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Receptor
PDB id Resolution Class Description Source Keywords
2VO7 1.98 Å EC: 2.7.11.11 STRUCTURE OF PKA COMPLEXED WITH 4-(4-CHLOROBENZYL)-1-(7H- PYRROLO(2,3-D)PYRIMIDIN-4-YL)PIPERIDIN-4-YLAMINE BOS TAURUS TRANSFERASE LIPOPROTEIN ATP-BINDING PHOSPHOPROTEIN SERINE/THREONINE-PROTEIN KINASE NUCLEOTIDE-BINDING PROTEIN KINASE INHIBITOR CAMP KINASE NUCLEUS MYRISTATE CYTOPLASM
Ref.: IDENTIFICATION OF 4-(4-AMINOPIPERIDIN-1-YL)-7H-PYRROLO[2,3-D]PYRIMIDINES AS SELECTIVE INHIBITORS OF PROTEIN KINASE B THROUGH FRAGMENT ELABORATION. J.MED.CHEM. V. 51 2147 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
M05 A:1351;
A:1352;
Valid;
Valid;
none;
none;
ic50 = 15 nM
342.846 C18 H21 Cl N5 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2GU8 2.2 Å EC: 2.7.11.11 DISCOVERY OF 2-PYRIMIDYL-5-AMIDOTHIOPHENES AS NOVEL AND POTENT INHIBITORS FOR AKT: SYNTHESIS AND SAR STUDIES HOMO SAPIENS CAMP-DEPENDENT PROTEIN KINASE PKA AKT KINASE DRUG DESIGN TERNARY COMPLEX SIGNALING PROTEIN TRANSFERASE/INHIBITOR COMPLEX
Ref.: DISCOVERY OF 2-PYRIMIDYL-5-AMIDOTHIOPHENES AS POTENT INHIBITORS FOR AKT: SYNTHESIS AND SAR STUDIES BIOORG.MED.CHEM.LETT. V. 16 4163 2006
Members (120)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 4XW5 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
2 2UW5 ic50 = 34 nM GVN C17 H16 Cl N3 c1cc(ccc1c....
3 2JDV - L20 C24 H23 N5 O Cc1c2cc(cc....
4 2VNY - M02 C10 H14 N6 c1[nH]c2c(....
5 4IE9 - PZX C11 H11 N3 O2 Cc1cc(n[nH....
6 3FJQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
7 2VO6 - M05 C18 H21 Cl N5 c1cc(ccc1C....
8 4UJ9 - S3N C20 H16 F3 N3 O2 c1cc(ccc1C....
9 1YDR Ki = 3 uM IQP C14 H17 N3 O2 S C[C@H]1CNC....
10 2C1A ic50 = 0.17 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
11 4UJA - 4L7 C17 H14 Br N3 O2 S c1cc2c(cc1....
12 2UW0 - GVK C22 H20 Cl N5 c1cc(ccc1c....
13 4DFX - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
14 3L9L ic50 = 167 nM L9L C21 H19 F3 N4 O S c1cc(ccc1C....
15 3X2V - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
16 3MVJ ic50 = 3200 nM XFE C11 H15 N5 Cc1c[nH]c2....
17 4HPU - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
18 4C35 ic50 = 0.56 uM NU3 C14 H11 N3 O2 c1cc(c2c(c....
19 4C38 ic50 = 17.4 nM VUP C11 H12 N6 O CCn1c2cc(n....
20 3ZO4 ic50 = 149 nM QWI C20 H24 N6 c1ccc(cc1)....
21 2OJF ic50 = 15 nM 4PY C22 H20 N6 O c1c(cncc1O....
22 4XW4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
23 2GNF Ki = 6 uM Y27 C14 H21 N3 O C[C@H](C1C....
24 2JDS ic50 = 27 nM L20 C24 H23 N5 O Cc1c2cc(cc....
25 3E8E - G98 C24 H29 N7 O3 CCn1c2cc(n....
26 1SVG ic50 = 2 nM I04 C27 H27 F N4 O5 COc1ccc(c(....
27 2UW3 ic50 = 80 uM GVG C10 H10 N2 Cc1c(c[nH]....
28 3L9N - L9N C19 H20 N6 S Cc1ccc(cc1....
29 2UZW Kd = 5 nM SS4 C22 H21 Br N4 O Cc1c2cc(cc....
30 3X2W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
31 2GNJ Ki = 6 uM Y27 C14 H21 N3 O C[C@H](C1C....
32 2VO0 - M03 C18 H20 Cl N5 c1cc(ccc1C....
33 1L3R - AF3 Al F3 F[Al](F)F
34 4O21 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
35 6E99 ic50 = 1 uM J0G C23 H26 N4 O2 C[C@H](c1c....
36 1XH5 Kd = 3400 nM R68 C33 H38 F N5 O4 CC1(CCCN[C....
37 2JDT - I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
38 2ERZ Ki = 2.2 uM HFS C14 H17 N3 O3 S c1cc2c(ccn....
39 1Q8W Kd = 5.7 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
40 1STC Ki = 8 nM STU C28 H26 N4 O3 C[C@@]12[C....
41 5UZK Ki = 180 nM 504 C26 H29 N5 O2 S c1cc(cc(c1....
42 4IAZ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
43 2UVX - GVH C7 H6 N2 c1cc2cc[nH....
44 4YXR - 0RW C8 H8 N2 Cc1c2ccccc....
45 1RDQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
46 4YXS - EMU C12 H11 N5 c1ccc(cc1)....
47 1Q8T Kd = 17.5 uM Y27 C14 H21 N3 O C[C@H](C1C....
48 4IAI - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
49 2UW4 ic50 = 5.2 uM L15 C12 H15 N3 Cc1c(c[nH]....
50 2GNI Ki = 2280 nM M77 C14 H17 N3 O2 S c1cc2cnccc....
51 2UVY - GVI C13 H13 N5 CNCc1ccc(c....
52 1CDK - MYR C14 H28 O2 CCCCCCCCCC....
53 5VIB ic50 = 0.102 uM 9D1 C25 H26 N4 O S c1cc(cc(c1....
54 2C1B ic50 = 0.4 uM CQP C21 H22 Cl N3 O3 S c1cc2cnccc....
55 2UW8 ic50 = 77 uM GVQ C14 H14 Cl N c1ccc(cc1)....
56 3AMA Ki = 0.297 uM SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
57 2GNH Ki = 149 nM H52 C16 H21 N3 O2 S Cc1cncc2c1....
58 4IB0 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
59 1SVE ic50 = 5 nM I01 C27 H26 F N3 O6 COc1ccc(c(....
60 1XH4 Kd = 34 nM R69 C28 H31 N5 O4 CN(C)c1ccc....
61 2VO7 ic50 = 15 nM M05 C18 H21 Cl N5 c1cc(ccc1C....
62 2UZU ic50 = 0.16 nM L20 C24 H23 N5 O Cc1c2cc(cc....
63 4AXA - RKD C17 H17 Cl N3 O c1cc(ccc1c....
64 2F7E ic50 = 1.3 nM 2EA C25 H22 N4 O c1ccc2c(c1....
