Receptor
PDB id Resolution Class Description Source Keywords
2J0V 1.78 Å NON-ENZYME: BINDING THE CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA RAC7-ROP9: THE FIRST RAS SUPERFAMILY GTPASE FROM THE PLANT KINGDOM ARABIDOPSIS THALIANA NUCLEOTIDE-BINDING PROTEIN ROP9 ATRAC7 MEMBRANE PALMITATE RHO GTPASE ABSCISIC ACID SIGNALING PATHWAY DNA BINDING PROTEIN NUCLEOTIDE- BINDING ARABIDOPSIS THALIANA LIPOPROTEIN GTP-BINDING RAS SUPERFAMILY
Ref.: THE CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA RAC7/ROP9: THE FIRST RAS SUPERFAMILY GTPASE FROM THE PLANT KINGDOM. PHYTOCHEMISTRY V. 67 2332 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GDP A:1179;
B:1182;
C:1178;
D:1180;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
443.201 C10 H15 N5 O11 P2 c1nc2...
MG A:1180;
B:1183;
C:1179;
D:1181;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2J0V 1.78 Å NON-ENZYME: BINDING THE CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA RAC7-ROP9: THE FIRST RAS SUPERFAMILY GTPASE FROM THE PLANT KINGDOM ARABIDOPSIS THALIANA NUCLEOTIDE-BINDING PROTEIN ROP9 ATRAC7 MEMBRANE PALMITATE RHO GTPASE ABSCISIC ACID SIGNALING PATHWAY DNA BINDING PROTEIN NUCLEOTIDE- BINDING ARABIDOPSIS THALIANA LIPOPROTEIN GTP-BINDING RAS SUPERFAMILY
Ref.: THE CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA RAC7/ROP9: THE FIRST RAS SUPERFAMILY GTPASE FROM THE PLANT KINGDOM. PHYTOCHEMISTRY V. 67 2332 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 2J0V - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 2J0V - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 2W2T - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 3REF - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 2J0V - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GDP; Similar ligands found: 161
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 1 1
2 GTP 0.909091 1
3 GP3 0.881579 0.973684
4 GNH 0.858974 0.986667
5 9GM 0.839506 0.973684
6 GNP 0.839506 0.973684
7 G 0.828947 0.986486
8 5GP 0.828947 0.986486
9 G1R 0.82716 0.986667
10 GCP 0.82716 0.973684
11 GSP 0.817073 0.948718
12 GAV 0.797619 0.961039
13 GMV 0.792683 0.973684
14 G2P 0.77381 0.961039
15 G2R 0.770115 0.961039
16 GP2 0.756098 0.961039
17 GDC 0.747253 0.961039
18 GKE 0.747253 0.961039
19 GDD 0.747253 0.961039
20 GPG 0.741573 0.961039
21 G3D 0.732558 0.986486
22 ALF 5GP 0.729412 0.888889
23 Y9Z 0.728261 0.902439
24 G5P 0.723404 0.973684
25 GFB 0.72043 0.961039
26 GTG 0.72043 0.936709
27 GDR 0.72043 0.961039
28 G4P 0.715909 0.986486
29 G3A 0.712766 0.973684
30 6CK 0.712766 0.936709
31 GDP AF3 0.7 0.888889
32 ALF GDP 0.7 0.888889
33 GDP ALF 0.7 0.888889
34 YGP 0.698925 0.901235
35 GKD 0.697917 0.961039
