-->
Receptor
PDB id Resolution Class Description Source Keywords
2W5Z 2.2 Å EC: 2.1.1.43 TERNARY COMPLEX OF THE MIXED LINEAGE LEUKAEMIA (MLL1) SET DOMAIN WITH THE COFACTOR PRODUCT S-ADENOSYLHOMOCYSTEINE A ND HISTONE PEPTIDE. HOMO SAPIENS TRANSCRIPTION REGULATION CHROMOSOMAL REARRANGEMENT PROTEIN LYSINE METHYLTRANSFERASE PROTO-ONCOGENE PHOSPHOPROTEIN UBL CONJUGATION S-ADENOSYL-L-METHIONINE MIXED LINEAGE LEUKAEMIA POLYMORPHISM TRANSCRIPTION METAL-BINDING ZINC-FINGER DNA-BINDING BROMODOMAIN TRANSFERASE METHYLTRANSFERASE CHROMATIN REGULATOR ALTERNATIVE SPLICING HISTONE MODIFICATION MLL1 ZINC KMT2A NUCLEUS APOPTOSIS SET DOMAIN
Ref.: STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONAL FACTORS FOR MLL1 SET DOMAIN ACTIVITY AND RECOGNITION OF EPIGENETIC MARKS. MOL.CELL V. 33 181 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA ARG THR MLY GLN THR ALA ARG TYR C:2;
Valid;
none;
submit data
968.124 n/a O=C([...
GOL A:4972;
A:4973;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SAH A:4971;
Valid;
none;
submit data
384.411 C14 H20 N6 O5 S c1nc(...
ZN A:4970;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2W5Z 2.2 Å EC: 2.1.1.43 TERNARY COMPLEX OF THE MIXED LINEAGE LEUKAEMIA (MLL1) SET DOMAIN WITH THE COFACTOR PRODUCT S-ADENOSYLHOMOCYSTEINE A ND HISTONE PEPTIDE. HOMO SAPIENS TRANSCRIPTION REGULATION CHROMOSOMAL REARRANGEMENT PROTEIN LYSINE METHYLTRANSFERASE PROTO-ONCOGENE PHOSPHOPROTEIN UBL CONJUGATION S-ADENOSYL-L-METHIONINE MIXED LINEAGE LEUKAEMIA POLYMORPHISM TRANSCRIPTION METAL-BINDING ZINC-FINGER DNA-BINDING BROMODOMAIN TRANSFERASE METHYLTRANSFERASE CHROMATIN REGULATOR ALTERNATIVE SPLICING HISTONE MODIFICATION MLL1 ZINC KMT2A NUCLEUS APOPTOSIS SET DOMAIN
Ref.: STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONAL FACTORS FOR MLL1 SET DOMAIN ACTIVITY AND RECOGNITION OF EPIGENETIC MARKS. MOL.CELL V. 33 181 2009
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 39 families.
1 2W5Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 2W5Y - SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 28 families.
1 2W5Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 2W5Y - SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 22 families.
1 4Z4P - SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 2W5Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 2W5Y - SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA ARG THR MLY GLN THR ALA ARG TYR; Similar ligands found: 133
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA ARG THR MLY GLN THR ALA ARG TYR 1 1
2 ALA ARG THR MLY GLN 0.66055 0.893939
3 ALA ARG THR MLY GLN THR ALA ARG LYS TYR 0.646018 0.893939
4 ALA ARG THR MLY GLN THR ALA 0.646018 0.893939
5 ALA ARG THR M3L GLN THR ALA ARG 0.623932 0.882353
6 ALA ARG THR MLY GLN THR ALA ARG LYS 0.612069 0.878788
7 ALA ARG THR M3L GLN THR ALA ALA LYS ALA 0.579365 0.882353
8 ALA THR ALA ALA ALA THR GLU ALA TYR 0.565217 0.681818
9 LEU GLU LYS ALA ARG GLY SER THR TYR 0.5625 0.867647
10 ALA THR VAL ARG THR TYR SER CYS 0.559055 0.808824
11 ALA ARG THR GLU LEU TYR ARG SER LEU 0.556391 0.865672
12 ALA ARG THR MLY GLN THR ALA ARG MLY SER 0.555556 0.878788
13 ALA ARG THR LYS GLN THR ALA ARG LYS 0.552846 0.757576
14 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.551724 0.876712
15 ACE ALA ARG THR GLU VAL TYR NH2 0.551181 0.833333
16 ALA 2MR THR MLY GLN THR ALA ALA 0.550847 0.893939
17 GLU ALA GLN THR ARG LEU 0.544715 0.757576
18 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.535433 0.835821
19 ALA ARG THR MLZ GLN THR ALA ARG LYS 0.535433 0.833333
20 ARG ARG ARG GLU THR GLN VAL 0.534483 0.772727
21 ACE GLU ALA GLN THR ARG LEU 0.524194 0.772727
