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Receptor
PDB id Resolution Class Description Source Keywords
2HNK 2.3 Å EC: 2.-.-.- CRYSTAL STRUCTURE OF SAM-DEPENDENT O-METHYLTRANSFERASE FROM BACTERIUM LEPTOSPIRA INTERROGANS LEPTOSPIRA INTERROGANS MODIFIED ROSSMAN FOLD TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF SAM-DEPENDENT O-METHYLTRANSFER PATHOGENIC BACTERIUM LEPTOSPIRA INTERROGANS. J.STRUCT.BIOL. V. 159 523 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PEG A:3001;
A:3003;
A:3004;
A:3007;
B:3006;
C:3002;
C:3005;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
submit data
106.12 C4 H10 O3 C(COC...
SAH A:2001;
B:2002;
C:2003;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
384.411 C14 H20 N6 O5 S c1nc(...
SO4 A:1001;
B:1002;
C:1003;
C:1004;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HNK 2.3 Å EC: 2.-.-.- CRYSTAL STRUCTURE OF SAM-DEPENDENT O-METHYLTRANSFERASE FROM BACTERIUM LEPTOSPIRA INTERROGANS LEPTOSPIRA INTERROGANS MODIFIED ROSSMAN FOLD TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF SAM-DEPENDENT O-METHYLTRANSFER PATHOGENIC BACTERIUM LEPTOSPIRA INTERROGANS. J.STRUCT.BIOL. V. 159 523 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 269 families.
1 2HNK - SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 237 families.
1 2HNK - SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 2HNK - SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 5LOG - LDP C8 H11 N O2 c1cc(c(cc1....
3 3CBG - FER C10 H10 O4 COc1cc(ccc....
4 5KVA Kd = 8.6 uM SAM C15 H22 N6 O5 S C[S@@+](CC....
5 3C3Y - SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HNK; Ligand: SAH; Similar sites found with APoc: 886
This union binding pocket(no: 1) in the query (biounit: 2hnk.bio1) has 23 residues
No: Leader PDB Ligand Sequence Similarity
1 1PR9 NAP None
2 2BOS GLA GAL GLC NBU None
3 3D3W NAP None
4 2BOS GLA GAL GLC None
5 1C4Q GLA GAL BGC None
6 2GUC MAN 0.83682
7 2NUO BGC 0.83682
8 2HYR BGC GLC 0.83682
9 2GUD BMA 0.83682
10 2GUD MAN 0.83682
11 2P41 SAH 1.25523
12 1RP0 AHZ 1.25523
13 4K26 NDP 1.25523
14 4K26 SFF 1.25523
15 3OZG SSI 1.25523
16 3WLE NAD 1.25523
17 1E3W NAD 1.25523
18 4P83 U5P 1.64835
19 4RPL FAD 1.67364
20 4RPL 3UC 1.67364
21 3G89 SAM 1.67364
22 5D4V SAH 1.67364
23 3U4C NDP 1.67364
24 3B1F NAD 1.67364
25 1XG5 NAP 1.67364
26 4J4H NAI 1.67364
27 4J4H 1J1 1.67364
28 1JG3 ADN 1.70213
29 5ZZ6 NAD 1.92308
30 5ZZ6 ADP 1.92308
31 1QAN SAH 2.09205
32 2RAB NAD 2.09205
33 2RAB FAD 2.09205
34 1EFV FAD 2.09205
35 1EFV AMP 2.09205
36 4M52 FAD 2.09205
37 5BVA FAD 2.09205
38 4MOP 2H5 2.09205
39 2A8X FAD 2.09205
40 3VPH NAD 2.09205
41 3VPH OXM 2.09205
42 4M52 M52 2.09205
43 3FPZ AHZ 2.09205
44 1YKJ PHB 2.09205
45 1YKJ FAD 2.09205
46 4C3Y FAD 2.09205
47 4C3Y ANB 2.09205
48 5O42 NAD 2.09205
49 5O42 9JW 2.09205
50 5O42 BGC 2.09205
