-->
Receptor
PDB id Resolution Class Description Source Keywords
2XOC 1.89 Å EC: 6.3.2.- C-TERMINAL CYSTEINE-RICH DOMAIN OF HUMAN CHFR BOUND TO MADPR HOMO SAPIENS ZINC-BINDING LIGASE POLY(ADP-RIBOSE) MITOSIS ANTEPHASE CHECKPOINT CELL CYCLE
Ref.: STRUCTURAL BASIS OF POLY(ADP-RIBOSE) RECOGNITION BY THE MULTIZINC BINDING DOMAIN OF CHECKPOINT WITH FORKHEAD-ASSOCIATED AND RING DOMAINS (CHFR). J.BIOL.CHEM. V. 285 39348 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ADE B:1664;
B:1665;
Valid;
Valid;
none;
none;
submit data
135.127 C5 H5 N5 c1[nH...
ADP A:1665;
Valid;
none;
submit data
427.201 C10 H15 N5 O10 P2 c1nc(...
PGE A:1664;
Invalid;
none;
submit data
150.173 C6 H14 O4 C(COC...
ZN A:991;
A:992;
A:993;
A:994;
A:995;
B:991;
B:992;
B:993;
B:994;
B:995;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2XOC 1.89 Å EC: 6.3.2.- C-TERMINAL CYSTEINE-RICH DOMAIN OF HUMAN CHFR BOUND TO MADPR HOMO SAPIENS ZINC-BINDING LIGASE POLY(ADP-RIBOSE) MITOSIS ANTEPHASE CHECKPOINT CELL CYCLE
Ref.: STRUCTURAL BASIS OF POLY(ADP-RIBOSE) RECOGNITION BY THE MULTIZINC BINDING DOMAIN OF CHECKPOINT WITH FORKHEAD-ASSOCIATED AND RING DOMAINS (CHFR). J.BIOL.CHEM. V. 285 39348 2010
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 36 families.
1 2XOZ - AMP C10 H14 N5 O7 P c1nc(c2c(n....
2 2XOC - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 24 families.
1 2XOZ - AMP C10 H14 N5 O7 P c1nc(c2c(n....
2 2XOC - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 19 families.
1 2XOZ - AMP C10 H14 N5 O7 P c1nc(c2c(n....
2 2XOC - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ADE; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 ADE 1 1
2 PM6 0.5 0.742857
3 ES4 0.463415 0.685714
4 6AP 0.428571 0.9375
5 XQG 0.422222 0.648649
6 M02 0.411765 0.630435
Ligand no: 2; Ligand: ADP; Similar ligands found: 452
No: Ligand ECFP6 Tc MDL keys Tc
1 ADP 1 1
2 HEJ 0.9 1
3 ATP 0.9 1
4 A2D 0.895522 0.971831
5 5FA 0.887324 1
6 AQP 0.887324 1
7 AP5 0.884058 0.971831
8 B4P 0.884058 0.971831
9 BA3 0.869565 0.971831
10 AN2 0.84507 0.985915
11 AT4 0.84507 0.958904
12 M33 0.833333 0.958333
13 ACQ 0.826667 0.972222
14 A 0.823529 0.971429
15 AMP 0.823529 0.971429
16 ACP 0.821918 0.972222
17 6YZ 0.818182 0.972222
18 APR 0.810811 0.971831
19 AR6 0.810811 0.971831
20 ANP 0.802632 0.972222
21 SAP 0.8 0.945946
22 AGS 0.8 0.945946
23 AD9 0.8 0.972222
24 ADX 0.783784 0.873418
25 CA0 0.783784 0.945205
26 TAT 0.779221 0.958904
27 T99 0.779221 0.958904
28 50T 0.773333 0.958333
29 ABM 0.763889 0.917808
30 APC 0.763158 0.958904
31 PRX 0.763158 0.893333
32 ATF 0.759494 0.958904
33 A22 0.753086 0.985915
34 AP2 0.743243 0.958904
35 A12 0.743243 0.958904
36 SRA 0.736111 0.918919
37 ADQ 0.73494 0.945205
38 25L 0.732558 0.985915
39 5AL 0.725 0.931507
40 2A5 0.717949 0.918919
41 A1R 0.714286 0.907895
42 AU1 0.714286 0.972222
43 A3R 0.714286 0.907895
44 ATR 0.708861 0.971429
45 ADP PO3 0.708861 0.943662
46 PAP 0.708861 0.985714
47 SRP 0.707317 0.906667
48 7D3 0.706667 0.905405
49 25A 0.702381 0.971831
50 9X8 0.697674 0.92
51 OAD 0.697674 0.945205
52 RBY 0.6875 0.932432
53 ADV 0.6875 0.932432
54 00A 0.686047 0.883117
55 OOB 0.682353 0.931507
56 5SV 0.682353 0.848101
57 8QN 0.682353 0.931507
58 3OD 0.681818 0.945205
59 BIS 0.681818 0.933333
60 ALF ADP 0.674699 0.87013
61 ADP ALF 0.674699 0.87013
62 AMO 0.674419 0.932432
63 4AD 0.674419 0.92
64 PAJ 0.674419 0.884615
65 GAP 0.670732 0.893333
66 MAP 0.670588 0.945946
67 AHX 0.666667 0.896104
68 VO4 ADP 0.666667 0.931507
69 DLL 0.666667 0.931507
70 ADP VO4 0.666667 0.931507
