Receptor
PDB id Resolution Class Description Source Keywords
2WU6 1.92 Å EC: 2.7.12.1 CRYSTAL STRUCTURE OF THE HUMAN CLK3 IN COMPLEX WITH DKI HOMO SAPIENS TRANSFERASE KINASE TYROSINE-PROTEIN KINASE SERINE/THREONINE-PROTEIN KINASE NUCLEOTIDE-BINDING
Ref.: SPECIFIC CLK INHIBITORS FROM A NOVEL CHEMOTYPE FOR REGULATION OF ALTERNATIVE SPLICING. CHEM.BIOL V. 18 67 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:1495;
A:1496;
A:1497;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
35.453 Cl [Cl-]
DKI A:1484;
Valid;
none;
ic50 = 29.2 nM
425.436 C15 H13 F2 N7 O2 S2 c1cc(...
DMS A:1488;
A:1489;
A:1490;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
78.133 C2 H6 O S CS(=O...
EDO A:1491;
A:1492;
A:1493;
A:1494;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
SO4 A:1485;
A:1486;
A:1487;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WU6 1.92 Å EC: 2.7.12.1 CRYSTAL STRUCTURE OF THE HUMAN CLK3 IN COMPLEX WITH DKI HOMO SAPIENS TRANSFERASE KINASE TYROSINE-PROTEIN KINASE SERINE/THREONINE-PROTEIN KINASE NUCLEOTIDE-BINDING
Ref.: SPECIFIC CLK INHIBITORS FROM A NOVEL CHEMOTYPE FOR REGULATION OF ALTERNATIVE SPLICING. CHEM.BIOL V. 18 67 2011
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2WU7 ic50 = 530 nM V25 C15 H13 Cl2 N3 O2 CCOC(=O)c1....
2 2WU6 ic50 = 29.2 nM DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2WU7 ic50 = 530 nM V25 C15 H13 Cl2 N3 O2 CCOC(=O)c1....
2 2WU6 ic50 = 29.2 nM DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2WU7 ic50 = 530 nM V25 C15 H13 Cl2 N3 O2 CCOC(=O)c1....
2 2WU6 ic50 = 29.2 nM DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
3 2VAG ic50 = 19.7 nM V25 C15 H13 Cl2 N3 O2 CCOC(=O)c1....
4 5X8I ic50 = 2 nM SQZ C24 H16 F N5 O C[C@@H](c1....
5 1Z57 - DBQ C11 H11 N5 O2 c1c[nH]c2c....
6 5J1W ic50 = 0.19 uM 6FB C11 H8 N4 c1cncc2c1c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: DKI; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 DKI 1 1
2 SKE 0.6 0.9
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2WU6; Ligand: DKI; Similar sites found: 371
This union binding pocket(no: 1) in the query (biounit: 2wu6.bio1) has 24 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2YW2 ATP 0.001145 0.43591 1.31234
2 3DNT ATP 0.001728 0.42287 1.31234
3 3TPV ADE 0.008521 0.40176 1.31234
4 1IA9 ANP 0.00005731 0.49673 1.42857
5 5MW8 ATP 0.000008879 0.51519 1.5748
6 4AXD ANP 0.00004653 0.50841 1.5748
7 3UDZ ADP 0.00001245 0.49344 1.5748
8 2PUL ACP 0.000007261 0.48667 1.5748
9 5MRH Q9Z 0.002402 0.45264 1.5748