51 1RYI FAD 2.09205
52 1RYI GOA 2.09205
53 3CTY FAD 2.09205
54 1CER NAD 2.09205
55 5YU3 NAD 2.09205
56 5YU3 PRO 2.09205
57 1LTH NAD 2.09205
58 3CIF NAD 2.09205
59 3OA2 NAD 2.09205
60 3CIF G3H 2.09205
61 5OJI ISN 2.09205
62 5OJI NAP 2.09205
63 4XFR CIT 2.09205
64 1EX7 5GP 2.15054
65 1XTT U5P 2.31481
66 4RDN 6MD 2.39521
67 3LXD FAD 2.40964
68 2DPM SAM 2.51046
69 3L9W AMP 2.51046
70 3L9W GSH 2.51046
71 1ZK7 FAD 2.51046
72 1GPE FAD 2.51046
73 1ELI PYC 2.51046
74 4DCM SAM 2.51046
75 3OND ADN 2.51046
76 3OND NAD 2.51046
77 4AP3 NAP 2.51046
78 4AP3 FAD 2.51046
79 2QA1 FAD 2.51046
80 1LLU NAD 2.51046
81 2GN4 NDP 2.51046
82 1M2K APR 2.51046
83 3E1T FAD 2.51046
84 1KNR FAD 2.51046
85 4Y9D NAI 2.51046
86 2GN4 UD1 2.51046
87 5MB4 NAG 2.51046
88 1OC2 TDX 2.51046
89 1OC2 NAD 2.51046
90 4K5S PM0 2.51046
91 4K5S FAD 2.51046
92 4USR FAD 2.51046
93 3RKR NAP 2.51046
94 1XHL NDP 2.51046
95 4DSG UDP 2.51046
96 4DSG FAD 2.51046
97 1IY8 NAD 2.51046
98 3ABI NAD 2.51046
99 1J0X NAD 2.51046
100 1GAD NAD 2.51046
101 1BXK NAD 2.51046
102 2WPF WPF 2.62626
103 2WPF FAD 2.62626
104 5VJN IR8 2.6738
105 1UPF URF 2.67857
106 4HA6 FAD 2.75591
107 2DT5 NAD 2.8436
108 1L7N ALF 2.8436
109 5WSY 7UC 2.89017
110 1DJL NAP 2.89855
111 5CUQ NSC 2.92887
112 6BQ6 TER 2.92887
113 4JDR FAD 2.92887
114 3EVG SAH 2.92887
115 3S5W FAD 2.92887
116 3VSE SAH 2.92887
117 2GV8 FAD 2.92887
118 1VQW FAD 2.92887
119 4X9M FAD 2.92887
120 2GVC FAD 2.92887
121 2RGJ FAD 2.92887
122 1GY8 NAD 2.92887
123 3NKS FAD 2.92887
124 3U31 NAD 2.92887
125 1DLJ UGA 2.92887
126 1DLJ NAI 2.92887
127 5MBX SP5 2.92887
128 5MBX FAD 2.92887
129 1U7T TDT 2.92887
130 1U1I NAD 2.92887
131 6DNT NAD 2.92887
132 4EIP FAD 2.92887
133 5XWV NDP 2.92887
134 5XWV 8H6 2.92887
135 1T3D CYS 2.92887
136 1ORR NAD 2.92887
137 5THQ NDP 2.92887
138 2HJR APR 2.92887
139 1WVG APR 2.92887
140 2Q0L FAD 2.92887
141 2AQJ TRP 2.92887
142 2AQJ FAD 2.92887
143 1HDG NAD 2.92887
144 2VYN NAD 2.92887
145 2JHP SAH 2.92887
146 5UAV NDP 2.92887
147 6CI9 NAP 2.92887
148 3NUG NAD 2.92887
149 1EU1 MGD 2.92887
150 6FDF SAH 2.99401
151 4POO SAM 3
152 1D4O NAP 3.26087
153 5AHO TLA 3.27381
154 4P86 5GP 3.27869
155 3ACC 5GP 3.31492
156 3GRU AMP 3.34728
157 3PT9 SAH 3.34728
158 3FPF TNA 3.34728
159 3FPF MTA 3.34728
160 2ZIF SAM 3.34728
161 3SQP FAD 3.34728
162 1LSS NAD 3.34728
163 3FUU ADN 3.34728
164 5DM1 SAH 3.34728
165 5DM1 5D7 3.34728
166 2HQM FAD 3.34728
167 4N49 SAM 3.34728
168 1FEC FAD 3.34728
169 3HDY FAD 3.34728
170 3HDY FDA 3.34728
171 3HDY GDU 3.34728
172 4D04 NAP 3.34728
173 4D04 FAD 3.34728
174 3IHG FAD 3.34728
175 2DKH FAD 3.34728
176 2DKH 3HB 3.34728
177 1P77 ATR 3.34728
178 6D6Y SAH 3.34728
179 3NDJ JHZ 3.34728
180 3NDJ SAH 3.34728
181 5O4J 9KH 3.34728
182 2Q7V FAD 3.34728
183 2NVK FAD 3.34728
184 5O4J SAH 3.34728
185 5O4J PJL 3.34728
186 3WDM ADN 3.34728
187 2NVK NAP 3.34728
188 4KGD FAD 3.34728
189 4KGD TDP 3.34728
190 4YKG NAD 3.34728
191 4YKG FAD 3.34728
192 1VKO NAD 3.34728
193 3OZ2 FAD 3.34728
194 1FL2 FAD 3.34728
195 2JHF NAD 3.34728
196 1D1T NAD 3.34728
197 3QJ4 FAD 3.34728
198 3CMC NAD 3.34728
199 2FJK 13P 3.34728
200 5J60 FAD 3.34728
201 1A0J BEN 3.34728
202 4OBW SAM 3.34728
203 1CDO NAD 3.34728
204 5UAO FAD 3.34728
205 1U3U BNF 3.34728
206 1U3U NAD 3.34728
207 2B4R AES 3.34728
208 1SB8 NAD 3.34728
209 1SB8 UD2 3.34728
210 1GTE FAD 3.34728
211 2B4R NAD 3.34728
212 6ACS CIT 3.34728
213 3EWP APR 3.38983
214 2VT3 ATP 3.72093
215 1U72 NDP 3.76344
216 1U72 MTX 3.76344
217 3VYW SAM 3.76569
218 1N2X SAM 3.76569
219 3TKA SAM 3.76569
220 3C6K SPD 3.76569
221 4UCI SAM 3.76569
222 3C6K MTA 3.76569
223 4J36 FAD 3.76569
224 4J36 1HR 3.76569
225 1T26 NAI 3.76569
226 1T26 GBD 3.76569
227 5ZYN FAD 3.76569
228 3CGD COA 3.76569
229 3P9C SAH 3.76569
230 6IS0 SAH 3.76569
231 4REP FAD 3.76569
232 3CGD FAD 3.76569
233 1PZM 5GP 3.76569
234 4U8P UDP 3.76569
235 4U8P FDA 3.76569
236 1S7G APR 3.76569
237 2FZW NAD 3.76569
238 3ZV6 NAD 3.76569
239 3CGD NAD 3.76569
240 3GF4 FAD 3.76569
241 3CGB FAD 3.76569
242 3ZV6 4HB 3.76569
243 1L7E NAI 3.76569
244 1J5P NAD 3.76569
245 1V8B NAD 3.76569
246 1USI PHE 3.76569
247 3GF4 UPG 3.76569
248 2PZM UDP 3.76569
249 2PZM NAD 3.76569
250 2GMH FAD 3.76569
251 4ZRN NAD 3.76569
252 4ZRN UPG 3.76569
253 1S7G NAD 3.76569
254 1KYQ NAD 3.76569
255 3R75 PYR 3.76569
256 5E9W SAH 3.76569
257 1ZBQ NAD 3.76569
258 1G8K MGD 3.76569
259 1GZ6 NAI 3.76569
260 5LD5 NAD 3.76569
261 4G5H UD7 3.76569
262 4G5H NAP 3.76569
263 5GT9 NAP 3.76569
264 4FWE FAD 3.76569
265 1F8G NAD 3.76569
266 5Z20 NAI 3.76812
267 2BDG PBZ 4.03587
268 5XWC 8GL 4.13043
269 5XWC NAP 4.13043
270 5XWC 2IT 4.13043
271 2WK1 SAH 4.1841
272 1X87 NAD 4.1841
273 4ONQ SFG 4.1841
274 5THY SAH 4.1841
275 5THZ SAH 4.1841
276 5J5Z FAD 4.1841
277 3ICS ADP 4.1841
278 3ICT ADP 4.1841
279 4TXI FAD 4.1841
280 4XQC NAD 4.1841
281 4XQC 13D 4.1841
282 2BRY FAD 4.1841
283 3OFK SAH 4.1841
284 4YAG NAI 4.1841
285 1YBH FAD 4.1841
286 6DEN G8A 4.1841
287 6DEN FAD 4.1841
288 6DEN TP9 4.1841
289 5WGR FAD 4.1841
290 1PN0 IPH 4.1841
291 1PN0 FAD 4.1841
292 1GR0 NAD 4.1841
293 6B92 SAH 4.1841
294 2ZXI FAD 4.1841
295 2EWM NAD 4.1841
296 3UOY NAP 4.1841
297 3UOY FAD 4.1841
298 5K0A FAD 4.1841
299 1SOW NAD 4.1841
300 1UAY ADN 4.1841
301 3ICT FAD 4.1841
302 3ICS FAD 4.1841
303 3ICR FAD 4.1841
304 2E5V FAD 4.1841
305 6GFK SAH 4.1841
306 5X68 FAD 4.1841
307 3GD4 NAD 4.1841
308 3GD4 FAD 4.1841
309 4BV6 FAD 4.1841
310 1E3I CXF 4.1841
311 2Z3Y F2N 4.1841
312 1REO FAD 4.1841
313 1UXG NAD 4.1841
314 1UXG FUM 4.1841
315 1X14 NAD 4.1841
316 1H82 GZZ 4.1841
317 1R6D NAD 4.1841
318 1R6D DAU 4.1841
319 2X1L MET 4.1841
320 1H82 FAD 4.1841
321 2AOT SAH 4.1841
322 5N6C NAD 4.1841
323 5JWC FAD 4.1841
324 4FFG 0U8 4.1841
325 3AKI AH8 4.1841
326 1KOL NAD 4.1841
327 6CEP NAD 4.1841
328 6CEP OXM 4.1841
329 1VL8 NAP 4.1841
330 4AZW SAM 4.1841
331 3NB0 G6P 4.1841
332 1E5Q NDP 4.1841
333 2PXX SAH 4.18605
334 1DQN IMU 4.34783
335 4IWN GEK 4.36681
336 1GXU 2HP 4.3956
337 4QTU SAM 4.44444
338 4PLT OXM 4.53172
339 4PLT NAI 4.53172
340 1XCL SAH 4.60251
341 1V6A TRE 4.60251
342 3MAG SAH 4.60251
343 3MCT SAH 4.60251
344 2EJU SAH 4.60251
345 1P1C SAH 4.60251
346 1JQ3 AAT 4.60251
347 4YUW 4JU 4.60251
348 4YUW S4M 4.60251
349 3GCZ SAM 4.60251
350 3BGD SAH 4.60251
351 1XHC FAD 4.60251
352 3BGD PM6 4.60251
353 4ZCC FAD 4.60251
354 4ZCC NAI 4.60251
355 3NJ4 AFX 4.60251
356 3NJ4 NAD 4.60251
357 2PX8 SAH 4.60251
358 5M67 ADE 4.60251
359 5M67 NAD 4.60251
360 2A92 NAI 4.60251
361 5M67 3D1 4.60251
362 4D5G FAD 4.60251
363 4D5G TPP 4.60251
364 5HSA FAS 4.60251
365 4D7E FAD 4.60251
366 1PS9 FAD 4.60251
367 2BD0 NAP 4.60251
368 6AIN FAD 4.60251
369 1GUZ NAD 4.60251
370 1I8T FAD 4.60251
371 1K3T BRZ 4.60251
372 2IID PHE 4.60251
373 2IID FAD 4.60251
374 4BJZ FAD 4.60251
375 4BJZ P3A 4.60251
376 5XNC MTA 4.60251
377 4FN4 NAD 4.60251
378 5ZRR 9J3 4.60251
379 1SQS TLA 4.60251
380 1OMO NAD 4.60251
381 4ZGS NAD 4.60251
382 5GUD NDP 4.60251
383 4CQM NAP 4.60251
384 2F7C CCU 4.72103
385 1EJH M7G 4.73684
386 5Z21 NAI 4.7486
387 2HMT NAI 4.86111
388 2A14 SAH 4.94297
389 3TLJ SAH 5.02092
390 1GET NAP 5.02092
391 1GET FAD 5.02092
392 2JJQ SAH 5.02092
393 4EUE NAI 5.02092
394 1O97 AMP 5.02092
395 1O97 FAD 5.02092
396 3KLJ FAD 5.02092
397 3UCL FAD 5.02092
398 3UCL CYH 5.02092
399 3UCL NAP 5.02092
400 1NVM NAD 5.02092
401 1XSE NDP 5.02092
402 5N0J FAD 5.02092
403 6EQS BV8 5.02092
404 3O7W SAM 5.02092
405 3RIY NAD 5.02092
406 5MZI FAD 5.02092
407 5MZI FYK 5.02092
408 3TKY SAH 5.02092
409 5Y77 FAD 5.02092
410 1QK3 5GP 5.02092
411 1WK8 VMS 5.02092
412 3A27 SAM 5.02092
413 1KYZ SAH 5.02092
414 1PL6 572 5.02092
415 1PL6 NAD 5.02092
416 2HK9 ATR 5.02092
417 4ITU 1HS 5.02092
418 4ITU NAI 5.02092
419 5KOX FAD 5.02092
420 5KOX RFP 5.02092
421 4OM8 NAD 5.02092
422 6GKV SAH 5.02092
423 5Z2L NDP 5.02092
424 3LU1 NAD 5.02092
425 5XLX SAH 5.02092
426 5ICE SAH 5.02092
427 5ICE 2H4 5.02092
428 6F7L FAD 5.02092
429 5EJ2 NAD 5.02092
430 1I7Q PYR 5.02092
431 2GAG NAD 5.05051
432 2FKA BEF 5.42636
433 1MO9 FAD 5.43933
434 1MO9 KPC 5.43933
435 1PJS NAD 5.43933
436 3GEG NAD 5.43933
437 2YX1 SFG 5.43933
438 4RSL FAD 5.43933
439 2YVF NAD 5.43933
440 2YVF FAD 5.43933
441 5WP4 SAH 5.43933
442 4YAC NAI 5.43933
443 2NPX NAD 5.43933
444 2YVJ FAD 5.43933
445 4YSX FAD 5.43933
446 2G5C NAD 5.43933
447 2NPX FAD 5.43933
448 1H2B NAJ 5.43933
449 1Q1R FAD 5.43933
450 2JB2 FAD 5.43933
451 2JB2 PHE 5.43933
452 3QPB URA 5.43933
453 5TOW ADN 5.43933
454 5TOW NAI 5.43933
455 3NTD FAD 5.43933
456 1OBB NAD 5.43933
457 2JBH 5GP 5.43933
458 4PIV NDP 5.43933
459 1C0I FAD 5.43933
