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Receptor
PDB id Resolution Class Description Source Keywords
2HYR 1.51 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A COMPLEX OF GRIFFITHSIN WITH MALTOSE GRIFFITHSIA GRIFFITHSIN LECTINS DOMAIN SWAPPING MANNOSE BINDING HIVSUGAR BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC, THERMODYNAMIC, AND MOLECULAR MODE STUDIES OF THE MODE OF BINDING OF OLIGOSACCHARIDES POTENT ANTIVIRAL PROTEIN GRIFFITHSIN. PROTEINS V. 67 661 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BGC GLC A:122;
A:124;
A:126;
B:122;
B:124;
B:126;
 Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
 none;
none;
none;
none;
none;
none;
 Kd = 394 uM
342.297 n/a O(CC1...
EDO A:601;
A:603;
B:602;
 Invalid;
Invalid;
Invalid;
 none;
none;
none;
 submit data
62.068 C2 H6 O2 C(CO)...
MG A:501;
A:502;
 Invalid;
Invalid;
 none;
none;
 submit data
24.305 Mg [Mg+2...
SO4 A:401;
A:402;
B:403;
 Invalid;
Invalid;
Invalid;
 none;
none;
none;
 submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HYR 1.51 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A COMPLEX OF GRIFFITHSIN WITH MALTOSE GRIFFITHSIA GRIFFITHSIN LECTINS DOMAIN SWAPPING MANNOSE BINDING HIVSUGAR BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC, THERMODYNAMIC, AND MOLECULAR MODE STUDIES OF THE MODE OF BINDING OF OLIGOSACCHARIDES POTENT ANTIVIRAL PROTEIN GRIFFITHSIN. PROTEINS V. 67 661 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 2HYR Kd = 394 uM BGC GLC n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 2HYR Kd = 394 uM BGC GLC n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 2HYR Kd = 394 uM BGC GLC n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: BGC GLC; Similar ligands found: 178
No: Ligand ECFP6 Tc MDL keys Tc
1 BGC GLA 1 1
2 GAL GLC 1 1
3 GLA BGC 1 1
4 BGC GLC 1 1
5 GLA GLC 1 1
6 LAK 1 1
7 GAL GAL 1 1
8 GLC BGC 1 1
9 MLB 1 1
10 MAN BMA 1 1
11 MAN MAN 1 1
12 BMA GLA 1 1
13 BMA MAN 1 1
14 GLC GLC 1 1
15 GLA BMA 1 1
16 BMA MAN MAN 0.953488 1
17 GLC GLC GLC GLC GLC BGC 0.953488 1
18 MAN MAN MAN 0.953488 1
19 GLC GLC GLC 0.953488 1
20 GLC GLC GLC GLC BGC 0.953488 1
21 AHR AHR 0.75 0.857143
22 FUB AHR 0.75 0.857143
23 MAN MAN MAN MAN 0.732143 1
24 MAN MAN BMA MAN 0.732143 1
25 AHR AHR AHR AHR AHR AHR 0.702128 0.857143
26 FUB AHR AHR 0.702128 0.857143
27 MAN BMA MAN 0.672727 1
28 MAN MMA 0.66 0.942857
29 GLC GLC GLC BGC 0.633333 1
30 M5S 0.606557 1
31 MAN BMA MAN MAN MAN 0.606557 1
32 MAN MAN MAN BMA MAN 0.575758 1
33 BMA BMA GLA BMA BMA 0.546875 1
34 MAN MMA MAN 0.540984 0.942857
35 MAN MAN MAN MAN MAN MAN MAN 0.535211 1
36 RAF 0.515625 0.891892
37 GIV 0.511628 0.848485
