Receptor
PDB id Resolution Class Description Source Keywords
2P7Q 2.4 Å EC: 4.-.-.- CRYSTAL STRUCTURE OF E126Q MUTANT OF GENOMICALLY ENCODED FOS RESISTANCE PROTEIN, FOSX, FROM LISTERIA MONOCYTOGENES COMPLM N(II) AND 1S,2S-DIHYDROXYPROPYLPHOSPHONIC ACID LISTERIA MONOCYTOGENES FOSFOMYCIN RESISTANCE PROTEIN MN BINDING ANTIBIOTIC RESISTMETAL BINDING PROTEIN HYDROLASE
Ref.: STRUCTURE AND MECHANISM OF THE GENOMICALLY ENCODED FOSFOMYCIN RESISTANCE PROTEIN, FOSX, FROM LISTERIA MONOCYTOGENES. BIOCHEMISTRY V. 46 8110 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GG6 A:2002;
B:1002;
C:4002;
D:3002;
E:6002;
F:5002;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
submit data
156.074 C3 H9 O5 P C[C@@...
MN A:2001;
B:1001;
C:4001;
D:3001;
E:6001;
F:5001;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2P7Q 2.4 Å EC: 4.-.-.- CRYSTAL STRUCTURE OF E126Q MUTANT OF GENOMICALLY ENCODED FOS RESISTANCE PROTEIN, FOSX, FROM LISTERIA MONOCYTOGENES COMPLM N(II) AND 1S,2S-DIHYDROXYPROPYLPHOSPHONIC ACID LISTERIA MONOCYTOGENES FOSFOMYCIN RESISTANCE PROTEIN MN BINDING ANTIBIOTIC RESISTMETAL BINDING PROTEIN HYDROLASE
Ref.: STRUCTURE AND MECHANISM OF THE GENOMICALLY ENCODED FOSFOMYCIN RESISTANCE PROTEIN, FOSX, FROM LISTERIA MONOCYTOGENES. BIOCHEMISTRY V. 46 8110 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 38 families.
1 2P7Q - GG6 C3 H9 O5 P C[C@@H]([C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 35 families.
1 2P7Q - GG6 C3 H9 O5 P C[C@@H]([C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 27 families.
1 2P7Q - GG6 C3 H9 O5 P C[C@@H]([C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GG6; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 GG6 1 1
2 TB6 0.409091 0.758621
3 S0H 0.409091 0.758621
4 FFQ 0.409091 0.724138
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: 49
This union binding pocket(no: 1) in the query (biounit: 2p7q.bio1) has 14 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1X0P FAD 0.005564 0.4276 None
2 1SWG BTN 0.01169 0.41743 None
3 3BRN SRO 0.008546 0.41085 None
4 5JSP DQY 0.00903 0.41007 None
5 2BOS GLA GAL GLC 0.004011 0.40438 None
6 2BOS GLA GAL 0.004755 0.40046 None
7 3HX3 RET 0.009472 0.42018 2.25564
8 3O2K DST 0.01167 0.40174 3.00752
9 2R5V HHH 0.000008628 0.50799 3.7594
10 4Q0L V14 0.01882 0.4149 3.7594
11 4MLO PAM 0.01692 0.40339 3.7594
12 3QRC SCR 0.002157 0.44823 4.51128
13 1TFZ 869 0.00008239 0.42409 4.51128
14 4WVW SLT 0.003707 0.42023 4.51128
15 2D6M LBT 0.006953 0.41349 4.51128
16 3K4Z CBI 0.007598 0.40802 4.51128
17 1GP6 QUE 0.03325 0.40324 4.51128
18 1GP6 SIN 0.03133 0.40324 4.51128
19 2OVD DAO 0.01341 0.40171 4.51128
20 2QL9 CIT 0.0007142 0.4717 5.26316
21 4M1U A2G MBG 0.0006612 0.46798 5.26316
22 5F3I 5UJ 0.02988 0.42959 6.01504
23 2Z93 END 0.01204 0.41082 6.01504
24 3AGC RCC 0.0137 0.42497 6.76692
25 3HPY MCT 0.004459 0.42205 6.76692
26 4UIN QI9 0.003493 0.4033 6.76692
27 4S00 AKR 0.01431 0.40032 6.76692
28 5JJ2 MLI 0.001531 0.43989 7.5188
29 1ZM1 BGC BGC BGC 0.002087 0.40254 7.5188
30 4WOE ADP 0.01381 0.40024 7.5188
31 1SQI 869 0.0000236 0.46632 8.27068
32 3U6W KIV 0.001749 0.44454 8.27068
33 1SR9 KIV 0.002454 0.42557 8.27068
34 3ZGJ RMN 0.000003054 0.57532 9.02256
35 2FB3 GTP 0.007268 0.44224 9.02256
36 3AMN CBK 0.002972 0.45509 10.5263
37 3I7V ATP 0.01501 0.40087 10.5263
38 3GFZ FMN 0.004599 0.42939 11.2782
39 3E7O 35F 0.02631 0.41371 12.0301
40 3GM5 CIT 0.0001614 0.49608 12.782
41 1KW6 BPY 0.006569 0.40524 14.2857
42 2IGA XX3 0.0001553 0.43014 15.0376
43 2IGA XX2 0.0005087 0.41803 15.0376
44 2IGA XXP 0.001844 0.41188 15.0376
45 3WV6 GAL BGC 0.007677 0.41651 24.0602
