-->
Receptor
PDB id Resolution Class Description Source Keywords
2Q8M 2.05 Å EC: 3.1.3.11 T-LIKE FRUCTOSE-1,6-BISPHOSPHATASE FROM ESCHERICHIA COLI WIT GLUCOSE 6-PHOSPHATE, AND FRUCTOSE 1,6-BISPHOSPHATE BOUND SHIGELLA BOYDII GLYCOLYSIS GLUCONEOGENESIS BACTERIA CARBOHYDRATE METABOLIDIABETES PROTEIN-PROTEIN INTERACTIONS PROTEOBACTERIA GRANEGATIVE PROTEIN CRYSTALLOGRAPHY HETEROTROPHIC ALLOSTERIREGULATION HYDROLASE
Ref.: STRUCTURE OF INHIBITED FRUCTOSE-1,6-BISPHOSPHATASE ESCHERICHIA COLI: DISTINCT ALLOSTERIC INHIBITION SI AMP AND GLUCOSE 6-PHOSPHATE AND THE CHARACTERIZATIO GLUCONEOGENIC SWITCH. J.BIOL.CHEM. V. 282 24697 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AMP A:341;
B:343;
Valid;
Valid;
none;
none;
Ki = 94 uM
347.221 C10 H14 N5 O7 P c1nc(...
BG6 A:340;
Valid;
none;
Ki ~ 700 uM
260.136 C6 H13 O9 P C([C@...
CL A:350;
A:351;
B:349;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
35.453 Cl [Cl-]
FBP A:344;
B:342;
Valid;
Valid;
none;
none;
ic50 = 6 uM
340.116 C6 H14 O12 P2 C([C@...
MG A:347;
A:348;
B:345;
B:346;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Q8M 2.05 Å EC: 3.1.3.11 T-LIKE FRUCTOSE-1,6-BISPHOSPHATASE FROM ESCHERICHIA COLI WIT GLUCOSE 6-PHOSPHATE, AND FRUCTOSE 1,6-BISPHOSPHATE BOUND SHIGELLA BOYDII GLYCOLYSIS GLUCONEOGENESIS BACTERIA CARBOHYDRATE METABOLIDIABETES PROTEIN-PROTEIN INTERACTIONS PROTEOBACTERIA GRANEGATIVE PROTEIN CRYSTALLOGRAPHY HETEROTROPHIC ALLOSTERIREGULATION HYDROLASE
Ref.: STRUCTURE OF INHIBITED FRUCTOSE-1,6-BISPHOSPHATASE ESCHERICHIA COLI: DISTINCT ALLOSTERIC INHIBITION SI AMP AND GLUCOSE 6-PHOSPHATE AND THE CHARACTERIZATIO GLUCONEOGENIC SWITCH. J.BIOL.CHEM. V. 282 24697 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 11 families.
1 2Q8M Ki = 94 uM AMP C10 H14 N5 O7 P c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 2Q8M Ki = 94 uM AMP C10 H14 N5 O7 P c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2Q8M Ki = 94 uM AMP C10 H14 N5 O7 P c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: AMP; Similar ligands found: 395
No: Ligand ECFP6 Tc MDL keys Tc
1 A 1 1
2 AMP 1 1
3 A2D 0.833333 0.943662
4 ABM 0.833333 0.943662
5 ADP 0.823529 0.971429
6 A12 0.808824 0.931507
7 AP2 0.808824 0.931507
8 BA3 0.808824 0.943662
9 SRA 0.80303 0.944444
10 AP5 0.797101 0.943662
11 B4P 0.797101 0.943662
12 HEJ 0.788732 0.971429
13 ATP 0.788732 0.971429
14 AT4 0.785714 0.931507
15 AN2 0.785714 0.957747
16 5FA 0.777778 0.971429
17 AQP 0.777778 0.971429
18 APC 0.777778 0.931507
19 CA0 0.774648 0.917808
20 M33 0.774648 0.930556
21 AU1 0.774648 0.944444
22 ADX 0.774648 0.848101
23 ACP 0.763889 0.944444
24 50T 0.763889 0.957747
25 25A 0.75641 0.971429
26 AR6 0.753425 0.943662
27 PRX 0.753425 0.917808
28 APR 0.753425 0.943662
29 ACQ 0.746667 0.944444
30 T99 0.746667 0.931507
31 TAT 0.746667 0.931507
32 SAP 0.743243 0.918919
33 AD9 0.743243 0.944444
34 AGS 0.743243 0.918919
35 RBY 0.743243 0.905405
36 ADV 0.743243 0.905405
37 ANP 0.723684 0.944444
38 ADP PO3 0.72 0.942857
39 6YZ 0.717949 0.944444
40 5AL 0.714286 0.930556
41 SON 0.712329 0.931507
42 LMS 0.710145 0.825
43 RAB 0.709677 0.842857
44 XYA 0.709677 0.842857
