Receptor
PDB id Resolution Class Description Source Keywords
2JD5 2.5 Å EC: 2.7.11.1 SKY1P BOUND TO NPL3P-DERIVED SUBSTRATE PEPTIDE SACCHAROMYCES CEREVISIAE MRNA EXPORT PROTEIN SERINE/THREONINE-PROTEIN KINASE KINASETRANSFERASE ATP-BINDING NUCLEOTIDE-BINDING
Ref.: THE RGG DOMAIN OF NPL3P RECRUITS SKY1P THROUGH DOCK INTERACTIONS J.MOL.BIOL. V. 367 249 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ARG GLU ARG SER PRO THR ARG C:654;
Valid;
none;
submit data
543.602 n/a O=C([...
MG A:1739;
B:1739;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
SO4 A:1740;
B:1738;
Invalid;
Invalid;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1Q8Y 2.05 Å EC: 2.7.11.1 THE STRUCTURE OF THE YEAST SR PROTEIN KINASE, SKY1P, WITH BO SACCHAROMYCES CEREVISIAE PROTEIN KINASE TRANSFERASE
Ref.: NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGES IN THE SACCHAROMYCES CEREVISIAE SR PROTEIN KINASE, SKY1P, BY X-RAY CRYSTALLOGRAPHY BIOCHEMISTRY V. 42 9575 2003
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 107 families.
1 1Q99 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 2JD5 - ARG GLU ARG SER PRO THR ARG n/a n/a
3 1Q8Y - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
4 1Q97 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 82 families.
1 1Q99 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 2JD5 - ARG GLU ARG SER PRO THR ARG n/a n/a
3 1Q8Y - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
4 1Q97 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
50% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 12 families.
1 5MXX ic50 = 31 nM W4A C18 H20 F3 N3 O2 Cc1ccc(o1)....
2 1WBP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
3 5MY8 ic50 = 6 nM RXZ C27 H24 F3 N5 O2 c1ccnc(c1)....
4 4WUA - 3UL C18 H18 F3 N3 O c1cc(c(cc1....
5 1Q99 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
6 2JD5 - ARG GLU ARG SER PRO THR ARG n/a n/a
7 1Q8Y - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
8 1Q97 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ARG GLU ARG SER PRO THR ARG; Similar ligands found: 68
No: Ligand ECFP6 Tc MDL keys Tc
1 ARG GLU ARG SER PRO THR ARG 1 1
2 ARG ARG ARG GLU ARG SER PRO THR ARG 0.538462 0.952381
3 ASP LEU THR ARG PRO 0.5 0.878788
4 GLU ARG THR ILE PRO ILE THR ARG GLU 0.491667 0.893939
5 ILE LYS ARG SER LYS LYS ASN SER LEU ALA 0.489362 0.754098
6 ALA PRO ASP THR ARG PRO 0.486957 0.893939
7 GLY PRO ARG PRO 0.479592 0.83871
8 ALA ARG M3L SER 0.469388 0.685714
9 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.466667 0.907692
10 LYS ALA ALA ARG ALY SER ALA PRO ALA 0.464646 0.71875
11 DMG PRO ARG ARG ARG SER ARG LYS PRO 0.464286 0.880597
12 SER SER ARG LYS GLU TYR TYR ALA 0.463636 0.666667
13 ARG PRO GLY ASN PHE PHE GLN SER ARG PRO 0.460432 0.855072
14 ILE LYS ARG SER MLZ LYS ASN SER LEU ALA 0.455446 0.686567
15 ALA ARG MLZ SER ALA PRO ALA THR 0.45082 0.880597
16 ALA PRO ASP THR ARG PRO ALA PRO 0.45 0.893939
17 ARG ARG ALA SEP ALA PRO LEU PRO 0.449612 0.791667
18 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 0.448 0.757143
19 ARG PRO GLY ASN PHE LEU GLN SER SER PRO 0.445205 0.855072
20 ACE GLN GLU ARG GLU VAL PRO CYS 0.443548 0.875
21 ALA PRO PRO PRO ARG PRO PRO LYS PRO 0.443478 0.825397
22 ALA ARG THR GLU LEU TYR ARG SER LEU 0.44 0.676056
23 LEU PRO PRO GLU GLU ARG LEU ILE 0.435484 0.861538
24 GLY HIS ARG PRO NH2 0.433628 0.828125
25 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.432432 0.842857
26 PRO ALA ILE ILE ASN ARG PRO GLN ASN 0.430894 0.833333
27 ILE GLN GLN SER ILE GLU ARG ILE 0.429825 0.734375
28 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.429688 0.893939
29 PRO GLN ILE ILE ASN ARG PRO GLN ASN 0.428571 0.833333