38 GLA 0.511628 0.848485
39 WOO 0.511628 0.848485
40 MAN 0.511628 0.848485
41 GAL 0.511628 0.848485
42 GLC 0.511628 0.848485
43 BGC 0.511628 0.848485
44 GXL 0.511628 0.848485
45 BMA 0.511628 0.848485
46 ALL 0.511628 0.848485
47 STW 0.507692 0.891892
48 MAN MAN MAN BMA MAN MAN MAN 0.5 0.942857
49 BMA MAN MAN MAN MAN 0.485294 1
50 NGB 0.485294 0.622642
51 4CQ 0.483871 0.970588
52 WZ2 0.477612 0.868421
53 LBT 0.472727 1
54 N9S 0.472727 1
55 CBI 0.472727 1
56 MAB 0.472727 1
57 LAT 0.472727 1
58 CBK 0.472727 1
59 B2G 0.472727 1
60 BGC BMA 0.472727 1
61 GLC GAL 0.472727 1
62 GLA GLA 0.472727 1
63 BMA GAL 0.472727 1
64 GLA GAL 0.472727 1
65 MAL 0.472727 1
66 GAL BGC 0.472727 1
67 BGC GAL 0.472727 1
68 NAG MAN MAN 0.472222 0.733333
69 RGG 0.471698 0.882353
70 SUC GLA 0.471429 0.891892
71 DMJ MAN 0.466667 0.695652
72 NOJ BGC 0.466667 0.695652
73 WZ3 0.463768 0.916667
74 DEG 0.462963 0.769231
75 IFM MAN 0.459016 0.711111
76 EMZ 0.458333 0.783784
77 M6P 0.45098 0.674419
78 G6P 0.45098 0.674419
79 BG6 0.45098 0.674419
80 M6D 0.45098 0.674419
81 A6P 0.45098 0.674419
82 BGP 0.45098 0.674419
83 AHR AHR AHR 0.45 0.805556
84 EBG 0.446429 0.837838
85 M3M 0.446429 1
86 LB2 0.446429 1
87 NGR 0.446429 1
88 EBQ 0.446429 0.789474
89 MAN GLC 0.446429 1
90 MT7 0.440678 1
91 MAN BMA BMA BMA BMA BMA 0.440678 1
92 DXI 0.440678 1
93 GLC GAL GAL 0.440678 1
94 BGC BGC BGC BGC 0.440678 1
95 GLC BGC BGC BGC BGC BGC 0.440678 1
96 GLC BGC GLC 0.440678 1
97 CEX 0.440678 1
98 GLC BGC BGC BGC BGC 0.440678 1
99 BGC GLC GLC GLC GLC GLC GLC 0.440678 1
100 MLR 0.440678 1
101 BGC BGC BGC BGC BGC 0.440678 1
102 CE5 0.440678 1
103 MAN BMA BMA BMA BMA 0.440678 1
104 BMA BMA BMA BMA BMA 0.440678 1
105 MTT 0.440678 1
106 MAN MAN BMA BMA BMA BMA 0.440678 1
107 GLC GLC GLC GLC GLC 0.440678 1
108 BGC GLC GLC 0.440678 1
109 BMA MAN BMA 0.440678 1
110 BGC GLC GLC GLC 0.440678 1
111 GLA GAL GLC 0.440678 1
112 CT3 0.440678 1
113 BGC BGC BGC 0.440678 1
114 BGC BGC GLC 0.440678 1
115 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.440678 1
116 CTR 0.440678 1
117 CEY 0.440678 1
118 GLC BGC BGC 0.440678 1
119 GLA GAL BGC 0.440678 1
120 BMA BMA BMA BMA BMA BMA 0.440678 1
121 GLC GLC BGC 0.440678 1
122 CTT 0.440678 1
123 BGC BGC BGC BGC BGC BGC 0.440678 1
124 BGC BGC BGC GLC 0.440678 1
125 MAN BMA BMA 0.440678 1
126 B4G 0.440678 1
127 GAL GAL GAL 0.440678 1
128 BGC GLC GLC GLC GLC 0.440678 1
129 CE8 0.440678 1
130 BMA BMA BMA 0.440678 1
131 GLC BGC BGC BGC 0.440678 1
132 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.440678 1
133 CE6 0.440678 1
134 ACY 1GN GAL 1GN BGC ACY GAL BGC 0.439024 0.6875
135 1GN ACY GAL ACY 1GN BGC GAL BGC 0.439024 0.6875
