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Receptor
PDB id Resolution Class Description Source Keywords
2GUC 1.79 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A COMPLEX OF GRIFFITHSIN WITH MANNOSE A RESOLUTION. GRIFFITHSIA GRIFFITHSIN LECTINS DOMAIN SWAPPING MANNOSE BINDING HIVSUGAR BINDING PROTEIN
Ref.: DOMAIN-SWAPPED STRUCTURE OF THE POTENT ANTIVIRAL PR GRIFFITHSIN AND ITS MODE OF CARBOHYDRATE BINDING. STRUCTURE V. 14 1127 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:402;
Invalid;
none;
submit data
62.068 C2 H6 O2 C(CO)...
MAN A:122;
A:123;
A:124;
A:125;
B:122;
B:123;
B:124;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
submit data
180.156 C6 H12 O6 C([C@...
SO4 B:401;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2GUC 1.79 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A COMPLEX OF GRIFFITHSIN WITH MANNOSE A RESOLUTION. GRIFFITHSIA GRIFFITHSIN LECTINS DOMAIN SWAPPING MANNOSE BINDING HIVSUGAR BINDING PROTEIN
Ref.: DOMAIN-SWAPPED STRUCTURE OF THE POTENT ANTIVIRAL PR GRIFFITHSIN AND ITS MODE OF CARBOHYDRATE BINDING. STRUCTURE V. 14 1127 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 2GUC - MAN C6 H12 O6 C([C@@H]1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 2GUC - MAN C6 H12 O6 C([C@@H]1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 2GUC - MAN C6 H12 O6 C([C@@H]1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MAN; Similar ligands found: 142
No: Ligand ECFP6 Tc MDL keys Tc
1 WOO 1 1
2 GLC 1 1
3 BGC 1 1
4 ALL 1 1
5 BMA 1 1
6 GXL 1 1
7 GIV 1 1
8 GAL 1 1
9 MAN 1 1
10 GLA 1 1
11 Z6J 0.653846 0.866667
12 32O 0.653846 0.866667
13 RIB 0.653846 0.866667
14 FUB 0.653846 0.866667
15 AHR 0.653846 0.866667
16 MLB 0.511628 0.848485
17 GLC GLC 0.511628 0.848485
18 BGC GLC 0.511628 0.848485
19 BGC GLA 0.511628 0.848485
20 GLA BMA 0.511628 0.848485
21 MAN BMA 0.511628 0.848485
22 BMA GLA 0.511628 0.848485
23 GLA BGC 0.511628 0.848485
24 MAN MAN 0.511628 0.848485
25 GLA GLC 0.511628 0.848485
26 BMA MAN 0.511628 0.848485
27 GAL GLC 0.511628 0.848485
28 GAL GAL 0.511628 0.848485
29 LAK 0.511628 0.848485
30 GLC BGC 0.511628 0.848485
31 YDR 0.5 0.8
32 GLC GLC GLC GLC BGC 0.488889 0.848485
33 GLC GLC GLC 0.488889 0.848485
34 MAN MAN MAN 0.488889 0.848485
35 BMA MAN MAN 0.488889 0.848485
36 GLC GLC GLC GLC GLC BGC 0.488889 0.848485
37 EMZ 0.472222 0.794118
38 BG6 0.461538 0.675
39 BGP 0.461538 0.675
40 G6P 0.461538 0.675
41 M6P 0.461538 0.675
42 M6D 0.461538 0.675
43 A6P 0.461538 0.675
44 GAF 0.457143 0.875
45 SHG 0.457143 0.875
46 2FG 0.457143 0.875
47 G2F 0.457143 0.875
48 2H5 0.457143 0.875
49 GCS 0.457143 0.777778
50 1GN 0.457143 0.777778
51 X6X 0.457143 0.777778
52 PA1 0.457143 0.777778
53 95Z 0.457143 0.777778
54 G3F 0.457143 0.875
55 NGR 0.454545 0.848485
56 MAL 0.454545 0.848485
57 MAN GLC 0.454545 0.848485