71 PTJ 0.662921 0.896104
72 3UK 0.659091 0.918919
73 SON 0.658228 0.932432
74 LMS 0.653333 0.82716
75 LAD 0.651685 0.860759
76 WAQ 0.651685 0.883117
77 B5V 0.651685 0.906667
78 PR8 0.651685 0.85
79 ITT 0.65 0.943662
80 7D4 0.65 0.905405
81 G5P 0.648936 0.921053
82 XYA 0.647059 0.84507
83 ADN 0.647059 0.84507
84 RAB 0.647059 0.84507
85 1ZZ 0.644444 0.839506
86 ME8 0.644444 0.839506
87 FYA 0.644444 0.905405
88 NB8 0.644444 0.896104
89 TXA 0.644444 0.932432
90 6AD 0.642857 0.909091
91 ADP BMA 0.640449 0.918919
92 G3A 0.638298 0.921053
93 DAL AMP 0.632184 0.905405
94 AFH 0.631579 0.884615
95 9SN 0.630435 0.871795
96 9ZA 0.625 0.907895
97 DQV 0.625 0.958333
98 9ZD 0.625 0.907895
99 GTA 0.625 0.886076
100 YAP 0.623656 0.894737
101 B5M 0.623656 0.894737
102 FA5 0.623656 0.906667
103 B5Y 0.623656 0.894737
104 UP5 0.622449 0.92
105 HFD 0.619048 0.945946
106 XAH 0.617021 0.839506
107 AV2 0.616279 0.917808
108 AOC 0.615385 0.821918
109 48N 0.612245 0.896104
110 4UV 0.610526 0.894737
111 6V0 0.606061 0.896104
112 NAI 0.606061 0.907895
113 DND 0.606061 0.932432
114 NAX 0.606061 0.873418
115 NXX 0.606061 0.932432
116 TXD 0.606061 0.907895
117 5N5 0.605634 0.819444
118 5AS 0.604938 0.77907
119 A4P 0.60396 0.843373
120 DAT 0.60241 0.905405
121 A2R 0.602273 0.985915
122 TXE 0.6 0.907895
123 OMR 0.6 0.851852
124 4UU 0.597938 0.894737
125 GA7 0.597938 0.906667
126 A A 0.597826 0.944444
127 A4D 0.597222 0.819444
128 5CD 0.597222 0.805556
129 AP0 0.594059 0.896104
130 4TC 0.594059 0.896104
131 A3P 0.592593 0.971429
132 T5A 0.592233 0.841463
133 139 0.592233 0.873418
134 7D5 0.592105 0.878378
135 ATP A A A 0.589474 0.930556
136 LAQ 0.585859 0.839506
137 MYR AMP 0.585106 0.817073
138 F2R 0.580952 0.864198
139 YLP 0.58 0.819277
140 UPA 0.578431 0.907895
141 7DD 0.578313 0.985714
142 3AM 0.576923 0.929577
143 ADJ 0.576923 0.851852
144 COD 0.575472 0.811765
145 NAD 0.575472 0.931507
146 3AT 0.574713 0.971831
147 JB6 0.574468 0.883117
148 4UW 0.574257 0.860759
149 EP4 0.573333 0.753247
150 A2P 0.573171 0.957143
151 CNA 0.571429 0.932432
152 TYM 0.568627 0.906667
153 PPS 0.568182 0.873418
154 DTA 0.565789 0.786667
155 M2T 0.565789 0.734177
156 AR6 AR6 0.565657 0.917808
157 A3D 0.564815 0.918919
158 80F 0.564815 0.841463
159 3DH 0.564103 0.773333
160 G5A 0.563218 0.77907
161 YLB 0.563107 0.819277
162 YLC 0.563107 0.839506
163 AMP DBH 0.561224 0.893333
164 TYR AMP 0.561224 0.87013
165 MTA 0.558442 0.773333
166 DTP 0.556818 0.905405
167 AHZ 0.554455 0.817073
168 NA7 0.553191 0.958904
169 IOT 0.552381 0.831325
170 ZAS 0.55 0.766234
171 7MD 0.55 0.8625
172 ARG AMP 0.55 0.829268
173 IMO 0.548781 0.929577
174 YLA 0.54717 0.819277
175 NAE 0.544643 0.894737
176 TAD 0.544554 0.884615
177 A5A 0.544444 0.807229
178 2AM 0.544304 0.943662
179 TSB 0.543478 0.819277
180 6RE 0.54321 0.759494
181 AYB 0.542056 0.809524
182 NAQ 0.539823 0.871795
183 V3L 0.539326 0.971831
184 SSA 0.538462 0.8
185 AF3 ADP 3PG 0.538462 0.8375
186 ZID 0.535088 0.918919
187 LPA AMP 0.533981 0.817073
188 52H 0.532609 0.77907
189 VMS 0.532609 0.788235
190 54H 0.532609 0.788235
191 BTX 0.53211 0.841463
192 A3N 0.53012 0.786667
193 J7C 0.53012 0.769231
194 5X8 0.528736 0.763158
195 BT5 0.527273 0.831325
196 8X1 0.526882 0.752809
197 5CA 0.526882 0.8
198 53H 0.526882 0.77907
199 ARU 0.526316 0.860759
200 EAD 0.525862 0.873418
201 RGT 0.525253 0.958904
202 OVE 0.52439 0.905405
203 S4M 0.52381 0.666667
204 7DT 0.522727 0.985714
205 GDP 0.522222 0.92
206 DDS 0.522222 0.878378
207 AVV 0.521277 0.896104
208 NDE 0.521008 0.932432