136 JZR 0.438596 0.714286
137 BHG 0.438596 0.714286
138 GLC HEX 0.438596 0.714286
139 TRE 0.4375 1
140 BMA Z4Y NAG 0.435897 0.717391
141 B7G 0.431034 0.738095
142 KGM 0.431034 0.738095
143 2M4 0.428571 1
144 MBG 0.428571 0.857143
145 MMA 0.428571 0.857143
146 GYP 0.428571 0.857143
147 AMG 0.428571 0.857143
148 GAL GAL SO4 0.424242 0.66
149 BOG 0.423729 0.738095
150 BNG 0.423729 0.738095
151 HSJ 0.423729 0.738095
152 M1P 0.423077 0.697674
153 XGP 0.423077 0.697674
154 G1P 0.423077 0.697674
155 GL1 0.423077 0.697674
156 BGC BGC XYS BGC 0.418919 0.942857
157 GAL FUC 0.416667 0.941176
158 SER MAN 0.416667 0.72093
159 XYT 0.415385 0.767442
160 BQZ 0.415094 0.909091
161 6SA 0.414894 0.733333
162 GAL BGC NAG GAL 0.413333 0.733333
163 GAL BGC BGC XYS 0.410959 0.942857
164 BGC BGC BGC GLC BGC BGC 0.409836 1
165 GLC BGC BGC BGC BGC BGC BGC 0.409836 1
166 GLA EGA 0.409836 0.942857
167 DGD 0.409639 0.733333
168 BMA NAG MAN MAN MAN MAN MAN MAN MAN 0.409091 0.733333
169 NAG NAG BMA MAN MAN 0.406977 0.6875
170 T6P 0.40678 0.767442
171 GLA GAL GAL 0.40625 1
172 IAB 0.404494 0.733333
173 MAN MAN BMA 0.403226 1
174 BMA BMA MAN 0.403226 1
175 GLC BGC BGC XYS BGC XYS XYS 0.402597 0.942857
176 BGC BGC BGC XYS BGC XYS XYS 0.402597 0.942857
177 BGC BGC XYS BGC XYS BGC XYS 0.402597 0.942857
178 BMA MAN MAN MAN 0.4 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HYR; Ligand: BGC GLC; Similar sites found with APoc: 285
This union binding pocket(no: 1) in the query (biounit: 2hyr.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1OFS SUC None
2 1LES GLC FRU None
3 2BQP GLC None
4 1WPY BTN None
5 2HMT NAI None
6 5Z2L NDP None
7 2DXU BT5 None
8 1N2X SAM None
9 4B5P ACO None
10 2B4B COA None
11 3P8N L4T 1.63934
12 2CVQ NDP 1.63934
13 2JE7 XMM 2.45902
14 1HYH NAD 2.45902
15 5BVA FAD 3.27869
16 5X9D 80F 3.27869
17 3CBG SAH 3.27869
18 1PZG A3D 3.27869
19 5O98 NAP 3.27869
20 3OU2 SAH 3.27869
21 4MO2 FDA 4.09836
22 4MO2 FAD 4.09836
23 5ZYN FAD 4.09836
24 16PK BIS 4.09836
25 3TKY SAH 4.09836
26 5BUK FAD 4.09836
27 6HOY AR6 4.09836
28 6HOY TSN 4.09836
29 1SOW NAD 4.09836
30 6AM8 TRP 4.09836
31 5MQ5 ASP 4.09836
32 5I3B HQE 4.09836
33 2W9S NDP 4.09836
34 3VPH OXM 4.19355
35 3VPH NAD 4.19355
36 3CW9 01A 4.91803
37 3NZK C90 4.91803
38 3AY6 NAI 4.91803
39 4O4F IHP 4.91803
40 4O4F ATP 4.91803
41 3P3G 3P3 4.91803
42 3P3G UKW 4.91803
43 4ZGS NAD 4.91803
44 1A5Z NAD 4.91803
45 2PUL ACP 4.91803
46 1ZEM NAD 4.91803
47 3KLJ FAD 4.91803
48 4GKY MAN 4.91803
49 5U8U FAD 4.91803
50 5VN0 NAI 4.91803
51 3B20 NAD 4.91803
52 4EMI FAD 4.91803
53 4FL3 ANP 4.91803
54 2XVF FAD 4.91803
55 2Q3R FMN 4.91803
56 2ZXI FAD 5.7377
57 6F97 FAD 5.7377