10 3K5I ADP 0.001863 0.42686 1.73697
11 1E4E ADP 0.002348 0.40542 2.04082
12 5I35 ANP 0.0000002592 0.61481 2.09974
13 1Q8A HCS 0.002962 0.45436 2.09974
14 4RDL FUC GAL NDG FUC 0.008196 0.43298 2.27273
15 4I94 ANP 0.0000003185 0.53454 2.33333
16 4U98 ACP 0.000152 0.48852 2.3622
17 2G50 PYR 0.01468 0.41783 2.3622
18 4PU5 ANP 0.002454 0.41482 2.3622
19 4OCJ NDG 0.0001252 0.48967 2.37467
20 4OCV ANP 0.00007208 0.46402 2.37467
21 3ZJX BOG 0.0005635 0.49434 2.42215
22 5C1P ADP 0.002599 0.40249 2.61438
23 2PYW ADP 0.00004406 0.47654 2.62467
24 2VQD AP2 0.0001857 0.45201 2.62467
25 3ETH ATP 0.0005972 0.43593 2.8169
26 4JD3 PLM 0.01684 0.40328 2.83286
27 4JD3 COA 0.0161 0.40328 2.83286
28 1EHI ADP 0.001318 0.41464 2.91777
29 3I0O ADP 0.000007127 0.45958 2.94985
30 1IOW PHY 0.002377 0.4303 3.14961
31 4AZW ATP 0.0002448 0.44737 3.41207
32 4AZT LY2 0.0002095 0.42473 3.41207
33 4XYM A12 0.0004066 0.43224 3.47826
34 5GZ9 ANP 0.0000001156 0.59268 3.60656
35 5VZ0 ADP 0.0003181 0.42818 3.67454
36 3WO0 ALA 0.006091 0.41607 3.67454
37 5T96 79J 0.02124 0.41179 3.80117
38 1TQP ATP 0.000002343 0.54142 3.90071
39 4OAV ACP 0.00000001278 0.58543 4.19948
40 5IQD RIO 0.00002104 0.52343 4.2623
41 5IQD GNP 0.00001944 0.52343 4.2623
42 4XMF HSM 0.0002108 0.55311 4.34783
43 5C03 AGS 0.000001023 0.58016 4.38596
44 2IO8 ADP 0.0001202 0.47074 4.46194
45 1EWF PC1 0.007166 0.4161 4.46194
46 3WVR AMP 0.0004638 0.41594 4.46194
47 5H4I 7HQ 0.01594 0.41694 4.49438
48 5W2I I3P 0.001247 0.42872 4.66926
49 5W2I ADP 0.001247 0.42872 4.66926
50 2VPQ ANP 0.0002763 0.45383 4.72441
51 5NCY 8TK 0.0001864 0.4247 4.72441
52 1M0W ANP 0.001464 0.40074 4.72441
53 4WOV 3SM 0.00000045 0.62075 4.73186
54 3SJK LYS PRO VAL LEU ARG THR ALA 0.01589 0.42264 4.73684
55 4O4F ATP 0.001207 0.41257 4.83871
56 4O4F IHP 0.001324 0.40675 4.83871
57 3VPC ADP 0.0001012 0.4667 4.96454
58 4O1P ANP 0.00000000105 0.63462 4.98688
59 3RE4 TO1 0.00000733 0.46599 5.03876
60 2IF8 ADP 0.0001259 0.40679 5.23416
61 3X01 AMP 0.0001279 0.52497 5.24934
62 4DFU QUE 0.004229 0.44546 5.2795
63 5JDA AMP 0.007875 0.42756 5.29248
64 5C4L 4XR 0.00009737 0.48544 5.29595
65 5C4L SIS 0.0001491 0.47756 5.29595
66 3VPD ANP 0.0009968 0.42719 5.33808
67 3Q60 ATP 0.000006039 0.49093 5.39084
68 5GZZ GSH 0.01946 0.40409 5.50459
69 4GYI ADP 0.000009903 0.55662 5.51181
70 3V4S ATP 0.002691 0.40972 5.51181
71 3V4S ADP 0.01211 0.40085 5.51181
72 4ZS4 ATP 0.00001529 0.5218 5.53746
73 3TDV GDP 0.000009321 0.48676 5.55556
74 4LO2 GAL BGC 0.02123 0.41028 5.74324
