Receptor
PDB id Resolution Class Description Source Keywords
2Q7D 1.6 Å EC: 2.7.1.134 CRYSTAL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATE 5/6- (ITPK1) IN COMPLEX WITH AMPPNP AND MN2+ HOMO SAPIENS INOSITOL INOSITOL KINASE KINASE ITPK1 INOSITOL 134-5/6PHOSPHATE INOSITOL PHOSPHATE INOSITOLPHOSPHATE POLYPHOSPTRANSFERASE
Ref.: INTEGRATION OF INOSITOL PHOSPHATE SIGNALING PATHWAY HUMAN ITPK1. J.BIOL.CHEM. V. 282 28117 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP A:917;
B:918;
Valid;
Valid;
none;
none;
submit data
506.196 C10 H17 N6 O12 P3 c1nc(...
MN A:901;
A:902;
B:903;
B:904;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
54.938 Mn [Mn+2...
SO4 A:907;
A:908;
A:911;
A:912;
A:914;
A:915;
A:916;
B:905;
B:906;
B:909;
B:910;
B:913;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Q7D 1.6 Å EC: 2.7.1.134 CRYSTAL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATE 5/6- (ITPK1) IN COMPLEX WITH AMPPNP AND MN2+ HOMO SAPIENS INOSITOL INOSITOL KINASE KINASE ITPK1 INOSITOL 134-5/6PHOSPHATE INOSITOL PHOSPHATE INOSITOLPHOSPHATE POLYPHOSPTRANSFERASE
Ref.: INTEGRATION OF INOSITOL PHOSPHATE SIGNALING PATHWAY HUMAN ITPK1. J.BIOL.CHEM. V. 282 28117 2007
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2Q7D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 2QB5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2Q7D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 2QB5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2Q7D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 2QB5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 358
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 B4P 0.802632 0.945205
4 ADP 0.802632 0.972222
5 AP5 0.802632 0.945205
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 ATP 0.772152 0.972222
9 AN2 0.769231 0.986111
10 AQP 0.7625 0.972222
11 5FA 0.7625 0.972222
12 M33 0.759494 0.932432
13 MAP 0.752941 0.972973
14 ACP 0.75 0.945946
15 APR 0.740741 0.945205
16 AR6 0.740741 0.945205
17 ACQ 0.73494 0.945946
18 AD9 0.731707 0.945946
19 SAP 0.731707 0.921053
20 AGS 0.731707 0.921053
21 AMP 0.723684 0.944444
22 A 0.723684 0.944444
23 ATF 0.717647 0.933333
24 ADX 0.716049 0.851852
25 CA0 0.716049 0.92
26 50T 0.707317 0.932432
27 PRX 0.698795 0.87013
28 ABM 0.696203 0.893333
29 AMP MG 0.683544 0.868421
30 AP2 0.679012 0.933333
31 A12 0.679012 0.933333
32 APC 0.678571 0.933333
33 TAT 0.674419 0.933333
34 A22 0.674157 0.958904
35 SRA 0.670886 0.894737
36 SRP 0.670455 0.883117
37 5AL 0.666667 0.906667
38 ADQ 0.659341 0.92
39 A1R 0.659341 0.884615
40 ADP MG 0.654762 0.881579
41 3OD 0.648936 0.92
42 BIS 0.648936 0.909091
43 5SV 0.648352 0.82716
44 BEF ADP 0.647059 0.858974
45 ADP BEF 0.647059 0.858974
46 OAD 0.645161 0.92
47 25L 0.642105 0.958904
48 AMO 0.641304 0.907895