65 1XH8 ic50 = 1700 nM R55 C33 H39 N5 O4 CC1(CCN(CC....
66 3DNE - LL1 C12 H9 N3 c1ccc2c(c1....
67 4DG0 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
68 4C34 - STU C28 H26 N4 O3 C[C@@]12[C....
69 4IAC - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
70 2UZT ic50 = 14 nM SS3 C22 H22 N4 O Cc1c2cc(cc....
71 1JBP - OCT C8 H18 CCCCCCCC
72 1ATP Kd = 60 nM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
73 3OW3 ic50 = 742 nM SMY C22 H26 N6 O S C[C@H]1c2c....
74 4IB3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
75 3ZO3 - QNI C14 H20 N6 c1[nH]c2c(....
76 4C37 ic50 = 19.7 nM Z21 C10 H9 Br N6 O CCn1c2cc(n....
77 3E8C - G96 C24 H27 N7 O3 CCn1c2cc(n....
78 1Q8U Kd = 1.1 uM H52 C16 H21 N3 O2 S Cc1cncc2c1....
79 4Z83 - 4L7 C17 H14 Br N3 O2 S c1cc2c(cc1....
80 1YDT Ki = 48 nM IQB C20 H20 Br N3 O2 S c1cc2cnccc....
81 3L9M - L9M C20 H22 N6 S Cc1ccc(cc1....
82 3AMB Ki = 0.66 uM VX6 C23 H28 N8 O S Cc1cc([nH]....
83 3DND - LL2 C10 H10 N2 S c1ccc(cc1)....
84 4IAK - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
85 2UW6 ic50 = 0.28 uM GVO C17 H16 Cl N3 c1cc(ccc1c....
86 1XH7 Kd = 150 nM R96 C33 H39 N5 O4 CC1(CCCN(C....
87 3X2U - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
88 1XHA - R68 C33 H38 F N5 O4 CC1(CCCN[C....
89 4IAF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
90 4IAD - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3ZO1 ic50 = 1 uM SIJ C14 H20 N6 c1[nH]c2c(....
92 4HPT - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
93 4UJ1 - NVX C19 H16 Cl N3 O2 c1cc(cc(c1....
94 2OH0 ic50 = 18 nM 2PY C23 H21 N5 O c1cc2c(cc1....
95 4WB5 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
96 2F7X ic50 = 14 nM 4EA C23 H22 N4 O c1ccc2c(c1....
97 2UVZ - GVJ C18 H15 N5 c1ccc(cc1)....
98 3NX8 - IPH C6 H6 O c1ccc(cc1)....
99 2UW7 ic50 = 18 nM GVP C20 H20 Cl N3 c1cc(ccc1c....
100 4Z84 - NVX C19 H16 Cl N3 O2 c1cc(cc(c1....
101 1XH6 Kd = 48 nM R94 C31 H35 N5 O4 c1cc(ccc1C....
102 2VNW - M01 C11 H16 N6 c1[nH]c2c(....
103 1FMO Ki = 2.3 nM ADN C10 H13 N5 O4 c1nc(c2c(n....
104 2UZV ic50 > 3 uM SS5 C29 H34 N4 O2 Cc1c2cc(cc....
105 4UJ2 - NVV C19 H16 I N3 O2 c1cc(cc(c1....
106 4IB1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
107 2QUR - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
108 4XW6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
109 5VI9 - 9D4 C19 H14 F N3 S c1cc(cc(c1....
110 1XH9 Kd = 17 nM R69 C28 H31 N5 O4 CN(C)c1ccc....
111 2GU8 ic50 = 0.1 nM 796 C19 H19 Cl2 N5 O S CNc1nccc(n....
112 2VO3 - M04 C19 H22 Cl N5 c1cc(ccc1C....
113 4WB8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
114 3ZO2 ic50 = 80 nM 15I C14 H20 N6 c1[nH]c2c(....
115 1SVH ic50 = 360 nM I08 C28 H28 F N3 O4 COc1ccc(c(....
116 1YDS Ki = 1.2 uM IQS C12 H15 N3 O2 S CNCCNS(=O)....
117 4IAY - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
118 4C36 ic50 = 19.8 nM ZO9 C13 H13 N5 O c1ccc2c(c1....
119 4UJB - 8BQ C19 H16 F N3 O2 c1cc(cc(c1....
120 5VHB - 9CY C21 H20 N2 O2 c1ccc(cc1)....
70% Homology Family (121)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 4XW5 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
2 2UW5 ic50 = 34 nM GVN C17 H16 Cl N3 c1cc(ccc1c....
3 2JDV - L20 C24 H23 N5 O Cc1c2cc(cc....
4 2VNY - M02 C10 H14 N6 c1[nH]c2c(....
5 4IE9 - PZX C11 H11 N3 O2 Cc1cc(n[nH....
6 3FJQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
7 2VO6 - M05 C18 H21 Cl N5 c1cc(ccc1C....
8 4UJ9 - S3N C20 H16 F3 N3 O2 c1cc(ccc1C....
9 1YDR Ki = 3 uM IQP C14 H17 N3 O2 S C[C@H]1CNC....
10 2C1A ic50 = 0.17 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
11 4UJA - 4L7 C17 H14 Br N3 O2 S c1cc2c(cc1....
12 2UW0 - GVK C22 H20 Cl N5 c1cc(ccc1c....
13 4DFX - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
14 3L9L ic50 = 167 nM L9L C21 H19 F3 N4 O S c1cc(ccc1C....
15 3X2V - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
16 3MVJ ic50 = 3200 nM XFE C11 H15 N5 Cc1c[nH]c2....
17 4HPU - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
18 4C35 ic50 = 0.56 uM NU3 C14 H11 N3 O2 c1cc(c2c(c....
19 4C38 ic50 = 17.4 nM VUP C11 H12 N6 O CCn1c2cc(n....
20 3ZO4 ic50 = 149 nM QWI C20 H24 N6 c1ccc(cc1)....
21 2OJF ic50 = 15 nM 4PY C22 H20 N6 O c1c(cncc1O....
22 4XW4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
23 2GNF Ki = 6 uM Y27 C14 H21 N3 O C[C@H](C1C....
24 2JDS ic50 = 27 nM L20 C24 H23 N5 O Cc1c2cc(cc....
25 3E8E - G98 C24 H29 N7 O3 CCn1c2cc(n....
26 1SVG ic50 = 2 nM I04 C27 H27 F N4 O5 COc1ccc(c(....
27 2UW3 ic50 = 80 uM GVG C10 H10 N2 Cc1c(c[nH]....
28 3L9N - L9N C19 H20 N6 S Cc1ccc(cc1....
29 2UZW Kd = 5 nM SS4 C22 H21 Br N4 O Cc1c2cc(cc....
30 3X2W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
31 2GNJ Ki = 6 uM Y27 C14 H21 N3 O C[C@H](C1C....
32 2VO0 - M03 C18 H20 Cl N5 c1cc(ccc1C....
33 1L3R - AF3 Al F3 F[Al](F)F
34 4O21 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
35 6E99 ic50 = 1 uM J0G C23 H26 N4 O2 C[C@H](c1c....
36 1XH5 Kd = 3400 nM R68 C33 H38 F N5 O4 CC1(CCCN[C....
