-->
Receptor
PDB id Resolution Class Description Source Keywords
2V5E 2.35 Å NON-ENZYME: SIGNAL_HORMONE THE STRUCTURE OF THE GDNF:CORECEPTOR COMPLEX: INSIGHTS INTO RET SIGNALLING AND HEPARIN BINDING. RATTUS NORVEGICUS RECEPTOR/GLYCOPROTEIN COMPLEX ALTERNATIVE SPLICING CELL MEMBRANE GROWTH FACTOR LIGAND-CORECEPTOR GPI-ANCHOR LIPOPROTEIN POLYMORPHISM GLYCOPROTEIN MEMBRANE RECEPTORSECRETED GFRALPHA1 CLEAVAGE ON PAIR OF BASIC RESIDUES
Ref.: THE STRUCTURE OF THE GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTS INTO RET SIGNALING AND HEPARIN BINDING. J.BIOL.CHEM. V. 283 35164 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:1351;
A:1352;
A:1353;
A:1354;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
NAG B:1135;
Invalid;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
SCR A:1350;
Valid;
none;
submit data
982.802 C12 H22 O35 S8 C([C@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2V5E 2.35 Å NON-ENZYME: SIGNAL_HORMONE THE STRUCTURE OF THE GDNF:CORECEPTOR COMPLEX: INSIGHTS INTO RET SIGNALLING AND HEPARIN BINDING. RATTUS NORVEGICUS RECEPTOR/GLYCOPROTEIN COMPLEX ALTERNATIVE SPLICING CELL MEMBRANE GROWTH FACTOR LIGAND-CORECEPTOR GPI-ANCHOR LIPOPROTEIN POLYMORPHISM GLYCOPROTEIN MEMBRANE RECEPTORSECRETED GFRALPHA1 CLEAVAGE ON PAIR OF BASIC RESIDUES
Ref.: THE STRUCTURE OF THE GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTS INTO RET SIGNALING AND HEPARIN BINDING. J.BIOL.CHEM. V. 283 35164 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 2V5E - SCR C12 H22 O35 S8 C([C@@H]1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 2V5E - SCR C12 H22 O35 S8 C([C@@H]1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 2V5E - SCR C12 H22 O35 S8 C([C@@H]1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SCR; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 SCR 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2V5E; Ligand: SCR; Similar sites found with APoc: 248
This union binding pocket(no: 1) in the query (biounit: 2v5e.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1UUY PPI None
2 5VWK PRO ALA TRP ASP GLU THR ASN LEU None
3 1WPV HIS None
4 3SE5 ANP None
5 3U5S FAD None
6 2QZT PLM None
7 5GUF CTP None
8 2II3 CAO None
9 3HX3 RET 1.5
10 4NTK ZSP 1.65289
11 5EKO N17 2
12 1FDQ HXA 2.29008
13 1VHT BA3 2.5
14 1WS1 BB2 2.9703
15 4RKK GLC GLC GLC GLC GLC GLC 2.9703
16 2A1L PCW 3
17 4EOX 0S5 3
18 1RQJ RIS 3
19 2F59 INI 3.18471
20 1OWB NAD 3.5
21 3SFI 3SF 3.5
22 4XRQ 1B0 3.5
