Receptor
PDB id Resolution Class Description Source Keywords
2HI8 1.64 Å EC: 7.-.-.- HUMAN FORMYLGLYCINE GENERATING ENZYME, C336S MUTANT, BROMIDE CRYSTALLIZATION HOMO SAPIENS HYDROLASE ACTIVATOR PROTEIN BINDING FORMYLGLYCIN GENERATIOTRANSLATIONAL MODIFICATION ENDOPLASMIC RETICULUM SULFATAS
Ref.: PROBING THE OXYGEN-BINDING SITE OF THE HUMAN FORMYLGLYCINE-GENERATING ENZYME USING HALIDE IONS. ACTA CRYSTALLOGR.,SECT.D V. 63 621 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BR X:1001;
X:1002;
X:1003;
X:1004;
X:1005;
X:1006;
X:1007;
X:1008;
X:1009;
X:1010;
X:1011;
X:1012;
X:1013;
X:1014;
X:1015;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
79.904 Br [Br-]
CA X:1016;
X:1017;
Part of Protein;
Part of Protein;
none;
none;
submit data
40.078 Ca [Ca+2...
CL X:1018;
Invalid;
none;
submit data
35.453 Cl [Cl-]
CYS THR PRO SER ARG P:1;
Valid;
none;
submit data
563.657 n/a SCC([...
NAG NAG X:1;
Part of Protein;
none;
submit data
408.404 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HI8 1.64 Å EC: 7.-.-.- HUMAN FORMYLGLYCINE GENERATING ENZYME, C336S MUTANT, BROMIDE CRYSTALLIZATION HOMO SAPIENS HYDROLASE ACTIVATOR PROTEIN BINDING FORMYLGLYCIN GENERATIOTRANSLATIONAL MODIFICATION ENDOPLASMIC RETICULUM SULFATAS
Ref.: PROBING THE OXYGEN-BINDING SITE OF THE HUMAN FORMYLGLYCINE-GENERATING ENZYME USING HALIDE IONS. ACTA CRYSTALLOGR.,SECT.D V. 63 621 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 293 families.
1 2HI8 - CYS THR PRO SER ARG n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 250 families.
1 2HI8 - CYS THR PRO SER ARG n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 204 families.
1 2HI8 - CYS THR PRO SER ARG n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: CYS THR PRO SER ARG; Similar ligands found: 134
No: Ligand ECFP6 Tc MDL keys Tc
1 CYS THR PRO SER ARG 1 1
2 SER LEU SER ARG THR PRO ALA ASP GLY ARG 0.581395 0.938462
3 SER ALA PRO ASP THR ARG PRO ALA 0.57377 0.910448
4 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.556452 0.924242
5 ASN ARG PRO ILE LEU SER LEU 0.536585 0.882353
6 GLU PRO GLY GLY SER ARG 0.534483 0.90625
7 ALA PRO ASP THR ARG PRO 0.533898 0.895522
8 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.532258 0.924242
9 SER ARG ASP HIS SER ARG THR PRO MET 0.531469 0.849315
10 MET CYS PRO ARG MET THR ALA VAL MET 0.529851 0.884058
11 THR LYS PRO ARG 0.528846 0.825397
12 DPN PRO DAR DTH NH2 0.525862 0.90625
13 ARG THR PRO SEP LEU PRO THR 0.52381 0.808219
14 GLN ARG SER THR SEP THR PRO ASN VAL HIS 0.522388 0.833333
15 SER GLU CYS THR THR PRO CYS 0.517241 0.875
16 ALA ARG MLZ SER ALA PRO ALA THR 0.515625 0.884058
17 THR PRO ARG VAL THR GLY GLY GLY ALA MET 0.514925 0.859155
18 ALA PHE ARG ILE PRO LEU THR ARG 0.514706 0.869565
19 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.511278 0.897059
20 THR PRO ARG ARG SER MLZ SER ALA 0.508333 0.869565
21 ARG ARG ARG GLU ARG SER PRO THR ARG 0.507812 0.953125
22 ACE GLN GLU ARG GLU VAL PRO CYS 0.504065 0.820895
23 ALA PRO ASP THR ARG PRO ALA PRO 0.504065 0.895522
24 ALA MET ALA PRO ARG THR LEU LEU LEU 0.503876 0.857143
25 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.503817 0.821918
