W7R SAH 4.0404
281 4GUT FAD 4.0404
282 3ABI NAD 4.0404
283 3GEG NAD 4.04858
284 1IM8 SAI 4.09836
285 4XUC 43G 4.12844
286 4XUC SAM 4.12844
287 3MQ2 SAH 4.12844
288 2XYQ SAH 4.13793
289 5E1M SAH 4.14938
290 5E1M PRO PRO LYS ARG ILE ALA 4.14938
291 4L2I FAD 4.18251
292 1U7T TDT 4.21456
293 5YJF 8WO 4.22535
294 5YJF SAH 4.22535
295 2CUL FAD 4.31034
296 1DJL NAP 4.34783
297 6EQS BV8 4.36364
298 2PWY SAH 4.3771
299 4PIO SAH 4.3771
300 4PIO AVI 4.3771
301 5J5Z FAD 4.3771
302 2F5Z FAD 4.3771
303 3GWZ SAH 4.3771
304 3RNM FAD 4.3771
305 3I53 SAH 4.3771
306 5G3U FDA 4.3771
307 4B63 FAD 4.3771
308 4B63 NAP 4.3771
309 4B63 ORN 4.3771
310 6GAR FAD 4.3771
311 3GXO SAH 4.3771
312 5G3U ITW 4.3771
313 2ZWA SAH 4.3771
314 3ZNN FAD 4.3771
315 3ZNN 4WL 4.3771
316 3X0V FAD 4.3771
317 3WGT QSC 4.3771
318 4Z24 FAD 4.3771
319 3WGT FAD 4.3771
320 5ZBC FAD 4.3771
321 2HXW FLC 4.3771
322 1JQ3 AAT 4.39189
323 3RIY NAD 4.3956
324 1I1N SAH 4.42478
325 3AD8 NAD 4.4335
326 1EJ0 SAM 4.44444
327 1PNO NAP 4.44444
328 1VL8 NAP 4.49438
329 2DPM SAM 4.57746
330 2WK1 SAH 4.60993
331 1E6E FAD 4.6875
332 1MXH DHF 4.71014
333 5MW4 5JU 4.7138
334 3QOX SAH 4.7138
335 3LAD FAD 4.7138
336 1ZGA SAH 4.7138
337 1PN0 FAD 4.7138
338 1PN0 IPH 4.7138
339 3UOY FAD 4.7138
340 3UOY NAP 4.7138
341 1COY FAD 4.7138
342 5GSN MMZ 4.7138
343 5GSN NAP 4.7138
344 5GSN FAD 4.7138
345 4A6D SAM 4.7138
346 4REP FAD 4.7138
347 5NA1 FAD 4.7138
348 1RYI FAD 4.7138
349 2JC9 ADN 4.7138
350 1RYI GOA 4.7138
351 1XHL NDP 4.7138
352 4JNA FAD 4.7138
353 2Q46 NAP 4.74308
354 4IWN GEK 4.80349
355 4URF NAD 4.83871
356 1R18 SAH 4.84582
357 1T57 FMN 4.85437
358 2HMT NAI 4.86111
359 5K7U SAM 4.88889
360 1D4O NAP 4.8913
361 1WG8 SAM 4.91228
362 6DUB SAH 4.95496
363 1E3W NAD 4.98084
364 1E6W NAD 5
365 3LN9 FLC 5.03597
366 3DXY SAM 5.04587
367 1N2X SAM 5.05051
368 5WKC FAD 5.05051
369 5ICE SAH 5.05051
370 5ICE 2H4 5.05051
371 1T9D P25 5.05051
372 1T9D PYD 5.05051
373 1T9D 1MM 5.05051
374 1T9D FAD 5.05051
375 5VN0 FAD 5.05051
376 2JHP SAH 5.05051
377 5VN0 NAI 5.05051
378 4USQ FAD 5.05051
379 1QO8 FAD 5.05051
380 4BJZ P3A 5.05051
381 4BJZ FAD 5.05051
382 1LVL FAD 5.05051
383 3UCL FAD 5.05051
384 3UCL CYH 5.05051
385 3UCL NAP 5.05051
386 1LVL NAD 5.05051
387 6ER9 NAP 5.05051
388 6ER9 FAD 5.05051
389 4X9M FAD 5.05051
390 3CGB FAD 5.05051
391 4CNK FAD 5.05051
392 5MZI FAD 5.05051
393 5MZI FYK 5.05051
394 1KNR FAD 5.05051
395 5DF1 NAP 5.05051
