Receptor
PDB id Resolution Class Description Source Keywords
2OVR 2.5 Å EC: 2.-.-.- STRUCTURE OF THE SKP1-FBW7-CYCLINEDEGN COMPLEX HOMO SAPIENS F-BOX; WD40 DOMAINS; DOUBLE PHOSPHORYLATION TRANSCRIPTION-CCOMPLEX
Ref.: STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX: MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY S UBIQUITIN LIGASES MOL.CELL V. 26 131 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER LEU ILE PRO TPO PRO ASP LYS C:58;
Valid;
none;
submit data
947.978 n/a [P+](...
SO4 B:901;
B:902;
B:903;
B:904;
B:905;
B:906;
B:907;
B:908;
B:909;
B:910;
B:911;
B:912;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2OVR 2.5 Å EC: 2.-.-.- STRUCTURE OF THE SKP1-FBW7-CYCLINEDEGN COMPLEX HOMO SAPIENS F-BOX; WD40 DOMAINS; DOUBLE PHOSPHORYLATION TRANSCRIPTION-CCOMPLEX
Ref.: STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX: MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY S UBIQUITIN LIGASES MOL.CELL V. 26 131 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 236 families.
1 2OVR - SER LEU ILE PRO TPO PRO ASP LYS n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 211 families.
1 2OVR - SER LEU ILE PRO TPO PRO ASP LYS n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 166 families.
1 2OVR - SER LEU ILE PRO TPO PRO ASP LYS n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SER LEU ILE PRO TPO PRO ASP LYS; Similar ligands found: 47
No: Ligand ECFP6 Tc MDL keys Tc
1 SER LEU ILE PRO TPO PRO ASP LYS 1 1
2 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.506098 0.905405
3 ALA GLY SER VAL GLU GLN TPO PRO LYS LYS 0.5 0.928571
4 LEU LEU CYS SER TPO PRO ASN GLY LEU 0.496504 0.901408
5 SER SER GLY LYS VAL PRO LEU 0.481203 0.838235
6 GLY SER ASP PRO PHE LYS 0.477941 0.771429
7 SER SER GLY LYS VAL PRO LEU SER 0.474453 0.852941
8 SER ASP ILE LEU PHE PRO ALA ASP SER 0.469388 0.828571
9 GLU LEU PRO LEU VAL LYS ILE 0.467626 0.764706
10 LYS LEU THR PRO LEU CYS VAL THR LEU 0.464789 0.826087
11 LEU PRO PHE ASP LYS THR THR ILE MET 0.447205 0.783784
12 LEU PRO PHE ASP LYS SER THR ILE MET 0.445783 0.810811
13 ASN ARG PRO ILE LEU SER LEU 0.445205 0.786667
14 GLU PTR LEU GLY LEU ASP VAL PRO VAL 0.444444 0.75
15 GLY SER ASP PRO TRP LYS 0.442177 0.753425
16 TRP MET ASP PHE ASP ASP ASP ILE PRO PHE 0.439394 0.714286
17 TRP ASP ILE PRO PHE 0.439394 0.714286
18 MET GLN SER TPO PRO LEU 0.436242 0.876712
19 HIS ALA TPO PRO PRO LYS LYS GLU ALA ASP 0.434524 0.847222
20 SER VAL PRO ILE 0.434426 0.794118
21 SER PRO LYS ARG ILE ALA 0.433566 0.756757
22 SER ALA PRO ASP THR ARG PRO ALA 0.432432 0.786667
23 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.431373 0.77027
24 PHE PRO THR LYS ASP VAL ALA LEU 0.423077 0.814286
25 SER PRO HIS ASN PRO ILE SER ASP VAL ASP 0.42029 0.842857
26 SER ALA GLU PRO VAL PRO LEU GLN LEU 0.418919 0.855072
27 SER PRO LEU ASP SER LEU TRP TRP ILE 0.41875 0.810811
28 CYS THR PRO SER ARG 0.417266 0.733333
29 ACE MET GLN SER TPO PRO LEU NH2 0.417219 0.864865
30 ASN LEU VAL PRO SER VAL ALA THR VAL 0.414966 0.828571
31 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.414013 0.805556
32 SER SER CYS PRO LEU SER LYS 0.410072 0.811594
33 SER LEU LYS ILE ASP ASN LEU ASP 0.410072 0.671429
34 GLU LYS PRO SER SER SER 0.409091 0.794118
35 SER ARG ASP HIS SER ARG THR PRO MET 0.408284 0.740741
36 TYR LEU GLY GLY PRO ASP PHE PRO THR ILE 0.406977 0.810811
37 ASN LEU VAL PRO THR VAL ALA THR VAL 0.406897 0.8
38 GLU ARG THR ILE PRO ILE THR ARG GLU 0.406667 0.797297
39 SER LEU LYS ILE ASP ASN MET ASP 0.40411 0.635135
40 ASN LEU VAL PRO VAL VAL ALA THR VAL 0.40411 0.8
41 THR PRO GLN ASP LEU ASN THR MET LEU 0.403846 0.77027
42 SER SER CYS SER SER CYS PRO LEU SER LYS 0.403727 0.797297
43 SER ASP LYS ILE ASP ASN LEU ASP 0.402878 0.671429
44 SER LEU LYS ILE ASP ASN GLU ASP 0.402778 0.671429
45 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.401316 0.797297
46 LYS PRO LYS 0.4 0.647059
47 PTR VAL PRO MET LEU 0.4 0.776316
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2OVR; Ligand: SER LEU ILE PRO TPO PRO ASP LYS; Similar sites found: 6
This union binding pocket(no: 1) in the query (biounit: 2ovr.bio1) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5K8B PDG 0.01843 0.41392 6.71141
2 4Z5W TYS ILE TYS THR GLN 0.03311 0.40119 11.4094
3 5TEF GTG 0.001474 0.44919 14.094
4 5MWJ EBU 0.00157 0.45595 25.816
5 5U6D 7XG 0.003402 0.44971 27.3713
6 5WUK 73K 0.0007916 0.46689 27.8689
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