37 2JDT - I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
38 2ERZ Ki = 2.2 uM HFS C14 H17 N3 O3 S c1cc2c(ccn....
39 1Q8W Kd = 5.7 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
40 1STC Ki = 8 nM STU C28 H26 N4 O3 C[C@@]12[C....
41 5UZK Ki = 180 nM 504 C26 H29 N5 O2 S c1cc(cc(c1....
42 4IAZ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
43 2UVX - GVH C7 H6 N2 c1cc2cc[nH....
44 4YXR - 0RW C8 H8 N2 Cc1c2ccccc....
45 1RDQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
46 4YXS - EMU C12 H11 N5 c1ccc(cc1)....
47 1Q8T Kd = 17.5 uM Y27 C14 H21 N3 O C[C@H](C1C....
48 4IAI - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
49 2UW4 ic50 = 5.2 uM L15 C12 H15 N3 Cc1c(c[nH]....
50 2GNI Ki = 2280 nM M77 C14 H17 N3 O2 S c1cc2cnccc....
51 2UVY - GVI C13 H13 N5 CNCc1ccc(c....
52 1CDK - MYR C14 H28 O2 CCCCCCCCCC....
53 5VIB ic50 = 0.102 uM 9D1 C25 H26 N4 O S c1cc(cc(c1....
54 2C1B ic50 = 0.4 uM CQP C21 H22 Cl N3 O3 S c1cc2cnccc....
55 2UW8 ic50 = 77 uM GVQ C14 H14 Cl N c1ccc(cc1)....
56 3AMA Ki = 0.297 uM SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
57 2GNH Ki = 149 nM H52 C16 H21 N3 O2 S Cc1cncc2c1....
58 4IB0 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
59 1SVE ic50 = 5 nM I01 C27 H26 F N3 O6 COc1ccc(c(....
60 1XH4 Kd = 34 nM R69 C28 H31 N5 O4 CN(C)c1ccc....
61 2VO7 ic50 = 15 nM M05 C18 H21 Cl N5 c1cc(ccc1C....
62 2UZU ic50 = 0.16 nM L20 C24 H23 N5 O Cc1c2cc(cc....
63 4AXA - RKD C17 H17 Cl N3 O c1cc(ccc1c....
64 2F7E ic50 = 1.3 nM 2EA C25 H22 N4 O c1ccc2c(c1....
65 1XH8 ic50 = 1700 nM R55 C33 H39 N5 O4 CC1(CCN(CC....
66 3DNE - LL1 C12 H9 N3 c1ccc2c(c1....
67 4DG0 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
68 4C34 - STU C28 H26 N4 O3 C[C@@]12[C....
69 4IAC - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
70 2UZT ic50 = 14 nM SS3 C22 H22 N4 O Cc1c2cc(cc....
71 1JBP - OCT C8 H18 CCCCCCCC
72 1ATP Kd = 60 nM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
73 3OW3 ic50 = 742 nM SMY C22 H26 N6 O S C[C@H]1c2c....
74 4IB3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
75 3ZO3 - QNI C14 H20 N6 c1[nH]c2c(....
76 4C37 ic50 = 19.7 nM Z21 C10 H9 Br N6 O CCn1c2cc(n....
77 3E8C - G96 C24 H27 N7 O3 CCn1c2cc(n....
78 1Q8U Kd = 1.1 uM H52 C16 H21 N3 O2 S Cc1cncc2c1....
79 4Z83 - 4L7 C17 H14 Br N3 O2 S c1cc2c(cc1....
80 1YDT Ki = 48 nM IQB C20 H20 Br N3 O2 S c1cc2cnccc....
81 3L9M - L9M C20 H22 N6 S Cc1ccc(cc1....
82 3AMB Ki = 0.66 uM VX6 C23 H28 N8 O S Cc1cc([nH]....
83 3DND - LL2 C10 H10 N2 S c1ccc(cc1)....
84 4IAK - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
85 2UW6 ic50 = 0.28 uM GVO C17 H16 Cl N3 c1cc(ccc1c....
86 1XH7 Kd = 150 nM R96 C33 H39 N5 O4 CC1(CCCN(C....
87 3X2U - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
88 1XHA - R68 C33 H38 F N5 O4 CC1(CCCN[C....
89 4IAF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
90 4IAD - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3ZO1 ic50 = 1 uM SIJ C14 H20 N6 c1[nH]c2c(....
92 4HPT - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
93 4UJ1 - NVX C19 H16 Cl N3 O2 c1cc(cc(c1....
94 2OH0 ic50 = 18 nM 2PY C23 H21 N5 O c1cc2c(cc1....
95 4WB5 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
96 2F7X ic50 = 14 nM 4EA C23 H22 N4 O c1ccc2c(c1....
97 2UVZ - GVJ C18 H15 N5 c1ccc(cc1)....
98 3NX8 - IPH C6 H6 O c1ccc(cc1)....
99 2UW7 ic50 = 18 nM GVP C20 H20 Cl N3 c1cc(ccc1c....
100 4Z84 - NVX C19 H16 Cl N3 O2 c1cc(cc(c1....
101 1XH6 Kd = 48 nM R94 C31 H35 N5 O4 c1cc(ccc1C....
102 2VNW - M01 C11 H16 N6 c1[nH]c2c(....
103 1FMO Ki = 2.3 nM ADN C10 H13 N5 O4 c1nc(c2c(n....
104 2UZV ic50 > 3 uM SS5 C29 H34 N4 O2 Cc1c2cc(cc....
105 4UJ2 - NVV C19 H16 I N3 O2 c1cc(cc(c1....
106 4IB1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
107 2QUR - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
108 4XW6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
109 5VI9 - 9D4 C19 H14 F N3 S c1cc(cc(c1....
110 1XH9 Kd = 17 nM R69 C28 H31 N5 O4 CN(C)c1ccc....
111 2GU8 ic50 = 0.1 nM 796 C19 H19 Cl2 N5 O S CNc1nccc(n....
112 2VO3 - M04 C19 H22 Cl N5 c1cc(ccc1C....
113 4WB8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
114 3ZO2 ic50 = 80 nM 15I C14 H20 N6 c1[nH]c2c(....
115 1SVH ic50 = 360 nM I08 C28 H28 F N3 O4 COc1ccc(c(....
116 1YDS Ki = 1.2 uM IQS C12 H15 N3 O2 S CNCCNS(=O)....
117 4IAY - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
118 4C36 ic50 = 19.8 nM ZO9 C13 H13 N5 O c1ccc2c(c1....
119 4UJB - 8BQ C19 H16 F N3 O2 c1cc(cc(c1....
120 5VHB - 9CY C21 H20 N2 O2 c1ccc(cc1)....
121 4WB7 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
50% Homology Family (121)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 4XW5 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
2 2UW5 ic50 = 34 nM GVN C17 H16 Cl N3 c1cc(ccc1c....
3 2JDV - L20 C24 H23 N5 O Cc1c2cc(cc....
4 2VNY - M02 C10 H14 N6 c1[nH]c2c(....
5 4IE9 - PZX C11 H11 N3 O2 Cc1cc(n[nH....