396 5DF1 58X 5.05051
397 2DKN NAI 5.09804
398 5NMX NAP 5.17647
399 5NMX FAD 5.17647
400 5IL1 SAM 5.18868
401 5JGL SAM 5.19031
402 3G89 SAM 5.22088
403 1NV8 MEQ 5.28169
404 1NV8 SAM 5.28169
405 2I7C AAT 5.30035
406 2A14 SAH 5.32319
407 1QAN SAH 5.32787
408 2AE2 PTO 5.38462
409 2AE2 NAP 5.38462
410 1SQF SAM 5.38721
411 3TKA SAM 5.38721
412 2PT9 2MH 5.38721
413 4LWP SAH 5.38721
414 3A4V PYR 5.38721
415 3A4V NAD 5.38721
416 3CGD FAD 5.38721
417 3CGD COA 5.38721
418 2XVE FAD 5.38721
419 3CGD NAD 5.38721
420 3NYC FAD 5.38721
421 3NYC IAR 5.38721
422 2XVF FAD 5.38721
423 2PT9 S4M 5.38721
424 3BXO SAM 5.43933
425 3A27 SAM 5.51471
426 3AXB FAD 5.58036
427 3AXB PRO 5.58036
428 5BW4 SAM 5.61798
429 2EWM NAD 5.62249
430 3NUG NAD 5.66802
431 1O97 FAD 5.68182
432 1Z3C SA8 5.72391
433 3SQP FAD 5.72391
434 3LKZ SFG 5.72391
435 1RKX NAD 5.72391
436 4MO2 FDA 5.72391
437 1GPE FAD 5.72391
438 4MO2 FAD 5.72391
439 2VVM FAD 5.72391
440 2VVL FAD 5.72391
441 2NPX FAD 5.72391
442 2NPX NAD 5.72391
443 1OC2 NAD 5.72391
444 1OC2 TDX 5.72391
445 2Y6Q FAD 5.72391
446 2Y6Q I7T 5.72391
447 5EJ2 NAD 5.72391
448 4DSG UDP 5.72391
449 4DSG FAD 5.72391
450 4GKV NAD 5.72391
451 5K0A FAD 5.72391
452 1PR9 NAP 5.7377
453 3D3W NAP 5.7377
454 5GWT SIN 5.7554
455 5GWT NAD 5.7554
456 2BZG SAH 6.03448
457 3LU1 NAD 6.04396
458 2ZFU SAH 6.04651
459 6ARJ BW4 6.06061
460 6ARJ SAH 6.06061
461 3VSE SAH 6.06061
462 5HJM MTA 6.06061
463 3ELW SAM 6.06061
464 3ELW GP3 6.06061
465 3VYW SAM 6.06061
466 1F3L SAH 6.06061
467 5DWQ SFG 6.06061
468 5DX0 SFG 6.06061
469 5JCA FAD 6.06061
470 4D5G FAD 6.06061
471 4D5G TPP 6.06061
472 4YRY NAD 6.06061
473 4YRY FAD 6.06061
474 5JCA NDP 6.06061
475 1X87 NAD 6.06061
476 5Y77 FAD 6.06061
477 2PZM UDP 6.06061
478 2PZM NAD 6.06061
479 3EVF SAH 6.13718
480 3EVF GTA 6.13718
481 5OJI NAP 6.15385
482 5OJI ISN 6.15385
483 1KPG SAH 6.27178
484 3CH6 311 6.29371
485 3CH6 NAP 6.29371
486 3C3Y SAH 6.32911
487 5KOK R9T 6.39731
488 5KOK S9T 6.39731
489 4N49 SAM 6.39731
490 5KOK SAH 6.39731
491 1U2Z SAH 6.39731
492 5WS9 AMP 6.39731
493 1YQZ FAD 6.39731
494 4M52 FAD 6.39731
495 4M52 M52 6.39731
496 2A8X FAD 6.39731
497 4C3Y ANB 6.39731
498 4TQG NDP 6.39731
499 4C3Y FAD 6.39731
500 1W8D NAP 6.39731
501 2Q1W NAD 6.39731
502 1M2K APR 6.4257
503 1Q9I FAD 6.47986
504 1Q9I TEO 6.47986
505 1L1E SAH 6.62021
506 1GEG NAD 6.64062
507 2WSB NAD 6.69291
508 4M37 SAH 6.73401
509 2EJU SAH 6.73401
510 4M38 SAH 6.73401