209 7MC 0.518868 0.841463
210 DSH 0.518072 0.725
211 MAO 0.517647 0.759036
212 NSS 0.515789 0.8
213 DSZ 0.515789 0.8
214 LSS 0.515789 0.761364
215 P5A 0.515464 0.744444
216 DZD 0.513514 0.884615
217 NVA LMS 0.510417 0.752809
218 9K8 0.510204 0.714286
219 12D 0.509615 0.785714
220 M24 0.508772 0.85
221 YLY 0.508772 0.809524
222 P1H 0.508333 0.851852
223 5AD 0.506849 0.746479
224 GJV 0.505882 0.75
225 LEU LMS 0.505155 0.752809
226 AMP NAD 0.504505 0.905405
227 4TA 0.504505 0.807229
228 G A A A 0.504505 0.871795
229 NAJ PZO 0.504425 0.848101
230 GSU 0.5 0.77907
231 128 0.5 0.776471
232 KAA 0.5 0.752809
233 71V 0.5 0.907895
234 A3G 0.5 0.8
235 NDC 0.5 0.871795
236 7D7 0.5 0.743243
237 N0B 0.495726 0.819277
238 NJP 0.495495 0.945946
239 ODP 0.495495 0.909091
240 2SA 0.494624 0.932432
241 6C6 0.494505 0.881579
242 SFG 0.494382 0.75
243 0WD 0.491071 0.921053
244 YSA 0.490196 0.77907
245 PO4 PO4 A A A A PO4 0.489796 0.902778
246 SAM 0.48913 0.690476
247 6IA 0.48913 0.8375
248 A7D 0.488636 0.776316
249 6FA 0.488 0.841463
250 FB0 0.487805 0.804598
251 NAJ PYZ 0.487179 0.807229
252 A5D 0.483516 0.786667
253 IDP 0.483516 0.918919
254 SA8 0.483516 0.707317
255 PGS 0.483146 0.883117
256 MHZ 0.483146 0.697674
257 DA 0.482353 0.878378
258 D5M 0.482353 0.878378
259 NEC 0.482353 0.746667
260 NIA 0.481928 0.822785
261 Y3J 0.480519 0.726027
262 8PZ 0.480392 0.8
263 FAD 0.480315 0.851852
264 FAS 0.480315 0.851852
265 FDA 0.48 0.833333
266 N6P 0.479592 0.915493
267 GGZ 0.479167 0.825
268 U A 0.478261 0.907895
269 SAH 0.478261 0.74359
270 SAI 0.478261 0.734177
271 A G 0.477876 0.883117
272 NPW 0.477477 0.886076
273 NDP 0.477477 0.921053
274 AAM 0.476744 0.971429
275 C2R 0.47561 0.90411
276 AMZ 0.47561 0.916667
277 A A A 0.474747 0.905405
278 GTP 0.473684 0.92
279 U A G G 0.473684 0.883117
280 SMM 0.473684 0.686047
281 NZQ 0.473214 0.909091
282 TXP 0.473214 0.921053
283 A3S 0.47191 0.810811
284 SFD 0.46875 0.734043
285 AIR 0.468354 0.901408
286 AAT 0.468085 0.707317
287 EEM 0.468085 0.690476
288 J7V 0.466667 0.833333
289 Z5A 0.466667 0.77907
290 7C5 0.466667 0.818182
291 62F 0.465649 0.8625
292 HDV 0.463158 0.893333
293 FAY 0.462121 0.8625
294 A3T 0.461538 0.821918
295 ETB 0.461538 0.833333
296 DCA 0.461538 0.823529
297 A6D 0.46 0.722892
298 A U 0.459459 0.87013
299 GEK 0.459184 0.7375
300 6K6 0.459184 0.930556
301 RFL 0.458647 0.821429
302 NAP 0.458333 0.945205
303 S7M 0.458333 0.690476
304 4YB 0.457944 0.761364
305 WSA 0.454545 0.788235
306 TAP 0.454545 0.907895
307 FNK 0.454545 0.804598
308 COA 0.453782 0.823529
309 0T1 0.453782 0.823529
310 101 0.453488 0.878378
311 XNP 0.452174 0.873418
312 NA0 0.45082 0.932432
313 7RP 0.448276 0.928571
314 GP3 0.446809 0.921053
315 TM1 0.446602 0.77381
316 APU 0.446429 0.894737
317 PUA 0.445378 0.884615
318 V1N 0.443396 0.917808
319 7RA 0.443182 0.957747
320 COS 0.442623 0.804598
321 AMX 0.442623 0.833333
322 30N 0.442623 0.752688
323 CAO 0.442623 0.795455
324 QQY 0.44186 0.815789
325 ACK 0.44186 0.861111
326 649 0.441441 0.744444
327 0UM 0.44 0.698795
328 NHD 0.439655 0.905405
329 CMX 0.439024 0.823529
330 SCO 0.439024 0.823529
331 GCP 0.438776 0.896104
332 8BR 0.438202 0.906667
333 GNH 0.4375 0.907895
334 8Q2 0.4375 0.772727
335 3AD 0.4375 0.805556
336 NVA 2AD 0.43617 0.759494
337 62X 0.435644 0.666667
338 FCX 0.435484 0.795455
339 ACO 0.435484 0.795455
340 FAM 0.435484 0.804598
341 9JJ 0.434783 0.8625
342 GNP 0.434343 0.896104
343 9GM 0.434343 0.896104
344 NMX 0.433071 0.76087
345 MGP 0.43299 0.884615
346 26A 0.432099 0.763158