58 4O33 3PG 5.7377
59 4O33 TZN 5.7377
60 3STK PLM 5.7377
61 3C6K MTA 5.7377
62 3C6K SPD 5.7377
63 1VPE ANP 5.7377
64 4HKP TKW 5.7377
65 2XVE FAD 5.7377
66 3CGB FAD 5.7377
67 4U36 TNR 5.7377
68 3QV1 NAD 5.7377
69 4OOE NDP 5.7377
70 5GSN MMZ 5.7377
71 5GSN FAD 5.7377
72 5GSN NAP 5.7377
73 1RM4 NDP 5.7377
74 1QSM ACO 5.7377
75 4L77 CNL 5.7377
76 1RPN NDP 6.26866
77 5EYY MDM 6.55738
78 2GNM MAN 6.55738
79 2PHF MAN MAN BMA MAN 6.55738
80 2PHF MAN MAN 6.55738
81 3ZYR NAG NAG BMA MAN MAN NAG NAG 6.55738
82 2GN3 MAN 6.55738
83 3ZYR ASN NAG NAG BMA MAN MAN NAG NAG 6.55738
84 2GN3 MMA 6.55738
85 2GNB MAN 6.55738
86 2GMM MAN MAN 6.55738
87 1UKG MMA 6.55738
88 1Q8Q MAN MMA 6.55738
89 1LOF MAN BMA NAG NAG MAN NAG GAL GAL 6.55738
90 2PHU MAN MAN 6.55738
91 2GND MAN 6.55738
92 1Q8V MAN MAN 6.55738
93 1Q8O MAN MMA 6.55738
94 2PHT MAN MAN MAN 6.55738
95 1Q8V MAN MAN MAN 6.55738
96 2GND MAN MMA 6.55738
97 2PHW MAN MAN 6.55738
98 1Q8P MAN MMA 6.55738
99 2PHX MAN MAN MAN MAN 6.55738
100 2PHR MAN MAN 6.55738
101 2PHR MAN MAN BMA MAN 6.55738
102 2GMP NAG MAN 6.55738
103 2PHX MAN MAN 6.55738
104 1Q8S MAN MMA 6.55738
105 2PHU MAN MAN MAN BMA MAN 6.55738
106 2PHT MAN MAN MAN BMA MAN 6.55738
107 2PHW MAN MAN MAN BMA MAN MAN MAN 6.55738
108 1LOB MMA 6.55738
109 2AUY NAG MAN MMA 6.55738
110 5A1S FLC 6.55738
111 3NKS FAD 6.55738
112 5L4S 6KX 6.55738
113 5L4S NAP 6.55738
114 2AR6 NAG MAN 6.55738
115 1OFD FMN 6.55738
116 5YLT SFG 6.55738
117 1OFD AKG 6.55738
118 5NNA BZM 6.55738
119 2HJR APR 6.55738
120 2CUN 3PG 6.55738
121 6GAR FAD 6.55738
122 2BHZ MAL 6.55738
123 1WPQ NAD 6.55738
124 2AR6 NAG MAN MAN MAN NAG 6.55738
125 6FP4 FAD 6.55738
126 6FP4 E1T 6.55738
127 1N5D NDP 7.37705
128 4RPL FAD 7.37705
129 4RPL 3UC 7.37705
130 5OVK NDP 7.37705
131 4D42 W0I 7.37705
132 4D42 NAP 7.37705
133 1BXG NAD 7.37705
134 6A3J NAI 7.37705
135 6A3J SOE 7.37705
136 5OVL NAP 7.37705
137 5U3B 7TD 7.37705
138 1T3Q FAD 7.37705
139 1LVW TYD 7.37705
140 6GNC FAD 7.37705
141 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 7.37705
142 2JDR L20 7.37705
143 4UX9 ANP 7.37705
144 2D7I NGA 7.37705
145 4IXW IXW 7.37705
146 4M00 SUC 8.19672
147 5DEX 5E0 8.19672
148 5Z20 NAI 8.19672
149 1AE1 NAP 8.19672
150 4EXS X8Z 8.19672
151 3QWI CUE 8.19672
152 3QWI NAP 8.19672
153 1F76 FMN 8.19672
154 1RYI GOA 8.19672
155 1RYI FAD 8.19672
156 2ABJ CBC 8.19672
157 4AP3 NAP 9.01639
158 4AP3 FAD 9.01639
159 1YKF NAP 9.01639
160 1WMA NDP 9.01639
161 1WMA AB3 9.01639
162 5GM9 CBK 9.01639
163 2F5Z FAD 9.01639
164 5J5Z FAD 9.01639
165 2IVN ANP 9.01639
166 2JEV NHQ 9.01639
167 2PI8 NAG NAG NAG NAG NAG NAG 9.01639
168 1LDN NAD 9.01639
169 4POO SAM 9.01639
170 1Q9I FAD 9.01639