49 G5P 0.636364 0.897436
50 DLL 0.634409 0.906667
51 AHX 0.634409 0.897436
52 00A 0.634409 0.860759
53 ANP MG 0.633333 0.921053
54 ADV 0.632184 0.907895
55 ADP PO3 0.632184 0.917808
56 RBY 0.632184 0.907895
57 NB8 0.631579 0.897436
58 25A 0.630435 0.945205
59 8QN 0.630435 0.906667
60 OOB 0.630435 0.906667
61 G3A 0.626263 0.897436
62 ATP MG 0.625 0.881579
63 4AD 0.623656 0.896104
64 PAJ 0.623656 0.8625
65 LAD 0.621053 0.839506
66 1ZZ 0.614583 0.819277
67 TXA 0.614583 0.907895
68 ME8 0.614583 0.819277
69 GTA 0.613861 0.864198
70 3UK 0.610526 0.894737
71 SON 0.604651 0.907895
72 ADP ALF 0.604396 0.848101
73 ALF ADP 0.604396 0.848101
74 WAQ 0.604167 0.860759
75 PR8 0.604167 0.829268
76 4UV 0.6 0.871795
77 GAP 0.6 0.87013
78 FYA 0.597938 0.881579
79 PTJ 0.597938 0.873418
80 ADP VO4 0.597826 0.906667
81 VO4 ADP 0.597826 0.906667
82 UP5 0.596154 0.896104
83 YAP 0.59596 0.871795
84 FA5 0.59596 0.883117
85 PAP 0.595506 0.958333
86 A4P 0.59434 0.823529
87 XAH 0.59 0.841463
88 4UU 0.588235 0.871795
89 AFH 0.588235 0.8625
90 9SN 0.585859 0.85
91 2A5 0.58427 0.894737
92 T5A 0.583333 0.821429
93 NAI 0.580952 0.884615
94 ITT 0.579545 0.917808
95 ATR 0.577778 0.944444
96 OMR 0.575472 0.831325
97 5AS 0.574713 0.781609
98 YLP 0.571429 0.8
99 48N 0.571429 0.873418
100 AP0 0.570093 0.873418
101 4TC 0.570093 0.873418
102 7D3 0.569767 0.881579
103 ADJ 0.568807 0.831325
104 GNP 0.568421 0.922078
105 DAL AMP 0.568421 0.881579
106 NXX 0.566038 0.907895
107 TXD 0.566038 0.884615
108 NAX 0.566038 0.851852
109 4UW 0.566038 0.839506
110 6V0 0.566038 0.873418
111 DND 0.566038 0.907895
112 XYA 0.565789 0.821918
113 ADN 0.565789 0.821918
114 RAB 0.565789 0.821918
115 AOC 0.564706 0.8
116 7D4 0.561798 0.881579
117 ADP BMA 0.561224 0.894737
118 TXE 0.560748 0.884615
119 TYM 0.560748 0.883117
120 YLB 0.555556 0.8
121 YLC 0.555556 0.819277
122 139 0.554545 0.851852
123 5N5 0.551282 0.797297
124 JB6 0.55 0.860759
125 LAQ 0.54717 0.819277
126 MYR AMP 0.544554 0.797619
127 A4D 0.544304 0.797297
128 5CD 0.544304 0.783784
129 7MD 0.542857 0.864198
130 6AD 0.542553 0.886076
131 A2R 0.541667 0.958904
132 UPA 0.541284 0.884615
133 YLA 0.540541 0.8
134 A A 0.54 0.918919
135 COD 0.539823 0.793103
136 BTX 0.539823 0.821429
137 G5A 0.537634 0.781609
138 CNA 0.535714 0.907895
139 AYB 0.535714 0.790698
140 3DH 0.535714 0.753247
141 BT5 0.535088 0.811765
142 ATP A A A 0.533981 0.905405
143 IOT 0.531532 0.811765
144 MTA 0.53012 0.753247
145 3AM 0.529412 0.90411
146 A3P 0.52809 0.944444
147 NAD 0.526316 0.906667
148 PPS 0.526316 0.851852
149 EP4 0.52439 0.734177
150 7D5 0.52381 0.855263
151 AMP DBH 0.52381 0.87013
152 J7C 0.522727 0.75
153 A5A 0.520833 0.809524
154 EAD 0.520661 0.851852
155 TSB 0.520408 0.821429
156 AHZ 0.518519 0.797619
157 M2T 0.518072 0.716049