45 ADN 0.709677 0.842857
46 ATF 0.705128 0.931507
47 GAP 0.701299 0.891892
48 A22 0.7 0.957747
49 SRP 0.696203 0.905405
50 7D5 0.691176 0.902778
51 A3P 0.684932 0.971014
52 A2P 0.684932 0.956522
53 ADP ALF 0.683544 0.868421
54 ALF ADP 0.683544 0.868421
55 ADQ 0.682927 0.917808
56 MAP 0.679012 0.918919
57 ADP VO4 0.675 0.930556
58 VO4 ADP 0.675 0.930556
59 OOB 0.670732 0.930556
60 9ZA 0.670732 0.906667
61 8QN 0.670732 0.930556
62 5SV 0.670732 0.87013
63 9ZD 0.670732 0.906667
64 PTJ 0.670588 0.894737
65 AOC 0.666667 0.84507
66 PAJ 0.662651 0.858974
67 4AD 0.662651 0.893333
68 A3R 0.662651 0.881579
69 A1R 0.662651 0.881579
70 AMO 0.662651 0.905405
71 5N5 0.661538 0.816901
72 DAL AMP 0.658537 0.90411
73 IMO 0.657534 0.928571
74 AHX 0.654762 0.87013
75 00A 0.654762 0.881579
76 DLL 0.654762 0.930556
77 5AS 0.653333 0.776471
78 A4D 0.651515 0.816901
79 5CD 0.651515 0.828571
80 9X8 0.647059 0.893333
81 OAD 0.647059 0.917808
82 3UK 0.647059 0.917808
83 ADP BMA 0.647059 0.891892
84 25L 0.643678 0.957747
85 PR8 0.639535 0.848101
86 WAQ 0.639535 0.881579
87 LAD 0.639535 0.858974
88 B5V 0.639535 0.905405
89 DTA 0.637681 0.808219
90 V3L 0.6375 0.971429
91 3DH 0.633803 0.794521
92 BIS 0.632184 0.906667
93 ME8 0.632184 0.8375
94 3OD 0.632184 0.917808
95 FYA 0.632184 0.930556
96 NB8 0.632184 0.87013
97 1ZZ 0.632184 0.8375
98 TXA 0.632184 0.905405
99 MTA 0.628571 0.794521
100 3AM 0.625 0.956522
101 EP4 0.623188 0.773333
102 A A 0.62069 0.971429
103 9SN 0.617977 0.87013
104 M2T 0.614286 0.753247
105 JB6 0.613636 0.881579
106 YAP 0.611111 0.893333
107 B5Y 0.611111 0.893333
108 FA5 0.611111 0.905405
109 B5M 0.611111 0.893333
110 MYR AMP 0.606742 0.814815
111 G5A 0.604938 0.776471
112 XAH 0.604396 0.8375
113 4UV 0.597826 0.893333
114 71V 0.597403 0.906667
115 ATP A A A 0.593407 0.929577
116 PAP 0.592593 0.957143
117 G3A 0.591398 0.894737
118 2AM 0.589041 0.942857
119 5X8 0.5875 0.783784
120 6RE 0.586667 0.779221
121 6C6 0.585366 0.905405
122 AFH 0.585106 0.858974
123 4UU 0.585106 0.893333
124 G5P 0.585106 0.894737
125 GA7 0.585106 0.905405
126 7D3 0.584416 0.878378
127 A5A 0.583333 0.804878
128 TSB 0.581395 0.795181
129 AMP DBH 0.580645 0.891892
130 TYR AMP 0.580645 0.868421
131 2A5 0.580247 0.891892
132 DQV 0.578947 0.930556
133 DSH 0.578947 0.74359
134 GTA 0.578947 0.860759
135 TAD 0.578947 0.858974
136 6IA 0.578313 0.858974
137 SSA 0.576471 0.776471
138 AMZ 0.575342 0.888889
139 C2R 0.575342 0.876712
140 PGS 0.575 0.857143
141 7D4 0.575 0.878378
142 ZAS 0.573333 0.786667
143 ATR 0.573171 0.942857
144 LAQ 0.572917 0.8375
145 AAM 0.571429 1
146 J7C 0.571429 0.789474
147 A3N 0.571429 0.783784
148 PPS 0.571429 0.848101
149 AIR 0.571429 0.927536
150 52H 0.569767 0.776471
151 54H 0.569767 0.785714
152 VMS 0.569767 0.785714
153 AR6 AR6 0.568421 0.916667
154 ARG AMP 0.568421 0.82716
155 7MD 0.568421 0.8375
156 YLP 0.56701 0.817073
157 48N 0.56701 0.87013
158 OVE 0.565789 0.90411
159 UPA 0.565657 0.881579
160 2SA 0.564706 0.905405
161 S4M 0.564103 0.682353
162 5CA 0.563218 0.776471
163 53H 0.563218 0.776471
164 8X1 0.563218 0.75
165 UP5 0.561224 0.893333
