Receptor
PDB id Resolution Class Description Source Keywords
2YY8 2.48 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ARCHAEAL TRNA-METHYLASE FOR POSITION 56 (ATRM56) FROM PYROCOCCUS HORIKOSHII, COMPLEXED WITH S- A DENOSYL-L-METHIONINE PYROCOCCUS HORIKOSHII DEEP TREFOIL KNOT STRUCTURAL GENOMICS NPPSFA NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE RSGI TRANSFERASE
Ref.: CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF A UNIQUE SPOU FAMILY ARCHAEAL METHYLASE THAT FORMS 2'-O-METHYLCYTIDINE AT POSITION 56 OF TRNA J.MOL.BIOL. V. 375 1064 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MTA A:400;
Valid;
none;
submit data
297.334 C11 H15 N5 O3 S CSC[C...
SAM B:500;
Valid;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2YY8 2.48 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ARCHAEAL TRNA-METHYLASE FOR POSITION 56 (ATRM56) FROM PYROCOCCUS HORIKOSHII, COMPLEXED WITH S- A DENOSYL-L-METHIONINE PYROCOCCUS HORIKOSHII DEEP TREFOIL KNOT STRUCTURAL GENOMICS NPPSFA NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE RSGI TRANSFERASE
Ref.: CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF A UNIQUE SPOU FAMILY ARCHAEAL METHYLASE THAT FORMS 2'-O-METHYLCYTIDINE AT POSITION 56 OF TRNA J.MOL.BIOL. V. 375 1064 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 2YY8 - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 2YY8 - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 2YY8 - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MTA; Similar ligands found: 256
No: Ligand ECFP6 Tc MDL keys Tc
1 MTA 1 1
2 DTA 0.786885 0.867647
3 3DH 0.777778 0.938462
4 RAB 0.758621 0.878788
5 XYA 0.758621 0.878788
6 ADN 0.758621 0.878788
7 DSH 0.705882 0.84507
8 5N5 0.704918 0.878788
9 A4D 0.693548 0.907692
10 5CD 0.693548 0.892308
11 EP4 0.6875 0.939394
12 M2T 0.676923 0.940298
13 A7D 0.657534 0.882353
14 5X8 0.64 0.895522
15 5AD 0.639344 0.857143
16 ZAS 0.628571 0.816901
17 AMP 0.628571 0.794521
18 A 0.628571 0.794521
19 A5D 0.623377 0.867647
20 SAH 0.615385 0.869565
21 ABM 0.60274 0.821918
22 J7C 0.60274 0.794521
23 AAT 0.6 0.797297
24 6RE 0.597222 0.783784
25 SRA 0.597222 0.776316
26 S4M 0.594595 0.84
27 AOC 0.589041 0.880597
28 AMP MG 0.589041 0.773333
29 MAO 0.586667 0.805195
30 S8M 0.583333 0.833333
31 A2D 0.581081 0.773333
32 A3N 0.581081 0.867647
33 5AS 0.578947 0.697674
34 GJV 0.573333 0.773333
35 BA3 0.565789 0.773333
36 A12 0.565789 0.74359
37 AP2 0.565789 0.74359
38 M33 0.564103 0.810811
39 AU1 0.564103 0.753247
40 MHZ 0.564103 0.805195
41 ADX 0.564103 0.719512
42 ADP 0.558442 0.773333
43 AP5 0.558442 0.773333
44 B4P 0.558442 0.773333
45 7D7 0.553846 0.794118
46 Y3J 0.552239 0.80303
47 AN2 0.551282 0.763158
48 SON 0.551282 0.74359