75 1I7L ATP 0.0001252 0.47 5.82524
76 3ORQ ADP 0.000532 0.45016 5.83554
77 3AKK ADP 0.0002173 0.44653 5.84615
78 3W0O ADP 0.0002346 0.46759 6.01719
79 3W0O HY0 0.0002346 0.42192 6.01719
80 3PDT ADP 0.00005939 0.45487 6.18182
81 3KMW ATP 0.00000698 0.49024 6.20155
82 5FCF GLY GLY GLY 0.006371 0.42587 6.56168
83 4R78 AMP 0.000003669 0.59401 6.79612
84 5FI4 5XV 0.001568 0.42461 6.81115
85 4L2I NAD 0.008031 0.4186 6.84411
86 4L2I FAD 0.01318 0.40034 6.84411
87 3GNI ATP 0.000000102 0.60921 7.08661
88 4WW7 AMP 0.00002071 0.49507 7.08661
89 5TDF ADP 0.002987 0.40409 7.08661
90 4C5N ACP 0.005372 0.41379 7.24638
91 4C5N PXL 0.005732 0.41379 7.24638
92 4CYI ATP 0.00002497 0.48854 7.34908
93 1Z45 GAL 0.005385 0.44004 7.61155
94 5H9O GLC 0.02814 0.40533 7.95455
95 1T36 ADP 0.002472 0.42127 8.13648
96 4UWH JXM 0.002365 0.43844 8.15308
97 2BKK ADP 0.0003012 0.41968 8.71212
98 5KO1 6UY 0.0000000169 0.6689 8.83392
99 4LRJ ANP 0.000003616 0.49674 8.87574
100 5MX4 HPA 0.007497 0.43223 9.01288
101 2HGS ADP 0.001365 0.4253 9.18635
102 4ANW O92 0.00008397 0.48981 9.71129
103 1ZP9 ATP 0.000001342 0.50567 10.0775
104 1ZTH ADP 0.000000416 0.50205 10.0775
105 3VOT ADP 0.0005333 0.4067 10.2362
106 1S9D AFB 0.0218 0.40041 10.3659
107 1YRO UDP 0.04357 0.40127 10.8392
108 4YEE 4CQ 0.03249 0.4011 11.1111
109 4CC6 L5Y 0.006037 0.43252 11.3208
110 3H9R TAK 0.0000004203 0.49645 11.5152
111 1GSA ADP 0.00001268 0.50883 11.7089
112 1PK8 ATP 0.0001364 0.47042 11.811
113 4OUC 5ID 0.00000002208 0.57369 12.3249
114 2QLU ADE 0.000007207 0.58746 12.4204
115 5CKW ANP 0.00000125 0.48757 12.5984
116 3VHE 42Q 0.00000004495 0.62516 12.8134
117 4Y85 499 0.000002571 0.50442 12.9518
118 4E93 GUI 0.000000001194 0.69704 12.9973
119 4YZN 4K5 0.000000001207 0.67411 13.2404
120 4Q5H ANP 0.000005033 0.54929 13.4615
121 4BKJ STI 0.00005353 0.48731 13.6508
122 1W2D ADP 0.0001981 0.41823 13.9623
123 1W2D 4IP 0.004012 0.41389 13.9623
124 1AUX AGS 0.00005047 0.50461 14.4695
125 4ZGP ADP 0.001777 0.43979 14.6758
126 5K2M ADP 0.000118 0.47107 15.0943
127 2OO8 RAJ 0.0001357 0.46099 15.142
128 4FL3 ANP 0.000000006445 0.65218 15.2756
129 3LQV ADE 0.01498 0.41589 15.3846
130 3ORK AGS 0.0000001962 0.58855 15.4341
131 3UIM ANP 0.00000001005 0.59893 15.4856
132 5M06 ADP 0.0000008543 0.59909 15.5797
133 1XJD STU 0.000000002739 0.68547 15.6522
134 5DBX ANP 0.0000002009 0.52135 15.8537
135 4XH0 ADP 0.000000978 0.63744 16.0105
136 5LXT ACP 0.003379 0.4091 16.0105
137 4G17 0VN 0.0000003938 0.52527 16.9697
138 4G31 0WH 0.000008227 0.44884 17.0569