30 ALA ARG ALA ALA ALA ALA ALA ALA ALA 0.423913 0.672131
31 ALA ILE ARG SER 0.42 0.68254
32 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.419847 0.863636
33 ALA ARG THR ALY GLN THR ALA 0.419643 0.69697
34 ALA ARG THR MLY GLN THR ALA ARG LYS SER 0.419048 0.6875
35 SER PRO LYS ARG ILE ALA 0.418033 0.936508
36 THR PRO ARG ARG SER MLZ SER ALA 0.418033 0.84058
37 ALA ARG SER HIS SEP TYR PRO ALA 0.417808 0.74359
38 ALA ALA ARG KCR SER ALA PRO ALA 0.416667 0.921875
39 ALA ARG THR M3L GLN THR ALA 0.415929 0.680556
40 ALA ARG THR M3L GLN THR ALA ARG LYS SER 0.415929 0.680556
41 ALA ARG THR MLY GLN THR ALA ARG LYS TYR 0.415929 0.7
42 ALA ARG THR M3L GLN THR ALA 2MR LYS 0.415929 0.680556
43 ALA ARG THR MLY GLN THR ALA 0.415929 0.7
44 THR ARG ARG GLU THR GLN LEU 0.414414 0.69697
45 ALA PRO ASP SER ARG PRO A2G 0.414286 0.821918
46 ASP ALA GLU PHE ARG HIS ASP 0.413223 0.742424
47 ALA ARG THR MLZ GLN THR ALA ARG LYS TYR 0.412281 0.676471
48 ALA ARG THR M3L GLN THR ALA ARG LYS 0.412281 0.680556
49 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.411765 0.794521
50 ALA PRO ASP CYS ARG PRO A2G 0.411348 0.8
51 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.411348 0.909091
52 ALA ARG THR 4WQ GLN THR ALA ARG LYS SER 0.411215 0.652174
53 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.410448 0.867647
54 LYS ARG ARG LYS SEP VAL 0.409524 0.681159
55 ALA ARG THR LYS GLN THR ALA ARG LYS SER 0.408696 0.71875
56 ALA ASN SER ARG ALY PRO THR SER ILE ILE 0.408451 0.869565
57 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.406015 0.863636
58 ALA ARG THR LYS GLN THR ALA ARG 0.405172 0.71875
59 ALA ARG THR LYS GLN THR ALA ARG LYS 0.405172 0.71875
60 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.405172 0.69697
61 5JP PRO LYS ARG ILE ALA 0.404762 0.907692
62 ALA ARG 0.404762 0.65
63 VAL LEU ARG ASP ASP LEU LEU GLU ALA 0.40367 0.661538
64 ALA PRO ASP THR ARG PRO A2G 0.402778 0.821918
65 MET ASP PRO VAL ASP PRO ASN ILE GLU 0.402062 0.707692
66 VAL ALA ARG SER 0.402062 0.709677
67 ALA ARG THR MLY GLN 0.4 0.724638
68 ASP THR TYR ALA ALA THR PRO ARG 0.4 0.725806
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1Q8Y; Ligand: ADP; Similar sites found: 308
This union binding pocket(no: 1) in the query (biounit: 1q8y.bio1) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2IO8 ADP 0.0002998 0.43788 1.07239
2 2YW2 ATP 0.003406 0.41199 1.07239
3 3WXL ADP 0.01652 0.41791 1.34048
4 3X01 AMP 0.0003366 0.50244 1.60858
5 3K5I ADP 0.005587 0.40288 1.60858
6 1HSR BHO 0.009498 0.42879 1.74419
7 5T96 79J 0.01919 0.41332 1.75439
8 3WVR AMP 0.00007042 0.4601 1.87668
9 5DZT AMP 0.007252 0.43133 1.87668
10 2PUL ACP 0.00001134 0.53507 2.14477
11 2VPQ ANP 0.0009676 0.43904 2.14477
12 3S6X SIA GAL BGC 0.02163 0.41339 2.15385
13 4LH7 1X8 0.009182 0.42603 2.16718
14 4ZS4 ATP 0.000001088 0.56654 2.28013
15 4GYI ADP 0.000003426 0.57349 2.41287
16 4OCV ANP 0.00000448 0.54 2.41287
17 5C1P ADP 0.001885 0.44393 2.41287
18 2VQD AP2 0.0007421 0.44 2.41287
19 3ZJX BOG 0.005272 0.43943 2.42215
20 3PDT ADP 0.000004739 0.55929 2.54545
21 4P25 FUC GAL NAG FUC 0.01588 0.40801 2.64901
22 5W2I I3P 0.0005404 0.42595 2.72374
23 5W2I ADP 0.0005404 0.42595 2.72374
24 3FIU AMP 0.01486 0.40531 2.81124
25 4UWH JXM 0.008398 0.40924 2.82862
26 5KJW 53C 0.01988 0.41444 2.94906
27 3DNT ATP 0.002785 0.42112 3.21716
28 3TY5 ATP 0.009713 0.41431 3.21716
29 1D4D SIN 0.02309 0.40403 3.21716
30 5K2M ADP 0.0002331 0.46748 3.2967
31 2F9W PAU 0.02187 0.40104 3.32103
32 3HAV ATP 0.005501 0.4115 3.34448
33 2AQX ATP 0.0003303 0.44774 3.46021
34 4OYA 1VE 0.004343 0.44895 3.48525
35 1PK8 ATP 0.000248 0.43441 3.48525
