Receptor
PDB id Resolution Class Description Source Keywords
2PP1 2.2 Å EC: 4.-.-.- CRYSTAL STRUCTURE OF L-TALARATE/GALACTARATE DEHYDRATASE FROM SALMONELLA TYPHIMURIUM LT2 LIGANDED WITH MG AND L-LYXAROHYD SALMONELLA TYPHIMURIUM ENOLASE SUPERFAMILY L-TALARATE/GALACTARATE DEHYDRATASE LYA
Ref.: EVOLUTION OF ENZYMATIC ACTIVITIES IN THE ENOLASE SUPERFAMILY: L-TALARATE/GALACTARATE DEHYDRATASE FRO SALMONELLA TYPHIMURIUM LT2. BIOCHEMISTRY V. 46 9564 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LLH A:801;
B:802;
C:803;
D:804;
E:805;
F:806;
 Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
 none;
none;
none;
none;
none;
none;
 submit data
195.127 C5 H9 N O7 [C@H]...
MG A:399;
B:444;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2PP3 2.2 Å EC: 4.-.-.- CRYSTAL STRUCTURE OF L-TALARATE/GALACTARATE DEHYDRATASE MUTA LIGANDED WITH MG AND L-GLUCARATE SALMONELLA TYPHIMURIUM ENOLASE SUPERFAMILY L-TALARATE/GALACTARATE DEHYDRATASE LYA
Ref.: EVOLUTION OF ENZYMATIC ACTIVITIES IN THE ENOLASE SUPERFAMILY: L-TALARATE/GALACTARATE DEHYDRATASE FRO SALMONELLA TYPHIMURIUM LT2. BIOCHEMISTRY V. 46 9564 2007
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 62 families.
1 2PP1 - LLH C5 H9 N O7 [C@H]([C@H....
2 2PP3 - LGT C6 H10 O8 [C@@H]([C@....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 59 families.
1 2PP1 - LLH C5 H9 N O7 [C@H]([C@H....
2 2PP3 - LGT C6 H10 O8 [C@@H]([C@....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 47 families.
1 2PP1 - LLH C5 H9 N O7 [C@H]([C@H....
2 2PP3 - LGT C6 H10 O8 [C@@H]([C@....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: LLH; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 HDL 1 1
2 LLH 1 1
3 XYH 0.580645 0.970588
Similar Ligands (3D)
Ligand no: 1; Ligand: LLH; Similar ligands found: 325
No: Ligand Similarity coefficient
1 GCO 0.9828
2 TAG 0.9503
3 SOR 0.9428
4 GLR 0.9410
5 DXG 0.9385
6 GAE 0.9326
7 RNS 0.9306
8 AOS 0.9256
9 PSJ 0.9237
10 F4K 0.9235
11 LGT 0.9224
12 SOL 0.9214
13 56D 0.9201
14 3LR 0.9190
15 FUD 0.9188
16 PNZ 0.9187
17 CPZ 0.9185
18 MSR 0.9183
19 TYL 0.9183
20 PPY 0.9143
21 RNT 0.9143
22 FOC 0.9138
23 HFA 0.9135
24 TYR 0.9134
25 HIS 0.9131
26 HNL 0.9130
27 TZF 0.9111
28 CS2 0.9106
29 PHE 0.9092
30 RNO 0.9090
31 AKG 0.9086
32 LPK 0.9085
33 ISA 0.9085
34 SNO 0.9082
35 NFA 0.9076
36 A3M 0.9071
37 REL 0.9067
38 OTR 0.9050
39 6NI 0.9048
40 GLY GLY GLY 0.9045
41 AMH 0.9044
42 9SE 0.9043
43 3YP 0.9038
44 ALA ALA 0.9034
45 4LV 0.9032
46 36Y 0.9032
47 CFA 0.9031
48 A7N 0.9030
49 I3E 0.9005
50 2QC 0.9005
51 5XB 0.9004
52 DZA 0.9003
53 A5E 0.9002
54 HL4 0.9000
55 36E 0.8998
56 HWD 0.8995
57 2FT 0.8995
58 DVQ 0.8987
59 SDD 0.8987
60 GLO 0.8984
61 PH3 0.8983
62 2HG 0.8983
63 12T 0.8980
64 DPN 0.8980
65 HNH 0.8976
66 BHU 0.8975
67 HX4 0.8975
68 0NX 0.8974
69 TYE 0.8972
70 KDG 0.8970
71 DIR 0.8969
72 E5X 0.8967
73 E1P 0.8964
74 DTY 0.8963
75 ICT 0.8963
76 3BU 0.8961
77 M5E 0.8959
78 AFS 0.8955
79 DA3 0.8953
80 BPN 0.8952
81 YI6 0.8950
82 PFF 0.8947
83 HGA 0.8947
84 OGA 0.8945
85 N9J 0.8943
86 AOT 0.8943
87 DAH 0.8940
88 EN1 0.8940
89 FIX 0.8938
90 RAT 0.8932
91 ENO 0.8929
92 MAH 0.8929
93 5UK 0.8926
94 DGN 0.8925
95 HIC 0.8924
96 1L5 0.8924
97 C1M 0.8923
98 41K 0.8922
99 ARG 0.8920
100 KTJ 0.8919
101 SHI 0.8913
102 S0E 0.8912
103 LX1 0.8912
104 1FD 0.8912
105 E0O 0.8908
106 3MF 0.8906
107 DEW 0.8903
108 NF3 0.8902
109 TYC 0.8901
110 LFC 0.8899
111 7O4 0.8898
112 7UC 0.8896
113 R9J 0.8896
114 1Z6 0.8895
115 86L 0.8894
116 4I8 0.8894
117 PO6 0.8890
118 4TB 0.8889
119 4BF 0.8889
120 UA5 0.8888
121 RES 0.8880
122 M4S 0.8876
123 JDN 0.8875
124 E4P 0.8874