6 3FJQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
7 2VO6 - M05 C18 H21 Cl N5 c1cc(ccc1C....
8 4UJ9 - S3N C20 H16 F3 N3 O2 c1cc(ccc1C....
9 1YDR Ki = 3 uM IQP C14 H17 N3 O2 S C[C@H]1CNC....
10 2C1A ic50 = 0.17 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
11 4UJA - 4L7 C17 H14 Br N3 O2 S c1cc2c(cc1....
12 2UW0 - GVK C22 H20 Cl N5 c1cc(ccc1c....
13 4DFX - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
14 3L9L ic50 = 167 nM L9L C21 H19 F3 N4 O S c1cc(ccc1C....
15 3X2V - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
16 3MVJ ic50 = 3200 nM XFE C11 H15 N5 Cc1c[nH]c2....
17 4HPU - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
18 4C35 ic50 = 0.56 uM NU3 C14 H11 N3 O2 c1cc(c2c(c....
19 4C38 ic50 = 17.4 nM VUP C11 H12 N6 O CCn1c2cc(n....
20 3ZO4 ic50 = 149 nM QWI C20 H24 N6 c1ccc(cc1)....
21 2OJF ic50 = 15 nM 4PY C22 H20 N6 O c1c(cncc1O....
22 4XW4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
23 2GNF Ki = 6 uM Y27 C14 H21 N3 O C[C@H](C1C....
24 2JDS ic50 = 27 nM L20 C24 H23 N5 O Cc1c2cc(cc....
25 3E8E - G98 C24 H29 N7 O3 CCn1c2cc(n....
26 1SVG ic50 = 2 nM I04 C27 H27 F N4 O5 COc1ccc(c(....
27 2UW3 ic50 = 80 uM GVG C10 H10 N2 Cc1c(c[nH]....
28 3L9N - L9N C19 H20 N6 S Cc1ccc(cc1....
29 2UZW Kd = 5 nM SS4 C22 H21 Br N4 O Cc1c2cc(cc....
30 3X2W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
31 2GNJ Ki = 6 uM Y27 C14 H21 N3 O C[C@H](C1C....
32 2VO0 - M03 C18 H20 Cl N5 c1cc(ccc1C....
33 1L3R - AF3 Al F3 F[Al](F)F
34 4O21 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
35 6E99 ic50 = 1 uM J0G C23 H26 N4 O2 C[C@H](c1c....
36 1XH5 Kd = 3400 nM R68 C33 H38 F N5 O4 CC1(CCCN[C....
37 2JDT - I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
38 2ERZ Ki = 2.2 uM HFS C14 H17 N3 O3 S c1cc2c(ccn....
39 1Q8W Kd = 5.7 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
40 1STC Ki = 8 nM STU C28 H26 N4 O3 C[C@@]12[C....
41 5UZK Ki = 180 nM 504 C26 H29 N5 O2 S c1cc(cc(c1....
42 4IAZ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
43 2UVX - GVH C7 H6 N2 c1cc2cc[nH....
44 4YXR - 0RW C8 H8 N2 Cc1c2ccccc....
45 1RDQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
46 4YXS - EMU C12 H11 N5 c1ccc(cc1)....
47 1Q8T Kd = 17.5 uM Y27 C14 H21 N3 O C[C@H](C1C....
48 4IAI - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
49 2UW4 ic50 = 5.2 uM L15 C12 H15 N3 Cc1c(c[nH]....
50 2GNI Ki = 2280 nM M77 C14 H17 N3 O2 S c1cc2cnccc....
51 2UVY - GVI C13 H13 N5 CNCc1ccc(c....
52 1CDK - MYR C14 H28 O2 CCCCCCCCCC....
53 5VIB ic50 = 0.102 uM 9D1 C25 H26 N4 O S c1cc(cc(c1....
54 2C1B ic50 = 0.4 uM CQP C21 H22 Cl N3 O3 S c1cc2cnccc....
55 2UW8 ic50 = 77 uM GVQ C14 H14 Cl N c1ccc(cc1)....
56 3AMA Ki = 0.297 uM SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
57 2GNH Ki = 149 nM H52 C16 H21 N3 O2 S Cc1cncc2c1....
58 4IB0 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
59 1SVE ic50 = 5 nM I01 C27 H26 F N3 O6 COc1ccc(c(....
60 1XH4 Kd = 34 nM R69 C28 H31 N5 O4 CN(C)c1ccc....
61 2VO7 ic50 = 15 nM M05 C18 H21 Cl N5 c1cc(ccc1C....
62 2UZU ic50 = 0.16 nM L20 C24 H23 N5 O Cc1c2cc(cc....
63 4AXA - RKD C17 H17 Cl N3 O c1cc(ccc1c....
64 2F7E ic50 = 1.3 nM 2EA C25 H22 N4 O c1ccc2c(c1....
65 1XH8 ic50 = 1700 nM R55 C33 H39 N5 O4 CC1(CCN(CC....
66 3DNE - LL1 C12 H9 N3 c1ccc2c(c1....
67 4DG0 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
68 4C34 - STU C28 H26 N4 O3 C[C@@]12[C....
69 4IAC - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
70 2UZT ic50 = 14 nM SS3 C22 H22 N4 O Cc1c2cc(cc....
71 1JBP - OCT C8 H18 CCCCCCCC
72 1ATP Kd = 60 nM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
73 3OW3 ic50 = 742 nM SMY C22 H26 N6 O S C[C@H]1c2c....
74 4IB3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
75 3ZO3 - QNI C14 H20 N6 c1[nH]c2c(....
76 4C37 ic50 = 19.7 nM Z21 C10 H9 Br N6 O CCn1c2cc(n....
77 3E8C - G96 C24 H27 N7 O3 CCn1c2cc(n....
78 1Q8U Kd = 1.1 uM H52 C16 H21 N3 O2 S Cc1cncc2c1....
79 4Z83 - 4L7 C17 H14 Br N3 O2 S c1cc2c(cc1....
80 1YDT Ki = 48 nM IQB C20 H20 Br N3 O2 S c1cc2cnccc....
81 3L9M - L9M C20 H22 N6 S Cc1ccc(cc1....
82 3AMB Ki = 0.66 uM VX6 C23 H28 N8 O S Cc1cc([nH]....
83 3DND - LL2 C10 H10 N2 S c1ccc(cc1)....
84 4IAK - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
85 2UW6 ic50 = 0.28 uM GVO C17 H16 Cl N3 c1cc(ccc1c....
86 1XH7 Kd = 150 nM R96 C33 H39 N5 O4 CC1(CCCN(C....
87 3X2U - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
88 1XHA - R68 C33 H38 F N5 O4 CC1(CCCN[C....
89 4IAF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
90 4IAD - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3ZO1 ic50 = 1 uM SIJ C14 H20 N6 c1[nH]c2c(....
92 4HPT - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
93 4UJ1 - NVX C19 H16 Cl N3 O2 c1cc(cc(c1....
94 2OH0 ic50 = 18 nM 2PY C23 H21 N5 O c1cc2c(cc1....
95 4WB5 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
96 2F7X ic50 = 14 nM 4EA C23 H22 N4 O c1ccc2c(c1....