171 1Q9I TEO 9.01639
172 3D2M COA 9.01639
173 4PLG OXM 9.01639
174 4PLG NAI 9.01639
175 4PU6 ASP 9.01639
176 1KAO GDP 9.58084
177 5AB7 MLC 9.83607
178 1LYX PGA 9.83607
179 2UYT ADP 9.83607
180 2UYT LRH 9.83607
181 5F52 ASP 9.83607
182 1U6R ADP 9.83607
183 2Q6B HR2 9.83607
184 5JWC FAD 9.83607
185 3UCL NAP 9.83607
186 3UCL CYH 9.83607
187 3UCL FAD 9.83607
188 3AB1 FAD 9.83607
189 2YVJ FAD 10.0917
190 1B8U OAA 10.3343
191 1B8U NAD 10.3343
192 1MVQ MMA 10.6557
193 3GF4 UPG 10.6557
194 1VRP ADP 10.6557
195 4DQ2 BTX 10.6557
196 1D4D FAD 10.6557
197 6CEP OXM 10.6557
198 6CEP NAD 10.6557
199 3OEN GLU 10.6557
200 3GF4 FAD 10.6557
201 3B6R ADP 10.6557
202 1ZK4 NAP 10.6557
203 1ZK4 AC0 10.6557
204 1G55 SAH 10.6557
205 1PFK ADP 11.4754
206 5FFF NAP 11.4754
207 2NXW TPP 11.4754
208 2Q4W FAD 11.4754
209 4L8V NAP 11.4754
210 4IPE ANP 11.4754
211 2FLI DX5 11.4754
212 5GZ6 NDP 11.4754
213 5GZ6 7C3 11.4754
214 1MHW BP4 CYS DAR TYR PEA 11.9048
215 1KEV NDP 12.2951
216 5WGR FAD 12.2951
217 5X8G S0N 12.2951
218 1MO9 KPC 12.2951
219 1MO9 FAD 12.2951
220 3DUW SAH 12.2951
221 2Q1W NAD 12.2951
222 1BW9 NAD 13.1148
223 1EQ2 NAP 13.1148
224 1C1X NAD 13.1148
225 1EZ4 NAD 13.1148
226 3RNM FAD 13.7931
227 4C3Y FAD 13.9344
228 4PLT NAI 13.9344
229 4BG4 ADP 13.9344
230 4C3Y ANB 13.9344
231 1GUA GNP 13.9344
232 4PLT OXM 13.9344
233 5ERG SAM 13.9344
234 1LTH NAD 13.9344
235 6FDF SAH 13.9344
236 3NRZ FAD 13.9344
237 3JQ8 NAP 13.9344
238 1M15 ADP 14.7541
239 1M15 ARG 14.7541
240 2Q7V FAD 14.7541
241 5GLN XYS 14.7541
242 1TZJ A3B 14.7541
243 5NMX NAP 15.5738
244 5NMX FAD 15.5738
245 3HDY FDA 15.5738
246 3HDY FAD 15.5738
247 1GQG DCD 15.5738
248 3O26 NDP 17.2131
249 1FL2 FAD 17.2131
250 3JQ3 ADP 17.2131
251 1KGQ NPI 17.2131
252 1KGQ SCO 17.2131
253 1RP7 TZD 17.2131
254 3AXK NDP 18.0328
255 6ER9 NAP 18.0328
256 2JK0 ASP 18.0328
257 2X6T NAP 18.8525
258 5V6F MAN BMA MAN 19.6721
259 4YRY FAD 19.6721
260 1FNZ A2G 19.6721
261 3PT9 SAH 19.6721
262 2FMD MAN MAN 20.4918
263 1ELI PYC 21.3115
264 6GAS FAD 21.3115
265 3ENG CBI 22.1311
266 1XXR MAN 23.7705
267 1VBO MAN 24.5902
268 1VBO MAN MAN MAN 24.5902
269 1JOT GAL A2G 24.5902
270 6CGD AKN 24.5902
271 6CGD GNP 24.5902
272 1C3M MAN MAN 34.4262
273 1WS5 MMA 37.7049
274 1WS4 AMG 37.7049
275 1WS4 GYP 37.7049
276 1UGY GLA BGC 37.7049
277 1KUJ MMA 37.7049
278 1UGY GLA GLC 37.7049
279 1UGW GAL 37.7049
280 1M26 GAL A2G 37.7049
281 1JAC AMG 37.7049
282 1UGX GAL MGC 37.7049
283 1TOQ AMG 40.1639
284 6FLZ MMA 45.082
285 2BMZ XLM 48.3607
Pocket No.: 2; Query (leader) PDB : 2HYR; Ligand: BGC GLC; Similar sites found with APoc: 138
This union binding pocket(no: 2) in the query (biounit: 2hyr.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 3WDM ADN None