166 NAI 0.561224 0.881579
167 6V0 0.561224 0.87013
168 NAX 0.561224 0.848101
169 4UW 0.561224 0.858974
170 DND 0.561224 0.905405
171 TXD 0.561224 0.881579
172 NXX 0.561224 0.905405
173 NIA 0.56 0.820513
174 D5M 0.558442 0.902778
175 DA 0.558442 0.902778
176 MAO 0.556962 0.777778
177 AHZ 0.556701 0.814815
178 OMR 0.555556 0.82716
179 ITT 0.555556 0.915493
180 TYM 0.555556 0.905405
181 TXE 0.555556 0.881579
182 5AD 0.552239 0.768116
183 A2R 0.551724 0.957747
184 LPA AMP 0.55102 0.814815
185 DSZ 0.550562 0.776471
186 NSS 0.550562 0.776471
187 LSS 0.550562 0.758621
188 AP0 0.55 0.87013
189 YLC 0.55 0.8375
190 4TC 0.55 0.87013
191 YLB 0.55 0.817073
192 P5A 0.549451 0.741573
193 139 0.54902 0.848101
194 A4P 0.544554 0.819277
195 NVA LMS 0.544444 0.75
196 GJV 0.544304 0.769231
197 7D7 0.544118 0.763889
198 9K8 0.543478 0.711111
199 A7D 0.54321 0.797297
200 AF3 ADP 3PG 0.54 0.835443
201 6K6 0.539326 0.957143
202 IOT 0.539216 0.829268
203 A3G 0.538462 0.797297
204 LEU LMS 0.538462 0.75
205 A5D 0.535714 0.808219
206 7MC 0.534653 0.817073
207 T5A 0.533981 0.817073
208 ADJ 0.533981 0.82716
209 YLA 0.533981 0.817073
210 GSU 0.532609 0.776471
211 KAA 0.532609 0.75
212 7RA 0.531646 0.985507
213 SFG 0.53012 0.77027
214 SAH 0.529412 0.763158
215 HFD 0.529412 0.918919
216 AYB 0.528846 0.807229
217 CNA 0.528846 0.905405
218 N6P 0.527473 0.942029
219 8BR 0.525 0.931507
220 F2R 0.52381 0.839506
221 80F 0.523364 0.817073
222 Y3J 0.521127 0.746479
223 YSA 0.520833 0.776471
224 7RP 0.518987 0.955882
225 BTX 0.518868 0.839506
226 NAD 0.518868 0.930556
227 COD 0.518868 0.788235
228 G A A A 0.518868 0.87013
229 MHZ 0.518072 0.714286
230 SA8 0.517647 0.725
231 6AD 0.517241 0.883117
232 DZD 0.514019 0.858974
233 BT5 0.514019 0.829268
234 RMB 0.5125 0.898551
235 SAI 0.511628 0.753247
236 AV2 0.511364 0.890411
237 8PZ 0.510417 0.776471
238 A3D 0.509259 0.917808
239 A3S 0.506024 0.808219
240 3AT 0.505747 0.943662
241 SAM 0.505747 0.707317
242 SMM 0.505618 0.702381
243 NA7 0.505376 0.931507
244 4TA 0.504673 0.804878
245 AMP NAD 0.504673 0.90411
246 EEM 0.5 0.707317
247 G 0.5 0.905405
248 NEC 0.5 0.743243
249 5GP 0.5 0.905405
250 AAT 0.5 0.725
251 YLY 0.495495 0.807229
252 M24 0.495495 0.848101
253 7C5 0.494949 0.815789
254 DAT 0.494118 0.878378
255 A3T 0.494118 0.819444
256 P2P 0.493827 0.928571
257 FAI 0.493827 0.888889
258 1RB 0.493671 0.911765
259 NAE 0.491071 0.893333
260 U A 0.490909 0.906667
261 NAJ PZO 0.490909 0.846154
262 A G 0.490741 0.881579
263 TM1 0.489583 0.771084
264 A A A 0.489362 0.90411
265 A6D 0.489362 0.740741
266 PO4 PO4 A A A A PO4 0.489362 0.901408
267 S7M 0.488889 0.707317
268 DTP 0.488636 0.878378
269 RBZ 0.4875 0.873239
270 101 0.4875 0.902778
271 EAD 0.486957 0.848101
272 NAQ 0.486726 0.87013
273 U A G G 0.486239 0.881579
274 4YB 0.485149 0.758621
275 NDE 0.483051 0.931507
276 ZID 0.482456 0.917808
277 N0B 0.482456 0.817073
278 WSA 0.480769 0.785714
279 RGT 0.479592 0.931507
280 ARU 0.478723 0.835443
281 GGZ 0.478261 0.8
282 JLN 0.47561 0.863014
283 ANZ 0.475248 0.820513
284 QQY 0.475 0.837838
285 ACK 0.475 0.885714
286 NAJ PYZ 0.473684 0.804878
287 S8M 0.473118 0.779221