36 4FE2 ADP 0.001227 0.45275 3.52941
37 4FE2 AIR 0.008069 0.41823 3.52941
38 2PYW ADP 0.00002769 0.50039 3.75335
39 4XMF HSM 0.000162 0.51667 3.80435
40 5JBX MLI 0.009429 0.42404 3.83142
41 1KR3 113 0.01743 0.41033 3.87931
42 3KYF 5GP 5GP 0.01524 0.40477 3.8961
43 5IQD GNP 0.0003642 0.47646 3.93443
44 5IQD RIO 0.0003891 0.47646 3.93443
45 4O4F ATP 0.0007747 0.41446 4.03226
46 4O4F IHP 0.0008487 0.40829 4.03226
47 3T2W BTN 0.009808 0.4141 4.09836
48 4YRD 3IT 0.02436 0.40209 4.17827
49 1AUX AGS 0.000424 0.45926 4.18006
50 1I7L ATP 0.0003243 0.43619 4.20712
51 2GQR ADP 0.0007177 0.42583 4.21941
52 5EXK 5AD 0.02242 0.40681 4.22961
53 4CS9 AMP 0.006258 0.44025 4.2328
54 1IOW PHY 0.001933 0.44127 4.24837
55 1ZTH ADP 0.000001589 0.59782 4.26357
56 1ZP9 ATP 0.000003945 0.56297 4.26357
57 4WA2 SIA GAL NAG 0.01957 0.40774 4.28954
58 4M26 AKG 0.01904 0.41002 4.3956
59 2IF8 ADP 0.00005722 0.53726 4.40771
60 3ETH ATP 0.002899 0.41684 4.50704
61 3I0O ADP 0.00007484 0.51678 4.71976
62 3UDZ ADP 0.0000008866 0.55673 4.82574
63 4AXD ANP 0.000001659 0.44744 4.82574
64 4OCJ NDG 0.000003393 0.43865 4.82574
65 1CKN GTP 0.006191 0.42845 4.84848
66 1CKM GTP 0.01078 0.41643 4.84848
67 1W2D ADP 0.0006689 0.4707 4.90566
68 1GSA ADP 0.000024 0.50774 5.06329
69 4O1P ANP 0.00000001053 0.62528 5.09383
70 5VZ0 ADP 0.0005873 0.45771 5.09383
71 5TDF ADP 0.001129 0.43229 5.09383
72 1OBD ATP 0.0006095 0.46712 5.22876
73 1E4E ADP 0.003703 0.41399 5.24781
74 5IGI GMP 0.01728 0.40067 5.31561
75 5IGI ZIT 0.0182 0.40067 5.31561
76 4U98 ACP 0.00122 0.44337 5.36193
77 4AZT LY2 0.002827 0.44035 5.36193
78 4AZW ATP 0.000791 0.43882 5.36193
79 4A4Z ANP 0.01082 0.41202 5.36193
80 1M0W ANP 0.001808 0.40609 5.36193
81 5GZ9 ANP 0.0000000006584 0.7029 5.57377
82 4GLW 0XT 0.0135 0.41155 5.57377
83 4WW7 AMP 0.0001136 0.4767 5.88235
84 4CNG SAH 0.008137 0.40554 5.88235
85 4CYI ATP 0.000064 0.485 5.89812
86 3VOT ADP 0.0006802 0.41283 5.89812
87 3ORQ ADP 0.004133 0.40843 5.89812
88 1F52 ADP 0.01277 0.40454 5.89812
89 2BKK ADP 0.0003917 0.42782 6.06061
90 3E0M SER HIS MET ALA GLU ILE 0.02138 0.40153 6.07029
91 2ZL7 FUC GAL NGA 0.02238 0.40663 6.1017
92 1EHI ADP 0.003588 0.41458 6.16622
93 3P3G UKW 0.01003 0.40293 6.33333
94 3P3G 3P3 0.01003 0.40293 6.33333
95 3VPD ANP 0.001376 0.43062 6.40569
96 5MW8 ATP 0.0000002417 0.59317 6.70241
97 2CFM AMP 0.0068 0.42184 6.70241
98 2XG5 EC2 0.006126 0.43317 6.93642
99 2XG5 EC5 0.006126 0.43317 6.93642
100 3LQV ADE 0.006587 0.44645 6.95652
101 1TQP ATP 0.000002161 0.51893 7.0922
102 5L2J 6UL 0.01414 0.42484 7.14286
103 3TDV GDP 0.00000007808 0.62406 7.18954
104 4R78 AMP 0.00008839 0.52021 7.76699
105 5JSP DQY 0.008766 0.42563 7.9602
106 3W0O ADP 0.0004941 0.40251 8.02292
107 3W0O HY0 0.0004941 0.40251 8.02292
108 4PU5 ANP 0.002065 0.41112 8.0429
109 4XYM A12 0.0004582 0.45321 8.26087
110 2OG2 MLI 0.01062 0.43255 8.35655
111 4IX4 ADP 0.000005477 0.53015 8.57143
112 3H9R TAK 0.00001492 0.5586 8.78788
113 5XQL C2E 0.01517 0.41532 8.93471
114 4DFU QUE 0.01283 0.41717 9.00621
115 5C4L 4XR 0.00004817 0.50825 9.34579
116 5C4L SIS 0.00006784 0.50166 9.34579
117 5I35 ANP 0.00001065 0.53628 9.38338
118 2HGS ADP 0.0005727 0.44879 9.38338
119 1VJY 460 0.000000062 0.51445 9.90099
120 3B9Q MLI 0.01663 0.42428 9.93377
121 5VC5 96M 0.000002753 0.49173 10.0346
122 1YRO UDP 0.01002 0.43291 10.1399
123 5KO1 6UY 0.0000002725 0.60811 10.2473
124 3UN3 G16 0.01261 0.4398 10.4558
125 4RDL FUC GAL NDG FUC 0.01491 0.41672 11.6883
126 1IA9 ANP 0.00000427 0.5409 11.7857
127 1RZ1 NAD 0.0121 0.42144 11.8012
128 5TV6 PML 0.02441 0.40279 12.0833
129 2GQS ADP 0.000306 0.44215 12.2363
130 2H92 C5P 0.01452 0.40188 12.3288
131 3C1X CKK 0.0002455 0.45306 12.3324
