Receptor
PDB id Resolution Class Description Source Keywords
2V88 2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF RAG2-PHD FINGER IN COMPLEX WITH H3R2ME2SK4ME2 PEPTIDE MUS MUSCULUS V(D)J RECOMBINATION COVALENT MODIFICATIONS RAG HISTONE NUCLEUS NUCLEASE HYDROLASE PHD FINGER DNA-BINDING RECOMBINASE ENDONUCLEASE DIMETHYL LYSINE DNA RECOMBINATION PROTEIN BINDING SYMMETRIC DIMETHYLATED ARGININE
Ref.: THE PLANT HOMEODOMAIN FINGER OF RAG2 RECOGNIZES HISTONE H3 METHYLATED AT BOTH LYSINE-4 AND ARGININE-2. PROC.NAT.ACAD.SCI.USA V. 104 18993 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA 2MR THR MLY GLN THR ALA ALA D:1;
F:1;
Valid;
Valid;
none;
none;
Kd = 82.1 uM
805.98 n/a O=C([...
ZN A:1488;
A:1489;
B:1488;
B:1489;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2V89 1.1 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF RAG2-PHD FINGER IN COMPLEX WITH H3K4ME3 PEPTIDE AT 1.1A RESOLUTION MUS MUSCULUS V(D)J RECOMBINATION COVALENT MODIFICATIONS RAG HISTONE NUCLEUS NUCLEASE HYDROLASE PHD FINGER DNA-BINDING RECOMBINASE ENDONUCLEASE TRIMETHYL LYSINE DNA RECOMBINATION PROTEIN BINDING
Ref.: RAG2 PHD FINGER COUPLES HISTONE H3 LYSINE 4 TRIMETH WITH V(D)J RECOMBINATION. NATURE V. 450 1106 2007
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 2V88 Kd = 82.1 uM ALA 2MR THR MLY GLN THR ALA ALA n/a n/a
2 2V86 Kd = 34.6 uM ALA DA2 THR M3L GLN THR ALA ARG ALA n/a n/a
3 2V83 Kd = 33.8 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
4 2V89 Kd = 4.15 uM ALA ARG THR M3L GLN THR ALA ALA LYS ALA n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 2V88 Kd = 82.1 uM ALA 2MR THR MLY GLN THR ALA ALA n/a n/a
2 2V86 Kd = 34.6 uM ALA DA2 THR M3L GLN THR ALA ARG ALA n/a n/a
3 2V83 Kd = 33.8 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
4 2V89 Kd = 4.15 uM ALA ARG THR M3L GLN THR ALA ALA LYS ALA n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 2V88 Kd = 82.1 uM ALA 2MR THR MLY GLN THR ALA ALA n/a n/a
2 2V86 Kd = 34.6 uM ALA DA2 THR M3L GLN THR ALA ARG ALA n/a n/a
3 2V83 Kd = 33.8 uM ALA ARG THR M3L GLN THR ALA ARG LYS n/a n/a
4 2V89 Kd = 4.15 uM ALA ARG THR M3L GLN THR ALA ALA LYS ALA n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA 2MR THR MLY GLN THR ALA ALA; Similar ligands found: 26
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA 2MR THR MLY GLN THR ALA ALA 1 1
2 ALA ARG THR MLY GLN THR ALA ARG LYS TYR 0.613861 1
3 ALA ARG THR MLY GLN THR ALA 0.613861 1
4 ALA ARG THR MLY GLN THR ALA ARG LYS 0.607843 0.983051
5 ALA ARG THR MLY GLN 0.59596 0.966667
6 ALA ARG THR MLY GLN THR ALA ARG TYR 0.550847 0.893939
7 ALA ARG THR MLY GLN THR ALA ARG MLY SER 0.543689 0.983051
8 ALA ARG THR M3L GLN THR ALA ARG 0.53211 0.951613
9 ALA ARG THR M3L GLN THR ALA 2MR LYS 0.490741 0.967213
10 ALA ARG THR M3L GLN THR ALA 0.490741 0.967213
11 ALA ARG THR LYS GLN THR ALA ARG LYS 0.486726 0.847458
12 ALA ARG THR M3L GLN THR ALA ARG LYS SER 0.486239 0.967213
13 ALA ARG THR M3L GLN THR ALA ARG LYS 0.486239 0.967213
14 ALA DA2 THR M3L GLN THR ALA ARG ALA 0.479675 0.967213
15 ALA ARG THR M3L GLN THR ALA ALA LYS ALA 0.478992 0.951613
16 ALA ARG THR ALY GLN THR ALA 0.477064 0.881356
17 ARG ARG ARG GLU THR GLN VAL 0.47619 0.833333
18 ALA ARG THR MLZ GLN THR ALA ARG LYS 0.470085 0.932203
19 ALA ARG THR MLZ GLN THR ALA ARG LYS TYR 0.464286 0.915254
20 LYS GLN THR SER VAL 0.4375 0.672131
21 ALA ARG THR LYS GLN THR ALA ARG 0.431193 0.830508
22 GLU ALA GLN THR ARG LEU 0.415254 0.816667
23 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.415254 0.85
24 ALA ARG THR M3L GLN THR ALA DA2 LYS 0.413043 0.967213
25 ALA ARG THR MLY GLN THR ALA ARG LYS SER 0.407407 0.783333
26 THR ARG ARG GLU THR GLN LEU 0.403509 0.85
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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