-->
Receptor
PDB id Resolution Class Description Source Keywords
2Z49 1.95 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF HEMOLYTIC LECTIN CEL-III COMPLEXED WITH METHYL-ALPHA-D-GALACTOPYLANOSIDE CUCUMARIA ECHINATA LECTIN CEL-III HEMOLYSIS HEMAGGLUTINATION PORE-FORMING CALCIUM MAGNESIUM METHYL-ALPHA-D-GALACTOPYLANOSIDE TOXIN
Ref.: C-TYPE LECTIN-LIKE CARBOHYDRATE-RECOGNITION OF THE HEMOLYTIC LECTIN CEL-III CONTAINING RICIN-TYPE BETA-TREFOIL FOLDS J.BIOL.CHEM. V. 282 37826 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AMG A:1400;
A:1401;
A:1402;
A:1403;
A:1404;
B:1405;
B:1406;
B:1407;
B:1408;
B:1409;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
194.182 C7 H14 O6 CO[C@...
CA A:1001;
A:1002;
A:1003;
A:1004;
A:1005;
B:1001;
B:1002;
B:1003;
B:1004;
B:1005;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
MG A:2001;
A:2002;
B:2001;
B:2002;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Z49 1.95 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF HEMOLYTIC LECTIN CEL-III COMPLEXED WITH METHYL-ALPHA-D-GALACTOPYLANOSIDE CUCUMARIA ECHINATA LECTIN CEL-III HEMOLYSIS HEMAGGLUTINATION PORE-FORMING CALCIUM MAGNESIUM METHYL-ALPHA-D-GALACTOPYLANOSIDE TOXIN
Ref.: C-TYPE LECTIN-LIKE CARBOHYDRATE-RECOGNITION OF THE HEMOLYTIC LECTIN CEL-III CONTAINING RICIN-TYPE BETA-TREFOIL FOLDS J.BIOL.CHEM. V. 282 37826 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 2Z49 - AMG C7 H14 O6 CO[C@@H]1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 2Z49 - AMG C7 H14 O6 CO[C@@H]1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 2Z49 - AMG C7 H14 O6 CO[C@@H]1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: AMG; Similar ligands found: 169
No: Ligand ECFP6 Tc MDL keys Tc
1 MMA 1 1
2 GYP 1 1
3 AMG 1 1
4 MBG 1 1
5 MAN MMA 0.651163 0.914286
6 GAL MBG 0.613636 0.914286
7 M13 0.613636 0.914286
8 DR5 0.613636 0.914286
9 MMA MAN 0.613636 0.914286
10 MDM 0.613636 0.914286
11 TRE 0.583333 0.857143
12 GLA MBG 0.581395 0.914286
13 MA3 0.525 0.914286
14 G1P 0.512195 0.674419
15 M1P 0.512195 0.674419
16 GL1 0.512195 0.674419
17 XGP 0.512195 0.674419
18 BQZ 0.5 0.878788
19 DEG 0.488889 0.837838
20 2M4 0.478261 0.857143
21 WZ1 0.470588 0.842105
22 MAG 0.468085 0.727273
23 EBQ 0.468085 0.861111
24 2F8 0.468085 0.727273
25 RGG 0.466667 0.909091
26 MAN MMA MAN 0.464286 0.914286
27 BGC SSG SSG SGC MA3 0.462963 0.842105
28 GLC SSG SGC SGC MA3 0.462963 0.842105
29 BGC SGC SGC GTM 0.462963 0.842105
30 GAL MGC 0.462963 0.680851
31 GAT 0.458333 0.674419
32 GLC HEX 0.458333 0.775
33 JZR 0.458333 0.775
34 BHG 0.458333 0.775
35 SMD 0.45098 0.842105
36 2GS 0.45 1
37 B7G 0.44898 0.756098
38 KGM 0.44898 0.756098
39 LAT GLA 0.446809 0.857143
40 2M8 0.446809 0.882353
41 GTM BGC BGC 0.442623 0.842105
42 BNG 0.44 0.756098
43 GLC GLO 0.44 0.909091
44 BOG 0.44 0.756098
45 HSJ 0.44 0.756098
46 R1P 0.439024 0.6
47 GLA GAL 0.4375 0.857143
48 GLC GAL 0.4375 0.857143
49 BGC BMA 0.4375 0.857143
50 LBT 0.4375 0.857143
51 LAT 0.4375 0.857143
52 EBG 0.4375 0.810811
53 MAL 0.4375 0.857143
54 MAN GLC 0.4375 0.857143
55 56N 0.4375 0.805556
56 GLA GLA 0.4375 0.857143
57 LB2 0.4375 0.857143
58 N9S 0.4375 0.857143
59 NGR 0.4375 0.857143
60 CBI 0.4375 0.857143
61 GAL BGC 0.4375 0.857143
62 M3M 0.4375 0.857143
63 MAB 0.4375 0.857143
64 BMA GAL 0.4375 0.857143