58 GAL BGC 0.454545 0.848485
59 GLA GLA 0.454545 0.848485
60 BGC BMA 0.454545 0.848485
61 M3M 0.454545 0.848485
62 GLA GAL 0.454545 0.848485
63 MAB 0.454545 0.848485
64 GLC GAL 0.454545 0.848485
65 B2G 0.454545 0.848485
66 LBT 0.454545 0.848485
67 BMA GAL 0.454545 0.848485
68 LAT 0.454545 0.848485
69 BGC GAL 0.454545 0.848485
70 CBI 0.454545 0.848485
71 CBK 0.454545 0.848485
72 N9S 0.454545 0.848485
73 LB2 0.454545 0.848485
74 3MG 0.444444 0.875
75 TCB 0.444444 0.8
76 GLC SGC 0.444444 0.8
77 YIO 0.441176 0.870968
78 2GS 0.432432 0.875
79 2M4 0.431818 0.848485
80 AHR AHR 0.428571 0.764706
81 GLF 0.428571 0.84375
82 FUB AHR 0.428571 0.764706
83 MAN BMA BMA 0.416667 0.848485
84 BMA MAN BMA 0.416667 0.848485
85 CTR 0.416667 0.848485
86 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.416667 0.848485
87 GLA GAL BGC 0.416667 0.848485
88 CE5 0.416667 0.848485
89 MLR 0.416667 0.848485
90 CE6 0.416667 0.848485
91 MT7 0.416667 0.848485
92 BMA BMA BMA 0.416667 0.848485
93 GLC BGC BGC BGC BGC 0.416667 0.848485
94 MAN MAN BMA BMA BMA BMA 0.416667 0.848485
95 BGC BGC BGC BGC BGC 0.416667 0.848485
96 BGC GLC GLC GLC GLC GLC GLC 0.416667 0.848485
97 BGC GLC GLC 0.416667 0.848485
98 BMA BMA BMA BMA BMA 0.416667 0.848485
99 MAN BMA BMA BMA BMA 0.416667 0.848485
100 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.416667 0.848485
101 GLC BGC BGC BGC BGC BGC 0.416667 0.848485
102 MAN BMA BMA BMA BMA BMA 0.416667 0.848485
103 BGC BGC BGC BGC BGC BGC 0.416667 0.848485
104 BGC GLC GLC GLC 0.416667 0.848485
105 BGC BGC BGC GLC 0.416667 0.848485
106 CTT 0.416667 0.848485
107 GLA GAL GLC 0.416667 0.848485
108 MTT 0.416667 0.848485
109 GLC BGC BGC BGC 0.416667 0.848485
110 GLC GLC BGC 0.416667 0.848485
111 CEY 0.416667 0.848485
112 B4G 0.416667 0.848485
113 CE8 0.416667 0.848485
114 BMA BMA BMA BMA BMA BMA 0.416667 0.848485
115 GAL FUC 0.416667 0.848485
116 DXI 0.416667 0.848485
117 GLC BGC GLC 0.416667 0.848485
118 CT3 0.416667 0.848485
119 GAL GAL GAL 0.416667 0.848485
120 GLC GLC GLC GLC GLC 0.416667 0.848485
121 BGC BGC BGC BGC 0.416667 0.848485
122 BGC BGC BGC 0.416667 0.848485
123 BGC BGC GLC 0.416667 0.848485
124 CEX 0.416667 0.848485
125 GLC GAL GAL 0.416667 0.848485
126 BGC GLC GLC GLC GLC 0.416667 0.848485
127 GLC BGC BGC 0.416667 0.848485
128 GS1 GLC GS1 0.408163 0.8
129 SGC SGC BGC 0.408163 0.8
130 BGC BGC BGC GLC BGC BGC 0.408163 0.848485
131 GLC BGC BGC BGC BGC BGC BGC 0.408163 0.848485
132 1LL 0.405405 0.771429
133 TDG 0.405405 0.771429
134 TRE 0.405405 0.848485
135 NDG 0.404762 0.7
136 NGA 0.404762 0.7
137 NAG 0.404762 0.7
138 HSQ 0.404762 0.7
139 A2G 0.404762 0.7
140 BM3 0.404762 0.7
141 FUB AHR AHR 0.4 0.764706
142 AHR AHR AHR AHR AHR AHR 0.4 0.764706
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2GUC; Ligand: MAN; Similar sites found with APoc: 286
