Receptor
PDB id Resolution Class Description Source Keywords
2J0B 2.1 Å EC: 2.4.1.222 STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE MUS MUSCULUS GLYCOSYLTRANSFERASE DEVELOPMENTAL PROTEIN TRANSMEMBRANE GAPPARATUS NOTCH SIGNALING MEMBRANE TRANSFERASE GLYCOPROSIGNAL-ANCHOR
Ref.: STRUCTURAL INSIGHTS INTO THE NOTCH-MODIFYING GLYCOSYLTRANSFERASE FRINGE NAT.STRUCT.MOL.BIOL. V. 13 945 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
K A:1320;
Part of Protein;
none;
submit data
39.098 K [K+]
MN A:1321;
Part of Protein;
none;
submit data
54.938 Mn [Mn+2...
SO4 A:1319;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
UDP A:1322;
Valid;
none;
submit data
404.161 C9 H14 N2 O12 P2 C1=CN...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2J0B 2.1 Å EC: 2.4.1.222 STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE MUS MUSCULUS GLYCOSYLTRANSFERASE DEVELOPMENTAL PROTEIN TRANSMEMBRANE GAPPARATUS NOTCH SIGNALING MEMBRANE TRANSFERASE GLYCOPROSIGNAL-ANCHOR
Ref.: STRUCTURAL INSIGHTS INTO THE NOTCH-MODIFYING GLYCOSYLTRANSFERASE FRINGE NAT.STRUCT.MOL.BIOL. V. 13 945 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2J0B - UDP C9 H14 N2 O12 P2 C1=CN(C(=O....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2J0B - UDP C9 H14 N2 O12 P2 C1=CN(C(=O....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2J0B - UDP C9 H14 N2 O12 P2 C1=CN(C(=O....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: UDP; Similar ligands found: 116
No: Ligand ECFP6 Tc MDL keys Tc
1 UDP 1 1
2 UTP 0.892308 1
3 UNP 0.8 0.970149
4 U5P 0.78125 0.984615
5 UPU 0.72973 0.940298
6 2KH 0.722222 0.970149
7 44P 0.720588 0.955882
8 URM 0.717949 0.927536
9 GUD 0.717949 0.941176
10 GDU 0.717949 0.941176
11 UFM 0.717949 0.941176
12 UPG 0.717949 0.941176
13 660 0.717949 0.927536
14 UDP UDP 0.714286 0.939394
15 UDH 0.705128 0.864865
16 UPP 0.705128 0.941176
17 UPF 0.691358 0.888889
18 U2F 0.691358 0.888889
19 UFG 0.691358 0.888889
20 UDX 0.670732 0.941176
21 UAD 0.670732 0.941176
22 3UC 0.658824 0.888889
23 USQ 0.654762 0.820513
24 UGB 0.654762 0.955224
25 UGA 0.654762 0.955224
26 G3N 0.647059 0.914286
27 UDM 0.636364 0.914286
28 URI 0.625 0.863636
29 U 0.625 0.863636
30 UD1 0.622222 0.927536
31 UD2 0.622222 0.927536
32 UDP GAL 0.611765 0.913043
33 Y6W 0.607143 0.888889
34 CDP 0.605263 0.942029
35 UD7 0.591398 0.927536
36 HP7 0.591398 0.941176
37 MJZ 0.585106 0.914286
38 IUG 0.583333 0.810127
39 12V 0.578947 0.901408
40 HWU 0.578947 0.901408
41 UD4 0.578947 0.914286
42 CJB 0.573529 0.820895