2 5ZBL AMP None
3 3O61 GDD None
4 3BGD SAH None
5 3BGD PM6 None
6 4O4K 2PK None
7 2HNK SAH 0.83682
8 1O0S NAI 1.63934
9 2JAP NDP 1.63934
10 2O4C NAD 2.45902
11 3RFV 15L 2.45902
12 3RFV NAI 2.45902
13 2ZC0 PMP 2.45902
14 5I39 FAD 3.27869
15 4JWF SAH 3.27869
16 4JWH SAH 3.27869
17 1PN0 FAD 3.27869
18 1PN0 IPH 3.27869
19 2I7C AAT 3.27869
20 2PT9 2MH 3.27869
21 2PT9 S4M 3.27869
22 4MIG G3F 3.27869
23 3RG9 NDP 3.27869
24 6GKV SAH 4.09836
25 2I0K FAD 4.09836
26 1Z82 NDP 4.09836
27 1YKJ FAD 4.09836
28 1YKJ PHB 4.09836
29 1XDS SAM 4.09836
30 1QO8 FAD 4.91803
31 4GN8 ASO 4.91803
32 4HA6 FAD 4.91803
33 4EMI NAD 4.91803
34 5EEH P9P 4.91803
35 5EEH SAH 4.91803
36 1M7Y PPG 4.91803
37 5E1M PRO PRO LYS ARG ILE ALA 4.91803
38 5E1M SAH 4.91803
39 5YJF 8WO 4.91803
40 5YJF SAH 4.91803
41 2HQM FAD 5.7377
42 4HA9 NDP 5.7377
43 1UXG FUM 5.7377
44 1UXG NAD 5.7377
45 1ZGA SAH 5.7377
46 2O3Z AI7 5.7377
47 5ICE SAH 5.7377
48 5ICE 2H4 5.7377
49 5YJI 8WO 5.7377
50 5YJI SAH 5.7377
51 5ZBC FAD 5.7377
52 2D3N GLC GLC GLC 5.7377
53 2F5T MAL 5.7377
54 4OOE FOM 5.7377
55 3AB4 THR 5.7377
56 4MO4 ACP 5.7377
57 4EI7 GDP 5.7377
58 1GUZ NAD 6.55738
59 1FP1 SAH 6.55738
60 5NUF NAD 6.55738
61 1GV0 NAD 6.55738
62 5NUE NAD 6.55738
63 3T7S SAM 6.55738
64 1YQS BSA 6.55738
65 3AAQ ARU 6.55738
66 4O0L NDP 6.55738
67 2YVF FAD 6.55738
68 2R4J FAD 6.55738
69 2R4J 13P 6.55738
70 2RGO FAD 7.37705
71 2C5A GDC 7.37705
72 2C5A NAD 7.37705
73 5J60 FAD 7.37705
74 5EOW FAD 7.37705
75 4JDR FAD 7.37705
76 2VD9 EPC 7.37705
77 2VD9 IN5 7.37705
78 1F8G NAD 7.37705
79 2R5C C6P 7.37705
80 4KQ6 DLZ 7.37705
81 5JY6 NAD 7.37705
82 1E3W NAD 7.37705
83 4MDH NAD 8.19672
84 5MDH NAD 8.19672
85 5ZZ6 ADP 8.19672
86 5BRT CH9 8.19672
87 5BRT FAD 8.19672
88 6C4M NAP 8.19672
89 4E70 N7I 8.19672
90 4M52 FAD 8.19672
91 2GCG NDP 8.19672
92 6AA8 NAD 9.01639
93 3OVR 5SP 9.01639
94 5TUK FAD 9.01639
95 5THQ NDP 9.83607
96 1JQD HSM 9.83607
97 1JQD SAH 9.83607
98 4A6D SAM 9.83607
99 9LDT NAD 9.83607
100 9LDB NAD 9.83607
101 1VGR COA 9.83607
102 1NVM NAD 9.83607
103 2DFV NAD 9.83607
104 1XI9 PLP 9.83607
105 5X20 NAD 9.83607
106 2YVJ NAI 10.0917
107 5OE4 3UK 10.6557
108 5ZAI COA 10.6557
109 6FA4 GNP 10.9827
110 1NAA 6FA 11.4754
111 1NAA ABL 11.4754
112 4Z24 FAD 11.4754
113 3GFB NAD 12.2951
114 5LOG SAH 12.2951
115 2RAB NAD 12.2951
116 1C7R PA5 12.2951
117 1KYZ SAH 13.1148
118 3CB2 GDP 13.1148
119 2GAG FAD 13.1148
120 1KYZ FER 13.1148
121 3QMN COA 13.1148
122 1LVL FAD 13.1148
123 4HDO GNP 13.1148
124 5FJN BE2 13.9344
125 4AT0 FAD 13.9344
126 5ODQ FAD 13.9344
127 5FJN FAD 13.9344
128 5WPJ NDP 13.9344
129 1TUF AZ1 13.9344