288 GEK 0.473118 0.734177
289 AVV 0.473118 0.87013
290 3AD 0.472973 0.828571
291 A U 0.471698 0.868421
292 P1H 0.470588 0.82716
293 0UM 0.468085 0.716049
294 RVP 0.467532 0.847222
295 649 0.466667 0.741573
296 Z5A 0.465517 0.776471
297 PMO 0.464286 0.873239
298 SXZ 0.463918 0.707317
299 62X 0.463158 0.682353
300 QQX 0.4625 0.826667
301 8Q2 0.462264 0.75
302 2VA 0.45977 0.797297
303 IMP 0.458824 0.90411
304 K15 0.458333 0.698795
305 CC5 0.458333 0.84058
306 AS 0.457831 0.855263
307 DDS 0.455556 0.851351
308 V1N 0.455446 0.943662
309 NJP 0.454545 0.918919
310 7DD 0.453488 0.957143
311 93A 0.453488 0.804878
312 G7M 0.453488 0.87013
313 3L1 0.453333 0.77027
314 3D1 0.453333 0.77027
315 EO7 0.452381 0.785714
316 NDC 0.45082 0.87013
317 FB0 0.45082 0.781609
318 0WD 0.45045 0.894737
319 NVA 2AD 0.449438 0.75641
320 26A 0.447368 0.76
321 2FA 0.447368 0.810811
322 2BA 0.447059 0.914286
323 CMP 0.447059 0.927536
324 D3Y 0.446809 0.786667
325 KB1 0.444444 0.716049
326 APU 0.444444 0.893333
327 VRT 0.444444 0.766234
328 SO8 0.444444 0.786667
329 FDA 0.443548 0.809524
330 PUA 0.443478 0.858974
331 ODP 0.441441 0.883117
332 6FA 0.44 0.817073
333 103 0.439024 0.861111
334 RP1 0.439024 0.864865
335 SP1 0.439024 0.864865
336 3NZ 0.438776 0.779221
337 A C A C 0.438596 0.846154
338 7DT 0.438202 0.957143
339 NDP 0.436364 0.894737
340 NPW 0.436364 0.860759
341 MTP 0.434211 0.727273
342 FAS 0.433071 0.82716
343 SFD 0.433071 0.712766
344 FAD 0.433071 0.82716
345 IRN 0.432432 0.867647
346 ZZB 0.432432 0.792683
347 TXP 0.432432 0.894737
348 NZQ 0.432432 0.883117
349 62F 0.430769 0.8375
350 FNK 0.430769 0.781609
351 128 0.429907 0.752941
352 1DA 0.428571 0.842857
353 6MD 0.428571 0.805556
354 PAX 0.428571 0.82716
355 SLU 0.426087 0.767442
356 XNP 0.424779 0.848101
357 12D 0.424528 0.761905
358 5F1 0.423077 0.72973
359 ETB 0.422414 0.809524
360 DCA 0.422414 0.8
361 F0P 0.422018 0.725
362 WMP 0.421053 0.864865
363 GUO 0.421053 0.864865
364 FAY 0.416667 0.8375
365 38Y 0.415929 0.804878
366 5J9 0.415842 0.728395
367 COA 0.415254 0.8
368 0T1 0.415254 0.8
369 KH3 0.415094 0.690476
370 U A C C 0.413793 0.857143
371 N01 0.413793 0.90411
372 FMP 0.413793 0.871429
373 RFL 0.413534 0.797619
374 NMN AMP PO4 0.412281 0.868421
375 GP2 0.408602 0.858974
376 GDP 0.408602 0.893333
377 NAP 0.408333 0.944444
378 NOC 0.407895 0.760563
379 2ER 0.405941 0.831169
380 1PR 0.405941 0.820513
381 P5F 0.405797 0.8
382 CAO 0.404959 0.772727
383 TAP 0.404959 0.906667
384 30N 0.404959 0.731183
385 COS 0.404959 0.781609
386 AMX 0.404959 0.809524
387 XMP 0.402299 0.891892
388 G2P 0.402062 0.858974
389 APC G U 0.401709 0.833333
390 U A A U 0.401639 0.906667
391 CMX 0.401639 0.8
392 NA0 0.401639 0.931507
393 SCO 0.401639 0.8
394 9JJ 0.40146 0.8375
395 F2N 0.4 0.790698
Ligand no: 2; Ligand: BG6; Similar ligands found: 61
No: Ligand ECFP6 Tc MDL keys Tc
1 M6D 1 1
2 BG6 1 1
3 G6P 1 1
4 A6P 1 1
5 BGP 1 1
6 M6P 1 1
7 RP5 0.8 0.902439
8 ABF 0.8 0.902439
9 HSX 0.8 0.902439
10 AHG 0.621622 0.795455
11 GLP 0.590909 0.829787
12 4R1 0.590909 0.829787
13 50A 0.571429 0.8
14 RF5 0.571429 0.8
15 16G 0.55102 0.75
