Receptor
PDB id Resolution Class Description Source Keywords
2HYV 1.42 Å NON-ENZYME: OTHER HUMAN ANNEXIN A2 WITH HEPARIN HEXASACCHARIDE BOUND HOMO SAPIENS CALCIUM-BINDING PROTEIN MEMBRANE-BINDING PROTEIN HELIX BUNHEPARIN HEXASACCHARIDE METAL BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENT HEPA BINDING TO ANNEXIN A2. J.BIOL.CHEM. V. 281 31689 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:601;
A:602;
A:605;
A:607;
A:608;
 Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
none;
none;
 submit data
40.078 Ca [Ca+2...
IDS SGN IDS SGN UAP B:1;
 Valid;
 none;
 submit data
1385.05 n/a S(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HYV 1.42 Å NON-ENZYME: OTHER HUMAN ANNEXIN A2 WITH HEPARIN HEXASACCHARIDE BOUND HOMO SAPIENS CALCIUM-BINDING PROTEIN MEMBRANE-BINDING PROTEIN HELIX BUNHEPARIN HEXASACCHARIDE METAL BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENT HEPA BINDING TO ANNEXIN A2. J.BIOL.CHEM. V. 281 31689 2006
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 2HYU - SGN IDS SGN UAP n/a n/a
2 2HYV - IDS SGN IDS SGN UAP n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 6TWU Kd ~ 1 mM SER SER ARG THR ARG ARG GLU GLU GLN LEU n/a n/a
2 6TWX Kd ~ 2.5 mM SER SER ARG THR ARG ARG GLU TPO GLN LEU n/a n/a
3 2HYU - SGN IDS SGN UAP n/a n/a
4 2HYV - IDS SGN IDS SGN UAP n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 6TWU Kd ~ 1 mM SER SER ARG THR ARG ARG GLU GLU GLN LEU n/a n/a
2 6TWX Kd ~ 2.5 mM SER SER ARG THR ARG ARG GLU TPO GLN LEU n/a n/a
3 2HYU - SGN IDS SGN UAP n/a n/a
4 2HYV - IDS SGN IDS SGN UAP n/a n/a
5 1A8B - GPE C5 H14 N O6 P C(CO[P@](=....
6 1A8A - GSE C6 H14 N O8 P C([C@H](CO....
7 1G5N - SGN IDS SGN UAP n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: IDS SGN IDS SGN UAP; Similar ligands found: 13
No: Ligand ECFP6 Tc MDL keys Tc
1 IDS SGN IDS SGN UAP 1 1
2 SGN IDS SGN IDS SGN UAP 0.794643 0.969231
3 SGN IDS SGN UAP 0.794643 0.969231
4 SGN IDS SGN IDS 0.596639 0.938462
5 SGN IDS SGN IDS SGN 0.554688 0.939394
6 IDS SGN IDS SGN IDS 0.542636 0.924242
7 IDS SGN IDS SGN IDS SGN 0.526718 0.939394
8 IDS SGN IDS SGN IDS SUS IDS SGN 0.507463 0.953846
9 ZDO IDS SUS BDP SGN 0.5 0.925373
10 GNS UAP 0.470085 0.939394
11 IDY SGN 0.46281 0.910448
12 IDY SUS 0.430894 0.880597
13 BDP NPO GNS IDS GNS BDP GNS 0.412162 0.815789
Similar Ligands (3D)
Ligand no: 1; Ligand: IDS SGN IDS SGN UAP; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HYV; Ligand: IDS SGN IDS SGN UAP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2hyv.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
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