Receptor
PDB id Resolution Class Description Source Keywords
2W0Z 1.7 Å NON-ENZYME: SIGNAL_HORMONE GRB2 SH3C (3) HOMO SAPIENS SIGNALING PROTEIN POLYMORPHISM PHOSPHOPROTEIN GOLGI APPARATUS ALTERNATIVE SPLICING HOST-VIRUS INTERACTION SH3C GRB2 SIGNALING SH2 DOMAIN SH3 DOMAIN
Ref.: DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2. STRUCTURE V. 17 809 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA PRO PRO PRO ARG PRO PRO LYS PRO B:6;
Valid;
none;
submit data
943.185 n/a O=C(C...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2W0Z 1.7 Å NON-ENZYME: SIGNAL_HORMONE GRB2 SH3C (3) HOMO SAPIENS SIGNALING PROTEIN POLYMORPHISM PHOSPHOPROTEIN GOLGI APPARATUS ALTERNATIVE SPLICING HOST-VIRUS INTERACTION SH3C GRB2 SIGNALING SH2 DOMAIN SH3 DOMAIN
Ref.: DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2. STRUCTURE V. 17 809 2009
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 301 families.
1 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 221 families.
1 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
2 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
50% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 40 families.
1 6A9C - LYS VAL ALA PRO PRO ILE PRO HIS ARG n/a n/a
2 2J6O Kd ~ 100 uM LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL n/a n/a
3 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
4 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
5 1FYN - PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO n/a n/a
6 1ABO - ALA PRO THR MET PRO PRO PRO LEU PRO PRO n/a n/a
7 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
8 2D0N - PRO SER ILE ASP ARG SER THR LYS PRO n/a n/a
9 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
10 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
11 2SEM - ACE PRO PRO PRO VAL IPG PRO ARG ARG n/a n/a
12 3SEM - PRO PRO PRO VAL NMC PRO ARG ARG ARG n/a n/a
13 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
14 4HXJ Kd = 74.3 uM ARG GLY THR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA PRO PRO PRO ARG PRO PRO LYS PRO; Similar ligands found: 58
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA PRO PRO PRO ARG PRO PRO LYS PRO 1 1
2 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.688679 0.948276
3 GLY PRO ARG PRO 0.622449 0.946429
4 ALA PRO ASP THR ARG PRO 0.564103 0.846154
5 ARG PRO LYS PRO LEU VAL ASP PRO 0.533898 0.915254
6 ALA PRO ASP THR ARG PRO ALA PRO 0.532787 0.846154
7 THR LYS PRO ARG 0.518868 0.894737
8 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.495652 0.948276
9 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.479675 0.931035
10 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 0.474453 0.818182
11 SER PRO LYS ARG ILE ALA 0.467742 0.8125
12 TYR PRO SER LYS PRO ASP ASN PRO GLY GLU 0.467213 0.701493
13 ALA PRO ASP SER ARG PRO A2G 0.465278 0.753425
14 ALA PRO ASP CYS ARG PRO A2G 0.462069 0.733333
15 PRO PRO PRO PRO PRO PRO LEU PRO PRO 0.46087 0.827586
16 ASP LEU THR ARG PRO 0.459016 0.776119
17 ARG PRO LYS ARG ILE ALA 0.457364 0.868852
18 5JP PRO LYS ARG ILE ALA 0.453782 0.828125
19 ALA PRO ASP THR ARG PRO A2G 0.452703 0.753425
20 ARG PRO PRO GLY PHE SER PRO PHE ARG 0.442308 0.963636
21 ARG PRO PRO GLY PHE THR PRO PHE ARG 0.442308 0.963636
22 ARG GLU ARG SER PRO THR ARG 0.440678 0.825397
23 3BY PRO LYS ARG ILE ALA 0.440298 0.859375
24 ARG ARG ALA SEP ALA PRO LEU PRO 0.438849 0.797101
25 LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL 0.436508 0.915254
26 ALA PRO PRO ALA 0.43617 0.8
27 PRO PRO LYS ARG ILE ALA 0.42963 0.868852
28 ACE PRO PRO PRO VAL IPG PRO ARG ARG 0.428571 0.932203
29 ALA PRO THR MET PRO PRO PRO LEU PRO PRO 0.428571 0.685714
30 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.425532 0.887097
31 GLY HIS ARG PRO NH2 0.422764 0.866667
32 TYR PRO LYS ARG ILE ALA 0.41844 0.791045
33 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.417808 0.859375
34 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.417722 0.797101
35 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.416667 0.868852
36 DPN PRO ARG 0.415254 0.847458
37 LEU ASP PRO ARG 0.414634 0.809524
38 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.413793 0.824561
39 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.413333 0.80597
40 LYS PRO VAL LEU ARG THR ALA 0.413043 0.787879
41 PRO GLN ILE ILE ASN ARG PRO GLN ASN 0.411765 0.84127
42 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.411348 0.84375
43 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.410072 0.901639
44 DPN PRO DAR ILE NH2 0.409449 0.836066
45 PRO PRO ARG PRO ILE TYR ASN ARG ASN 0.409396 0.771429
46 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.408163 0.84375
47 ARG PRO PRO GLY PHE 0.407692 0.898305
48 PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG 0.407407 0.813559
49 SER ALA PRO ASP THR ARG PRO ALA 0.405797 0.833333
50 LYS PRO LYS 0.40566 0.789474
51 ASP GLN GLY ARG GLY ARG ARG ARG PRO 0.40458 0.866667
52 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.40411 0.80597
53 LYS THR PHE PRO PRO THR GLU PRO LYS 0.40411 0.716418
54 VAL MET LEU PRO GLY ARG GLY VAL PRO 0.402685 0.84375
55 GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS 0.401163 0.785714
56 PRO ALA ILE ILE ASN ARG PRO GLN ASN 0.4 0.84127
57 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.4 0.818182
58 PRO SER ILE ASP ARG SER THR LYS PRO 0.4 0.794118
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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