43 UDZ 0.571429 0.853333
44 DUD 0.571429 0.913043
45 UP5 0.571429 0.853333
46 U U 0.563218 0.955224
47 EPZ 0.56 0.914286
48 5GW 0.559524 0.942029
49 EPU 0.554455 0.901408
50 EEB 0.554455 0.901408
51 UA3 0.547945 0.939394
52 U3P 0.547945 0.939394
53 CH 0.546667 0.913043
54 4TC 0.544554 0.831169
55 CTP 0.54321 0.942029
56 CSV 0.531915 0.851351
57 CSQ 0.531915 0.851351
58 DUT 0.52439 0.913043
59 4GW 0.516484 0.915493
60 UMA 0.513761 0.914286
61 U4S 0.513158 0.753425
62 U2P 0.506667 0.954545
63 U2S 0.5 0.767123
64 U3S 0.5 0.753425
65 PUP 0.48913 0.913043
66 U22 0.486957 0.790123
67 U21 0.486957 0.810127
68 U20 0.486957 0.810127
69 DKX 0.486486 0.746479
70 U1S 0.482759 0.75
71 A U 0.481132 0.805195
72 2QR 0.478632 0.822785
73 5FU 0.474359 0.914286
74 8OD 0.47191 0.851351
75 C5G 0.468085 0.888889
76 7XL 0.465909 0.888889
77 U U U U 0.461538 0.940298
78 UMF 0.461538 0.857143
79 G8D 0.460674 0.855263
80 UTP U U U 0.456522 0.895522
81 2TU 0.452055 0.774648
82 4RA 0.451613 0.855263
83 C2G 0.450549 0.901408
84 DU 0.45 0.898551
85 CAR 0.45 0.927536
86 C 0.45 0.927536
87 C5P 0.45 0.927536
88 UMP 0.45 0.898551
89 UAG 0.448 0.864865
90 CDC 0.446809 0.777778
91 UD0 0.444444 0.844156
92 5BU 0.444444 0.914286
93 N3E 0.440476 0.733333
94 UC5 0.440476 0.9
95 UUA 0.438356 0.772727
96 DUP 0.431818 0.887324
97 2GW 0.431373 0.901408
98 M7G 0.430108 0.780488
99 CNU 0.428571 0.927536
100 CDM 0.427083 0.842105
101 H6Y 0.425532 0.851351
102 16B 0.421687 0.888889
103 S5P 0.419753 0.915493
104 8GT 0.419355 0.855263
105 CXY 0.418367 0.888889
106 UPA 0.418182 0.842105
107 CDP MG 0.413793 0.849315
108 U2G 0.410714 0.822785
109 U A A U 0.409836 0.842105
110 UML 0.408759 0.810127
111 UP6 0.407407 0.871429
112 M7M 0.40625 0.771084
113 PMP UD1 0.404762 0.794872
114 1GW 0.40367 0.864865
115 BMP 0.402439 0.970149
116 APU 0.401786 0.828947
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2J0B; Ligand: UDP; Similar sites found: 80
This union binding pocket(no: 1) in the query (biounit: 2j0b.bio1) has 10 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5GXU FMN 0.008217 0.41308 1.78571
2 1GKZ ADP 0.02298 0.40383 1.78571
3 3VPD ANP 0.02247 0.40034 1.78571
4 1U1F 183 0.03635 0.4218 1.95312
5 5UN9 NHT 0.006631 0.42728 2.14286
6 2QZZ NAP 0.02522 0.42324 2.14286
7 2QZZ EMF 0.02614 0.42324 2.14286
8 5KVS 6XR 0.01925 0.41467 2.14286
9 1QFY FAD 0.0364 0.41065 2.14286
10 1QFY NAP 0.0364 0.41065 2.14286
11 5KVS NAP 0.01706 0.40778 2.14286
12 1KEW NAD 0.03578 0.40399 2.14286
13 1KEW TYD 0.03994 0.40215 2.14286