158 DTA 0.518072 0.766234
159 A3D 0.517241 0.894737
160 6RE 0.517241 0.740741
161 YLY 0.516949 0.790698
162 SSA 0.515464 0.802326
163 NA7 0.514852 0.933333
164 TYR AMP 0.514286 0.858974
165 AR6 AR6 0.514019 0.893333
166 7MC 0.513514 0.843373
167 A2P 0.511111 0.930556
168 52H 0.510204 0.781609
169 VMS 0.510204 0.790698
170 54H 0.510204 0.790698
171 TAD 0.509259 0.8625
172 NAQ 0.508333 0.85
173 A3N 0.505618 0.766234
174 AV2 0.505155 0.893333
175 5CA 0.50505 0.802326
176 53H 0.50505 0.781609
177 ARU 0.504951 0.839506
178 ARG AMP 0.504587 0.809524
179 ZID 0.504132 0.894737
180 P1H 0.504 0.831325
181 3AT 0.5 0.945205
182 NAE 0.5 0.871795
183 AVV 0.5 0.873418
184 P5A 0.495146 0.747253
185 DSZ 0.49505 0.802326
186 LSS 0.49505 0.764045
187 NSS 0.49505 0.802326
188 N0B 0.491803 0.8
189 AF3 ADP 3PG 0.491071 0.817073
190 LA8 ALF 3PG 0.491071 0.817073
191 ALF ADP 3PG 0.491071 0.817073
192 NVA LMS 0.490196 0.764045
193 DAT 0.489362 0.881579
194 IMO 0.488889 0.90411
195 ZAS 0.488636 0.792208
196 FDA 0.488372 0.813953
197 NAJ PZO 0.487395 0.85
198 4TA 0.487179 0.788235
199 LPA AMP 0.486486 0.797619
200 LEU LMS 0.485437 0.764045
201 DTP 0.484536 0.881579
202 V3L 0.484536 0.945205
203 GJV 0.483516 0.731707
204 S4M 0.483516 0.651685
205 DZD 0.483051 0.8625
206 2AM 0.482759 0.917808
207 5AD 0.481013 0.726027
208 KAA 0.480769 0.755556
209 GSU 0.480769 0.781609
210 NDE 0.480315 0.907895
211 M24 0.479339 0.851852
212 MAO 0.478261 0.761905
213 DSH 0.477778 0.707317
214 NEC 0.477778 0.727273
215 FAD 0.477273 0.831325
216 FAS 0.477273 0.831325
217 RGT 0.476636 0.933333
218 0WD 0.474576 0.897436
219 G A A A 0.474576 0.85
220 FNK 0.474074 0.786517
221 5X8 0.473684 0.74359
222 6FA 0.473282 0.821429
223 FB0 0.472868 0.786517
224 NDC 0.472868 0.85
225 YSA 0.472222 0.781609
226 7DD 0.468085 0.958333
227 OVE 0.466667 0.881579
228 NAD IBO 0.466102 0.848101
229 MHZ 0.463158 0.701149
230 A3G 0.461538 0.779221
231 6C6 0.459184 0.858974
232 U A G G 0.458333 0.860759
233 SFG 0.458333 0.730769
234 7D7 0.45679 0.723684
235 128 0.45614 0.8
236 SFD 0.455224 0.736842
237 DDS 0.454545 0.855263
238 GDP 0.454545 0.896104
239 6IA 0.454545 0.817073
240 NJP 0.453782 0.921053
241 ODP 0.453782 0.886076
242 7DT 0.453608 0.958333
243 A7D 0.452632 0.75641
244 Z5A 0.452381 0.802326
245 WSA 0.452174 0.790698
246 7C5 0.45045 0.797468
247 FAY 0.449275 0.841463
248 NDP 0.449153 0.897436
249 A5D 0.44898 0.766234
250 SA8 0.44898 0.690476
251 NAJ PYZ 0.448 0.851852
252 71V 0.446809 0.884615
253 GGZ 0.446602 0.804878
254 RFL 0.446043 0.802326
255 2SA 0.445545 0.907895
256 AMP NAD 0.444444 0.858974
257 GP3 0.444444 0.897436
258 SAI 0.444444 0.716049
259 SAH 0.444444 0.725
260 A A A 0.443396 0.881579
261 PO4 PO4 A A A A PO4 0.443396 0.878378
262 4YB 0.442478 0.764045