97 2UVZ - GVJ C18 H15 N5 c1ccc(cc1)....
98 3NX8 - IPH C6 H6 O c1ccc(cc1)....
99 2UW7 ic50 = 18 nM GVP C20 H20 Cl N3 c1cc(ccc1c....
100 4Z84 - NVX C19 H16 Cl N3 O2 c1cc(cc(c1....
101 1XH6 Kd = 48 nM R94 C31 H35 N5 O4 c1cc(ccc1C....
102 2VNW - M01 C11 H16 N6 c1[nH]c2c(....
103 1FMO Ki = 2.3 nM ADN C10 H13 N5 O4 c1nc(c2c(n....
104 2UZV ic50 > 3 uM SS5 C29 H34 N4 O2 Cc1c2cc(cc....
105 4UJ2 - NVV C19 H16 I N3 O2 c1cc(cc(c1....
106 4IB1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
107 2QUR - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
108 4XW6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
109 5VI9 - 9D4 C19 H14 F N3 S c1cc(cc(c1....
110 1XH9 Kd = 17 nM R69 C28 H31 N5 O4 CN(C)c1ccc....
111 2GU8 ic50 = 0.1 nM 796 C19 H19 Cl2 N5 O S CNc1nccc(n....
112 2VO3 - M04 C19 H22 Cl N5 c1cc(ccc1C....
113 4WB8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
114 3ZO2 ic50 = 80 nM 15I C14 H20 N6 c1[nH]c2c(....
115 1SVH ic50 = 360 nM I08 C28 H28 F N3 O4 COc1ccc(c(....
116 1YDS Ki = 1.2 uM IQS C12 H15 N3 O2 S CNCCNS(=O)....
117 4IAY - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
118 4C36 ic50 = 19.8 nM ZO9 C13 H13 N5 O c1ccc2c(c1....
119 4UJB - 8BQ C19 H16 F N3 O2 c1cc(cc(c1....
120 5VHB - 9CY C21 H20 N2 O2 c1ccc(cc1)....
121 4WB7 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: M05; Similar ligands found: 7
No: Ligand ECFP6 Tc MDL keys Tc
1 M05 1 1
2 M04 0.702703 0.927273
3 X39 0.595238 0.825397
4 M03 0.589744 0.909091
5 0XZ 0.5 0.742857
6 6J9 0.492958 0.75
7 5JT 0.4125 0.8
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2GU8; Ligand: 796; Similar sites found with APoc: 721
This union binding pocket(no: 1) in the query (biounit: 2gu8.bio1) has 136 residues
No: Leader PDB Ligand Sequence Similarity
1 1RZX ACE VAL LYS GLU SER LEU VAL None
2 5KK4 44E None
3 5C2N NAG None
4 4CQK PIO None
5 4WG0 CHD None
6 5KHD C2E None
7 3PN1 IVH 0.943396
8 5EQY 5RA 1.18694
9 5EXK 5AD 1.20846
10 1ZB6 GST 1.30293
11 4U98 ACP 1.48368
12 3WXL ADP 1.48368
13 5DZ2 212 1.48368
14 3ICS ADP 1.48368
15 3ICT ADP 1.48368
16 5FPE 3TR 1.48368
17 4NS3 NAD 1.48368
18 1HFU NAG NDG 1.78042
19 5VLQ ANP 1.78042
20 5CAD PCA 1.78042
21 1UPF URF 1.78571
22 4C5N ACP 1.81159
23 1TZD ADP 1.81818
24 6AP6 TLF 1.85874
25 1W2D ADP 1.88679
26 1W2D 4IP 1.88679
27 3KCC CMP 1.92308
28 3SHR CMP 2.00669
29 4IRX INS 2.02703
30 3A2Y TS5 2.03046
31 4YVN EBS 2.07715
32 2YW2 ATP 2.07715
33 6C1S EFV 2.07715
34 3K5I ADP 2.07715
35 5H9Y BGC BGC BGC BGC BGC 2.07715
36 2ORO 228 2.07715
37 5Y72 DST 2.08955
38 1OMO NAD 2.17391
39 4CC6 L5Y 2.20126
40 1F7K UMP 2.20588
41 3I6B KDO 2.22222
42 1IOW ADP 2.28758
43 1IOW PHY 2.28758
44 3I0O ADP 2.37389
45 3UDZ ADP 2.37389
46 6FL8 ADP 2.37389
47 6FL8 TIY 2.37389
48 2Q8E OGA 2.37389
49 1MWH GTG 2.37389
50 2OS2 OGA 2.37389
51 2P5B OGA 2.37389
52 2YBP 2HG 2.37389
53 4K37 SAM 2.37389
54 4K38 SAM 2.37389
55 4AR8 IP8 GLY PRO ALA 2.37389
56 4WJT NAG 2.39521
57 6EKZ SNP 2.43902
58 2RHO GDP 2.46154
59 3BWR GAL NGA SIA GAL BGC 2.57353
60 3KYF 5GP 5GP 2.5974
61 4JNJ BTN 2.6087
62 3TM0 ANP 2.6616
63 3TM0 B31 2.6616
64 3ZS7 ATP 2.66667
65 5KJW 53C 2.67062
66 2Z3U CRR 2.67062
67 5L2R MLA 2.67062
68 1VRP ADP 2.67062
69 3ETH ATP 2.67062
70 3OPT AKG 2.67062
71 5FXD H7Y 2.67062
72 1Y42 TYR 2.67062
73 3JQ3 ADP 2.67062
74 4B0T ADP 2.67062
75 1U6R ADP 2.67062
76 2V58 LZJ 2.67062
77 3A5Y KAA 2.67062
78 5FLJ QUE 2.68817
79 3P8N L4T 2.68817
80 2VYN NAD 2.69461
81 5UC1 486 2.7027
82 1ZTH ADP 2.71318
83 1ZP9 ATP 2.71318
84 3RE4 TO1 2.71318
85 1T3D CYS 2.76817
86 1Q7E MET 2.80374
87 1OJZ NAD 2.83019
88 1XDN ATP 2.88809
89 5TVA COA 2.91667
90 5K2M ADP 2.9304
91 2CBZ ATP 2.95359
92 5U9J GER 2.95858
93 3TII ANP 2.96736
94 4RD0 GDP 2.96736
95 3HQP OXL 2.96736
96 5KWW 6YA 2.96736
97 3HQP ATP 2.96736
98 2IRY DGT 2.9703
99 1OIJ AKG 2.99003
100 5TH5 MET 3.04183
101 3I9U DTU 3.04183
102 3KYG 5GP 5GP 3.0837
103 2AQX ATP 3.11419
104 1GT4 UNA 3.14465
105 4D4U FUC GAL NAG 3.1746
106 5TZO 7V7 3.19149
107 4R78 AMP 3.23625