130 3WGT QSC 14.7541
131 3WGT FAD 14.7541
132 5TS5 FAD 15.5738
133 2QA1 FAD 16.3934
134 1FP2 SAH 16.3934
135 4BV6 FAD 18.8525
136 3ZEI AWH 19.6721
137 3CTY FAD 21.3115
138 1PJS NAD 21.3115
Pocket No.: 3; Query (leader) PDB : 2HYR; Ligand: BGC GLC; Similar sites found with APoc: 55
This union binding pocket(no: 3) in the query (biounit: 2hyr.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 2GJ5 VD3 None
2 4WOP CTP None
3 4RFM 3P6 None
4 5N81 8Q2 2.45902
5 1VFS DCS 4.09836
6 2A8X FAD 4.09836
7 4TW7 37K 4.09836
8 4X6I 3Y1 4.09836
9 3GDN FAD 4.91803
10 2B1N LYS ALA SER VAL GLY 4.91803
11 1H6C NDP 4.91803
12 1H6C SIN 4.91803
13 5OOH 9ZZ 4.91803
14 5OOH NAP 4.91803
15 3H8C NSZ 5
16 2PWY SAH 5.7377
17 2D3S TNR 6.55738
18 3F8D FAD 6.55738
19 2OFD NGA 7.04225
20 5WS9 AMP 7.37705
21 3AI8 HNQ 7.37705
22 2VPQ ANP 8.19672
23 2YY7 NAD 8.19672
24 4MRT COA 8.19672
25 2VBU CDP 8.19672
26 2WPU KYT 8.19672
27 2Y6Q I7T 9.01639
28 2Y6Q FAD 9.01639
29 2A92 NAI 9.01639
30 1NLU IVA PHI TYB 9.01639
31 1MDZ DCS 9.01639
32 1MDZ PLP 9.01639
33 3Q9T FAY 9.83607
34 3GMB FAD 9.83607
35 4K81 GTP 9.83607
36 3PFD FDA 9.83607
37 1O94 ADP 10.6557
38 6D59 GNP 11.3772
39 6DIO NAD 11.4754
40 2Z6J FMN 11.4754
41 2VQD AP2 13.1148
42 1FIQ FAD 13.9344
43 2VZ0 NAP 13.9344
44 2VZ0 D64 13.9344
45 4CM9 NAP 13.9344
46 1N62 FAD 14.7541
47 4EKV BTN 14.7541
48 5L3S GNP 15.5738
49 3AXB PRO 15.5738
50 5OC1 FAD 17.2131
51 3QDV A2G 21.3115
52 3QDW A2G 21.3115
53 4J56 FAD 24.5902
54 1KPG SAH 26.2295
55 5Z75 NAD 37.7049
Pocket No.: 4; Query (leader) PDB : 2HYR; Ligand: BGC GLC; Similar sites found with APoc: 49
This union binding pocket(no: 4) in the query (biounit: 2hyr.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 4IGH FMN 1.63934
2 4IGH ORO 1.63934
3 4IGH 1EA 1.63934
4 4YNU FAD 4.09836
5 1T5B FMN 4.09836
6 2JB2 FAD 4.91803
7 3GDN HBX 4.91803
8 3LST SAH 4.91803
9 3ICR FAD 4.91803
10 1SB8 UD2 4.91803
11 1SB8 NAD 4.91803
12 3ICS FAD 4.91803
13 4KWI 1TJ 4.91803
14 4J7U NAP 4.91803
15 4J7U YTZ 4.91803
16 3L4S NAD 4.91803
17 2AE2 PTO 5.7377
18 2AE2 NAP 5.7377
19 1OAA OAA 5.7377
20 1TUU ADP 5.7377
21 4A59 AMP 6.55738
22 1V59 FAD 6.55738
23 5LD5 NAD 6.55738
24 4J36 FAD 6.98795
25 2GOU FMN 7.37705
26 3LAD FAD 7.37705
27 1RVV INI 7.37705
28 3LU1 NAD 7.37705
29 4M52 M52 8.19672
30 1GPM CIT 8.19672
31 2XYQ SAH 9.01639
32 1YQZ FAD 9.83607
33 4CQM NAP 9.83607
34 2AOT SAH 9.83607
35 1QZZ SAM 10.6557
36 3P9C SAH 11.4754
37 3I53 SAH 11.4754
38 4Z0H NAD 11.4754
39 3T31 DCQ 12.2951
40 3T31 FAD 12.2951
41 3EWP APR 13.1148
42 2BFR ADP 13.9344
43 1U7T NAD 13.9344
44 5GLN XYP XYP XYP 14.7541
45 4MOP 2H5 15.5738
46 3AXB FAD 15.5738
47 3SSO SAH 18.0328
