Receptor
PDB id Resolution Class Description Source Keywords
2HO2 1.33 Å NON-ENZYME: BINDING STRUCTURE OF HUMAN FE65-WW DOMAIN IN COMPLEX WITH HMENA PEPT HOMO SAPIENS WW DOMAIN BETA SHEET FE65 PROTEIN BINDING
Ref.: STRUCTURAL BASIS FOR POLYPROLINE RECOGNITION BY THE DOMAIN. J.MOL.BIOL. V. 372 970 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:101;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU B:1;
Valid;
none;
Kd = 116 uM
990.237 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HO2 1.33 Å NON-ENZYME: BINDING STRUCTURE OF HUMAN FE65-WW DOMAIN IN COMPLEX WITH HMENA PEPT HOMO SAPIENS WW DOMAIN BETA SHEET FE65 PROTEIN BINDING
Ref.: STRUCTURAL BASIS FOR POLYPROLINE RECOGNITION BY THE DOMAIN. J.MOL.BIOL. V. 372 970 2007
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 544 families.
1 2OEI Kd = 124 uM PRO PRO PRO PRO PRO PRO LEU PRO PRO n/a n/a
2 2HO2 Kd = 116 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 420 families.
1 2OEI Kd = 124 uM PRO PRO PRO PRO PRO PRO LEU PRO PRO n/a n/a
2 2HO2 Kd = 116 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 319 families.
1 2OEI Kd = 124 uM PRO PRO PRO PRO PRO PRO LEU PRO PRO n/a n/a
2 2HO2 Kd = 116 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU n/a n/a
3 4GWT - LMR C4 H6 O5 C([C@@H](C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU; Similar ligands found: 20
No: Ligand ECFP6 Tc MDL keys Tc
1 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 1 1
2 PRO PRO PRO PRO PRO PRO LEU PRO PRO 0.625 1
3 MET PRO PRO PRO PRO SEP PRO CYS THR 0.578947 0.734375
4 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.561798 0.960784
5 PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO 0.541667 0.849057
6 PRO PRO PRO VAL NMC PRO ARG ARG ARG 0.530612 0.925926
7 PRO PRO PRO PRO PRO PRO PRO PRO 0.526316 0.882353
8 PRO PRO PRO PRO PRO PRO PRO PRO PRO 0.526316 0.882353
9 MET PRO PRO PRO PRO TPO PRO ARG SER 0.525773 0.774194
10 PRO PRO PRO PRO PRO PRO PRO PRO IYR 0.520833 0.734375
11 PRO PRO PRO MET ALA GLY GLY 0.485714 0.833333
12 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.481132 0.862069
13 VAL PRO PRO PRO VAL PRO PRO PRO PRO SER 0.478261 0.892857
14 PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG 0.473214 0.980769
15 PRO PRO GLY PRO PRO GLY PRO PRO GLY 0.460674 0.87037
16 PRO PRO GLY PRO ALA GLY PRO PRO GLY 0.446602 0.857143
17 SER PRO SER PRO SER PRO SER PRO SER PRO 0.438202 0.824561
18 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.427184 0.847458
19 ACE PRO PRO PRO VAL IPG PRO ARG ARG 0.409091 0.833333
20 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.4 0.786885
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HO2; Ligand: PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2ho2.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
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