108 5MW8 ATP 3.2641
109 1PK8 ATP 3.2641
110 4UBS DIF 3.2641
111 1JG9 GLC 3.2641
112 1A99 PUT 3.2641
113 5T8U LPA 3.2641
114 1JQN DCO 3.2641
115 2CDC XYS 3.2641
116 3FXU TSU 3.27869
117 1ULE GLA GAL NAG 3.33333
118 4N9I PCG 3.33333
119 1Y3A GDP 3.34347
120 2GQR ADP 3.37553
121 1FQK ALF 3.38462
122 1JG3 ADN 3.40426
123 4ZFL 4NK 3.4188
124 1W8S FBP 3.42205
125 3MBI HSX 3.48432
126 5N5U 7N8 3.50318
127 1AUX AGS 3.53698
128 2ZSC BTN 3.5461
129 4XZ3 ACP 3.56083
130 4XYM A12 3.56083
131 1F9V ADP 3.56083
132 5KR7 6X9 3.56083
133 4PAB THG 3.56083
134 1CKN GTP 3.63636
135 1CKM GTP 3.63636
136 6HDT BTN 3.7594
137 1FS5 TLA 3.7594
138 2HKA C3S 3.84615
139 2QK4 ATP 3.85757
140 3WVR AMP 3.85757
141 2VL1 GLY GLY 3.85757
142 2CFM AMP 3.85757
143 4NOS ITU 3.85757
144 3R1Z ALA DGL 3.85757
145 5AYV NAP 3.8835
146 1NE6 SP1 3.88693
147 4RDL FUC GAL NDG FUC 3.8961
148 4AVB CMP 3.9039
149 4OUJ LBT 3.90879
150 3TDV GDP 3.92157
151 4KU7 PCG 3.92157
152 1KGI T4A 3.93701
153 5C5T AKG 3.94737
154 3OII SAH 3.95257
155 1Y52 BTN 3.96825
156 1QY1 PRZ 4.02299
157 1Y7P RIP 4.03587
158 3WUR O4B 4.09357
159 4QBK 3NZ 4.12371
160 3ZJX BOG 4.15225
161 4OUC 5ID 4.1543
162 4OCJ NDG 4.1543
163 3NKS ACJ 4.1543
164 6G34 5ID 4.1543
165 2Q7D ANP 4.1543
166 1ZGA HMK 4.1543
167 1ELI PYC 4.1543
168 4GCZ FMN 4.1543
169 1IXE COA 4.1543
170 5O3Q CMP 4.16667
171 4O9S 2RY 4.18605
172 4G9N NGA 4.1958
173 3A3B FMN 4.21053
174 3A3B RBF 4.21053
175 1L6O SER LEU LYS LEU MET THR THR VAL 4.21053
176 3NZ1 3NY 4.21456
177 4MOB ADP 4.21687
178 5OCG 9R5 4.2328
179 5C1P ADP 4.24837
180 5C1P DAL DAL 4.24837
181 4RHP PEF 4.25532
182 1IA9 ANP 4.28571
183 4DS0 A2G GAL NAG FUC 4.29448
184 4FE2 AIR 4.31373
185 4FE2 ADP 4.31373
186 1JGS SAL 4.34783
187 4GN8 ASO 4.34783
188 5ICK FEZ 4.36681
189 5SVV FMN 4.37956
190 2PYY GLU 4.38596
191 1GSA ADP 4.43038
192 4ZGP ADP 4.43686
193 2IF8 ADP 4.45104
194 5LXT ACP 4.45104
195 4WOE 3S5 4.45104
196 2OJW ADP 4.45104
197 5V7I 8Z1 4.45104
198 4WOE ADP 4.45104
199 1FWV SGA MAG FUC 4.47761
200 3GD8 GOL 4.4843
201 5F90 GLA GAL BGC 5VQ 4.48718
202 5F90 GLA GAL 4.48718
203 3K56 IS3 4.51128
204 5FUI APY 4.54545
205 4Y24 TD2 4.54545
206 6FA4 D1W 4.62428
207 4DFU QUE 4.65839
208 5C4L 4XR 4.6729
209 5C4L SIS 4.6729
210 3X01 AMP 4.74777
211 1VBH PEP 4.74777
212 4LIT AKG 4.74777
213 5OM2 DXT 4.74777
214 3T4L ZEA 4.81482
215 3SAO DBH 5
216 1UW1 ADP 5
217 5I35 ANP 5.04451
218 2PYW ADP 5.04451
219 3V4S ATP 5.04451
220 3E7S AT2 5.04451
221 1GPM AMP 5.04451
222 3RS8 ALA TRP LEU PHE GLU ALA 5.04451
223 1F52 ADP 5.04451
224 4S15 4D8 5.07812
225 2RDE C2E 5.17928
226 2XG5 EC2 5.20231
227 2XG5 EC5 5.20231
228 4PZ6 GMP 5.34125
229 5W75 SUC 5.34125
230 2XN2 GLA 5.34125
231 5OSW DIU 5.34125
232 1JXN MFU 5.3719
233 1SDW IYT 5.41401
234 2G30 ALA ALA PHE 5.42636
235 5O1I 9GH 5.47945
236 1ZEA DVA DPR GLY DSN DGN DHI DTY DAS DSN 5.55556
237 2IO8 ADP 5.63798
238 4UWH JXM 5.63798
239 5NM7 GLY 5.6391
240 3OF1 CMP 5.69106
241 5F6U 5VK 5.73248
242 4AZ3 S35 5.80645
243 4V03 ADP 5.83658
244 4USI ATP 5.84416
245 4NB5 2JT 5.84795
246 3BBD SAH 5.85366
247 3BP1 GUN 5.86207
248 1PVC ILE SER GLU VAL 5.88235
249 6FFK D7Z 5.88235
250 5M6N 7H9 5.9322
251 1C1X HFA 5.93472
252 3TY5 ATP 5.93472
253 2QPU QPU 5.93472
254 1NJJ GET 5.93472
255 2QPU QPS 5.93472
256 1BW9 NAD 5.93472
257 1BW9 PPY 5.93472
258 5Y0T TAT 5.93472
259 1QK3 5GP 6.00858
260 1X92 M7P 6.03015
261 2W5P CL8 6.04027
262 3VPD ANP 6.04982
263 5CIC 51R 6.12245
264 1H5R G1P 6.14334
265 3P7N FMN 6.20155
266 5XG5 A2G 6.2069
267 5HV7 RBL 6.23145
268 5YK1 ANP 6.23145
269 3ORQ ADP 6.23145
270 2FB3 MET 6.23145
271 2FB3 5AD 6.23145
272 2X3J ATP 6.23145
273 1RJW ETF 6.23145
274 4I9B NAD 6.23145
275 4RT1 C2E 6.25
276 3QH2 3NM 6.33484
277 3RGA LSB 6.36042
278 4IPH 1FJ 6.50407
279 5TVI MYR 6.52174
280 4O1P ANP 6.52819
281 2PUL ACP 6.52819
282 5OES ADP 6.52819
283 1LSH PLD 6.52819
284 3DNT ATP 6.52819
285 1EHI ADP 6.52819
286 5JJU AMP 6.52819
287 5J62 FMN 6.52819
288 4OCV ANP 6.59631
289 4X17 SIA SIA 6.61765