49 SXZ 0.550562 0.849315
50 PRX 0.55 0.8
51 A6D 0.545455 0.766234
52 CA0 0.544304 0.753247
53 ADP MG 0.544304 0.763158
54 SA8 0.54321 0.873239
55 AD9 0.54321 0.753247
56 EEM 0.542169 0.849315
57 BEF ADP 0.5375 0.74359
58 50T 0.5375 0.763158
59 SFG 0.5375 0.826087
60 ACP 0.5375 0.753247
61 ATP 0.5375 0.773333
62 ADP BEF 0.5375 0.74359
63 AR6 0.530864 0.773333
64 APR 0.530864 0.773333
65 5FA 0.530864 0.773333
66 APC 0.530864 0.74359
67 AQP 0.530864 0.773333
68 ANP 0.53012 0.753247
69 SAM 0.53012 0.875
70 SMM 0.529412 0.84
71 3AM 0.527027 0.756757
72 NEC 0.526316 0.823529
73 RBY 0.52439 0.74359
74 SAP 0.52439 0.75641
75 AGS 0.52439 0.75641
76 ADP PO3 0.52439 0.794521
77 ADV 0.52439 0.74359
78 5AL 0.52381 0.786667
79 VMS 0.523256 0.705882
80 54H 0.523256 0.705882
81 3AD 0.521739 0.863636
82 MTH 0.520548 0.984127
83 SAI 0.518072 0.830986
84 G5A 0.518072 0.678161
85 ATP MG 0.518072 0.763158
86 A5A 0.517647 0.722892
87 ME8 0.516484 0.797468
88 ACQ 0.511905 0.753247
89 GAP 0.511905 0.753247
90 TAT 0.511905 0.766234
91 S7M 0.511628 0.824324
92 8QN 0.511364 0.786667
93 CC5 0.507463 0.876923
94 A3G 0.506494 0.828571
95 A3P 0.506329 0.77027
96 52H 0.505747 0.697674
97 MTP 0.5 0.828571
98 ADP ALF 0.5 0.734177
99 MAP 0.5 0.734177
100 TSB 0.5 0.714286
101 7D5 0.5 0.714286
102 ATF 0.5 0.74359
103 ALF ADP 0.5 0.734177
104 53H 0.5 0.697674
105 DAL AMP 0.5 0.786667
106 5SV 0.494382 0.759494
107 25A 0.494382 0.773333
108 SSA 0.494253 0.678161
109 ANP MG 0.494253 0.734177
110 ADP VO4 0.494253 0.763158
111 SRP 0.494253 0.74359
112 VO4 ADP 0.494253 0.763158
113 2AM 0.493333 0.746667
114 26A 0.492958 0.867647
115 0UM 0.488889 0.810811
116 ADQ 0.488889 0.753247
117 LSS 0.488889 0.701149
118 DSZ 0.488889 0.678161
119 PAJ 0.488889 0.75
120 A1R 0.488889 0.725
121 3OD 0.483871 0.776316
122 62X 0.483516 0.815789
123 NVA LMS 0.483516 0.701149
124 AHX 0.483516 0.716049
125 A22 0.483146 0.763158
126 5CA 0.483146 0.678161
127 A3T 0.481928 0.880597
128 2VA 0.481928 0.855072
129 RP1 0.480519 0.75
130 SP1 0.480519 0.75
131 3L1 0.478873 0.8
132 3D1 0.478873 0.8
133 OAD 0.478261 0.776316
134 K15 0.478261 0.813333
135 LEU LMS 0.478261 0.701149
136 GEK 0.477778 0.833333
137 OOB 0.477778 0.763158
138 A3S 0.47561 0.84058
139 OVE 0.474359 0.74026
140 PR8 0.473118 0.698795
141 P5A 0.473118 0.648352
142 AMO 0.472527 0.74359
143 NSS 0.472527 0.678161
144 4AD 0.472527 0.734177
145 6MD 0.472222 0.893939
146 2FA 0.472222 0.816901
147 NOC 0.471429 0.791045
148 A2P 0.469136 0.756757
149 2BA 0.469136 0.767123
150 CMP 0.469136 0.777778
151 TXA 0.468085 0.766234
152 PTJ 0.468085 0.759494
153 1ZZ 0.468085 0.731707
154 QQX 0.467532 0.714286
155 00A 0.467391 0.725
156 DLL 0.467391 0.763158
157 5F1 0.465753 0.782609