36 JB2 0.697917 0.961039
37 GDX 0.690722 0.973684
38 GPD 0.690722 0.925
39 GMP 0.684211 0.88
40 0O2 0.666667 0.986486
41 JB3 0.656863 0.948718
42 NGD 0.650485 0.961039
43 DGI 0.636364 0.923077
44 GDP 7MG 0.636364 0.911392
45 U2G 0.634615 0.936709
46 GPX 0.634409 0.946667
47 G G 0.632653 0.948052
48 IDP 0.632184 0.972973
49 2MD 0.632075 0.891566
50 CAG 0.62963 0.880952
51 CG2 0.622642 0.936709
52 FEG 0.619048 0.879518
53 MGD 0.614679 0.891566
54 ZGP 0.613208 0.869048
55 GH3 0.612903 0.973333
56 3GP 0.611765 0.946667
57 MD1 0.607143 0.891566
58 PGD 0.59292 0.925
59 DGT 0.591398 0.923077
60 BGO 0.588785 0.924051
61 TPG 0.582609 0.840909
62 DBG 0.582609 0.948718
63 2GP 0.574713 0.96
64 FE9 0.570175 0.776596
65 GCP G 0.56 0.921053
66 A G 0.553571 0.935065
67 G A A A 0.553571 0.923077
68 MGP 0.553191 0.961039
69 U A G G 0.548673 0.935065
70 G4M 0.548387 0.880952
71 6G0 0.547368 0.961039
72 G1R G1R 0.542373 0.924051
73 P2G 0.527473 0.883117
74 PGD O 0.525 0.850575
75 ADP 0.522222 0.92
76 R5I 0.520833 0.946667
77 R7I 0.520833 0.946667
78 GGM 0.517544 0.901235
79 DGP 0.516484 0.910256
80 DG 0.516484 0.910256
81 P1G 0.516129 0.871795
82 G U 0.513274 0.9
83 G1G 0.508475 0.925
84 IMP 0.505495 0.959459
85 AKW 0.504425 0.890244
86 G C 0.504348 0.9
87 GPC 0.491525 0.879518
88 G7M 0.483871 0.948052
89 6AD 0.479592 0.841463
90 ATP 0.473684 0.92
91 HEJ 0.473684 0.92
92 G2Q 0.471154 0.961039
93 5FA 0.46875 0.92
94 AQP 0.46875 0.92
95 GTA 0.468468 0.936709
96 7DD 0.468085 0.906667
97 G G G RPC 0.466102 0.875
98 SGP 0.463158 0.82716
99 01G 0.462963 0.902439
100 HFD 0.459184 0.873418
101 B4P 0.457447 0.894737
102 AP5 0.457447 0.894737
103 A2D 0.456522 0.894737
104 6YZ 0.455446 0.896104
105 G G G C 0.455285 0.9125
106 5GP 5GP 0.454545 0.883117
107 ANP 0.454545 0.896104
108 ACQ 0.454545 0.896104
109 AT4 0.452632 0.884615
110 A G C C 0.451613 0.911392
111 APC G U 0.45082 0.886076
112 PRT 0.449541 0.959459
113 G U34 0.449153 0.888889
114 DG DG 0.448598 0.865854
115 ITT 0.447917 0.868421
116 BA3 0.446809 0.894737
117 C2E 0.444444 0.921053
118 PCG 0.444444 0.933333
119 35G 0.444444 0.933333
120 MGO 0.441176 0.864198
121 AN2 0.4375 0.907895
122 G C C C 0.4375 0.924051
123 M33 0.43299 0.883117
124 UCG 0.429688 0.911392
125 A G U 0.42963 0.888889
126 ACP 0.428571 0.896104
127 MGQ 0.424528 0.935897
128 AR6 0.424242 0.894737
129 7DT 0.424242 0.906667
130 APR 0.424242 0.894737
131 93A 0.42268 0.833333
132 A4P 0.420168 0.869048
133 G8D 0.42 0.875
134 AD9 0.42 0.896104
135 SAP 0.42 0.873418
136 AGS 0.42 0.873418
137 CA0 0.418367 0.896104
138 ATF 0.417476 0.884615
139 AGO 0.414634 0.888889
140 A G U U 0.414286 0.888889
141 NIA 0.413043 0.82716
142 MGV 0.412844 0.890244