26 ARG VAL ALA SER PRO THR SER GLY VAL 0.5 0.938462
27 GLU ARG THR ILE PRO ILE THR ARG GLU 0.5 0.893939
28 SER PRO LYS ARG ILE ALA 0.5 0.892308
29 DPN PRO ARG 0.5 0.8125
30 LYS PRO VAL LEU ARG THR ALA 0.496124 0.893939
31 DPN PRO DAR CYS NH2 0.487179 0.828125
32 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.484848 0.895522
33 ARG PRO LYS ARG ILE ALA 0.47619 0.833333
34 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.475524 0.847222
35 ALA ASN SER ARG HIS PRO THR SER ILE ILE 0.474453 0.871429
36 5JP PRO LYS ARG ILE ALA 0.474138 0.850746
37 ARG SER ARG 0.473684 0.741935
38 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.472603 0.910448
39 LYS LEU THR PRO LEU CYS VAL THR LEU 0.46875 0.833333
40 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.468085 0.869565
41 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.466667 0.824324
42 ACE ARG THR PRO SEP LEU PRO THR PIP 0.466667 0.766234
43 1IP CYS PHE SER LYS PRO ARG 0.464789 0.897059
44 ASN LEU VAL PRO SER VAL ALA THR VAL 0.464567 0.820895
45 DPN PRO DAR ILE NH2 0.46281 0.776119
46 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.462121 0.878788
47 ALA ASN SER ARG ALY PRO THR SER ILE ILE 0.462069 0.871429
48 ARG VAL ALA SEP PRO THR SER GLY VAL 0.460432 0.859155
49 VAL PRO LEU ARG PRO MET THR TYR 0.458333 0.824324
50 LEU ASP PRO ARG 0.457627 0.833333
51 SER HIS PRO ARG PRO ILE ARG VAL 0.457143 0.84507
52 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.456522 0.788732
53 ARG THR PHE SER PRO THR TYR GLY LEU 0.455782 0.835616
54 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.455782 0.884058
55 PRO THR PRO SER ALA PRO VAL PRO LEU 0.453782 0.808824
56 PHE ASN ARG PRO VAL 0.453125 0.823529
57 GLU LYS PRO SER SER SER 0.452174 0.828125
58 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.448529 0.811594
59 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.447761 0.808824
60 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.44697 0.785714
61 LEU PRO PHE ASP ARG THR THR ILE MET 0.446667 0.835616
62 SER PRO HIS ASN PRO ILE SER ASP VAL ASP 0.446281 0.782609
63 SER THR CYS PRO ALA ALA 0.445455 0.873016
64 TYR PRO LYS ARG ILE ALA 0.445255 0.788732
65 LEU GLN ARG VAL LEU SEP ALA PRO PHE 0.443662 0.783784
66 ASP LEU THR ARG PRO 0.442623 0.909091
67 ALA ALA ARG KCR SER ALA PRO ALA 0.442029 0.893939
68 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.439716 0.777778
69 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 0.438849 0.788732
70 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.438272 0.813333
71 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.437956 0.802817
72 PRO SER ARG VAL 0.436364 0.828125
73 GLN ALA SER TPO PRO ARG NIT 0.436242 0.731707
74 VAL MET ALA PRO ARG THR LEU PHE LEU 0.436242 0.833333
75 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.434211 0.84507
76 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.433824 0.910448
77 GLY MET PRO ARG GLY ALA 0.433071 0.785714
78 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.432432 0.763889
79 LEU PRO PHE GLU ARG ALA THR VAL MET 0.432258 0.833333
80 SER SER GLY LYS VAL PRO LEU 0.432 0.791045
81 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.431655 0.797101