22 ALA ARG THR M3L GLN THR ALA 2MR LYS 0.520661 0.867647
23 ALA ARG THR M3L GLN THR ALA 0.520661 0.867647
24 ALA ARG THR ALY GLN THR ALA 0.520661 0.787879
25 GLU LEU LYS TPO GLU ARG TYR 0.51773 0.819444
26 SER SER ARG LYS GLU TYR TYR ALA 0.515873 0.779412
27 SER GLU LEU GLU ILE LYS ARG TYR 0.514493 0.852941
28 ALA GLN ASP ILE TYR ARG ALA SER TYR 0.510345 0.8
29 SER ASP TYR GLN ARG LEU 0.507937 0.818182
30 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.503546 0.791045
31 THR ARG ARG GLU THR GLN LEU 0.5 0.787879
32 SER ARG TYR TRP ALA ILE ARG THR ARG 0.496732 0.736842
33 ALA DA2 THR M3L GLN THR ALA ARG ALA 0.49635 0.867647
34 PHE ALA GLY LEU ARG GLN ALA VAL THR GLN 0.496124 0.746269
35 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.496063 0.787879
36 ALA ARG THR M3L GLN THR ALA ARG LYS SER 0.491935 0.867647
37 ALA ARG THR M3L GLN THR ALA ARG LYS 0.491935 0.867647
38 ACE GLN THR ALA ARG PRK SER THR 0.48855 0.724638
39 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.485714 0.691176
40 ALA ARG THR MLZ GLN THR ALA ARG LYS TYR 0.484127 0.818182
41 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.483221 0.77027
42 ALA ARG THR M3L GLN THR ALA DA2 LYS 0.482993 0.867647
43 ALA GLN PHE SER ALA SER ALA SER ARG 0.48062 0.761194
44 ALA ARG THR ALA ALA THR ALA ARG LYS SER 0.478632 0.712121
45 ARG TYR GLY PHE VAL ALA ASN PHE 0.475524 0.771429
46 ALA GLN THR ALA ARG ALY SER THR 0.473684 0.776119
47 ALA ALA LEU THR ARG ALA 0.471074 0.727273
48 GLN THR ALA ARG M3L SER 0.469697 0.855072
49 ASN ALA LEU LEU ARG TYR LEU LEU ASP 0.466667 0.835821
50 ACE GLN THR ALA ARG KCR SER THR 0.463235 0.735294
51 PHQ GLN THR ALA ARG LYS NH2 FOA 0.463087 0.72
52 PHE LEU ARG GLY ARG ALA TYR GLY LEU 0.457746 0.782609
53 GLN THR ALA ARG M3L SER THR GLY 0.456522 0.855072
54 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.456376 0.782609
55 ALA ARG THR LYS GLN THR ALA ARG 0.455285 0.742424
56 LYS LYS ALA THR GLN ALA SEP GLN GLU TYR 0.455285 0.643836
57 PHE TYR ARG ALA LEU MET 0.453901 0.797101
58 ACE GLN THR ALA ARG BTK SER THR 0.451128 0.75
59 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.450704 0.764706
60 THR LYS ASN TYR LYS GLN THR SER VAL 0.446809 0.764706
61 ALA ARG MLY SER THR GLY GLY ALY 0.446809 0.882353
62 ARG GLY TYR LEU TYR GLN GLY LEU 0.446043 0.768116
63 ALA ARG THR 4WQ GLN THR ALA ARG LYS SER 0.442623 0.764706
64 VAL PRO LEU ARG PRO MET THR TYR 0.442308 0.853333
65 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.442177 0.835821
66 GLU THR VAL ARG PHE GLN SER ASP 0.441379 0.776119
67 ARG GLY TYR VAL TYR GLN GLY LEU 0.440559 0.768116
68 ALA LEU TYR ASN THR ALA ALA ALA LEU 0.438462 0.671642
69 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.438272 0.824324
70 SER GLU ILE GLU PHE ALA ARG LEU 0.4375 0.764706
71 GLY ALA ALA ARG ALA GLU VAL TYR LEU ARG 0.437086 0.848485
72 ASP GLU LEU GLU ILE LYS ALA TYR 0.43662 0.746269
73 SAC ARG GLY THR GLN THR GLU 0.43609 0.735294
74 ALA ARG THR MLY GLN THR ALA ARG LYS SER 0.434426 0.701493
75 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.434109 0.632353
76 GLY GLY LYS LYS ARG TYR LYS LEU 0.433824 0.820895
77 GLY GLY LYS LYS LYS TYR ARG LEU 0.433824 0.820895
78 GLY GLY ARG LYS LYS TYR LYS LEU 0.433824 0.820895
79 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.433735 0.779221
80 PRO ALA THR ILE MET MET GLN ARG GLY ASN 0.431818 0.753623
81 VAL ALA ARG SER 0.429825 0.671642
82 ASP ALA GLU PHE ARG HIS ASP 0.42963 0.712121
83 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.429448 0.849315
84 ARG PRO MET THR TYR LYS GLY ALA LEU 0.429412 0.866667
85 ALA ASN SER ARG TRP GLN THR SER ILE ILE 0.427673 0.710526
86 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.427673 0.746667