132 3HRD MCN 0.009651 0.41105 12.5
133 2CI5 HCS 0.02627 0.403 13.0282
134 4Q5H ANP 0.000004971 0.54447 13.2184
135 5LPZ ADP 0.0000000104 0.66271 13.253
136 3VHE 42Q 0.000001992 0.47693 13.649
137 4U0I 0LI 0.000173 0.48367 13.6508
138 4OAV ACP 0.00000003552 0.64804 13.6729
139 5MRH Q9Z 0.0005935 0.47911 13.6729
140 5NKB 8ZT 0.00001617 0.40561 13.7255
141 3UIM ANP 0.0000001402 0.61285 13.8037
142 4ASE AV9 0.00004597 0.50378 13.881
143 5USZ SKE 0.000002376 0.49848 13.941
144 4IDT T28 0.000000006825 0.68036 14.0449
145 4WNK 453 0.0000000008415 0.59109 14.2091
146 5EOB 5QQ 0.00000008445 0.66428 14.4201
147 4BKJ STI 0.001928 0.40048 14.6032
148 2X2M X2M 0.0000002413 0.57514 14.6497
149 5LPB ADP 0.00000001163 0.70126 14.8649
150 3H0L ADP 0.012 0.41411 14.8936
151 4FL3 ANP 0.00000000129 0.66854 15.1181
152 5T8O 76Z 0.0000000728 0.60948 15.1862
153 3NOJ PYR 0.00775 0.42915 15.5462
154 5CKW ANP 0.00002291 0.54169 15.5496
155 3ALN ANP 0.0000000183 0.63484 16.208
156 5CEO 50D 0.000003696 0.52361 16.6667
157 4WOV 3SM 0.0003112 0.48093 17.3502
158 5JGA 6KC 0.0000005748 0.48159 17.4603
159 1ZY5 ANP 0.0003927 0.4656 17.4917
160 2QLU ADE 0.0000004482 0.66086 17.5159
161 3KMW ATP 0.00002144 0.52257 17.7122
162 4XH0 ADP 0.00000722 0.58826 17.9625
163 4AG8 AXI 0.00001986 0.42187 18.9873
164 5UKL SIX 0.00000002088 0.64976 19.3029
165 3PVW QRX 0.0000001034 0.55121 19.3029
166 2XVD AS6 0.000004172 0.55135 20.5298
167 5DBX ANP 0.00000001037 0.59164 21.0366
168 3VPB ADP 0.00001572 0.47958 21.2766
169 3VPC ADP 0.0001831 0.45858 21.2766
170 4L9I 8PR 0.00000004603 0.64296 22.5201
171 5C03 AGS 0.000009985 0.5311 22.807
172 5MJA 7O3 0.0000092 0.54599 22.9508
173 1OPK P16 0.00007147 0.42334 23.5925
174 4YZC STU 0.000000007534 0.68781 23.8606
175 3PP0 03Q 0.0000003364 0.52916 23.8606
176 4WB7 ATP 0.000000007101 0.5181 24.6649
177 3VRY B43 0.00003132 0.46456 24.6649
178 3SLS ANP 0.00000003185 0.6123 25
179 2H8H H8H 0.00000161 0.53737 25.2011
180 1Y57 MPZ 0.000003332 0.52 25.2011
181 4KBA 1QM 0.00004347 0.44825 25.3776
182 4CLI 5P8 0.000002821 0.5809 25.7373
183 2Y6O 1N1 0.000098 0.46926 25.7732
184 2F57 23D 0.000005031 0.55809 26.183
185 3KRL KRL 0.0000254 0.4934 26.2687
186 4WB6 ATP 0.0000000001346 0.65057 26.5714
187 3FHI ANP 0.00000000006876 0.75503 26.8571
188 2QCS ANP 0.00000000009006 0.74994 26.8571
189 1RE8 BD2 0.00000002399 0.67948 26.8571
190 3IDB ANP 0.00000001921 0.60697 26.8571
191 5TA6 79D 0.00002346 0.46286 27.095
192 4Y85 499 0.00007286 0.49861 27.1084
193 1U59 STU 0.0000002338 0.60305 27.1777
194 3HMO STU 0.000001128 0.58028 27.4854
195 3E8N VRA 0.00000002043 0.46429 27.8592
196 3E8N ATP 0.00000002043 0.46429 27.8592
197 2GU8 796 0.00000001637 0.43024 27.8932
198 2CSN CKI 0.0000000004793 0.63302 27.9461
199 3TXO 07U 0.00000002177 0.59093 28.0453
200 4D2S DYK 0.000001481 0.5907 28.169
201 3GNI ATP 0.00000004608 0.61788 28.4182
202 1XJD STU 0.0000000225 0.63927 28.6957
203 1U5R ATP 0.000000008336 0.67644 29.023
204 5LI9 ACP 0.00000001081 0.65302 29.4286
205 3SXF BK5 0.0000001285 0.62839 29.4906
206 4Y93 746 0.000001281 0.52014 29.4906
207 4P5Z Q7M 0.00002959 0.41379 29.6399
208 4QMN DB8 0.000007899 0.43765 29.6774
209 3LXN MI1 0.000000001245 0.68419 29.8742
210 3LXK MI1 0.00000005136 0.55188 29.9694
211 4E93 GUI 0.0000001097 0.50852 30.0268
212 3PLS ANP 0.000000008768 0.61992 30.5369
213 2PVF ACP 0.000000000676 0.72566 30.5389
214 1BYG STU 0.00000002355 0.59443 30.5755
215 4OTH DRN 0.00000005467 0.6025 30.7918
216 5U6C 7YS 0.000001874 0.53954 30.7937
217 4DC2 ADE 0.000001476 0.45737 30.8311
218 5HES 032 0.00002311 0.50613 30.9446
219 4BHN BH9 0.00000001562 0.63774 31.4371