263 GTP 0.441176 0.896104
264 SMM 0.441176 0.670455
265 S7M 0.441176 0.674419
266 Y3J 0.440476 0.706667
267 SAM 0.44 0.674419
268 649 0.439655 0.747253
269 12D 0.438596 0.809524
270 A3S 0.4375 0.789474
271 NPW 0.436975 0.864198
272 GCP 0.436893 0.873418
273 AAT 0.435644 0.690476
274 EEM 0.435644 0.674419
275 GNH 0.435644 0.909091
276 DCA 0.435484 0.804598
277 ETB 0.435484 0.813953
278 N6P 0.433962 0.890411
279 TXP 0.433333 0.897436
280 NZQ 0.433333 0.886076
281 PGS 0.43299 0.860759
282 APU 0.432203 0.871795
283 PUA 0.432 0.8625
284 62F 0.431655 0.841463
285 F2N 0.431507 0.795455
286 DA 0.430108 0.855263
287 D5M 0.430108 0.855263
288 J7V 0.429688 0.813953
289 NIA 0.428571 0.848101
290 6K6 0.428571 0.905405
291 A3T 0.428571 0.8
292 0T1 0.428571 0.804598
293 COA 0.428571 0.804598
294 P5F 0.427586 0.804598
295 AAM 0.425532 0.944444
296 0UM 0.424528 0.682353
297 G1R 0.423077 0.884615
298 AMZ 0.422222 0.891892
299 C2R 0.422222 0.88
300 A U 0.420168 0.848101
301 IDP 0.42 0.894737
302 GSP 0.419048 0.851852
303 COS 0.418605 0.786517
304 CAO 0.418605 0.777778
305 AMX 0.418605 0.813953
306 30N 0.418605 0.736842
307 DG1 0.418605 0.897436
308 1DG 0.418605 0.897436
309 TM1 0.418182 0.797619
310 A6D 0.416667 0.746988
311 K15 0.416667 0.666667
312 V1N 0.415929 0.893333
313 SCO 0.415385 0.804598
314 CMX 0.415385 0.804598
315 GEK 0.415094 0.719512
316 NHD 0.414634 0.881579
317 XNP 0.414634 0.851852
318 AIR 0.413793 0.876712
319 COK 0.413534 0.786517
320 G2R 0.412844 0.8625
321 FCX 0.412214 0.777778
322 FAM 0.412214 0.786517
323 ACO 0.412214 0.777778
324 NAP 0.410853 0.92
325 CNV FAD 0.409722 0.775281
326 FA9 0.409396 0.843373
327 SXZ 0.409091 0.694118
328 HAX 0.409091 0.806818
329 PLP AAD 0.408 0.744444
330 TAP 0.407692 0.884615
331 2MC 0.407407 0.752688
332 62X 0.407407 0.651685
333 GKE 0.40708 0.8625
334 GDD 0.40708 0.8625
335 GDC 0.40708 0.8625
336 FYN 0.406015 0.804598
337 3KK 0.406015 0.786517
338 U G A 0.405797 0.819277
339 NA0 0.40458 0.907895
340 101 0.404255 0.855263
341 G 0.40404 0.883117
342 5GP 0.40404 0.883117
343 MGP 0.403846 0.8625
344 MCD 0.402985 0.786517
345 OXK 0.402985 0.786517
346 CA6 0.402985 0.714286
347 SOP 0.402985 0.786517
348 3AD 0.402299 0.783784
349 S8M 0.401869 0.78481
350 YE1 0.40146 0.795455
351 1VU 0.4 0.777778
352 2VA 0.4 0.779221
353 CMC 0.4 0.786517
354 7RP 0.4 0.902778
355 GMV 0.4 0.873418
356 6G0 0.4 0.8625
357 CO6 0.4 0.786517
358 NMX 0.4 0.782609
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found: 179
This union binding pocket(no: 1) in the query (biounit: 2q7d.bio3) has 27 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3V4S ATP 0.000002063 0.50972 1.44509
2 3V4S ADP 0.00003139 0.49921 1.44509
3 5UOX 8GY 0.003056 0.41917 1.47601
4 4XLI 1N1 0.002803 0.43574 1.49254
5 3DLS ADP 0.0002268 0.40743 1.49254