65 CBK 0.4375 0.857143
66 BGC GAL 0.4375 0.857143
67 B2G 0.4375 0.857143
68 GAL FUC 0.431373 0.857143
69 MBG A2G 0.431034 0.680851
70 A2G MBG 0.431034 0.680851
71 GLA BGC 0.428571 0.857143
72 GLC GLC 0.428571 0.857143
73 BGC GLA 0.428571 0.857143
74 MAN BMA 0.428571 0.857143
75 BMA MAN 0.428571 0.857143
76 MAN MAN 0.428571 0.857143
77 GLA GLC 0.428571 0.857143
78 BMA GLA 0.428571 0.857143
79 BGC GLC 0.428571 0.857143
80 GLC BGC 0.428571 0.857143
81 LAK 0.428571 0.857143
82 GAL GAL 0.428571 0.857143
83 MLB 0.428571 0.857143
84 GLA BMA 0.428571 0.857143
85 GAL GLC 0.428571 0.857143
86 WZ2 0.42623 0.842105
87 GLA EGA 0.423077 0.861111
88 GAL PHB 0.423077 0.783784
89 T6P 0.42 0.666667
90 RZM 0.42 0.666667
91 BGC BGC SGC MGL 0.415385 0.842105
92 MGL SGC GLC GLC 0.415385 0.842105
93 MGL SGC BGC BGC 0.415385 0.842105
94 BMA IFM 0.415094 0.652174
95 MAN MAN BMA 0.415094 0.857143
96 VAM 0.415094 0.842105
97 IFM BMA 0.415094 0.652174
98 BMA BMA MAN 0.415094 0.857143
99 IFM BGC 0.415094 0.652174
100 NAG MBG 0.413793 0.680851
101 HNV 0.413793 0.842105
102 WZ3 0.412698 0.888889
103 GLC GLC GLC 0.411765 0.857143
104 DOM 0.411765 0.810811
105 SWE 0.411765 0.789474
106 MAN MAN MAN 0.411765 0.857143
107 BGC BGC 0.411765 0.833333
108 BMA BMA 0.411765 0.833333
109 MAN 7D1 0.411765 0.810811
110 GLC GLC GLC GLC GLC BGC 0.411765 0.857143
111 BMA MAN MAN 0.411765 0.857143
112 SUC 0.411765 0.789474
113 GLC GLC GLC GLC BGC 0.411765 0.857143
114 MFB 0.410256 0.727273
115 MFU 0.410256 0.727273
116 XLM 0.407407 0.888889
117 DMJ MAN 0.407407 0.638298
118 NOJ BGC 0.407407 0.638298
119 GLC DMJ 0.407407 0.638298
120 3X8 0.407407 0.763158
121 FK9 0.407407 0.756098
122 GLC BGC BGC BGC BGC BGC 0.403846 0.857143
123 MTT 0.403846 0.857143
124 MT7 0.403846 0.857143
125 GLC BGC BGC BGC BGC 0.403846 0.857143
126 MLR 0.403846 0.857143
127 GLC BGC BGC BGC 0.403846 0.857143
128 BGC BGC BGC GLC 0.403846 0.857143
129 BGC BGC BGC BGC BGC 0.403846 0.857143
130 GLA GAL BGC 0.403846 0.857143
131 SER MAN 0.403846 0.697674
132 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.403846 0.857143
133 CEX 0.403846 0.857143
134 CE6 0.403846 0.857143
135 BGC GLC GLC GLC GLC GLC GLC 0.403846 0.857143
136 BMA BMA BMA 0.403846 0.857143
137 GLC GLC GLC GLC GLC 0.403846 0.857143
138 CTR 0.403846 0.857143
139 BMA MAN BMA 0.403846 0.857143
140 GLC GAL GAL 0.403846 0.857143
141 CE5 0.403846 0.857143
142 U63 0.403846 0.769231
143 BGC BGC BGC 0.403846 0.857143
144 CT3 0.403846 0.857143
145 GLA GAL GLC 0.403846 0.857143
146 DXI 0.403846 0.857143
147 BGC GLC GLC GLC 0.403846 0.857143
148 BGC BGC BGC BGC BGC BGC 0.403846 0.857143
149 GLC BGC GLC 0.403846 0.857143
150 MAN BMA BMA BMA BMA BMA 0.403846 0.857143
151 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.403846 0.857143
152 BGC GLC GLC GLC GLC 0.403846 0.857143
153 BGC BGC BGC BGC 0.403846 0.857143
154 CE8 0.403846 0.857143
155 CEY 0.403846 0.857143
156 MAN BMA BMA BMA BMA 0.403846 0.857143
157 BGC GLC GLC 0.403846 0.857143
158 BGC BGC GLC 0.403846 0.857143
159 BMA BMA BMA BMA BMA BMA 0.403846 0.857143
160 CTT 0.403846 0.857143
161 GLC GLC BGC 0.403846 0.857143
162 MAN MAN BMA BMA BMA BMA 0.403846 0.857143
163 GLC BGC BGC 0.403846 0.857143
164 MAN BMA BMA 0.403846 0.857143
165 B4G 0.403846 0.857143
166 BMA BMA BMA BMA BMA 0.403846 0.857143
