Receptor
PDB id Resolution Class Description Source Keywords
2QZT 1.7 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF STEROL CARRIER PROTEIN 2 LIKE 2 (SCP2- L2) FROM AEDES AEGYPTI AEDES AEGYPTI STEROL CARRIER MOSQUITO FATTY ACID PALMITIC ACID CHOLESTEROL LIPID TRANSPORT
Ref.: THREE-DIMENSIONAL STRUCTURE/FUNCTION ANALYSIS OF SCP-2-LIKE2 REVEALS DIFFERENCES AMONG SCP-2 FAMILY MEMBERS. J.LIPID RES. V. 49 644 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PLM A:300;
A:302;
B:301;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
256.424 C16 H32 O2 CCCCC...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2QZT 1.7 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF STEROL CARRIER PROTEIN 2 LIKE 2 (SCP2- L2) FROM AEDES AEGYPTI AEDES AEGYPTI STEROL CARRIER MOSQUITO FATTY ACID PALMITIC ACID CHOLESTEROL LIPID TRANSPORT
Ref.: THREE-DIMENSIONAL STRUCTURE/FUNCTION ANALYSIS OF SCP-2-LIKE2 REVEALS DIFFERENCES AMONG SCP-2 FAMILY MEMBERS. J.LIPID RES. V. 49 644 2008
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 3BDQ - PLM C16 H32 O2 CCCCCCCCCC....
2 2QZT - PLM C16 H32 O2 CCCCCCCCCC....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 3BDQ - PLM C16 H32 O2 CCCCCCCCCC....
2 2QZT - PLM C16 H32 O2 CCCCCCCCCC....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 1PZ4 - PLM C16 H32 O2 CCCCCCCCCC....
2 3BKS - PLM C16 H32 O2 CCCCCCCCCC....
3 3BKR - PLM C16 H32 O2 CCCCCCCCCC....
4 2QZT - PLM C16 H32 O2 CCCCCCCCCC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PLM; Similar ligands found: 52
No: Ligand ECFP6 Tc MDL keys Tc
1 MYR 1 1
2 F23 1 1
3 11A 1 1
4 STE 1 1
5 KNA 1 1
6 TDA 1 1
7 DCR 1 1
8 DAO 1 1
9 DKA 1 1
10 PLM 1 1
11 F15 1 1
12 OCA 0.956522 1
13 SHV 0.833333 0.952381
14 KTC 0.793103 0.875
15 AZ1 0.73913 0.64
16 6NA 0.72 0.904762
17 NER 0.71875 0.954545
18 OLA 0.71875 0.954545
19 ELA 0.71875 0.954545
20 VCA 0.666667 0.954545
21 PAM 0.666667 0.954545
22 PML 0.625 0.6
23 3LA 0.606061 0.8
24 LEA 0.6 0.809524
25 MYZ 0.588235 0.909091
26 12H 0.586207 0.615385
27 ODD 0.567568 0.913043
28 BRC 0.566667 0.666667
29 14V 0.555556 0.740741
30 M12 0.545455 0.869565
31 14U 0.542857 0.703704
32 EIC 0.538462 0.913043
33 EOD 0.538462 0.7
34 BUA 0.48 0.666667
35 RCL 0.468085 0.84
36 HXD 0.459459 0.807692
37 56S 0.459459 0.653846
38 ODT 0.452381 0.782609
39 3X1 0.444444 0.818182
40 LNL 0.44186 0.826087
41 CNS 0.435897 0.68
42 6UL 0.435897 0.68
43 5UF 0.432432 0.807692
44 243 0.428571 0.807692
45 GYM 0.418605 0.606061
46 PL3 0.413793 0.75
47 O8N 0.413793 0.75
48 1DO 0.413793 0.75
49 F09 0.413793 0.75