290 1W6U NAP 6.62252
291 1TQP ATP 6.73759
292 3AKK ADP 6.76923
293 2YRX AMP 6.82493
294 4OJ8 AKG 6.82493
295 3TTM PUT 6.82493
296 4PU5 ANP 6.84327
297 2D5X L35 6.84932
298 5ZCT ANP 6.86275
299 1VL1 CIT 6.89655
300 3P2H NOO 6.96517
301 3AHW 2AM 7.01754
302 1QKQ MAN 7.04225
303 2PTM CMP 7.07071
304 5L83 ASP TRP GLU ILE VAL 7.14286
305 2QHS OCA 7.173
306 1NU4 MLA 7.2165
307 1S68 AMP 7.22892
308 4K55 H6P 7.25806
309 6EAC ANP 7.4184
310 4LO2 GAL BGC 7.43243
311 3REU ATP 7.48299
312 5J75 6GQ 7.57576
313 4LRJ ANP 7.69231
314 4IX4 ADP 7.71513
315 3B2Q AES 7.71513
316 2ISJ FMN 7.82609
317 1OBD ATP 7.84314
318 4AVV CD 7.84314
319 2NZ5 226 8.01187
320 1W62 PYC 8.01187
321 2QHV OC9 8.09524
322 1UPR 4IP 8.13008
323 4M6T SAM 8.19672
324 5H6S HDH 8.30861
325 1GQG DCD 8.30861
326 3R9V DXC 8.39161
327 2BVE PH5 8.40336
328 5NFB 8VT 8.52273
329 1U29 I3P 8.52713
330 4JLS 3ZE 8.55263
331 5G0H E1Z 8.60534
332 4XMF HSM 8.69565
333 3QXV MTX 8.73016
334 3LF0 ATP 8.77193
335 2QX0 PH2 8.80503
336 6AC9 ANP 8.90208
337 5A4W QCT 8.96226
338 3EB9 FLC 9.02256
339 4Q9N 0WE 9.0604
340 4ZS4 ATP 9.12052
341 1UYY BGC BGC 9.16031
342 2ZL4 ALA ALA ALA ALA 9.18367
343 2Z6C FMN 9.30233
344 3F5A SIA GAL NAG 9.34959
345 2ET1 GLV 9.45274
346 3THR C2F 9.55631
347 5SYM 71Q 9.56522
348 1YXM ADE 9.57096
349 1S9D AFB 9.7561
350 4LO6 SIA GAL 9.79228
351 3CM2 X23 10
352 4R38 RBF 10
353 3CT5 NAG NAG NAG 10.0629
354 5TT6 ATP 10.089
355 3PDT ADP 10.1818
356 3IWD M2T 10.2941
357 3UW5 MAA CHG PRO 0DQ 10.3448
358 2ZL7 FUC GAL NGA 10.5085
359 5IKI A9H 10.6825
360 5E65 5N6 GAL 10.8434
361 1OFU GDP 10.9244
362 3TPV ADE 10.9792
363 3EFS ATP 11.1588
364 3EFS BTN 11.1588
365 6CED EYA 11.215
366 3VPC ADP 11.3475
367 3VPB ADP 11.3475
368 4WUJ FMN 11.5646
369 3HAV ATP 11.7057
370 2J9D ADP 11.7647
371 2GQS C2R 11.8143
372 2GQS ADP 11.8143
373 2BKK ADP 11.8343
374 3Q60 ATP 11.8694
375 5E62 Z3Q GAL 5N6 12.0805
376 2GC0 PAN 12.234
377 3WG3 A2G GAL NAG FUC 12.3596
378 5DKK FMN 12.4138
379 4O4F ATP 12.5
380 4O4F IHP 12.5
381 5B09 4MX 12.5
382 3VX3 ADP 12.5
383 3VOT ADP 12.7596
384 5YW5 ADE 12.8492
385 1QPR PPC 13.0282
386 3T2W BTN 13.1148
387 1F5F DHT 13.1707
388 5ZFJ 9BF 13.2159
389 5CKW ANP 13.3531
390 3KIH GDL 13.4021
391 5LX9 OLB 13.6808
392 5H9P TD2 13.9241
393 4OH4 ANP 14.4144
394 5DMZ ADP 14.5401
395 5LPZ ADP 14.759
396 2ZMF CMP 14.8148
397 5LWY OLB 14.9533
398 5OQW A4E 14.9606
399 5Y4R C2E 15
400 5XLY C2E 15
401 2VPQ ANP 15
402 2HGS ADP 15
403 6DW2 HD4 15
404 5COU ATP 15
405 1I1E DM2 15
406 4HWT 1B2 15
407 4J7H TLO 15
408 3IO3 ADP 15.1335
409 2QLU ADE 15.2866
410 5HWV MBN 15.3846
411 4IJP 1EH 16.0237
412 2RIO ADP 16.0237
413 2WUL GSH 16.1017
414 5EJL C2E 16.129
415 5LPB ADP 16.2162
416 4IEN GDP 16.5644
417 1BC5 ACE ASN TRP GLU THR PHE 16.7286
418 4YEE 4CQ 17.7778
419 4GYI ADP 18.1009
420 4WW7 AMP 18.3908
421 3SJK LYS PRO VAL LEU ARG THR ALA 18.4211
422 5N1X 8HH 18.6441
423 2CSN CKI 18.8552
424 1V3S ATP 18.9655
425 2XRH NIO 19
426 3H0L ADP 19.1489
427 4CYI ATP 19.8813
428 4DDY DN6 20
429 6FX2 FUC C4W NAG BMA MAN NAG GAL 20
430 1LDN FBP 20
431 3ACL 3F1 20
432 4DDS 0J7 20
433 1KJ8 ATP 20
434 3VHE 42Q 20.4748
435 4I94 ANP 21.3333
436 4YZC STU 21.365
437 5C03 AGS 21.365
438 4WOV 3SM 22.7129
439 4Y0X ADP 22.8487
440 5DZT AMP 22.8487
441 4Q5H ANP 23.6842
442 2PZI AXX 23.7389
443 2VQD AP2 25
444 5AE9 OKO 25
445 4YRI 4JH 25
446 2IVD ACJ 25
447 6EZ6 C5Z 25
448 2BIF BOG 25
449 1T36 ADP 25
450 5JM8 ATP 25
451 6BFN DL1 25.5193
452 3HMO STU 25.731
453 1CBK ROI 26.25
454 4CRL C1I 26.8473
455 5OMY 9YE 26.8542
456 4JR7 GNP 27.003
457 5GZ9 ANP 27.2131
458 5N87 N66 27.7955
459 1Q8Y ADE 27.8932
460 1Q8Y ADP 27.8932
461 4BTK DTQ 27.8932
462 3UIM ANP 27.9141
463 5KO1 6UY 27.9152
464 5UIU 8CG 28.1734
465 3VRY B43 28.1899
466 4IDT T28 28.1899
467 1U5R ATP 28.4866
468 5MY8 RXZ 28.7834
469 3C1X CKK 28.7834
470 4E93 GUI 28.7834
471 3PP0 03Q 28.7834
472 3LXN MI1 28.9308
473 3KMW ATP 29.1513
474 1VJY 460 29.3729
475 5BVE 4VG 29.3769
476 5T8O 76Z 29.3769
477 4H3P ANP 29.6736