139 2Y6O 1N1 0.0000003963 0.56298 17.5258
140 5CEO 50D 0.000001246 0.5226 19
141 5DRB 5FJ 0.000001531 0.42713 19.244
142 5W4W 9WG 0.00000002603 0.63756 19.6375
143 4KBA 1QM 0.0000004917 0.53054 19.6375
144 3VPB ADP 0.00002517 0.48199 19.6429
145 4L9I 8PR 0.000001182 0.58474 22.0472
146 5VC5 96M 0.000000001186 0.68661 22.1453
147 4YZC STU 0.00000002592 0.64831 22.3097
148 4P5Z Q7M 0.00000009778 0.48916 22.4377
149 4JDI ANP 0.00000008003 0.58427 22.8324
150 3VRY B43 0.0000002064 0.56072 23.3596
151 3KRL KRL 0.0000005141 0.55894 23.5821
152 5DMZ ADP 0.0000001661 0.61541 23.8845
153 5UKL SIX 0.0000008672 0.56636 24.147
154 3PVW QRX 0.0000009038 0.53096 24.147
155 3PP0 03Q 0.0000001964 0.55153 24.5562
156 2CSN CKI 0.0000000001517 0.72105 24.5791
157 4OH4 ANP 0.0000000007592 0.71983 24.6246
158 4Y93 746 0.000000057 0.58287 24.6719
159 5LPZ ADP 0.000000000708 0.72118 24.6988
160 3HAV ATP 0.005079 0.40663 24.7492
161 4WNK 453 0.0000001609 0.60169 24.9344
162 4UAL 3FV 0.00000006078 0.57564 24.9344
163 3V8S 0HD 0.00000003872 0.56673 24.9344
164 5HCY 60D 0.000000003398 0.69842 25.0755
165 2F2U M77 0.00000006558 0.67089 25.1968
166 4U0I 0LI 0.00001636 0.51842 25.7143
167 1Y57 MPZ 0.00000008414 0.59835 25.9843
168 2H8H H8H 0.00000001701 0.59088 25.9843
169 3C1X CKK 0.00001457 0.50021 26.0054
170 5VCV 1N1 0.00000000000239 0.76614 26.045
171 5LI1 ANP 0.00000001581 0.62006 26.2712
172 4Y8D 49J 0.00000001942 0.65701 26.4706
173 2XVD AS6 0.00000001053 0.64938 26.4901
174 5LI9 ACP 0.0000002319 0.60126 26.5714
175 4ASE AV9 0.000001107 0.5619 26.6289
176 5JGA 6KC 0.0000001149 0.52129 26.6667
177 4U44 3D9 0.00000009681 0.56603 26.8072
178 1O9U ADZ 0.000000621 0.64278 26.8571
179 3TXO 07U 0.000000004412 0.59319 26.9122
180 2PVF ACP 0.00000000233 0.61292 26.9461
181 5HVJ ANP 0.0000000389 0.7168 26.9841
182 3F7Z 34O 0.00000004937 0.57745 27.1429
183 5MJA 7O3 0.0000001084 0.54025 27.2131
184 3DAK ANP 0.00000001294 0.57431 27.2414
185 2X4Z X4Z 0.0000004846 0.58941 27.3649
186 5NKB 8ZT 0.00000008753 0.47525 27.451
187 2R5T ANP 0.0000002865 0.56965 27.6139
188 5LPB ADP 0.000000000268 0.60351 27.7027
189 4OTH DRN 0.000000001033 0.68553 27.8592
190 3LXN MI1 0.00000003057 0.60071 27.9874
191 2WQN ADP 0.000001604 0.59438 28.0645
192 4WB7 ATP 0.0000003924 0.48297 28.084
193 4IDT T28 0.00000001197 0.5897 28.0899
194 4M69 ANP 0.0000003696 0.55874 28.115
195 2YAB AMP 0.0000003934 0.55191 28.2548
196 5T8O 76Z 0.00000002398 0.6361 28.6533
197 3KRR DQX 0.00000003114 0.67987 28.8136