50 OC9 0.413793 0.75
51 DE1 0.413793 0.75
52 T25 0.403846 0.677419
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2QZT; Ligand: PLM; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2qzt.bio1) has 28 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2QZT; Ligand: PLM; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2qzt.bio1) has 18 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2QZT; Ligand: PLM; Similar sites found: 122
This union binding pocket(no: 3) in the query (biounit: 2qzt.bio1) has 29 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1UO5 PIH 0.006144 0.46838 None
2 4WG0 CHD 0.002585 0.46809 None
3 1UO4 PIH 0.001779 0.45985 None
4 1ZZ7 S0H 0.003247 0.45933 None
5 3KP6 SAL 0.005384 0.44632 None
6 1RL4 BL5 0.01075 0.431 None
7 1TV5 N8E 0.01532 0.43082 None
8 4CCO OGA 0.01289 0.42772 None
9 2AGC MYR 0.01591 0.42542 None
10 2V5E SCR 0.03408 0.42377 None
11 4CCK OGA 0.01648 0.42099 None
12 4CCN OGA 0.01957 0.41704 None
13 1SBR VIB 0.02242 0.41496 None
14 1SLT NDG GAL 0.025 0.41415 None
15 2QL9 CIT 0.01587 0.41364 None
16 4Y3O OGA 0.02226 0.41327 None
17 1MT1 AG2 0.02586 0.41166 None
18 5JF2 SF7 0.007639 0.41139 None
19 4V2O CLQ 0.02519 0.40814 None
20 3RY9 1CA 0.01204 0.40572 None
21 3I0O SMI 0.03904 0.40352 None
22 3GN8 DEX 0.01014 0.40271 None
23 3W54 RNB 0.01958 0.40252 None
24 2HFN FMN 0.01413 0.40252 None
25 2PEH LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.02859 0.40149 None
26 1DB1 VDX 0.005325 0.40015 None
27 4I94 ANP 0.01046 0.41198 1.8018
28 5DG2 GAL GLC 0.006601 0.44945 2.7027
29 1NF8 BOG 0.007538 0.44307 2.7027
30 1GEG GLC 0.02611 0.44077 2.7027
31 3B8I OXL 0.0175 0.41553 2.7027
32 4N14 WR7 0.01533 0.41221 2.7027
33 3G4Q MCH 0.01676 0.40939 2.7027
34 3QP8 HL0 0.01284 0.4078 2.7027
35 1S17 GNR 0.009212 0.40773 2.7027
36 4MGA 27L 0.005836 0.44942 3.6036
37 1A78 TDG 0.01547 0.42948 3.6036
38 4DK7 0KS 0.003438 0.42695 3.6036
39 2QA8 GEN 0.006583 0.42526 3.6036
40 4MGD 27N 0.008231 0.42061 3.6036
41 5J32 IPM 0.02203 0.41709 3.6036
42 3UUD EST 0.01063 0.41528 3.6036
43 1O6U PLM 0.01257 0.41178 3.6036
44 4MGB XDH 0.009811 0.40981 3.6036
45 4WGF HX2 0.02128 0.40713 3.6036
46 1UOU CMU 0.01938 0.40274 3.6036
47 4RW3 PLM 0.01065 0.46912 4.5045
48 4RW3 TDA 0.01031 0.46037 4.5045
49 4MRP GSH 0.03192 0.41942 4.5045
50 4DI8 0GY 0.008816 0.41918 4.5045
51 4DNJ ANN 0.02228 0.41577 4.5045
52 4JGP PYR 0.02456 0.41432 4.5045
53 5F2T PLM 0.00969 0.41354 4.5045
54 4BIX ADP 0.005593 0.44688 5.40541
55 1LQY BB2 0.005432 0.42159 5.40541
56 4BXF AKG 0.02346 0.41403 5.40541