6 2PYW ADP 0.0001885 0.43419 1.7341
7 3WVR AMP 0.00006884 0.42495 1.7341
8 3MVH WFE 0.002385 0.41549 1.75439
9 4JR7 GNP 0.000154 0.42602 1.87166
10 4U98 ACP 0.000003906 0.56799 2.02312
11 3X01 AMP 0.0002173 0.52088 2.02312
12 5I35 ANP 0.0003036 0.48046 2.02312
13 5TDF ADP 0.00004258 0.45429 2.02312
14 4XH0 ADP 0.004012 0.45188 2.02312
15 5AWM ANP 0.00779 0.42713 2.02312
16 2PVN P63 0.001366 0.42371 2.02312
17 4YZC STU 0.007136 0.40476 2.02312
18 3E8N ATP 0.004768 0.41819 2.05279
19 5A6N U7E 0.001248 0.40411 2.12014
20 3LXN MI1 0.001039 0.40642 2.20126
21 5HVJ ANP 0.003946 0.45432 2.22222
22 4D4U FUC GAL 0.00652 0.42443 2.22222
23 4D4U FUC 0.02648 0.40171 2.22222
24 1AUX AGS 0.00002186 0.45576 2.2508
25 1I7L ATP 0.00001203 0.49268 2.26537
26 4RDL FUC GAL NDG FUC 0.01097 0.43234 2.27273
27 4ZS4 ATP 0.001794 0.43651 2.28013
28 2IO8 ADP 0.000001477 0.52643 2.31214
29 2R7K AMZ 0.0003252 0.4486 2.31214
30 5CKW ANP 0.00009233 0.41402 2.31214
31 4GJ3 0XP 0.002635 0.41515 2.31788
32 5C03 AGS 0.0004098 0.46958 2.33918
33 5AIG VPR 0.00997 0.42179 2.4
34 4AXD ANP 0.001973 0.42788 2.41228
35 3G5D 1N1 0.00892 0.41418 2.44755
36 4NW6 2NS 0.001088 0.43206 2.47678
37 1TQP ATP 0.000282 0.44009 2.48227
38 2Z7R STU 0.001331 0.40743 2.49221
39 4WOV 3SM 0.001592 0.45637 2.52366
40 5VCV 1N1 0.004571 0.40552 2.57235
41 3K5I AIR 0.0002646 0.45693 2.60116
42 3K5I ADP 0.00005468 0.45601 2.60116
43 4OCJ NDG 0.002729 0.42205 2.60116
44 2PUL ACP 0.0002323 0.41835 2.60116
45 4OCV ANP 0.0004005 0.41554 2.60116
46 4CLI 5P8 0.008277 0.40712 2.75229
47 3TKI S25 0.01477 0.40314 2.78638
48 2HY0 306 0.01742 0.40586 2.79503
49 3ETH ATP 0.000001648 0.51257 2.89017
50 5DXT 5H5 0.00004492 0.45062 2.89017
51 2VQD AP2 0.000182 0.43823 2.89017
52 4AZW ATP 0.0003286 0.42267 2.89017
53 2V2V V12 0.008331 0.407 2.95203
54 5HX8 66P 0.001503 0.41891 2.98013
55 3W0O ADP 0.001289 0.42622 3.17919
56 4CQB MLI 0.01844 0.42113 3.17919
57 5C4L 4XR 0.002497 0.41609 3.17919
58 3W0O HY0 0.001289 0.40669 3.17919
59 5C4L SIS 0.004959 0.40406 3.17919
60 3RI1 3RH 0.001987 0.41412 3.19489
61 4R78 AMP 0.002914 0.45341 3.23625
62 3PE2 E1B 0.001497 0.44045 3.2641
63 5IH9 6BF 0.001594 0.42927 3.28358
64 4KBA 1QM 0.002607 0.45587 3.32326
65 2AQX ATP 0.0001949 0.43838 3.46021
66 2V58 LZJ 0.0005913 0.45646 3.46821
67 3VOT ADP 0.00001781 0.43886 3.46821
68 5X8I SQZ 0.00597 0.41682 3.46821
69 5LI9 ACP 0.007698 0.40839 3.46821
70 5MY8 RXZ 0.002897 0.40405 3.46821
71 4WNP 3RJ 0.001954 0.45205 3.48432
72 5KO1 6UY 0.004073 0.42822 3.53357
73 1PK8 ATP 0.00002318 0.48611 3.5545
74 4ANW O92 0.0000896 0.47596 3.75723
75 5BVE 4VG 0.005845 0.42588 3.75723
76 4L3L 5FI 0.003007 0.41145 3.94737
77 3KAL ADP 0.00004206 0.49089 4.04624
78 5VZ0 ADP 0.00002828 0.45014 4.04624