This union binding pocket(no: 1) in the query (biounit: 2guc.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 2BQP GLC None
2 1OFS SUC None
3 1LES GLC FRU None
4 1WPY BTN None
5 2O07 SPD None
6 2O07 MTA None
7 1N2X SAM None
8 4KYQ FLC None
9 2DXU BT5 None
10 4KCT PYR 1.63934
11 2CVQ NDP 1.63934
12 2JE7 XMM 2.45902
13 3GD4 FAD 2.45902
14 1HYH NAD 2.45902
15 3RFV NAI 2.45902
16 5N81 8Q2 2.45902
17 1PZG A3D 3.27869
18 5BVA FAD 3.27869
19 5X9D 80F 3.27869
20 1DJN ADP 3.27869
21 5O98 NAP 3.27869
22 2JFN GLU 3.27869
23 3OU2 SAH 3.27869
24 4MO2 FDA 4.09836
25 5ZYN FAD 4.09836
26 4MO2 FAD 4.09836
27 1SOW NAD 4.09836
28 5BUK FAD 4.09836
29 6GKV SAH 4.09836
30 16PK BIS 4.09836
31 6HOY AR6 4.09836
32 6HOY TSN 4.09836
33 3ZG6 APR 4.09836
34 6AM8 TRP 4.09836
35 4TW7 37K 4.09836
36 3TKY SAH 4.09836
37 3VPH OXM 4.19355
38 3VPH NAD 4.19355
39 3CW9 01A 4.91803
40 4O4F ATP 4.91803
41 4O4F IHP 4.91803
42 3KLJ FAD 4.91803
43 2PUL ACP 4.91803
44 3P3G UKW 4.91803
45 3P3G 3P3 4.91803
46 4ZGS NAD 4.91803
47 3NZK C90 4.91803
48 5VN0 NAI 4.91803
49 1A5Z NAD 4.91803
50 3AY6 NAI 4.91803
51 1QO8 FAD 4.91803
52 1ZEM NAD 4.91803
53 4GKY MAN 4.91803
54 3GDN FAD 4.91803
55 2Q3R FMN 4.91803
56 2XVF FAD 4.91803
57 3SJ7 NDP 4.91803
58 2ZXI FAD 5.7377
59 4D04 NAP 5.7377
60 4D04 FAD 5.7377
61 4O33 TZN 5.7377
62 4O33 3PG 5.7377
63 2XVE FAD 5.7377
64 3C6K SPD 5.7377
65 4HKP TKW 5.7377
66 1VPE ANP 5.7377
67 3CGB FAD 5.7377
68 1RM4 NDP 5.7377
69 3QV1 NAD 5.7377
70 3C6K MTA 5.7377
71 4L77 CNL 5.7377
72 5EYY MDM 6.55738
73 2PHU MAN MAN 6.55738
74 2GNM MAN 6.55738
75 2PHU MAN MAN MAN BMA MAN 6.55738
76 2PHF MAN MAN BMA MAN 6.55738
77 2PHT MAN MAN MAN BMA MAN 6.55738
78 2PHF MAN MAN 6.55738
79 3ZYR NAG NAG BMA MAN MAN NAG NAG 6.55738
80 2PHT MAN MAN MAN 6.55738
81 2AUY NAG MAN MMA 6.55738
82 2GN3 MAN 6.55738
83 2GN3 MMA 6.55738
84 3ZYR ASN NAG NAG BMA MAN MAN NAG NAG 6.55738
85 2GNB MAN 6.55738
86 2GMM MAN MAN 6.55738
87 1Q8Q MAN MMA 6.55738
88 1UKG MMA 6.55738
89 1Q8S MAN MMA 6.55738
90 2GND MAN 6.55738
91 1Q8V MAN MAN 6.55738
92 1LOF MAN BMA NAG NAG MAN NAG GAL GAL 6.55738
93 1Q8O MAN MMA 6.55738
94 1Q8V MAN MAN MAN 6.55738
95 2GND MAN MMA 6.55738
96 2PHW MAN MAN 6.55738
97 2PHR MAN MAN 6.55738
98 1Q8P MAN MMA 6.55738
99 2PHX MAN MAN MAN MAN 6.55738
100 2PHR MAN MAN BMA MAN 6.55738
101 2PHX MAN MAN 6.55738
102 2GMP NAG MAN 6.55738
103 2PHW MAN MAN MAN BMA MAN MAN MAN 6.55738
104 1LOB MMA 6.55738
105 3NKS FAD 6.55738
106 5L4S 6KX 6.55738
107 5L4S NAP 6.55738
108 2YVF NAD 6.55738
109 2AR6 NAG MAN 6.55738
110 1OFD AKG 6.55738
111 1OFD FMN 6.55738
112 6GAR FAD 6.55738
113 2CUL FAD 6.55738
114 5A1S FLC 6.55738
115 2CUN 3PG 6.55738
116 2HJR APR 6.55738
117 1YQS BSA 6.55738
118 2AR6 NAG MAN MAN MAN NAG 6.55738
119 5NNA BZM 6.55738
120 5YLT SFG 6.55738
121 4MCC 21X 6.55738
122 1GUZ NAD 6.55738