198 4E1Z 0MX 0.0000003096 0.5751 28.866
199 2JDR L20 0.00000005694 0.42237 28.9474
200 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.00000005694 0.42237 28.9474
201 3RI1 3RH 0.00000004728 0.61687 29.0735
202 2A19 ANP 0.0000001245 0.65727 29.2254
203 3DLS ADP 0.00000003082 0.56214 29.2537
204 4AT3 LTI 0.0000002733 0.52014 29.4314
205 4GJ3 0XP 0.00000003924 0.62997 29.4702
206 4YMJ 4EJ 0.000000009412 0.74549 29.6053
207 4DC2 ADE 0.0000001583 0.46599 29.6588
208 4AG8 AXI 0.0000005644 0.47961 29.7468
209 5EOB 5QQ 0.0000003906 0.61963 29.7806
210 4N70 2HX 0.000000008834 0.68677 29.878
211 2X2M X2M 0.00000009893 0.58833 29.9363
212 1U59 STU 0.000000002734 0.62466 29.9652
213 5HES 032 0.00000202 0.53495 29.9674
214 4CSV STI 0.00001163 0.51037 30.1818
215 2PZI AXX 0.00003317 0.53154 30.1837
216 5AX9 4KT 0.00000002793 0.58581 30.1948
217 1OPK P16 0.000003023 0.47947 30.4462
218 4K33 ACP 0.00000002764 0.59469 30.4615
219 3GGF GVD 0.000000001884 0.60604 30.5648
220 1RE8 BD2 0.0000000427 0.65296 30.5714
221 2QCS ANP 0.00000005315 0.61474 30.5714
222 3FHI ANP 0.00000006008 0.61252 30.5714
223 3IDB ANP 0.00000004447 0.60973 30.5714
224 3ALN ANP 0.000000005186 0.6297 30.581
225 1U5R ATP 0.000000001898 0.61645 30.7471
226 4WB6 ATP 0.00000006776 0.61034 30.8571
227 3PLS ANP 0.0000000007831 0.62957 30.8725
228 4USF 6UI 0.000001532 0.54905 30.9211
229 4FF8 14S 0.00001059 0.45806 30.9598
230 3LXK MI1 0.0000002986 0.5858 31.1927
231 4Y0X ADP 0.0000008783 0.52011 31.2
232 3CY2 MB9 0.000000005758 0.64622 31.2102
233 4EWH T77 0.00000002168 0.57949 31.2727
234 1VJY 460 0.00000001492 0.65015 31.3531
235 1ZY5 ANP 0.000004789 0.49244 31.3531
236 1K3A ACP 0.00000001345 0.56325 31.4381
237 5USZ SKE 0.00000004908 0.5664 31.4879
238 5JFS 6K0 0.000000005511 0.68353 31.4935
239 3TKI S25 0.000000002064 0.72156 31.5789
240 1BYG STU 0.00000005056 0.56037 31.6547
241 2HY0 306 0.00000002881 0.67778 31.677
242 2GU8 796 0.000000009256 0.69492 31.7507
243 2F57 23D 0.0000002086 0.53661 31.8612
244 3SLS ANP 0.000000005146 0.65628 31.9079
245 5JKG 6LF 0.000003455 0.55764 32.1543
246 3NW7 LGV 0.0000009372 0.59315 32.2476
247 5UR1 YY9 0.0000003335 0.60857 32.4759
248 2OFV 242 0.0000008559 0.58058 32.491
249 5DEY 59T 0.0000001701 0.43084 32.6599
250 3SXS PP2 0.0000001087 0.60802 32.8358
251 2HK5 1BM 0.00000004036 0.59438 32.963
252 2Z7R STU 0.000000004986 0.65686 33.0218
253 3MVH WFE 0.000000003473 0.67229 33.0409
254 4RFM 3P6 0.000001174 0.424 33.0827
255 4BHN BH9 0.00000004653 0.62379 33.2335