158 MYR AMP 0.463158 0.731707
159 3UK 0.462366 0.753247
160 ADP BMA 0.462366 0.753247
161 ACK 0.461538 0.739726
162 QQY 0.461538 0.723684
163 GSU 0.457447 0.678161
164 A A 0.457447 0.773333
165 WAQ 0.457447 0.725
166 LAD 0.457447 0.707317
167 KAA 0.457447 0.655556
168 PPS 0.454545 0.698795
169 PAP 0.453488 0.76
170 NVA 2AD 0.453488 0.816901
171 NB8 0.452632 0.716049
172 JB6 0.452632 0.746835
173 FYA 0.452632 0.763158
174 BIS 0.452632 0.725
175 1DA 0.452055 0.878788
176 XAH 0.44898 0.690476
177 TYR AMP 0.44898 0.74359
178 VRT 0.448276 0.84507
179 SO8 0.448276 0.869565
180 25L 0.447917 0.763158
181 KB1 0.447917 0.786667
182 4UV 0.444444 0.734177
183 9SN 0.443299 0.716049
184 V3L 0.443182 0.773333
185 LAQ 0.441176 0.710843
186 7D3 0.439024 0.696203
187 ATP A A A 0.438776 0.783784
188 FA5 0.438776 0.74359
189 YAP 0.438776 0.734177
190 J1A 0.4375 0.740741
191 LPA AMP 0.436893 0.710843
192 J1C 0.435897 0.67033
193 AFH 0.435644 0.707317
194 7MD 0.435644 0.690476
195 4UU 0.435644 0.734177
196 J1B 0.434783 0.67033
197 YSA 0.434343 0.678161
198 TXD 0.432692 0.746835
199 4UW 0.432692 0.75
200 ARJ 0.432432 0.776119
201 MCF 0.432099 0.842857
202 KH3 0.431373 0.802632
203 TAD 0.431373 0.728395
204 GTA 0.431373 0.731707
205 4YB 0.431373 0.662921
206 AMP DBH 0.43 0.753247
207 IVH 0.428571 0.813333
208 AHZ 0.427184 0.731707
209 ARG AMP 0.427184 0.682353
210 3NZ 0.427083 0.833333
211 7C5 0.425743 0.773333
212 G3A 0.425743 0.716049
213 2A5 0.425287 0.708861
214 7MC 0.424528 0.694118
215 AP0 0.424528 0.7375
216 TT8 0.423913 0.898551
217 YLP 0.423077 0.694118
218 48N 0.423077 0.7375
219 CNA 0.422018 0.74359
220 AR6 AR6 0.421569 0.773333
221 G5P 0.421569 0.716049
222 ATR 0.420455 0.746667
223 101 0.419753 0.714286
224 D3Y 0.419355 0.816901
225 NXX 0.419048 0.74359
226 NAX 0.419048 0.698795
227 DND 0.419048 0.74359
228 6V0 0.419048 0.716049
229 NAI 0.419048 0.725
230 7D4 0.418605 0.696203
231 A A A 0.416667 0.763158
232 OMR 0.415094 0.722892
233 TXE 0.415094 0.725
234 649 0.415094 0.648352
235 D5M 0.414634 0.714286
236 DA 0.414634 0.714286
237 T5A 0.412844 0.694118
238 139 0.412844 0.698795
239 ADJ 0.412844 0.702381
240 YLB 0.411215 0.714286
241 YLC 0.411215 0.710843
242 J1D 0.410714 0.628866
243 AYB 0.409091 0.705882
244 A2R 0.408602 0.763158
245 A4P 0.407407 0.659091
246 UP5 0.40566 0.734177
247 NAD IBO 0.405405 0.75641
248 IOT 0.40367 0.666667
249 6CR 0.402597 0.805556
250 WSA 0.401869 0.686047
251 TYM 0.401869 0.74359
252 LA8 ALF 3PG 0.401869 0.707317
253 ALF ADP 3PG 0.401869 0.707317
254 AF3 ADP 3PG 0.401869 0.707317
255 4TA 0.401786 0.702381
256 YLA 0.4 0.674419
Ligand no: 2; Ligand: SAM; Similar ligands found: 192
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 XYA 0.565789 0.773333