123 2D3S TNR 6.55738
124 1GPE FAD 6.55738
125 2OFD NGA 7.04225
126 5OVL NAP 7.37705
127 1N5D NDP 7.37705
128 5OVK NDP 7.37705
129 4RPL FAD 7.37705
130 4RPL 3UC 7.37705
131 1BXG NAD 7.37705
132 5WS9 AMP 7.37705
133 5U3B 7TD 7.37705
134 4D42 W0I 7.37705
135 4D42 NAP 7.37705
136 1T3Q FAD 7.37705
137 6A3J SOE 7.37705
138 6A3J NAI 7.37705
139 1F8G NAD 7.37705
140 2QFY AKG 7.37705
141 4UX9 ANP 7.37705
142 1LVW TYD 7.37705
143 2RGO FAD 7.37705
144 4M00 SUC 8.19672
145 1AE1 NAP 8.19672
146 5Z20 NAI 8.19672
147 1RYI FAD 8.19672
148 1RYI GOA 8.19672
149 2VPQ ANP 8.19672
150 5DEX 5E0 8.19672
151 5MDH NAD 8.19672
152 4MRT COA 8.19672
153 2YY7 NAD 8.19672
154 4JWX 1N4 8.19672
155 4MDH NAD 8.19672
156 1WMA AB3 9.01639
157 1WMA NDP 9.01639
158 4AP3 NAP 9.01639
159 4AP3 FAD 9.01639
160 1YKF NAP 9.01639
161 5GM9 CBK 9.01639
162 5J5Z FAD 9.01639
163 2F5Z FAD 9.01639
164 2PI8 NAG NAG NAG NAG NAG NAG 9.01639
165 4PLG NAI 9.01639
166 4PLG OXM 9.01639
167 2A92 NAI 9.01639
168 1Q9I TEO 9.01639
169 1Q9I FAD 9.01639
170 1MDZ PLP 9.01639
171 1MDZ DCS 9.01639
172 1LDN NAD 9.01639
173 4POO SAM 9.01639
174 1LYX PGA 9.83607
175 5AB7 MLC 9.83607
176 1U6R ADP 9.83607
177 2UYT ADP 9.83607
178 2UYT LRH 9.83607
179 3UCL CYH 9.83607
180 3UCL FAD 9.83607
181 3UCL NAP 9.83607
182 5JWC FAD 9.83607
183 2Q6B HR2 9.83607
184 5F52 ASP 9.83607
185 4K81 GTP 9.83607
186 3AB1 FAD 9.83607
187 9LDT NAD 9.83607
188 2YVJ FAD 10.0917
189 1MVQ MMA 10.6557
190 6CEP NAD 10.6557
191 6CEP OXM 10.6557
192 1VRP ADP 10.6557
193 1D4D FAD 10.6557
194 3OEN GLU 10.6557
195 1O94 ADP 10.6557
196 3GF4 UPG 10.6557
197 4DQ2 BTX 10.6557
198 3B6R ADP 10.6557
199 3GF4 FAD 10.6557
200 6BVM GNP 11.3772
201 4Z24 FAD 11.4754
202 5FFF NAP 11.4754
203 2Z6J FMN 11.4754
204 6DIO NAD 11.4754
205 2Q4W FAD 11.4754
206 1PFK ADP 11.4754
207 2NXW TPP 11.4754
208 5GZ6 NDP 11.4754
209 5GZ6 7C3 11.4754
210 4TXI FAD 11.4754
211 1MHW BP4 CYS DAR TYR PEA 11.9048
212 1KEV NDP 12.2951
213 5WGR FAD 12.2951
214 5X8G S0N 12.2951
215 1EQ2 NAP 13.1148
216 1BW9 NAD 13.1148
217 2VQD AP2 13.1148
218 1EZ4 NAD 13.1148
219 5K0A FAD 13.1148
220 1E6E FAD 13.1148
221 1C1X NAD 13.1148
222 3EWP APR 13.1148
223 4HDO GNP 13.1148
224 3RNM FAD 13.7931
225 4C3Y FAD 13.9344
226 4PLT OXM 13.9344
227 4PLT NAI 13.9344
228 4BG4 ADP 13.9344
229 1GUA GNP 13.9344
230 4C3Y ANB 13.9344
231 5ERG SAM 13.9344
232 1ZC3 GNP 13.9344
233 3NRZ FAD 13.9344
234 1FIQ FAD 13.9344
235 1LTH NAD 13.9344
236 6FDF SAH 13.9344
237 1M15 ARG 14.7541
238 1M15 ADP 14.7541
239 5GLN XYS 14.7541
240 2Q7V FAD 14.7541
241 1TZJ A3B 14.7541
242 4JD3 PLM 14.7541
243 4JD3 COA 14.7541
244 3HDY FDA 15.5738
245 5NMX NAP 15.5738
246 3HDY FAD 15.5738
247 5NMX FAD 15.5738
248 5TS5 FAD 15.5738
249 5L3S GNP 15.5738
250 3AXB PRO 15.5738
251 1FL2 FAD 17.2131
252 1RP7 TZD 17.2131
253 3JQ3 ADP 17.2131
254 3AXK NDP 18.0328