16 4QY 0.55102 0.75
17 BMX 0.55102 0.75
18 EMZ 0.55 0.636364
19 GRF 0.547619 0.692308
20 NNG 0.530612 0.75
21 XYT 0.527273 0.906977
22 1FT 0.517857 0.847826
23 FDQ 0.511111 0.777778
24 G16 0.5 0.951219
25 PRP 0.5 0.880952
26 RI2 0.5 0.857143
27 T6P 0.470588 0.906977
28 D6G 0.468085 0.951219
29 P3M 0.466667 0.906977
30 GIV 0.461538 0.675
31 GLC 0.461538 0.675
32 ALL 0.461538 0.675
33 GXL 0.461538 0.675
34 GAL 0.461538 0.675
35 BMA 0.461538 0.675
36 BGC 0.461538 0.675
37 WOO 0.461538 0.675
38 GLA 0.461538 0.675
39 MAN 0.461538 0.675
40 LAK 0.45098 0.674419
41 GLA BGC 0.45098 0.674419
42 MAN MAN 0.45098 0.674419
43 GLC GLC 0.45098 0.674419
44 BGC GLC 0.45098 0.674419
45 MAN BMA 0.45098 0.674419
46 GAL GLC 0.45098 0.674419
47 BMA MAN 0.45098 0.674419
48 BMA GLA 0.45098 0.674419
49 GLA GLC 0.45098 0.674419
50 GLC BGC 0.45098 0.674419
51 GLA BMA 0.45098 0.674419
52 MLB 0.45098 0.674419
53 BGC GLA 0.45098 0.674419
54 GAL GAL 0.45098 0.674419
55 N 0.444444 0.777778
56 PPC 0.442308 0.822222
57 GLC GLC GLC GLC GLC BGC 0.433962 0.674419
58 GLC GLC GLC 0.433962 0.674419
59 MAN MAN MAN 0.433962 0.674419
60 BMA MAN MAN 0.433962 0.674419
61 GLC GLC GLC GLC BGC 0.433962 0.674419
Ligand no: 3; Ligand: FBP; Similar ligands found: 9
No: Ligand ECFP6 Tc MDL keys Tc
1 AFP 1 1
2 FBP 1 1
3 F1X 0.744186 0.954545
4 TA6 0.666667 0.954545
5 F6P 0.666667 0.954545
6 FDP 0.462963 0.954545
7 OI7 0.448276 0.976744
8 F1P 0.418182 0.847826
9 AHG 0.404255 0.930233
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Q8M; Ligand: BG6; Similar sites found with APoc: 2
This union binding pocket(no: 1) in the query (biounit: 2q8m.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 4F06 PHB 3.61446
2 3RV5 DXC 5.61798
Pocket No.: 2; Query (leader) PDB : 2Q8M; Ligand: BG6; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2q8m.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2Q8M; Ligand: FBP; Similar sites found with APoc: 23
This union binding pocket(no: 3) in the query (biounit: 2q8m.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 4IF4 BEF None
2 2C3H GLC GLC None
3 2UYP PPI None
4 2UYN 2KT None
5 4Y4V DAL 1.20482
6 2Z49 AMG 2.10843
7 5L2R MLA 2.40964
8 5NC9 8SZ 2.42915
9 1JP4 AMP 2.5974
10 5H4S RAM 3.52113
11 1KA1 A3P 3.61446
12 1G0H IPD 4.7619
13 2P3V SRT 6.25
14 4D06 X8W 6.71378
15 1LBZ FBP 6.74603
16 5CKS GAL 6.92771
17 5G3L SIA GAL 7.07071
18 6GIU L69 7.22022
19 5CSS G3P 8.84956
20 5EQ8 HSO 10.1083
21 5EYG NAP 10.9434
22 3K0T BGC 13.2867
23 5DJH AMP 14.9306
Pocket No.: 4; Query (leader) PDB : 2Q8M; Ligand: FBP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2q8m.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 2Q8M; Ligand: FBP; Similar sites found with APoc: 3
This union binding pocket(no: 5) in the query (biounit: 2q8m.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 2Z48 NGA 2.10843
2 5HP8 PYR 4.83871
3 5G3L SIA 7.07071
Pocket No.: 6; Query (leader) PDB : 2Q8M; Ligand: FBP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 2q8m.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 2Q8M; Ligand: AMP; Similar sites found with APoc: 368
