Receptor
PDB id Resolution Class Description Source Keywords
2UZI 2 Å NON-ENZYME: IMMUNE CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV COMPLEX HOMO SAPIENS SIGNAL TRANSDUCTION IMMUNOGLOBULIN DOMAIN MEMBRANE ANTIBOONCOGENE PALMITATE INTRABODY DISEASE MUTATION NUCLEOTIDBINDING PROTO-ONCOGENE CANCER THERAPY GOLGI APPARATUS PRENYLATION METHYLATION LIPOPROTEIN GTP- BINDING SIGNALPROTEIN/IMMUNE SYSTEM SIGNALING PROTEIN-IMMUNE SYSTEM COMP
Ref.: TUMOUR PREVENTION BY A SINGLE ANTIBODY DOMAIN TARGE INTERACTION OF SIGNAL TRANSDUCTION PROTEINS WITH RA EMBO J. V. 26 3250 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GTP R:1167;
Valid;
none;
submit data
523.18 C10 H16 N5 O14 P3 c1nc2...
MG R:1168;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
ZN H:1115;
H:1116;
R:1169;
R:1170;
R:1171;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2UZI 2 Å NON-ENZYME: IMMUNE CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV COMPLEX HOMO SAPIENS SIGNAL TRANSDUCTION IMMUNOGLOBULIN DOMAIN MEMBRANE ANTIBOONCOGENE PALMITATE INTRABODY DISEASE MUTATION NUCLEOTIDBINDING PROTO-ONCOGENE CANCER THERAPY GOLGI APPARATUS PRENYLATION METHYLATION LIPOPROTEIN GTP- BINDING SIGNALPROTEIN/IMMUNE SYSTEM SIGNALING PROTEIN-IMMUNE SYSTEM COMP
Ref.: TUMOUR PREVENTION BY A SINGLE ANTIBODY DOMAIN TARGE INTERACTION OF SIGNAL TRANSDUCTION PROTEINS WITH RA EMBO J. V. 26 3250 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 208 families.
1 2UZI - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 62 families.
1 2UZI - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 42 families.
1 2UZI - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GTP; Similar ligands found: 156
No: Ligand ECFP6 Tc MDL keys Tc
1 GTP 1 1
2 GP3 0.921053 0.973684
3 GDP 0.909091 1
4 GSP 0.853659 0.948718
5 GNH 0.82716 0.986667
6 G1R 0.819277 0.986667
7 GAV 0.811765 0.961039
8 9GM 0.809524 0.973684
9 GNP 0.809524 0.973684
10 GCP 0.797619 0.973684
11 5GP 0.797468 0.986486
12 G 0.797468 0.986486
13 GMV 0.764706 0.973684
14 G2R 0.764045 0.961039
15 G5P 0.755319 0.973684
16 GTG 0.752688 0.936709
17 G2P 0.747126 0.961039
18 G3A 0.744681 0.973684
19 GDD 0.741935 0.961039
20 GDC 0.741935 0.961039
21 GKE 0.741935 0.961039
22 0O2 0.736264 0.986486
23 GP2 0.729412 0.961039
24 6CK 0.726316 0.936709
25 Y9Z 0.723404 0.902439
26 GPG 0.717391 0.961039
27 GFB 0.715789 0.961039
28 GDR 0.715789 0.961039
29 GPD 0.704082 0.925
30 GKD 0.693878 0.961039
31 JB2 0.693878 0.961039
32 GDX 0.686869 0.973684
33 ALF 5GP 0.685393 0.888889
34 GH3 0.681319 0.973333
35 YGP 0.677083 0.901235
36 G3D 0.67033 0.986486
37 GDP AF3 0.659574 0.888889
38 ALF GDP 0.659574 0.888889
39 GDP ALF 0.659574 0.888889
40 DGT 0.659341 0.923077
41 GMP 0.658228 0.88
42 G4P 0.655914 0.986486
43 JB3 0.653846 0.948718
44 NGD 0.647619 0.961039
45 CAG 0.642202 0.880952
46 2MD 0.62963 0.891566
47 MGP 0.619565 0.961039
48 U2G 0.616822 0.936709
49 6G0 0.612903 0.961039
50 MGD 0.612613 0.891566
51 TPG 0.608696 0.840909
52 CG2 0.605505 0.936709
53 GDP 7MG 0.601942 0.911392
54 FEG 0.601852 0.879518
55 G G 0.598039 0.948052
56 ZGP 0.59633 0.869048
57 PGD 0.591304 0.925
58 MD1 0.591304 0.891566
59 3GP 0.590909 0.946667
60 GPX 0.581633 0.946667
61 DGI 0.580645 0.923077
62 IDP 0.576087 0.972973
63 DBG 0.567797 0.948718
64 2GP 0.555556 0.96
65 FE9 0.555556 0.776596
66 G4M 0.547619 0.880952
67 BGO 0.544643 0.924051
68 GCP G 0.543689 0.921053
69 ATP 0.537634 0.92
70 HEJ 0.537634 0.92
71 G1G 0.533898 0.925