167 GAL GAL GAL 0.403846 0.857143
168 GLC 7LQ 0.4 0.857143
169 IFM MAN 0.4 0.652174
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 260
This union binding pocket(no: 1) in the query (biounit: 2z49.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 5XG5 A2G None
2 3C0G 3AM 1.1396
3 4Y0X ADP 1.33333
4 5L01 6Z4 1.38889
5 4CRL C1I 1.40351
6 5THY SAH 1.48148
7 5IH9 6BF 1.49254
8 4BFM ANP 1.49701
9 5I35 ANP 1.52672
10 5MY8 RXZ 1.56658
11 4QTB 38Z 1.57895
12 4FCW ADP 1.60772
13 2VPQ ANP 1.62037
14 1GP6 QUE 1.68539
15 1GP6 SIN 1.68539
16 1GP6 DH2 1.68539
17 2V7O DRN 1.78571
18 2WU6 DKI 1.83727
19 3KFL ME8 1.85185
20 4O6M C5P 1.88172
21 6FGL UO1 1.90476
22 5J6D 6H5 1.9544
23 5AWM ANP 2.03046
24 1XSE NDP 2.0339
25 4XV1 904 2.05479
26 4WHZ 3NL 2.07792
27 1JG9 GLC 2.08333
28 6C6O ENG 2.08333
29 1R27 MGD 2.08333
30 1IXE COA 2.12202
31 3LU1 NAD 2.1978
32 2PZI AXX 2.20264
33 4WOP CTP 2.22222
34 4IDT T28 2.24719
35 6DVH FMN 2.28426
36 5T8O 76Z 2.29226
37 3TTI KBI 2.31481
38 6I6X H6B 2.31481
39 6I6R H62 2.31481
40 3WQT ANP 2.31481
41 5JBE GLC GLC GLC GLC GLC 2.31481
42 5JFL NAD 2.31481
43 2AF6 BRU 2.32558
44 3ZS7 ATP 2.33333
45 2P6W FLC 2.34742
46 3PP0 03Q 2.36686
47 6FYV 3NG 2.37389
48 4M73 SAH 2.37389
49 4M73 M72 2.37389
50 3AJ6 NGA 2.44755
51 3K5I ADP 2.48139
52 4C2C ALA VAL PRO ALA 2.5463
53 3GVL SLB SIA 2.5463
54 5KJK 6T1 2.5641
55 5KJK SAM 2.5641
56 2VNI FAD 2.57353
57 2VNI A2P 2.57353
58 5WBF LAC 2.59259
59 3G6K FAD 2.5974
60 3G6K POP 2.5974
61 5H2U 1N1 2.62172
62 5WO4 B7V 2.64901
63 4CLI 5P8 2.75229
64 4NM5 ADP 2.91777
65 1QO8 FAD 3.00926
66 2CSN CKI 3.0303
67 5ZTN CUR 3.0303
68 4NBI D3Y 3.04878
69 3ALN ANP 3.0581
70 2J4K U5P 3.09735
71 5EH0 5NW 3.10078
72 4WNP 3RJ 3.13589
73 3BXF 13P 3.13725
74 3F7Z 34O 3.14286
75 1NJR XYL 3.16901
76 5A6N U7E 3.18021
77 5OKT 9XK 3.18471
78 2X06 NAD 3.19767
79 5A89 ADP 3.20513
80 5A89 FMN 3.20513
81 1T9D FAD 3.24074
82 4IOK ADP 3.24074
83 4IOK XPO 3.24074
84 5C1P DAL DAL 3.26797
85 5C1P ADP 3.26797
86 6CE2 SVR 3.30579
87 5KTI TRE 6X6 3.3557
88 3RFV NAI 3.37079
89 2B9H ADP 3.39943
90 2B9F ADP 3.39943
91 5JGL SAM 3.46021
92 2V58 LZJ 3.47222
93 1VPM COA 3.5503
94 1PN4 HDC 3.57143
95 4Y8D 49J 3.57143
96 1DAK DPU 3.57143
97 1DAK ADP 3.57143
98 6FYL 3NG 3.58127
99 5BVE 4VG 3.60111
100 2BW7 ECS 3.65297
101 2BW7 APC 3.65297
102 4K49 HFQ 3.67647
103 1PHK ATP 3.69128
104 1J09 ATP 3.7037
105 1J09 GLU 3.7037
106 2QF7 AGS 3.7037
107 4XZ3 ACP 3.7037
108 5V49 8WA 3.7037
109 4WNK 453 3.7037
110 1GSA ADP 3.79747
111 2FV5 541 3.83142
112 5G6U YJM 3.83142
113 5VCV 1N1 3.85852
114 3EKK GS2 3.90879
115 1IA9 ANP 3.92857
116 6HLX G9Z 3.93519
117 1YBH FAD 3.93519
118 3VX3 ADP 4.03226
119 5X8I SQZ 4.04624
120 5EW9 5VC 4.05904
121 3HMO STU 4.09357
122 4K81 GTP 4.09357
123 5OFI 9TQ 4.09836
124 6G33 5ID 4.12979
125 1T36 ADP 4.16667
126 3H86 AP5 4.16667
127 2EV9 SKM 4.18251
128 1A59 COA 4.2328
129 5UIU 8CG 4.33437
130 4UXL 5P8 4.34783
131 1RZ0 FAD 4.34783
132 4AU8 Z3R 4.39189
133 6A1G 9OL 4.39815
134 3HZT J60 4.39815
135 1F7K UMP 4.41176
136 4R57 ACO 4.54545
137 3JYN NDP 4.61538
138 4L9I 8PR 4.62963
139 5JCM ISD 4.62963
140 4I54 1C1 4.62963
141 2C42 PYR 4.62963
142 2C42 TPP 4.62963
143 3WW2 SF9 4.6875
144 1EFV AMP 4.70588
145 1EFV FAD 4.70588
146 6F3G CJN 4.74576
147 4RHE FMN 4.78469
148 1CT9 GLN 4.86111