460 1C0I BE2 5.43933
461 3NT6 FAD 5.43933
462 1AE1 NAP 5.43933
463 2VVL FAD 5.45455
464 2VVM FAD 5.45455
465 3FGZ BEF 5.46875
466 2DC1 NAD 5.50847
467 4HSU FAD 5.64516
468 4GUT FAD 5.64516
469 4GUS FAD 5.64516
470 4Z0H NAD 5.68862
471 4BUZ OCZ 5.69106
472 4BUZ OAD 5.69106
473 4BUZ NAD 5.69106
474 1R18 SAH 5.72687
475 1VE3 SAM 5.72687
476 3O9Z NAD 5.76923
477 3O9Z AKG 5.76923
478 1RJW ETF 5.85774
479 2O07 SPD 5.85774
480 2O07 MTA 5.85774
481 3G2O SAM 5.85774
482 5MIT FAD 5.85774
483 5MIT NAP 5.85774
484 2ZJ1 ARJ 5.85774
485 2ZJ1 NAD 5.85774
486 2XVF FAD 5.85774
487 4URF NAD 5.85774
488 3GGO ENO 5.85774
489 3GGO NAI 5.85774
490 2R4J 13P 5.85774
491 2R4J FAD 5.85774
492 1DJN ADP 5.85774
493 3OJO NAD 5.85774
494 4D79 ATP 5.85774
495 4RDH AMP 5.85774
496 1O94 ADP 5.85774
497 4RDI ATP 5.85774
498 2FR1 NDP 5.85774
499 3X0V FAD 5.85774
500 1X7D ORN 5.85774
501 1X7D NAD 5.85774
502 1EZ4 NAD 5.85774
503 5YEC ATP 5.88235
504 2BQP GLC 5.98291
505 4UXM BE7 6.06061
506 5A3B APR 6.27063
507 6DUB SAH 6.27615
508 1BZL GCG 6.27615
509 5JJR SAH 6.27615
510 1BZL FAD 6.27615
511 5X62 SAH 6.27615
512 2WA2 SAM 6.27615
513 2Q28 ADP 6.27615
514 4NTD FAD 6.27615
515 3AB1 FAD 6.27615
516 5IL1 SAM 6.27615
517 3NYC IAR 6.27615
518 3NYC FAD 6.27615
519 2Q1S NAI 6.27615
520 5EB4 FAD 6.27615
521 2XVE FAD 6.27615
522 5G3U FDA 6.27615
523 1L1E SAH 6.27615
524 4JNA FAD 6.27615
525 5K7U SAM 6.27615
526 1RM0 NAI 6.27615
527 1RM0 D6P 6.27615
528 6FP4 E1T 6.27615
529 6FP4 FAD 6.27615
530 2YG3 FAD 6.27615
531 5EZ7 FAD 6.27615
532 1RSG FAD 6.27615
533 3T31 DCQ 6.27615
534 3T31 FAD 6.27615
535 5W7M SAH 6.27615
536 4NBU NAI 6.27615
537 3ITJ CIT 6.27615
538 3ITJ FAD 6.27615
539 3RFV NAI 6.27615
540 1YY5 FAD 6.27615
541 3NTA FAD 6.27615
542 6BWL NAD 6.27615
543 9LDB NAD 6.27615
544 5G3U ITW 6.27615
545 3RFV 15L 6.27615
546 9LDT NAD 6.27615
547 3VSV XYP 6.27615
548 6GAR FAD 6.30372
549 1P19 IMP 6.33484
550 1NM5 NAD 6.40394
551 1NM5 NAP 6.40394
552 3FZG SAM 6.5
553 1UDB UFG 6.50888
554 1UDB NAD 6.50888
555 4JCA CIT 6.58683
556 1U2Z SAH 6.69456
557 3ELW SAM 6.69456
558 3ELW GP3 6.69456
559 1NW5 SAM 6.69456
560 1V59 FAD 6.69456
561 3EVF GTA 6.69456
562 3EVF SAH 6.69456
563 2DTX BMA 6.69456
564 4ZVV NAD 6.69456
565 2C31 ADP 6.69456
566 2C31 TZD 6.69456
567 4ZVV GN0 6.69456
568 5L95 AMP 6.69456
569 6ER9 FAD 6.69456
570 3MBI HSX 6.69456
571 6ER9 NAP 6.69456
572 4PLG OXM 6.69456
573 4PLG NAI 6.69456
574 4MO2 FDA 6.69456
575 2Q1W NAD 6.69456
576 6F97 FAD 6.69456
577 3H8V ATP 6.69456
578 4MO2 FAD 6.69456
579 6F9Q NAD 6.69456
580 1V59 NAD 6.69456
581 4IV9 FAD 6.69456
582 3KB6 NAD 6.69456
583 3L4S NAD 6.69456
584 3L4S 3PG 6.69456
585 1GV0 NAD 6.69456
586 3AI3 SOL 6.69456
587 3WV8 ATP 6.88073
588 3A25 SAM 6.97674
589 4J56 FAD 7.01754
590 1VM6 NAD 7.01754
591 1HGX 5GP 7.10383
592 4JLS 3ZE 7.11297
593 1E1M NAP 7.11297