511 4AZW SAM 6.73401
512 5U8U FAD 6.73401
513 4PNE SAH 6.73401
514 4OPC FDA 6.73401
515 4OPC PGT 6.73401
516 4Y9D NAI 6.73401
517 4BV6 FAD 6.73401
518 1UDB UFG 6.73401
519 1UDB NAD 6.73401
520 6FHO FAD 6.73401
521 1GPM AMP 6.73401
522 5N1Q COM 6.89655
523 6CI9 NAP 6.94981
524 1TPY SAH 6.96864
525 1KPH SAH 6.96864
526 2PXX SAH 6.97674
527 2XVM SAH 7.03518
528 4FZV SAM 7.07071
529 5K4W NAI 7.07071
530 5K4W THR 7.07071
531 1E5Q NDP 7.07071
532 4AP3 NAP 7.07071
533 4AP3 FAD 7.07071
534 3NKS FAD 7.07071
535 5TTJ FAD 7.07071
536 3GRU AMP 7.11864
537 4FC7 COA 7.22022
538 4FC7 NAP 7.22022
539 3BGD SAH 7.30769
540 3BGD PM6 7.30769
541 4R6W PC 7.36434
542 4R6W SAH 7.36434
543 4C4A SAH 7.40741
544 5WP4 SAH 7.40741
545 5WP5 SAH 7.40741
546 4D7E FAD 7.40741
547 6F97 FAD 7.40741
548 5EZ7 FAD 7.40741
549 4D04 FAD 7.40741
550 4D04 NAP 7.40741
551 2YG3 FAD 7.40741
552 1EK6 UPG 7.40741
553 1EK6 NAI 7.40741
554 1S7G NAD 7.50988
555 3KIF GDL 7.54717
556 2BES RES 7.55814
557 1OAA OAA 7.72201
558 2YX1 SFG 7.74411
559 5THY SAH 7.74411
560 5THZ SAH 7.74411
561 3VC1 GST 7.74411
562 3VC1 SAH 7.74411
563 5GM1 SAH 7.74411
564 1GTE FAD 7.74411
565 3VZS NAP 7.7821
566 3VZS CAA 7.7821
567 2BD0 NAP 7.78689
568 3LCV SAM 7.82918
569 5ODQ FAD 7.85714
570 1IY8 NAD 7.86517
571 1ZQ9 SAM 8.07018
572 3PT9 SAH 8.08081
573 4Y30 49L 8.08081
574 4KRI SAH 8.08081
575 1FEC FAD 8.08081
576 4RVG TYD 8.08081
577 4RVG SAM 8.08081
578 5BRT CH9 8.08081
579 5BRT FAD 8.08081
580 6GKV SAH 8.08081
581 1I2B USQ 8.08081
582 1I2B UPG 8.08081
583 1I2B NAD 8.08081
584 4Y30 SAH 8.08081
585 1I9G SAM 8.21429
586 3OU2 SAH 8.25688
587 2NXE SAM 8.26772
588 1ZEM NAD 8.39695
589 5BSZ SAH 8.4
590 4DMG SAM 8.41751
591 1UWK URO 8.41751
592 1UWK NAD 8.41751
593 1YBH FAD 8.41751
594 3AB1 FAD 8.41751
595 4YNU FAD 8.41751
596 4YNU LGC 8.41751
597 4PLG OXM 8.41751
598 4PLG NAI 8.41751
599 3P2E SAH 8.44444
600 1RP0 AHZ 8.4507
601 1XSE NDP 8.47458
602 3THR C2F 8.53242
603 3MB5 SAM 8.62745
604 2OBF SAH 8.65052
605 2OBF F83 8.65052
606 1G55 SAH 8.75421
607 3A25 SAM 8.75421
608 1V5F FAD 8.75421
609 1V5F TPP 8.75421
610 1R37 NAD 8.75421
611 3OFK SAH 8.7963
612 2QX0 PH2 8.80503
613 1G0N NDP 8.83392
614 1G0N PHH 8.83392
615 3TLJ SAH 9.09091
616 4ONQ SFG 9.09091
617 5W7K SAH 9.09091
618 4J36 FAD 9.09091
619 2E5V FAD 9.09091
620 4J36 1HR 9.09091
621 1KEW NAD 9.09091
622 1KEW TYD 9.09091
623 3WV8 ATP 9.17431
624 3AFN NAP 9.30233