149 1CT9 AMP 4.86111
150 5O2D 9HH 5
151 1SG4 CO8 5
152 2CIG 1DG 5.03145
153 2C31 TZD 5.09259
154 2C31 ADP 5.09259
155 4X3R 686 5.09259
156 2VQD AP2 5.09259
157 1M0W ANP 5.09259
158 1D6Z HY1 5.09259
159 4K4D HFQ 5.10949
160 2QTR NXX 5.29101
161 4BCM T7Z 5.31561
162 2WK1 SAH 5.31915
163 4B0T ADP 5.32407
164 5DBV COA 5.32407
165 5EOB 5QQ 5.32915
166 4BCN T9N 5.33333
167 4G31 0WH 5.35117
168 3M2W L8I 5.35117
169 2OFV 242 5.41516
170 4LO2 GAL BGC 5.44218
171 1AUX AGS 5.46624
172 3LL4 2FP 5.47945
173 3OI7 OI7 5.47945
174 4M20 COA 5.51181
175 3RSC TYD 5.54217
176 5IBE 69M 5.55556
177 1PK8 ATP 5.55556
178 6AU6 GDP 5.57029
179 1JXZ BCA 5.57621
180 2GQT FAD 5.59701
181 3ZLR X0B 5.6962
182 2VZ6 FEF 5.7508
183 2IO8 ADP 5.78704
184 2WUF KEM 5.84192
185 5XET ME8 5.86011
186 6G34 5ID 5.88235
187 1ST0 GTG 5.93472
188 2I8T GDD 5.98802
189 4KBA 1QM 6.0423
190 5W4W 9WG 6.0423
191 2ISJ FMN 6.08696
192 3PVW QRX 6.17647
193 5DRB 5FJ 6.18557
194 5UKL SIX 6.19469
195 3A6T 8OG 6.20155
196 4H3Q ANP 6.35359
197 4H3P ANP 6.35359
198 4ZOH FAD 6.47482
199 4OUJ LBT 6.51466
200 5LPG 71V 6.70732
201 6HSP CO8 6.76329
202 6HSP COA 6.76329
203 2WDQ TEO 6.94444
204 3IAA TYD 6.97115
205 3KN5 ANP 7.07692
206 2X2T GAL NGA 7.18954
207 3SRV S19 7.22022
208 4F07 FAD 7.36842
209 2YAB AMP 7.47922
210 1PI5 SM2 7.82123
211 5VZ0 ADP 7.87037
212 3R35 4CO 7.94702
213 1PTR PRB 8
214 3S6X SIA GAL BGC 8
215 4UX9 ANP 8.51648
216 5ANU 58T 8.86076
217 1A2C 34H LEU PRJ OAR 8.88031
218 1UAD GNP 9.09091
219 5M3E APR 9.09091
220 1YBU APC 9.23913
221 5LRT ADP 9.49074
222 1Q5H DUD 9.52381
223 1HFE CYS 9.7561
224 4IEN GDP 9.81595
225 2EC9 24X 10
226 4ZS4 ATP 10.4235
227 1QAW TRP 10.8108
228 2GJ8 ALF GDP 11.0465
229 4L2I FAD 11.2717
230 4ZJS 4P0 11.3043
231 6CEN ACE GLY VAL NLE ARG ILE NH2 11.8421
232 2B99 RDL 12.1795
233 2VN9 GVD 12.2924
234 3ZZQ TRP 12.3077
235 3ZZS TRP 12.3077
236 3AIA SAM 12.3223
237 3PNL ADP 12.3223
238 2HK9 SKM 12.7273
239 1WHT BZS 13.0719
240 2OI9 GLN LEU SER PRO PHE PRO PHE ASP LEU 13.2231
241 3A23 GAL 13.4259
242 4OWK NGA 13.7681
243 4G9N NGA 13.986
244 4CL6 7SB 14.6199
245 1WN3 HXC 14.7059
246 2D24 XYS XYS 15.2778
247 3ZZL TRP 15.7143
248 1WAP TRP 16
249 3QBT GNP 16.4286
250 2ZV2 609 16.443
251 2A5F GTP 16.5714
252 2W83 GTP 16.9697
253 6F5Z SAH 18.0328
254 5K2M ADP 18.8679
255 6C90 ADP 19.2308
256 1UPT GTP 21.6374
257 1O3Y GTP 22.2892
258 1J2J GTP 22.2892
259 2J59 GTP 22.2892
260 4ZGR NGA GAL 31.4176
Pocket No.: 2; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 64
This union binding pocket(no: 2) in the query (biounit: 2z49.bio1) has 6 residues
No: Leader PDB Ligand Sequence Similarity
1 3WEC AUI 0.954654
2 4G1V FAD 1.50376
3 5KD6 6C7 1.67064
4 2V7T SAH 1.67224
5 5OLZ T4E 1.85185
6 2Q37 3AL 2.20994
7 5G57 6M5 2.22222
8 4USF 6UI 2.30263
9 1Q9I FAD 2.31481
10 1Q9I TEO 2.31481
11 2J6U DGT 2.51397
12 4NJH SAM 2.6087
13 4NJH 2K8 2.6087
14 3X01 AMP 2.79898
15 6G1P CIT 2.85714
16 2QV6 GTP 2.98507
17 3TM0 B31 3.04183
18 3TM0 ANP 3.04183
19 5B6I ADN 3.1348
20 2WBV SIA 3.1746
21 4GAH 0ET 3.34928
22 3V4S ATP 3.35917
23 5UQW GDP 3.7037
24 4XYM A12 3.7037
25 3WDM ADN 3.83142
26 1IR3 ANP 3.92157
27 2VSS ACO 4.34783
28 1ZX5 LFR 4.66667
29 4CNG SAH 4.70588
30 1Z06 GNP 4.7619
31 5L13 6ZE 5.09259
32 3OZV FAD 5.21092
33 4NZ4 NDG 5.2506
34 3ZXR IQ1 5.32407