46 2AGC DAO 0.007106 0.40264 25.5639
47 1F1V DHY 0.002333 0.42583 40.6015
48 1NKI PPF 0.000005496 0.56297 45.8647
49 5V3D FCN 0.000003196 0.58655 48.1203
Pocket No.: 2; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2p7q.bio1) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2p7q.bio3) has 14 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: 50
This union binding pocket(no: 4) in the query (biounit: 2p7q.bio3) has 15 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1J3R 6PG 0.0008494 0.45692 None
2 3GZ8 APR 0.01471 0.41138 None
3 3ZXE PGZ 0.002183 0.4096 None
4 5HZ9 5M8 0.0009141 0.40845 None
5 2VFT SOR 0.006333 0.40611 None
6 2ZI8 SDT 0.01025 0.40254 None
7 2ET1 GLV 0.01453 0.40184 None
8 2ZHL NAG GAL GAL NAG 0.005386 0.40131 None
9 1N5S ADL 0.002261 0.40091 None
10 3RGA LSB 0.001183 0.41443 1.50376
11 4YLZ LAT NAG GAL 0.0008173 0.46409 2.25564
12 4H6B 10X 0.004692 0.40404 2.25564
13 3OUM TOF 0.008671 0.40863 2.58621
14 4QCK ASD 0.001998 0.41034 3.7594
15 5T7I LAT NAG GAL 0.003043 0.4344 4.51128
16 5H9P TD2 0.004407 0.42514 4.51128
17 4BVA T3 0.02003 0.4244 4.51128
18 4FFG 0U8 0.004631 0.42409 4.51128
19 3E8T UQ8 0.03396 0.42316 4.51128
20 1Y0G 8PP 0.02557 0.42145 4.51128
21 3OYW TDG 0.006041 0.41844 4.51128
22 2WA4 069 0.001191 0.42884 5.26316
23 4P7X AKG 0.01374 0.40751 5.26316
24 2XOM GAL GAL GAL 0.004413 0.43684 6.01504
25 1ULE GLA GAL NAG 0.003773 0.42403 6.01504
26 1M15 ARG 0.02831 0.41132 6.01504
27 1M15 ADP 0.02831 0.41132 6.01504
28 5ISY NAD 0.005364 0.40144 6.01504
29 3MTX PGT 0.01351 0.43046 6.76692
30 5DG2 GAL GLC 0.006136 0.4212 6.76692
31 1OFZ FUC 0.005412 0.42254 7.5188
32 3PUR 2HG 0.01191 0.4057 7.5188
33 4QDF 30Q 0.002188 0.40222 7.5188
34 4Y24 TD2 0.006749 0.40303 8.27068
35 2HZQ STR 0.00009751 0.51034 9.02256
36 3SAO NKN 0.002889 0.42037 9.02256
37 1REQ DCA 0.03796 0.41298 9.02256
38 2GC0 PAN 0.0007901 0.4078 9.02256
39 5L6G XYP 0.01383 0.40279 9.02256
40 4CNO 9PY 0.01554 0.40052 9.02256
41 1Y7P RIP 0.01774 0.40017 9.02256
42 4QXB OGA 0.003257 0.42625 9.77444
43 4QYN RTL 0.0176 0.40906 9.77444
44 2WL9 MBD 0.01226 0.40524 9.77444
45 4ZSI GLP 0.002367 0.40199 9.77444
46 5EOB 5QQ 0.007409 0.45815 12.0301
47 5KEW 6SB 0.003007 0.4279 12.0301
48 3HQP OXL 0.01555 0.40397 12.0301
49 5OO5 UUA 0.0007091 0.42221 19.3548
50 1P0Z FLC 0.009489 0.41122 19.8473
Pocket No.: 5; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 2p7q.bio2) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: 4
This union binding pocket(no: 6) in the query (biounit: 2p7q.bio2) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4H6B 10Y 0.002078 0.41179 2.25564
2 4OSP 2V4 0.004653 0.41225 3.7594
3 4LIT AKG 0.005482 0.41699 9.77444
4 3Q8G PEE 0.009728 0.45866 14.2857
Pocket No.: 7; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 2p7q.bio4) has 14 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 2p7q.bio4) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 2p7q.bio4) has 14 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 10; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: 1
This union binding pocket(no: 10) in the query (biounit: 2p7q.bio4) has 15 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3WG3 A2G GAL NAG FUC 0.003531 0.43171 15.0376
Pocket No.: 11; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 11) in the query (biounit: 2p7q.bio4) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 12; Query (leader) PDB : 2P7Q; Ligand: GG6; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 12) in the query (biounit: 2p7q.bio4) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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