125 DHI 0.8874
126 EHM 0.8874
127 54Z 0.8871
128 3PG 0.8869
129 M74 0.8867
130 B3M 0.8867
131 5RP 0.8867
132 3W8 0.8865
133 F4E 0.8864
134 MZT 0.8862
135 DXP 0.8859
136 4LW 0.8855
137 L14 0.8854
138 492 0.8854
139 K82 0.8854
140 8SZ 0.8854
141 HDH 0.8854
142 RQD 0.8853
143 PHI 0.8853
144 3XR 0.8853
145 GLU 0.8852
146 4NM 0.8852
147 FTV 0.8851
148 PFL 0.8851
149 GLN 0.8849
150 657 0.8847
151 PQK 0.8846
152 S2P 0.8846
153 HJH 0.8846
154 AH8 0.8845
155 GF4 0.8844
156 DGL 0.8843
157 XUL 0.8841
158 B40 0.8837
159 SEP 0.8837
160 BRH 0.8836
161 ZZU 0.8835
162 4NB 0.8832
163 SG3 0.8832
164 M6H 0.8827
165 CCB 0.8826
166 9FH 0.8824
167 AES 0.8822
168 RA7 0.8821
169 TX4 0.8820
170 5WZ 0.8819
171 ZEC 0.8819
172 LUQ 0.8818
173 11C 0.8818
174 HNK 0.8817
175 9VQ 0.8817
176 2BX 0.8813
177 Q07 0.8812
178 AHN 0.8812
179 SD4 0.8811
180 FA1 0.8808
181 Q06 0.8808
182 QUS 0.8806
183 JAH 0.8803
184 4JC 0.8800
185 JB8 0.8800
186 HCI 0.8798
187 PDC 0.8798
188 GZQ 0.8798
189 MES 0.8798
190 KBZ 0.8796
191 MTL 0.8796
192 Z13 0.8795
193 ATX 0.8786
194 SSC 0.8784
195 0A9 0.8781
196 OOG 0.8781
197 J9N 0.8779
198 D5X 0.8776
199 Y4L 0.8776
200 XYL 0.8772
201 EOU 0.8772
202 4VY 0.8770
203 46P 0.8765
204 36M 0.8765
205 ONL 0.8763
206 2UB 0.8761
207 PCS 0.8761
208 6JN 0.8760
209 FBF 0.8760
210 IFG 0.8759
211 OSE 0.8755
212 OQC 0.8754
213 Q9Z 0.8752
214 AL0 0.8751
215 AM4 0.8750
216 DER 0.8747
217 ODO 0.8747
218 152 0.8746
219 QDK 0.8745
220 HF2 0.8745
221 80G 0.8745
222 3R4 0.8745
223 449 0.8744
224 XXP 0.8743
225 B3U 0.8742
226 LVD 0.8741
227 GVM 0.8740
228 O45 0.8732
229 XLS 0.8731
230 88L 0.8729
231 LYS 0.8728
232 9ON 0.8728
233 13P 0.8723
234 S7J 0.8723
235 E79 0.8720
236 MEV 0.8715
237 P4F 0.8714
238 3CR 0.8712
239 MZM 0.8711
240 RBL 0.8710
241 AZM 0.8710
242 9GB 0.8704
243 61M 0.8704
244 PGH 0.8704
245 CUW 0.8702
246 UN1 0.8702
247 FOM 0.8699
248 XI7 0.8698
249 TIH 0.8698
250 LY0 0.8695
251 129 0.8694
252 K4V 0.8691
253 LYN 0.8691
254 HBU 0.8690
255 9YT 0.8690
256 DEZ 0.8690
257 4A5 0.8688
258 ZGL 0.8687
259 JQ5 0.8685
260 X1R 0.8683
261 S2G 0.8682
262 3VQ 0.8678
263 2ED 0.8677
264 RB5 0.8676
265 SYM 0.8675
266 IYR 0.8675
267 DJN 0.8672
268 C53 0.8671
269 KMH 0.8670
270 RUJ 0.8666
271 IAR 0.8665
272 STX 0.8663
273 0A1 0.8660
274 4V2 0.8658
275 3VW 0.8656
276 14W 0.8655
277 DYT 0.8655
278 2IT 0.8654
279 TZM 0.8654
280 GGL 0.8651
281 5DS 0.8649
282 G3P 0.8647
283 7BC 0.8646
284 H4E 0.8646
285 1X4 0.8645
286 CXP 0.8645
287 4CM 0.8640
288 GGB 0.8638
289 2D8 0.8638
290 SWX 0.8636
291 YOF 0.8633
292 URQ 0.8628
293 HG3 0.8627
294 8GL 0.8625
295 PUE 0.8625
296 BL0 0.8616
297 ROR 0.8612
298 PA5 0.8609
299 OHJ 0.8608
300 LR5 0.8602
301 ONH 0.8601
302 2FY 0.8597
303 BGT 0.8597
304 NMH 0.8596
305 MSL 0.8595
306 650 0.8593
307 I38 0.8588
308 R5P 0.8584
309 8EW 0.8583
310 AVO 0.8583
311 CCD 0.8582
312 5DL 0.8579
313 A5P 0.8579
314 LXP 0.8572
315 MEQ 0.8570
316 CCU 0.8565
317 IPO 0.8563
318 KPC 0.8561
319 R52 0.8556
320 HHI 0.8555
321 7A3 0.8547
322 TPO 0.8542
323 4NZ 0.8534
324 HLP 0.8528
325 HL5 0.8513
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2pp3.bio2) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2pp3.bio2) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2pp3.bio3) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2pp3.bio3) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 2pp3.bio3) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 2pp3.bio3) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 2pp3.bio3) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 2pp3.bio3) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 