594 1E1M FAD 7.11297
595 1E6E FAD 7.11297
596 2EG5 SAH 7.11297
597 5OC1 FAD 7.11297
598 6H3O FAD 7.11297
599 5YF1 SFG 7.11297
600 5YF1 8V0 7.11297
601 3H9E NAD 7.11297
602 5YJI SAH 7.11297
603 5YJI 8WO 7.11297
604 3LN9 FLC 7.19424
605 4II2 ATP 7.22892
606 3QOX SAH 7.53138
607 4C4A SAH 7.53138
608 5JAQ NAI 7.53138
609 5MW4 5JU 7.53138
610 4R6W PC 7.53138
611 4R6W SAH 7.53138
612 5TWB FAD 7.53138
613 1LVL FAD 7.53138
614 1BDB NAD 7.53138
615 5I39 FAD 7.53138
616 1LVL NAD 7.53138
617 5FJN BE2 7.53138
618 5FJN FAD 7.53138
619 6FHO FAD 7.53138
620 4HXY NDP 7.53138
621 2VHW NAI 7.53138
622 2EFJ SAH 7.53138
623 1C1X NAD 7.53138
624 5JCM NAD 7.53138
625 5JCM FAD 7.53138
626 5JCM ISD 7.53138
627 4AT0 FAD 7.53138
628 1BW9 NAD 7.53138
629 5OJ7 AR6 7.53138
630 1BXG NAD 7.53138
631 1SAY PYR 7.53138
632 5JE8 NAD 7.53138
633 6BU0 IHP 7.63359
634 1KPG SAH 7.66551
635 1O5O U5P 7.69231
636 3QFA FAD 7.75862
637 4KOA NDP 7.80781
638 5T9C G3P 7.83582
639 3DMH GMP 7.94979
640 3DMH SAM 7.94979
641 3VC1 SAH 7.94979
642 3VC1 GST 7.94979
643 1V5F TPP 7.94979
644 1V5F FAD 7.94979
645 3QH2 3NM 7.94979
646 5GSN NAP 7.94979
647 5GSN FAD 7.94979
648 4TM3 FAD 7.94979
649 5GSN MMZ 7.94979
650 5JCA FAD 7.94979
651 5JCA NDP 7.94979
652 1KPH SAH 8.01394
653 4X7Y SAH 8.0292
654 5O9F NAD 8.23864
655 5O9F 9ON 8.23864
656 1PNO NAP 8.33333
657 3LAD FAD 8.3682
658 4X60 SFG 8.3682
659 4X60 3XV 8.3682
660 5GWX SAM 8.3682
661 5GWX SAR 8.3682
662 6GAS FAD 8.3682
663 4GQB 0XU 8.3682
664 4YRY NAD 8.3682
665 2IVD FAD 8.3682
666 4YRY FAD 8.3682
667 3I53 SAH 8.3682
668 4USQ FAD 8.3682
669 4CNK FAD 8.3682
670 5FA5 MTA 8.3682
671 5JY6 NAD 8.3682
672 4EDF UPG 8.3682
673 3RNM FAD 8.62069
674 3M6W SAM 8.62069
675 2OOR NAD 8.62069
676 2BZG SAH 8.62069
677 2OOR TXP 8.62069
678 2CUL FAD 8.62069
679 4L2I FAD 8.78661
680 3HQ9 OXL 8.78661
681 4YJK URA 8.78661
682 5HJM MTA 8.78661
683 2CDU FAD 8.78661
684 4MIG G3F 8.78661
685 5TVF CGQ 8.78661
686 2CDU ADP 8.78661
687 5FWA J7C 8.78661
688 4RQU NAD 8.78661
689 1H5Q NAP 8.78661
690 1EJ0 SAM 8.88889
691 2XYQ SAH 9.01639
692 4FZV SAM 9.20502
693 1WG8 SAM 9.20502
694 2IZ1 ATR 9.20502
695 3AD8 NAD 9.20502
696 4DMG SAM 9.20502
697 3LZW NAP 9.20502
698 3LZW FAD 9.20502
699 5UR0 NAD 9.20502
700 5NMX FAD 9.20502
701 5NMX NAP 9.20502
702 1LDN NAD 9.20502
703 5TS5 FAD 9.20502
704 2WSB NAD 9.20502
705 3V1Y NAD 9.20502
706 3AD8 PYC 9.20502
707 3AD8 FAD 9.20502
708 1ONI BEZ 9.42029
709 1G60 SAM 9.61539
710 3X0D SAH 9.62343
711 1IM8 SAI 9.62343
712 5KOK SAH 9.62343
713 2VDV SAM 9.62343
714 5DLY SAH 9.62343
715 5DLY 5D7 9.62343
716 5KOK S9T 9.62343
717 3QVP FAD 9.62343
718 4NTC FAD 9.62343
719 5KOK R9T 9.62343
720 1J49 NAD 9.62343
721 1NJR XYL 9.62343
722 4D42 W0I 9.62343
723 4D42 NAP 9.62343
724 1RJD SAM 9.62343
725 3SJU NDP 9.62343
726 5ERG SAM 10.0418
727 3GU3 SAH 10.0418
728 1UWK NAD 10.0418
729 1UWK URO 10.0418
730 1JQD SAH 10.0418
731 5BUK FAD 10.0418
732 1UP7 NAD 10.0418
733 1UTJ ABN 10.0418
734 1JNR FAD 10.0418
735 4YT4 FE9 10.0418
736 1WY7 SAH 10.1449
737 1I1N SAH 10.177
738 5ODQ FAD 10.3261
739 5U8U FAD 10.4603
740 4B63 ORN 10.4603
741 4B63 FAD 10.4603
742 4B63 NAP 10.4603
743 1A5Z NAD 10.4603
744 2Y6Q I7T 10.4603
745 2Y6Q FAD 10.4603
746 2DFV NAD 10.4603
747 3AYI FAD 10.4603
748 3AYI HCI 10.4603
749 5MPT SAH 10.8787
750 3S1S SAH 10.8787
751 5BRT CH9 10.8787
752 5BRT FAD 10.8787
753 1PZG A3D 10.8787
754 2C7G FAD 10.8787
755 2C7G ODP 10.8787
756 5FTW SAH 10.8787
757 3GFB NAD 10.8787
758 3ZNN FAD 10.8787
759 3ZNN 4WL 10.8787
760 2FK8 SAM 11.0063
761 4BLW AMP 11.0727
762 4BLW SAH 11.0727
763 3Q87 SAM 11.2
764 1Q0S SAH 11.2971
765 3A4T SFG 11.2971
766 5WP5 SAH 11.2971
767 4YNU FAD 11.2971
768 4YNU LGC 11.2971
769 5Z75 NAD 11.2971
770 1Y8Q ATP 11.7155
771 4EMI NAD 11.7155
772 4EMI FAD 11.7155
773 1XKQ NDP 11.7155
774 2IXB NAD 11.7155
775 2IXB A2G 11.7155
776 3O03 NAP 11.7155
777 1TPY SAH 12.1339
778 1MUU NAD 12.1339
779 1MV8 NAD 12.1339
780 1SC6 NAD 12.1339
781 1P4A PCP 12.1339
782 3DXY SAM 12.3853
783 2PS1 ORO 12.3894
784 3JWH SAH 12.4424
785 4IF4 BEF 12.5
786 3AXB FAD 12.5523
787 3AXB PRO 12.5523
788 4OPC FDA 12.5523
789 4OPC PGT 12.5523
790 4GKV NAD 12.7976
791 1T9D PYD 12.9707
792 1T9D 1MM 12.9707
793 1T9D FAD 12.9707
794 1T9D P25 12.9707
795 5WKC FAD 12.9707
796 4FC7 NAP 12.9707
797 4FC7 COA 12.9707
798 1DL5 SAH 13.3891
799 3CH6 311 13.3891
800 3CH6 NAP 13.3891
801 1I2B USQ 13.3891
802 1I2B NAD 13.3891
803 1I2B UPG 13.3891
804 5KKA 6V0 13.3891
805 5WHU SIA GAL GLC 13.4228
806 5E8J SAH 13.6364
807 1NAA ABL 13.8075
808 1NAA 6FA 13.8075
809 1Q9I FAD 13.8075
810 1Q9I TEO 13.8075
811 6F3N ADN 13.8075
812 6F3N NAD 13.8075
813 6F3M NAD 13.8075
814 3GMB FAD 13.8075
815 5HXI FAD 13.8075
816 5HXI 5HN 13.8075
817 1Z45 NAD 13.8075
818 4EMJ FAD 14.0187
819 3GDH SAH 14.2259
820 4PIO SAH 14.2259
821 4PIO AVI 14.2259
822 4OB1 BUB 14.2259
823 4OB0 PBC 14.2857
824 3GXO SAH 14.6444
825 1HYH NAD 14.6444
826 3GWZ SAH 14.6444
827 6ARJ BW4 15.0628
828 6ARJ SAH 15.0628
829 5DX1 SFG 15.0628
830 5DWQ SFG 15.0628
831 5DX8 SFG 15.0628
832 5DXA SFG 15.0628
833 5FUB SAH 15.0628
834 2XVM SAH 15.0628
835 5DX0 SFG 15.0628
836 1NV8 SAM 15.0628
837 1NV8 MEQ 15.0628
838 1DSS NAD 15.4812
839 2F5Z FAD 15.625
840 1G55 SAH 15.8996
841 4A6D SAM 15.8996
842 5E1M SAH 16.318
843 5E1M PRO PRO LYS ARG ILE ALA 16.318
844 1ZEM NAD 16.318
845 3EGI ADP 16.5049
846 1ZQ9 SAM 16.7364
847 4M73 SAH 17.1548
848 4M73 M72 17.1548
849 2PT9 2MH 17.1548
850 2PT9 S4M 17.1548
851 2I7C AAT 17.1548
852 1D4D FAD 17.1548
853 3LCC SAH 17.1548
854 1L5Y BEF 17.4194
855 3MB5 SAM 17.9916
856 3SSO SAH 17.9916
857 5W7K SAH 17.9916
858 5BJX NAD 18.41
859 5BJX UDP 18.41
860 5MGZ SAH 18.6441
861 5M58 SAH 18.6957
862 1XDS SAM 18.8285
863 5VN0 NAI 19.6653
864 5VN0 FAD 19.6653
865 4Y30 49L 20.0837
866 4Y30 SAH 20.0837
867 1COY FAD 20.9205
868 1COY AND 20.9205
869 2B9W FAD 20.9205
870 1QO8 FAD 22.1757
871 2RGO FAD 22.1757
872 4M37 SAH 23.0126
873 4M38 SAH 23.0126
874 2NXE SAM 23.431
875 2PWY SAH 23.8494
876 5KMS NAD 26.7782
877 5KMS FAD 26.7782
878 1Z3C SA8 27.6151
879 4Z24 FAD 32.2176
880 3HVJ 705 33.8912
881 4XUC SAM 34.728
882 4XUC 43G 34.728
883 3GDN HBX 37.6569
884 3GDN FAD 37.6569
885 3DUW SAH 45.7399
886 5ZW3 SAH 48.4444
Pocket No.: 2; Query (leader) PDB : 2HNK; Ligand: SAH; Similar sites found with APoc: 64
This union binding pocket(no: 2) in the query (biounit: 2hnk.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 5NNT DPV None
2 1E6W NAD 1.25523
3 2D3N GLC GLC GLC 2.09205
4 6HOY TSN 2.09205
5 6HOY AR6 2.09205
6 1EDO NAP 2.51046
7 4JK3 NAD 2.51046
8 2QQF A1R 2.51046
9 1SZD APR 2.51046
10 4B4U NAP 2.92887
11 1GQ2 NAP 3.34728
12 3ZFD ANP 3.34728
13 6BS6 GLC GLC GLC 3.76569
14 5F7J ADE 3.76569
15 3B1J NAD 3.76569
16 3TN7 NJP 3.76569
17 3G5S FAD 4.1841
18 1LDM NAD 4.1841
19 1MJT NAD 4.1841
20 5GUD 2IT 4.60251
21 5TTJ FAD 4.60251
22 4NBW NAD 5.02092
23 2YY7 NAD 5.02092
24 1W6F ISZ 5.02092
25 2HK9 NAP 5.02092
26 4LWM MHO 5.43933
27 2OQ5 BEN 5.43933
28 4TQK NAG 5.85774
29 1Q0H NDP 5.85774
30 1Q0H FOM 5.85774
31 1OAA OAA 5.85774
32 1RLZ NAD 6.27615
33 2JAH NDP 6.47773
34 4OOE FOM 6.69456
35 4OOE NDP 6.69456
36 3NRR D16 6.69456
37 5Y02 HBX 6.69456
38 5FEU NAP 6.87285
39 2RBK VN4 6.89655
40 5NA1 FAD 7.11297
41 2EV9 NAP 7.11297
42 2EV9 SKM 7.11297
43 4JSR 1NQ 8.07018
44 1JQY A32 8.73786
45 5EEH P9P 8.78661
46 5EEH SAH 8.78661
47 4WOH 4NP 9.03614
48 1YQZ FAD 9.20502
49 1FWV SGA MAG FUC 9.20502
50 3ETG GLU 9.62343
51 3ETG GTP 9.62343
52 3ETG NDP 9.62343
53 1KEW NAD 10.0418
54 3WGT QSC 10.8787
55 5YAP NAI 11.7155
56 5YAP 8S0 11.7155
57 2VPY MGD 12.6482
58 3QV1 NAD 13.4146
59 4I5I NAD 13.8075
60 4KXQ APR 13.8075
61 3EYA FAD 13.8075
62 5TP0 BRN 14.2259
63 2AJH MET 16.318
64 1YXM ADE 16.7364
Pocket No.: 3; Query (leader) PDB : 2HNK; Ligand: SAH; Similar sites found with APoc: 19
This union binding pocket(no: 3) in the query (biounit: 2hnk.bio2) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 2HYQ MAN MAN 0.83682
2 1JA9 NDP 1.67364
3 5KJW 53C 2.51046
4 3ICC NAP 2.51046
5 1YQD NAP 3.34728
6 1I7M CG 4.49438
7 5Y8L NAD 5.02092
8 2GAG FAD 5.05051
9 5ZI2 NAD 5.43933
10 1YC5 NCA 5.69106
11 4XOE KGM 5.85774
12 5DY5 5GR 7.11297
13 5X7Q GLC GLC GLC GLC 9.20502
14 2AE2 NAP 9.20502
15 2AE2 PTO 9.20502
16 1R37 NAD 10.3746
17 3WGT FAD 10.8787
18 5EIN NAP 16.6667
19 6GNO XDI 17.7778
Pocket No.: 4; Query (leader) PDB : 2HNK; Ligand: SAH; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2hnk.bio2) has 22 residues
No: Leader PDB Ligand Sequence Similarity
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