Receptor
PDB id Resolution Class Description Source Keywords
2WCO 1.94 Å EC: 4.2.2.1 STRUCTURES OF THE STREPTOMYCES COELICOLOR A3(2) HYALURONAN LYASE IN COMPLEX WITH OLIGOSACCHARIDE SUBSTRATES AND AN I NHIBITOR STREPTOMYCES COELICOLOR A3(2) LYASE FAMILY 8 GLYCOSAMINOGLYCANS (GAGS) HYDROLYSIS
Ref.: CRYSTAL STRUCTURES OF A FAMILY 8 POLYSACCHARIDE LYASE REVEAL OPEN AND HIGHLY OCCLUDED SUBSTRATE-BINDING CLEFT CONFORMATIONS. PROTEINS V. 79 965 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FMT A:1767;
A:1768;
Invalid;
Invalid;
none;
none;
submit data
46.025 C H2 O2 C(=O)...
GOL A:1766;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
NAG GC4 B:1;
Valid;
none;
submit data n/a n/a n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WDA 2.3 Å EC: 4.2.2.1 THE X-RAY STRUCTURE OF THE STREPTOMYCES COELICOLOR A3 CHONDROITIN AC LYASE IN COMPLEX WITH CHONDROITIN SULPHATE STREPTOMYCES VIOLACEORUBER LYASE HYALURONATE LYASE CHONDROITIN LYASE FAMILY 8
Ref.: CRYSTAL STRUCTURES OF A FAMILY 8 POLYSACCHARIDE LYASE REVEAL OPEN AND HIGHLY OCCLUDED SUBSTRATE-BINDING CLEFT CONFORMATIONS. PROTEINS V. 79 965 2011
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2WDA - ASG GCD n/a n/a
2 2WCO - NAG GC4 n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2WDA - ASG GCD n/a n/a
2 2WCO - NAG GC4 n/a n/a
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2WDA - ASG GCD n/a n/a
2 2WCO - NAG GC4 n/a n/a
3 1RWH - ASG GCT ASG GAD n/a n/a
4 1RWF - ASG GCT ASG GAD n/a n/a
5 1RWC - NAG GAD n/a n/a
6 1RWG - ASG GCT ASG GAD n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: NAG GC4; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2WDA; Ligand: L42; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2wda.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
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