478 4H3Q ANP 29.6736
479 4XH0 ADP 29.6736
480 3H9R TAK 29.697
481 4G17 0VN 29.697
482 6GWR FEW 29.8413
483 6GIN IR2 29.9003
484 6FYL 3NG 30
485 4AZW ATP 30
486 6CGD GNP 30
487 6CGD AKN 30
488 4RF7 ARG 30
489 5YJS SAL 30
490 6DZN AE3 30
491 5FI4 5XV 30
492 5IM3 DTP 30
493 5DJU FMN 30
494 5WS9 OXL 30
495 1SQL GUN 30
496 5OF1 SAL 30
497 5WS9 ATP 30
498 2YKL NLD 30
499 4XTR ADP 30
500 3KXC PLM 30
501 5HCY 60D 30.2115
502 4QTB 38Z 30.2671
503 5QIN J2V 30.3797
504 5EOB 5QQ 30.4075
505 4GJ3 0XP 30.4636
506 3E8N ATP 30.5638
507 3E8N VRA 30.5638
508 2PVN P63 30.6818
509 4NFN 2KC 30.7443
510 6F3G CJN 30.8475
511 4UX9 ANP 30.8605
512 3GNI ATP 30.8605
513 1Y57 MPZ 30.8605
514 2H8H H8H 30.8605
515 3ALN ANP 30.8869
516 6ES0 BW8 30.9148
517 4KBA 1QM 31.1178
518 5W4W 9WG 31.1178
519 5Y86 HRM 31.1573
520 2B9H ADP 31.1573
521 6GZD LCI 31.1573
522 3PE2 E1B 31.1573
523 2B9I ADP 31.1573
524 2B9J ADP 31.1573
525 4CLI 5P8 31.1927
526 4E1Z 0MX 31.2715
527 5JGA 6KC 31.4286
528 3LXK MI1 31.4985
529 5YF9 NIO 31.5634
530 3NW7 LGV 31.5961
531 5DBX ANP 31.7073
532 6FYV 3NG 31.7507
533 2WU6 DKI 31.7507
534 2B9F ADP 31.7507
535 5ZTN CUR 31.7507
536 4U44 3D9 31.9277
537 5X8I SQZ 32.0475
538 6G33 5ID 32.0475
539 5HVJ ANP 32.0635
540 5EH0 5NW 32.1705
541 3KRL KRL 32.2388
542 4P5Z Q7M 32.3442
543 1OPK P16 32.3442
544 2OO8 RAJ 32.4921
545 4NST ADP 32.6409
546 4NST AF3 32.6409
547 5WNL STU 32.6409
548 4F9C 0SX 32.6409
549 1CM8 ANP 32.6409
550 1K3A ACP 32.7759
551 3ORK AGS 32.7974
552 5OKT 9XK 32.8025
553 4Y85 499 32.8313
554 4IZY 1J2 32.9377
555 4Y8D 49J 32.9377
556 5TO8 7FM 32.9787
557 4AT3 LTI 33.1104
558 1OUK 084 33.2344
559 4LOO SB4 33.5312
560 4Y93 746 33.8279
561 5EFQ ADP 34.1246
562 3PLS ANP 34.2282
563 5AX9 4KT 34.4156
564 3PTG 932 34.4214
565 4FL3 ANP 34.4214
566 4WHZ 3NL 34.4214
567 3TTI KBI 34.4214
568 4QMN DB8 34.5161
569 4UXL 5P8 34.7826
570 4AU8 Z3R 34.7973
571 4AUA 4AU 34.8534
572 1I7L ATP 35
573 1E4E ADP 35
574 5TDF ADP 35
575 3W0O ADP 35
576 3W0O HY0 35
577 2Y69 CHD 35
578 5TVF PUT 35
579 5TVF CGQ 35
580 4OAV ACP 35
581 5YSZ CBI 35
582 4ASE AV9 35.1275
583 4M69 ANP 35.1438
584 2HK5 1BM 35.1852
585 4YZN 4K5 35.1916
586 4EWH T77 35.2727
587 5NKB 8ZT 35.2941
588 5AWM ANP 35.3116
589 5JFS 6K0 35.3896
590 2XVD AS6 35.4305
591 5Y80 IRE 35.4633
592 3DAK ANP 35.5172
593 4YMJ 4EJ 35.5263
594 2BPM 529 35.5987
595 1O9U ADZ 35.6083
596 3E7O 35F 35.6083
597 1UNH IXM 35.6164
598 4XV1 904 35.6164
599 3O0G 3O0 35.6164
600 5MJA 7O3 35.7377
601 5HES 032 35.8306
602 4NM5 ADP 35.905
603 2JLD AG1 35.905
604 5H2U 1N1 35.9551
605 6CQF F97 36.0269
606 3F7Z 34O 36.2018
607 3ZRM ZRM 36.2018
608 3GGF GVD 36.2126
609 4X7Q 3YR 36.2179
610 6CZ3 FLJ 36.3636
611 5WO4 B7V 36.4238
612 5M06 ADP 36.5942
613 2A19 ANP 36.6197
614 4CFU 2WC 36.6337
615 4G31 0WH 36.7893
616 1JPA ANP 36.859
617 4BCQ TJF 36.8771
618 4BCM T7Z 36.8771
619 2XMY CDK 36.9128
620 4EUU BX7 36.9906
621 4BCN T9N 37
622 4CQE CQE 37.0504
623 6GUE FB8 37.0861
624 3TKI S25 37.1517
625 2HY0 306 37.2671
626 4AG8 AXI 37.3418
627 5LMK 6ZK 37.3737
628 2F57 23D 37.3887
629 4ITH RCM 37.415
630 3SLS ANP 37.5
631 3SLS 77D 37.5
632 5U6C 7YS 38.0952
633 6C7Y ADP 38.1119
634 2Y6O 1N1 38.1443
635 4K33 ACP 38.1538
636 5UPK ANP 38.2789
637 2PVF ACP 38.3234
638 5CEO 50D 38.3333
639 4RFM 3P6 38.3459
640 5JKG 6LF 38.5852
641 4BHN BH9 38.6228
642 2OFV 242 38.6282
643 3DLS ADP 38.8724
644 1V0O INR 38.8889
645 5DH3 5BS 39.0476
646 5HQ0 LZ9 39.0728
647 6GU6 1QK 39.0728
648 3GQI ACP 39.2638
649 4FF8 14S 39.3189
650 1U59 STU 39.3728
651 3EKK GS2 39.4137
652 3IGO ANP 39.4659
653 5TA6 79D 39.4659
654 5VC5 96M 39.7924
655 3BU5 ATP 39.8693
656 6GQM F8H 39.939
657 3KN5 ANP 40
658 6A1G 9OL 40
659 6GNO XDI 40
660 5VZ0 ADP 40
661 5LUN OGA 40
662 2PX6 DH9 40
663 3FAL REA 40
664 4BFM ANP 40.1198
665 3CY2 MB9 40.1274
666 5USZ SKE 40.1384
667 3SXS PP2 40.2985
668 1IR3 ANP 40.5229
669 4N70 2HX 40.5488
670 3RI1 3RH 40.5751
671 2WQN ADP 40.6452
672 4CSV STI 40.7273
673 3G5D 1N1 40.9091
674 4U0I 0LI