35 3ZXR P3S 5.32407
36 1B7H LYS NLE LYS 5.32407
37 4RGQ 13P 5.43478
38 4RGQ NDP 5.43478
39 4ZFL 4NK 5.55556
40 5UAV TFB 5.59006
41 5UAV NDP 5.59006
42 1MEX RAC 5.6338
43 3BEO UDP 5.86667
44 3CF6 SP1 5.98802
45 5WYZ 7VF 6.01852
46 3OKP GDD 6.34518
47 3OKA GDD 6.56168
48 3N1S 5GP 6.72269
49 3UIM ANP 6.74847
50 4F4P 0SB 7.32601
51 1OS7 TAU 8.48057
52 1OS7 AKG 8.48057
53 5G41 AP5 8.52018
54 4MKF AP5 8.75576
55 3ZZH NLG 8.79479
56 6GD6 EVB 9.25926
57 5L4R CPT 10.1449
58 3DOE GTP 10.4167
59 4ODT GP1 Z9M 14.1593
60 4IGQ THR M3L GLN 15
61 2BKK ADP 15.9763
62 3PCR GTP 17.284
63 3MJH GTP 20.5882
64 1R4A GNP 23.0303
Pocket No.: 3; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 150
This union binding pocket(no: 3) in the query (biounit: 2z49.bio1) has 7 residues
No: Leader PDB Ligand Sequence Similarity
1 1BZL FAD 0.925926
2 2BJK NAD 1.15741
3 1PFY MSP 1.38889
4 2X24 X24 1.62037
5 3VPD ANP 1.77936
6 6EKZ SNP 1.82927
7 6FK3 PPI 1.85185
8 2PTZ PAH 1.85185
9 2PAR TMP 1.99005
10 6HTO 5AD 2
11 6HTO MET 2
12 2R09 4IP 2.01729
13 2R0D 4IP 2.01729
14 4MZQ 1VU 2.08333
15 2Q8M FBP 2.10843
16 3KJD 78P 2.17391
17 1U7Z PMT 2.21239
18 4YEE 4CQ 2.22222
19 4PXL NAD 2.31481
20 1B55 4IP 2.36686
21 1K7L 544 2.43056
22 2QE0 NAP 2.5463
23 2IMW DDS 2.58621
24 2NPA MMB 2.59259
25 5TH5 7C5 2.6616
26 2IMP NAI 2.77778
27 3RHJ NAP 2.77778
28 5L2M 6ZY 2.77778
29 2RHW C0E 2.82686
30 5JF2 SF7 2.94118
31 2O07 SPD 2.96053
32 3PLS ANP 3.02013
33 2YK7 CSF 3.06748
34 5FRD COA 3.07692
35 3GE7 AFQ 3.10881
36 5ZFI 9C9 3.125
37 4YZC STU 3.20988
38 4TVD BGC 3.24074
39 4IPH 1FJ 3.25203
40 3ITJ FAD 3.25444
41 2WKQ GTP 3.31325
42 3V4S ADP 3.35917
43 1NB9 ADP 3.40136
44 1NB9 RBF 3.40136
45 5FIT AP2 3.40136
46 1XVA SAM 3.42466
47 1FP6 ADP 3.46021
48 4ZVF GAV 3.48837
49 3C3N FMN 3.52564
50 5JKG 6LF 3.53698
51 2Z9I GLY ALA THR VAL 3.7037
52 1O9J NAD 3.7037
53 3VPH OXM 3.87097
54 3VPH NAD 3.87097
55 3FXU TSU 3.93443
56 5A3T MMK 3.93519
57 4I94 ANP 4
58 2WE0 UMP 4.1958
59 1CLU DBG 4.21687
60 2VSU ACO 4.36364
61 4EJN 0R4 4.39815
62 1CSI OAA 4.39815
63 1CSI CMX 4.39815
64 4XBA GMP 4.5
65 4XBA 5GP 4.5
66 1S8F GDP 4.51977
67 1TU3 GNP 4.67836
68 5VKT NAP 4.69613
69 3WCS MAN NAG GAL 4.72441
70 4IZC 1GZ 4.72727
71 5MW8 ATP 4.86111
72 2RIF AMP 4.96454
73 2PT9 2MH 4.98442
74 2GJ3 FAD 5
75 2WME NAP 5.09259
76 3KOX Z98 5.09259
77 2WOX NDP 5.09259
78 2G50 ALA 5.09259
79 3DCJ THH 5.11628
80 4Q5H ANP 5.12821
81 5NKN LOC 5.17241
82 5IUW NAD 5.23139
83 1A4R GDP 5.2356
84 4M37 SAH 5.24781
85 4M38 SAH 5.24781
86 5J75 6GQ 5.30303
87 5G3Y ADP 5.30973
88 3QO8 SSA 5.32407
89 1CS4 101 5.32995
90 1CS4 FOK 5.32995
91 4GLJ RHB 5.38721
92 4QVX 3CQ 5.38922
93 1FHX 4IP 5.42636
94 5VYH FOL 5.53936
95 5HPZ 68G 5.58659
96 5NJI 8Z2 5.59006
97 3O2Q PRO THR SEP PRO SER TYR 5.69801
98 2ZUX RAM 5.78704
99 5DZT AMP 5.78704
100 5C79 PBU 6
101 4POJ 2VP 6.06061
102 4M8E 29V 6.06061
103 5RHN 8BR 6.08696
104 4PZ2 NAD 6.25
105 2YIP YIO 6.52174
106 2J8C U10 6.53846
107 2HFP NSI 6.73759
108 2CYE COA 6.76692
109 4XJC TTP 6.77966
110 2P4Y C03 6.85921
111 2E5A LAQ 6.91643
112 1FM9 570 6.98529
113 3FUR Z12 6.98529
114 3H0A D30 6.98529
115 4OBW SAM 7.00389
116 3G9E RO7 7.01107
117 1YBQ BDH 7.17949
118 2ZWI C5P 7.23861
119 5VM6 9EG 7.29927
120 1N07 FMN 7.36196
121 5ETR 5RW 7.45342
122 5ETR APC 7.45342
123 5FLJ QUE 7.52688