625 3LCC SAH 9.3617
626 5GVR LMR 9.40171
627 1EFV FAD 9.41177
628 1EFV AMP 9.41177
629 4K26 NDP 9.42029
630 4K26 SFF 9.42029
631 4J56 FAD 9.42761
632 5UR0 NAD 9.42761
633 3JWH SAH 9.67742
634 5YF1 8V0 9.76431
635 5YF1 SFG 9.76431
636 3KLJ FAD 9.76431
637 2FK8 SAM 9.76431
638 1VKJ A3P 9.82456
639 4BLW AMP 10.0346
640 4BLW SAH 10.0346
641 5U19 827 10.101
642 5U19 SAH 10.101
643 1M32 PLP 10.101
644 4YSX FAD 10.2564
645 3H2B SAH 10.3448
646 1L3I SAH 10.4167
647 5M58 SAH 10.4348
648 4EMJ FAD 10.4377
649 5TVF PUT 10.5882
650 5E72 SAM 10.7744
651 2GN4 UD1 10.7744
652 2GN4 NDP 10.7744
653 2NVK FAD 11.1111
654 2GAG NAD 11.1111
655 3T7S SAM 11.194
656 3DUW SAH 11.2108
657 4NEC SAH 11.3636
658 1I8T FAD 11.4478
659 1VE3 SAM 11.4537
660 5ZW3 SAH 11.5556
661 1WY7 SAH 11.5942
662 5FA8 SAM 11.8012
663 5LOG SAH 12.0172
664 4KRG SAH 12.1212
665 4KGD FAD 12.1212
666 4KGD TDP 12.1212
667 1D4D FAD 12.1212
668 5JE0 AZ8 12.1457
669 5JE0 SAH 12.1457
670 4KIB SAH 12.3249
671 4O0L NDP 12.3636
672 4M73 SAH 12.4579
673 4M73 M72 12.4579
674 3EYA FAD 12.4579
675 4PLT OXM 12.4579
676 4PLT NAI 12.4579
677 4CQM NAP 12.7049
678 5MGZ SAH 12.7119
679 3WDM ADN 13.0268
680 6F5Z SAH 13.1148
681 3PFG TLO 13.308
682 3PFG SAM 13.308
683 3DMH SAM 13.8047
684 3DMH GMP 13.8047
685 5F8F SFG 14.1414
686 6FP4 E1T 14.4781
687 6FP4 FAD 14.4781
688 6GFK SAH 14.741
689 3Q87 SAM 15.2
690 3GDH SAH 15.3527
691 3HVJ 705 16.7421
692 1NM5 NAP 17.5084
693 1NM5 NAD 17.5084
694 2OOR TXP 17.5084
695 5UFN SAH 17.6471
696 3GD4 FAD 17.8451
697 3EGI ADP 17.9612
698 2JJQ SAH 18.5185
699 5E8J SAH 20.4545
700 5DXA SFG 31.5789
701 5DX1 SFG 31.5789
702 5DX8 SFG 31.5789
703 1NW5 SAM 35.3535
704 1G60 SAM 39.2308
Pocket No.: 2; Query (leader) PDB : 2ZIF; Ligand: SAM; Similar sites found with APoc: 143
This union binding pocket(no: 2) in the query (biounit: 2zif.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 2BOS GLA GAL GLC None
2 2BOS GLA GAL GLC NBU None
3 3R51 MMA None
4 4DS0 A2G GAL NAG FUC None
5 2Q37 3AL 1.65746
6 3ICT ADP 1.6835
7 3ICS ADP 1.6835
8 1E1M FAD 1.6835
9 1E1M NAP 1.6835
10 2YGM GLA NAG GAL FUC 1.6835
11 5AOA PPI 1.74825
12 1FUR MLT 2.0202
13 5OC1 FAD 2.0202
14 2CDU ADP 2.0202
15 2HJR APR 2.0202
16 5CK5 GDP 2.0202
17 1SOW NAD 2.0202
18 1DLJ NAI 2.0202
19 4RDH AMP 2.08333
20 4CS9 AMP 2.1164
21 3QVP FAD 2.3569
22 1PJS NAD 2.3569
23 5HSA FAS 2.3569
24 2ZL7 FUC GAL NGA 2.37288
25 5BSH PRO 2.52708
26 1XHC FAD 2.6936