347 HAX 0.432 0.804598
348 K15 0.431373 0.682353
349 DG1 0.430894 0.921053
350 1DG 0.430894 0.921053
351 QQX 0.430233 0.805195
352 2VA 0.430108 0.8
353 S8M 0.43 0.759494
354 2MC 0.429688 0.769231
355 6G0 0.428571 0.884615
356 P5F 0.428571 0.823529
357 FYN 0.428571 0.823529
358 3KK 0.428571 0.804598
359 A C A C 0.428571 0.848101
360 7L1 0.427419 0.795455
361 FAI 0.426966 0.916667
362 RMB 0.426966 0.873239
363 AS 0.426966 0.833333
364 1RB 0.425287 0.885714
365 CA6 0.425197 0.729167
366 SOP 0.425197 0.804598
367 OXK 0.425197 0.804598
368 MCD 0.425197 0.804598
369 COK 0.425197 0.804598
370 G1R 0.424242 0.907895
371 SXZ 0.423077 0.710843
372 CC5 0.423077 0.816901
373 F2N 0.422535 0.813953
374 EO7 0.422222 0.788235
375 ANZ 0.422018 0.8
376 1VU 0.421875 0.795455
377 CMC 0.421875 0.804598
378 CO6 0.421875 0.804598
379 ZDA 0.421053 0.864865
380 GKE 0.420561 0.884615
381 GDC 0.420561 0.884615
382 GDD 0.420561 0.884615
383 NFD 0.420168 0.883117
384 GSP 0.42 0.873418
385 D3Y 0.42 0.789474
386 MC4 0.419847 0.76087
387 3D1 0.419753 0.773333
388 3L1 0.419753 0.773333
389 FA9 0.41958 0.864198
390 5GP 0.419355 0.906667
391 G 0.419355 0.906667
392 KB1 0.419048 0.698795
393 CAJ 0.418605 0.804598
394 SCD 0.418605 0.823529
395 CMP 0.417582 0.901408
396 2BA 0.417582 0.915493
397 SO8 0.416667 0.789474
398 VRT 0.416667 0.769231
399 N01 0.416667 0.905405
400 IVC 0.415385 0.813953
401 1HE 0.415385 0.786517
402 A1S 0.415385 0.804598
403 BCO 0.415385 0.804598
404 3HC 0.415385 0.813953
405 MLC 0.415385 0.804598
406 NMN AMP PO4 0.415254 0.87013
407 2FA 0.414634 0.813333
408 MGO 0.414141 0.860759
409 3NZ 0.413462 0.782051
410 COO 0.412214 0.804598
411 MCA 0.412214 0.795455
412 YE1 0.412214 0.813953
413 CAA 0.412214 0.813953
414 GAV 0.411765 0.884615
415 PRT 0.411215 0.931507
416 JLN 0.411111 0.890411
417 P2P 0.411111 0.902778
418 ZZB 0.410256 0.77381
419 SP1 0.409091 0.842105
420 RP1 0.409091 0.842105
421 2CP 0.409091 0.795455
422 SCA 0.409091 0.804598
423 103 0.409091 0.837838
424 PAX 0.408 0.829268
425 FAD NBT 0.407143 0.75
426 COW 0.406015 0.795455
427 3CP 0.406015 0.804598
428 IRC 0.406015 0.813953
429 BYC 0.406015 0.804598
430 CA8 0.406015 0.729167
431 1GZ 0.406015 0.795455
432 COF 0.406015 0.786517
433 HGG 0.406015 0.804598
434 2KQ 0.406015 0.786517
435 G2P 0.405941 0.884615
436 SLU 0.404959 0.770115
437 U A C C 0.404959 0.858974
438 RBZ 0.404494 0.849315
439 1CZ 0.404412 0.795455
440 FAQ 0.402985 0.804598
441 BCA 0.402985 0.795455
442 4CA 0.402985 0.795455
443 MTP 0.402439 0.730769
444 8OD 0.402062 0.945205
445 CO7 0.401515 0.804598
446 GRA 0.4 0.804598
447 G2R 0.4 0.884615
448 ENQ 0.4 0.916667
449 CNV FAD 0.4 0.8
450 GMV 0.4 0.896104
451 HXC 0.4 0.786517
452 HF7 0.4 0.893333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2XOC; Ligand: ADE; Similar sites found with APoc: 178
This union binding pocket(no: 1) in the query (biounit: 2xoc.bio2) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 4LTN NAI None
2 4LTN FMN None
3 2AG5 NAD None
4 4IAE 1DX None
5 3CB0 FMN None
6 2QZT PLM None
7 5LQ8 GB 1.14943
8 5O96 SAM 1.22449
9 1DSS NAD 1.53257
10 1VCO GLN 1.53257
11 4RDI ATP 1.53257
12 4RDH AMP 1.53257
13 4B5W PYR 1.5625
14 2DJH 3PD UM3 1.73913
15 5E9W SAH 1.91571
16 1QO8 FAD 1.91571
17 4ZEV M6P 1.91571
18 4YT4 FE9 1.91571
19 6BSW UDP 1.91571
20 3T34 GDP 1.91571
21 5Z21 NAI 1.91571
22 5JCZ GDP 1.91571
23 5LD5 NAD 1.91571
24 4CS9 AMP 2.1164
25 5U6C 7YS 2.22222
26 2B4R AES 2.29885
27 3V1Y NAD 2.29885
28 2B4R NAD 2.29885
29 2VYN NAD 2.29885
30 4AT0 FAD 2.29885
31 3CGB FAD 2.29885