87 CYS THR GLU LEU LYS LEU SER ASP TYR 0.427586 0.764706
88 ALA THR ARG ASN PHE SER GLY 0.427536 0.73913
89 ALA GLU THR PHE 0.42735 0.621212
90 SER ARG ILE ARG ILE ARG GLY TYR VAL ARG 0.426573 0.84058
91 ARG HIS ARG MLY VAL LEU ARG ASP ASN 0.423841 0.833333
92 SER SER THR ARG GLY ILE SER GLN LEU TRP 0.423313 0.723684
93 ILE GLY PRO GLY ARG ALA PHE TYR THR ILE 0.422619 0.766234
94 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.421384 0.779221
95 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.420382 0.771429
96 TYR PRO LYS ARG ILE ALA 0.42 0.746667
97 SER SER ILE GLU PHE ALA ARG LEU 0.418919 0.779412
98 GLU LEU LYS ARG LYS MET ILE TYR MET 0.418301 0.852941
99 GLU ASN GLN LYS GLU TYR PHE PHE 0.41791 0.681159
100 ALA ARG 9AT 0.416667 0.69697
101 GLN ARG ALA THR LYS MET NH2 0.416058 0.791045
102 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.415663 0.782051
103 MET ABA LEU ARG MET THR ALA VAL MET 0.415493 0.779412
104 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.414966 0.7
105 GLU LEU ARG ARG LYS MET MET TYR MET 0.413793 0.880597
106 PHE ARG TYR LEU GLY 0.411765 0.768116
107 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.411429 0.769231
108 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.410596 0.838235
109 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.409938 0.814286
110 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.409357 0.782051
111 LEU TYR LEU VAL CYS GLY GLU ARG VAL 0.409091 0.794118
112 GLY ARG PHE GLN VAL THR 0.408759 0.731343
113 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.408451 0.710145
114 SER GLN ASN TYR 0.408333 0.661765
115 ALA THR ALY ALA ALA ARG ALY SER ALA PRO 0.408163 0.733333
116 ALA PHE ARG ILE PRO LEU THR ARG 0.407643 0.773333
117 LEU GLY GLY ALA LYS GLN ARG GLY ASP VAL 0.407407 0.701493
118 MET CYS LEU ARG MET THR ALA VAL MET 0.406897 0.80597
119 GLU LEU ARG SER ARG TYR TRP ALA ILE 0.406061 0.763158
120 ILE GLY PRO GLY ARG ALA PHE TYR THR 0.406061 0.74026
121 ACE ALA ARG THR LYS GLN 0.404762 0.727273
122 SER LEU ARG PHE LEU TYR GLU GLY 0.40411 0.8
123 GLU LEU ASN ARG LYS MET ILE TYR MET 0.403727 0.869565
124 THR ILE MET MET GLN ARG GLY 0.402985 0.768116
125 ILE GLN GLN SER ILE GLU ARG ILE 0.402985 0.720588
126 ALA VAL TYR ASN PHE ALA THR MET 0.402778 0.714286
127 ACE CSO ARG ALA THR LYS MET LEU 0.402778 0.780822
128 THR LYS ASN TYR LYS GLN PHE SER VAL 0.401408 0.728571
129 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.401316 0.753623
130 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.401198 0.702703
131 THR TYR LYS PHE PHE GLU GLN 0.4 0.720588
132 GLU ASN PRO THR TYR LYS PHE PHE GLU GLN 0.4 0.720588
133 ARG ARG ALA THR LYS MET NH2 0.4 0.791045
Ligand no: 2; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2W5Z; Ligand: SAH; Similar sites found with APoc: 33
This union binding pocket(no: 1) in the query (biounit: 2w5z.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 4NFE BEN None
2 3BFF FPM 1.04167
3 5WRI A3P 2.60417
4 2H21 SAM 3.125
5 4CM9 NAP 3.64583
6 4CLO NAP 3.64583
7 3JQ8 NAP 3.64583
8 3JQ9 NAP 3.64583
9 5UFN SAH 4.16667
10 3BIB PSF 4.31034
11 3QXY SAM 4.6875
12 2AE2 NAP 4.6875
13 2AE2 PTO 4.6875
14 5WHU SIA GAL 4.69799
15 3PDT ADP 5.09091
16 4L2I NAD 5.20833
17 4N65 AQN 5.72917
18 4N65 FMN 5.72917
19 2OWZ CIT 5.72917
20 5WRJ A3P 5.72917
21 5FFF 5XC 6.77083
22 4BMO FMN 7.56302
23 1MXH NAP 7.6087
24 1E8G FCR 7.8125
25 1E8G FAD 7.8125
26 6EOM ALA LYS 10.4167
27 3N71 SFG 16.6667
28 2BVE PH5 26.0504
29 5CZY SAM 29.6875
30 5JIY SAM 40.1042
31 5T0K SAM 40.1042
32 5WF7 A9G 40.625
33 3KMT SAH 45.3782
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