256 5TO8 7FM 0.00000007284 0.63253 33.3333
257 4XV1 904 0.0000001332 0.61158 33.5616
258 4CLI 5P8 0.00000000293 0.70127 33.6391
259 4X7Q 3YR 0.000000001419 0.70771 33.6538
260 3BZ3 YAM 0.000001153 0.40681 33.6957
261 4NW6 2NS 0.00000005152 0.53114 33.7461
262 5TA6 79D 0.00000007879 0.55982 33.7989
263 3G5D 1N1 0.0000000108 0.69187 33.9161
264 5U6C 7YS 0.000000008016 0.64821 33.9683
265 4A4X JUP 0.00000001481 0.63793 34.0502
266 2RIO ADP 0.000000004338 0.60358 34.1207
267 5UIU 8CG 0.000000004691 0.66676 34.3653
268 4QMN DB8 0.000000003585 0.54629 34.5161
269 5UOX 8GY 0.00000005775 0.61226 34.6863
270 4I6H 1C8 0.0000006079 0.59026 34.7403
271 3SRV S19 0.0000000003137 0.64583 35.0181
272 4IX4 ADP 0.000003038 0.5239 35.4286
273 4L3L 5FI 0.00000003902 0.62776 35.5263
274 4F4P 0SB 0.00000006669 0.65973 35.5311
275 4CQE CQE 0.000001142 0.54454 35.6115
276 5FBN 5WF 0.0000003005 0.59836 35.7934
277 4CRL C1I 0.0000001186 0.51425 36.2205
278 3HZT J60 0.0000001926 0.51751 36.4829
279 4NFN 2KC 0.00001297 0.53728 36.5696
280 4WNP 3RJ 0.0000000002581 0.7756 36.5854
281 5IH9 6BF 0.0000002172 0.60635 36.7164
282 4TWP AXI 0.0000001317 0.4519 36.9004
283 5LVP ATP 0.0000000259 0.55688 36.9775
284 4EUU BX7 0.0000002744 0.58496 36.9906
285 3TTI KBI 0.00000002408 0.57796 37.0079
286 4WHZ 3NL 0.0000001565 0.44299 37.0079
287 4BFM ANP 0.000000005265 0.63107 37.4251
288 4BTK DTQ 0.000002868 0.51293 37.5328
289 4XLI 1N1 0.0000001908 0.62087 37.6866
290 3GQI ACP 0.00000003736 0.58165 38.0368
291 2JLD AG1 0.000000004264 0.56168 38.0577
292 3C0G 3AM 0.0000000215 0.68385 38.1766
293 3SXF BK5 0.0000003544 0.59527 38.3202
294 4QTB 38Z 0.00000000007591 0.73975 38.4211
295 2WEL K88 0.00000008675 0.49601 38.5321
296 3ZRM ZRM 0.00000001088 0.60058 38.5445
297 3GC8 B45 0.0000004052 0.57679 38.6486
298 4NM5 ADP 0.00000002626 0.61913 38.7268
299 3AQV TAK 0.0001391 0.44682 38.7681
300 3PTG 932 0.0000004001 0.5063 38.843
301 3FHR P4O 0.000001044 0.57273 38.9881
302 4UX9 ANP 0.000000008456 0.65547 39.011
303 4LOO SB4 0.00001417 0.48328 39.0582
304 1OUK 084 0.0000001214 0.68105 39.071
305 5HX8 66P 0.00000001794 0.59254 39.0728
306 3IGO ANP 0.0000003244 0.58084 39.1076
307 4IZY 1J2 0.00000001982 0.63964 39.2954
308 4H3Q ANP 0.000000001595 0.66913 39.5028
309 1CM8 ANP 0.00000006758 0.56077 39.5095
310 3KN5 ANP 0.00000004756 0.54956 39.6923
311 3E8N ATP 0.00000000334 0.70055 39.8827
312 3E8N VRA 0.00000000334 0.49081 39.8827
313 4F9C 0SX 0.00000007756 0.56151 39.8892
314 5EKO N17 0.00005905 0.48137 39.8922