48 6GNA FAD 21.3115
49 5HSA FAS 23.7705
Pocket No.: 5; Query (leader) PDB : 2HYR; Ligand: BGC GLC; Similar sites found with APoc: 59
This union binding pocket(no: 5) in the query (biounit: 2hyr.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 3GD4 FAD 2.45902
2 1O8B ABF 3.27869
3 4I42 1HA 3.27869
4 5JIC ADP 3.27869
5 5JIC N7E 3.27869
6 3ITJ FAD 4.09836
7 4U8P FDA 4.09836
8 4U8P UDP 4.09836
9 5TTJ FAD 4.09836
10 2JB2 PHE 4.91803
11 4K5S PM0 4.91803
12 4K5S FAD 4.91803
13 3RS8 APR 4.91803
14 2BNE U5P 4.91803
15 5TWB FAD 5.7377
16 6C2Z P1T 5.7377
17 1XSE NDP 5.7377
18 2YYY NAP 5.7377
19 6F7L FAD 6.55738
20 2CUL FAD 6.55738
21 1L3I SAH 6.55738
22 3X0V FAD 6.55738
23 1GPE FAD 6.55738
24 4CJX NAP 6.55738
25 5K4G ASP 6.55738
26 6CI9 NAP 7.37705
27 5I60 67W 7.37705
28 2OOR NAD 7.37705
29 3UZO GLU 8.19672
30 5KOX FAD 9.01639
31 5KOX RFP 9.01639
32 1M5B BN1 9.01639
33 6N35 MAN MAN 9.83607
34 1V97 MTE 9.83607
35 4O9S 2RY 9.83607
36 2WLT ASP 9.83607
37 1NYT NAP 9.83607
38 4RF2 NAP 10.6557
39 1D09 PAL 10.6557
40 4XQC 13D 10.6557
41 4XQC NAD 10.6557
42 2IVD FAD 11.4754
43 5BSR AMP 11.4754
44 5BSR COA 11.4754
45 3I54 CMP 11.4754
46 3I59 N6R 11.4754
47 2RAB FAD 12.2951
48 5FOI MY8 12.2951
49 2HIM ASN 12.2951
50 2HIM ASP 12.2951
51 5XWV 8H6 12.2951
52 5XWV NDP 12.2951
53 5X68 FAD 13.1148
54 4OM8 NAD 13.1148
55 5DNC ASN 13.9344
56 4R8L ASP 13.9344
57 1ZC3 GNP 13.9344
58 1IYE PGU 18.0328
59 4UP3 FAD 27.0492
Pocket No.: 6; Query (leader) PDB : 2HYR; Ligand: BGC GLC; Similar sites found with APoc: 49
This union binding pocket(no: 6) in the query (biounit: 2hyr.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 3CH6 NAP 1.63934
2 3CH6 311 1.63934
3 3GD4 NAD 2.45902
4 2QV7 ADP 3.27869
5 5YU3 NAD 4.09836
6 5YU3 PRO 4.09836
7 6FFI D8B 4.09836
8 4KWI NAP 4.91803
9 3K56 IS3 4.91803
10 3EYA FAD 4.91803
11 4ZCC FAD 4.91803
12 3ICS ADP 4.91803
13 3EYA TDP 4.91803
14 4RSL FAD 4.91803
15 3L4S 3PG 4.91803
16 2E5V FAD 6.55738
17 3S5W FAD 6.55738
18 3PC3 P1T 6.55738
19 2B4R AES 7.37705
20 2B4R NAD 7.37705
21 1UPA TPP 7.37705
22 5B47 TPP 8.19672
23 5B47 PYR 8.19672
24 5ZZ6 NAD 8.19672
25 3CQD ATP 8.19672
26 3E1T FAD 9.01639
27 4IV9 FAD 9.01639
28 1GKZ ADP 9.01639
29 4X9M FAD 9.83607
30 1LDM NAD 9.83607
31 5OCM NAP 9.83607
32 1FFU FAD 9.83607
33 2CSN CKI 10.6557
34 2ZUX RAM 10.6557
35 5FFF 5XC 11.4754
36 3LZW FAD 12.2951
37 2UZ1 TPP 12.2951
38 3IAE D7K 12.2951
39 1E6E FAD 13.1148
40 2GAG NAD 13.1148
41 1DQX BMP 13.9344
42 3MB5 SAM 14.7541
43 2RCU BUJ 14.7541
44 1FP2 HMO 16.3934
45 6ER9 FAD 18.0328
46 1C0I BE2 19.6721
47 1C0I FAD 19.6721
48 4KP7 NAP 28.6885
49 4KP7 1UQ 28.6885
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