32 1DL5 SAH 2.29885
33 5TVJ COA 2.29885
34 5TVJ 7LF 2.29885
35 5UXH GFB 2.29885
36 6AOV SIA GAL NAG GAL NAG 2.29885
37 3TFJ THG 2.29885
38 1E5Q NDP 2.29885
39 3IQE H4M 2.29885
40 4BTV RB3 2.29885
41 1FLJ GSH 2.30769
42 1S7G NAD 2.37154
43 1KDO C 2.64317
44 1Z82 G3P 2.68199
45 1Z82 G3H 2.68199
46 3TWO NDP 2.68199
47 4UP3 FAD 2.68199
48 4RJK TDL 2.68199
49 5TTJ FAD 2.68199
50 4EJN 0R4 2.68199
51 5MR6 FAD 2.68199
52 2GV8 FAD 2.68199
53 4MKF AP5 2.76498
54 3BNK FMN 3.06122
55 3CIF G3H 3.06513
56 3CIF NAD 3.06513
57 6A0S NDP 3.06513
58 6A0S HSE 3.06513
59 1ZXM ANP 3.06513
60 4DO1 ANN 3.06513
61 5EOB 5QQ 3.06513
62 4O4K 2PK 3.06513
63 2VZ0 NAP 3.06513
64 2VZ0 D64 3.06513
65 5H81 NAP 3.06513
66 6FAA ADP 3.06513
67 3EPO MP5 3.06513
68 4KP7 1UQ 3.06513
69 4KP7 NAP 3.06513
70 5EYG NAP 3.06513
71 1ZIN AP5 3.22581
72 1SQS TLA 3.30579
73 2OYS FMN 3.30579
74 5HRA DAS 3.40426
75 3HY3 10F 3.44828
76 5AYV NAP 3.44828
77 6F7L FAD 3.44828
78 5YAP 8S0 3.44828
79 5YAP NAI 3.44828
80 4OCJ NDG 3.44828
81 1F5N GNP 3.44828
82 5IRR GSP 3.44828
83 2JFN GLU 3.44828
84 5MEX SZZ 3.44828
85 5KOK S9T 3.44828
86 2DFV NAD 3.44828
87 5T9F TYR 3.44828
88 5T9F NAP 3.44828
89 2CJF RP4 3.82166
90 1RSG FAD 3.83142
91 2DBZ NAP 3.83142
92 4N8I COA 3.83142
93 1RM6 PCD 3.83142
94 1YQZ FAD 3.83142
95 3D91 REM 3.83142
96 3TM0 B31 3.83142
97 3TM0 ANP 3.83142
98 2HQM FAD 3.83142
99 1A8R GTP 4.0724
100 1ELI PYC 4.21456
101 1V59 FAD 4.21456
102 1U8X NAD 4.21456
103 3S5W FAD 4.21456
104 2Q4H AMP 4.21456
105 4ITR GDP 4.21456
106 4XO8 KGM 4.43038
107 4C0X AQN 4.4335
108 4C0X FMN 4.4335
109 5BUK FAD 4.5977
110 2RGJ FAD 4.5977
111 5WGR FAD 4.5977
112 4D79 ATP 4.5977
113 1K3T BRZ 4.5977
114 2IHU TP9 4.5977
115 4IDN GNP 4.5977
116 2IVD FAD 4.98084
117 1HKU NAD 4.98084
118 2A8X FAD 4.98084
119 4G8R 96P 4.98084
120 4AGS GSH 4.98084
121 2PEL LBT 5.08475
122 2PEL LAT 5.08475
123 2QRD ADP 5.15464
124 4GKV NAD 5.36398
125 2BHZ MAL 5.36398
126 1Q5H DUD 5.44218
127 5UR0 NAD 5.74713
128 5THY SAH 5.74713
129 5THZ SAH 5.74713
130 3DLS ADP 5.74713
131 3C0G 3AM 5.74713
132 5V22 SAH 5.74713
133 2Z9C FMN 6
134 2Z9C DTC 6
135 1J0X NAD 6.13027
136 5IH9 6BF 6.13027
137 2GZM DGL 6.13027
138 4EOY ASN ASP TRP LEU LEU PRO SER TYR 6.25
139 1T5B FMN 6.46766
140 3H9E NAD 6.51341
141 4ZGS NAD 6.51341
142 1Q20 A3P 6.51341
143 1Q20 PLO 6.51341
144 4EUU BX7 6.51341
145 1CF2 NAP 6.51341
146 4N65 AQN 6.60377
147 4N65 FMN 6.60377
148 4U36 TNR 6.66667
149 4H4D 10E 6.89655
150 1Z6T ADP 6.89655
151 4ASE AV9 6.89655
152 1LLU NAD 7.27969
153 3ZY6 GFB 7.27969
154 1D09 PAL 7.84314
155 2B4Q NAP 8.42912
156 5Z2L NDP 8.57143
157 4NU0 AP5 8.75576
158 5K4W NAI 8.81226
159 6C1S EFV 9.1954
160 2NAD NAD 9.1954
161 3LAD FAD 9.1954
162 3TA2 AKG 9.32203
163 4WNP 3RJ 9.7561
164 3T6E UQ9 9.96169
165 2JB2 FAD 9.96169
166 1YVD GNP 10.0592
167 1WUR 8DG 10.9091
168 3MQG U5P 10.9375
169 1VLH PNS 10.9827
170 4ZVF GAV 11.0465
171 4X9M FAD 11.8774
172 1EK0 GNP 12.9412
173 1BWO LPC 13.3333
174 2RAB FAD 13.7931
175 2GSD NAD 14.9425
176 4M5S GLY GLU ARG THR ILE PRO ILE THR ARG GLU 14.9425
177 2XB8 XNW 19.1781
178 5N1Z 8GQ 26.0163
Pocket No.: 2; Query (leader) PDB : 2XOC; Ligand: ADE; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2xoc.bio2) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2XOC; Ligand: ADP; Similar sites found with APoc: 505
This union binding pocket(no: 3) in the query (biounit: 2xoc.bio1) has 7 residues
No: Leader PDB Ligand Sequence Similarity
1 1UNQ 4IP None
2 1JYQ MAZ PTR PTM ASN None
3 5KK4 44E None
4 4CQK PIO None
5 1SQL GUN None