9 ADN 0.565789 0.773333
10 RAB 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 AMP MG 0.511364 0.710843
25 5AL 0.510417 0.743902
26 VMS 0.510204 0.673913
27 54H 0.510204 0.673913
28 0UM 0.51 0.857143
29 A 0.505747 0.707317
30 AMP 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 DAL AMP 0.50505 0.765432
34 NVA LMS 0.504951 0.725275
35 K15 0.5 0.883117
36 6RE 0.5 0.78481
37 5AD 0.5 0.75
38 SSA 0.5 0.684783
39 SON 0.5 0.746988
40 SRP 0.5 0.746988
41 LSS 0.49505 0.706522
42 CA0 0.494624 0.714286
43 A12 0.494505 0.705882
44 AP2 0.494505 0.705882
45 ME8 0.490385 0.841463
46 5CA 0.49 0.684783
47 TSB 0.49 0.681319
48 53H 0.49 0.666667
49 ACP 0.489362 0.694118
50 5AS 0.48913 0.648936
51 ADP 0.48913 0.690476
52 A2D 0.488889 0.690476
53 J7C 0.488889 0.772152
54 ZAS 0.488636 0.769231
55 8QN 0.485149 0.743902
56 GAP 0.484536 0.73494
57 AN2 0.483871 0.682353
58 A3S 0.483871 0.813333
59 A7D 0.483871 0.851351
60 GJV 0.483516 0.775
61 SRA 0.483146 0.694118
62 LAD 0.480769 0.752941
63 KAA 0.480769 0.698925
64 GSU 0.480769 0.722222
65 AMO 0.480392 0.746988
66 DSZ 0.480392 0.703297
67 52H 0.48 0.666667
68 ADP MG 0.478723 0.702381
69 M33 0.478723 0.722892
70 MAO 0.478261 0.82716
71 BA3 0.478261 0.690476
72 AOC 0.477778 0.776316
73 DSH 0.477778 0.842105
74 NEC 0.477778 0.75
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 Y3J 0.47561 0.706667
78 G5A 0.474227 0.684783
79 A3T 0.473684 0.8
80 ADP BEF 0.473684 0.686047
81 BEF ADP 0.473684 0.686047
82 B4P 0.473118 0.690476
83 AP5 0.473118 0.690476
84 A3N 0.472527 0.766234
85 KB1 0.471698 0.833333
86 LEU LMS 0.471154 0.706522
87 APC 0.46875 0.705882
88 PRX 0.46875 0.73494
89 PAJ 0.466019 0.712644
90 4AD 0.466019 0.759036
91 RBY 0.463918 0.72619
92 ADP PO3 0.463918 0.728395
93 ADV 0.463918 0.72619
94 ADX 0.463158 0.666667
95 MHZ 0.463158 0.82716
96 AU1 0.463158 0.674419
97 YAP 0.462963 0.738095
98 TXA 0.462264 0.72619
99 NB8 0.462264 0.72093
100 A3G 0.461538 0.802632
101 VRT 0.459184 0.842105
102 ATP MG 0.459184 0.702381
103 YSA 0.458716 0.684783
104 XAH 0.458716 0.715909
105 50T 0.458333 0.682353
106 ATP 0.458333 0.690476
107 7D7 0.45679 0.723684
108 ANP MG 0.455446 0.678161
109 KH3 0.455357 0.871795
110 ACQ 0.454545 0.694118
111 AQP 0.453608 0.690476
112 5FA 0.453608 0.690476
113 AR6 0.453608 0.710843
114 APR 0.453608 0.710843
115 NSS 0.451923 0.703297
116 FA5 0.449541 0.746988
117 AGS 0.44898 0.678161
118 SAP 0.44898 0.678161
119 A5D 0.44898 0.789474
120 AD9 0.44898 0.674419
121 PTJ 0.448598 0.72093
122 YLB 0.448276 0.758621
123 YLP 0.447368 0.738636
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 TYR AMP 0.445455 0.746988
128 MYR AMP 0.444444 0.776471
129 3AM 0.444444 0.674699
130 OAD 0.443396 0.73494