220 4GJ3 0XP 0.0000001059 0.62587 31.457
221 4E1Z 0MX 0.0000001853 0.57036 31.6151
222 3BU5 ATP 0.00000001826 0.61634 31.6993
223 2B9F ADP 0.000000004522 0.67866 31.728
224 4BTK DTQ 0.00001031 0.50668 31.7507
225 5JKG 6LF 0.00002792 0.52826 31.8328
226 4K33 ACP 0.0000000003424 0.71776 32
227 2B9J ADP 0.000000003411 0.69395 32.0113
228 2B9I ADP 0.000000004827 0.67741 32.0113
229 2B9H ADP 0.000000008658 0.63846 32.0113
230 2F2U M77 0.00000004519 0.67272 32.1716
231 4EWH T77 0.0000001302 0.53671 32.3636
232 4AT3 LTI 0.000003811 0.47191 32.4415
233 4XLI 1N1 0.00003013 0.51591 32.4627
234 4YMJ 4EJ 0.000006356 0.5896 32.5658
235 3EKK GS2 0.000001022 0.45943 32.5733
236 1K3A ACP 0.000002455 0.51243 32.7759
237 4TWP AXI 0.000001677 0.41288 32.8413
238 2OFV 242 0.00001093 0.54359 32.852
239 3NW7 LGV 0.000004612 0.57379 32.899
240 3RI1 3RH 0.0000002964 0.53431 32.9073
241 5HCY 60D 0.00000008897 0.45481 33.2326
242 5JFS 6K0 0.000002171 0.58166 33.4416
243 2A19 ANP 0.0000005883 0.61873 33.4507
244 3GQI ACP 0.000000002698 0.68855 33.7423
245 2HK5 1BM 0.000005541 0.52993 34.0741
246 3SXS PP2 0.000001209 0.55789 34.7015
247 5TO8 7FM 0.000007921 0.42321 34.7518
248 4CSV STI 0.001345 0.41706 34.9091
249 3SRV S19 0.00000001432 0.61034 35.0181
250 5UR1 YY9 0.00001458 0.40917 35.0482
251 5LI1 ANP 0.00000000003332 0.73263 35.3107
252 5HX8 66P 0.0000001417 0.54651 35.4305
253 4F4P 0SB 0.000008929 0.57319 35.5311
254 2ZV2 609 0.00000003548 0.67781 35.5705
255 3IGO ANP 0.000000003162 0.65202 35.9249
256 4I6H 1C8 0.0001774 0.47596 36.039
257 2V7O DRN 0.00000008501 0.54472 36.3095
258 4CRL C1I 0.0000004922 0.47803 37.1921
259 2WEL K88 0.000002627 0.46841 37.6147
260 4H3Q ANP 0.0000000002315 0.68173 38.3978
261 4H3P ANP 0.00000001347 0.62187 38.3978
262 3HZT J60 0.000001149 0.60464 38.6059
263 5UOX 8GY 0.00000002693 0.61431 38.7454
264 5H2U 1N1 0.00003245 0.50851 38.9513
265 5BVE 4VG 0.00000008944 0.40138 39.0582
266 5DA3 58V 0.0000003544 0.62939 39.2453
267 4YLL 4E3 0.00000000126 0.69084 39.3352
268 4QTB 38Z 0.000000005405 0.57776 39.6783
269 1CM8 ANP 0.00000008851 0.63015 39.782
270 5EKO N17 0.0001521 0.47343 39.8922
271 3GC8 B45 0.0000007288 0.5555 40
272 4LOO SB4 0.00001846 0.51933 40.1662
273 1PHK ATP 0.000000000009266 0.76077 40.2685
274 5FBN 5WF 0.000002155 0.57353 40.5904
275 2VN9 GVD 0.00000002263 0.55818 41.196
276 5BYZ 4WE 0.0000002675 0.50316 41.3793
277 2VZ6 FEF 0.00000008818 0.64862 41.5335
278 5N87 N66 0.0000003154 0.47855 41.5335
279 4NM5 ADP 0.0000003949 0.55561 42.8954
280 2JLD AG1 0.0000001294 0.50147 42.8954
281 4FG8 ATP 0.0000000002687 0.71235 43.1746
282 5EFQ ADP 0.000000005931 0.67346 43.5159
283 3TTI KBI 0.00000001012 0.57666 43.6997
284 4WHZ 3NL 0.0000006241 0.41454 43.6997
285 4NST ADP 0.000000005613 0.63599 44.1595
286 2WU6 DKI 0.0000000007632 0.66258 44.504
287 3PTG 932 0.000007005 0.47817 44.9036
288 3E7O 35F 0.00002243 0.43198 45
289 1O9U ADZ 0.000003823 0.59534 45.1429
290 5AWM ANP 0.00000002356 0.68642 45.3083
291 5HQ0 LZ9 0.000000003804 0.66368 45.3642
292 3F7Z 34O 0.0000002284 0.60349 45.7143
293 2BPM 529 0.00000004828 0.44621 46.6019
294 2WEI VGG 0.00001938 0.48091 46.6899
295 5LXC 7AA 0.00000000009903 0.67971 46.9169
296 4IZY 1J2 0.0000003969 0.57834 47.1545
297 4UX9 ANP 0.0000000004846 0.70152 47.2527
298 4AU8 Z3R 0.000002797 0.58593 47.2973
299 3GC0 AMP 0.00001255 0.48669 47.4164
300 4BCQ TJF 0.00000004146 0.67453 47.5083
301 4BCM T7Z 0.000002128 0.48439 47.5083
302 4BCN T9N 0.000000009027 0.69541 47.6667
303 3O0G 3O0 0.00000006126 0.58509 47.9452
304 1UNH IXM 0.0000000245 0.57642 47.9452
305 5X8I SQZ 0.0000000001067 0.75047 47.9769
306 5LMK 6ZK 0.00001142 0.54165 48.1481