This union binding pocket(no: 7) in the query (biounit: 2q8m.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 4LHW GNP None
2 2ZJ1 NAD 1.20482
3 2ZJ1 ARJ 1.20482
4 6CB2 OLC 1.36519
5 1BG2 ADP 1.53846
6 4JGT PYR 1.67224
7 5U32 GDP 1.69492
8 5X40 ACP 1.71233
9 4Q1A 2XZ 1.78571
10 4Q1A UDP 1.78571
11 1P72 ADP 1.80723
12 5MZI FYK 1.80723
13 5MW4 5JU 1.80723
14 4IEE AGS 1.80723
15 1OXV ANP 1.80723
16 4UTG ANP 1.80723
17 3UMV FAD 1.80723
18 5TSH ADP 1.80723
19 2VBQ BSJ 1.81818
20 4WQM FAD 1.84049
21 3GAY P6T 1.85759
22 5EOB 5QQ 1.88088
23 1US5 GLU 1.91083
24 2IHU TP9 1.91972
25 2X7I CIT 1.94805
26 3C56 PH4 1.9544
27 3N9R TD3 1.9544
28 3NHB ADP 1.96078
29 2F9L GDP 2.01005
30 1LVG ADP 2.0202
31 1JQ3 AAT 2.02703
32 4ITM ATP 2.10843
33 3R75 PYR 2.10843
34 1VGV UD1 2.10843
35 3EWC MCF 2.10843
36 4AVB ACO 2.10843
37 2GDJ ANP 2.27273
38 3I9U DTU 2.28137
39 2VZZ SCA 2.29358
40 5WDR GNP 2.33918
41 6BA2 7KM 2.37288
42 3QVV A3P 2.37288
43 3QVV 3QV 2.37288
44 4DP3 MMV 2.40964
45 4DP3 NDP 2.40964
46 1J0D 5PA 2.40964
47 4AG5 ADP 2.40964
48 5V2J 7WV 2.40964
49 2QV7 ADP 2.40964
50 1PJS SAH 2.40964
51 2Y65 ADP 2.40964
52 1R0X ATP 2.44755
53 3W5J GDP 2.45098
54 1TAD ALF 2.46914
55 1TAD GDP 2.46914
56 4PYA 2X3 2.48447
57 1J3I NDP 2.5
58 1J3I WRA 2.5
59 1KSK URA 2.5641
60 6CS8 F9Y 2.64026
61 4WBD CIT 2.71084
62 2OG2 MLI 2.71084
63 3QDK QDK 2.71084
64 1ZPD DPX 2.71084
65 4FRZ ADP 2.71084
66 4D9M 0JO 2.71084
67 1GY8 NAD 2.71084
68 1J78 OLA 2.71084
69 4ZKD GDP 2.71084
70 1F9V ADP 2.71084
71 4JNA FAD 2.71084
72 3KJS NAP 2.71084
73 1E2K TMC 2.71903
74 2EVL GAL SPH EIC 2.87081
75 2EIX FAD 2.88066
76 2ZE3 AKG 2.90909
77 2W58 ADP 2.9703
78 3B9Q MLI 2.98013
79 4LAE NAP 2.99401
80 4LAE 1VM 2.99401
81 5NM7 GLY 3.00752
82 1SVK ALF GDP 3.01205
83 6C1R EFD 3.01205
84 2CE7 ADP 3.01205
85 1I36 NAP 3.0303
86 1Y3A GDP 3.03951
87 4TL6 ANP 3.16206
88 1BH2 GSP 3.1746
89 1UJ2 C5P 3.1746
90 1UJ2 ADP 3.1746
91 1AKY AP5 3.18182
92 4P5E N6P 3.28947
93 3KP6 SAL 3.31126
94 5AZC PGT 3.33333
95 2BL9 NDP 3.36134
96 2OFW ADX 3.36538
97 5UGW GSH 3.42857
98 1UKZ ADP 3.44828
99 1JJ7 ADP 3.46154
100 5W6Y TRP 3.48101
101 2J5V PCA 3.61446
102 2NCD ADP 3.61446
103 3ITJ CIT 3.61446
104 3ITJ FAD 3.61446
105 4CNK FAD 3.61446
106 1OS1 ATP 3.61446
107 1OS1 PYR 3.61446
108 1OIX GDP 3.66492
109 3OU2 SAH 3.66972
110 1ZVX FIN 3.68098
111 4MKG AP5 3.68664
112 1ZIN AP5 3.68664
113 5L3S GNP 3.69128
114 1DR1 HBI 3.7037
115 1DR1 NAP 3.7037
116 1RL4 BRR 3.7234
117 4MVK ACE VAL PHE PHE ALA GLU ASP NH2 3.7234
118 4WZ6 ATP 3.7931
119 4E03 ADP 3.8835
120 1G6H ADP 3.89105
121 2PEZ DAT 3.91061
122 2PEZ GGZ 3.91061
123 4PPF FLC 3.91566
124 2VVG ADP 3.91566
125 2BO4 FLC 3.91566
126 5ESO ISC 3.91566
127 5ESO TDP 3.91566
128 1W5T ANP 3.91566
129 5OGX FAD 3.91566
130 4BQS K2Q 3.97727
131 4BQS ADP 3.97727
132 6B8B ADP 4.01606
133 2BES RES 4.06977
134 1FQK GDP 4.08163
135 2XT3 ADP 4.21687
136 3EEL 53T 4.21687
137 3RC3 ANP 4.21687
138 3DC4 ADP 4.21687
139 5OCG GNP 4.2328
140 4KFU ACP 4.24528
141 1ZD9 GDP 4.25532
142 4R2I ANP 4.28571
143 1XP8 AGS 4.37158
144 4YDS ATP 4.38596
145 1U7Z PMT 4.42478
146 3H4S ADP 4.44444
147 1USF NAP 4.49438
148 4U00 ADP 4.5082