6 2UX9 COA None
7 4IZY 1J2 0.766284
8 2IF8 ADP 1.14943
9 5A6N U7E 1.14943
10 4XH0 ADP 1.53257
11 5ZTN CUR 1.53257
12 4U0I 0LI 1.53257
13 5Y86 HRM 1.53257
14 3E7O 35F 1.53257
15 4UX9 ANP 1.53257
16 3NGL NAP 1.53257
17 4PXL NAD 1.53257
18 4F4P 0SB 1.53257
19 5XVG 8FX 1.53257
20 1ZX5 LFR 1.53257
21 4NFE BEN 1.68776
22 2BW7 APC 1.82648
23 5MZI FAD 1.91571
24 5MZI FYK 1.91571
25 4G17 0VN 1.91571
26 4ZCC NAI 1.91571
27 2YW2 ATP 1.91571
28 3ALN ANP 1.91571
29 3BU5 ATP 1.91571
30 3EKK GS2 1.91571
31 1IR3 ANP 1.91571
32 1K3A ACP 1.91571
33 3NW7 LGV 1.91571
34 3OZV ECN 1.91571
35 2O3Z AI7 1.91571
36 5HVJ ANP 1.91571
37 4RDL FUC GAL NDG FUC 1.91571
38 4WW8 VD9 1.91571
39 3FW3 ETS 1.91571
40 5CJF 520 1.91571
41 3OZV FAD 1.91571
42 2ZL7 FUC GAL NGA 1.91571
43 3BZ3 YAM 1.91571
44 5BW4 SAM 1.91571
45 3AB4 THR 1.91571
46 6BSW CE6 1.91571
47 6BSW UDP 1.91571
48 5WO4 B7V 1.91571
49 4WUP 3UF 1.92308
50 6FE1 V14 1.94553
51 4FE2 ADP 1.96078
52 1R1Q ACE ARG GLU PTR VAL ASN VAL 2
53 4CS9 AMP 2.1164
54 4YNM SAM 2.21239
55 2QK4 ATP 2.29885
56 6GZD LCI 2.29885
57 4NZN 2OU 2.29885
58 4NZN ANP 2.29885
59 2Q7D ANP 2.29885
60 1M0W ANP 2.29885
61 2B9F ADP 2.29885
62 4PU5 ANP 2.29885
63 3DLG GWE 2.29885
64 5VC5 96M 2.29885
65 2PID YSA 2.29885
66 2B9I ADP 2.29885
67 5GXU FAD 2.29885
68 4N70 2HX 2.29885
69 5AX9 4KT 2.29885
70 2B9J ADP 2.29885
71 3ZQ6 ADP ALF 2.29885
72 2B9H ADP 2.29885
73 1KQN NAD 2.29885
74 5L2M 6ZY 2.29885
75 4E1Z 0MX 2.29885
76 4DQL NAP 2.29885
77 4DQL FAD 2.29885
78 1W3Y PVC 2.29885
79 4AT0 FAD 2.29885
80 4B7H NDP 2.29885
81 4BTV RB3 2.29885
82 5WP4 SAH 2.29885
83 4K33 ACP 2.29885
84 5JKG 6LF 2.29885
85 3TII ANP 2.29885
86 1Y8Q ATP 2.29885
87 3L8W XAN 2.29885
88 6A1G 9OL 2.29885
89 4B4U NAP 2.29885
90 5WS9 AMP 2.29885
91 4U44 3D9 2.29885
92 5NMX NAP 2.29885
93 5NMX FAD 2.29885
94 2FES 3SP 2.3166
95 1S7G NAD 2.37154
96 3I53 SAH 2.40964
97 4O4F IHP 2.41935
98 4O4F ATP 2.41935
99 1DMY AZM 2.41935
100 1RSD PSB 2.47934
101 4XBA 5GP 2.5
102 4XBA GMP 2.5
103 2GQR ADP 2.53165
104 1KDO C 2.64317
105 4TM3 FAD 2.68199
106 1W2D 4IP 2.68199
107 1W2D ADP 2.68199
108 3KN5 ANP 2.68199
109 5TA6 79D 2.68199
110 3FC2 IBI 2.68199
111 5KO1 6UY 2.68199
112 6BXI ANP 2.68199
113 4A4Z ANP 2.68199
114 4ZDC CO8 2.68199
115 2Z4T C5P 2.68199
116 4C2W ANP 2.68199
117 4C2V YJA 2.68199
118 5TO8 7FM 2.68199
119 3UA1 08Y 2.68199
120 5ENZ UDP 2.68199
121 3FSY SCA 2.68199
122 1H6W SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 2.68199
123 2WOX NDP 2.68199
124 1Z82 NDP 2.68199
125 3V4S ATP 2.68199
126 1HMU ASG GCD 2.68199
127 5EXT ADP 2.69231
128 3RE4 TO1 2.71318
129 1GS5 NLG 2.71318
130 1GS5 ANP 2.71318
131 4IRP UDP 2.78884
132 4N9I PCG 2.85714
133 1IM8 SAI 2.86885
134 2GQS ADP 2.95359
135 4LRJ ANP 2.95858
136 4ELG 52I 3.01205
137 4ELG 52J 3.01205
138 6FL8 TIY 3.06513
139 6FL8 ADP 3.06513
140 3FHR P4O 3.06513
141 3GC8 B45 3.06513
142 3VOT ADP 3.06513
143 3HZT J60 3.06513
144 5VCV 1N1 3.06513
145 2Y6O 1N1 3.06513
146 1TZD ADP 3.06513
147 3QO8 SSA 3.06513
148 6ES0 BW8 3.06513
149 5NKB 8ZT 3.06513
150 6CGD GNP 3.06513
151 6CGD AKN 3.06513
152 3UDZ ADP 3.06513
153 4CM9 YGL 3.06513
154 5EXK 5AD 3.06513
155 4CYI ATP 3.06513
156 1XF1 CIT 3.06513
157 1MUU GDX 3.06513
158 1MV8 GDX 3.06513
159 4F97 VDO 3.06513
160 4ZS4 ATP 3.06513
161 3BP1 GUN 3.06513
162 4CMI M4V 3.06513
163 4COQ SAN 3.23887
164 4IPH 1FJ 3.25203
165 1YBU APC 3.26087
166 5A9A UTP 3.29218
167 3N1S 5GP 3.36134
168 5HRA DAS 3.40426
169 6A5K SAM 3.44828
170 5COU ATP 3.44828
171 4MV1 ADP 3.44828
172 2IHK CSF 3.44828
173 5AWM ANP 3.44828
