Receptor
PDB id Resolution Class Description Source Keywords
2O9V 1.63 Å NON-ENZYME: BINDING THE SECOND SH3 DOMAIN FROM PONSIN IN COMPLEX WITH THE PAXILLIN PROLINE RICH REGION HOMO SAPIENS SH3 DOMAIN PONSIN PAXILLIN PROLINE-RICH-REGION SIGNALING PROTEIN/CELL ADHESION COMPLEX
Ref.: PAXILLIN AND PONSIN INTERACT IN NASCENT COSTAMERES OF MUSCLE CELLS J.MOL.BIOL. V. 369 665 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
VAL PRO PRO PRO VAL PRO PRO PRO PRO SER B:45;
Valid;
none;
Kd = 288 uM
968.187 n/a O=C(N...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2O9V 1.63 Å NON-ENZYME: BINDING THE SECOND SH3 DOMAIN FROM PONSIN IN COMPLEX WITH THE PAXILLIN PROLINE RICH REGION HOMO SAPIENS SH3 DOMAIN PONSIN PAXILLIN PROLINE-RICH-REGION SIGNALING PROTEIN/CELL ADHESION COMPLEX
Ref.: PAXILLIN AND PONSIN INTERACT IN NASCENT COSTAMERES OF MUSCLE CELLS J.MOL.BIOL. V. 369 665 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 473 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 355 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
50% Homology Family (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
2 2J6O Kd ~ 100 uM LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL n/a n/a
3 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
4 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
5 1FYN - PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO n/a n/a
6 1ABO - ALA PRO THR MET PRO PRO PRO LEU PRO PRO n/a n/a
7 4LNP Kd = 214 uM VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU n/a n/a
8 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
9 2D0N - PRO SER ILE ASP ARG SER THR LYS PRO n/a n/a
10 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
11 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
12 3THK - PRO PRO PRO VAL PRO PRO TYR SER ALA GLY n/a n/a
13 2SEM - ACE PRO PRO PRO VAL IPG PRO ARG ARG n/a n/a
14 3SEM - PRO PRO PRO VAL NMC PRO ARG ARG ARG n/a n/a
15 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
16 4HXJ Kd = 74.3 uM ARG GLY THR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: VAL PRO PRO PRO VAL PRO PRO PRO PRO SER; Similar ligands found: 13
No: Ligand ECFP6 Tc MDL keys Tc
1 VAL PRO PRO PRO VAL PRO PRO PRO PRO SER 1 1
2 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.522523 0.777778
3 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.50505 0.833333
4 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.454545 0.75
5 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.451327 0.819672
6 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 0.447917 0.854545
7 PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO 0.436975 0.836066
8 THR PRO PRO SER PRO PHE 0.423423 0.881356
9 01B PRO PRO ALA NH2 0.413462 0.783333
10 ALA VAL PRO ILE ALA GLN LYS 0.410526 0.785714
11 SER PRO SER PRO SER PRO SER PRO SER PRO 0.408163 0.927273
12 SER VAL PRO ILE 0.408163 0.830508
13 ACE GLU VAL ASN PRO PRO VAL PRO NH2 0.403361 0.819672
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2O9V; Ligand: VAL PRO PRO PRO VAL PRO PRO PRO PRO SER; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2o9v.bio1) has 2 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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