307 4CFU 2WC 0.000000001992 0.71515 48.1848
308 2XMY CDK 0.000001163 0.62067 48.3221
Pocket No.: 2; Query (leader) PDB : 1Q8Y; Ligand: ADE; Similar sites found: 267
This union binding pocket(no: 2) in the query (biounit: 1q8y.bio2) has 18 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2YW2 ATP 0.0001799 0.4265 1.07239
2 2IO8 ADP 0.0001222 0.40809 1.07239
3 3X01 AMP 0.00003403 0.53486 1.60858
4 2R7K AMZ 0.001345 0.47367 1.66205
5 5DZT AMP 0.0001262 0.50339 1.87668
6 3WVR AMP 0.0001535 0.49833 1.87668
7 2VPQ ANP 0.0002122 0.50556 2.14477
8 2PUL ACP 0.000009843 0.50058 2.14477
9 4LH7 1X8 0.0003677 0.4869 2.16718
10 4ZS4 ATP 0.00001409 0.46563 2.28013
11 1ZB6 DIN 0.009506 0.43002 2.28013
12 1ZB6 GST 0.01009 0.43002 2.28013
13 4GYI ADP 0.00002361 0.50284 2.41287
14 4OCV ANP 0.0000383 0.46086 2.41287
15 5C1P ADP 0.0004775 0.44601 2.41287
16 2VQD AP2 0.00015 0.42655 2.41287
17 4ME6 ADP 0.00983 0.40919 2.41287
18 3PDT ADP 0.0001435 0.45807 2.54545
19 5COU ATP 0.002853 0.43899 2.64706
20 4P25 FUC GAL NAG FUC 0.007012 0.4104 2.64901
21 2R85 AMP 0.00439 0.45004 2.69461
22 3PN1 IVH 0.000625 0.45309 2.83019
23 2Q7D ANP 0.0001534 0.40819 2.89017
24 4CC6 L5Y 0.001795 0.43856 3.14465
25 3DNT ATP 0.00572 0.43535 3.21716
26 5K2M ADP 0.0001243 0.51927 3.2967
27 3HAV ATP 0.0001281 0.47467 3.34448
28 3VSV XYS 0.00268 0.44042 3.48525
29 1PK8 ATP 0.00005452 0.41237 3.48525
30 4FE2 ADP 0.00275 0.41356 3.52941
31 2PYW ADP 0.00002139 0.45822 3.75335
32 5IQD RIO 0.00005166 0.55903 3.93443
33 5IQD GNP 0.00004851 0.55903 3.93443
34 4PZ6 GMP 0.001539 0.41608 4.02145
35 1AUX AGS 0.00003456 0.46507 4.18006
36 1I7L ATP 0.0001541 0.40904 4.20712
37 2GQR ADP 0.003794 0.43294 4.21941
38 4CS9 AMP 0.00316 0.43814 4.2328
39 1IOW PHY 0.001468 0.47871 4.24837
40 1ZTH ADP 0.000007229 0.53763 4.26357
41 1ZP9 ATP 0.000004774 0.52039 4.26357
42 2QK4 ATP 0.0006707 0.45886 4.28954
43 5FI4 5XV 0.0223 0.40537 4.28954
44 1TZD ADP 0.001208 0.40747 4.36364
45 2IF8 ADP 0.0001599 0.49551 4.40771
46 5HCF BGC 0.01145 0.41152 4.42804
47 3ETH ATP 0.0004561 0.48688 4.50704
48 2QF7 AGS 0.02589 0.40623 4.55764
49 3I0O ADP 0.00005168 0.49749 4.71976
50 3UDZ ADP 0.000001294 0.6085 4.82574
51 1W2D ADP 0.0005931 0.45195 4.90566
52 1GSA ADP 0.0000532 0.53572 5.06329
53 4O1P ANP 0.0000001931 0.64609 5.09383
54 5TDF ADP 0.0002545 0.49739 5.09383
55 5VZ0 ADP 0.0001115 0.45446 5.09383
56 3TII ANP 0.0041 0.42417 5.09383
57 1OBD ATP 0.0005976 0.44528 5.22876
58 5IGI GMP 0.00601 0.44902 5.31561
59 5IGI ZIT 0.006308 0.44902 5.31561
60 1M0W ANP 0.0001629 0.49708 5.36193
61 4AZW ATP 0.0004064 0.48729 5.36193
62 4U98 ACP 0.0002131 0.44556 5.36193
63 4AZT LY2 0.002018 0.42652 5.36193
64 5GZ9 ANP 0.000001904 0.6083 5.57377
65 4GLW 0XT 0.001452 0.44293 5.57377
66 3T1A 5MA 0.02076 0.40044 5.63003
67 4WW7 AMP 0.00001224 0.56536 5.88235
68 4CYI ATP 0.000003288 0.59124 5.89812
69 3VOT ADP 0.0003477 0.47549 5.89812
70 2Z48 NGA 0.01286 0.40164 5.89812
71 2BKK ADP 0.00519 0.42174 6.06061
72 2ZL7 FUC GAL NGA 0.01408 0.40152 6.1017
73 1EHI ADP 0.0008137 0.4005 6.16622
74 1NZY BCA 0.03452 0.40102 6.3197
75 1JXZ BCA 0.03538 0.40046 6.3197
76 3VPD ANP 0.0002338 0.50137 6.40569
77 5MW8 ATP 0.000001001 0.62233 6.70241
78 2CFM AMP 0.003335 0.41788 6.70241
79 3LQV ADE 0.004474 0.44863 6.95652
80 1TQP ATP 0.00001785 0.43175 7.0922
81 3PNA CMP 0.007266 0.40966 7.14286
82 4OUJ LBT 0.007406 0.42083 7.16612
83 3TDV GDP 0.00006752 0.4539 7.18954
84 4R78 AMP 0.00123 0.44635 7.76699
85 5JSP DQY 0.0151 0.40114 7.9602
86 4XYM A12 0.00006166 0.4503 8.26087
87 4I42 1HA 0.03038 0.40514 8.42105
88 4IX4 ADP 0.00004104 0.53677 8.57143
89 3H9R TAK 0.00002154 0.52978 8.78788
90 5AHW CMP 0.01623 0.40197 8.84354