23 5AAV GW5 3.5
24 5JF2 SF7 3.5
25 2ZKJ ADP 3.5
26 6B4H IHP 3.5
27 1UCD U5P 3.68421
28 4BPM GSH 3.93258
29 1PZO CBT 3.9604
30 2OBD 2OB 4
31 3HCN CHD 4
32 2OBD PCW 4
33 2EFX NFA 4
34 5KAU RHQ 4.5
35 1J78 VDY 4.5
36 5BQI 4UL 4.54545
37 5BQI GSH 4.54545
38 3KP6 SAL 4.63576
39 1T27 PCW 4.9505
40 1LQY BB2 4.9505
41 3R9C ECL 4.9505
42 5N9T 8QQ 4.9505
43 2JBZ COA 4.9505
44 5LPA 71R 5
45 5LPA ATP 5
46 4KBS PX2 5
47 3MBG FAD 5.03597
48 5ICE 2H4 5.5
49 5ICE SAH 5.5
50 3O55 FAD 5.6
51 1OQC FAD 5.6
52 5B4B LP5 5.94059
53 2OKL BB2 5.94059
54 4Q0P 0MK 5.94059
55 1S17 GNR 5.94059
56 6H8S FSZ 5.94059
57 5MU6 MYA 5.94059
58 5MU6 KFK 5.94059
59 5MTE BB2 5.94059
60 3ABA FLI 5.94059
61 4A38 BZS 5.94059
62 4WGF HX2 5.94059
63 3R1V AZB 5.94059
64 3GKJ HC3 5.94059
65 1IID NHM 6
66 2E3N 6CM 6
67 2EW5 Y12 6.07735
68 3ANP DCC 6.5
69 3ANP DAO 6.5
70 5BV6 35G 6.57895
71 1BII ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 6.72269
72 1HK8 DGT 6.93069
73 2BVN ENX 6.93069
74 1P1M MET 6.93069
75 4V3I ASP LEU THR ARG PRO 6.93069
76 5WX3 COA 6.93069
77 2GWH PCI 6.93069
78 1EE0 CAA 6.93069
79 5W0N 2KH 6.93069
80 6BJO DUY 6.93069
81 3VVY ET 6.93069
82 2FV5 541 6.93069
83 3AHQ FAD 6.93069
84 3RUG DB6 6.93069
85 5AHS SIN 6.93069
86 1NP7 FAD 6.93069
87 1TMX HGX 6.93069
88 1V7C HEY 7
89 4XCP PLM 7.05882
90 1G27 BB1 7.14286
91 2HJ3 FAD 7.2
92 5OCA 9QZ 7.5
93 4DQ2 BTX 7.5
94 2RH1 CLR 7.5
95 2EVL GAL SPH EIC 7.5
96 3FWN 6PG 7.5
97 6EVN PRO PRO GLY PRO ALA GLY PRO PRO GLY 7.84314
98 2AMV BIN 7.92079
99 6H21 UD1 7.92079
100 5AZC PGT 7.92079
101 3TGE TGE 7.92079
102 2BIF BOG 7.92079
103 4UWJ MYA 7.92079
104 4UWJ 7L5 7.92079
105 4PJT 2YQ 7.92079
106 5UC9 MYR 7.92079
107 3AB1 FAD 7.92079
108 4GU5 FAD 7.92079
109 3GFZ FMN 7.92079
110 1WPY BTN 8
111 3W54 RNB 8
112 4WO4 JLS 8
113 5WL1 CUY 8.08081
114 6BJ3 ILE PRO LEU THR GLU GLU ALA GLU LEU 8.08081
115 4JE7 BB2 8.12183
116 5XS3 VAL ARG SER ARG ARG CYS LEU ARG LEU 8.16327
117 5F1R 42O 8.5
118 4INW 1EY 8.57143
119 1BUC CAA 8.91089
120 3WYJ H78 8.91089
121 2BCG GER 8.91089
122 4KX8 L2O VAL VAL ASP 8.91089
123 6MPT C30 8.91089
124 3PVT 3HC 8.91089
125 6EQ8 BQZ 8.91089
126 2C78 PUL 8.91089
127 6EPY RAF 8.91089
128 3NB0 G6P 8.91089
129 4J7Q B7N 8.91089
130 6GAS FAD 8.91089
131 5V3Y 5V8 8.91089
132 3E7O 35F 9
133 3RMK BML 9
134 2VAT COA 9
135 2ALG HP6 9.78261
136 2ALG DAO 9.78261
137 4IEN GDP 9.81595
138 4DR9 BB2 9.90099
139 3KXC PLM 9.90099
140 1IYK MYA 9.90099
141 2YNE NHW 9.90099