124 2YW2 ATP 7.54717
125 1G1T SIA GAL MAG FUC 7.64331
126 4INI AMP 7.69231
127 3T6E MQ9 7.75194
128 1SL3 170 8.01394
129 5KF6 NAD 8.10185
130 3UG4 AHR 8.10185
131 1UPR 4IP 8.94309
132 4AX9 N5N 8.94942
133 1KJ8 GAR 8.95141
134 1KJ8 ATP 8.95141
135 1WUR 8DG 9.09091
136 2PRG BRL 9.09091
137 1ZPT FAD 9.53947
138 2WR8 SAH 9.65251
139 2ZX2 RAM 9.74359
140 6BQ6 TER 10.574
141 1S7N COA 11.5385
142 4YGF AZM 11.9658
143 4WP9 ZDA 12.4294
144 4WNB 4BN 13.1783
145 1Z0N BCD 14.5833
146 5KK4 44E 14.5833
147 4KAX 4IP 16.568
148 4YEF 4CQ 16.8539
149 2V92 ATP 22.293
150 2V92 AMP 22.293
Pocket No.: 4; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 31
This union binding pocket(no: 4) in the query (biounit: 2z49.bio1) has 6 residues
No: Leader PDB Ligand Sequence Similarity
1 5KOX FAD 1.38889
2 5KOX RFP 1.38889
3 6FUL E7Z 1.85185
4 1GS5 ANP 2.32558
5 1GS5 NLG 2.32558
6 1S4M LUM 2.38908
7 3QWB NDP 2.39521
8 2XCU C5P 2.40642
9 4TS1 TYR 3.1348
10 5B3A 0JO 3.59897
11 1PNO NAP 3.88889
12 2OOR TXP 4.16667
13 6BVI GNP 4.19162
14 6D5G GNP 4.19162
15 6D5L GNP 4.19162
16 6D5M GNP 4.19162
17 6D5H GNP 4.19162
18 1YF4 CYS TYR PHE GLN ASN CYS PRO ARG GLY NH2 4.4843
19 3OZV ECN 5.21092
20 1GR0 NAD 5.72207
21 4HVA 4HV 6.48148
22 5EPL 5R0 PHE ALA LEU ELY 5R5 6.66667
23 4YNM SAM 7.52212
24 2H88 TEO 7.93651
25 5ML0 P2L 9.09091
26 3B6O TMP 9.31174
27 3P3G UKW 10.3333
28 3P3G 3P3 10.3333
29 5MLJ 9ST 11.6071
30 3PDT ADP 12.7273
31 3WYF GTP 15.5251
Pocket No.: 5; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 62
This union binding pocket(no: 5) in the query (biounit: 2z49.bio1) has 7 residues
No: Leader PDB Ligand Sequence Similarity
1 2FSH ANP 1.15741
2 1RF6 GPJ 1.40515
3 1RF6 S3P 1.40515
4 3ZIU LSS 1.62037
5 1SB8 UD2 1.70455
6 3H55 GLA 1.75
7 4ANP 3QI 1.85185
8 4N8I COA 1.85185
9 6H45 QEI 2.04082
10 3KH5 AMP 2.14286
11 3KH5 ADP 2.14286
12 3AWJ COA 2.23881
13 3TDC 0EU 2.31481
14 4QRH 0O2 2.38095
15 4UCI ADN 2.40964
16 5KO1 6UY 2.4735
17 4EN4 GT1 2.5641
18 4EN4 ATP 2.5641
19 4EN4 GT0 2.5641
20 6AIX A3P 2.6455
21 6CZ3 FLJ 2.65152
22 4ZLU 4PW 2.77778
23 4ZLU ADP 2.77778
24 5ULJ 0WD 3.2419
25 2Q2Y ADP 3.26975
26 2Q2Y MKR 3.26975
27 3C6K SPD 3.41207
28 3C6K MTA 3.41207
29 1V9N NDP 3.61111
30 2C7G ODP 3.93519
31 2C7G FAD 3.93519
32 2D3M COA 3.94089
33 1YQS BSA 4.01146
34 1XUJ BOZ 4.4843
35 1SVK ALF GDP 4.53258
36 1YRE COA 4.56853
37 4WZ8 3W7 4.62963
38 1R2Q GNP 4.70588
39 1XOC VAL ASP SER LYS ASN THR SER SER TRP 4.86111
40 2JFN UMA 4.91228
41 1P6O HPY 4.96894
42 3P9Y N7P THR SEP PRO SER TYR SET 5.05051
43 3KO8 NAD 5.12821
44 6GNA FAD 5.20833
45 1L3I SAH 5.20833
46 5IUW IAC 5.23139
47 4I9B NAD 5.32407
48 4RVU NDP 5.42169
49 1VBI NAD 5.81395
50 5Z21 NAI 5.86592
51 1MH1 GNP 5.91398
52 1UYY BGC BGC 6.87023
53 2V0C LEU LMS 6.94444
54 4JAL SAH 7.78443
55 3N3T C2E 7.82313
56 3CV3 UDP 8.12808
57 3IWJ NAD 9.49074
58 6ASZ GLN THR ALA ARG M3L SER 10.1449
59 2FXU BID 10.4
60 5L2Z 70C 12.069
61 2F5Z FAD 14.0625
62 3RNM FAD 17.2414
Pocket No.: 6; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 14
This union binding pocket(no: 6) in the query (biounit: 2z49.bio2) has 6 residues
No: Leader PDB Ligand Sequence Similarity
1 4BR5 ANP 1.38889
2 1KRP DT DT PST 1.62037
3 1RPN GDP 1.79104
4 5LB3 ADP 3.24074
5 5X0J SEP 3.30579
6 5X0J AMP 3.30579
7 3NW7 LGV 4.23453