91 4DFU QUE 0.0008841 0.45924 9.00621
92 5C4L 4XR 0.00002429 0.5667 9.34579
93 5C4L SIS 0.0004141 0.50306 9.34579
94 5I35 ANP 0.000001965 0.51983 9.38338
95 2HGS ADP 0.0001756 0.50969 9.38338
96 1VJY 460 0.000002272 0.41472 9.90099
97 5VC5 96M 0.000002762 0.44051 10.0346
98 3FW4 CAQ 0.02752 0.40215 10.1124
99 5KO1 6UY 0.000001195 0.52697 10.2473
100 4RDL FUC GAL NDG FUC 0.001754 0.44881 11.6883
101 1IA9 ANP 0.00001223 0.47057 11.7857
102 2GQS ADP 0.003679 0.43359 12.2363
103 3C1X CKK 0.000006413 0.45956 12.3324
104 5C8W PCG 0.004164 0.42118 12.5874
105 1VBO MAN MAN MAN 0.01297 0.40391 12.7517
106 4Q5H ANP 0.00002266 0.47632 13.2184
107 5LPZ ADP 0.0000001278 0.55756 13.253
108 5ML3 DL3 0.009271 0.44018 13.4228
109 3VHE 42Q 0.000001144 0.42973 13.649
110 4U0I 0LI 0.00002238 0.56854 13.6508
111 4OAV ACP 0.0000004815 0.55025 13.6729
112 3UIM ANP 0.0000001848 0.55135 13.8037
113 4ASE AV9 0.0000003757 0.65365 13.881
114 5USZ SKE 0.000004831 0.43705 13.941
115 4IDT T28 0.000006825 0.50158 14.0449
116 2OO8 RAJ 0.0001336 0.51352 14.1956
117 4WNK 453 0.0000004712 0.44784 14.2091
118 5EOB 5QQ 0.000002464 0.6479 14.4201
119 4BKJ STI 0.00001504 0.42767 14.6032
120 2X2M X2M 0.000001608 0.48553 14.6497
121 5LPB ADP 0.0000003573 0.59601 14.8649
122 4FL3 ANP 0.000002057 0.48689 15.1181
123 5T8O 76Z 0.000002102 0.48201 15.1862
124 5CKW ANP 0.00006293 0.49611 15.5496
125 3ALN ANP 0.000002313 0.48487 16.208
126 5CEO 50D 0.00001502 0.55318 16.6667
127 4WOV 3SM 0.000257 0.459 17.3502
128 5JGA 6KC 0.00000556 0.41002 17.4603
129 1ZY5 ANP 0.000001794 0.52657 17.4917
130 2QLU ADE 0.00001235 0.55593 17.5159
131 3KMW ATP 0.0000443 0.47217 17.7122
132 4XH0 ADP 0.0000001776 0.64661 17.9625
133 5UKL SIX 0.000002082 0.61567 19.3029
134 3PVW QRX 0.0000003429 0.47487 19.3029
135 2XVD AS6 0.00001608 0.57226 20.5298
136 5DBX ANP 0.00000005554 0.6614 21.0366
137 3VPC ADP 0.00006131 0.43017 21.2766
138 3VPB ADP 0.00003914 0.41786 21.2766
139 4L9I 8PR 0.000002044 0.52096 22.5201
140 5C03 AGS 0.000002506 0.50597 22.807
141 5MJA 7O3 0.000002477 0.52864 22.9508
142 1JPA ANP 0.00001428 0.42854 23.3974
143 4YZC STU 0.0000002668 0.67771 23.8606
144 3PP0 03Q 0.0000027 0.43816 23.8606
145 3VRY B43 0.000005216 0.44595 24.6649
146 4WB7 ATP 0.0000006434 0.41123 24.6649
147 3SLS ANP 0.000001759 0.48633 25
148 2H8H H8H 0.00003549 0.53482 25.2011
149 1Y57 MPZ 0.00002628 0.44483 25.2011
150 4KBA 1QM 0.00002288 0.41971 25.3776
151 4CLI 5P8 0.000001366 0.64994 25.7373
152 2Y6O 1N1 0.0000006637 0.49615 25.7732
153 2F57 23D 0.000003946 0.5256 26.183
154 3KRL KRL 0.0000009584 0.48948 26.2687
155 4WB6 ATP 0.00000003131 0.4973 26.5714
156 2QCS ANP 0.00000002126 0.71475 26.8571
157 3FHI ANP 0.00000002753 0.70904 26.8571
158 1RE8 BD2 0.000001055 0.65882 26.8571
159 3IDB ANP 0.0000003838 0.49405 26.8571
160 5TA6 79D 0.000002006 0.44894 27.095
161 4Y85 499 0.0002038 0.44209 27.1084
162 1U59 STU 0.000000345 0.53265 27.1777
163 3HMO STU 0.0000007529 0.53551 27.4854
164 2CSN CKI 0.0000002216 0.4734 27.9461
165 3TXO 07U 0.0000002524 0.63346 28.0453
166 4D2S DYK 0.000004566 0.53193 28.169
167 3GNI ATP 0.000001156 0.49448 28.4182
168 1XJD STU 0.0000004534 0.52465 28.6957
169 1U5R ATP 0.00000004903 0.58282 29.023
170 5LI9 ACP 0.0000002201 0.54069 29.4286
171 3SXF BK5 0.0000004976 0.65984 29.4906
172 4Y93 746 0.00003104 0.42811 29.4906
173 4QMN DB8 0.00000003672 0.44053 29.6774
174 3LXN MI1 0.00000003414 0.5489 29.8742
175 3LXK MI1 0.0000007771 0.45577 29.9694
176 4E93 GUI 0.000002627 0.42298 30.0268
177 3PLS ANP 0.00000002605 0.68518 30.5369
178 2PVF ACP 0.00000003367 0.58924 30.5389
179 1BYG STU 0.00000094 0.60574 30.5755
180 4OTH DRN 0.0000007787 0.49794 30.7918