131 2VA 0.443299 0.779221
132 OOB 0.442308 0.722892
133 S8M 0.442308 0.831169
134 ADP VO4 0.441176 0.702381
135 VO4 ADP 0.441176 0.702381
136 ANP 0.44 0.674419
137 TAT 0.44 0.686047
138 WAQ 0.439252 0.75
139 ARG AMP 0.438596 0.727273
140 YLC 0.435897 0.755814
141 AAT 0.435644 0.797468
142 3OD 0.435185 0.73494
143 1ZZ 0.435185 0.755814
144 NVA 2AD 0.434343 0.815789
145 DLL 0.433962 0.722892
146 00A 0.433962 0.689655
147 7MD 0.433628 0.715909
148 ATF 0.431373 0.666667
149 SO8 0.43 0.792208
150 3UK 0.429907 0.714286
151 A6D 0.429907 0.72619
152 5SV 0.428571 0.741176
153 AMP DBH 0.428571 0.714286
154 WSA 0.42735 0.692308
155 TYM 0.42735 0.746988
156 9SN 0.427273 0.681818
157 AHZ 0.426087 0.755814
158 A A 0.425926 0.710843
159 3NZ 0.425926 0.807692
160 P5A 0.425926 0.691489
161 PR8 0.425926 0.744186
162 A1R 0.424528 0.709302
163 2A5 0.424242 0.674419
164 7MC 0.423729 0.719101
165 7D5 0.422222 0.658824
166 FYA 0.422018 0.722892
167 JB6 0.422018 0.709302
168 AYB 0.421488 0.75
169 PLP AAD 0.419355 0.764045
170 A22 0.419048 0.682353
171 MAP 0.419048 0.659091
172 2AM 0.417582 0.666667
173 TAD 0.417391 0.712644
174 A3P 0.416667 0.686747
175 ADP BMA 0.416667 0.714286
176 25A 0.415094 0.690476
177 YLA 0.413223 0.719101
178 ADQ 0.411215 0.694118
179 48N 0.410256 0.72093
180 0XU 0.41 0.824324
181 NAD IBO 0.406504 0.717647
182 7D3 0.40625 0.643678
183 PAP 0.405941 0.678571
184 OVE 0.404255 0.662791
185 4UV 0.403509 0.697674
186 ALF ADP 3PG 0.403361 0.712644
187 AF3 ADP 3PG 0.403361 0.712644
188 LA8 ALF 3PG 0.403361 0.712644
189 3AD 0.402299 0.783784
190 CMP 0.402062 0.691358
191 2BA 0.402062 0.682927
192 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2YY8; Ligand: MTA; Similar sites found: 118
This union binding pocket(no: 1) in the query (biounit: 2yy8.bio1) has 17 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2UZI GTP 0.006698 0.42457 None
2 2C5L GTP 0.009536 0.41862 None
3 1XUJ BOZ 0.02461 0.42128 0.995025
4 5TP0 BRN 0.01329 0.4086 0.995025
5 3NK7 SAM 0.00004046 0.52281 1.49254
6 2WSI FAD 0.003583 0.43258 1.49254
7 1VJY 460 0.01319 0.41831 2.48756
8 1J17 ZEN 0.007618 0.40936 2.69058
9 3AB1 FAD 0.0245 0.41405 2.98507
10 3LZW FAD 0.03561 0.40386 2.98507
11 1PQ7 ARG 0.01177 0.40054 2.98507
12 2RGJ FAD 0.03385 0.40004 2.98507
13 4HA6 FAD 0.02588 0.41542 3.14961
14 1GJC 130 0.009585 0.42266 3.48259
15 4CNK FAD 0.03446 0.40459 3.48259
16 1I8T FAD 0.04029 0.402 3.48259
17 5L4S 6KX 0.03786 0.40156 3.48259
18 5L4S NAP 0.03786 0.40156 3.48259
19 1AE1 NAP 0.03339 0.40034 3.48259
20 1E96 GTP 0.01922 0.40235 3.64583
21 1N07 ADP 0.01451 0.40012 3.68098
22 1MXI SAH 0.000004909 0.5634 3.75
23 4JWF SAH 0.00002067 0.54359 3.9801
24 2Q7V FAD 0.01755 0.4224 3.9801
25 5FJN FAD 0.02771 0.41303 3.9801