79 3TII ANP 0.000006919 0.44703 4.04624
80 5NCY 8TK 0.0001196 0.44506 4.04624
81 4IX4 ADP 0.0001381 0.43651 4.04624
82 4WB6 ATP 0.000893 0.42785 4.04624
83 4Y0X ADP 0.00007552 0.42577 4.04624
84 1RE8 BD2 0.003626 0.42417 4.04624
85 2QCS ANP 0.001256 0.42199 4.04624
86 5T8O 76Z 0.006522 0.40828 4.04624
87 1XJD STU 0.001697 0.43758 4.05797
88 2GU8 796 0.006002 0.42165 4.1543
89 3RE4 TO1 0.0005239 0.4101 4.26357
90 1IA9 ANP 0.0003107 0.42178 4.28571
91 4XYM A12 0.00004223 0.44945 4.31034
92 2VPQ ANP 0.0000182 0.48177 4.33526
93 1KJ8 GAR 0.0001208 0.47801 4.33526
94 1KJ8 ATP 0.0001118 0.47801 4.33526
95 1EHI ADP 0.0001503 0.4321 4.33526
96 4UX9 ANP 0.00309 0.42242 4.33526
97 4GYI ADP 0.0002678 0.40549 4.33526
98 1GSA ADP 0.000006761 0.49596 4.43038
99 4BHN BH9 0.003957 0.41774 4.49102
100 5H2U 1N1 0.009164 0.41186 4.49438
101 5DA3 58V 0.02497 0.40184 4.5283
102 3VPB ADP 0.00003759 0.4785 4.60993
103 3VPC ADP 0.0001085 0.4468 4.60993
104 3DNT ATP 0.001251 0.4154 4.62428
105 5FI4 5XV 0.0002052 0.44514 4.64396
106 3HAV ATP 0.002061 0.41349 4.68227
107 1W2D 4IP 0.004131 0.40451 4.90566
108 2YAK OSV 0.003147 0.41065 4.91228
109 4UWH JXM 0.00001018 0.45305 4.91329
110 4ZGP ADP 0.0001247 0.42155 5.11945
111 4N70 2HX 0.00266 0.43177 5.18293
112 3FHI ANP 0.001233 0.42231 5.19481
113 2YW2 ATP 0.000004668 0.54504 5.20231
114 3WO0 ALA 0.0001327 0.47632 5.20231
115 3NJ4 AFX 0.03207 0.41504 5.20231
116 4O4F ATP 0.0008706 0.43161 5.24194
117 4O4F IHP 0.0009031 0.42766 5.24194
118 4YMJ 4EJ 0.001064 0.48337 5.26316
119 4CC6 L5Y 0.0001152 0.5248 5.34591
120 3CY2 MB9 0.0007312 0.44184 5.41401
121 5DMZ ADP 0.009311 0.40471 5.49133
122 5IQD RIO 0.0008526 0.44294 5.57377
123 5IQD GNP 0.0007954 0.44294 5.57377
124 5U6C 7YS 0.00671 0.40459 5.71429
125 5HCY 60D 0.002819 0.42684 5.74018
126 5EFC GTP 0.02212 0.4123 5.74713
127 5W2I ADP 0.0004943 0.4301 5.83658
128 5W2I I3P 0.0004943 0.4301 5.83658
129 4F4P 0SB 0.01245 0.41005 5.86081
130 5DZT AMP 0.000001144 0.43446 6.35838
131 2QF7 AGS 0.001732 0.41807 6.35838
132 2CSN CKI 0.0015 0.41895 6.39731
133 4E1Z 0MX 0.00103 0.43561 6.52921
134 1VJY 460 0.002328 0.41868 6.60066
135 5LPZ ADP 0.0005563 0.46356 6.92771
136 2JLD AG1 0.002041 0.42232 6.93642
137 4NZN 2OU 0.0000001506 0.47255 6.9697
138 4NZN ANP 0.0000001506 0.47255 6.9697
139 3KRR DQX 0.005851 0.42725 7.11864
140 4Y8D 49J 0.00276 0.43203 7.14286
141 3IDB ANP 0.0004489 0.42733 7.45342
142 5MW8 ATP 0.0003258 0.43343 7.51445
143 5C1P DAL DAL 0.0003813 0.4383 7.51634
144 5C1P ADP 0.00001893 0.43462 7.51634
145 1E4E ADP 0.0001072 0.44004 7.58017
146 5HQ0 LZ9 0.005181 0.41264 7.61589
147 5LXT ACP 0.0000002607 0.58589 7.80347
148 4ME6 ADP 0.00005407 0.40304 7.80347
149 3C0G 3AM 0.001387 0.45928 7.97721
150 2HGS ADP 0.00001712 0.48085 8.3815
151 1M0W ANP 0.000005083 0.46538 8.3815
