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Receptor
PDB id Resolution Class Description Source Keywords
2YD6 1.35 Å EC: 3.1.3.48 CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-2 MODULE OF HUMAN RE PROTEIN TYROSINE PHOSPHATASE DELTA HOMO SAPIENS HYDROLASE
Ref.: PROTEOGLYCAN-SPECIFIC MOLECULAR SWITCH FOR RPTP SIG CLUSTERING AND NEURONAL EXTENSION. SCIENCE V. 332 484 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:1222;
Invalid;
none;
submit data
35.453 Cl [Cl-]
FLC A:1223;
Valid;
none;
submit data
189.1 C6 H5 O7 C(C(=...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2YD6 1.35 Å EC: 3.1.3.48 CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-2 MODULE OF HUMAN RE PROTEIN TYROSINE PHOSPHATASE DELTA HOMO SAPIENS HYDROLASE
Ref.: PROTEOGLYCAN-SPECIFIC MOLECULAR SWITCH FOR RPTP SIG CLUSTERING AND NEURONAL EXTENSION. SCIENCE V. 332 484 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 28 families.
1 2YD6 - FLC C6 H5 O7 C(C(=O)[O-....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 26 families.
1 2YD6 - FLC C6 H5 O7 C(C(=O)[O-....
2 2YD8 - SCR C12 H22 O35 S8 C([C@@H]1[....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 2YD1 - GLY C2 H5 N O2 C(C(=O)O)N
2 2YD6 - FLC C6 H5 O7 C(C(=O)[O-....
3 2YD8 - SCR C12 H22 O35 S8 C([C@@H]1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FLC; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 FLC 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2YD6; Ligand: FLC; Similar sites found with APoc: 13
This union binding pocket(no: 1) in the query (biounit: 2yd6.bio1) has 5 residues
No: Leader PDB Ligand Sequence Similarity
1 3DUV KDO 3.77358
2 2PO3 T4K 3.77358
3 4LY9 S6P 3.77358
4 4LY9 1YY 3.77358
5 1Q9I TEO 3.85289
6 1Q9I FAD 3.85289
7 6AM8 PLT 4.24528
8 6CUZ FEV 4.24528
9 5VN0 NAI 4.71698
10 5V8E CIT 6.13208
11 3MBI ADP 6.60377
12 2D7I UDP 7.54717
13 6EWR PMP 7.54717
Pocket No.: 2; Query (leader) PDB : 2YD6; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2yd6.bio1) has 5 residues
No: Leader PDB Ligand Sequence Similarity
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