Receptor
PDB id Resolution Class Description Source Keywords
2O9V 1.63 Å NON-ENZYME: BINDING THE SECOND SH3 DOMAIN FROM PONSIN IN COMPLEX WITH THE PAXILL RICH REGION HOMO SAPIENS SH3 DOMAIN PONSIN PAXILLIN PROLINE-RICH-REGION SIGNALINGCELL ADHESION COMPLEX
Ref.: PAXILLIN AND PONSIN INTERACT IN NASCENT COSTAMERES CELLS J.MOL.BIOL. V. 369 665 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
VAL PRO PRO PRO VAL PRO PRO PRO PRO SER B:45;
Valid;
none;
Kd = 288 uM
968.187 n/a O=C(C...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2O9V 1.63 Å NON-ENZYME: BINDING THE SECOND SH3 DOMAIN FROM PONSIN IN COMPLEX WITH THE PAXILL RICH REGION HOMO SAPIENS SH3 DOMAIN PONSIN PAXILLIN PROLINE-RICH-REGION SIGNALINGCELL ADHESION COMPLEX
Ref.: PAXILLIN AND PONSIN INTERACT IN NASCENT COSTAMERES CELLS J.MOL.BIOL. V. 369 665 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
50% Homology Family (13)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
2 2J6O Kd ~ 100 uM LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL n/a n/a
3 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
4 1FYN - PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO n/a n/a
5 1ABO - ALA PRO THR MET PRO PRO PRO LEU PRO PRO n/a n/a
6 4LNP Kd = 214 uM VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU n/a n/a
7 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
8 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
9 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
10 2SEM - ACE PRO PRO PRO VAL IPG PRO ARG ARG n/a n/a
11 3SEM - PRO PRO PRO VAL NMC PRO ARG ARG ARG n/a n/a
12 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
13 4HXJ Kd = 74.3 uM ARG GLY THR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: VAL PRO PRO PRO VAL PRO PRO PRO PRO SER; Similar ligands found: 20
No: Ligand ECFP6 Tc MDL keys Tc
1 VAL PRO PRO PRO VAL PRO PRO PRO PRO SER 1 1
2 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.59375 0.793651
3 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.526316 0.890909
4 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 0.478261 0.892857
5 PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO 0.46087 0.83871
6 SER PRO SER PRO SER PRO SER PRO SER PRO 0.456522 0.928571
7 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.455357 0.836066
8 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.454545 0.765625
9 01B PRO PRO ALA NH2 0.44898 0.819672
10 ACE PRO PRO PRO VAL IPG PRO ARG ARG 0.424779 0.78125
11 SER VAL PRO ILE 0.421053 0.866667
12 THR PRO PRO SER PRO PHE 0.420561 0.883333
13 ALA VAL PRO ILE ALA GLN LYS SER GLU 0.419355 0.807018
14 ALA VAL PRO ILE ALA GLN LYS 0.419355 0.807018
15 PRO PRO PRO PRO PRO PRO LEU PRO PRO 0.419048 0.892857
16 ACE GLU VAL ASN PRO PRO VAL PRO NH2 0.418803 0.836066
17 MET PRO PRO PRO PRO SEP PRO CYS THR 0.418182 0.796875
18 ALA PRO THR MET PRO PRO PRO LEU PRO PRO 0.412281 0.815385
19 MET PRO PRO PRO PRO TPO PRO ARG SER 0.4 0.78125
20 ALA VAL PRO ALA 0.4 0.821429
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2O9V; Ligand: VAL PRO PRO PRO VAL PRO PRO PRO PRO SER; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2o9v.bio1) has 2 residues
No: Leader PDB Ligand Sequence Similarity
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