2pp3.bio5) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 10; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 10) in the query (biounit: 2pp3.bio5) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 11; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 11) in the query (biounit: 2pp3.bio5) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 12; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 12) in the query (biounit: 2pp3.bio5) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 13; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 13) in the query (biounit: 2pp3.bio5) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 14; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 14) in the query (biounit: 2pp3.bio5) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 15; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 15) in the query (biounit: 2pp3.bio5) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 16; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 16) in the query (biounit: 2pp3.bio5) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 17; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 17) in the query (biounit: 2pp3.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 18; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 18) in the query (biounit: 2pp3.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 19; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 19) in the query (biounit: 2pp3.bio6) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 20; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 20) in the query (biounit: 2pp3.bio6) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 21; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 21) in the query (biounit: 2pp3.bio6) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 22; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 22) in the query (biounit: 2pp3.bio6) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 23; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 23) in the query (biounit: 2pp3.bio6) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 24; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 24) in the query (biounit: 2pp3.bio6) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 25; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 25) in the query (biounit: 2pp3.bio6) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 26; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 26) in the query (biounit: 2pp3.bio6) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 27; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 27) in the query (biounit: 2pp3.bio4) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 28; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 28) in the query (biounit: 2pp3.bio4) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 29; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 29) in the query (biounit: 2pp3.bio4) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 30; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 30) in the query (biounit: 2pp3.bio4) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 31; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 31) in the query (biounit: 2pp3.bio4) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 32; Query (leader) PDB : 2PP3; Ligand: LGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 32) in the query (biounit: 2pp3.bio4) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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