Receptor
PDB id Resolution Class Description Source Keywords
2VPE 1.7 Å NON-ENZYME: OTHER DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-BCL9 WNT COMPLEX HOMO SAPIENS GENE REGULATION WNT SIGNALING PATHWAY WNT SIGNALING COMPLECHROMOSOMAL REARRANGEMENT SIGNALING PROTEIN BCL9 HD1 DOMAHPYGO1 PHD DOMAIN PROTO-ONCOGENE PHOSPHOPROTEIN HISTONE ZINC NUCLEUS ZINC-FINGER METAL-BINDING
Ref.: DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-SIGNALING COMPLEX. MOL.CELL V. 30 507 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA ARG THR MLY GLN THR ALA P:1;
R:1;
Valid;
Valid;
none;
none;
Kd = 11.4 uM
n/a n/a
GOL A:1399;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
ZN A:1400;
A:1401;
C:1398;
C:1399;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2VPE 1.7 Å NON-ENZYME: OTHER DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-BCL9 WNT COMPLEX HOMO SAPIENS GENE REGULATION WNT SIGNALING PATHWAY WNT SIGNALING COMPLECHROMOSOMAL REARRANGEMENT SIGNALING PROTEIN BCL9 HD1 DOMAHPYGO1 PHD DOMAIN PROTO-ONCOGENE PHOSPHOPROTEIN HISTONE ZINC NUCLEUS ZINC-FINGER METAL-BINDING
Ref.: DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-SIGNALING COMPLEX. MOL.CELL V. 30 507 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 2VPE Kd = 11.4 uM ALA ARG THR MLY GLN THR ALA n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 2VPE Kd = 11.4 uM ALA ARG THR MLY GLN THR ALA n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 2VPE Kd = 11.4 uM ALA ARG THR MLY GLN THR ALA n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ALA ARG THR MLY GLN THR ALA; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Ligands (3D)
Ligand no: 1; Ligand: ALA ARG THR MLY GLN THR ALA; Similar ligands found: 1
No: Ligand Similarity coefficient
1 ALA ARG THR MLY GLN THR ALA 1.0000
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2VPE; Ligand: ALA ARG THR MLY GLN THR ALA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2vpe.bio2) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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