142 2YNE YNE 9.90099
143 5DY5 5GR 9.90099
144 2YNC YNC 9.90099
145 5K7H IVC 9.90099
146 1B7H LYS NLE LYS 9.90099
147 2J4D FAD 9.90099
148 3U3U EAH 9.90099
149 3LZW FAD 9.90099
150 2ZCQ B65 10
151 5HW4 SAM 10
152 1BWO LPC 10
153 3WIS FMN 10.5
154 5OF9 ANP 10.8911
155 6B21 C9V 10.8911
156 4ZW3 4S9 10.8911
157 3CHT 4NB 10.8911
158 6GL8 F3Q 10.8911
159 1KJM ALA GLN PHE SER ALA SER ALA SER ARG 10.8911
160 2R7G PRO PRO THR LEU HIS GLU LEU TYR ASP LEU 11
161 1JR8 FAD 11.1111
162 3HDY FDA 11.5
163 3HDY GDU 11.5
164 1ESM COA 11.5
165 1MT1 AG2 11.5044
166 4B5P ACO 11.8812
167 4OMJ 2TX 11.8812
168 2VWA PTY 11.8812
169 2W90 6PG 11.8812
170 4XTR ATP 12.5
171 4XTR ADP 12.5
172 4XVU ATP 12.5
173 5F74 AMP 12.7551
174 6BR9 PGV 12.8713
175 5EEH P9P 12.8713
176 5W7D PX8 12.8713
177 3ET1 ET1 12.8713
178 6BR8 PGV 12.8713
179 2YOO K2B 12.8713
180 4RYV ZEA 12.8713
181 5V4R MGT 12.8713
182 4RHP PEF 12.8713
183 4MO2 FAD 12.8713
184 4U0S ADP 13
185 3RV5 DXC 13.4831
186 3Q8G PEE 13.8614
187 3T03 3T0 13.8614
188 3ET3 ET1 13.8614
189 5DH3 5BS 13.8614
190 4Z3X 4KX 13.8614
191 4Z3X MTE 13.8614
192 2Z7I 742 13.8614
193 2HFP NSI 13.8614
194 5EK3 5PK 13.8614
195 1QZR ANP 13.8614
196 4IBF 1D5 13.9535
197 4WAS NAP 14
198 4WAS COO 14
199 5Z84 TGL 14.1176
200 5Z84 PGV 14.1176
201 2DYR PGV 14.1176
202 5ZCO PGV 14.1176
203 2DYS PGV 14.1176
204 2DYS TGL 14.1176
205 2DYR TGL 14.1176
206 5ZCO TGL 14.1176
207 2DYS PSC 14.1176
208 6F68 4EU 14.5
209 6F68 GSH 14.5
210 4WZA ADP 14.8515
211 4WZA ACP 14.8515
212 3G5K BB2 14.8515
213 4CA5 3EF 14.8515
214 5AMC GLY NIY 14.8515
215 1DEK DGP 14.8515
216 4BXK 1IU 14.8515
217 5N69 2OW 15.8416
218 1K6M AGS 16.5
219 4YSX E23 16.6667
220 2IZ1 RES 16.8317
221 3TKI S25 17.8218
222 2PRG BRL 18.1818
223 6B2M COA 18.5
224 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 18.8119
225 2E2R 2OH 18.8119
226 2QQD AG2 18.8679
227 1B63 ANP 19.802
228 1M13 HYF 19.802
229 2XCG XCG 20.7921
230 5X4Q 7Z6 20.7921
231 4B1V ATP 21.5
232 4B1V LAB 21.5
233 3SJH LAR 21.5
234 5YEE LAB 21.5
235 4H03 LAR 21.5
236 4H03 ATP 21.5
237 2FXU ATP 21.5
238 4B1X LAB 21.5
239 5ZZA LAB 21.5
240 5ZZB LAB 21.5
241 4L1F COS 21.7822
242 1DKF BMS 22.7723
243 1Q1Y BB2 22.7723
244 1R6N 434 22.7723
245 5IKH 6BW 24.7525
246 4OGQ 7PH 33.6634
247 1OLM VTQ 35.6436
248 1UBY DMA 42.5743
Pocket No.: 2; Query (leader) PDB : 2V5E; Ligand: SCR; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2v5e.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback