Receptor
PDB id Resolution Class Description Source Keywords
2HY0 1.7 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 22 HOMO SAPIENS CHEK1 KINASE CELL CYCLE CHECKPOINT TRANSFERASE
Ref.: DEVELOPMENT OF 6-SUBSTITUTED INDOLYLQUINOLINONES AS POTENT CHEK1 KINASE INHIBITORS. BIOORG.MED.CHEM.LETT. V. 16 5907 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
306 A:324;
Valid;
none;
ic50 = 0.65 nM
423.51 C26 H25 N5 O c1cc2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HY0 1.7 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 22 HOMO SAPIENS CHEK1 KINASE CELL CYCLE CHECKPOINT TRANSFERASE
Ref.: DEVELOPMENT OF 6-SUBSTITUTED INDOLYLQUINOLINONES AS POTENT CHEK1 KINASE INHIBITORS. BIOORG.MED.CHEM.LETT. V. 16 5907 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 107 families.
1 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
70% Homology Family (67)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 82 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
3 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
4 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
5 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
6 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
7 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
8 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
9 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
10 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
11 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
12 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
13 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
14 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
15 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
16 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
17 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
18 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
19 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
20 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
21 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
22 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
23 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
24 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
25 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
26 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
27 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
28 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
29 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
30 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
31 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
32 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
33 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
34 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
35 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
36 5F4N ic50 = 2.2 nM 5UY C17 H19 N7 O3 COC(=O)c1c....
37 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
38 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
39 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
40 3NLB ic50 = 35 nM 5BE C21 H28 N6 O Cc1c(c([nH....
41 3JVR Ki = 1.89 uM AGX C16 H13 Cl2 N3 O2 C[C@@H](c1....
42 2WMX ic50 = 0.86 uM ZY6 C17 H19 N5 O c1ccc(cc1)....
43 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
44 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
45 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
46 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
47 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
48 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
49 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
50 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
51 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
52 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
53 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
54 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
55 3JVS Ki = 0.146 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
56 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
57 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
58 2C3L Ki = 0.026 uM IDZ C14 H10 N4 c1ccc2c(c1....
59 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
60 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
61 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
62 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
63 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 C[C@@]12[C....
64 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
65 4RVK ic50 = 13.5 nM 3XK C19 H13 N5 O CC(=O)Nc1c....
66 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
67 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
50% Homology Family (29)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
3 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
4 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
5 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
6 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
7 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
8 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
9 3NLB ic50 = 35 nM 5BE C21 H28 N6 O Cc1c(c([nH....
10 3JVR Ki = 1.89 uM AGX C16 H13 Cl2 N3 O2 C[C@@H](c1....
11 2WMX ic50 = 0.86 uM ZY6 C17 H19 N5 O c1ccc(cc1)....
12 1SZM ic50 = 6.35 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
13 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
14 5LVO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
15 4XX9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
16 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
17 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
18 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
19 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
20 3QCQ ic50 = 0.00000001 M 3Q0 C13 H15 N7 CCNc1cc(nc....
21 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
22 2UW9 - GVP C20 H20 Cl N3 c1cc(ccc1c....
23 2JDR ic50 = 0.5 nM L20 C24 H23 N5 O Cc1c2cc(cc....
24 3UBD Kd = 2.9 uM SL0 C25 H24 O12 CC1C(C(C(C....
25 4GUE Kd = 5.8 uM QCT C21 H20 O11 C[C@H]1[C@....
26 3G51 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
27 3QKK - SMH C28 H38 N2 O7 S CCOCCN(C[C....
28 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 C[C@@H]1C[....
29 3WF5 ic50 = 81 nM FZ8 C17 H17 N7 c1ccc2c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 306; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 306 1 1
2 373 0.52381 0.866667
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HY0; Ligand: 306; Similar sites found: 280
This union binding pocket(no: 1) in the query (biounit: 2hy0.bio1) has 17 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4O4F ATP 0.004195 0.4344 1.20968
2 4O4F IHP 0.004518 0.4344 1.20968
3 5W2I ADP 0.0008531 0.46602 1.55642
4 5W2I I3P 0.0008531 0.46602 1.55642
5 3X01 AMP 0.0002048 0.50006 1.86335
6 2IF8 ADP 0.000555 0.43808 1.86335
7 5COU ATP 0.002344 0.43318 1.86335
8 3VOT ADP 0.002507 0.42229 1.86335
9 1I7L ATP 0.001374 0.45607 1.94175
10 3VPC ADP 0.001333 0.40213 2.12766
11 2PUL ACP 0.01915 0.4167 2.17391
12 1EHI ADP 0.01069 0.4064 2.17391
13 3KA2 2NC 0.04937 0.40455 2.17391
14 1PK8 ATP 0.00165 0.45397 2.48447
15 2V58 LZJ 0.004884 0.45183 2.48447
16 3W0O HY0 0.006972 0.42947 2.48447
17 3W0O ADP 0.006972 0.42947 2.48447
18 1NZY BCA 0.01288 0.41501 2.60223
19 1JXZ BCA 0.01407 0.41313 2.60223
20 4ZS4 ATP 0.0001493 0.49369 2.60586
21 4OCJ NDG 0.01867 0.41625 2.79503
22 4XYM A12 0.008195 0.41185 2.79503
23 2Q7D ANP 0.01742 0.40586 2.79503
24 3PDT ADP 0.000516 0.46119 2.90909
25 5K2M ADP 0.003308 0.43774 2.9304
26 3DGY 2GP 0.002609 0.4449 3.09278
27 2VPQ ANP 0.001048 0.45989 3.10559
28 4OCV ANP 0.004651 0.42345 3.10559
29 3SJK LYS PRO VAL LEU ARG THR ALA 0.01741 0.40653 3.15789
30 1IA9 ANP 0.000418 0.43235 3.21429
31 4CYI ATP 0.000007563 0.55724 3.41615
32 3TII ANP 0.001778 0.4285 3.41615
33 4R78 AMP 0.003135 0.41686 3.41615
34 1ZTH ADP 0.00001609 0.5178 3.48837
35 1ZP9 ATP 0.00005543 0.50587 3.48837
36 1TZD ADP 0.0002692 0.41318 3.63636
37 1W2D 4IP 0.004064 0.43959 3.77358
38 1W2D ADP 0.001015 0.43959 3.77358
39 5C1P ADP 0.002692 0.42565 3.92157
40 5C1P DAL DAL 0.007352 0.42261 3.92157
41 3I0O ADP 0.002791 0.41962 4.03727
42 5XDT ZI7 0.01757 0.40706 4.22078
43 2PYW ADP 0.00002882 0.52977 4.34783
44 2VQD AP2 0.002099 0.44172 4.34783
45 1M0W ANP 0.0057 0.41303 4.34783
46 2Q4W FAD 0.02274 0.40983 4.65839
47 1N62 FAD 0.02345 0.41317 4.81928
48 5MW8 ATP 0.0002174 0.49254 4.96894
49 5NCY 8TK 0.007016 0.42933 4.96894
50 2QK4 ATP 0.0015 0.42673 4.96894
51 3ETH ATP 0.008715 0.41419 4.96894
52 4AUT FAD 0.02765 0.4095 4.96894
53 3WLE NAD 0.03665 0.40133 4.96894
54 3HAV ATP 0.00193 0.40348 5.01672
55 5I35 ANP 0.0004283 0.46746 5.2795
56 3DNT ATP 0.006086 0.425 5.2795
57 3ILR SGN IXD 0.03511 0.4124 5.2795
58 1TQP ATP 0.0006179 0.47274 5.31915
59 4U98 ACP 0.005139 0.41732 5.50661
60 3TDV GDP 0.0008786 0.4553 5.55556
61 1OBD ATP 0.006551 0.40793 5.55556
62 4GYI ADP 0.0006479 0.454 5.59006
63 3KAL ADP 0.007527 0.43163 5.59006
64 2IO8 ADP 0.0006955 0.47028 6.21118
65 1T36 ADP 0.008255 0.42312 6.21118
66 4ANW O92 0.001464 0.46562 6.8323
67 2FB3 GTP 0.01574 0.41203 6.8323
68 5VZ0 ADP 0.0005708 0.46167 7.14286
69 4MV1 ADP 0.004429 0.44182 7.14286
70 5DZT AMP 0.001198 0.41775 7.45342
71 2BKK ADP 0.009745 0.4 7.57576
72 1T3Q FAD 0.0115 0.42795 7.7381
73 3UDZ ADP 0.0001615 0.49209 7.76398
74 1NY5 ADP 0.001433 0.44537 7.76398
75 4WN5 MVC 0.01537 0.40241 7.82609
76 2GQS ADP 0.002997 0.42821 8.01688
77 2GQR ADP 0.006791 0.41168 8.01688
78 3WVR AMP 0.001682 0.43752 8.38509
79 4IX4 ADP 0.0006308 0.46642 9.00621
80 5LXT ACP 0.00807 0.41747 9.09091
81 5IQD GNP 0.001261 0.47405 9.18033
82 5IQD RIO 0.001333 0.47405 9.18033
83 3ORQ ADP 0.007827 0.41464 9.31677
84 5FI4 5XV 0.007182 0.42154 10.2484
85 5DXT 5H5 0.005274 0.42088 10.2484
86 4FFG 0U8 0.01857 0.4043 10.559
87 4AZW ATP 0.007275 0.41615 10.8696
88 4AZT LY2 0.004438 0.41159 10.8696
89 5CKW ANP 0.0003596 0.45892 11.4907
90 4WW7 AMP 0.00008816 0.50909 11.4943
91 4DFU QUE 0.007837 0.41789 14.2857
92 5C4L 4XR 0.008629 0.4262 14.3302
93 4OAV ACP 0.0000007172 0.59635 14.5963
94 3VHE 42Q 0.00000004224 0.68549 15.2174
95 3VPB ADP 0.0006937 0.47213 16.0714
96 3HRD FAD 0.03099 0.40966 16.25
97 2AQX ATP 0.007588 0.41706 16.263
98 5MY8 RXZ 0.000002038 0.59426 17.2324
99 4O1P ANP 0.000001418 0.58576 18.0124
100 4Q5H ANP 0.001583 0.44334 18.9655
101 5GZ9 ANP 0.000001938 0.59046 19.0164
102 3P7G MAN 0.01026 0.41326 19.863
103 3KMW ATP 0.0002128 0.48157 26.9373
104 1OPK P16 0.00000006576 0.67832 27.6398
105 4FL3 ANP 0.00000009507 0.65011 28.2609
106 5HCY 60D 0.0000002223 0.67232 28.5714
107 3PP0 03Q 0.0000006492 0.48151 28.5714
108 2H8H H8H 0.00000002284 0.66952 28.882
109 4WHZ 3NL 0.000002595 0.62334 28.882
110 1Y57 MPZ 0.0000009272 0.60575 28.882
111 3PTG 932 0.000001055 0.5609 28.882
112 5C03 AGS 0.0002112 0.48423 28.882
113 3TTI KBI 0.00001909 0.43404 28.882
114 3EKK GS2 0.00000002733 0.70775 28.9902
115 3BU5 ATP 0.0000001349 0.63348 29.085
116 5EOB 5QQ 0.000007484 0.60555 29.1536
117 3H9R TAK 0.0000000006391 0.697 29.1925
118 4CRL C1I 0.0000008065 0.62864 29.1925
119 3C1X CKK 0.000005783 0.56532 29.1925
120 3UIM ANP 0.00001001 0.5461 29.1925
121 4IZY 1J2 0.000008176 0.49103 29.1925
122 4WOV 3SM 0.000007816 0.54184 29.3375
123 2XVD AS6 0.0000001593 0.65494 29.4702
124 4ASE AV9 0.00000002595 0.69094 29.5031
125 1OUK 084 0.0001238 0.57057 29.5031
126 4XH0 ADP 0.00001008 0.56599 29.5031
127 4UX9 ANP 0.0000004368 0.52882 29.5031
128 1U5R ATP 0.001144 0.47859 29.5031
129 5U6C 7YS 0.0000002947 0.62676 29.5238
130 3PLS ANP 0.000003659 0.56349 29.5302
131 3NW7 LGV 0.000001978 0.62673 29.6417
132 4AG8 AXI 0.00000002264 0.46032 29.7468
133 3KRL KRL 0.0000000001098 0.7897 29.8137
134 3E7O 35F 0.0000001103 0.66941 29.8137
135 5AWM ANP 0.000002884 0.55109 29.8137
136 3E8N VRA 0.005798 0.47613 29.8137
137 3E8N ATP 0.005798 0.47613 29.8137
138 4BKJ STI 0.0002302 0.49524 29.8413
139 3LXN MI1 0.00000006381 0.65526 29.8742
140 3LXK MI1 0.00000001439 0.7034 30.1242
141 4P5Z Q7M 0.0000002472 0.66164 30.1242
142 5NKB 8ZT 0.00000007994 0.42928 30.3922
143 2B9H ADP 0.000001065 0.5946 30.4348
144 2B9J ADP 0.000001624 0.57987 30.4348
145 2B9F ADP 0.00000201 0.57867 30.4348
146 1K3A ACP 0.000006901 0.54432 30.4348
147 2B9I ADP 0.000001283 0.53918 30.4348
148 5T8O 76Z 0.000002871 0.50493 30.4348
149 3VRY B43 0.0000006981 0.49047 30.4348
150 2OO8 RAJ 0.0001027 0.50594 30.5994
151 4IDT T28 0.0000000611 0.646 30.7453
152 4BTK DTQ 0.0001049 0.49843 30.7453
153 3GC8 B45 0.00001686 0.46527 30.7453
154 2X2M X2M 0.0000000005693 0.75574 30.8917
155 4XLI 1N1 0.000000005931 0.69303 30.9701
156 4LOO SB4 0.0003374 0.47472 31.0345
157 5LPZ ADP 0.00000136 0.5866 31.0559
158 3GC0 AMP 0.000001237 0.5785 31.0559
159 4FF8 14S 0.001291 0.43465 31.0559
160 3RI1 3RH 0.000000005211 0.72213 31.3099
161 4Y93 746 0.00000002924 0.68316 31.3665
162 2PVF ACP 0.0000000732 0.64236 31.3665
163 4GJ3 0XP 0.00000003869 0.68967 31.457
164 2WU6 DKI 0.00000002881 0.67778 31.677
165 5UKL SIX 0.000001939 0.59978 31.677
166 3GQI ACP 0.00000103 0.59224 31.677
167 3GNI ATP 0.000007635 0.55704 31.677
168 3PVW QRX 0.00000005059 0.51038 31.677
169 4TWP AXI 0.00000000866 0.74593 31.7343
170 2Y6O 1N1 0.00000004156 0.66718 31.9588
171 3HMO STU 0.00000007001 0.64326 31.9876
172 4K33 ACP 0.0000001029 0.6423 31.9876
173 4KBA 1QM 0.00001624 0.44014 31.9876
174 5JGA 6KC 0.00000000221 0.75335 32.0635
175 5HX8 66P 0.000000001307 0.75123 32.1192
176 5USZ SKE 0.000000569 0.6257 32.1799
177 5EFQ ADP 0.00001188 0.54263 32.2981
178 5JKG 6LF 0.0000000202 0.7163 32.4759
179 5N87 N66 0.00000004687 0.69405 32.5879
180 4WNK 453 0.0000001378 0.6603 32.6087
181 5EKO N17 0.00003755 0.52897 32.6087
182 3G5D 1N1 0.00000006525 0.71421 32.8671
183 5X8I SQZ 0.00000005277 0.65253 32.9193
184 4YLL 4E3 0.000006833 0.56432 32.9193
185 4E1Z 0MX 0.00000004093 0.67049 32.9897
186 4CLI 5P8 0.00000001089 0.7391 33.0275
187 5MJA 7O3 0.00000004418 0.64876 33.1148
188 5KO1 6UY 0.000001388 0.58304 33.2155
189 5UR1 YY9 0.000000005036 0.75437 33.4405
190 1U59 STU 0.0000000003202 0.7561 33.4495
191 5LXC 7AA 0.00000009291 0.63387 33.5404
192 5HES 032 0.00000001268 0.69168 33.5505
193 3KRR DQX 0.000000004733 0.78326 33.5593
194 5VC5 96M 0.0000000009894 0.75998 33.564
195 2BPM 529 0.00000002361 0.41482 33.657
196 5TO8 7FM 0.000001237 0.62812 33.6879
197 5LPB ADP 0.0000004179 0.58869 33.7838
198 4AUA 4AU 0.00000008496 0.63936 34.202
199 4E93 GUI 0.0000001047 0.67053 34.472
200 4BCM T7Z 0.0000009233 0.55167 34.5515
201 4BCQ TJF 0.00002394 0.51216 34.5515
202 4CFU 2WC 0.0000002311 0.59554 34.6535
203 2OFV 242 0.0000003297 0.65173 34.657
204 3SRV S19 0.0000000575 0.64723 34.657
205 4BCN T9N 0.0000002016 0.61456 34.6667
206 4AU8 Z3R 0.00000001761 0.64993 34.7973
207 2XMY CDK 0.00000001177 0.76354 34.8993
208 4CSV STI 0.0000008863 0.60669 34.9091
209 5LMK 6ZK 0.000002223 0.57028 35.0168
210 4QMN DB8 0.00000006664 0.68641 35.1613
211 4F4P 0SB 0.0000006785 0.66465 35.1648
212 1JPA ANP 0.000000604 0.44157 35.2564
213 4EWH T77 0.00000002455 0.69212 35.2727
214 4AT3 LTI 0.00000005621 0.6794 35.4515
215 4YMJ 4EJ 0.00000003027 0.59109 35.5263
216 3O0G 3O0 0.000000003278 0.70499 35.6164
217 1UNH IXM 0.000000008342 0.6779 35.6164
218 4YZC STU 0.000000009694 0.73031 36.0248
219 5JFS 6K0 0.0000025 0.61428 36.039
220 4D2S DYK 0.00000001484 0.66644 36.2676
221 2HK5 1BM 0.00000002969 0.67097 36.2963
222 1BYG STU 0.0000001138 0.6298 36.3309
223 5LI1 ANP 0.00000004338 0.6663 36.3354
224 4DC2 ADE 0.000000009567 0.58971 36.3354
225 5LI9 ACP 0.0000004203 0.54621 36.3354
226 4RFM 3P6 0.0000001488 0.40037 36.4662
227 4WB6 ATP 0.0000001339 0.65382 36.646
228 3FHI ANP 0.0000002982 0.63698 36.9565
229 4WB7 ATP 0.0000006876 0.63579 36.9565
230 4Y85 499 0.000007431 0.54921 36.9565
231 2GU8 796 0.00000003815 0.72639 37.2671
232 1RE8 BD2 0.0000001391 0.68582 37.2671
233 3IDB ANP 0.00000009199 0.65369 37.2671
234 2QCS ANP 0.0000001939 0.64604 37.2671
235 1ZY5 ANP 0.000004426 0.55966 37.2937
236 5FBN 5WF 0.0000001173 0.6722 37.6384
237 4U0I 0LI 0.00000003168 0.69394 37.7778
238 5H2U 1N1 0.00000008868 0.642 37.8277
239 1PHK ATP 0.000001962 0.58212 37.9195
240 5DA3 58V 0.00000001527 0.65312 38.1132
241 5UOX 8GY 0.00000001309 0.69103 38.3764
242 3SLS ANP 0.0000001673 0.63845 38.4868
243 5BVE 4VG 0.00000001231 0.75876 38.5093
244 4H3Q ANP 0.000006659 0.56485 38.5093
245 4H3P ANP 0.00001604 0.53653 38.5093
246 2F57 23D 0.0000000255 0.65977 38.8013
247 3SXS PP2 0.00000003377 0.66833 38.806
248 1CM8 ANP 0.00001925 0.53001 38.8199
249 2JLD AG1 0.000000003248 0.74744 39.1304
250 3ZRM ZRM 0.00000008094 0.64385 39.1304
251 3F7Z 34O 0.00000009363 0.6409 39.1304
252 4NM5 ADP 0.001262 0.4868 39.1304
253 2QLU ADE 0.00000008363 0.50865 39.172
254 4NST ADP 0.0000232 0.52904 39.441
255 4QTB 38Z 0.0000009864 0.61626 40.0621
256 4BHN BH9 0.00000001319 0.68763 40.6832
257 1XJD STU 0.00000002765 0.66912 40.6832
258 4OTH DRN 0.00000001491 0.68835 40.9938
259 3ALN ANP 0.000008051 0.55595 40.9938
260 5DBX ANP 0.000006098 0.54678 40.9938
261 3TXO 07U 0.0000001808 0.62054 41.6149
262 5BYZ 4WE 0.00001846 0.55777 41.6149
263 1VJY 460 0.00000006929 0.67939 42.5743
264 1V0O INR 0.00000001935 0.6764 43.0556
265 3HZT J60 0.00000002825 0.63968 43.1677
266 5TA6 79D 0.00000001225 0.70681 43.4783
267 2WEL K88 0.00000002519 0.59439 43.4783
268 3FC2 IBI 0.003324 0.47575 43.4783
269 2V7O DRN 0.00000008856 0.60375 43.7888
270 4FG8 ATP 0.0000005667 0.61043 44.127
271 5HQ0 LZ9 0.00000004042 0.66464 44.702
272 2A19 ANP 0.000001478 0.58355 44.7183
273 3SXF BK5 0.000002591 0.60529 44.7205
274 4I6H 1C8 0.0000001572 0.63038 44.8052
275 2VZ6 FEF 0.0000001722 0.61771 45.0479
276 3IGO ANP 0.000004223 0.48539 45.9627
277 5CEO 50D 0.000002818 0.57182 46
278 2VN9 GVD 0.000000004818 0.65701 46.5116
279 4L9I 8PR 0.0000143 0.53601 46.8944
280 2ZV2 609 0.000000005812 0.6965 47.3154
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