14 1YP4 ADP 0.01365 0.40023 2.14286
15 3WV8 ATP 0.03481 0.40564 2.29358
16 5MF5 C2E 0.01669 0.41506 2.34375
17 2BO4 FLC 0.008355 0.43874 2.5
18 2I6U NVA 0.01251 0.40501 2.5
19 3CU0 GAL GAL SO4 0.003044 0.45064 2.85714
20 3CU0 UDP 0.001415 0.45064 2.85714
21 5A6N U7E 0.00722 0.43936 2.85714
22 5AJP UDP 0.005341 0.42813 2.85714
23 4UUG PXG 0.01641 0.42752 2.85714
24 4BVA NDP 0.03982 0.40779 2.85714
25 2WJH FLC 0.01264 0.4031 3.01205
26 5AGR A52 0.02079 0.4004 3.01724
27 1N07 ADP 0.01861 0.40499 3.06748
28 4JK3 NAD 0.0375 0.40962 3.0888
29 2APC UDM 0.0001608 0.51822 3.21429
30 1J0X NAD 0.02882 0.43215 3.21429
31 2GVV DI9 0.006964 0.42136 3.21429
32 3DAG FEG 0.02001 0.41925 3.21429
33 3CIF G3H 0.03064 0.41889 3.21429
34 4I42 1HA 0.0218 0.41872 3.21429
35 3CIF NAD 0.02432 0.41842 3.21429
36 2YAB AMP 0.01693 0.41453 3.21429
37 5K2M ADP 0.02172 0.41109 3.2967
38 5G5G MCN 0.03168 0.4201 3.57143
39 3C0G 3AM 0.03114 0.40021 3.57143
40 4KQL 1SG 0.01569 0.42697 3.92857
41 4M7V RAR 0.002387 0.49469 4
42 4M7V NAP 0.001412 0.49469 4
43 5HR5 FLC 0.008254 0.45174 4.28571
44 1GAD NAD 0.02455 0.40009 4.28571
45 1R6D DAU 0.004817 0.45927 4.64286
46 3QV1 NAD 0.01724 0.41773 4.64286
47 3L6R MLI 0.005673 0.40818 4.64286
48 2QGI UDP 0.001931 0.40497 4.83871
49 4OR7 NAP 0.0006435 0.51839 4.84848
50 1G8K MGD 0.03977 0.42849 5.26316
51 2NZU BG6 0.002658 0.44016 5.35714
52 5K3W PLP 0.01918 0.41461 5.35714
53 2AMT 1AA 0.03043 0.40206 5.66038
54 1TLL FMN 0.002637 0.45289 5.71429
55 1PHK ATP 0.01183 0.42529 5.71429
56 5DEY 59T 0.03127 0.41305 5.71429
57 4N9Z V3L 0.02037 0.40413 5.71429
58 2QRD ATP 0.02461 0.40711 6.18557
59 3PJU C2E 0.008008 0.45121 6.4257
60 2J62 GSZ 0.007592 0.4451 6.42857
61 2P4T NAP 0.01276 0.40988 6.45161
62 5F05 GSH 0.01153 0.40536 6.60377
63 4Q3F TLA 0.009358 0.40556 6.83761
64 3CMC NAD 0.047 0.43164 7.14286
65 2BZ1 TAU 0.002587 0.40183 7.14286
66 5DXV NAP 0.0007384 0.5028 7.5
67 2V3V MGD 0.03518 0.43417 7.5
68 4WB6 ATP 0.01893 0.41253 8.21429
69 5UAV TFB 0.04921 0.40617 8.21429
70 5UAV NDP 0.04921 0.40617 8.21429
71 5AHO TLA 0.001386 0.45078 9.28571
72 3K8D CTP 0.002445 0.43995 9.4697
73 1DR1 NAP 0.005472 0.46441 12.1693
74 1DR1 HBI 0.005472 0.46441 12.1693
75 5SWB NAG BMA MAN MAN MAN MAN 0.02276 0.41868 13.2143
76 1V84 UDP 0.0008578 0.40272 13.4387
77 5H86 BCO 0.03177 0.40348 14.2857
78 1QGQ UDP 0.0002139 0.49629 16.4706
79 1OMZ UD2 0.007624 0.41722 23.2143
80 5LVP ATP 0.006993 0.43119 26.6667
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