149 1YQT ADP 4.51807
150 3LRE ADP 4.51807
151 2NXW TPP 4.51807
152 3NKV GNP 4.57143
153 1B0U ATP 4.58015
154 1JI0 ATP 4.58333
155 4JLS 3ZE 4.60526
156 3A4M ADP 4.61538
157 2FKA BEF 4.65116
158 4KVG GTP 4.7619
159 6BVM GNP 4.79042
160 6D5E GNP 4.79042
161 6BVJ GNP 4.79042
162 6BVL GNP 4.79042
163 6BVK GNP 4.79042
164 6D5J GNP 4.79042
165 6D55 GNP 4.79042
166 6BVI GNP 4.79042
167 6D5M GNP 4.79042
168 6D5G GNP 4.79042
169 6D56 GNP 4.79042
170 6D5L GNP 4.79042
171 6D59 GNP 4.79042
172 6D5H GNP 4.79042
173 6D5V GNP 4.79042
174 2AWN ADP 4.81928
175 4YJ1 ADP 4.81928
176 4JB1 FAD 4.81928
177 3KUD GDP 4.81928
178 4JB1 NAP 4.81928
179 3RLF ANP 4.81928
180 1WQ1 GDP 4.81928
181 3DDC GNP 4.81928
182 1NVV GNP 4.81928
183 1CLU DBG 4.81928
184 5TS5 FAD 4.81928
185 1JXZ BCA 4.83271
186 1NZY BCA 4.83271
187 3QLM PLM 4.83871
188 5LXT GDP 4.8951
189 5LXT 7AK 4.8951
190 3RYC GTP 4.8951
191 5E5U MLI 5.02513
192 3K7S R52 5.02793
193 5UWJ GNP 5.06329
194 5UWI GNP 5.06329
195 5DI9 GNP 5.06329
196 5DIF GNP 5.06329
197 5UWR GNP 5.06329
198 5UWT GNP 5.06329
199 5UWU GNP 5.06329
200 5UWW GNP 5.06329
201 5UWQ GNP 5.06329
202 5DHF GNP 5.06329
203 5UWO GNP 5.06329
204 5UWP GNP 5.06329
205 5UWS GNP 5.06329
206 5UWH GNP 5.06329
207 5ZXD ATP 5.12048
208 1T5C ADP 5.12048
209 2X7J TPP 5.12048
210 5DRB 5FJ 5.15464
211 2AQX ATP 5.19031
212 2D2F ADP 5.2
213 4UNR QZE 5.2381
214 2PZE ATP 5.24017
215 1G0N PHH 5.30035
216 1G0N NDP 5.30035
217 4NTO 1PW 5.31401
218 1VG8 GNP 5.31401
219 5EXW 7DT 5.42169
220 3HWW AKG 5.42169
221 4XMF HSM 5.43478
222 5W4W 9WG 5.43807
223 3HGM ATP 5.44218
224 3WYF GTP 5.47945
225 3M1I GTP 5.47945
226 4MKF AP5 5.52995
227 4HAT GNP 5.55556
228 1IBR GNP 5.55556
229 5ZB0 TYD 5.55556
230 5ZB0 ADP 5.55556
231 3RV5 DXC 5.61798
232 4G86 BNT 5.6338
233 1G8S MET 5.65217
234 4BFW ZVW 5.66038
235 1HTW ADP 5.6962
236 4DE2 DN3 5.70342
237 5WS9 ATP 5.72289
238 2XTZ GSP 5.72289
239 1AOE NDP 5.72917
240 1AOE GW3 5.72917
241 4KBY C2E 5.7971
242 1YZN GNP 5.94595
243 1M48 FRG 6.01504
244 6CUZ FEV 6.0241
245 6AMI TRP 6.0241
246 1IGW PYR 6.0241
247 6AM8 PLT 6.0241
248 1NN5 2DT 6.04651
249 1NN5 ANP 6.04651
250 1G3M PCQ 6.12245
251 1G3M A3P 6.12245
252 1SQS TLA 6.19835
253 3GUZ PAF 6.25
254 3HRD NIO 6.25
255 1CX9 NHP 6.3253
256 3GE7 AFQ 6.3253
257 3ZLR X0B 6.32911
258 6FA4 GNP 6.35838
259 3ZLM ANP 6.38298
260 1HSK FAD 6.44172
261 5H68 AGS 6.47059
262 3AQT RCO 6.53061
263 1GXU 2HP 6.59341
264 1S7N COA 6.59341
265 5YV5 ADP 6.62651
266 2WPX ACO 6.78466
267 1L2T ATP 6.80851
268 1WA5 GTP 6.81818
269 1LFD GNP 6.89655
270 4I4Z 2NE 6.90909
271 2WHX ADP 6.92771
272 4K81 GTP 6.97674
273 2V2V V12 7.01107
274 3RWO GDP 7.02703
275 1UAD GNP 7.07071
276 1GA8 DEL 7.07396
277 1GA8 UPF 7.07396
278 2CBZ ATP 7.173
279 6A20 ADP 7.22892
280 3B5J 12D 7.40741
281 5G41 AP5 7.62332
282 1Z83 AP5 7.65306
283 2F3R G5P 7.72947
284 2RGX AP5 7.76699
285 5WKC TP9 7.83133
286 5WKC AUJ 7.83133
287 4NE2 SH2 7.83133
288 4NE2 ADP 7.83133
289 1S3G AP5 7.8341
290 3QF7 ANP 8
291 3KTA AP5 8.09249
292 2VBF TPP 8.13253
293 1TU3 GNP 8.18713
294 1RRC ADP 8.30565
295 3QKT ANP 8.43373
296 4OI4 ATP 8.43373
297 3GJX GTP 8.49315