174 2RIO ADP 3.44828
175 2XK9 XK9 3.44828
176 5UPK ANP 3.44828
177 5USZ SKE 3.44828
178 2R7K AMZ 3.44828
179 2R7K ACP 3.44828
180 2PUL ACP 3.44828
181 2HGS ADP 3.44828
182 3GQI ACP 3.44828
183 3SWG EPZ 3.44828
184 4EWH T77 3.44828
185 4XB2 NDP 3.44828
186 4XB2 HSE 3.44828
187 5N87 N66 3.44828
188 5FA5 MTA 3.44828
189 3TY3 GGG 3.44828
190 3GFB NAD 3.44828
191 4BNU 9KQ 3.44828
192 5JZJ AN2 3.44828
193 5EY0 GTP 3.44828
194 2EFJ SAH 3.44828
195 5G1X ADP 3.44828
196 3E5A VX6 3.44828
197 4L8F MTX 3.44828
198 5Y0T TAT 3.44828
199 2EG5 SAH 3.44828
200 1F6D UDP 3.44828
201 5NKN LOC 3.44828
202 3HMO STU 3.44828
203 5EH0 5NW 3.48837
204 1PK8 ATP 3.5545
205 3VX3 ADP 3.62903
206 4K4D HFQ 3.64964
207 1JG3 ADN 3.82979
208 6AC9 ANP 3.83142
209 4H3Q ANP 3.83142
210 4UAL 3FV 3.83142
211 5FHD ADP ALF 3.83142
212 2YK7 CSF 3.83142
213 4OAV ACP 3.83142
214 8CAT NDP 3.83142
215 5I35 ANP 3.83142
216 5I60 67W 3.83142
217 1DY4 SNP 3.83142
218 5C4L 4XR 3.83142
219 4UBT COA 3.83142
220 5DXT 5H5 3.83142
221 4DFU QUE 3.83142
222 1GQ2 NAP 3.83142
223 6E2O S0L 3.83142
224 1I9G SAM 3.83142
225 4O1P ANP 3.83142
226 3R35 4CO 3.97351
227 2CB3 MLD 4
228 3MYZ TFX 4
229 1A8R GTP 4.0724
230 2Q4H AMP 4.21456
231 5FAL SKT 4.21456
232 5FAL COA 4.21456
233 6GBC AMP 4.21456
234 5TT5 NAD 4.21456
235 5BV3 M7G 4.21456
236 4CC6 L5Y 4.21456
237 2AQX ATP 4.21456
238 2H8H H8H 4.21456
239 1T90 NAD 4.21456
240 1T36 ADP 4.21456
241 4YZN 4K5 4.21456
242 2YAB AMP 4.21456
243 6CZ3 FLJ 4.21456
244 1Y57 MPZ 4.21456
245 5ZI2 NAD 4.21456
246 1OBD ATP 4.21456
247 5H2U 1N1 4.21456
248 4V3C C 4.21456
249 2WQN ADP 4.21456
250 5AVF TAU 4.28016
251 5RHN 8BR 4.34783
252 5FA8 SAM 4.34783
253 4PZ6 GMP 4.5977
254 4GYI ADP 4.5977
255 4GJ3 0XP 4.5977
256 4B63 ORN 4.5977
257 4B63 NAP 4.5977
258 4B63 FAD 4.5977
259 2VZ6 FEF 4.5977
260 2V7O DRN 4.5977
261 5OES ADP 4.5977
262 3SXS PP2 4.5977
263 4NFN 2KC 4.5977
264 4BTK DTQ 4.5977
265 2CSN CKI 4.5977
266 3VRY B43 4.5977
267 2VN9 GVD 4.5977
268 5VYH FOL 4.5977
269 4RPL 3UC 4.5977
270 4RPL FAD 4.5977
271 1OPK P16 4.5977
272 2HK5 1BM 4.5977
273 3ETH ATP 4.5977
274 1PN4 HDC 4.5977
275 4I94 ANP 4.5977
276 6BOX SAH 4.5977
277 3KMW ATP 4.65116
278 4AZW ATP 4.67091
279 4YGF AZM 4.70085
280 4GV8 DUP 4.73373
281 6E8I PTR 4.73373
282 1NB9 ADP 4.7619
283 1NB9 RBF 4.7619
284 3UG4 AHR 4.96032
285 2GK6 ADP 4.98084
286 4Z3X MTE 4.98084
287 3PN1 IVH 4.98084
288 6EZ6 C5Z 4.98084
289 4R84 CSF 4.98084
290 5TZJ UD1 4.98084
291 4Z3X 4KX 4.98084
292 4NDO ATP 4.98084
293 3BEO UDP 4.98084
294 1UP7 NAD 4.98084
295 1AUX AGS 4.98084
296 3M2W L8I 4.98084
297 4JMO JAF 5
298 5EYK 5U5 5.08475
299 1LCK GLU GLY GLN PTR GLN PRO GLN PRO ALA 5.14286
300 1S68 AMP 5.22088
301 4WW7 AMP 5.34759
302 1F9A ATP 5.35714
303 5HCY 60D 5.36398
304 4K39 SAM 5.36398
305 3VSV XYS 5.36398
306 3KAL ADP 5.36398
307 4K37 SAM 5.36398
308 4K38 SAM 5.36398
309 5FI4 5XV 5.36398
310 5TDF ADP 5.36398
311 2FB3 MET 5.36398
312 3T7V SAM 5.36398
313 4IDT T28 5.36398
314 5FUB SAH 5.36398
315 3QWB NDP 5.36398
316 2J6U DGT 5.36398
317 4I3V NAD 5.36398
318 5DEY 59T 5.36398
319 5OGX FAD 5.36398
320 5WA9 9ZD 5.42636
321 3R5Z F42 5.51724
322 1P1C SAH 5.52764
323 1AV5 AP2 5.55556
324 4X5S AZM 5.60345
325 5F1H 5U6 5.69106
326 4Y8D 49J 5.71429
327 5UMY TNN 5.71429
328 4C5N PXL 5.74713
329 1GNI OLA 5.74713
330 5JLB SAH 5.74713
331 4QTB 38Z 5.74713
332 4A4X JUP 5.74713
333 3DLS ADP 5.74713
334 4C5N ACP 5.74713
335 2VQD AP2 5.74713
336 4PTN PYR 5.74713
337 4KS7 X4Z 5.74713
338 1BYG STU 5.74713
339 1EHI ADP 5.74713
340 5V22 SAH 5.74713
341 3C0G 3AM 5.74713