27 2RGJ FAD 2.6936
28 1BW9 NAD 2.6936
29 3AYI HCI 2.6936
30 3AYI FAD 2.6936
31 1U1I NAD 2.6936
32 5HXI 5HN 2.6936
33 1KYQ NAD 2.91971
34 4U8P UDP 3.0303
35 5TUF TDC 3.0303
36 5T8U LPA 3.0303
37 4U8P FDA 3.0303
38 4L80 OXL 3.0303
39 2Q1S NAI 3.0303
40 2CXG GLC GLC 3.0303
41 2GMH FAD 3.0303
42 2IV2 MGD 3.0303
43 2VT3 ATP 3.25581
44 2NUO BGC 3.27869
45 2NU5 NAG 3.27869
46 5AHO TLA 3.367
47 5KMS NAD 3.367
48 2B9W FAD 3.367
49 5O4J PJL 3.367
50 5JE8 NAD 3.367
51 2IF8 ADP 3.367
52 6H3O FAD 3.367
53 4IN9 SER TRP PHE PRO 3.61446
54 4TXI FAD 3.7037
55 1D8C GLV 3.7037
56 3F8D FAD 3.7037
57 1GVF PGH 3.84615
58 5ZZ6 NAD 3.84615
59 5ZZ6 ADP 3.84615
60 3K7S R52 3.91061
61 2CHT TSA 3.93701
62 5T67 SAH 4.0404
63 1RJW ETF 4.0404
64 1FL2 FAD 4.0404
65 4XQC 13D 4.0404
66 4XQC NAD 4.0404
67 4ZVV NAD 4.0404
68 4ZVV GN0 4.0404
69 4IQY AR6 4.16667
70 1TZD ADP 4.36364
71 1NVM NAD 4.3771
72 2JK0 ASP 4.3771
73 3AD8 PYC 4.4335
74 3AD8 FAD 4.4335
75 3JUC PCA 4.57516
76 5N53 8NB 4.61538
77 1COY AND 4.7138
78 4YKG NAD 4.7138
79 4YKG FAD 4.7138
80 1UXG NAD 4.7138
81 1UXG FUM 4.7138
82 2GJP MAL 4.7138
83 4IP7 FBP 4.7138
84 3H8V ATP 4.79452
85 1TD2 PXL 4.87805
86 1P7T PYR 5.05051
87 1GUZ NAD 5.05051
88 2X2T GAL NGA 5.22876
89 1JXN MFU 5.3719
90 1YKJ FAD 5.38721
91 1YKJ PHB 5.38721
92 3P13 RIP 5.55556
93 1CBK ROI 5.625
94 1O97 AMP 5.68182
95 2DT5 NAD 5.6872
96 3NDJ SAH 5.72391
97 3NDJ JHZ 5.72391
98 2FZW NAD 5.72391
99 1ICV NIO 5.99078
100 4B2D FBP 6.06061
101 4RDN 6MD 6.58683
102 5TUK FAD 6.73401
103 5LW0 AR6 6.92641
104 3OZ2 FAD 7.07071
105 2YVF NAD 7.07071
106 2YVF FAD 7.07071
107 5A3B APR 7.07071
108 1Q1R FAD 7.40741
109 5L95 AMP 7.5
110 1S7G APR 7.50988
111 2A92 NAI 7.74411
112 2VNO GAL GAL FUC 8.33333
113 5MIT NAP 8.41751
114 5MIT FAD 8.41751
115 4Z0H NAD 8.41751
116 2HK9 ATR 8.72727
117 4XFR CIT 8.75421
118 5O42 9JW 8.75912
119 5O42 BGC 8.75912
120 5O42 NAD 8.75912
121 3QWI NAP 8.88889
122 1Y4Z PCI 9.77778
123 1OGD RIP 9.92366
124 4HSU FAD 10
125 4EMI FAD 10.4377
126 4EMI NAD 10.4377
127 1DMR PGD 10.4377
128 5TVF CGQ 10.5882
129 2GAG FAD 11.1111
130 2GAG FOA 11.1111
131 2DKH 3HB 12.1212
132 2DKH FAD 12.1212
133 4MCC 21X 12.6016
134 1T26 NAI 12.7946
135 1T26 GBD 12.7946
136 1NFQ NAI 13.4615
137 3QFA FAD 13.7931
138 2FKA BEF 14.7287
139 1JNR FAD 17.1717
140 3GD4 NAD 17.8451
141 5JCM FAD 17.8451
142 5JCM ISD 17.8451
143 5JCM NAD 17.8451
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