26 5FJN BE2 0.03089 0.41303 3.9801
27 3GF4 FAD 0.04872 0.40828 3.9801
28 4GKV NAD 0.02566 0.40718 3.9801
29 2XTZ GSP 0.01798 0.4052 3.9801
30 4JWH SAH 0.00002316 0.54334 4.47761
31 1K97 CIR 0.01703 0.41928 4.47761
32 1K97 ASP 0.01703 0.41928 4.47761
33 2X2M X2M 0.00698 0.41879 4.47761
34 3K7M FAD 0.04157 0.41131 4.47761
35 3ICT FAD 0.02742 0.40874 4.47761
36 3ICS FAD 0.03691 0.40306 4.47761
37 2OQ2 A3P 0.01736 0.40302 4.47761
38 3ICR FAD 0.03626 0.40252 4.47761
39 4JAL SAH 0.000005318 0.56177 4.79042
40 1HDR NAD 0.03281 0.41395 4.97512
41 2WET FAD 0.03379 0.40771 4.97512
42 2QRK AMP 0.03911 0.40176 4.97512
43 3BBD SAH 0.000003515 0.56733 5.47264
44 3BBH SFG 0.0000003361 0.56124 5.47264
45 4CNE SAH 0.00002302 0.53185 5.47264
46 3UTU 1TS 0.00726 0.43361 5.47264
47 1EB1 ZAL PRO MMO 0.007923 0.42804 5.47264
48 1EFV FAD 0.03195 0.4194 5.47264
49 4O97 NTX 0.009268 0.41923 5.47264
50 1EFV AMP 0.0333 0.41845 5.47264
51 1SL3 170 0.008254 0.417 5.47264
52 5CEO 50D 0.005933 0.41649 5.47264
53 2E5V FAD 0.02667 0.41474 5.47264
54 5LMK 6ZK 0.005335 0.41436 5.47264
55 4K81 GTP 0.01462 0.40958 5.47264
56 1T90 NAD 0.0213 0.40793 5.47264
57 1D9I 00P 0.0166 0.40545 5.47264
58 3RK1 ATP 0.008382 0.40528 5.47264
59 1N4W FAD 0.04463 0.40307 5.47264
60 4E93 GUI 0.03026 0.40029 5.47264
61 3DDC GNP 0.01684 0.40658 5.52147
62 3O7B SAH 0.0000001069 0.64152 5.7377
63 1OIX GDP 0.006177 0.42627 5.75916
64 1P9P SAH 0.00000005826 0.66316 5.97015
65 4MCC 21X 0.00000133 0.60551 5.97015
66 5KGS 6SR 0.001691 0.47642 5.97015
67 1JGT APC 0.005959 0.43544 5.97015
68 1JGT CMA 0.005612 0.43544 5.97015
69 5L2Z 70C 0.01036 0.42703 5.97015
70 1KNR FAD 0.02023 0.41833 5.97015
71 5UIU 8CG 0.01428 0.41412 5.97015
72 3WGT QSC 0.03684 0.41129 5.97015
73 1I1N SAH 0.02075 0.40482 5.97015
74 2EC9 24X 0.01913 0.40246 5.97015
75 2H29 DND 0.01919 0.41134 6.34921
76 2P3T 993 0.004527 0.42592 6.46766
77 5H5F SAM 0.000003828 0.4828 6.96517
78 4BTI 7R9 0.005135 0.42332 6.96517
79 2VH6 GSV 0.006922 0.42067 6.96517
80 3AXB PRO 0.03265 0.40934 6.96517
81 3AXB FAD 0.02669 0.40934 6.96517
82 4J7U YTZ 0.03972 0.4049 6.96517
83 4J7U NAP 0.03972 0.4049 6.96517
84 5A7Y SAH 0.00004808 0.5198 7.46269
85 4NBU NAI 0.02087 0.40837 7.46269
86 1GTE FAD 0.03174 0.42145 7.9602
87 1NFU RRP 0.003342 0.42134 8.20513
88 2BNE U5P 0.006203 0.42123 8.45771
89 3G6K POP 0.006832 0.43122 8.95522
90 3G6K FAD 0.007673 0.43122 8.95522
91 1O94 AMP 0.006931 0.41528 8.95522
92 5J60 FAD 0.02621 0.41254 8.95522
93 1O97 AMP 0.04354 0.41155 8.95522
94 5W4W 9WG 0.02084 0.40065 8.95522
95 4RRG A3T 0.001897 0.40477 9.21986
96 1NVV GNP 0.005413 0.43058 9.45274
97 2XA2 UPG 0.008501 0.4147 9.45274
98 1Q19 APC 0.009794 0.41177 9.45274
99 1NVU GTP 0.0169 0.4065 9.45274