315 3E7O 35F 0.0000009891 0.48863 40
316 5H2U 1N1 0.00000008612 0.62814 40.0749
317 4C2V YJA 0.000001226 0.5643 40.3509
318 5DA3 58V 0.00000001541 0.70167 40.3774
319 5AWM ANP 0.000000008579 0.71412 40.4199
320 3M2W L8I 0.000000006256 0.57797 40.4682
321 4H3P ANP 0.0000000001175 0.67126 40.6077
322 5BVE 4VG 0.00000003733 0.6738 40.7202
323 2B9I ADP 0.000000003742 0.68892 41.0765
324 2B9J ADP 0.000000006821 0.68687 41.0765
325 2B9H ADP 0.000000002965 0.63156 41.0765
326 4C2W ANP 0.00000003307 0.54141 41.2186
327 5DH3 5BS 0.00000006619 0.61724 41.2698
328 4NST ADP 0.000000002043 0.62583 41.3105
329 2B9F ADP 0.000000007016 0.60842 41.3598
330 4KS7 X4Z 0.000000132 0.59032 41.4384
331 5BYZ 4WE 0.000001587 0.49162 41.6667
332 5EFQ ADP 0.0000000006964 0.64216 41.7867
333 2VN9 GVD 0.00000000169 0.56996 41.8605
334 5EYK 5U5 0.000000393 0.53598 42.029
335 3OFM 4B0 0.0000000026 0.58462 42.2857
336 3BU5 ATP 0.0000000006522 0.64448 42.4837
337 3EKK GS2 0.00000001862 0.5197 42.671
338 2J7T 274 0.000002725 0.5496 42.7152
339 2XK9 XK9 0.000000002992 0.68687 42.8571
340 1PHK ATP 0.0000000006944 0.6524 42.953
341 2V7O DRN 0.000000003425 0.56756 43.1548
342 4JR7 GNP 0.00000002091 0.58807 43.3155
343 2PVN P63 0.000000004916 0.59231 43.4659
344 2ZV2 609 0.000000009723 0.71146 44.2953
345 5JZJ AN2 0.000000002061 0.71058 44.4444
346 1Q8Y ADP 0.0000000007632 0.66258 44.504
347 1Q8Y ADE 0.00000001192 0.53876 44.504
348 5LXM ADP 0.00000001172 0.67615 45.2297
349 3GC0 AMP 0.0000005229 0.5149 45.2888
350 5A6N U7E 0.0000003863 0.55284 45.583
351 2YAK OSV 0.000000007813 0.65737 45.614
352 2VZ6 FEF 0.00000005601 0.66398 45.6869
353 5L8L ADP 0.00000003065 0.68706 45.9649
354 5G1X ADP 0.000000009249 0.68084 45.9649
355 4FG8 ATP 0.0000002049 0.57033 46.0317
356 5EW9 5VC 0.000001401 0.62929 46.8635
357 3PE2 E1B 0.00000003734 0.65556 47.4777
358 4IJP 1EH 0.0000000007343 0.6639 47.486
359 5HQ0 LZ9 0.0000000002825 0.71862 47.6821
360 3E5A VX6 0.000000275 0.55807 47.7612
361 2BPM 529 0.000000000448 0.50326 47.8964
362 5MY8 RXZ 0.00000000189 0.67234 48.0315
363 4CFU 2WC 0.0000000002257 0.76605 48.8449
364 4BCQ TJF 0.00000001664 0.5546 49.1694
365 4BCM T7Z 0.00000001486 0.52572 49.1694
366 4AU8 Z3R 0.0000002168 0.64548 49.3243
367 4BCN T9N 0.000000001334 0.74152 49.3333
368 3O0G 3O0 0.000000001076 0.62687 49.6575
369 1UNH IXM 0.00000000128 0.60024 49.6575
370 2XMY CDK 0.0000002376 0.64014 49.6644
371 5LMK 6ZK 0.000001859 0.50534 49.8316
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