298 3ZCB ATP 8.58586
299 4YMU ATP 8.63636
300 2UZI GTP 8.65385
301 6AU6 GDP 8.73494
302 1CS4 GSP 8.73494
303 2ZTS ADP 8.76494
304 4QM7 GTP 8.77193
305 5A96 GTP 8.83534
306 3KO0 TFP 8.91089
307 4KVL PLM 9.03614
308 2F5X ASP 9.29487
309 1E4I NFG 9.33735
310 5GVR LMR 9.40171
311 5NUL FMN 9.42029
312 5XKT GNP 9.5
313 2IXE ATP 9.5941
314 1LVK MNT BEF 9.63855
315 2KIN ADP 9.66387
316 3FB4 AP5 9.72222
317 1V0C KNC 9.90099
318 1V0C ACO 9.90099
319 6CRK GDP 9.93976
320 2MBR FAD 9.93976
321 2MBR EPU 9.93976
322 1GP2 GDP 9.93976
323 4NU0 AP5 10.1382
324 5J1S ATP 10.2113
325 2D0O ADP 10.5422
326 5EW0 3C7 10.6838
327 3CX8 GSP 10.8434
328 1SVM ATP 10.8434
329 1ZCB GDP 10.8434
330 4HI0 GDP 11.0236
331 1U3G THF 11.1111
332 1QF9 ALF 11.3402
333 1QF9 C5P 11.3402
334 1QF9 ADP 11.3402
335 1GOJ ADP 11.4458
336 3TMK T5A 11.5741
337 1WM1 PTB 11.6719
338 4LFL TG6 11.7284
339 3COB ADP 11.747
340 1E96 GTP 11.8227
341 1FQJ GDP 11.9048
342 2HF9 GSP 11.9469
343 4X8O AP5 12.1495
344 5URY PAM 12.3288
345 5XJ7 87O 12.4378
346 1XEX ATP 12.6374
347 1NU4 MLA 13.4021
348 2ODE ALF GDP 13.4752
349 3LN9 FLC 13.6691
350 1GOT GDP 13.6986
351 2B3D FAD 13.7255
352 4KXL 6C6 13.8158
353 5FB3 NDP 13.8554
354 5Z2M GTP 14.4928
355 5O2T GSP 14.9733
356 1N62 MCN 15.6627
357 1N62 FAD 15.6627
358 3X1Z GNP 16.1677
359 1GUA GNP 16.1677
360 4HDO GNP 16.1677
361 2C5L GTP 16.2393
362 1D1G NDP 17.2619
363 3IA4 NDP 17.284
364 3BC1 GNP 17.4359
365 1F2U ATP 18.9189
366 6CIT GNP 19.0476
367 4HDQ GNP 19.2308
368 3WYG GTP 25
Pocket No.: 8; Query (leader) PDB : 2Q8M; Ligand: AMP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 2q8m.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 2Q8M; Ligand: AMP; Similar sites found with APoc: 51
This union binding pocket(no: 9) in the query (biounit: 2q8m.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 4V1F BQ1 None
2 5AK0 8V1 1.80723
3 2R5N RP5 1.80723
4 2R5N TPP 1.80723
5 5ND5 TPP 2.40964
6 5DXV NAP 2.5641
7 1U0J ADP 2.62172
8 3WQQ IB3 2.71084
9 3WQQ NDP 2.71084
10 3UZO GLU 3.01205
11 1RM6 PCD 3.10559
12 1REO FAD 3.31325
13 1YY5 FAD 3.31325
14 2ZR9 DTP 3.31325
15 2G86 UMP 3.48101
16 2WTN FER 3.58566
17 3ETG GTP 3.61446
18 4ITU 1HS 3.71747
19 1Y1P NMN AMP PO4 3.91566
20 4IAE 1DX 4.2328
21 2J9L ATP 4.32432
22 4QYS PLP SEP 4.52489
23 4QYS PLR 4.52489
24 4MPO AMP 4.57516
25 3RAB GNP 4.73373
26 1Z2A GDP 4.7619
27 6CEP OXM 4.81928
28 6CEP NAD 4.81928
29 4OR7 NAP 4.84848
30 4M7V RAR 5.14286
31 1GAR U89 5.18868
32 4UX9 ANP 5.42169
33 2BEK ATP 5.44747
34 4B9E FAH 5.64784
35 2PI8 NAG NAG NAG NAG NAG NAG 5.72289
36 4ZCC FAD 5.72289
37 1GPE FAD 6.3253
38 3EYA FAD 6.3253
39 3CQL NAG 6.58436
40 2NT8 ATP 6.72646
41 2CIG 1DG 7.54717
42 3CI3 3PO 7.73196
43 3CI3 5AD 7.73196
44 5D6J ATP 8.10811
45 3K7M FAD 8.13253
46 3T6E UQ9 8.13953
47 1MT1 AG2 9.61539
48 5WUU 7UU 17.9856
49 3ZS9 ADP ALF 18.4211
50 2Y69 CHD 18.5714
51 1MJH ATP 20.3704
Pocket No.: 10; Query (leader) PDB : 2Q8M; Ligand: AMP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 10) in the query (biounit: 2q8m.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
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