57 5OCA 9QZ 0.03573 0.41195 5.40541
58 4ZXA H8N 0.02291 0.41029 5.40541
59 1ZPD CIT 0.02879 0.40964 5.40541
60 2Q1H AS4 0.009148 0.40787 5.40541
61 3G58 988 0.02796 0.40198 5.40541
62 4DOO DAO 0.02064 0.40141 5.40541
63 1UUY PPI 0.002165 0.48747 6.30631
64 1Q1Y BB2 0.003271 0.4398 6.30631
65 1NRL SRL 0.002053 0.43323 6.30631
66 3CV2 COA 0.01324 0.43299 6.30631
67 1WS1 BB2 0.006503 0.42167 6.30631
68 3KYQ DPV 0.01786 0.42021 6.30631
69 1A05 IPM 0.02417 0.41468 6.30631
70 1G27 BB1 0.00813 0.41017 6.30631
71 5HCN DAO 0.02902 0.40899 6.30631
72 1YC4 43P 0.01159 0.41728 7.20721
73 2XN5 FUN 0.01942 0.41 7.20721
74 4B6C B5U 0.01622 0.40303 7.20721
75 2WH8 II2 0.03209 0.40267 7.20721
76 2Y69 CHD 0.01194 0.43088 7.93651
77 3V1S 0LH 0.03939 0.40307 8.10811
78 4AQL TXC 0.01401 0.40269 8.10811
79 3TDC 0EU 0.01748 0.46554 9.00901
80 1YYE 196 0.004584 0.43279 9.00901
81 4J24 EST 0.006409 0.4299 9.00901
82 4J26 EST 0.007594 0.42629 9.00901
83 3OLL EST 0.005425 0.42535 9.00901
84 1U3R 338 0.007075 0.41633 9.00901
85 2YJD YJD 0.009658 0.41361 9.00901
86 2H12 OAA 0.03105 0.41177 9.00901
87 2OHV NHL 0.02738 0.40626 9.00901
88 1EYQ NAR 0.02892 0.40503 9.00901
89 2YMZ LAT 0.007916 0.43912 9.90991
90 3G5K BB2 0.003744 0.43289 9.90991
91 3A51 VDY 0.009812 0.41329 9.90991
92 2R5V HHH 0.01776 0.40816 9.90991
93 1BYG STU 0.01621 0.40647 9.90991
94 1YRX FMN 0.01727 0.40515 9.90991
95 2HHP FLC 0.0001652 0.53442 10.8108
96 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 0.02187 0.42831 10.8108
97 1Q3A NGH 0.03467 0.40092 10.8108
98 3ZDS OMD 0.04201 0.40038 10.8108
99 4W9F 3JU 0.04068 0.40114 11.5385
100 5FS0 5JC 0.00831 0.43303 11.7117
101 5HCV 60R 0.008918 0.40518 11.7117
102 3N7S 3N7 0.02561 0.41831 12.5
103 4QGE 35O 0.0001424 0.44583 12.6126
104 3TL1 JRO 0.03457 0.40493 12.6126
105 4BKS X6C 0.03591 0.40509 13.4615
106 1M2Z BOG 0.006991 0.43781 13.5135
107 2OKL BB2 0.004766 0.42419 13.5135
108 3ET1 ET1 0.007254 0.41583 13.5135
109 1SO2 666 0.01002 0.41286 13.5135
110 3SP6 IL2 0.01276 0.40136 13.5135
111 1M2Z DEX 0.01104 0.40109 13.5135
112 2YIV NBN 0.0257 0.41011 15.3153
113 3AVS OGA 0.0124 0.42406 16.2162
114 4DR9 BB2 0.003205 0.43605 17.1171
115 1XMY ROL 0.03592 0.40012 17.1171
116 3E3U NVC 0.006598 0.42521 18.018
117 2BCG GER 0.01699 0.41701 19.8198
118 4OB0 PBC 0.03359 0.40568 19.8198
119 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 0.0122 0.43611 25.2252
120 5LX9 OLB 0.01692 0.40558 25.2252
121 3KCG NTP 0.0309 0.40353 25.2252
122 3SAO NKN 0.006429 0.42576 33.3333
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