152 4OTH DRN 0.005407 0.40859 8.5044
153 3LXK MI1 0.003988 0.40366 8.56269
154 1T36 ADP 0.0002822 0.44936 8.67052
155 2XMY CDK 0.007373 0.42349 8.72483
156 3AKK ADP 0.0005774 0.40888 9.23077
157 5NBW 8SK 0.02063 0.40227 9.34579
158 4PU5 ANP 0.002116 0.403 9.53757
159 4WTV ATP 0.0134 0.40083 10.4046
160 4XV1 904 0.00558 0.40454 10.6164
161 4X7Q 3YR 0.003509 0.4273 10.6936
162 4CQE CQE 0.008773 0.40104 11.1511
163 2QK4 ATP 0.00004905 0.40484 12.1387
164 3VPD ANP 0.0000001365 0.55459 12.8114
165 4OFG PCG 0.01678 0.40666 13.8889
166 4Q5H ANP 0.0005417 0.40995 14.4737
167 4WW7 AMP 0.0003739 0.42606 16.5775
168 5USZ SKE 0.002596 0.40511 17.301
169 3ORQ ADP 0.000005096 0.49001 21.3873
170 3ZRM ZRM 0.0007158 0.40317 21.875
171 1IOW PHY 0.00005407 0.48801 23.2026
172 1IOW ADP 0.00005407 0.43754 23.2026
173 5K2M ADP 0.000001205 0.5314 24.5283
174 4NM5 ADP 0.004666 0.40818 25
175 2A19 ANP 0.001391 0.46433 25.7143
176 5N18 8HZ 0.01763 0.41628 28.4404
177 4OH4 ANP 0.0006457 0.4043 28.5714
178 1Z2P I3S 0.000000000009895 0.62091 45.0617
179 1Z2P ACP 0.000000000009895 0.62091 45.0617
Pocket No.: 2; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2q7d.bio3) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found: 38
This union binding pocket(no: 3) in the query (biounit: 2q7d.bio1) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2X4Z X4Z 0.007019 0.4071 1.68919
2 2XVD AS6 0.006447 0.40226 1.98676
3 3OFM 4B0 0.0006348 0.40059 2.02312
4 4E93 GUI 0.005711 0.40844 2.31214
5 5IGI GMP 0.007873 0.40726 2.32558
6 5IGI ZIT 0.008347 0.40726 2.32558
7 5TO8 7FM 0.007155 0.4112 2.48227
8 4DFU QUE 0.0001489 0.41014 2.60116
9 1E8G FCR 0.009936 0.40898 2.60116
10 4P5Z Q7M 0.01117 0.40181 2.60116
11 3TM0 ANP 0.007261 0.40405 2.6616
12 3TM0 B31 0.007764 0.40405 2.6616
13 4BTK DTQ 0.001891 0.40032 2.67062
14 2IF8 ADP 0.000131 0.41152 2.75482
15 1Q8Y ADE 0.0001534 0.40819 2.89017
16 5W4W 9WG 0.005984 0.4063 3.32326
17 1CM8 ANP 0.001134 0.40254 3.46821
18 4Y9T PA1 0.0213 0.41175 3.75723
19 4H3Q ANP 0.003931 0.40178 3.75723
20 3PN1 IVH 0.00005501 0.40464 3.77358
21 4USF 6UI 0.005131 0.40031 3.94737
22 4F9C 0SX 0.000873 0.40668 4.04624
23 2R85 AMP 0.008389 0.40015 4.19162
24 4GLW 0XT 0.0001111 0.41117 4.2623
25 3I0O ADP 0.0003956 0.40317 4.42478
26 1OBD ATP 0.0003395 0.40891 4.90196
27 3TPV ADE 0.001808 0.40058 5.20231
28 4KS7 X4Z 0.00218 0.41213 6.16438
29 1Y57 MPZ 0.002289 0.41066 6.35838
30 3F7Z 34O 0.0009428 0.40949 6.93642
31 5JP0 BGC 0.03125 0.40188 7.51445
32 4NJH 2K8 0.0047 0.412 7.82609
33 2V7O DRN 0.0002622 0.40244 8.03571
34 3NW7 LGV 0.01714 0.40036 8.46906
35 3KMW ATP 0.00101 0.40136 9.30233
36 3UDZ ADP 0.001802 0.40198 11.2717
37 3PVW QRX 0.005321 0.40281 14.8649
38 5OO5 UUA 0.00778 0.4121 17.7419