72 AQP 0.531915 0.92
73 5FA 0.531915 0.92
74 A G 0.525862 0.935065
75 G A A A 0.525862 0.923077
76 U A G G 0.521368 0.935065
77 HFD 0.520833 0.873418
78 R5I 0.520408 0.946667
79 R7I 0.520408 0.946667
80 01G 0.518868 0.902439
81 P2G 0.510638 0.883117
82 ITT 0.510638 0.868421
83 AKW 0.504348 0.890244
84 GGM 0.504274 0.901235
85 G1R G1R 0.504065 0.924051
86 DGP 0.5 0.910256
87 PGD O 0.5 0.850575
88 MGO 0.5 0.864198
89 DG 0.5 0.910256
90 P1G 0.5 0.871795
91 GTA 0.495495 0.936709
92 PRT 0.490741 0.959459
93 B4P 0.489362 0.894737
94 AP5 0.489362 0.894737
95 IMP 0.489362 0.959459
96 G U 0.487179 0.9
97 7DT 0.484536 0.906667
98 GPC 0.479339 0.879518
99 G C 0.478992 0.9
100 BA3 0.478723 0.894737
101 ADP 0.473684 0.92
102 G2Q 0.471698 0.961039
103 6YZ 0.470588 0.896104
104 G7M 0.46875 0.948052
105 C1Z 0.462963 0.986486
106 25L 0.458716 0.907895
107 A2D 0.457447 0.894737
108 RGT 0.45045 0.909091
109 AGS 0.45 0.873418
110 SAP 0.45 0.873418
111 SGP 0.44898 0.82716
112 A4P 0.445378 0.869048
113 G G G RPC 0.442623 0.875
114 ANP 0.441176 0.896104
115 ACQ 0.441176 0.896104
116 8GT 0.441176 0.875
117 APC G U 0.44 0.886076
118 AT4 0.438776 0.884615
119 G U34 0.438017 0.888889
120 6AD 0.436893 0.841463
121 G G G C 0.433071 0.9125
122 UP5 0.432203 0.873418
123 PCG 0.431373 0.933333
124 C2E 0.431373 0.921053
125 35G 0.431373 0.933333
126 A G C C 0.429688 0.911392
127 T99 0.427184 0.884615
128 5GP 5GP 0.427184 0.883117
129 TAT 0.427184 0.884615
130 AR6 0.425743 0.894737
131 APR 0.425743 0.894737
132 7DD 0.424242 0.906667
133 AN2 0.424242 0.907895
134 DG DG 0.423423 0.865854
135 AD9 0.421569 0.896104
136 M33 0.42 0.883117
137 7D4 0.42 0.835443
138 UCG 0.419847 0.911392
139 HDV 0.419048 0.825
140 H6Y 0.419048 0.946667
141 G C C C 0.416667 0.924051
142 ACP 0.415842 0.896104
143 T5A 0.414634 0.802326
144 A1R 0.412844 0.839506
145 ADQ 0.412844 0.871795
146 MGQ 0.412844 0.935897
147 A3R 0.412844 0.839506
148 MGT 0.411215 0.823529
149 A G U 0.410072 0.888889
150 93A 0.41 0.833333
151 A22 0.407407 0.907895
152 CA0 0.405941 0.896104
153 ATF 0.40566 0.884615
154 AGO 0.404762 0.888889
155 MGV 0.401786 0.890244
156 CGP 0.4 0.86747
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2UZI; Ligand: GTP; Similar sites found with APoc: 51
This union binding pocket(no: 1) in the query (biounit: 2uzi.bio1) has 26 residues
No: Leader PDB Ligand Sequence Similarity
1 3N5C GDP 5.26316
2 5EE5 GTP 5.26316
3 4RD0 GDP 6.0241
4 5W76 GDP 7.22892
5 4J0Q GDP 9.63855
6 3U6B GDP 10.5769
7 2BVN GNP 10.5769
8 1SKQ GDP 10.8434
9 4KAX GTP 11.4035
10 5W75 GDP 11.5385
11 1R4A GNP 13.7255
12 4NCN GTP 15.6627
13 4TMZ GSP 15.6627
14 1KK1 GNP 19.2308
15 2FH5 GTP 25.9036
16 1YRB GDP 29.5181
17 4DCT GDP 32.5301
18 1FZQ GDP 40.3614
19 4GOJ GNP 40.3614
20 5DI3 GNP 41.5663
21 1GWN GTP 45.7831
22 1M7B GTP 45.7831
23 3M1I GTP 48.1928
24 3WYF GTP 48.1928
25 3WYG GTP 48.1928
26 3GJX GTP 48.1928
27 3GJ4 GDP 48.1928
28 3GJ7 GDP 48.1928
29 3GJ5 GDP 48.1928
30 5UWP GNP 48.7952
31 6CIT GNP 48.7952
32 4HAT GNP 48.7952
33 5UWJ GNP 48.7952
34 5DHF GNP 48.7952
35 5UWR GNP 48.7952
36 5UWI GNP 48.7952
37 5UWQ GNP 48.7952
38 5UWW GNP 48.7952
39 5UWU GNP 48.7952
40 5UWO GNP 48.7952
41 5UWT GNP 48.7952
42 1WA5 GTP 48.7952
43 5UWS GNP 48.7952
44 5UWH GNP 48.7952
45 3RAB GNP 48.7952
46 1Z0J GTP 48.7952
47 1IBR GNP 48.7952
48 5DI9 GNP 48.7952
49 5BXQ GDP 48.7952
50 1YVD GNP 49.3976
51 1NF3 GNP 49.3976
52 5UPK GNP 50
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