Receptor
PDB id Resolution Class Description Source Keywords
2HYV 1.42 Å NON-ENZYME: OTHER HUMAN ANNEXIN A2 WITH HEPARIN HEXASACCHARIDE BOUND HOMO SAPIENS CALCIUM-BINDING PROTEIN MEMBRANE-BINDING PROTEIN HELIX BUNHEPARIN HEXASACCHARIDE METAL BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENT HEPA BINDING TO ANNEXIN A2. J.BIOL.CHEM. V. 281 31689 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:601;
A:602;
A:605;
A:607;
A:608;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
UAP SGN IDS SGN IDS A:801;
Valid;
none;
submit data
1401.05 n/a [S+2]...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HYV 1.42 Å NON-ENZYME: OTHER HUMAN ANNEXIN A2 WITH HEPARIN HEXASACCHARIDE BOUND HOMO SAPIENS CALCIUM-BINDING PROTEIN MEMBRANE-BINDING PROTEIN HELIX BUNHEPARIN HEXASACCHARIDE METAL BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENT HEPA BINDING TO ANNEXIN A2. J.BIOL.CHEM. V. 281 31689 2006
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 2HYU - UAP SGN IDS SGN n/a n/a
2 2HYV - UAP SGN IDS SGN IDS n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 2HYU - UAP SGN IDS SGN n/a n/a
2 2HYV - UAP SGN IDS SGN IDS n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 2HYU - UAP SGN IDS SGN n/a n/a
2 2HYV - UAP SGN IDS SGN IDS n/a n/a
3 1A8B - GPE C5 H14 N O6 P C(CO[P@](=....
4 1A8A - GSE C6 H14 N O8 P C([C@H](CO....
5 1G5N - UAP SGN IDS SGN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: UAP SGN IDS SGN IDS; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 UAP SGN IDS SGN IDS 1 1
2 UAP SGN IDS SGN IDS SGN 0.839623 1
3 SGN IDS UAP SGN IDS SGN 0.839623 1
4 SGN IDS UAP SGN 0.839623 1
5 UAP SGN IDS SGN 0.839623 1
6 SGN IDS SGN IDS SGN IDS 0.733333 0.952381
7 IDS SGN IDS SGN IDS 0.681416 0.952381
8 IDS SGN IDS SGN IDS SUS IDS SGN 0.663793 0.952381
9 SGN IDS SGN IDS 0.596491 0.967742
10 IDS SGN IDS SGN IDS IDS 0.569106 0.9375
11 SGN IDS SGN IDS SGN 0.548387 0.9375
12 NGY BDP SGN IDS SGN BDP 0.492754 0.895522
13 SGN IDY 0.491071 0.876923
14 SUS IDY 0.444444 0.846154
15 GNS BDP GNS IDS GNS BDP NPO 0.428571 0.810811
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HYV; Ligand: UAP SGN IDS SGN IDS; Similar sites found: 58
This union binding pocket(no: 1) in the query (biounit: 2hyv.bio1) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5L53 NAP 0.006697 0.43756 1.2987
2 3IQE H4M 0.02737 0.40491 1.76678
3 1SNY NAP 0.007533 0.44194 1.87266
4 2Q1S NAI 0.03035 0.42534 1.94805
5 1I0Z NAI 0.02434 0.41795 1.94805
6 2JAH NDP 0.0302 0.41294 2.02429
7 1IY8 NAD 0.03878 0.40685 2.24719
8 2CFC NAD 0.01716 0.42451 2.4
9 2E5V FAD 0.03128 0.42461 2.5974
10 4PNE SAH 0.03546 0.40095 2.5974
11 1Z6Z NAP 0.01472 0.43011 2.83688
12 1FL2 FAD 0.04485 0.41228 3.24675
13 5J60 FAD 0.04929 0.41034 3.24675
14 1EDO NAP 0.02524 0.41798 3.27869
15 1G0N NDP 0.003741 0.47192 3.53357
16 1G0N PHH 0.01209 0.44486 3.53357
17 3SJ7 NDP 0.00401 0.45989 3.57143
18 4AGS GSH 0.01267 0.40176 3.57143
19 1UZN NAP 0.01311 0.41375 3.64372
20 2AG5 NAD 0.04023 0.4053 3.65854
21 2DTX BMA 0.03003 0.42087 3.78788
22 3LAD FAD 0.03818 0.41789 3.8961
23 5ITV NAI 0.04073 0.40614 4.31373
24 2B4Q NAP 0.02463 0.41736 4.34783
25 1U7Z PMT 0.01717 0.42884 4.42478
26 3GEG NAD 0.0148 0.42766 4.45344
27 4ITU 1HS 0.005679 0.46596 4.46097
28 4ITU NAI 0.003812 0.46596 4.46097
29 3AKK ADP 0.02152 0.40227 4.87013
30 3O26 NDP 0.0157 0.42854 5.19481
31 1ZBQ NAD 0.009272 0.44284 5.51948
32 1X1T NAD 0.0283 0.41698 6.15385
33 4CLI 5P8 0.02303 0.42854 6.16883
34 3OID NDP 0.02873 0.41603 6.20155
35 1A27 NAP 0.02778 0.41513 6.57439
36 4FN4 NAD 0.0042 0.45914 7.48031
37 4AT0 FAD 0.01741 0.44165 7.79221
38 2Z3Y F2N 0.04025 0.41686 7.79221
39 4PIV NDP 0.009394 0.44152 8.44156
40 2RH4 EMO 0.009405 0.45517 8.66426
41 1V59 FAD 0.03455 0.42265 8.76623
42 2GDZ NAD 0.01093 0.43582 8.98876
43 4CQM NAP 0.007243 0.4454 9.1954
44 4CNK FAD 0.04277 0.41528 9.41558
45 2BD0 NAP 0.001543 0.48598 9.42623
46 2WSB NAD 0.007947 0.45537 9.44882
47 1O6Z NAD 0.01138 0.4283 9.57096
48 1ZEM NAD 0.03554 0.40406 10.3053
49 3QWI CUE 0.004516 0.47032 10.3704
50 3QWI NAP 0.002977 0.47032 10.3704
51 1H5Q NAP 0.04369 0.40292 10.9434
52 3D3W NAP 0.004424 0.46134 12.2951
53 1AE1 NAP 0.04053 0.40807 12.4542
54 1XKQ NDP 0.04734 0.40425 12.5
55 2Q2V NAD 0.0183 0.42686 12.549
56 1E3W NAD 0.01871 0.42346 12.6437
57 1U7T NAD 0.02276 0.41635 12.6437
58 1U4J MAN 0.0001242 0.49033 12.7119
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