Pocket No.: 4; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found: 64
This union binding pocket(no: 4) in the query (biounit: 2q7d.bio4) has 27 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3HZT J60 0.001713 0.45984 1.44509
2 2CFM AMP 0.006845 0.42993 1.44509
3 2VZ6 FEF 0.006732 0.42598 1.59744
4 3IT7 TLA 0.007324 0.42944 1.64835
5 3RFA SAM 0.01119 0.4044 2.02312
6 1UPR 4IP 0.02607 0.40791 2.43902
7 1JPA ANP 0.005537 0.45734 2.5641
8 2WQN ADP 0.01734 0.40597 2.58065
9 2REG CHT 0.02974 0.40741 2.60116
10 2B9I ADP 0.01284 0.40169 2.60116
11 3PLS ANP 0.004345 0.42691 2.68456
12 4BFM ANP 0.008385 0.40352 2.69461
13 3GC0 AMP 0.005462 0.43039 2.73556
14 3UIM ANP 0.002822 0.43159 2.76074
15 1U59 STU 0.00211 0.43732 2.78746
16 4AZT LY2 0.00111 0.46918 2.89017
17 4K38 SAM 0.007621 0.40859 2.89017
18 2PVF ACP 0.007571 0.41572 2.99401
19 3GQI ACP 0.01363 0.4005 3.06748
20 3V8S 0HD 0.001071 0.45511 3.17919
21 2Q09 DI6 0.02642 0.40444 3.17919
22 3TDV GDP 0.003636 0.4266 3.26797
23 2GQS ADP 0.004319 0.42704 3.37553
24 1CKM GTP 0.005233 0.44045 3.46821
25 3VSV XYS 0.03023 0.4112 3.46821
26 1V0O INR 0.0108 0.40184 3.47222
27 4H3P ANP 0.002838 0.43148 3.75723
28 2R5T ANP 0.004928 0.41031 3.75723
29 1ZP9 ATP 0.002028 0.44664 4.26357
30 4IZY 1J2 0.006404 0.40863 4.33526
31 1N5S ADL 0.00876 0.41277 4.46429
32 4JGP PYR 0.001761 0.47239 4.60829
33 2PZI AXX 0.0008637 0.46925 4.69897
34 1TZD ADP 0.00007565 0.5432 4.72727
35 1W2D ADP 0.00125 0.46663 4.90566
36 4HY1 19X 0.02744 0.40359 4.91329
37 1KTG AMP 0.01833 0.4113 5.07246
38 2YAB AMP 0.004331 0.4195 5.20231
39 4NST ADP 0.001889 0.4395 5.22388
40 1BYG STU 0.004392 0.43073 5.39568
41 2BKK ADP 0.001887 0.45279 5.91716
42 4IJ6 SEP 0.03189 0.40638 6.16114
43 4LH7 1X8 0.00002783 0.57542 6.35838
44 2H8H H8H 0.007894 0.4113 6.35838
45 2ZV2 609 0.001462 0.46325 6.37584
46 4M69 ANP 0.00517 0.41268 6.38978
47 1UNH IXM 0.002717 0.44511 6.73077
48 1H2T GDP 7MG 0.01532 0.40146 6.93642
49 1KAE HSO 0.03026 0.4014 6.93642
50 1FAO 4IP 0.004959 0.44671 7.14286
51 2IDO TMP 0.03824 0.40012 7.22892
52 5E58 CPZ 0.0281 0.40313 8.09249
53 3CQ5 PMP 0.03547 0.40175 8.3815
54 4CFU 2WC 0.002372 0.44342 8.58086
55 4BCM T7Z 0.003507 0.45458 8.63787
56 4BCN T9N 0.001615 0.45607 8.66667
57 1K3A ACP 0.003965 0.43715 8.69565
58 4H9T HL4 0.02065 0.40995 9.09091
59 1U5R ATP 0.01181 0.40334 9.24856
60 2YRX AMP 0.0001673 0.52531 10.4046
61 2D6M LBT 0.035 0.40769 10.6918
62 3DGY 2GP 0.006883 0.44085 11.3402
63 3DWB RDF 0.01359 0.41112 17.052
64 1LRH NLA 0.01877 0.41208 20.8589
Pocket No.: 5; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 2q7d.bio4) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 2q7d.bio2) has 27 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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