181 5U6C 7YS 0.000005375 0.47369 30.7937
182 4DC2 ADE 0.0000005975 0.5542 30.8311
183 5HES 032 0.00001152 0.56668 30.9446
184 4BHN BH9 0.000003511 0.48457 31.4371
185 4GJ3 0XP 0.0000002072 0.67359 31.457
186 4E1Z 0MX 0.0000008928 0.48415 31.6151
187 3BU5 ATP 0.0000000734 0.66674 31.6993
188 2B9F ADP 0.00000008972 0.56468 31.728
189 4BTK DTQ 0.000006912 0.56974 31.7507
190 5JKG 6LF 0.000006932 0.60499 31.8328
191 4K33 ACP 0.0000001138 0.5418 32
192 2B9H ADP 0.0000001783 0.65104 32.0113
193 2B9J ADP 0.0000001667 0.56835 32.0113
194 2B9I ADP 0.0000002745 0.5486 32.0113
195 2F2U M77 0.000001473 0.56908 32.1716
196 4EWH T77 0.0000009494 0.45322 32.3636
197 4AT3 LTI 0.000003052 0.42452 32.4415
198 4XLI 1N1 0.000006444 0.50638 32.4627
199 4YMJ 4EJ 0.0000000117 0.70584 32.5658
200 3EKK GS2 0.0000009424 0.41351 32.5733
201 1K3A ACP 0.000001663 0.59023 32.7759
202 2OFV 242 0.00006143 0.55218 32.852
203 3NW7 LGV 0.00001047 0.60532 32.899
204 3RI1 3RH 0.00001184 0.43374 32.9073
205 5JFS 6K0 0.0000006634 0.662 33.4416
206 2A19 ANP 0.0000003332 0.59803 33.4507
207 3GQI ACP 0.000000668 0.52592 33.7423
208 2HK5 1BM 0.00001259 0.56227 34.0741
209 3SXS PP2 0.0000001939 0.51671 34.7015
210 5TO8 7FM 0.0000006388 0.40225 34.7518
211 4CSV STI 0.00001082 0.44872 34.9091
212 3SRV S19 0.00000008503 0.66009 35.0181
213 5UR1 YY9 0.000000783 0.43661 35.0482
214 5LI1 ANP 0.0000000482 0.53611 35.3107
215 5HX8 66P 0.0000007273 0.4647 35.4305
216 4F4P 0SB 0.00008324 0.5684 35.5311
217 2ZV2 609 0.00000009862 0.62112 35.5705
218 3IGO ANP 0.00000002172 0.5398 35.9249
219 4I6H 1C8 0.00001003 0.4851 36.039
220 2V7O DRN 0.000000004027 0.70682 36.3095
221 4CRL C1I 0.0000003877 0.42733 37.1921
222 2WEL K88 0.00000007776 0.61075 37.6147
223 4H3P ANP 0.00000008064 0.66473 38.3978
224 4H3Q ANP 0.0000007225 0.48756 38.3978
225 3HZT J60 0.000000005955 0.67408 38.6059
226 5UOX 8GY 0.000001089 0.48809 38.7454
227 5H2U 1N1 0.000003417 0.5004 38.9513
228 5DA3 58V 0.000000206 0.60662 39.2453
229 4YLL 4E3 0.0000000577 0.68452 39.3352
230 4QTB 38Z 0.0000002536 0.45795 39.6783
231 1CM8 ANP 0.000003272 0.51061 39.782
232 5EKO N17 0.000005135 0.58668 39.8922
233 3GC8 B45 0.000008953 0.45544 40
234 4LOO SB4 0.0000298 0.46579 40.1662
235 1PHK ATP 0.000000005181 0.72699 40.2685
236 5FBN 5WF 0.00011 0.53747 40.5904
237 2VN9 GVD 0.00000001043 0.68718 41.196
238 2VZ6 FEF 0.000003525 0.53533 41.5335
239 5N87 N66 0.000002291 0.40517 41.5335
240 4NM5 ADP 0.0000006525 0.49152 42.8954
241 2JLD AG1 0.000001616 0.42211 42.8954
242 4FG8 ATP 0.00000005756 0.54154 43.1746
243 5EFQ ADP 0.00000007133 0.56519 43.5159
244 3TTI KBI 0.000003513 0.44225 43.6997
245 4NST ADP 0.0000001525 0.65113 44.1595
246 2WU6 DKI 0.00000001192 0.53876 44.504
247 3PTG 932 0.000008474 0.54902 44.9036
248 3E7O 35F 0.000003402 0.40671 45
249 1O9U ADZ 0.00000001912 0.69089 45.1429
250 5AWM ANP 0.0000006826 0.58299 45.3083
251 5HQ0 LZ9 0.0000003307 0.52056 45.3642
252 3F7Z 34O 0.0000002149 0.54739 45.7143
253 2WEI VGG 0.000008405 0.55957 46.6899
254 5LXC 7AA 0.000000002514 0.73061 46.9169
255 4IZY 1J2 0.000000006797 0.56891 47.1545
256 4UX9 ANP 0.0000001244 0.52884 47.2527
257 4AU8 Z3R 0.00001521 0.5245 47.2973
258 3GC0 AMP 0.00002347 0.53482 47.4164
259 4BCM T7Z 0.000001042 0.5804 47.5083
260 4BCQ TJF 0.000005114 0.54477 47.5083
261 4BCN T9N 0.0000003361 0.58082 47.6667
262 1UNH IXM 0.000001081 0.59924 47.9452
263 3O0G 3O0 0.000001781 0.59556 47.9452
264 5X8I SQZ 0.00000000918 0.59463 47.9769
265 5LMK 6ZK 0.00007767 0.47081 48.1481
266 4CFU 2WC 0.00000008791 0.58693 48.1848
267 2XMY CDK 0.000001654 0.66725 48.3221
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