255 2JK0 ASP 18.0328
256 2X6T NAP 18.8525
257 5V6F MAN BMA MAN 19.6721
258 4YRY FAD 19.6721
259 3ZEI AWH 19.6721
260 5W3K NDP 19.6721
261 5W3K 9TY 19.6721
262 2FMD MAN MAN 20.4918
263 1ELI PYC 21.3115
264 6GAS FAD 21.3115
265 3QDW A2G 21.3115
266 3QDV A2G 21.3115
267 3ENG CBI 22.1311
268 1XXR MAN 23.7705
269 1VBO MAN 24.5902
270 1VBO MAN MAN MAN 24.5902
271 1JOT GAL A2G 24.5902
272 1C3M MAN MAN 34.4262
273 1WS5 MMA 37.7049
274 1WS4 AMG 37.7049
275 1KUJ MMA 37.7049
276 1WS4 GYP 37.7049
277 1UGY GLA BGC 37.7049
278 1UGY GLA GLC 37.7049
279 1UGW GAL 37.7049
280 1M26 GAL A2G 37.7049
281 1JAC AMG 37.7049
282 1UGX GAL MGC 37.7049
283 5Z75 NAD 37.7049
284 1TOQ AMG 40.1639
285 6FLZ MMA 45.082
286 2BMZ XLM 48.3607
Pocket No.: 2; Query (leader) PDB : 2GUC; Ligand: MAN; Similar sites found with APoc: 194
This union binding pocket(no: 2) in the query (biounit: 2guc.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 2HMT NAI None
2 1Q0H FOM None
3 1Q0H NDP None
4 5Z2L NDP None
5 5YSS NAD None
6 3CH6 311 1.63934
7 3CH6 NAP 1.63934
8 5C5H 4YB 1.63934
9 4I2D APC 1.63934
10 1UUO ORO 1.63934
11 1UUO BRF 1.63934
12 1UUO FMN 1.63934
13 3GD4 NAD 2.45902
14 2I7C AAT 3.27869
15 1O8B ABF 3.27869
16 2YBQ SAH 3.27869
17 3LL5 IPE 3.27869
18 3RG9 NDP 3.27869
19 5MQ5 ASP 4.09836
20 2DKH FAD 4.09836
21 1XKQ NDP 4.09836
22 1XDS SAM 4.09836
23 1TB3 FMN 4.09836
24 5TTJ FAD 4.09836
25 5I3B HQE 4.09836
26 1H82 FAD 4.09836
27 1H82 GZZ 4.09836
28 4K5S FAD 4.91803
29 4K5S PM0 4.91803
30 2JB2 PHE 4.91803
31 2JB2 FAD 4.91803
32 1COY AND 4.91803
33 1VL8 NAP 4.91803
34 3ICS ADP 4.91803
35 3LST SAH 4.91803
36 2BNE U5P 4.91803
37 3B20 NAD 4.91803
38 5EEH P9P 4.91803
39 5EEH SAH 4.91803
40 3K56 IS3 4.91803
41 5U8U FAD 4.91803
42 4EMI NAD 4.91803
43 5E1M SAH 4.91803
44 2HQM FAD 5.7377
45 3STK PLM 5.7377
46 1XSE NDP 5.7377
47 4OOE NDP 5.7377
48 4OOE FOM 5.7377
49 5WQP NAP 5.7377
50 5TWB FAD 5.7377
51 1ZGA SAH 5.7377
52 2PWY SAH 5.7377
53 2YYY NAP 5.7377
54 5ZBC FAD 5.7377
55 2R14 FMN 5.7377
56 2R14 TXD 5.7377
57 5ICE SAH 5.7377
58 5ICE 2H4 5.7377
59 2VVL FAD 5.7377
60 5GSN MMZ 5.7377
61 5GSN FAD 5.7377
62 5GSN NAP 5.7377
63 4U36 TNR 5.7377
64 6F7L FAD 6.55738
65 1V59 FAD 6.55738
66 2R4J FAD 6.55738
67 2R4J 13P 6.55738
68 1FP1 SAH 6.55738
69 5K4G ASP 6.55738
70 4JP3 CIT 6.55738
71 3T7S SAM 6.55738
72 1M0S CIT 6.55738
73 6CI9 NAP 7.37705
74 3LAD FAD 7.37705
75 2JDR L20 7.37705
76 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 7.37705
77 3AI8 HNQ 7.37705
78 5I60 67W 7.37705
79 5JY6 NAD 7.37705
80 2B4R AES 7.37705
81 2D7I NGA 7.37705
82 5J60 FAD 7.37705
83 5EOW FAD 7.37705
84 5MST FUM 8.19672
85 4E70 N7I 8.19672
86 2VBU CDP 8.19672
87 5MSD BEZ 8.19672
88 1BZL GCG 8.19672
89 2WA2 SAM 8.19672
90 2P53 NNG 8.19672
91 5BRT FAD 8.19672
92 3UZO GLU 8.19672
93 2ABJ CBC 8.19672
94 4IV9 FAD 9.01639