100 2QTR NXX 0.02534 0.40746 9.52381
101 1GUA GNP 0.008278 0.42162 9.58084
102 4CNG SAH 0.00007374 0.5229 9.95025
103 4JWJ SAH 0.00005578 0.52289 9.95025
104 1NAA ABL 0.02054 0.42759 10.4478
105 1NAA 6FA 0.01507 0.42759 10.4478
106 5MBX SP5 0.04041 0.41264 10.4478
107 5MBX FAD 0.04041 0.41264 10.4478
108 5TWJ SAM 0.0000006225 0.51052 12.3457
109 1MJH ATP 0.003069 0.43579 12.3457
110 4NBI D3Y 0.001982 0.44666 12.8049
111 3N7O N7O 0.01631 0.40727 12.9353
112 5JCA FAD 0.03809 0.40585 13.3803
113 1V2X SAM 0.0001005 0.50413 13.9175
114 3TWO NDP 0.03514 0.40128 14.4279
115 3GYQ SAM 0.000001123 0.59351 14.9254
116 5EYK 5U5 0.007621 0.42481 15.2542
117 1CT9 AMP 0.002997 0.41855 15.4229
118 4HDO GNP 0.009038 0.41976 23.8806
Pocket No.: 2; Query (leader) PDB : 2YY8; Ligand: SAM; Similar sites found: 46
This union binding pocket(no: 2) in the query (biounit: 2yy8.bio1) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1XUJ BOZ 0.0129 0.4191 0.995025
2 5TP0 BRN 0.02303 0.40585 0.995025
3 3NK7 SAM 0.00001221 0.51542 1.49254
4 2WSI FAD 0.002478 0.41974 1.49254
5 1GJC 130 0.005191 0.41691 3.48259
6 1MXI SAH 0.000001751 0.5428 3.75
7 4JWF SAH 0.000004604 0.5408 3.9801
8 4JWH SAH 0.000003951 0.54597 4.47761
9 3ITJ FAD 0.01742 0.41217 4.47761
10 2OQ2 A3P 0.0058 0.404 4.47761
11 4JAL SAH 0.000001436 0.54674 4.79042
12 2WET FAD 0.01434 0.41026 4.97512
13 3BBH SFG 0.00000007403 0.62509 5.47264
14 3BBD SAH 0.0000006364 0.55256 5.47264
15 4CNE SAH 0.00000744 0.51837 5.47264
16 3UTU 1TS 0.004439 0.42507 5.47264
17 1EB1 ZAL PRO MMO 0.003971 0.4234 5.47264
18 1N4W FAD 0.01416 0.41229 5.47264
19 4O97 NTX 0.006103 0.40954 5.47264
20 1EFV AMP 0.02585 0.40896 5.47264
21 1EFV FAD 0.02585 0.40896 5.47264
22 4MIG G3F 0.02817 0.40227 5.47264
23 3O7B SAH 0.0000002941 0.57523 5.7377
24 1P9P SAH 0.00000005865 0.61948 5.97015
25 4MCC 21X 0.0000006884 0.58117 5.97015
26 5KGS 6SR 0.005811 0.43028 5.97015
27 4UP3 FAD 0.01427 0.40943 5.97015
28 1JGT APC 0.01052 0.40586 5.97015
29 1JGT CMA 0.009864 0.40586 5.97015
30 5H5F SAM 0.000002212 0.52622 6.96517
31 2JLD AG1 0.00869 0.41078 6.96517
32 4I6H 1C8 0.008962 0.40071 6.96517
33 5A7Y SAH 0.00001319 0.56127 7.46269
34 3G6K POP 0.002651 0.43118 8.95522
35 3G6K FAD 0.00318 0.43032 8.95522
36 4RRG A3T 0.002543 0.42105 9.21986
37 4CNG SAH 0.000007899 0.53719 9.95025
38 4JWJ SAH 0.000008922 0.52844 9.95025
39 1NAA 6FA 0.02363 0.40191 10.4478
40 1NAA ABL 0.03288 0.40191 10.4478
41 5TWJ SAM 0.0000002514 0.56437 12.3457
42 4NBI D3Y 0.003948 0.41289 12.8049
43 1V2X SAM 0.0000528 0.48854 13.9175
44 3GYQ SAM 0.000003818 0.52945 14.9254
45 1COY FAD 0.008477 0.42082 17.4129
46 5TVA AMP 0.01743 0.40192 24.8756
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