82 SER SER GLY LYS VAL PRO LEU SER 0.429688 0.80597
83 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.428571 0.80303
84 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.428571 0.792208
85 ALA THR PRO PHE GLN GLU 0.428571 0.769231
86 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.428571 0.882353
87 PRO SER ILE ASP ARG SER THR LYS PRO 0.424658 0.897059
88 LYS ARG ARG ARG HIS PRO SER GLY 0.42446 0.852941
89 PRO ARG ARG PRO VAL ILE MET ARG ARG 0.42446 0.760563
90 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.421429 0.811594
91 SER PRO ILE VAL PRO SER PHE ASP MET 0.42069 0.743243
92 SER VAL PRO ILE 0.420561 0.80303
93 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.420382 0.821918
94 LEU PRO PHE GLU ARG ALA THR ILE MET 0.417722 0.821918
95 ARG SEP PRO VAL PHE SER 0.416667 0.805556
96 ARG THR PRO SEP LEU PRO GLY D4K 0.416149 0.728395
97 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.416 0.818182
98 PRO PRO LYS ARG ILE ALA 0.414815 0.80597
99 LEU PRO SER PHE GLU THR ALA LEU 0.414286 0.808824
100 ARG ARG ALA SEP ALA PRO LEU PRO 0.414286 0.77027
101 ARG VAL SER PRO SER THR SER TYR THR PRO 0.414062 0.782609
102 SER PRO ARG LEU PRO LEU LEU GLU SER 0.414062 0.776119
103 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.413793 0.774648
104 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.4125 0.8
105 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.412214 0.753623
106 SER SER TYR ARG ARG PRO VAL GLY ILE 0.412162 0.821918
107 DMG PRO ARG ARG ARG SER ARG LYS PRO 0.411765 0.826087
108 SER LEU ILE PRO TPO PRO ASP LYS 0.411348 0.746667
109 HIS HIS ALA SER PRO ARG LYS 0.410959 0.838235
110 ASN LEU VAL PRO THR VAL ALA THR VAL 0.410853 0.791045
111 LEU PRO GLU THR GLY 0.410256 0.80303
112 ARG PRO MET THR PHE LYS GLY ALA LEU 0.409938 0.821918
113 ILE SER PRO ARG THR LEU ASP ALA TRP 0.409639 0.824324
114 ARG PRO LYS PRO LEU VAL ASP PRO 0.409449 0.791045
115 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.409396 0.760563
116 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.408805 0.833333
117 ASN LEU VAL PRO VAL VAL ALA THR VAL 0.407692 0.791045
118 ARG PRO MET THR TYR LYS GLY ALA LEU 0.407407 0.789474
119 GLY THR SER SER PRO SER ALA ASP 0.406504 0.84375
120 ASP SER THR THR PRO ALA PRO THR 0.405405 0.757576
121 SER SER CYS PRO LEU SER LYS 0.404762 0.818182
122 ILE PRO LEU THR GLU GLU ALA GLU LEU 0.40458 0.764706
123 ASN LEU VAL PRO GLN VAL ALA THR VAL 0.404412 0.791045
124 3BY PRO LYS ARG ILE ALA 0.404412 0.774648
125 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.40411 0.785714
126 GLU PTR LEU GLY LEU ASP VAL PRO VAL 0.403509 0.727273
127 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.402778 0.805556
128 ALA PRO THR 0.402062 0.75
129 ALA PRO ASP THR ARG PRO A2G 0.401316 0.824324
130 ARG PHE PRO LEU THR PHE GLY TRP 0.401235 0.797297
131 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.401198 0.802632
132 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.4 0.782051
133 ARG GLU ARG SER PRO THR ARG 0.4 0.90625
134 TYR SEP PRO THR SEP PRO SER 0.4 0.756757
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
Feedback