95 2XYQ SAH 9.01639
96 3OID NDP 9.01639
97 5KOX FAD 9.01639
98 5KOX RFP 9.01639
99 5T2U NAP 9.01639
100 2Y6Q FAD 9.01639
101 2Y6Q I7T 9.01639
102 1KAO GDP 9.58084
103 5THQ NDP 9.83607
104 3Q9T FAY 9.83607
105 1FFU FAD 9.83607
106 2AOT SAH 9.83607
107 3GMB FAD 9.83607
108 1JQD HSM 9.83607
109 4A6D SAM 9.83607
110 5YRV 5AD 9.83607
111 2WLT ASP 9.83607
112 4CQM NAP 9.83607
113 1LSS NAD 9.83607
114 1M2W NAD 9.83607
115 6N35 MAN MAN 9.83607
116 1JQD SAH 9.83607
117 1QZZ SAM 10.6557
118 2ZUX RAM 10.6557
119 4KRG SAH 10.6557
120 3HRD FAD 10.6557
121 1LFD GNP 10.7784
122 6FA4 GNP 10.9827
123 6D5H GNP 11.3772
124 6BVL GNP 11.3772
125 6D59 GNP 11.3772
126 6BVJ GNP 11.3772
127 6BVI GNP 11.3772
128 6D5E GNP 11.3772
129 6BVK GNP 11.3772
130 6D56 GNP 11.3772
131 6D5J GNP 11.3772
132 6D5L GNP 11.3772
133 6D5G GNP 11.3772
134 6D5M GNP 11.3772
135 6D55 GNP 11.3772
136 3P9C SAH 11.4754
137 5BSR AMP 11.4754
138 5BSR COA 11.4754
139 4DSG FAD 11.4754
140 4DSG UDP 11.4754
141 2IVD FAD 11.4754
142 2FLI DX5 11.4754
143 2B4Q NAP 11.4754
144 5FFF 5XC 11.4754
145 4L8V NAP 11.4754
146 3KB6 NAD 11.4754
147 1REO FAD 12.2951
148 5FOI MY8 12.2951
149 1MO9 FAD 12.2951
150 2HIM ASN 12.2951
151 2UZ1 TPP 12.2951
152 1MO9 KPC 12.2951
153 2HIM ASP 12.2951
154 2RAB NAD 12.2951
155 2RAB FAD 12.2951
156 2ABS ACP 12.2951
157 1LVL FAD 13.1148
158 5X68 FAD 13.1148
159 1XHL NDP 13.1148
160 2GAG NAD 13.1148
161 4OM8 NAD 13.1148
162 1KYZ SAH 13.1148
163 3QMN COA 13.1148
164 2CDU ADP 13.1148
165 1WA5 GTP 13.1148
166 5DNC ASN 13.9344
167 1DQX BMP 13.9344
168 5WPJ NDP 13.9344
169 1I9G SAM 13.9344
170 4R8L ASP 13.9344
171 1N62 FAD 14.7541
172 2RCU BUJ 14.7541
173 2IID FAD 14.7541
174 2IID PHE 14.7541
175 3MB5 SAM 14.7541
176 1FP2 SAH 16.3934
177 1FP2 HMO 16.3934
178 4XB2 HSE 16.3934
179 4XB2 NDP 16.3934
180 4ZOH FAD 17.2131
181 3SSO SAH 18.0328
182 1IYE PGU 18.0328
183 4BV6 FAD 18.8525
184 1FNZ A2G 19.6721
185 3CTY FAD 21.3115
186 5HSA FAS 23.7705
187 6CGD GNP 24.5902
188 6CGD AKN 24.5902
189 1KPG SAH 26.2295
190 3WQQ IB3 28.6885
191 3WQQ NDP 28.6885
192 4KP7 NAP 28.6885
193 4KP7 1UQ 28.6885
194 1BXK NAD 31.1475
Pocket No.: 3; Query (leader) PDB : 2GUC; Ligand: MAN; Similar sites found with APoc: 98
This union binding pocket(no: 3) in the query (biounit: 2guc.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 3O61 GDD None
2 5ZBL AMP None
3 4B5P ACO None
4 3BGD SAH None
5 3BGD PM6 None
6 3S2Y FMN None
7 2HNK SAH 0.83682
8 4YMH SAH 1.63934
9 2BEK ATP 1.63934
10 1O0S NAI 1.63934
11 2O4C NAD 2.45902
12 2ZC0 PMP 2.45902
13 3RFV 15L 2.45902
14 1ZK7 FAD 3.27869
15 4JWF SAH 3.27869
16 1PN0 FAD 3.27869
17 1PN0 IPH 3.27869
18 4JWH SAH 3.27869
19 4MIG G3F 3.27869
20 5I39 FAD 3.27869
21 1Q1R FAD 3.27869
22 2PT9 S4M 3.27869
23 2PT9 2MH 3.27869
24 4YKG NAD 4.09836
25 4YKG FAD 4.09836
26 2A8X FAD 4.09836
27 1XHC FAD 4.09836
28 3ITJ FAD 4.09836
29 2DKH 3HB 4.09836
30 3GDN HBX 4.91803
31 3L4S 3PG 4.91803
32 3L4S NAD 4.91803
33 5YJF 8WO 4.91803
34 5E1M PRO PRO LYS ARG ILE ALA 4.91803
35 1UXG FUM 5.7377
36 1UXG NAD 5.7377
37 2O3Z AI7 5.7377
38 3AB4 THR 5.7377
39 5YJI 8WO 5.7377
40 5YJI SAH 5.7377
41 3TO7 COA 5.7377
42 6F97 FAD 5.7377
43 1GV0 NAD 6.55738
44 5LD5 NAD 6.55738
45 3AAQ ARU 6.55738
46 4O0L NDP 6.55738
47 2GOU FMN 7.37705
48 2VD9 IN5 7.37705
49 2VD9 EPC 7.37705
50 4IXW IXW 7.37705
51 3LU1 NAD 7.37705
52 4JDR FAD 7.37705
53 1X7D ORN 7.37705
54 1X7D NAD 7.37705
55 6C4M NAP 8.19672
56 5SWB NAG BMA MAN MAN MAN MAN 8.19672
57 4M52 M52 8.19672
58 4M52 FAD 8.19672
59 2IVN ANP 9.01639
60 5TUK FAD 9.01639
61 2DFV NAD 9.83607
62 5X20 NAD 9.83607
63 2YVJ NAI 10.0917
64 1B8U NAD 10.3343
65 1B8U OAA 10.3343
66 1ZK4 AC0 10.6557
67 5ZAI COA 10.6557
68 5J7X FAD 10.6557
69 3GDH MGP 10.6557
70 1NAA 6FA 11.4754
71 4Z0H NAD 11.4754
72 1OYB HBA 11.4754
73 1OYB FMN 11.4754
74 5LOG SAH 12.2951
75 3GFB NAD 12.2951
76 2Q1W NAD 12.2951
77 1H9A NAP 12.2951
78 3DUW SAH 12.2951
79 3CB2 GDP 13.1148
80 2B9W FAD 13.1148
81 1BW9 PPY 13.1148
82 1TUF AZ1 13.9344
83 3JQ8 NAP 13.9344
84 4CM9 NAP 13.9344
85 1U7T NAD 13.9344
86 2VZ0 D64 13.9344
87 2VZ0 NAP 13.9344
88 3WGT QSC 14.7541
89 3WGT FAD 14.7541
90 1P4A PCP 14.7541
91 4MOP 2H5 15.5738
92 2QA1 FAD 16.3934
93 3O26 NDP 17.2131
94 1KGQ SCO 17.2131
95 1KGQ NPI 17.2131
96 3PT9 SAH 19.6721
97 4UP3 FAD 27.0492
98 1RM0 D6P 27.0492
Pocket No.: 4; Query (leader) PDB : 2GUC; Ligand: MAN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2guc.bio1) has 3 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 2GUC; Ligand: MAN; Similar sites found with APoc: 74
This union binding pocket(no: 5) in the query (biounit: 2guc.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 4RFM 3P6 None
2 4O4K 2PK None
3 3P8N L4T 1.63934
4 2BKA NDP 1.63934
5 4X6I 3Y1 4.09836
6 6FFI D8B 4.09836
7 5YU3 PRO 4.09836
8 5YU3 NAD 4.09836
9 1SB8 UD2 4.91803
10 1SB8 NAD 4.91803
11 4B74 1LH 4.91803
12 4FL3 ANP 4.91803
13 3EYA TDP 4.91803
14 2AE2 NAP 5.7377
15 6C2Z P1T 5.7377
16 5MZI FAD 5.7377
17 5MZI FYK 5.7377
18 2C80 GTX 5.7377
19 3KO8 NAD 5.7377
20 1V59 NAD 6.55738
21 2E5V FAD 6.55738
22 3S5W FAD 6.55738
23 5NUE NAD 6.55738
24 1WPQ NAD 6.55738
25 1TV5 FMN 6.55738
26 6GNC FAD 7.37705
27 1O2D NAP 7.37705
28 1D6S MET PLP 7.37705
29 1VHD NAP 7.37705
30 1RRM APR 7.37705
31 1S7G NAD 7.37705
32 5BRT CH9 8.19672
33 1F76 FMN 8.19672
34 1D7O TCL 8.19672
35 1D7O NAD 8.19672
36 4EXS X8Z 8.19672
37 1TDF FAD 9.01639
38 1TDF NAP 9.01639
39 1EFV FAD 9.01639
40 1EFV AMP 9.01639
41 4PU6 ASP 9.01639
42 3KJS NAP 9.01639
43 6AYU F6P 9.01639
44 2NU8 COA 9.01639
45 1QL9 ZEN 9.01639
46 1GQ2 NAP 9.01639
47 3D2M COA 9.01639
48 1T26 NAI 9.83607
49 1T26 GBD 9.83607
50 1XI9 PLP 9.83607
51 5OCM NAP 9.83607
52 3PFD FDA 9.83607
53 1ZK4 NAP 10.6557
54 1G55 SAH 10.6557
55 1PS9 FAD 11.4754
56 4IPE ANP 11.4754
57 5XWV 8H6 12.2951
58 5XWV NDP 12.2951
59 2AQJ TRP 12.2951
60 2AQJ FAD 12.2951
61 5G5G FAD 12.2951
62 3OND ADN 13.1148
63 3OND NAD 13.1148
64 2GAG FOA 13.1148
65 1KGZ PRP 13.1148
66 5K6A NAP 13.9344
67 3JQF NAP 13.9344
68 1Z45 NAD 14.7541
69 1E3I CXF 15.5738
70 5MIT FAD 15.5738
71 5MIT NAP 15.5738
72 4L1F FAD 23.7705
73 4J56 FAD 24.5902
74 1KPH SAH 27.0492
Pocket No.: 6; Query (leader) PDB : 2GUC; Ligand: MAN; Similar sites found with APoc: 74
This union binding pocket(no: 6) in the query (biounit: 2guc.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 3CMC NAD None
2 5AHS FAD 3.27869
3 1YKJ FAD 4.09836
4 2I0K FAD 4.09836
5 2RGJ FAD 4.09836
6 1T5B FMN 4.09836
7 4U8P UDP 4.09836
8 4U8P FDA 4.09836
9 3V1Y NAD 4.09836
10 3NYC FAD 4.09836
11 3NYC IAR 4.09836
12 4GN8 ASO 4.91803
13 4HA6 FAD 4.91803
14 1M7Y PPG 4.91803
15 2D2I NAP 4.91803
16 4J7U NAP 4.91803
17 4J7U YTZ 4.91803
18 1VKO NAD 4.91803
19 2B1N LYS ALA SER VAL GLY 4.91803
20 3B1J NAD 4.91803
21 5YJF SAH 4.91803
22 1Z6Z NAP 4.91803
23 4HA9 NDP 5.7377
24 2F5T MAL 5.7377
25 1OAA OAA 5.7377
26 1PHP ADP 5.7377
27 4EI7 GDP 5.7377
28 2D3N GLC GLC GLC 5.7377
29 6EL3 NAP 5.7377
30 4C5N ACP 5.7377
31 5Y77 FAD 5.7377
32 1RPN NDP 6.26866
33 5JE8 NAD 6.55738
34 4CJX NAP 6.55738
35 6F3M NAD 6.55738
36 4A59 AMP 6.55738
37 2ZJ1 ARJ 7.37705
38 2ZJ1 NAD 7.37705
39 2B4R NAD 7.37705
40 1E3W NAD 7.37705
41 5ZZ6 ADP 8.19672
42 2VYN NAD 8.19672
43 3C3Y SAH 8.19672
44 3H9E NAD 8.19672
45 6AA8 NAD 9.01639
46 3OVR 5SP 9.01639
47 1NLU IVA PHI TYB 9.01639
48 1YQZ FAD 9.83607
49 1VGR COA 9.83607
50 1QX4 FAD 10.6557
51 3CIF G3H 10.6557
52 3CIF NAD 10.6557
53 5OE4 3UK 10.6557
54 4USR FAD 11.4754
55 1NAA ABL 11.4754
56 1EP2 ORO 11.4754
57 1EP2 FMN 11.4754
58 3LZW FAD 12.2951
59 1C7R PA5 12.2951
60 5UR0 NAD 12.2951
61 1KYZ FER 13.1148
62 1DSS NAD 13.1148
63 1KOJ PAN 13.1148
64 2GAG FAD 13.1148
65 5FJN BE2 13.9344
66 5FJN FAD 13.9344
67 2Q3O FMN 14.7541
68 5GLN XYP XYP XYP 14.7541
69 6H3O FAD 15.5738
70 5OC1 FAD 17.2131
71 2WET FAD 19.6721
72 4MSG 2C6 21.3115
73 1PJS NAD 21.3115
74 1RM0 NAI 27.0492
Pocket No.: 7; Query (leader) PDB : 2GUC; Ligand: MAN; Similar sites found with APoc: 20
This union binding pocket(no: 7) in the query (biounit: 2guc.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 2B4D COA None
2 3UOY NAP 3.27869
3 3UOY FAD 3.27869
4 2QV7 ADP 3.27869
5 1VFS DCS 4.09836
6 2DT9 THR 4.09836
7 1Z82 NDP 4.09836
8 4KWI NAP 4.91803
9 4KWI 1TJ 4.91803
10 2ZPA ACO 4.91803
11 2C5A NAD 7.37705
12 2C5A GDC 7.37705
13 3CQD ATP 8.19672
14 6BQ6 TER 8.19672
15 1DZK PRZ 9.01639
16 1NVM NAD 9.83607
17 5NII FAD 10.6557
18 3I54 CMP 11.4754
19 3NRR NAP 13.1148
20 3NRR D16 13.1148
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