342 4JSR 1NQ 5.74713
343 1GP6 QUE 5.74713
344 1GP6 DH2 5.74713
345 1GP6 SIN 5.74713
346 1PFY MSP 5.74713
347 3W0O HY0 5.74713
348 3W0O ADP 5.74713
349 1XCL SAH 5.95745
350 2PAR TMP 5.97015
351 5NBW 8SK 6.07477
352 4XYM A12 6.08696
353 4NJH SAM 6.08696
354 4NJH 2K8 6.08696
355 4XZ3 ACP 6.08696
356 5BVE 4VG 6.13027
357 4H3P ANP 6.13027
358 6C8R EQV 6.13027
359 6C8R SAH 6.13027
360 3DAK ANP 6.13027
361 6CMJ F6J 6.13027
362 5BO9 SIA GAL NGS 6.13027
363 3SRV S19 6.13027
364 5HPZ 68G 6.14525
365 4INI AMP 6.15385
366 2A5F GTP 6.21762
367 1Q3P GLU ALA GLN THR ARG LEU 6.42202
368 2DM6 NAP 6.51341
369 2DM6 IMN 6.51341
370 5C3R AKG 6.51341
371 5C3R HMU 6.51341
372 4UXL 5P8 6.51341
373 2Z7R STU 6.51341
374 2YAK OSV 6.51341
375 4DI8 0GZ 6.51341
376 4DI8 0GY 6.51341
377 3ZS7 ATP 6.51341
378 4I8P NAD 6.51341
379 1SG4 CO8 6.53846
380 4ZRB COA 6.56934
381 4G7A AZM 6.85484
382 2QTR NXX 6.87831
383 3TPV ADE 6.89655
384 2D4V NAD 6.89655
385 2IMP NAI 6.89655
386 3VHE 42Q 6.89655
387 4ASE AV9 6.89655
388 3DNT ATP 6.89655
389 3KH5 ADP 6.89655
390 4NW6 2NS 6.89655
391 5FBN 5WF 6.89655
392 2H8Z 8CM 6.89655
393 2H8Z FMN 6.89655
394 4AG8 AXI 6.89655
395 2X2M X2M 6.89655
396 4LWP SAH 6.89655
397 3BGD SAH 6.92308
398 3BGD PM6 6.92308
399 3R5J ACE ALA ASP VAL ALA ASA 7.14286
400 6CZ7 MGD 7.27969
401 5MW8 ATP 7.27969
402 4TWP AXI 7.27969
403 4CLI 5P8 7.27969
404 3TY5 ADP 7.27969
405 2F57 23D 7.27969
406 2Y5D NAP 7.49064
407 1ZEI CRS 7.54717
408 4CTA ATP 7.66284
409 3X01 AMP 7.66284
410 4FL3 ANP 7.66284
411 5JGA 6KC 7.66284
412 1I7L ATP 7.66284
413 5DBX ANP 7.66284
414 4I9B NAD 7.66284
415 2F2U M77 7.66284
416 3KV8 FAH 7.91367
417 2WEL K88 8
418 5T8O 76Z 8.04598
419 3AKK ADP 8.04598
420 5L13 6ZE 8.04598
421 5VZ0 ADP 8.04598
422 1G9J BGC SGC BGC SGC BGC SGC BGC SGC 8.04598
423 4A0M NAD 8.04598
424 5IBE 69M 8.04598
425 2R5T ANP 8.04598
426 4I4Z 2NE 8.04598
427 1UPR 4IP 8.13008
428 2A0S BIO 8.33333
429 1CKM GTP 8.42912
430 4DVR 0LY 8.42912
431 4E93 GUI 8.42912
432 4CQE CQE 8.42912
433 3HAV ATP 8.42912
434 4LH7 1X8 8.42912
435 3TKI S25 8.42912
436 2VSU ACO 8.42912
437 4YMJ 4EJ 8.42912
438 4XV1 904 8.42912
439 5XLY C2E 8.42912
440 2VSS ACO 8.42912
441 4QMN DB8 8.42912
442 5XLX SAH 8.42912
443 4KOT CE3 8.64198
444 3BL7 DD1 8.81226
445 1ST0 GTG 8.81226
446 4I54 1C1 8.81226
447 3WO0 ALA 8.81226
448 3WO0 ADP 8.81226
449 4Y0X ADP 8.81226
450 4AT3 LTI 8.81226
451 1S1D GP2 8.81226
452 2J4K U5P 8.84956
453 2QHD DAO 9.01639
454 6C1S EFV 9.1954
455 1Q8Y ADE 9.1954
456 5DBV COA 9.1954
457 3SLS ANP 9.1954
458 2PZI AXX 9.1954
459 1EP2 FAD 9.1954
460 5FDZ 5X0 9.2437
461 5L8L ADP 9.40171
462 2ZWI C5P 9.57854
463 1XJD STU 9.57854
464 4WNP 3RJ 9.7561
465 2WAT COA 9.83607
466 2WME NAP 9.96169
467 4HVA 4HV 9.96169
468 1NBU PH2 10.084
469 1IA9 ANP 10.3448
470 4Q5H ANP 10.5263
471 4JGP PYR 10.5991
472 3H0L ADP 10.728
473 4DC2 ADE 10.728
474 1WUR 8DG 10.9091
475 1VLH PNS 10.9827
476 1O44 852 11.1111
477 6GWR FEW 11.1111
478 3G5D 1N1 11.1111
479 5O1I 9GH 11.4155
480 4Z4P SAH 11.4458
481 3VCY UD1 11.4943
482 5LXT ACP 11.8881
483 5ERR ADP 12.2605
484 3V8S 0HD 12.2605
485 3PP0 03Q 12.6437
486 1JPA ANP 12.6437
487 3RIY NAD 13.0268
488 1BWO LPC 13.3333
489 4RT1 C2E 13.3929
490 5L0U 660 13.41
491 2ISJ FMN 13.4783
492 4LWA Q13 13.7931
493 4EIL CB3 14.1762
494 1U2Z SAH 14.1762
495 5Y80 IRE 14.1892
496 1AJ8 COA 14.5594
497 5DZT AMP 14.5594
498 3VPB ADP 16.092
499 3VPC ADP 16.092
500 4LI4 AMP 16.9118
501 4AU8 Z3R 17.2414
502 2J7T 274 18.0077
503 5OKT 9XK 22.9885
504 5MT9 SRO 23.8095
505 2PVF ACP 46.6667
APoc FAQ
Feedback