8 2YNE YNE 5.20833
9 2YNE NHW 5.20833
10 6BSX GDP 5.61798
11 3GYQ SAM 6.25
12 1H6W SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 8.01282
13 4E03 ADP 13.1068
14 3NK7 SAM 15.5235
Pocket No.: 7; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 36
This union binding pocket(no: 7) in the query (biounit: 2z49.bio2) has 7 residues
No: Leader PDB Ligand Sequence Similarity
1 1FEC FAD 1.15741
2 4YWV SSN 1.15741
3 1T90 NAD 1.38889
4 1D4D SIN 1.85185
5 4I3V NAD 2.5463
6 2ART LPA AMP 2.67176
7 1G0H IPD 2.77778
8 3VHE 42Q 2.78552
9 5TC4 L34 3.48101
10 2X2M X2M 3.50318
11 6A46 DCM 3.51562
12 2DM6 NAP 3.6036
13 2NP9 YE1 3.7037
14 4ZUL UN1 3.7037
15 3CRZ NAP 3.89105
16 1VDC FAD 3.9039
17 1Z83 AP5 4.08163
18 4MAF ADX 4.20792
19 2Q4H AMP 4.2735
20 4V3C C 4.38144
21 3VBK COA 4.39024
22 4C5N ACP 5.07246
23 4C5N PXL 5.07246
24 2PHN GDP 5.11811
25 3FGC FMN 5.12048
26 1G8K MGD 5.32407
27 3TAY MN0 5.52147
28 4TWP AXI 5.53506
29 2H21 SAM 5.55556
30 4BS0 6NT 5.78704
31 3TDV GDP 5.88235
32 4OUC 5ID 5.88235
33 4ZDJ UTP 6.01852
34 2IHK CSF 6.51629
35 2OZE AGS 8.72483
36 1EB1 ZAL PRO MMO 8.94942
Pocket No.: 8; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 66
This union binding pocket(no: 8) in the query (biounit: 2z49.bio2) has 7 residues
No: Leader PDB Ligand Sequence Similarity
1 3UN3 G16 1.50376
2 1D6H COA 1.55039
3 2I4I AMP 1.91847
4 1OS1 ATP 2.08333
5 1OS1 PYR 2.08333
6 3DOO SKM 2.16606
7 4IJP 1EH 2.23464
8 5LVP ATP 2.2508
9 1Y0Y L2O VAL VAL ASP 2.26629
10 4OAV ACP 2.31481
11 5WA0 MSS 2.46575
12 3GAY P6T 2.47678
13 4PX9 ADP 2.73973
14 3CH6 311 2.7972
15 3CH6 NAP 2.7972
16 2Z7R STU 2.80374
17 6FA4 GNP 2.89017
18 2WQN ADP 2.90323
19 1OSS BEN 3.13901
20 5NUE NAD 3.31325
21 4LHW GNP 3.44828
22 3WO0 ADP 3.7037
23 3WO0 ALA 3.7037
24 5OCG GNP 3.7037
25 4WB6 ATP 3.71429
26 1VHT BA3 4.12844
27 6D56 GNP 4.19162
28 6D5E GNP 4.19162
29 6D55 GNP 4.19162
30 6D5J GNP 4.19162
31 6BVL GNP 4.19162
32 6BVM GNP 4.19162
33 6BVJ GNP 4.19162
34 6BVK GNP 4.19162
35 6D59 GNP 4.19162
36 6D5V GNP 4.19162
37 1NVV GNP 4.21687
38 6A8H AHR AHR AHR 4.6729
39 1I1E DM2 4.86111
40 4O1P ANP 4.86111
41 1QL9 ZEN 4.93274
42 1JJV ATP 5.33981
43 3QXC ATP 5.78512
44 5OYH T99 6.21762
45 4NAT 2W5 6.25
46 4NAT ADP 6.25
47 5B47 PYR 6.25
48 5B47 TPP 6.25
49 3V8S 0HD 6.58537
50 3DDC GNP 6.74847
51 5IXK 6EW 7.01754
52 5T0K SAM 7.11744
53 2C5L GTP 7.69231
54 3O0G 3O0 8.05369
55 4AUA 4AU 8.14332
56 4BHN BH9 8.38323
57 4K33 ACP 9.84615
58 4ZG4 VO4 ADP 10.1852
59 2BDG PBZ 10.7623
60 3MWL 8OX 11.1111
61 6CHP F0Y 11.8012
62 2TPI ILE VAL 12.069
63 5LXM ADP 18.4211
64 2WEL K88 19.3333
65 1GJC 130 21.7391
66 1S9D AFB 23.1707
Pocket No.: 9; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 8
This union binding pocket(no: 9) in the query (biounit: 2z49.bio2) has 6 residues
No: Leader PDB Ligand Sequence Similarity
1 5Q0F 9FA 1.63934
2 5WB6 9ZM 1.63934
3 2QA1 FAD 2.77778
4 4K5S PM0 4.85075
5 4K5S FAD 4.85075
6 4N9I PCG 8.09524
7 5XWV 8H6 11.4919
8 5XWV NDP 11.4919
Pocket No.: 10; Query (leader) PDB : 2Z49; Ligand: AMG; Similar sites found with APoc: 162
This union binding pocket(no: 10) in the query (biounit: 2z49.bio2) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 3TY3 GGG 1.36612
2 3EHH ADP 1.37615
3 3TXO 07U 1.41643
4 1T57 FMN 1.45631
5 4ONA UW1 1.62037
6 5BSR AMP 1.62037
