Receptor
PDB id Resolution Class Description Source Keywords
2V5E 2.35 Å NON-ENZYME: SIGNAL_HORMONE THE STRUCTURE OF THE GDNF:CORECEPTOR COMPLEX: INSIGHTS INTO RET SIGNALLING AND HEPARIN BINDING. RATTUS NORVEGICUS RECEPTOR/GLYCOPROTEIN COMPLEX ALTERNATIVE SPLICING CELL MEMBRANE GROWTH FACTOR LIGAND-CORECEPTOR GPI-ANCHOR LIPOPROTEIN POLYMORPHISM GLYCOPROTEIN MEMBRANE RECEPTORSECRETED GFRALPHA1 CLEAVAGE ON PAIR OF BASIC RESIDUES
Ref.: THE STRUCTURE OF THE GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTS INTO RET SIGNALING AND HEPARIN BINDING. J.BIOL.CHEM. V. 283 35164 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:1351;
A:1352;
A:1353;
A:1354;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
NAG B:1135;
Invalid;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
SCR A:1350;
Valid;
none;
submit data
982.802 C12 H22 O35 S8 C([C@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2V5E 2.35 Å NON-ENZYME: SIGNAL_HORMONE THE STRUCTURE OF THE GDNF:CORECEPTOR COMPLEX: INSIGHTS INTO RET SIGNALLING AND HEPARIN BINDING. RATTUS NORVEGICUS RECEPTOR/GLYCOPROTEIN COMPLEX ALTERNATIVE SPLICING CELL MEMBRANE GROWTH FACTOR LIGAND-CORECEPTOR GPI-ANCHOR LIPOPROTEIN POLYMORPHISM GLYCOPROTEIN MEMBRANE RECEPTORSECRETED GFRALPHA1 CLEAVAGE ON PAIR OF BASIC RESIDUES
Ref.: THE STRUCTURE OF THE GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTS INTO RET SIGNALING AND HEPARIN BINDING. J.BIOL.CHEM. V. 283 35164 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 2V5E - SCR C12 H22 O35 S8 C([C@@H]1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 2V5E - SCR C12 H22 O35 S8 C([C@@H]1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 2V5E - SCR C12 H22 O35 S8 C([C@@H]1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SCR; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 SCR 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2V5E; Ligand: SCR; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2v5e.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2V5E; Ligand: SCR; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2v5e.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
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