143 TAT 0.411765 0.884615
144 T99 0.411765 0.884615
145 ADQ 0.411215 0.871795
146 A1R 0.411215 0.839506
147 RGT 0.410714 0.909091
148 CGP 0.409836 0.86747
149 C1Z 0.409091 0.986486
150 A 0.408602 0.893333
151 AMP 0.408602 0.893333
152 UP5 0.40678 0.873418
153 AMZ 0.406593 0.918919
154 C2R 0.406593 0.906667
155 JBT 0.405882 0.778947
156 A22 0.40566 0.907895
157 25L 0.405405 0.907895
158 ADX 0.40404 0.809524
159 8OD 0.401961 0.946667
160 50T 0.4 0.883117
161 4TC 0.4 0.851852
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2J0V; Ligand: GDP; Similar sites found with APoc: 74
This union binding pocket(no: 1) in the query (biounit: 2j0v.bio3) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 4NON GDP 2.35849
2 1SVI GDP 3.58974
3 3U6B GDP 4.24528
4 5KUT GDP 5.29101
5 2X77 GDP 13.2275
6 3DOE GTP 14.5833
7 2RCN GDP 14.6226
8 1KSH GDP 15.0538
9 1R4A GNP 17.5758
10 4ZI2 GNP 24.7368
11 1ZD9 GDP 27.1277
12 3GJ7 GDP 29.2453
13 3GJ4 GDP 29.2453
14 3GJ8 GDP 29.2453
15 3GJ5 GDP 29.2453
16 4HAT GNP 29.717
17 3M1I GTP 29.717
18 3WYF GTP 29.717
19 5BXQ GDP 29.717
20 3GJ0 GDP 29.717
21 3CH5 GDP 29.717
22 3GJ3 GDP 29.717
23 5UWP GNP 32.0755
24 5UWO GNP 32.0755
25 5UWQ GNP 32.0755
26 5UWU GNP 32.0755
27 6CIT GNP 32.0755
28 5UWJ GNP 32.0755
29 5UWI GNP 32.0755
30 5UWR GNP 32.0755
31 5UWW GNP 32.0755
32 5UWH GNP 32.0755
33 5DHF GNP 32.0755
34 5UWT GNP 32.0755
35 5UWS GNP 32.0755
36 2G77 GDP 33.8384
37 3WYG GTP 34.6154
38 3Q72 GNP 35.5422
39 5XC5 GTP 35.7955
40 1WA5 GTP 35.7955
41 1Z06 GNP 36.5079
42 3E5H GNP 37.0787
43 4DKX GDP 39.1509
44 1YZN GNP 40
45 3CPJ GDP 41.0377
46 5OEC GDP 42.623
47 5LEF GTP 43.9791
48 5SZH GNP 44.335
49 1OIX GDP 44.5026
50 1OIV GDP 45.0262
51 3TKL GTP 45.4082
52 2EW1 GNP 45.7711
53 1VG0 GDP 45.8937
54 3BC1 GNP 46.1538
55 2EFE GNH 46.4088
56 1Z0K GTP 46.5116
57 1VG9 GDP 47.027
58 1VG1 GDP 47.027
59 2A9K GDP 47.0588
60 2A5J GDP 47.1204
61 5DIF GNP 47.3684
62 1TU3 GNP 47.3684
63 3MJH GTP 47.619
64 1Z0J GTP 47.6471
65 1ZC3 GNP 48
66 5JCZ GDP 48.0447
67 1Z2A GDP 48.2143
68 1YVD GNP 48.5207
69 1UAD GNP 48.5714
70 3SFV GDP 48.6188
71 1YZQ GNP 49.4118
72 2HV8 GTP 49.4186
73 2BME GNP 49.4624
74 4C4P GNP 49.711
75 1U8Z GDP 50
Pocket No.: 2; Query (leader) PDB : 2J0V; Ligand: GDP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2j0v.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2J0V; Ligand: GDP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2j0v.bio4) has 17 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2J0V; Ligand: GDP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2j0v.bio2) has 17 residues
No: Leader PDB Ligand Sequence Similarity
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