7 1VBH PEP 1.62037
8 3JDW ORN 1.65485
9 1XON PIL 1.7192
10 5VC5 96M 1.7301
11 4L9Z COA 1.76991
12 4KXV TDP DX5 1.85185
13 1KC7 PPR 1.85185
14 1ON3 MCA 1.85185
15 3ZRM ZRM 1.88679
16 5MJA 7O3 1.96721
17 6AMI TRP 2.0202
18 6AM8 PLT 2.0202
19 6CUZ FEV 2.06186
20 1OFL ASG GCD 2.08333
21 4OHY ANP 2.08817
22 5HES 032 2.28013
23 2WPB ZZI 2.30263
24 3TKA SAM 2.30548
25 1TKB N1T 2.31481
26 2R5N TPP 2.31481
27 2R5N RP5 2.31481
28 3GD4 NAD 2.31481
29 3NJ4 AFX 2.31481
30 1TLL FMN 2.31481
31 3D3X ARG ILE MET GLU NH2 2.34192
32 4RIF 3R2 2.37467
33 1H5S TMP 2.38908
34 1IIM TTP 2.39726
35 1S68 AMP 2.40964
36 3BBH SFG 2.43902
37 5DN9 NAD 2.47253
38 2ZJ1 NAD 2.5463
39 2ZJ1 ARJ 2.5463
40 5M77 7K2 7K3 2.5463
41 1XJD STU 2.6087
42 4JR7 GNP 2.6738
43 6FDF SAH 2.69461
44 4ZVV NAD 2.71084
45 4ZVV GN0 2.71084
46 5X2Z 3LM 2.76382
47 5X30 7XF 2.76382
48 4DC2 ADE 2.77778
49 5J60 FAD 2.8125
50 5O96 SAM 2.85714
51 4JWJ SAH 2.9703
52 1DMR PGD 3.00926
53 5M67 ADE 3.00926
54 5M67 NAD 3.00926
55 5M67 3D1 3.00926
56 5N0F 7K2 3.03867
57 5A7V MAN 3.09278
58 5LI1 ANP 3.10734
59 4YZN 4K5 3.13589
60 2YAK OSV 3.15789
61 3VRY B43 3.24074
62 1V8B ADN 3.24074
63 5WKC FAD 3.24074
64 1XKD NAP 3.24074
65 5XFV FMN 3.29341
66 4XTX 590 3.33333
67 2B9I ADP 3.39943
68 2B9J ADP 3.39943
69 1RE8 BD2 3.42857
70 2AIQ BEN 3.4632
71 3AI7 TPP 3.47222
72 1IHU AF3 3.47222
73 5XU2 8EL 3.47222
74 5XU2 TPP 3.47222
75 5XU2 F6R 3.47222
76 1IHU ADP 3.47222
77 4LS7 1X9 3.52113
78 3WSG CIT 3.57143
79 5NUL FMN 3.62319
80 2ZA5 2FF 3.67347
81 1H65 GDP 3.7037
82 3LAD FAD 3.7037
83 5F7R GLC GLC 3.71287
84 5KZD RCJ 3.75427
85 2I6A 5I5 3.76812
86 5G1X ADP 3.85965
87 3AHC TPP 3.93519
88 3O8M BGC 3.93519
89 3O8M GLC 3.93519
90 2F2U M77 3.9801
91 4L50 D8X 4.13534
92 5TCI MLI 4.34783
93 1K3A ACP 4.34783
94 6H3O FAD 4.39815
95 4KM2 ATR 4.46927
96 2WOJ ADP ALF 4.51977
97 1JIL 485 4.52381
98 1WG8 SAM 4.5614
99 1GQ2 NAP 4.62963
100 1MMQ RRS 4.70588
101 1G51 AMO 4.86111
102 5FSY AR6 4.88722
103 4L3L 5FI 4.93421
104 5CEO 50D 5
105 4R2M ANP 5.06329
106 4OCJ NDG 5.27704
107 1RM0 D6P 5.32407
108 4IMG NGF 5.46075
109 4PVR ASP 5.48387
110 3KAL ADP 5.55556
111 5Z7B VNL 5.55556
112 3AB4 LYS 5.61798
113 4FG8 ATP 5.71429
114 3FHI ANP 5.84416
115 3X1Z GNP 5.98802
116 3EFS BTN 6.00858
117 2X3J ATP 6.01852
118 6GQM F8H 6.09756
119 2F57 23D 6.30915
120 5J6C FMN 6.46766
121 4N82 FMN 6.74157
122 3ORF NAD 6.77291
123 2VJM COA 6.7757
124 1VGR COA 6.79157
125 4AVV CD 6.86275
126 4AVV GHE 6.86275
127 1E96 GTP 6.89655
128 1V0O INR 6.94444
129 3E7O 35F 6.94444
130 2UZI GTP 7.01754
131 1NLU IVA PHI TYB 7.02703
132 4IQY AR6 7.08333
133 2YVJ FAD 7.33945
134 3ZQ6 ADP ALF 7.40741
135 4KQW NAP 7.42857
136 1BVY FMN 7.8534
137 4DVR 0LY 8.01887
138 2GSD NAD 8.20895
139 3OII SAH 8.3004
140 2VNF ALA ARG THR M3L GLN THR ALA ARG LYS SER 8.33333
141 5YF9 NIO 8.55457
142 2QCS ANP 8.59107
143 1APZ ASP 8.64198
144 4I53 1C1 8.65922
145 1YAG ATP 8.8
146 3HGM ATP 8.84354
147 4JWH SAH 8.94569
148 3AI8 HNQ 8.98438
149 1XKQ NDP 9.28571
150 1FFU FAD 9.40767
151 1NUS APC 9.52381
152 4B1W ATP 10.3723
153 2FXU ATP 10.4
154 5VEG FMN 10.6742
155 1VA6 ADP 11.3426
156 4UME KDO 11.399
157 5N53 8NB 11.7949
158 1I52 CTP 12.7119
159 5H5F SAM 13.2479
160 2AMT 1AA 15.0943
161 5LU5 M7P 15.2284
162 1CXZ GSP 16.2791
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